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John Harlan

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R Angelo de Claro; Xiaodong Zhu; Jingjing Tang; Vicki Morgan-Stevenson; Barbara R Schwartz; Akiko Iwata; W Conrad Liles; Elaine W Raines; John M Harlan
Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.
Priya Handa; Katherine C Jordan; Joan C Tupper; John M Harlan
FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling.
Akiko Iwata; R Angelo de Claro; Vicki L Morgan-Stevenson; Joan C Tupper; Barbara R Schwartz; Li Liu; Xiaodong Zhu; Katherine C Jordan; Robert K Winn; John M Harlan
Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis.

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2011: R Angelo de Claro; Xiaodong Zhu; Jingjing Tang; Vicki Morgan-Stevenson; Barbara R Schwartz; Akiko Iwata; W Conrad Liles; Elaine W Raines; John M Harlan
Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.
The American journal of pathology 2011;178(6):2931-7.
2011: Priya Handa; Katherine C Jordan; Joan C Tupper; John M Harlan
FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling.
Cell communication and signaling : CCS 2011;9():16.
2011: Akiko Iwata; R Angelo de Claro; Vicki L Morgan-Stevenson; Joan C Tupper; Barbara R Schwartz; Li Liu; Xiaodong Zhu; Katherine C Jordan; Robert K Winn; John M Harlan
Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis.
PloS one 2011;6(2):e14729.
2010: Yu-Hua Chow; Xiao Dong Zhu; Li Liu; Barbara R Schwartz; Xiao Zhu Huang; John M Harlan; Lynn M Schnapp
Role of Cdk4 in lymphocyte function and allergen response.
Cell cycle (Georgetown, Tex.) 2010;9(24):4922-30.
2009: Pamela S Becker; Kenneth J Kopecky; Adrianne N Wilks; Sylvia Chien; John M Harlan; Cheryl L Willman; Stephen H Petersdorf; Derek L Stirewalt; Thalia Papayannopoulou; Frederick R Appelbaum
Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia.
Blood 2009;113(4):866-74.
2008: Li Liu; Barbara Schwartz; Yoshiaki Tsubota; Elaine W Raines; Hiroaki Kiyokawa; Karyn Yonekawa; John M Harlan; Lynn M Schnapp
Cyclin-dependent kinase inhibitors block leukocyte adhesion and migration.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1808-17.
2007: Emma L Taylor; John T Li; Joan C Tupper; Adriano G Rossi; Robert K Winn; John M Harlan
GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells.
Biochemical pharmacology 2007;74(7):1039-49.
2007: William A Altemeier; Xiaodong Zhu; William Berrington; John M Harlan; W Conrad Liles
Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway.
Journal of leukocyte biology 2007;82(3):721-8.
2005: Karyn Yonekawa; John M Harlan
Targeting leukocyte integrins in human diseases.
Journal of leukocyte biology 2005;77(2):129-40.
2004: Gary J Vanasse; Robert K Winn; Sofya Rodov; Arthur W Zieske; John T Li; Joan C Tupper; Jingjing Tang; Elaine W Raines; Mette A Peters; Ka Yee Yeung; John M Harlan
Bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and de novo follicular lymphoma.
Molecular cancer research : MCR 2004;2(11):620-31.
2004: Anthony M Avellino; Andrew T Dailey; John M Harlan; Sam R Sharar; Robert K Winn; Lawrence D McNutt; Michel Kliot
Blocking of up-regulated ICAM-1 does not prevent macrophage infiltration during Wallerian degeneration of peripheral nerve.
Experimental neurology 2004;187(2):430-44.
2004: Joan G Clark; Janis B Mandac-Dy; Anne E Dixon; David K Madtes; Kristin M Burkhart; John M Harlan; Daniel C Bullard
Trafficking of Th1 cells to lung: a role for selectins and a P-selectin glycoprotein-1-independent ligand.
American journal of respiratory cell and molecular biology 2004;30(2):220-7.
2003: Akiko Iwata; Vicki Morgan Stevenson; Annie Minard; Michael Tasch; Joan C Tupper; Eric Lagasse; Irving Weissman; John M Harlan; Robert K Winn
Over-expression of Bcl-2 provides protection in septic mice by a trans effect.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3136-41.
2003: Ryan D Erwert; Kristine T Eiting; Joan C Tupper; Robert K Winn; John M Harlan; Douglas D Bannerman
Shiga toxin induces decreased expression of the anti-apoptotic protein Mcl-1 concomitant with the onset of endothelial apoptosis.
Microbial pathogenesis 2003;35(2):87-93.
2003: Xianwu Li; Joan C Tupper; Douglas D Bannerman; Robert K Winn; Christopher J Rhodes; John M Harlan
Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.
Infection and immunity 2003;71(8):4414-20.
2003: Akiko Iwata; Kazumi Nishio; Robert K Winn; Emil Y Chi; William R Henderson; John M Harlan
A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3386-91.
2003: Chien-Ying Liu; Akihiro Takemasa; W Conrad Liles; Richard B Goodman; Mechthild Jonas; Henry Rosen; Emil Y Chi; Robert K Winn; John M Harlan; Peter I Chuang
Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils.
Blood 2003;101(1):295-304.
2002: Ryan D Erwert; Robert K Winn; John M Harlan; Douglas D Bannerman
Shiga-like toxin inhibition of FLICE-like inhibitory protein expression sensitizes endothelial cells to bacterial lipopolysaccharide-induced apoptosis.
The Journal of biological chemistry 2002;277(43):40567-74.
2002: Li Liu; Barbara R Schwartz; Joan C Tupper; Nancy Lin; Robert K Winn; John M Harlan
The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion.
The Journal of biological chemistry 2002;277(43):40893-900.
2002: Akiko Iwata; John M Harlan; Nicholas B Vedder; Robert K Winn
The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials.
Blood 2002;100(6):2077-80.
2002: Li Liu; Barbara R Schwartz; Nancy Lin; Robert K Winn; John M Harlan
Requirement for RhoA kinase activation in leukocyte de-adhesion.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2330-6.
2002: Douglas D Bannerman; Ryan D Erwert; Robert K Winn; John M Harlan
TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells.
Biochemical and biophysical research communications 2002;295(1):157-62.
2002: Xianwu Li; Li Liu; Joan C Tupper; Douglas D Bannerman; Robert K Winn; Said M Sebti; Andrew D Hamilton; John M Harlan
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
The Journal of biological chemistry 2002;277(18):15309-16.
2002: John M Harlan; Robert K Winn
Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy.
Critical care medicine 2002;30(5 Suppl):S214-9.
2002: Peter I Chuang; Samantha Morefield; Chien-Ying Liu; Stephen Chen; John M Harlan; Dennis M Willerford
Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1.
Blood 2002;99(9):3350-9.
2002: Douglas D Bannerman; Joan C Tupper; Ryan D Erwert; Robert K Winn; John M Harlan
Divergence of bacterial lipopolysaccharide pro-apoptotic signaling downstream of IRAK-1.
The Journal of biological chemistry 2002;277(10):8048-53.
2002: Douglas D Bannerman; Joan C Tupper; James D Kelly; Robert K Winn; John M Harlan
The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta.
The Journal of clinical investigation 2002;109(3):419-25.
2001: Douglas D Bannerman; Joan C Tupper; W A Ricketts; C F Bennett; Robert K Winn; John M Harlan
A constitutive cytoprotective pathway protects endothelial cells from lipopolysaccharide-induced apoptosis.
The Journal of biological chemistry 2001;276(18):14924-32.
2001: Thalia Papayannopoulou; Gregory V Priestley; Betty Nakamoto; V Zafiropoulos; Linda Maree SCOTT; John M Harlan
Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice.
Blood 2001;97(5):1282-8.
2001: Kyra Becker; Darin L Kindrick; J Relton; John M Harlan; Robert Winn
Antibody to the alpha4 integrin decreases infarct size in transient focal cerebral ischemia in rats.
Stroke; a journal of cerebral circulation 2001;32(1):206-11.
2000: John M Harlan
Introduction: anti-adhesion therapy in sickle cell disease.
Blood 2000;95(2):365-7.
2000: YP Rochon; T J Kavanagh; John M Harlan
Analysis of integrin (CD11b/CD18) movement during neutrophil adhesion and migration on endothelial cells.
Journal of microscopy 2000;197(Pt 1):15-24.
1999: L Liu; P Moesner; N L Kovach; R Bailey; A D Hamilton; S M Sebti; John M Harlan
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s).
The Journal of biological chemistry 1999;274(47):33334-40.
1999: K Zen; Aly Karsan; April Stempien-Otero; E Yee; Joan C Tupper; Xianwu Li; T Eunson; Mark A Kay; Christopher B Wilson; Robert K Winn; John M Harlan
NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide.
The Journal of biological chemistry 1999;274(40):28808-15.
1999: T Bombeli; Barbara R Schwartz; John M Harlan
Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets.
Blood 1999;93(11):3831-8.
1999: Barbara R Schwartz; Aly Karsan; T Bombeli; John M Harlan
A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4842-8.
1999: April Stempien-Otero; Aly Karsan; Carol Cornejo; H Xiang; T Eunson; R S Morrison; M Kay; Robert Winn; John M Harlan
Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis.
The Journal of biological chemistry 1999;274(12):8039-45.
1998: X Hu; E Yee; John M Harlan; Fred Wong; Aly Karsan
Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells.
Blood 1998;92(8):2759-65.
1998: K Zen; Aly Karsan; T Eunson; E Yee; John M Harlan
Lipopolysaccharide-induced NF-kappaB activation in human endothelial cells involves degradation of IkappaBalpha but not IkappaBbeta.
Experimental cell research 1998;243(2):425-33.
1998: S R Heckbert; Nicholas B Vedder; W Hoffman; Robert K Winn; L D Hudson; Gregory J Jurkovich; Michael K Copass; John M Harlan; C L Rice; Ronald V Maier
Outcome after hemorrhagic shock in trauma patients.
The Journal of trauma 1998;45(3):545-9.
1998: Peter I Chuang; E Yee; Aly Karsan; Robert K Winn; John M Harlan
A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils.
Biochemical and biophysical research communications 1998;249(2):361-5.
1998: K B Choi; Fred Wong; John M Harlan; P M Chaudhary; L Hood; Aly Karsan
Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway.
The Journal of biological chemistry 1998;273(32):20185-8.
1998: G A Talbott; Sam R Sharar; J C Paulson; John M Harlan; Robert K Winn
Antibiotic therapy determines subcutaneous Escherichia coli abscess formation after CD18 inhibition in rabbits.
The Journal of burn care & rehabilitation 1998;19(4):284-91.
1998: Aly Karsan; Carol Cornejo; Robert K Winn; Barbara R Schwartz; W Way; N Lannir; R Gershoni-Baruch; A Etzioni; H D Ochs; John M Harlan
Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium.
The Journal of clinical investigation 1998;101(11):2438-45.
1998: Robert Winn; Nicholas B Vedder; Chandra Ramamoorthy; Sam R Sharar; John M Harlan
Endothelial and leukocyte adhesion molecules in inflammation and disease.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9 Suppl 2():S17-23.
1998: T Bombeli; Barbara R Schwartz; John M Harlan
Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalpha.
The Journal of experimental medicine 1998;187(3):329-39.
1997: Robert K Winn; Chandra Ramamoorthy; Nicholas B Vedder; Sam R Sharar; John M Harlan
Leukocyte-endothelial cell interactions in ischemia-reperfusion injury.
Annals of the New York Academy of Sciences 1997;832():311-21.
1997: William R Henderson; Emil Y Chi; Richard Albert; S J Chu; Wayne J E Lamm; YP Rochon; Mechthild Jonas; Pandora E Christie; John M Harlan
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
The Journal of clinical investigation 1997;100(12):3083-92.
1997: Aly Karsan; E Yee; G G Poirier; P Zhou; R Craig; John M Harlan
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms.
The American journal of pathology 1997;151(6):1775-84.
1997: Peter I Chuang; B A Young; Ravi R Thiagarajan; Carol Cornejo; Robert K Winn; John M Harlan
Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal.
The Journal of biological chemistry 1997;272(40):24813-8.
1997: Heikki Repo; YP Rochon; Barbara R Schwartz; Sam R Sharar; Robert K Winn; John M Harlan
Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin (CD62E) does not promote their activation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):943-51.
1997: Ravi R Thiagarajan; Robert K Winn; John M Harlan
The role of leukocyte and endothelial adhesion molecules in ischemia-reperfusion injury.
Thrombosis and haemostasis 1997;78(1):310-4.
1997: T Bombeli; Aly Karsan; Jonathan F Tait; John M Harlan
Apoptotic vascular endothelial cells become procoagulant.
Blood 1997;89(7):2429-42.
1997: Chandra Ramamoorthy; W D Kovarik; Robert K Winn; John M Harlan; Sam R Sharar
Neutrophil adhesion molecule expression is comparable in perinatal rabbits and humans.
Anesthesiology 1997;86(2):420-7.
1997: Chandra Ramamoorthy; S S Sasaki; D L Su; Sam R Sharar; John M Harlan; Robert K Winn
CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus.
Journal of leukocyte biology 1997;61(2):167-72.
1997: Carol Cornejo; Robert K Winn; John M Harlan
Anti-adhesion therapy.
Advances in pharmacology (San Diego, Calif.) 1997;39():99-142.
1996: Chandra Ramamoorthy; Sam R Sharar; John M Harlan; T F Tedder; Robert K Winn
Blocking L-selectin function attenuates reperfusion injury following hemorrhagic shock in rabbits.
The American journal of physiology 1996;271(5 Pt 2):H1871-7.
1996: Aly Karsan; E Yee; John M Harlan
Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1.
The Journal of biological chemistry 1996;271(44):27201-4.
1996: Sam R Sharar; N N Chapman; L C Flaherty; John M Harlan; T F Tedder; Robert K Winn
L-selectin (CD62L) blockade does not impair peritoneal neutrophil emigration or subcutaneous host defense to bacteria in rabbits.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2555-63.
1996: Aly Karsan; E Yee; Kenneth Kaushansky; John M Harlan
Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.
Blood 1996;87(8):3089-96.
1996: J Seki; N Koyama; N L Kovach; T Yednock; Alexander W Clowes; John M Harlan
Regulation of beta1-integrin function in cultured human vascular smooth muscle cells.
Circulation research 1996;78(4):596-605.
1996: N Koyama; J Seki; SM Vergel; E J Mattsson; T Yednock; N L Kovach; John M Harlan; Alexander W Clowes
Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro.
The American journal of pathology 1996;148(3):749-61.
1996: Aly Karsan; John M Harlan
Modulation of endothelial cell apoptosis: mechanisms and pathophysiological roles.
Journal of atherosclerosis and thrombosis 1996;3(2):75-80.
1995: J M McCarty; E K Yee; T A Deisher; John M Harlan; K Kaushansky
Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NF-kappa b-independent mechanism.
FEBS letters 1995;372(2-3):194-8.
1995: Robert K Winn; Sam R Sharar; Nicholas B Vedder; John M Harlan
Leukocyte and endothelial adhesion molecules in ischaemia/reperfusion injuries.
Ciba Foundation symposium 1995;189():63-71; discussion 72-6, 77-8.
1995: N L Kovach; N Lin; T Yednock; John M Harlan; Virginia C Broudy
Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines.
Blood 1995;85(1):159-67.
1994: Robert K Winn; J C Paulson; John M Harlan
A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits.
The American journal of physiology 1994;267(6 Pt 2):H2391-7.
1994: G A Talbott; Sam R Sharar; John M Harlan; Robert K Winn
Leukocyte-endothelial interactions and organ injury: the role of adhesion molecules.
New horizons (Baltimore, Md.) 1994;2(4):545-54.
1994: N L Kovach; CG Lindgren; Alexander Fefer; JA Thompson; T Yednock; John M Harlan
Pentoxifylline inhibits integrin-mediated adherence of interleukin-2- activated human peripheral blood lymphocytes to human umbilical vein endothelial cells, matrix components, and cultured tumor cells.
Blood 1994;84(7):2234-42.
1994: D Mihelcic; B Schleiffenbaum; T F Tedder; Sam R Sharar; John M Harlan; Robert K Winn
Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear.
Blood 1994;84(7):2322-8.
1994: Thomas H Price; Hans D Ochs; R Gershoni-Baruch; John M Harlan; A Etzioni
In vivo neutrophil and lymphocyte function studies in a patient with leukocyte adhesion deficiency type II.
Blood 1994;84(5):1635-9.
1994: Sam R Sharar; D D Mihelcic; K T Han; John M Harlan; Robert K Winn
Ischemia reperfusion injury in the rabbit ear is reduced by both immediate and delayed CD18 leukocyte adherence blockade.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2234-8.
1994: J McFeely; L Embree; John M Harlan; R Albert
Adhesion to fibronectin augments tumor necrosis factor production by human alveolar macrophages.
Chest 1994;105(3 Suppl):100S-101S.
1994: S S Sasaki; Sam R Sharar; John M Harlan; C L Rice; Robert K Winn
Mild hemorrhagic shock does not enhance the risk of CD18 blockade to S. aureus skin inoculations.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(1):86-90.
1993: Sam R Sharar; S S Sasaki; L C Flaherty; J C Paulson; John M Harlan; Robert K Winn
P-selectin blockade does not impair leukocyte host defense against bacterial peritonitis and soft tissue infection in rabbits.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4982-8.
1993: T A Deisher; T L Haddix; K F Montgomery; Timothy H Pohlman; K Kaushansky; John M Harlan
The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells.
FEBS letters 1993;331(3):285-90.
1993: Robert K Winn; D Liggitt; Nicholas B Vedder; J C Paulson; John M Harlan
Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear.
The Journal of clinical investigation 1993;92(4):2042-7.
1993: Charles E Alpers; Kelly Hudkins; Connie L Davis; Christopher L Marsh; W Riches; J M McCarty; Christopher D Benjamin; T M Carlos; John M Harlan; Roy R Lobb
Expression of vascular cell adhesion molecule-1 in kidney allograft rejection.
Kidney international 1993;44(4):805-16.
1993: Robert K Winn; John M Harlan
CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.
The Journal of clinical investigation 1993;92(3):1168-73.
1993: T A Deisher; K Kaushansky; John M Harlan
Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells.
Cell adhesion and communication 1993;1(2):133-42.
1993: Robert K Winn; D Mihelicic; Nicholas B Vedder; Sam R Sharar; John M Harlan
Monoclonal antibodies to leukocyte and endothelial adhesion molecules attenuate ischemia-reperfusion injury.
Behring Institute Mitteilungen 1993;(92):229-37.
1993: Kevin D O'Brien; Margaret D Allen; T O McDonald; Alan Chait; John M Harlan; D Fishbein; J McCarty; M Ferguson; Kelly Hudkins; Christopher D Benjamin
Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.
The Journal of clinical investigation 1993;92(2):945-51.
1993: T A Deisher; T T Sato; Timothy H Pohlman; John M Harlan
A protein kinase C agonist, selective for the beta I isozyme, induces E-selectin and VCAM-1 expression on HUVEC but does not translocate PKC.
Biochemical and biophysical research communications 1993;193(3):1283-90.
1993: John M Harlan
Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration.
Clinical immunology and immunopathology 1993;67(3 Pt 2):S16-24.
1993: L A Langdale; L C Flaherty; H D Liggitt; John M Harlan; C L Rice; Robert K Winn
Neutrophils contribute to hepatic ischemia-reperfusion injury by a CD18-independent mechanism.
Journal of leukocyte biology 1993;53(5):511-7.
1993: W J Mileski; J F Raymond; Robert K Winn; John M Harlan; C L Rice
Inhibition of leukocyte adherence and aggregation for treatment of severe cold injury in rabbits.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(3):1432-6.
1993: Robert K Winn; W J Mileski; N L Kovach; Claire Doerschuk; C L Rice; John M Harlan
Role of protein synthesis and CD11/CD18 adhesion complex in neutrophil emigration into the lung.
Experimental lung research 1993;19(2):221-35.
1993: C E Bacchi; Christopher L Marsh; James D Perkins; Robert L Carithers; John P McVicar; Kelly Hudkins; Christopher D Benjamin; John M Harlan; Roy R Lobb; Charles E Alpers
Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection.
The American journal of pathology 1993;142(2):579-91.
1993: T A Deisher; I Garcia; John M Harlan
Cytokine-induced adhesion molecule expression on human umbilical vein endothelial cells is not regulated by cyclic adenosine monophosphate accumulation.
Life sciences 1993;53(4):365-70.
1993: Robert K Winn; Nicholas B Vedder; D Mihelcic; L C Flaherty; L Langdale; John M Harlan
The role of adhesion molecules in reperfusion injury.
Agents and actions. Supplements 1993;41():113-26.
1992: J R Thomas; John M Harlan; C L Rice; Robert K Winn
Role of leukocyte CD11/CD18 complex in endotoxic and septic shock in rabbits.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(4):1510-6.
1992: W J Mileski; Robert K Winn; John M Harlan; C L Rice
Sensitivity to endotoxin in rabbits is increased after hemorrhagic shock.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(3):1146-9.
1992: Michael J Bishop; T F Kowalski; S M Guidotti; John M Harlan
Antibody against neutrophil adhesion improves reperfusion and limits alveolar infiltrate following unilateral pulmonary artery occlusion.
The Journal of surgical research 1992;52(3):199-204.
1992: N L Kovach; T M Carlos; E Yee; John M Harlan
A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components.
The Journal of cell biology 1992;116(2):499-509.
1991: John M Harlan; Nicholas B Vedder; Robert K Winn; C L Rice
Mechanisms and consequences of leukocyte-endothelial interaction.
The Western journal of medicine 1991;155(4):365-9.
1991: K F Montgomery; L Osborn; Cathy Hession; R Tizard; D Goff; C Vassallo; P I Tarr; Karol Bomsztyk; Roy R Lobb; John M Harlan
Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6523-7.
1991: Sam R Sharar; Robert K Winn; Charles E Murry; John M Harlan; C L Rice
A CD18 monoclonal antibody increases the incidence and severity of subcutaneous abscess formation after high-dose Staphylococcus aureus injection in rabbits.
Surgery 1991;110(2):213-9; discussion 219-20.
1991: Aldo Dobrina; RENZO MENEGAZZI; T M Carlos; E Nardon; Rita Cramer; T Zacchi; John M Harlan; Pierluigi Patriarca
Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor.
The Journal of clinical investigation 1991;88(1):20-6.
1991: T Carlos; N Kovach; B Schwartz; M Rosa; B Newman; E Wayner; C Benjamin; L Osborn; Roy R Lobb; John M Harlan
Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1.
Blood 1991;77(10):2266-71.
1991: W J Mileski; Robert K Winn; John M Harlan; C L Rice
Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis.
Surgery 1991;109(4):497-501.
1990: T M Carlos; Aldo Dobrina; R Ross; John M Harlan
Multiple receptors on human monocytes are involved in adhesion to cultured human endothelial cells.
Journal of leukocyte biology 1990;48(5):451-6.
1990: W J Mileski; Robert K Winn; Nicholas B Vedder; Timothy H Pohlman; John M Harlan; C L Rice
Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates.
Surgery 1990;108(2):206-12.
1990: N L Kovach; E Yee; Robert Munford; C R Raetz; John M Harlan
Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo.
The Journal of experimental medicine 1990;172(1):77-84.
1990: W Mileski; John M Harlan; C Rice; Robert Winn
Streptococcus pneumoniae-stimulated macrophages induce neutrophils to emigrate by a CD18-independent mechanism of adherence.
Circulatory shock 1990;31(3):259-67.
1990: Barbara R Schwartz; E A Wayner; T M Carlos; Hans D Ochs; John M Harlan
Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.
The Journal of clinical investigation 1990;85(6):2019-22.
1990: T M Carlos; John M Harlan
Membrane proteins involved in phagocyte adherence to endothelium.
Immunological reviews 1990;114():5-28.
1990: Nicholas B Vedder; Robert K Winn; C L Rice; Emil Y Chi; K E Arfors; John M Harlan
Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2643-6.
1990: Claire Doerschuk; Robert K Winn; Harvey O Coxson; John M Harlan
CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2327-33.
1990: Aldo Dobrina; T M Carlos; Barbara R Schwartz; P G Beatty; Hans D Ochs; John M Harlan
Phorbol ester causes down-regulation of CD11/CD18-independent neutrophil adherence to endothelium.
Immunology 1990;69(3):429-34.
1989: Barbara R Schwartz; John M Harlan
Sulfhydryl reducing agents promote neutrophil adherence without increasing surface expression of CD11b/CD18 (Mac-1, Mo1).
Biochemical and biophysical research communications 1989;165(1):51-7.
1989: Nicholas B Vedder; B W Fouty; Robert K Winn; John M Harlan; C L Rice
Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock.
Surgery 1989;106(3):509-16.
1989: Aldo Dobrina; Barbara R Schwartz; T M Carlos; Hans D Ochs; P G Beatty; John M Harlan
CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro.
Immunology 1989;67(4):502-8.
1989: Timothy H Pohlman; John M Harlan
Human endothelial cell response to lipopolysaccharide, interleukin-1, and tumor necrosis factor is regulated by protein synthesis.
Cellular immunology 1989;119(1):41-52.
1989: Barbara R Schwartz; John M Harlan
Neutrophil membrane sulfhydryl groups are involved in stimulated neutrophil adherence to endothelium.
Journal of leukocyte biology 1989;45(3):177-82.
1988: Kenneth Kaushansky; Virginia C Broudy; John M Harlan; J W Adamson
Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3410-5.
1988: Timothy H Pohlman; Robert K Winn; K S Callahan; Ronald V Maier; John M Harlan
A glycolipid precursor of bacterial lipopolysaccharide (lipid X) lacks activity against endothelial cells in vitro and is not toxic in vivo.
The Journal of surgical research 1988;45(2):228-37.
1988: Nicholas B Vedder; Robert K Winn; C L Rice; Emil Y Chi; K E Arfors; John M Harlan
A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits.
The Journal of clinical investigation 1988;81(3):939-44.
1988: Nicholas B Vedder; John M Harlan
Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.
The Journal of clinical investigation 1988;81(3):676-82.
1987: C S Chen; Perumal Thiagarajan; Stephen M Schwartz; John M Harlan; R L Heimark
The platelet glycoprotein IIb/IIIa-like protein in human endothelial cells promotes adhesion but not initial attachment to extracellular matrix.
The Journal of cell biology 1987;105(4):1885-92.
1987: Robert Winn; R Maunder; John M Harlan
Lung lymph flow after bone marrow injection into goats was reduced by indomethacin.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(2):762-7.
1987: Robert Winn; R Maunder; E Chi; John M Harlan
Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(1):116-21.
1986: Robert Winn; J Gleisner; R Maunder; John M Harlan; J Hildebrant
Lung permeability and hemodynamics during endotoxemia: effect of aprotinin.
The Journal of surgical research 1986;41(6):620-6.
1986: S Price; John M Harlan; C J Carrico; J Hildebrandt; Robert Winn
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
The Journal of surgical research 1986;41(2):189-97.
1985: John M Harlan; Paul D Killen; F M Senecal; B R Schwartz; E Yee; R F Taylor; P G Beatty; T H Price; H D Ochs
The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro.
Blood 1985;66(1):167-78.
1983: Robert Winn; John M Harlan; B Nadir; L Harker; J Hildebrandt
Thromboxane A2 mediates lung vasoconstriction but not permeability after endotoxin.
The Journal of clinical investigation 1983;72(3):911-8.
1983: John M Harlan; Robert Winn; J Weaver; J Hildebrandt; L Harker
Selective blockade of thromboxane A2 synthesis during experimental E coli bacteremia in the goat. Effects on hemodynamics and lung water.
Chest 1983;83(5 Suppl):75S-76S.
1983: John M Harlan; Robert Winn; J Hildebrandt; L Harker
Selective inhibition of thromboxane synthesis during experimental endotoxemia in the goat: effects on pulmonary haemodynamics and lung lymph flow.
British journal of clinical pharmacology 1983;15 Suppl 1():123S-126S.