FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jack Harkema

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Disorders

Procedures

Administration, Inhalation

Co-author Network

Publications

TOP 3
Alessandra Livraghi-Butrico; Wanda O Neal; Scott H Randell; Troy D Rogers; Kristen J Wilkinson; Richard C Boucher; Rodney C Gilmore; Jack R Harkema; Elizabeth J Kelly; Barbara R Grubb
Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.
Stephan A Carey; Dallas M Hyde; Zahidul Islam; James J Pestka; Charles G Plopper; Jack R Harkema
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys.
Krista K Greenwood; Jack R Harkema; Daven N Jackson-Humbles; Steven P Proper; Yogesh Saini; James G Wagner; Lori A Bramble; John J LaPres
Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jack Harkema (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Alessandra Livraghi-Butrico; Wanda O Neal; Scott H Randell; Troy D Rogers; Kristen J Wilkinson; Richard C Boucher; Rodney C Gilmore; Jack R Harkema; Elizabeth J Kelly; Barbara R Grubb
Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.
American journal of physiology. Lung cellular and molecular physiology 2013;304(7):L469-80.
2012: Stephan A Carey; Dallas M Hyde; Zahidul Islam; James J Pestka; Charles G Plopper; Jack R Harkema
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys.
Toxicologic pathology 2012;40(6):887-98.
2012: Krista K Greenwood; Jack R Harkema; Daven N Jackson-Humbles; Steven P Proper; Yogesh Saini; James G Wagner; Lori A Bramble; John J LaPres
Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.
American journal of physiology. Lung cellular and molecular physiology 2012;302(5):L455-62.
2012: James G Wagner; Gerald J Keeler; Masako Morishita; Jack R Harkema
Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies.
Environmental health : a global access science source 2012;11():45.
2011: Michelle M Angrish; Jack R Harkema; A D Jones; Timothy R Zacharewski
Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.
Toxicological sciences : an official journal of the Society of Toxicology 2011;124(2):299-310.
2011: Peer W F Karmaus; Barbara L F Kaplan; Weimin Chen; Robert B Crawford; Jack R Harkema; Norbert E Kaminski
Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection.
Journal of leukocyte biology 2011;90(5):983-95.
2011: Anna K Kopec; Bryan D Mets; Dave Potter; Sarah E Reese; Bonnie Sharratt; Colleen Tashiro; Kellie J Archer; Lyle Burgoon; Michelle L D'Souza; Jack R Harkema; Timothy R Zacharewski
Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.
Toxicology and applied pharmacology 2011;256(2):154-67.
2011: Ali S Kamal; Annette C Rohr; Bhramar Mukherjee; Masako Morishita; Gerald J Keeler; Jack R Harkema; James G Wagner
PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio.
Inhalation toxicology 2011;23(7):417-30.
2011: Annette C Rohr; Ali Kamal; Masako Morishita; Bhramar Mukherjee; Gerald J Keeler; Jack R Harkema; James G Wagner
Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan.
Environmental health perspectives 2011;119(4):474-80.
2011: Kinjal Maniar-Hew; Edward M Postlethwait; Michelle V Fanucchi; Carol A Ballinger; Michael J Evans; Jack R Harkema; Stephan A Carey; Ruth J Mcdonald; Alfred A Bartolucci; Lisa A Miller
Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge.
American journal of physiology. Lung cellular and molecular physiology 2011;300(3):L462-71.
2011: Stephan A Carey; Carol A Ballinger; Charles G Plopper; Ruth J Mcdonald; Alfred A Bartolucci; Edward M Postlethwait; Jack R Harkema
Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys.
American journal of physiology. Lung cellular and molecular physiology 2011;300(2):L242-54.
2011: Zhaobin Xu; Yifeng Yang; Mianhua Zhong; James G Wagner; Aixia Wang; Xiaohua Xu; Lori A Bramble; Lung Chi Chen; Jack R Harkema; Ian P Hotchkiss; Ryan P Lewandowski; Morton Lippmann; Sanjay Rajagopalan; Qinghua Sun
Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues.
Particle and fibre toxicology 2011;8():20.
2010: Marylène Fortin; James G Wagner; Julie Brault; Jack R Harkema; Paolo M Renzi; Luc Paquet; Nicolay Ferrari
Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.
Cytokine 2010;52(3):194-202.
2010: Anna K Kopec; Lyle Burgoon; Daher Ibrahim-Aibo; Ashley R Burg; Andrea W Lee; Colleen Tashiro; Dave Potter; Bonnie Sharratt; Jack R Harkema; Craig Rowlands; Robert A Budinsky; Timothy R Zacharewski
Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(1):286-97.
2010: Ning Li; Jack R Harkema; Ryan P Lewandowski; Meiying Wang; Lori A Bramble; Glenn R Gookin; Zhi Ning; Michael T Kleinman; Constantinos Sioutas; Andre E Nel
Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares.
American journal of physiology. Lung cellular and molecular physiology 2010;299(3):L374-83.
2010: Yogesh Saini; Krista K Greenwood; Christian Merrill; Kyung Y Kim; Sonika Patial; Narayanan Parameswaran; Jack R Harkema; John J LaPres
Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.
Toxicological sciences : an official journal of the Society of Toxicology 2010;116(2):673-81.
2010: Annette C Rohr; James G Wagner; Masako Morishita; Ali Kamal; Gerald J Keeler; Jack R Harkema
Cardiopulmonary responses in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from Detroit, Michigan.
Inhalation toxicology 2010;22(6):522-33.
2010: Daher Ibrahim Aibo; Neil P Birmingham; Ryan Lewandowski; Jane F Maddox; Robert A Roth; Patricia E Ganey; James G Wagner; Jack R Harkema
Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):267-85.
2010: Kara N Corps; Zahidul Islam; James J Pestka; Jack R Harkema
Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury.
Toxicologic pathology 2010;38(3):429-51.
2010: Barbara L F Kaplan; Jody E Lawver; Peer W F Karmaus; Thitirat Ngaotepprutaram; Neil P Birmingham; Jack R Harkema; Norbert E Kaminski
The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin.
Toxicologic pathology 2010;38(3):382-92.
2010: Anna K Kopec; Lyle Burgoon; Daher Ibrahim-Aibo; Bryan D Mets; Colleen Tashiro; Dave Potter; Bonnie Sharratt; Jack R Harkema; Timothy R Zacharewski
PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands.
Toxicology and applied pharmacology 2010;243(3):359-71.
2010: Xuedong Kang; Ning Li; Meiying Wang; Pinmanee Boontheung; Constantinos Sioutas; Jack R Harkema; Lori A Bramble; Andre E Nel; Joseph A Loo
Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid.
Proteomics 2010;10(3):520-31.
2010: Yogesh Saini; Kyung Y Kim; Ryan Lewandowski; Lori A Bramble; Jack R Harkema; John J LaPres
Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.
American journal of physiology. Lung cellular and molecular physiology 2010;298(2):L139-47.
2009: Jack R Harkema; James G Wagner; Norbert E Kaminski; Masako Morishita; Gerald J Keeler; Jacob D McDonald; Edward G Barrett
Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats.
Research report (Health Effects Institute) 2009;(145):5-55.
2009: Robert D Brook; Bruce Urch; J Timothy Dvonch; Robert L Bard; Mary Speck; Gerald J Keeler; Masako Morishita; Frank J Marsik; Ali S Kamal; Niko A Kaciroti; Jack R Harkema; Paul Corey; Frances Silverman; Diane R Gold; Greg Wellenius; Murray A Mittleman; Sanjay Rajagopalan; Jeffrey R Brook
Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans.
Hypertension 2009;54(3):659-67.
2009: Ning Li; Meiying Wang; Lori A Bramble; Debra A Schmitz; James J Schauer; Constantinos Sioutas; Jack R Harkema; Andre E Nel
The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.
Environmental health perspectives 2009;117(7):1116-23.
2009: Elizabeth M Vancza; Sheung P Ng; Jack R Harkema; Judith T Zelikoff
The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms.
Journal of immunotoxicology 2009;6(2):94-103.
2009: James G Wagner; Jack R Harkema; Qing Jiang; Beate Illek; Bruce N Ames; David Peden
Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats.
Toxicologic pathology 2009;37(4):481-91.
2009: Chengfeng Yang; Ying S Tan; Jack R Harkema; Sandra Z Haslam
Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains.
Reproductive toxicology (Elmsford, N.Y.) 2009;27(3-4):299-306.
2009: Brooke L Heidenfelder; David M Reif; Jack R Harkema; Elaine A Cohen Hubal; Edward E Hudgens; Lori A Bramble; James G Wagner; Masako Morishita; Gerald J Keeler; Stephen Wilton Edwards; Jane E Gallagher
Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):207-21.
2009: Zahidul Islam; Junko Shinozuka; Jack R Harkema; James J Pestka
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum.
Journal of toxicology and environmental health. Part A 2009;72(20):1242-51.
2008: James J Pestka; Iwona Yike; Dorr Dearborn; Marsha D W Ward; Jack R Harkema
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(1):4-26.
2008: Chidozie J Amuzie; Jack R Harkema; James J Pestka
Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure.
Toxicology 2008;248(1):39-44.
2008: Marcus A Mall; Jack R Harkema; Joanna B Trojanek; Diana Treis; Alessandra Livraghi; Susanne Schubert; Zhe Zhou; Silvia M Kreda; Stephen L Tilley; Elizabeth J Hudson; Wanda O Neal; Richard C Boucher
Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice.
American journal of respiratory and critical care medicine 2008;177(7):730-42.
2008: John P Buchweitz; Peer W F Karmaus; Kurt J Williams; Jack R Harkema; Norbert E Kaminski
Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of Delta9-tetrahydrocannabinol.
Journal of leukocyte biology 2008;83(3):785-96.
2008: Anna K Kopec; Darrell R Boverhof; Lyle Burgoon; Daher Ibrahim-Aibo; Jack R Harkema; Colleen Tashiro; Brock Chittim; Timothy R Zacharewski
Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;102(1):61-75.
2008: James G Wagner; Qing Jiang; Jack R Harkema; B N Ames; Beate Illek; Robert A S Roubey; David Peden
Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(3):501-11.
2007: Tobias E Rodriguez; Nicole R Falkowski; Jack R Harkema; Gary B Huffnagle
Role of neutrophils in preventing and resolving acute fungal sinusitis.
Infection and immunity 2007;75(12):5663-8.
2007: John P Buchweitz; Peer W F Karmaus; Jack R Harkema; Kurt J Williams; Norbert E Kaminski
Modulation of airway responses to influenza A/PR/8/34 by Delta9-tetrahydrocannabinol in C57BL/6 mice.
The Journal of pharmacology and experimental therapeutics 2007;323(2):675-83.
2007: James G Wagner; Qing Jiang; Jack R Harkema; Beate Illek; Dhavalkumar D Patel; Bruce N Ames; David Peden
Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol.
Free radical biology & medicine 2007;43(8):1176-88.
2007: Zahidul Islam; Chidozie J Amuzie; Jack R Harkema; James J Pestka
Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):526-41.
2007: Barry Rockx; Timothy Sheahan; Eric Donaldson; Jack R Harkema; Amy C Sims; Mark T Heise; Raymond J Pickles; Mark Cameron; David Kelvin; Ralph S Baric
Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice.
Journal of virology 2007;81(14):7410-23.
2007: Lynn H Pottenger; Linda A Malley; Matthew S Bogdanffy; E Maria Donner; Patricia B Upton; Yutai Li; Vernon E Walker; Jack R Harkema; Marcy I Banton; James A Swenberg
Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):336-47.
2007: James G Wagner; Jack R Harkema
Rodent models of allergic rhinitis: relevance to human pathophysiology.
Current allergy and asthma reports 2007;7(2):134-40.
2007: John P Buchweitz; Jack R Harkema; Norbert E Kaminski
Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice.
Toxicologic pathology 2007;35(3):424-35.
2007: Maoxiang Li; Jack R Harkema; Christopher F Cuff; James J Pestka
Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(2):412-26.
2007: Neil P Birmingham; Sitaram Parvataneni; Hanem M Ahmed Hassan; Jack R Harkema; Sridhar Samineni; Lalitha Navuluri; Caleb James Kelly; Venu Gangur
An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut.
International archives of allergy and immunology 2007;144(3):203-10.
2007: Stephan A Carey; Kevin R Minard; Lynn L Trease; James G Wagner; Guilherme J M Garcia; Carol A Ballinger; Julia Kimbell; Charles G Plopper; Richard A Corley; Edward M Postlethwait; Jack R Harkema; Daniel R Einstein
Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques.
Toxicologic pathology 2007;35(1):27-40.
2007: Gerald J Keeler; Masako Morishita; James G Wagner; Jack R Harkema
Characterization of urban atmospheres during inhalation exposure studies in Detroit and Grand Rapids, Michigan.
Toxicologic pathology 2007;35(1):15-22.
2006: Damon Deming; Timothy Sheahan; Mark T Heise; Boyd Yount; Nancy L Davis; Amy C Sims; Mehul Suthar; Jack R Harkema; Alan C Whitmore; Raymond J Pickles; Ande West; Eric Donaldson; Kris Curtis; Robert Johnston; Ralph S Baric
Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.
PLoS medicine 2006;3(12):e525.
2006: Darrell R Boverhof; Lyle Burgoon; Colleen Tashiro; Bonnie Sharratt; Brock Chittim; Jack R Harkema; Donna L Mendrick; Timothy R Zacharewski
Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):398-416.
2006: Maoxiang Li; Jack R Harkema; Zahidul Islam; Christopher F Cuff; James J Pestka
T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis.
Toxicology and applied pharmacology 2006;217(1):76-85.
2006: Joel Lugo; Jack R Harkema; Heather deFeijter-Rupp; Lisa R Bartner; Daniel Boruta; N Edward Robinson
Airway inflammation is associated with mucous cell metaplasia and increased intraepithelial stored mucosubstances in horses.
Veterinary journal (London, England : 1997) 2006;172(2):293-301.
2006: Zahidul Islam; Jack R Harkema; James J Pestka
Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain.
Environmental health perspectives 2006;114(7):1099-107.
2006: Aimen K Farraj; Jack R Harkema; Norbert E Kaminski
Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(1):321-8.
2006: Madhu P Sirivelu; Sheba M J MohanKumar; James G Wagner; Jack R Harkema; Puliyur S Mohankumar
Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease.
Environmental health perspectives 2006;114(6):870-4.
2006: Dallas M Hyde; Jack R Harkema; Nancy K Tyler; Charles G Plopper
Design-based sampling and quantitation of the respiratory airways.
Toxicologic pathology 2006;34(3):286-95.
2006: Jack R Harkema; Stephan A Carey; James G Wagner
The nose revisited: a brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium.
Toxicologic pathology 2006;34(3):252-69.
2005: Joshua C Kwekel; Lyle Burgoon; Jeremy W Burt; Jack R Harkema; Timothy R Zacharewski
A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling.
Physiological genomics 2005;23(3):327-42.
2005: Michaela Aufderheide; Daniel L Costa; Robert Devlin; Victor Feron; Jack R Harkema; Yuzo Hayashi; Jürgen Pauluhn; Horst Spielmann
Experimental Assessment of the Toxicological Effects of Inhaled Complex Mixtures on the Respiratory System, 23-25 April 2005, Barcelona, Spain. Summary and conclusions of the review committee.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2005;57 Suppl 1():239-43.
2005: Jack R Harkema; James G Wagner
Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: enhancement of toxicant-induced airway injury.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2005;57 Suppl 1():129-41.
2005: Darrell R Boverhof; Lyle Burgoon; Colleen Tashiro; Brock Chittim; Jack R Harkema; Donald B Jump; Timothy R Zacharewski
Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(2):1048-63.
2005: J Foster Harris; Mark J Fischer; Jon R Hotchkiss; Brett P Monia; Scott H Randell; Jack R Harkema; Stephanie Holmgren
Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium.
American journal of respiratory and critical care medicine 2005;171(7):764-72.
2004: Erin Gensch; Marianne Gallup; Anatol Sucher; Daizong Li; Assefa Gebremichael; Hassan Lemjabbar; Aklilu Mengistab; Vijay Dasari; Jon A Hotchkiss; Jack R Harkema; Carol Basbaum
Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.
The Journal of biological chemistry 2004;279(37):39085-93.
2004: Masako Morishita; Gerald J Keeler; James Wagner; Frank J Marsik; Edward Timm; J Timothy Dvonch; Jack R Harkema
Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit.
Inhalation toxicology 2004;16(10):663-74.
2004: Jack R Harkema; Gerald J Keeler; James Wagner; Masako Morishita; Edward Timm; Jon A Hotchkiss; Frank J Marsik; Timothy Dvonch; Norbert E Kaminski; Edward Barr
Effects of concentrated ambient particles on normal and hypersecretory airways in rats.
Research report (Health Effects Institute) 2004;(120):1-68; discussion 69-79.
2004: J Timothy Dvonch; Robert D Brook; Gerald J Keeler; Sanjay Rajagopalan; Louis G D'Alecy; Frank J Marsik; Masako Morishita; Fuyuen Y Yip; Jeffrey R Brook; Edward Timm; James G Wagner; Jack R Harkema
Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine.
Inhalation toxicology 2004;16(6-7):473-80.
2004: Aimen K Farraj; Jack R Harkema; Norbert E Kaminski
Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):315-25.
2004: Marcus Mall; Barbara R Grubb; Jack R Harkema; Wanda O Neal; Richard C Boucher
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.
Nature medicine 2004;10(5):487-93.
2004: Stephanie Holmgren; J Foster Harris; Jon A Hotchkiss; Jack R Harkema
DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS.
American journal of physiology. Lung cellular and molecular physiology 2004;286(2):L268-74.
2003: James G Wagner; Steven J Van Dyken; Janelle R Wierenga; Jon A Hotchkiss; Jack R Harkema
Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):437-46.
2003: Steven Yee; Jack R Harkema; Patricia E Ganey; Robert A Roth
The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):457-69.
2003: Aimen K Farraj; Jack R Harkema; Tong-Rong Jan; Norbert E Kaminski
Immune responses in the lung and local lymph node of A/J mice to intranasal sensitization and challenge with adjuvant-free ovalbumin.
Toxicologic pathology 2003;31(4):432-47.
2003: Stephen H Gavett; Najwa Haykal-Coates; Jerry W Highfill; Allen D Ledbetter; Lung Chi Chen; Mitchell D Cohen; Jack R Harkema; James G Wagner; Daniel L Costa
World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice.
Environmental health perspectives 2003;111(7):981-91.
2003: Tong-Rong Jan; Aimen K Farraj; Jack R Harkema; Norbert E Kaminski
Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice.
Toxicology and applied pharmacology 2003;188(1):24-35.
2002: Joel Lugo; John A Stick; John F Peroni; Jack R Harkema; Frederik J Derksen; N Edward Robinson
Safety and efficacy of a technique for thoracoscopically guided pulmonary wedge resection in horses.
American journal of veterinary research 2002;63(9):1232-40.
2002: James G Wagner; Jon A Hotchkiss; Jack R Harkema
Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):284-94.
2002: James G Wagner; Jack R Harkema; Robert A Roth
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat.
Shock (Augusta, Ga.) 2002;17(2):151-8.
2002: Jack R Harkema; James G Wagner
Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways.
Novartis Foundation symposium 2002;248():181-97; discussion 197-200, 277-82.
2001: Andrew M Jefcoat; J A Hotchkiss; Vinzenz Gerber; Jack R Harkema; Carol Basbaum; N Edward Robinson
Persistent mucin glycoprotein alterations in equine recurrent airway obstruction.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L704-12.
2001: James G Wagner; Jon A Hotchkiss; Jack R Harkema
Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations.
Environmental health perspectives 2001;109 Suppl 4():591-8.
2001: C S Young; J M Palma; B D Mosher; Jack R Harkema; D F Naylor; Richard E Dean; Elahe Crockett
Hepatic ischemia/reperfusion injury in P-selectin and intercellular adhesion molecule-1 double-mutant mice.
The American surgeon 2001;67(8):737-44.
2001: B Mosher; R Dean; Jack R Harkema; D Remick; J Palma; Elahe Crockett
Inhibition of Kupffer cells reduced CXC chemokine production and liver injury.
The Journal of surgical research 2001;99(2):201-10.
2001: James G Wagner; Steven J Van Dyken; Jon A Hotchkiss; Jack R Harkema
Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(2):338-47.
2001: Fernando A Rivera-Chavez; Luis H Toledo-Pereyra; Gustavo Martinez-Mier; DT Nora; Jack R Harkema; Ben Bachulis; Richard E Dean
L-selectin blockade and liver function in rats after uncontrolled hemorrhagic shock.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2001;14(1):7-12.
2000: HY Cho; Jon A Hotchkiss; CB Bennett; Jack R Harkema
Neutrophil-dependent and neutrophil-independent alterations in the nasal epithelium of ozone-exposed rats.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):629-36.
2000: Steven Yee; Shawn Kinser; DA Hill; Charles C Barton; Jon A Hotchkiss; Jack R Harkema; Patricia E Ganey; Robert A Roth
Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline.
Toxicology and applied pharmacology 2000;166(3):173-85.
2000: Hui-Ren Zhou; Jack R Harkema; Jon A Hotchkiss; D Yan; Robert A Roth; James J Pestka
Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):253-63.
1999: HY Cho; Jon A Hotchkiss; Jack R Harkema
Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats.
Toxicological sciences : an official journal of the Society of Toxicology 1999;51(1):135-45.
1999: HY Cho; Jon A Hotchkiss; CB Bennett; Jack R Harkema
Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium.
Toxicology and applied pharmacology 1999;158(2):92-102.
1999: Michelle V Fanucchi; Jack R Harkema; Charles G Plopper; Jon A Hotchkiss
In vitro culture of microdissected rat nasal airway tissues.
American journal of respiratory cell and molecular biology 1999;20(6):1274-85.
1999: Hui-Ren Zhou; Jack R Harkema; D Yan; James J Pestka
Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol).
Journal of toxicology and environmental health. Part A 1999;57(2):115-36.
1999: K R Vesely; Edward S Schelegle; Mary Y Stovall; Jack R Harkema; JF Green; Dallas M Hyde
Breathing pattern response and epithelial labeling in ozone-induced airway injury in neutrophil-depleted rats.
American journal of respiratory cell and molecular biology 1999;20(4):699-709.
1999: K R Vesely; Dallas M Hyde; Mary Y Stovall; Jack R Harkema; JF Green; Edward S Schelegle
Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;86(3):951-62.
1999: Jack R Harkema; Jon A Hotchkiss; E B Barr; CB Bennett; Marianne Gallup; J K Lee; Carol Basbaum
Long-lasting effects of chronic ozone exposure on rat nasal epithelium.
American journal of respiratory cell and molecular biology 1999;20(3):517-29.
1999: M Longphre; L Zhang; Jack R Harkema; Steven R Kleeberger
Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;86(1):341-9.
1998: Michelle V Fanucchi; Jon A Hotchkiss; Jack R Harkema
Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium.
Toxicology and applied pharmacology 1998;152(1):1-9.
1998: Jon A Hotchkiss; R Hilaski; H Cho; K Regan; P Spencer; K Slack; Jack R Harkema
Fluticasone propionate attenuates ozone-induced rhinitis and mucous cell metaplasia in rat nasal airway epithelium.
American journal of respiratory cell and molecular biology 1998;18(1):91-9.
1997: Robert A Roth; Jack R Harkema; James J Pestka; Patricia E Ganey
Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
Toxicology and applied pharmacology 1997;147(2):300-11.
1997: Steven R Kleeberger; Roy Levitt; Liu-Yi Zhang; M Longphre; Jack R Harkema; Anne E Jedlicka; Scott M Eleff; D DiSilvestre; Kenneth J Holroyd
Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice.
Nature genetics 1997;17(4):475-8.
1997: Jack R Harkema; Jon A Hotchkiss; W C Griffith
Mucous cell metaplasia in rat nasal epithelium after a 20-month exposure to ozone: a morphometric study of epithelial differentiation.
American journal of respiratory cell and molecular biology 1997;16(5):521-30.
1997: Jack R Harkema; P J Catalano; Jon A Hotchkiss
Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XII: Atrophy of bone in nasal turbinates.
Research report (Health Effects Institute) 1997;(65 ( Pt 12)):1-19; discussion 21-6.
1997: Jon A Hotchkiss; Jack R Harkema; Neil Johnson
Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5 ppm ozone.
Toxicology and applied pharmacology 1997;143(1):75-82.
1997: AP Brown; Jack R Harkema; A E Schultze; Robert A Roth; Patricia E Ganey
Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration.
Shock (Augusta, Ga.) 1997;7(3):186-92.
1995: Jon A Hotchkiss; W A Evans; B T Chen; Gregory L Finch; Jack R Harkema
Regional differences in the effects of mainstream cigarette smoke on stored mucosubstances and DNA synthesis in F344 rat nasal respiratory epithelium.
Toxicology and applied pharmacology 1995;131(2):316-24.
1995: P J Catalano; L Y Chang; Jack R Harkema; D A Kaden; Jerold A Last; P W Mellick; W C Parks; Kent E Pinkerton; B Radhakrishnamurthy; L M Ryan
Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XI: Integrative Summary.
Research report (Health Effects Institute) 1995;(65 Pt 11):1-54; discussion 55-85.
1995: Rogene F Henderson; Kevin E Driscoll; Jack R Harkema; R C Lindenschmidt; I Y Chang; K R Maples; Edward B Barr
A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;24(2):183-97.
1994: Jack R Harkema; K T Morgan; E A Gross; P J Catalano; WC Griffith
Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part VII: Effects on the nasal mucociliary apparatus.
Research report (Health Effects Institute) 1994;(65 Pt 7):3-26; discussion 27-34.
1994: Jack R Harkema; Joe L Mauderly
Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part V: Effects on pulmonary function.
Research report (Health Effects Institute) 1994;(65 Pt 5):3-17; discussion 19-26.
1994: Jerold A Last; T R Gelzleichter; Jack R Harkema; Susan N Hawk
Consequences of prolonged inhalation of ozone on Fischer-344/N rats: collaborative studies. Part I: Content and cross-linking of lung collagen.
Research report (Health Effects Institute) 1994;(65):1-29; discussion 31-40.
1993: Jerold A Last; T Gelzleichter; Jack R Harkema; W C Parks; P Mellick
Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats.
Toxicology 1993;84(1-3):83-102.
1993: Jack R Harkema; Charles G Plopper; Dallas M Hyde; J A St George; Dennis W Wilson; D L Dungworth
Response of macaque bronchiolar epithelium to ambient concentrations of ozone.
The American journal of pathology 1993;143(3):857-66.
1993: Rogene F Henderson; Jon A Hotchkiss; I Y Chang; B R Scott; Jack R Harkema
Effect of cumulative exposure on nasal response to ozone.
Toxicology and applied pharmacology 1993;119(1):59-65.
1992: Jack R Harkema; Jon A Hotchkiss
In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways. Quantitative histochemistry.
The American journal of pathology 1992;141(2):307-17.
1992: D G Thomassen; Jack R Harkema; J D Sun; N D Stephens; WC Griffith
The role of ozone in tracheal cell transformation.
Research report (Health Effects Institute) 1992;(50):1-19; discussion 21-32.
1991: Kristen J Nikula; P J Sabourin; B C Frietag; A J Birdwhistell; Jon A Hotchkiss; Jack R Harkema
Biochemical and morphologic responses of rat nasal epithelia to hyperoxia.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1991;17(4):675-83.
1991: D G Thomassen; Jack R Harkema; N D Stephens; WC Griffith
Preneoplastic transformation of rat tracheal epithelial cells by ozone.
Toxicology and applied pharmacology 1991;109(1):137-48.
1991: Rogene F Henderson; Jack R Harkema; Jon A Hotchkiss; D S Boehme
Effect of blood leucocyte depletion on the inflammatory response of the lung to quartz.
Toxicology and applied pharmacology 1991;109(1):127-36.
1990: Jack R Harkema
Comparative pathology of the nasal mucosa in laboratory animals exposed to inhaled irritants.
Environmental health perspectives 1990;85():231-8.
1990: N F Johnson; Jon A Hotchkiss; Jack R Harkema; Rogene F Henderson
Proliferative responses of rat nasal epithelia to ozone.
Toxicology and applied pharmacology 1990;103(1):143-55.
1990: J A Bond; Jack R Harkema; Rogene F Henderson; Joe L Mauderly; R O McClellan; R K Wolff
The role of DNA adducts in diesel exhaust-induced pulmonary carcinogenesis.
Progress in clinical and biological research 1990;340C():259-69.
1989: Jon A Hotchkiss; Jack R Harkema; J D Sun; Rogene F Henderson
Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats.
Toxicology and applied pharmacology 1989;98(2):289-302.
1989: R K Wolff; J A Bond; J D Sun; Rogene F Henderson; Jack R Harkema; WC Griffith; Joe L Mauderly; R O McClellan
Effects of adsorption of benzo[a]pyrene onto carbon black particles on levels of DNA adducts in lungs of rats exposed by inhalation.
Toxicology and applied pharmacology 1989;97(2):289-99.
1989: Jack R Harkema; Jon A Hotchkiss; R F Henderson
Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: quantitative histochemistry.
Toxicologic pathology 1989;17(3):525-35.
1989: R K Wolff; WC Griffith; Rogene F Henderson; Fletcher F Hahn; Jack R Harkema; A H Rebar; A F Eidson; R O McClellan
Effects of repeated inhalation exposures to 1-nitropyrene, benzo[a]pyrene, Ga2O3 particles, and SO2 alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histopathology.
Journal of toxicology and environmental health 1989;27(1):123-38.
1989: Joe L Mauderly; William E Bechtold; J A Bond; A L Brooks; B T Chen; R G Cuddihy; Jack R Harkema; Rogene F Henderson; Neil Johnson; K Rithidech
Comparison of 3 methods of exposing rats to cigarette smoke.
Experimental pathology 1989;37(1-4):194-7.
1988: J A Bond; R K Wolff; Jack R Harkema; Joe L Mauderly; Rogene F Henderson; WC Griffith; R O McClellan
Distribution of DNA adducts in the respiratory tract of rats exposed to diesel exhaust.
Toxicology and applied pharmacology 1988;96(2):336-46.
1988: J D Sun; J A Pickrell; Jack R Harkema; S I McLaughlin; Fletcher Hahn; Rogene F Henderson
Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis.
Experimental and molecular pathology 1988;49(2):254-66.
1988: R K Wolff; Edward B Barr; J A Bond; A F Eidson; WC Griffith; Fletcher F Hahn; Jack R Harkema; Rogene F Henderson; C E Mitchell; S J Rothenberg
Factors affecting possible carcinogenicity of inhaled nitropyrene aerosols.
Research report (Health Effects Institute) 1988;(19):1-36.
1988: J A Bond; Jack R Harkema; V I Russell
Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(1):116-24.
1987: Jack R Harkema; Charles G Plopper; Dallas M Hyde; Dennis W Wilson; J A St George; Viviana J Wong
Nonolfactory surface epithelium of the nasal cavity of the bonnet monkey: a morphologic and morphometric study of the transitional and respiratory epithelium.
The American journal of anatomy 1987;180(3):266-79.
1987: Jack R Harkema; Charles G Plopper; Dallas M Hyde; J A St George; Dennis W Wilson; D L Dungworth
Response of the macaque nasal epithelium to ambient levels of ozone. A morphologic and morphometric study of the transitional and respiratory epithelium.
The American journal of pathology 1987;128(1):29-44.
1987: Jack R Harkema; Charles G Plopper; Dallas M Hyde; J A St George; D L Dungworth
Effects of an ambient level of ozone on primate nasal epithelial mucosubstances. Quantitative histochemistry.
The American journal of pathology 1987;127(1):90-6.
1985: G A Rao; E C Larkin; Jack R Harkema; D L Dungworth
Changes in lipids of lung lavage in monkeys after chronic exposure to ambient levels of ozone.
Toxicology letters 1985;29(2-3):207-14.
1985: G A Rao; E C Larkin; Jack R Harkema; D L Dungworth
Changes in the levels of polyunsaturated fatty acids in the lung and lecithin cholesterol acyl transferase activity in plasma of monkeys exposed to ambient levels of ozone.
Toxicology letters 1985;24(2-3):125-9.