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John Harney

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Bo Zhu; Anulika Bhadouria; Ting Chen; John W Harney; P. Reed larsen; Cristina Luongo; Alessandro Marsili; Radhika Mopala; Ashutosh Shrivastava; Amanda I Steen; Thuy-Van Tran; Ann Marie Zavacki
Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation.
Alessandro Marsili; Domenico Salvatore; Prabhat Singh; Dan Tang; Ann Marie Zavacki; Monica Dentice; John W Harney; P. Reed larsen
Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle.
Alessandro Marsili; Edith Sanchez; Praful Singru; Ann Marie Zavacki; John W Harney; Ronald M Lechan; P Reed Larsen
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.

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All Publications

2012: Bo Zhu; Anulika Bhadouria; Ting Chen; John W Harney; P. Reed larsen; Cristina Luongo; Alessandro Marsili; Radhika Mopala; Ashutosh Shrivastava; Amanda I Steen; Thuy-Van Tran; Ann Marie Zavacki
Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation.
The Journal of endocrinology 2012;214(1):87-94.
2011: Alessandro Marsili; Domenico Salvatore; Prabhat Singh; Dan Tang; Ann Marie Zavacki; Monica Dentice; John W Harney; P. Reed larsen
Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2011;301(5):E818-24.
2011: Alessandro Marsili; Edith Sanchez; Praful Singru; Ann Marie Zavacki; John W Harney; Ronald M Lechan; P Reed Larsen
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.
The Journal of endocrinology 2011;211(1):73-8.
2011: A Marsili; Ann Marie Zavacki; John W Harney; P Reed Larsen
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.
Journal of endocrinological investigation 2011;34(5):395-407.
2011: Alessandro Marsili; Waile Ramadan; Jorge Enrique Silva; Thuy Van-Tran; Cristina Aguayo-Mazzucato; Susan Bonner-Weir; Ting Chen; Cyril Chou; Mirra Chung; Elena Gianetti; John W Harney; Aditi Kumar; Philip Reed Larsen; Elaine P Lunsford; Ann Marie Zavacki
Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.
PloS one 2011;6(6):e20832.
2010: Alessandro Marsili; Waile Ramadan; John W Harney; Michelle Mulcahey; Luciana Audi Castroneves; Iuri Martin Goemann; Simone Magagnin Wajner; Stephen A Huang; Ann Marie Zavacki; Ana Luiza Maia; Monica Dentice; Domenico Salvatore; J Enrique Silva; P Reed Larsen
Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.
Endocrinology 2010;151(12):5952-60.
2009: Goele Aerts; Rafael Arrojo E Drigo; Stijn L J Van Herck; Eva Sammels; Delphine Mirebeau-Prunier; Balázs Gereben; Anikó Zeöld; John W Harney; Stephen A Huang; Michelle A Mulcahey; Serge Van Der Geyten; Gert Van den Bergh; Lutgarde Arckens; Veerle M Darras; Ann Marie Zavacki
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells.
Endocrinology 2009;150(11):5171-80.
2009: Ann Marie Zavacki; Rafael Arrojo E Drigo; Beatriz C G Freitas; Mirra Chung; John W Harney; Péter Egri; Gábor Wittmann; Csaba Fekete; Balázs Gereben; Antonio Bianco
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.
Molecular and cellular biology 2009;29(19):5339-47.
2008: G D Vivek Sagar; Balázs Gereben; Isabelle Callebaut; Jean-Paul Mornon; Anikó Zeöld; Cyntia Curcio-Morelli; John W Harney; Cristina Luongo; Michelle A Mulcahey; P Reed Larsen; Stephen A Huang; Antonio Bianco
The thyroid hormone-inactivating deiodinase functions as a homodimer.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1382-93.
2007: G D Vivek Sagar; Balázs Gereben; Isabelle Callebaut; Jean-Paul Mornon; Anikó Zeöld; Wagner S da-Silva; Cristina Luongo; Monica Dentice; Susana M Tente; Beatriz C G Freitas; John W Harney; Ann Marie Zavacki; Antonio Bianco
Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
Molecular and cellular biology 2007;27(13):4774-83.
2007: Nadya Morozova; Konstantin Khrapko; Jun Panee; Wanyu Liu; John W Harney; Marla J Berry
Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(5):561-7.
2007: Wagner S da-Silva; John W Harney; Brian W. Kim; Jing Li; Suzy Bianco; Alessandra Crescenzi; Marcelo A Christoffolete; Stephen A Huang; Antonio Bianco
The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
Diabetes 2007;56(3):767-76.
2006: Zoia Stoytcheva; Roza Tujebajeva; John W Harney; Marla J Berry
Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.
Molecular and cellular biology 2006;26(24):9177-84.
2006: Anikó Zeöld; Lívia Pormüller; Monica Dentice; John W Harney; Cyntia Curcio-Morelli; Susana M Tente; Antonio Bianco; Balázs Gereben
Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.
The Journal of biological chemistry 2006;281(42):31538-43.
2006: Marcelo A Christoffolete; Rogério Ribeiro; Praful Singru; Csaba Fekete; Wagner S da-Silva; David F Gordon; Stephen A Huang; Alessandra Crescenzi; John W Harney; E Chester Ridgway; P Reed Larsen; Ronald M Lechan; Antonio Bianco
Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
Endocrinology 2006;147(4):1735-43.
2006: Andrea Small-Howard; Nadya Morozova; Zoia Stoytcheva; Erin P Forry; John B Mansell; John W Harney; Bradley A Carlson; Xue-Ming Xu; Dolph L Hatfield; Marla J Berry
Supramolecular complexes mediate selenocysteine incorporation in vivo.
Molecular and cellular biology 2006;26(6):2337-46.
2006: Lucia A De Jesus; Peter R Hoffmann; Tanya Michaud; Erin P Forry; Andrea Small-Howard; Robert J Stillwell; Nadya Morozova; John W Harney; Marla J Berry
Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay?
Molecular and cellular biology 2006;26(5):1795-805.
2006: Mitsuhiro Watanabe; Sander M Houten; Chikage Mataki; Marcelo A Christoffolete; Brian W. Kim; Hiroyuki Sato; Nadia Messaddeq; John W Harney; Osamu Ezaki; Tatsuhiko Kodama; Kristina Schoonjans; Antonio Bianco; Johan Auwerx
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Nature 2006;439(7075):484-9.
2005: Stephen A Huang; Michelle A Mulcahey; Alessandra Crescenzi; Mirra Chung; Brian W. Kim; Carmen M. Barnes; Wichert Kuijt; Helen Turano; John W Harney; P Reed Larsen
Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3126-36.
2005: Ana Luiza Maia; Brian W. Kim; Stephen A Huang; John W Harney; P Reed Larsen
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.
The Journal of clinical investigation 2005;115(9):2524-33.
2005: Monica Dentice; Amitabha Bandyopadhyay; Balázs Gereben; Isabelle Callebaut; Marcelo A Christoffolete; Brian W. Kim; Sahar Nissim; Jean-Paul Mornon; Ann Marie Zavacki; Anikó Zeöld; Luciane P Capelo; Cyntia Curcio-Morelli; Rogério Ribeiro; John W Harney; Clifford J Tabin; Antonio Bianco
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Nature cell biology 2005;7(7):698-705.
2005: Luís Henrique Canani; Clarissa Capp; José Miguel Dora; Erika L Souza Meyer; Márcia S Wagner; John W Harney; P Reed Larsen; Jorge L Gross; Antonio Bianco; Ana Luiza Maia
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2005;90(6):3472-8.
2005: Sung-Woo Kim; Sung-Chul Ho; Seong-June Hong; Kyung Min Kim; Edward C So; Marcelo A Christoffolete; John W Harney
A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter.
The Journal of biological chemistry 2005;280(15):14545-55.
2005: Ann Marie Zavacki; Hao Ying; Marcelo A Christoffolete; Goele Aerts; Edward C So; John W Harney; Sheue-Yann Cheng; P Reed Larsen; Antonio Bianco
Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.
Endocrinology 2005;146(3):1568-75.
2005: Cecilia H A Gouveia; Marcelo A Christoffolete; Clarissa R Zaitune; José Miguel Dora; John W Harney; Ana Luiza Maia; Antonio Bianco
Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.
Endocrinology 2005;146(1):195-200.
2004: Sung-Woo Kim; Seong-June Hong; Kyung Min Kim; Sung-Chul Ho; Edward C So; John W Harney; P Reed Larsen
A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene.
Molecular endocrinology (Baltimore, Md.) 2004;18(12):2924-36.
2004: Suzy Bianco; Brian W. Kim; Julie X Zhang; John W Harney; Rogério S Ribeiro; Balázs Gereben; Antonio Bianco; Ulrike Mende; P Reed Larsen
Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1840-9.
2004: Csaba Fekete; Balázs Gereben; Marton Doleschall; John W Harney; José Miguel Dora; Antonio Bianco; Sumit Sarkar; Zsolt Liposits; William Rand; Charles Emerson; Imre Kacskovics; P Reed Larsen; Ronald M Lechan
Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.
Endocrinology 2004;145(4):1649-55.
2003: Nadya Morozova; Erin P Forry; Elena Shahid; Ann Marie Zavacki; John W Harney; Yevgenya Kraytsberg; Marla J Berry
Antioxidant function of a novel selenoprotein in Drosophila melanogaster.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(12):963-71.
2003: Brian W. Kim; Ann Marie Zavacki; Cyntia Curcio-Morelli; Monica Dentice; John W Harney; P Reed Larsen; Antonio Bianco
Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2603-12.
2003: Isabelle Callebaut; Cyntia Curcio-Morelli; Jean-Paul Mornon; Balázs Gereben; Christoph Buettner; Stephen Huang; Bertrand Castro; Tatiana L Fonseca; John W Harney; P Reed Larsen; Antonio Bianco
The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.
The Journal of biological chemistry 2003;278(38):36887-96.
2003: Cyntia Curcio-Morelli; Ann Marie Zavacki; Marcelo Christofollete; Balázs Gereben; Beatriz C G de Freitas; John W Harney; Zaibo Li; Guan Wu; Antonio Bianco
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
The Journal of clinical investigation 2003;112(2):189-96.
2003: Ann Marie Zavacki; John B Mansell; Mirra Chung; Boris Klimovitsky; John W Harney; Marla J Berry
Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus.
Molecular cell 2003;11(3):773-81.
2003: Cyntia Curcio-Morelli; Balázs Gereben; Ann Marie Zavacki; Brian W. Kim; Stephen Huang; John W Harney; P Reed Larsen; Antonio Bianco
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.
Endocrinology 2003;144(3):937-46.
2003: Brian W. Kim; G H Daniels; B J Harrison; A Price; John W Harney; P Reed Larsen; A P Weetman
Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels.
The Journal of clinical endocrinology and metabolism 2003;88(2):594-8.
2003: Munira Baqui; Diego Botero; Balázs Gereben; Cyntia Curcio; John W Harney; Domenico Salvatore; Kenji Sorimachi; P Reed Larsen; Antonio Bianco
Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
The Journal of biological chemistry 2003;278(2):1206-11.
2002: Diego Botero; Balázs Gereben; Carla Goncalves; Lucia A De Jesus; John W Harney; Antonio Bianco
Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):1999-2007.
2002: Balázs Gereben; Anna Kollár; John W Harney; P Reed Larsen
The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1667-79.
2002: Marla J Berry; Glover W Martin; Roza Tujebajeva; Elisabeth Grundner-Culemann; John B Mansell; Nadya Morozova; John W Harney
Selenocysteine insertion sequence element characterization and selenoprotein expression.
Methods in enzymology 2002;347():17-24.
2001: Lucia A De Jesus; Suzy Bianco; Miriam O Ribeiro; M Schneider; S W Kim; John W Harney; P Reed Larsen; Antonio Bianco
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
The Journal of clinical investigation 2001;108(9):1379-85.
2001: C Curcio; Munira Baqui; Domenico Salvatore; bertrand rihn; Steve Mohr; John W Harney; P Reed Larsen; Antonio Bianco
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
The Journal of biological chemistry 2001;276(32):30183-7.
2001: Elisabeth Grundner-Culemann; Glover W Martin; Roza Tujebajeva; John W Harney; Marla J Berry
Interplay between termination and translation machinery in eukaryotic selenoprotein synthesis.
Journal of molecular biology 2001;310(4):699-707.
2001: R Peeters; C Fekete; Carla Goncalves; Gabor Legradi; HM Tu; John W Harney; Antonio Bianco; Ronald M Lechan; P Reed Larsen
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
American journal of physiology. Endocrinology and metabolism 2001;281(1):E54-61.
2001: Marla J Berry; Roza Tujebajeva; Paul R Copeland; Xue-Ming Xu; Bradley A Carlson; Glover W Martin; SC Low; John B Mansell; Elisabeth Grundner-Culemann; John W Harney; Donna M Driscoll; Dolph L Hatfield
Selenocysteine incorporation directed from the 3'UTR: characterization of eukaryotic EFsec and mechanistic implications.
BioFactors (Oxford, England) 2001;14(1-4):17-24.
2001: Balázs Gereben; Domenico Salvatore; John W Harney; HM Tu; P Reed Larsen
The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1).
Molecular endocrinology (Baltimore, Md.) 2001;15(1):112-24.
2000: SC Low; Elisabeth Grundner-Culemann; John W Harney; Marla J Berry
SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy.
The EMBO journal 2000;19(24):6882-90.
2000: Christoph Buettner; John W Harney; P Reed Larsen
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase.
Endocrinology 2000;141(12):4606-12.
2000: Roza Tujebajeva; David G. Ransom; John W Harney; Marla J Berry
Expression and characterization of nonmammalian selenoprotein P in the zebrafish, Danio rerio.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(11):897-903.
2000: Munira Baqui; Balázs Gereben; John W Harney; P Reed Larsen; Antonio Bianco
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy.
Endocrinology 2000;141(11):4309-12.
2000: Balázs Gereben; Carla Goncalves; John W Harney; P Reed Larsen; Antonio Bianco
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
Molecular endocrinology (Baltimore, Md.) 2000;14(11):1697-708.
2000: Roza Tujebajeva; Paul R Copeland; Xue-Ming Xu; Bradley A Carlson; John W Harney; Donna M Driscoll; Dolph L Hatfield; Marla J Berry
Decoding apparatus for eukaryotic selenocysteine insertion.
EMBO reports 2000;1(2):158-63.
2000: Stephen A Huang; HM Tu; John W Harney; Maria Venihaki; Atul Butte; Harry P W Kozakewich; Steven J Fishman; P Reed Larsen
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas.
The New England journal of medicine 2000;343(3):185-9.
2000: Roza Tujebajeva; John W Harney; Marla J Berry
Selenoprotein P expression, purification, and immunochemical characterization.
The Journal of biological chemistry 2000;275(9):6288-94.
2000: J Steinsapir; Antonio Bianco; Christoph Buettner; John W Harney; P Reed Larsen
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
Endocrinology 2000;141(3):1127-35.
2000: T Bartha; S W Kim; Domenico Salvatore; Balázs Gereben; HM Tu; John W Harney; Péter Rudas; P Reed Larsen
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene.
Endocrinology 2000;141(1):229-37.
1999: Christoph Buettner; John W Harney; Marla J Berry
The Caenorhabditis elegans homologue of thioredoxin reductase contains a selenocysteine insertion sequence (SECIS) element that differs from mammalian SECIS elements but directs selenocysteine incorporation.
The Journal of biological chemistry 1999;274(31):21598-602.
1999: Balázs Gereben; T Bartha; HM Tu; John W Harney; Péter Rudas; P Reed Larsen
Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase.
The Journal of biological chemistry 1999;274(20):13768-76.
1999: Domenico Salvatore; John W Harney; P Reed Larsen
Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties.
Biochimie 1999;81(5):535-8.
1999: Elisabeth Grundner-Culemann; Glover W Martin; John W Harney; Marla J Berry
Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes.
RNA (New York, N.Y.) 1999;5(5):625-35.
1998: Christoph Buettner; John W Harney; P Reed Larsen
The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element.
The Journal of biological chemistry 1998;273(50):33374-8.
1998: J Steinsapir; John W Harney; P Reed Larsen
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes.
The Journal of clinical investigation 1998;102(11):1895-9.
1998: S W Kim; John W Harney; P Reed Larsen
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction.
Endocrinology 1998;139(12):4895-905.
1998: Chen-Yu zhang; S Kim; John W Harney; P Reed Larsen
Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene.
Endocrinology 1998;139(3):1156-63.
1998: Glover W Martin; John W Harney; Marla J Berry
Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide.
RNA (New York, N.Y.) 1998;4(1):65-73.
1997: B C Sun; John W Harney; Marla J Berry; P Reed Larsen
The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase.
Endocrinology 1997;138(12):5452-8.
1997: N Toyoda; E Kaptein; Marla J Berry; John W Harney; P Reed Larsen; T J Visser
Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases.
Endocrinology 1997;138(1):213-9.
1996: Domenico Salvatore; HM Tu; John W Harney; P Reed Larsen
Type 2 iodothyronine deiodinase is highly expressed in human thyroid.
The Journal of clinical investigation 1996;98(4):962-8.
1996: Ana Luiza Maia; John W Harney; P Reed Larsen
Is there a negative TRE in the luciferase reporter cDNA?
Thyroid : official journal of the American Thyroid Association 1996;6(4):325-8.
1996: Domenico Salvatore; T Bartha; John W Harney; P Reed Larsen
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase.
Endocrinology 1996;137(8):3308-15.
1996: A M Zavacki; John W Harney; G A Brent; P Reed Larsen
Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor.
Endocrinology 1996;137(7):2833-41.
1996: A M Zavacki; Chen-Yu zhang; John W Harney; P Reed Larsen
Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element.
Endocrinology 1996;137(4):1438-46.
1996: Glover W Martin; John W Harney; Marla J Berry
Selenocysteine incorporation in eukaryotes: insights into mechanism and efficiency from sequence, structure, and spacing proximity studies of the type 1 deiodinase SECIS element.
RNA (New York, N.Y.) 1996;2(2):171-82.
1995: Domenico Salvatore; S C Low; M Berry; Ana Luiza Maia; John W Harney; W Croteau; Donald L St Germain; P Reed Larsen
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.
The Journal of clinical investigation 1995;96(5):2421-30.
1995: Ana Luiza Maia; JD Kieffer; John W Harney; P Reed Larsen
Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice.
Endocrinology 1995;136(11):4842-9.
1995: S C Low; John W Harney; Marla J Berry
Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis.
The Journal of biological chemistry 1995;270(37):21659-64.
1995: N Toyoda; A M Zavacki; Ana Luiza Maia; John W Harney; P Reed Larsen
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene.
Molecular and cellular biology 1995;15(9):5100-12.
1995: Ana Luiza Maia; Marla J Berry; R Sabbag; John W Harney; P Reed Larsen
Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency.
Molecular endocrinology (Baltimore, Md.) 1995;9(8):969-80.
1995: N Toyoda; Marla J Berry; John W Harney; P Reed Larsen
Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1).
The Journal of biological chemistry 1995;270(20):12310-8.
1995: Ana Luiza Maia; John W Harney; P Reed Larsen
Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways.
Endocrinology 1995;136(4):1488-94.
1995: J H Hsu; A M Zavacki; John W Harney; G A Brent
Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content.
Endocrinology 1995;136(2):421-30.
1994: Marla J Berry; John W Harney; T Ohama; Dolph L Hatfield
Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon:codon mutations.
Nucleic acids research 1994;22(18):3753-9.
1994: N Toyoda; John W Harney; Marla J Berry; P Reed Larsen
Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes.
The Journal of biological chemistry 1994;269(32):20329-34.
1994: G R Williams; A M Zavacki; John W Harney; G A Brent
Thyroid hormone receptor binds with unique properties to response elements that contain hexamer domains in an inverted palindrome arrangement.
Endocrinology 1994;134(4):1888-96.
1993: A M Zavacki; John W Harney; G A Brent; P Reed Larsen
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1319-30.
1993: Marla J Berry; L Banu; John W Harney; P Reed Larsen
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons.
The EMBO journal 1993;12(8):3315-22.
1992: S J Mandel; Marla J Berry; JD Kieffer; John W Harney; R L Warne; P Reed Larsen
Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase.
The Journal of clinical endocrinology and metabolism 1992;75(4):1133-9.
1992: Marla J Berry; Ana Luiza Maia; JD Kieffer; John W Harney; P Reed Larsen
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation.
Endocrinology 1992;131(4):1848-52.
1992: G R Williams; John W Harney; David D Moore; P Reed Larsen; G A Brent
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1527-37.
1992: G A Brent; G R Williams; John W Harney; B M Forman; Herbert H Samuels; David D Moore; P Reed Larsen
Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements.
Molecular endocrinology (Baltimore, Md.) 1992;6(4):502-14.
1991: G R Williams; John W Harney; B M Forman; Herbert H Samuels; G A Brent
Oligomeric binding of T3 receptor is required for maximal T3 response.
The Journal of biological chemistry 1991;266(29):19636-44.
1991: Marla J Berry; L Banu; Y Y Chen; S J Mandel; JD Kieffer; John W Harney; P Reed Larsen
Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region.
Nature 1991;353(6341):273-6.
1991: Marla J Berry; JD Kieffer; John W Harney; P Reed Larsen
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase.
The Journal of biological chemistry 1991;266(22):14155-8.
1991: G A Brent; G R Williams; John W Harney; B M Forman; Herbert H Samuels; David D Moore; P Reed Larsen
Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine.
Molecular endocrinology (Baltimore, Md.) 1991;5(4):542-8.
1989: G A Brent; John W Harney; Y Chen; R L Warne; David D Moore; P Reed Larsen
Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):1996-2004.
1989: G A Brent; M K Dunn; John W Harney; T Gulick; P Reed Larsen; David D Moore
Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor.
The New biologist 1989;1(3):329-36.
1989: G A Brent; P Reed Larsen; John W Harney; Ronald J Koenig; David D Moore
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor.
The Journal of biological chemistry 1989;264(1):178-82.
1988: G A Brent; John W Harney; David D Moore; P Reed Larsen
Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 1988;2(9):792-8.
1988: Ronald J Koenig; R L Warne; G A Brent; John W Harney; P Reed Larsen; David D Moore
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5031-5.