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Wade Harper

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Peter C W Lee; Bruce A Yankner; Liviu Aron; Roderick T Bronson; Jean-Cosme Dodart; Lydia W Finley; Marcia Haigis; J Wade Harper
Altered social behavior and neuronal development in mice lacking the uba6-use1 ubiquitin transfer system.
Shireen A Sarraf; Mathew E Sowa; Virginia Guarani-Pereira; Steven P Gygi; Edward L Huttlin; Malavika Raman; J Wade Harper
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sean M Armour; Eric J Bennett; Craig R Braun; Steven P Gygi; J Wade Harper; Steven B McMahon; Xiao-Yong Zhang; David A Sinclair
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.

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2013: Peter C W Lee; Bruce A Yankner; Liviu Aron; Roderick T Bronson; Jean-Cosme Dodart; Lydia W Finley; Marcia Haigis; J Wade Harper
Altered social behavior and neuronal development in mice lacking the uba6-use1 ubiquitin transfer system.
Molecular cell 2013;50(2):172-84.
2013: Shireen A Sarraf; Mathew E Sowa; Virginia Guarani-Pereira; Steven P Gygi; Edward L Huttlin; Malavika Raman; J Wade Harper
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Nature 2013;496(7445):372-6.
2013: Sean M Armour; Eric J Bennett; Craig R Braun; Steven P Gygi; J Wade Harper; Steven B McMahon; Xiao-Yong Zhang; David A Sinclair
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology 2013;33(8):1487-502.
2013: Julie K Monda; Daniel C Scott; Eric J Bennett; J Wade Harper; David King; John Lydeard; Darcie J Miller; Brenda A Schulman
Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.
Structure (London, England : 1993) 2013;21(1):42-53.
2012: Elizabeth A White; J Wade Harper; Sebastian D Hayes; Rebecca E Kramer; Min Jie Alvin Tan; Peter M Howley
Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity.
Journal of virology 2012;86(24):13174-86.
2012: J Wade Harper; Meng-Kwang Marcus Tan
Understanding cullin-RING E3 biology through proteomics-based substrate identification.
Molecular & cellular proteomics : MCP 2012;11(12):1541-50.
2012: Anne E White; J Wade Harper
Cancer. Emerging anatomy of the BAP1 tumor suppressor system.
Science (New York, N.Y.) 2012;337(6101):1463-4.
2012: Takamune T Saito; J Wade Harper; Katherine Meyer; Firaz Mohideen; Mónica P Colaiácovo
SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.
PLoS genetics 2012;8(8):e1002888.
2012: Gustavo Martínez-Noël; Thomas M Overton; Mathew E Sowa; Verena Arndt; Jeffrey T Galligan; J Wade Harper; Peter M Howley
Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.
Molecular and cellular biology 2012;32(15):3095-106.
2012: Min Jie Alvin Tan; Elizabeth A White; Jon C Aster; J Wade Harper; Mathew E Sowa; Peter M Howley
Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):E1473-80.
2012: Doris Popovic; Masato Akutsu; Christian Behrends; J Wade Harper; Ivana Novak; Ivan Dikic
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
Molecular and cellular biology 2012;32(9):1733-44.
2012: Honghui Ma; Hao Chen; Jianbo Diao; Rui Guo; Xue Guo; J Wade Harper; Shibin Hu; Fei Lan; Yujiang Geno Shi; Mathew E Sowa; Zhentian Wang; Yanhui Xu; Pingyao Zeng; Lijuan Zheng; Yang Shi
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(13):4828-33.
2012: Elizabeth A White; J Wade Harper; Sebastian D Hayes; Sheila Jeudy; Karl Münger; Sreevidya Santha; Mathew E Sowa; Min Jie Alvin Tan; Peter M Howley
Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):E260-7.
2011: Sebastian Dango; Steve Gygi; J Wade Harper; Nima Mosammaparast; Keyjung Park; Mark Rubin; Mathew E Sowa; Feizhen Wu; Li-Jun Xiong; Yang Shi
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Molecular cell 2011;44(3):373-84.
2011: Daniel C Scott; Eric J Bennett; J Wade Harper; Julie K Monda; Brenda A Schulman
N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.
Science (New York, N.Y.) 2011;334(6056):674-8.
2011: Daming Gao; Steven P Gygi; J Wade Harper; Hiroyuki Inuzuka; Pengda Liu; Jason W Locasale; Costas A Lyssiotis; Shavali Shaik; Meng-Kwang Marcus Tan; Alex Toker; Lixin Wan; John M Asara; Lewis C Cantley; Y Rebecca Chin; Hidefumi Fukushima; Bo Zhai; Wenyi Wei
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Molecular cell 2011;44(2):290-303.
2011: Woong Kim; Jing Li; Anthony Possemato; Ramin Rad; John Rush; Mathew E Sowa; Eric J Bennett; Michael J Comb; Ailan Guo; J Wade Harper; Edward L Huttlin; Steven P Gygi
Systematic and quantitative assessment of the ubiquitin-modified proteome.
Molecular cell 2011;44(2):325-40.
2011: Malavika Raman; Johannes C Walter; Courtney G Havens; J Wade Harper
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
Molecular cell 2011;44(1):72-84.
2011: Meng-Kwang Marcus Tan; Hui-Jun Lim; J Wade Harper
SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.
Molecular and cellular biology 2011;31(18):3687-99.
2011: Peter C W Lee; Mathew E Sowa; Steven P Gygi; J Wade Harper
Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.
Molecular cell 2011;43(3):392-405.
2011: Eric J Bennett; J Wade Harper
Simply quantifying ubiquitin complexity.
Nature methods 2011;8(8):630-1.
2011: Shaila Rahman; Yang Shi; Jennifer A Smith; Mathew E Sowa; J Wade Harper; Matthias Ottinger; Peter M Howley
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Molecular and cellular biology 2011;31(13):2641-52.
2011: J Wade Harper; Randall W King
Stuck in the middle: drugging the ubiquitin system at the e2 step.
Cell 2011;145(7):1007-9.
2011: Cecilia Cotta-Ramusino; J Wade Harper; Kristen Hurov; E Robert McDonald; Mathew E Sowa; Stephen J Elledge
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Science (New York, N.Y.) 2011;332(6035):1313-7.
2011: Nadia Litterman; Yoshiho Ikeuchi; Gilbert Gallardo; Brenda C O'Connell; Mathew E Sowa; Steven P Gygi; J Wade Harper; Azad Bonni
An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
PLoS biology 2011;9(5):e1001060.
2011: Christian Behrends; J Wade Harper
Constructing and decoding unconventional ubiquitin chains.
Nature structural & molecular biology 2011;18(5):520-8.
2010: Eric J Bennett; John Rush; Steven P Gygi; J Wade Harper
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Cell 2010;143(6):951-65.
2010: Brenda C O'Connell; Britt Adamson; John R Lydeard; Mathew E Sowa; Alberto Ciccia; Andrea L Bredemeyer; Michael Schlabach; Steven P Gygi; Stephen J Elledge; J Wade Harper
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
Molecular cell 2010;40(4):645-57.
2010: Daming Gao; Lixin Wan; Hiroyuki Inuzuka; Anders H Berg; Alan Tseng; Bo Zhai; Shavali Shaik; Eric Bennett; Adriana E Tron; Jessica A Gasser; Alan Lau; Steven P Gygi; J Wade Harper; James A DeCaprio; Alex Toker; Wenyi Wei
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Molecular cell 2010;39(5):797-808.
2010: Hiroyuki Inuzuka; Alan Tseng; Daming Gao; Bo Zhai; Qing Zhang; Shavali Shaik; Lixin Wan; Xiaolu L Ang; Caroline Mock; Haoqiang Yin; Jayne M Stommel; Steven Gygi; Galit Lahav; John Asara; Zhi-Xiong Jim Xiao; William G Kaelin; J Wade Harper; Wenyi Wei
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
Cancer cell 2010;18(2):147-59.
2010: Agata Smogorzewska; Rohini Desetty; Takamune T Saito; Michael Schlabach; Francis P Lach; Mathew E Sowa; Alan B Clark; Thomas A Kunkel; J Wade Harper; Monica P Colaiácovo; Stephen J Elledge
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Molecular cell 2010;39(1):36-47.
2010: John R Lydeard; J Wade Harper
Inhibitors for E3 ubiquitin ligases.
Nature biotechnology 2010;28(7):682-4.
2010: Eun Joo Song; Shannon L Werner; Jakob Neubauer; Frank Stegmeier; Julie Aspden; Donald C Rio; J Wade Harper; Stephen J Elledge; Marc W Kirschner; Michael Rape
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
Genes & development 2010;24(13):1434-47.
2010: Christian Behrends; Mathew E Sowa; Steven P Gygi; J Wade Harper
Network organization of the human autophagy system.
Nature 2010;466(7302):68-76.
2010: Maria L C Powell; Jennifer A Smith; Mathew E Sowa; J Wade Harper; Thomas Iftner; Frank Stubenrauch; Peter M Howley
NCoR1 mediates papillomavirus E8;E2C transcriptional repression.
Journal of virology 2010;84(9):4451-60.
2010: Eric J Bennett; J Wade Harper
Ubiquitin gets CARDed.
Cell 2010;141(2):220-2.
2010: Sebastian D Hayes; J Wade Harper
Cdc25A and Dub3 in a high-stakes balancing act.
Nature cell biology 2010;12(4):311-3.
2010: Jennifer M Svendsen; J Wade Harper
GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.
Genes & development 2010;24(6):521-36.
2010: Jennifer A Smith; Elizabeth A White; Mathew E Sowa; Maria L C Powell; Matthias Ottinger; J Wade Harper; Peter M Howley
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3752-7.
2010: Shireen A Sarraf; J Wade Harper
Telomeric TuRF1 wars.
Developmental cell 2010;18(2):167-8.
2009: Malavika Raman; J Wade Harper
Cell biology: Stairway to the proteasome.
Nature 2009;462(7273):585-6.
2009: Alberto Ciccia; Andrea L Bredemeyer; Mathew E Sowa; Marie-Emilie Terret; Prasad V Jallepalli; J Wade Harper; Stephen J Elledge
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.
Genes & development 2009;23(20):2415-25.
2009: Min Zhuang; Matthew F Calabrese; Jiang Liu; M Brett Waddell; Amanda Nourse; Michal Hammel; Darcie J Miller; Helen Walden; David M Duda; Steven N Seyedin; Timothy Hoggard; J Wade Harper; Kevin P White; Brenda A Schulman
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Molecular cell 2009;36(1):39-50.
2009: Gang Zheng; Michal-Ruth Schweiger; Gustavo Martinez-Noel; Leon Zheng; Jennifer A Smith; J Wade Harper; Peter M Howley
Brd4 regulation of papillomavirus protein E2 stability.
Journal of virology 2009;83(17):8683-92.
2009: Laura S Burrack; J Wade Harper; Darren E Higgins
Perturbation of vacuolar maturation promotes listeriolysin O-independent vacuolar escape during Listeria monocytogenes infection of human cells.
Cellular microbiology 2009;11(9):1382-98.
2009: Mathew E Sowa; Eric J Bennett; Steven P Gygi; J Wade Harper
Defining the human deubiquitinating enzyme interaction landscape.
Cell 2009;138(2):389-403.
2009: Jennifer M Svendsen; Agata Smogorzewska; Mathew E Sowa; Brenda C. O'Connell; Steven P Gygi; Stephen J Elledge; J Wade Harper
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Cell 2009;138(1):63-77.
2009: Brenda A Schulman; J Wade Harper
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.
Nature reviews. Molecular cell biology 2009;10(5):319-31.
2009: Partha Mitra; Prachi N Ghule; Margaretha van der Deen; Ricardo Medina; Rong-Lin Xie; William F Holmes; Xin Ye; Keiichi I Nakayama; J Wade Harper; Janet L Stein; Gary S Stein; Andre J van Wijnen
CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P.
Journal of cellular physiology 2009;219(2):438-48.
2008: Lai Xu; Mathew E Sowa; Jing Chen; Xue Li; Steven P Gygi; J Wade Harper
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
Molecular biology of the cell 2008;19(12):5059-71.
2008: Gustavo Ayala; Jun Yan; Rile Li; Yi Ding; Timothy C Thompson; Martha P Mims; Teresa G Hayes; Vivian MacDonnell; R Garret Lynch; Anna Frolov; Brian J Miles; Thomas M Wheeler; J Wade Harper; Ming-Jer Tsai; Michael M Ittmann; Dov Kadmon
Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(22):7511-8.
2008: Prachi N Ghule; Zbigniew Dominski; Xiao-Cui Yang; William F Marzluff; Klaus A Becker; J Wade Harper; Jane B Lian; Janet L Stein; Andre J van Wijnen; Gary S Stein
Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16964-9.
2008: Xiaolu L Ang; Daniel P Seeburg; Morgan Sheng; J Wade Harper
Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
The Journal of biological chemistry 2008;283(43):29424-32.
2008: Jianping Jin; Xiaolu L Ang; Xin Ye; Mark Livingstone; J Wade Harper
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.
The Journal of biological chemistry 2008;283(28):19322-8.
2008: Thomas F Westbrook; Guang Hu; Xiaolu L Ang; Peter Mulligan; Natalya N Pavlova; Anthony Liang; Yumei Leng; Rene Maehr; Yang Shi; J Wade Harper; Stephen J Elledge
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.
Nature 2008;452(7185):370-4.
2008: Michael R Schlabach; Ji Luo; Nicole L Solimini; Guang Hu; Qikai Xu; Mamie Z Li; Zhenming Zhao; Agata Smogorzewska; Mathew E Sowa; Xiaolu L Ang; Thomas F Westbrook; Anthony C Liang; Kenneth Chang; Jennifer A Hackett; J Wade Harper; Gregory J Hannon; Stephen J Elledge
Cancer proliferation gene discovery through functional genomics.
Science (New York, N.Y.) 2008;319(5863):620-4.
2008: Eric J Bennett; J Wade Harper
DNA damage: ubiquitin marks the spot.
Nature structural & molecular biology 2008;15(1):20-2.
2007: J Wade Harper; Stephen J Elledge
The DNA damage response: ten years after.
Molecular cell 2007;28(5):739-45.
2007: Prachi N Ghule; Klaus A Becker; J Wade Harper; Jane B Lian; Janet L Stein; Andre J van Wijnen; Gary S Stein
Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells.
Journal of cellular physiology 2007;213(1):9-17.
2007: KyungWon Huh; Xiaobo Zhou; Hiroyuki Hayakawa; Je-Yoel Cho; Towia Libermann; Jianping Jin; J Wade Harper; Karl Munger
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.
Journal of virology 2007;81(18):9737-47.
2007: Jianping Jin; Xue Li; Steven P Gygi; J Wade Harper
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
Nature 2007;447(7148):1135-8.
2007: Frank Stegmeier; Mathew E Sowa; Grzegorz Nalepa; Steven P Gygi; J Wade Harper; Stephen J Elledge
The tumor suppressor CYLD regulates entry into mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8869-74.
2007: Viji M Draviam; Frank Stegmeier; Grzegorz Nalepa; Mathew E Sowa; Jing Chen; Anthony Liang; Gregory J Hannon; Peter K Sorger; J Wade Harper; Stephen J Elledge
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Nature cell biology 2007;9(5):556-64.
2007: Partha Mitra; Ronglin Xie; J Wade Harper; Janet L Stein; Gary S Stein; Andre J van Wijnen
HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription.
Journal of cellular biochemistry 2007;101(1):181-91.
2007: Frank Stegmeier; Michael Rape; Viji M Draviam; Grzegorz Nalepa; Mathew E Sowa; Xiaolu L Ang; E Robert McDonald; Mamie Z Li; Gregory J Hannon; Peter K Sorger; Marc W Kirschner; J Wade Harper; Stephen J Elledge
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Nature 2007;446(7138):876-81.
2007: Bing Hao; Stephanie Oehlmann; Mathew E Sowa; J Wade Harper; Nikola P Pavletich
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
Molecular cell 2007;26(1):131-43.
2007: Brenda C. O'Connell; J Wade Harper
Ubiquitin proteasome system (UPS): what can chromatin do for you?
Current opinion in cell biology 2007;19(2):206-14.
2007: J Wade Harper
Chemical biology: a degrading solution to pollution.
Nature 2007;446(7135):499-500.
2006: Benjamin E Gewurz; J Wade Harper
DNA-damage control: Claspin destruction turns off the checkpoint.
Current biology : CB 2006;16(21):R932-4.
2006: Douglas I Lin; Olena Barbash; K G Suresh Kumar; Jason D. Weber; J Wade Harper; Andres J P Klein-Szanto; Anil K Rustgi; Serge Y Fuchs; J Alan Diehl
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.
Molecular cell 2006;24(3):355-66.
2006: Jianping Jin; Emily E Arias; Jing Chen; J Wade Harper; Johannes C Walter
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
Molecular cell 2006;23(5):709-21.
2006: Grzegorz Nalepa; Mark Rolfe; J Wade Harper
Drug discovery in the ubiquitin-proteasome system.
Nature reviews. Drug discovery 2006;5(7):596-613.
2006: J Wade Harper; Brenda A Schulman
Structural complexity in ubiquitin recognition.
Cell 2006;124(6):1133-6.
2006: Mathew E Sowa; J Wade Harper
From loops to chains: unraveling the mysteries of polyubiquitin chain specificity and processivity.
ACS chemical biology 2006;1(1):20-4.
2006: Aryaman Shalizi; Brice Gaudillière; Zengqiang Yuan; Judith Stegmüller; Takahiro Shirogane; Qingyuan Ge; Yi Tan; Brenda Schulman; J Wade Harper; Azad Bonni
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation.
Science (New York, N.Y.) 2006;311(5763):1012-7.
2006: Tae Ho Lee; Kilian Perrem; J Wade Harper; Kun Ping Lu; Xiao Zhen Zhou
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance.
The Journal of biological chemistry 2006;281(2):759-68.
2005: Martha Simpson-Holley; Robert C Colgrove; Grzegorz Nalepa; J Wade Harper; David M Knipe
Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection.
Journal of virology 2005;79(20):12840-51.
2005: Takahiro Shirogane; Jianping Jin; Xiaolu L Ang; J Wade Harper
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
The Journal of biological chemistry 2005;280(29):26863-72.
2005: Wenyi Wei; Jianping Jin; Suzanne Schlisio; J Wade Harper; William G Kaelin
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.
Cancer cell 2005;8(1):25-33.
2005: Angela Miele; Corey D Braastad; William F Holmes; Partha Mitra; Ricardo Medina; Ronglin Xie; Sayyed K Zaidi; Xin Ye; Yue Wei; J Wade Harper; Andre J van Wijnen; Janet L Stein; Gary S Stein
HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.
Molecular and cellular biology 2005;25(14):6140-53.
2005: Anders Sundqvist; Maria T Bengoechea-Alonso; Xin Ye; Vasyl Lukiyanchuk; Jianping Jin; J Wade Harper; Johan Ericsson
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).
Cell metabolism 2005;1(6):379-91.
2005: Hannah Wingate; Ning Zhang; Mollianne J McGarhen; Isabelle Bedrosian; J Wade Harper; Khandan Keyomarsi
The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27.
The Journal of biological chemistry 2005;280(15):15148-57.
2005: Lori A Passmore; David Barford; J Wade Harper
Purification and assay of the budding yeast anaphase-promoting complex.
Methods in enzymology 2005;398():195-219.
2004: Wentao Deng; Biing Yuan Lin; Ge Jin; Crystal G Wheeler; Tianlin Ma; J Wade Harper; Thomas R Broker; Louise T Chow
Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase.
Journal of virology 2004;78(24):13954-65.
2004: Xin Ye; Grzegorz Nalepa; Markus Welcker; Benedikt M Kessler; Eric Spooner; Jun Qin; Stephen J Elledge; Bruce E Clurman; J Wade Harper
Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.
The Journal of biological chemistry 2004;279(48):50110-9.
2004: Jianping Jin; Timothy Cardozo; Ruth C Lovering; Stephen J Elledge; Michele Pagano; J Wade Harper
Systematic analysis and nomenclature of mammalian F-box proteins.
Genes & development 2004;18(21):2573-80.
2004: Sara B. Cullinan Gladden; John D Gordan; Jianping Jin; J Wade Harper; J Alan Diehl
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
Molecular and cellular biology 2004;24(19):8477-86.
2004: Grzegorz Nalepa; J Wade Harper
Visualization of a highly organized intranuclear network of filaments in living mammalian cells.
Cell motility and the cytoskeleton 2004;59(2):94-108.
2004: Xiaolu L Ang; J Wade Harper
Interwoven ubiquitination oscillators and control of cell cycle transitions.
Science's STKE : signal transduction knowledge environment 2004;2004(242):pe31.
2004: J Wade Harper
Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.
Cell 2004;118(1):2-4.
2004: Markus Welcker; Amir Orian; Jianping Jin; Jonathan E Grim; Jonathan A Grim; J Wade Harper; Robert N Eisenman; Bruce E Clurman
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):9085-90.
2004: Michael T Tetzlaff; Wei Yu; Mamie Li; Pumin Zhang; Milton Finegold; Kathleen A Mahon; J Wade Harper; Robert J Schwartz; Stephen J Elledge
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3338-45.
2004: Maria Rodriguez; Shawn S-C Li; J Wade Harper; Zhou Songyang
An oriented peptide array library (OPAL) strategy to study protein-protein interactions.
The Journal of biological chemistry 2004;279(10):8802-7.
2004: Michael T Tetzlaff; Chang Bai; Milton Finegold; John Wilson; J Wade Harper; Kathleen A Mahon; Stephen J Elledge
Cyclin F disruption compromises placental development and affects normal cell cycle execution.
Molecular and cellular biology 2004;24(6):2487-98.
2004: Wei Wang; Dana Ungermannova; Jianpin Jin; J Wade Harper; Xuedong Liu
Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling.
Oncogene 2004;23(5):1064-75.
2003: Jianping Jin; Takahiro Shirogane; Lai Xu; Grzegorz Nalepa; Jun Qin; Stephen J Elledge; J Wade Harper
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
Genes & development 2003;17(24):3062-74.
2003: Xin Ye; Yue Wei; Grzegorz Nalepa; J Wade Harper
The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.
Molecular and cellular biology 2003;23(23):8586-600.
2003: Partha Mitra; Rong-Lin Xie; Ricardo Medina; Hayk Hovhannisyan; Sayyed K Zaidi; Yue Wei; J Wade Harper; Janet L Stein; Andre J van Wijnen; Gary S Stein
Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase.
Molecular and cellular biology 2003;23(22):8110-23.
2003: Lai Xu; Yue Wei; Jerome Reboul; Philippe Vaglio; Tae-Ho Shin; Marc Vidal; Stephen J Elledge; J Wade Harper
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Nature 2003;425(6955):316-21.
2003: Jianping Jin; J Wade Harper
A license to kill: transcriptional activation and enhanced turnover of Myc by the SCF(kp2) ubiquitin ligase.
Cancer cell 2003;3(6):517-8.
2003: Geng Wu; Guozhou Xu; Brenda A Schulman; Philip Jeffrey; J Wade Harper; Nikola P Pavletich
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
Molecular cell 2003;11(6):1445-56.
2003: Bridget Baumgartner; J Wade Harper
Deafening cycle.
Nature cell biology 2003;5(5):385-7.
2003: Yue Wei; Jianping Jin; J Wade Harper
The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.
Molecular and cellular biology 2003;23(10):3669-80.
2003: Yanchang Wang; Takahiro Shirogane; Dou Liu; J Wade Harper; Stephen J Elledge
Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.
Cell 2003;112(5):697-709.
2003: Lori A Passmore; Elizabeth A McCormack; Shannon W N Au; Angela Paul; Keith R Willison; J Wade Harper; David Barford
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.
The EMBO journal 2003;22(4):786-96.
2002: Guang Yang; Gustavo Ayala; Angelo M DeMarzo; Weihua Tian; Anna Frolov; Thomas M Wheeler; Timothy C Thompson; J Wade Harper
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3419-26.
2002: David M Nelson; Xiaofen Ye; Caitlin Hall; Hidelita Santos; Tianlin Ma; Gary D Kao; Tim J Yen; J Wade Harper; Paul D Adams
Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity.
Molecular and cellular biology 2002;22(21):7459-72.
2002: J Wade Harper; Janet L Burton; Mark J Solomon
The anaphase-promoting complex: it's not just for mitosis any more.
Genes & development 2002;16(17):2179-206.
2002: Grzegorz Nalepa; J Wade Harper
Efp: a ring of independence?
Nature medicine 2002;8(7):661-2.
2002: Jianping Jin; J Wade Harper
RING finger specificity in SCF-driven protein destruction.
Developmental cell 2002;2(6):685-7.
2002: Ning Zheng; Brenda A Schulman; Langzhou Song; Julie J Miller; Philip Jeffrey; Ping Wang; Claire Chu; Deanna M Koepp; Stephen J Elledge; Michele Pagano; Ronald C Conaway; Joan Weliky Conaway; J Wade Harper; Nikola P Pavletich
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature 2002;416(6882):703-9.
2002: Xiaohong Leng; Martin Noble; Peter D Adams; Jun Qin; J Wade Harper
Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.
Molecular and cellular biology 2002;22(7):2242-54.
2002: Shannon W N Au; Xiaohong Leng; J Wade Harper; David Barford
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
Journal of molecular biology 2002;316(4):955-68.
2002: J Wade Harper
A phosphorylation-driven ubiquitination switch for cell-cycle control.
Trends in cell biology 2002;12(3):104-7.
2001: Deanna M Koepp; L K Schaefer; Xin Ye; Khandan Keyomarsi; Claire Chu; J Wade Harper; Stephen J Elledge
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Science (New York, N.Y.) 2001;294(5540):173-7.
2001: J Wade Harper
Protein destruction: adapting roles for Cks proteins.
Current biology : CB 2001;11(11):R431-5.
2001: Xiangcang Ye; C Zhu; J Wade Harper
A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1682-6.
2000: Brenda A Schulman; Andrea C. Carrano; Philip Jeffrey; Z Bowen; Elspeth Kinnucan; Michael S Finnin; Stephen J Elledge; J Wade Harper; Michele Pagano; Nikola P Pavletich
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature 2000;408(6810):381-6.
2000: T Ma; B A Van Tine; Yue Wei; M D Garrett; D Nelson; P D Adams; Jie Wang; Jun Qin; Louise T Chow; J Wade Harper
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
Genes & development 2000;14(18):2298-313.
2000: L Stepanova; Milton Finegold; Francesco DeMayo; E V Schmidt; J Wade Harper
The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues.
Molecular and cellular biology 2000;20(12):4462-73.
2000: L Stepanova; G Yang; Francesco DeMayo; T M Wheeler; Milton Finegold; Timothy C Thompson; J Wade Harper
Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia.
Oncogene 2000;19(18):2186-93.
2000: Biing Yuan Lin; T Ma; JS Liu; SR Kuo; Ge Jin; Thomas R Broker; J Wade Harper; Louise T Chow
HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replication.
The Journal of biological chemistry 2000;275(9):6167-74.
1999: JT Winston; Claire Chu; J Wade Harper
Culprits in the degradation of cyclin E apprehended.
Genes & development 1999;13(21):2751-7.
1999: JT Winston; Deanna M Koepp; C Zhu; Stephen J Elledge; J Wade Harper
A family of mammalian F-box proteins.
Current biology : CB 1999;9(20):1180-2.
1999: Sibel Erdamar; Guang Yang; J Wade Harper; X Lu; Michael W Kattan; Timothy C Thompson; Thomas M Wheeler
Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1999;12(8):751-5.
1999: Katsumi Kitagawa; Dorota Skowyra; Stephen J Elledge; J Wade Harper; Philip Hieter
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.
Molecular cell 1999;4(1):21-33.
1999: Deanna M Koepp; J Wade Harper; Stephen J Elledge
How the cyclin became a cyclin: regulated proteolysis in the cell cycle.
Cell 1999;97(4):431-4.
1999: Dorota Skowyra; Deanna M Koepp; Takumi Kamura; Michael N Conrad; Ronald C Conaway; Joan Weliky Conaway; Stephen J Elledge; J Wade Harper
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Science (New York, N.Y.) 1999;284(5414):662-5.
1999: Takumi Kamura; Deanna M Koepp; Michael N Conrad; Dorota Skowyra; Rodney Moreland; O Iliopoulos; William Stratton Lane; William G Kaelin; Stephen J Elledge; Ronald C Conaway; J Wade Harper; Joan Weliky Conaway
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Science (New York, N.Y.) 1999;284(5414):657-61.
1999: JT Winston; Peter Strack; P Beer-Romero; C Y Chu; Stephen J Elledge; J Wade Harper
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Genes & development 1999;13(3):270-83.
1999: T Ma; Nianxiang Zou; Biing Yuan Lin; Louise T Chow; J Wade Harper
Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):382-7.
1999: Pumin Zhang; C Wong; Dou Liu; Milton Finegold; J Wade Harper; Stephen J Elledge
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Genes & development 1999;13(2):213-24.
1998: Stephen J Elledge; J Wade Harper
The role of protein stability in the cell cycle and cancer.
Biochimica et biophysica acta 1998;1377(2):M61-70.
1998: J Wade Harper; Stephen J Elledge
The role of Cdk7 in CAK function, a retro-retrospective.
Genes & development 1998;12(3):285-9.
1998: L Connell-Crowley; Stephen J Elledge; J Wade Harper
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.
Current biology : CB 1998;8(1):65-8.
1997: Dorota Skowyra; KL Craig; Mike Tyers; Stephen J Elledge; J Wade Harper
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Cell 1997;91(2):209-19.
1997: X Leng; L Connell-Crowley; DW Goodrich; J Wade Harper
S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation.
Current biology : CB 1997;7(9):709-12.
1997: Pumin Zhang; NANETTE LIEGEOIS; C Wong; Milton Finegold; Harry Hou; J C Thompson; A Silverman; J Wade Harper; Ronald A DePinho; Stephen J Elledge
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Nature 1997;387(6629):151-8.
1997: L Connell-Crowley; J Wade Harper; DW Goodrich
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.
Molecular biology of the cell 1997;8(2):287-301.
1997: L Stepanova; X Leng; J Wade Harper
Analysis of mammalian Cdc37, a protein kinase targeting subunit of heat shock protein 90.
Methods in enzymology 1997;283():220-9.
1996: C Bai; P Sen; Kay Hofmann; L Ma; M Goebl; J Wade Harper; Stephen J Elledge
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Cell 1996;86(2):263-74.
1996: L Stepanova; X Leng; S B Parker; J Wade Harper
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
Genes & development 1996;10(12):1491-502.
1996: S Matsuoka; J S Thompson; M C Edwards; J M Bartletta; Paul E Grundy; Linda M Kalikin; J Wade Harper; Stephen J Elledge; Andrew P Feinberg
Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3026-30.
1995: James A Eastham; S J Hall; I Sehgal; Jin Wang; Terry L Timme; Guang Yang; L Connell-Crowley; Stephen J Elledge; W W Zhang; J Wade Harper
In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.
Cancer research 1995;55(22):5151-5.
1995: J Wade Harper; Stephen J Elledge; Khandan Keyomarsi; Brian David Dynlacht; Li-Huei Tsai; P Zhang; S Dobrowolski; C Bai; L Connell-Crowley; Eric C Swindell
Inhibition of cyclin-dependent kinases by p21.
Molecular biology of the cell 1995;6(4):387-400.
1995: S Matsuoka; M C Edwards; C Bai; S Parker; Pumin Zhang; A Baldini; J Wade Harper; Stephen J Elledge
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Genes & development 1995;9(6):650-62.
1995: S B Parker; Gregor Eichele; Pumin Zhang; A Rawls; A T Sands; Allan Bradley; E N Olson; J Wade Harper; Stephen J Elledge
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.
Science (New York, N.Y.) 1995;267(5200):1024-7.
1993: J Wade Harper; Guy R Adami; N Wei; Khandan Keyomarsi; Stephen J Elledge
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Cell 1993;75(4):805-16.
1993: L Connell-Crowley; M J Solomon; N Wei; J Wade Harper
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.
Molecular biology of the cell 1993;4(1):79-92.
1992: Stephen J Elledge; Ronald Richman; Frederick L Hall; Richard Williams; N Lodgson; J Wade Harper
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2907-11.