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Lorraine Harper

Research Profile

Chemicals & Drugs

Disorders

Anatomy

Physiology

Neutrophil Activation

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TOP 3
Colin D Chue; Nicola C Edwards; Lorraine Harper; William E Moody; Richard Steeds; Jonathan N Townend; Nadezhda A Wall; Daniel Zehnder; Charles J Ferro
Cardiovascular Effects of Sevelamer in Stage 3 CKD.
Lorraine Harper
L42. Morbidity in patients with ANCA-associated vasculitis.
Shazia Shabir; Simon Ball; Richard Borrows; Lorraine Harper; Seema Jham; Adnan Sharif
Validity of glycated haemoglobin to diagnose new onset diabetes after transplantation.

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All Publications

2013: Colin D Chue; Nicola C Edwards; Lorraine Harper; William E Moody; Richard Steeds; Jonathan N Townend; Nadezhda A Wall; Daniel Zehnder; Charles J Ferro
Cardiovascular Effects of Sevelamer in Stage 3 CKD.
Journal of the American Society of Nephrology : JASN 2013;24(5):842-52.
2013: Lorraine Harper
L42. Morbidity in patients with ANCA-associated vasculitis.
Presse médicale (Paris, France : 1983) 2013;42(4 Pt 2):612-6.
2013: Shazia Shabir; Simon Ball; Richard Borrows; Lorraine Harper; Seema Jham; Adnan Sharif
Validity of glycated haemoglobin to diagnose new onset diabetes after transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2013;26(3):315-21.
2013: Nadezhda A Wall; Colin D Chue; Nicola C Edwards; Lorraine Harper; Sarah Lauder; Paul Moss; Tanya Pankhurst; Richard Steeds; Jonathan N Townend; Charles J Ferro
Cytomegalovirus seropositivity is associated with increased arterial stiffness in patients with chronic kidney disease.
PloS one 2013;8(2):e55686.
2012: Sahithi J Kuravi; G Ed Rainger; Simon C Satchell; Caroline O S Savage; Anne Bevins; Lorraine Harper; Julie M Williams; Samantha Tull
Neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(12):4331-8.
2012: Nadezhda Wall; Lorraine Harper
Complications of long-term therapy for ANCA-associated systemic vasculitis.
Nature reviews. Nephrology 2012;8(9):523-32.
2012: Allan P Kiprianos; Mark Little; Matthew David Morgan; Paul A Bacon; Lorraine Harper; Stephen P Young
Elevated active secretory sphingomyelinase in antineutrophil cytoplasmic antibody-associated primary systemic vasculitis.
Annals of the rheumatic diseases 2012;71(6):1100-2.
2012: Lorraine Harper; Peter Hoglund; David Jayne; Raashid Luqmani; Matthew David Morgan; Charles Pusey; Niels Rasmussen; Caroline O S Savage; Vladimir Tesar; Phillipe Vanhille; Michael Walsh; Richard Watts; Kerstin Westman; Daniel Blockmans; Annette Bruchfeld; Kirsten de Groot; Luis Felipe Flores-Suarez; Oliver Flossmann
Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up.
Annals of the rheumatic diseases 2012;71(6):955-60.
2012: Samantha Tull; Julie M Williams; Stephen Young; Bahjat Al-Ani; Anne Bevins; Lorraine Harper; Sahithi Jyothsna Kuravi; G Ed Rainger; Simon C Satchell; Caroline O S Savage
PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.
PloS one 2012;7(8):e43916.
2011: N J Holden; Matthew David Morgan; R J Pepper; Alan D Salama; A Challa; J Gordon; Lorraine Harper; Julie Williams; Caroline O S Savage
ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.
Annals of the rheumatic diseases 2011;70(12):2229-33.
2011: H Morris; J Perez; C D Pusey; A D Salama; Caroline O S Savage; S W Smith; R Stockley; S Wieczorek; J Williams; A M Wood; K Herrmann; J U Holle; D A Lomas; A P Maxwell; A J McKnight; E Miranda; Matthew David Morgan; U I Ekeowa; L Guillevin; Lorraine Harper
ANCA-associated vasculitis is linked to carriage of the Z allele of α₁ antitrypsin and its polymers.
Annals of the rheumatic diseases 2011;70(10):1851-6.
2011: Matthew D Morgan; Paul A Moss; Desley A H Neil; Annette Pachnio; Niels Rasmussen; David Roberts; Caroline O S Savage; Ingeborg Bajema; Jusnara Begum; Lorraine Harper
CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality.
Arthritis and rheumatism 2011;63(7):2127-37.
2011: Lorraine Harper; Matthew David Morgan
Plasma exchange for severe ANCA-associated vasculitis?
American journal of kidney diseases : the official journal of the National Kidney Foundation 2011;57(4):532-5.
2011: Neil J Holden; Caroline O S Savage; Michael J Wakelam; Lorraine Harper; Stephen P Young; Julie M Williams
A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1242-52.
2011: Matthew D Morgan; Mark T Drayson; Caroline O S Savage; Lorraine Harper
Addition of infliximab to standard therapy for ANCA-associated vasculitis.
Nephron. Clinical practice 2011;117(2):c89-97.
2010: Joannis Vamvakopoulos; Caroline O Savage; Lorraine Harper
ANCA-associated vasculitides-lessons from the adult literature.
Pediatric nephrology (Berlin, Germany) 2010;25(8):1397-407.
2010: Mark Little; Peter Nightingale; C A Verburgh; Thomas Hauser; Kirsten De Groot; Caroline Savage; David Jayne; Lorraine Harper
Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis.
Annals of the rheumatic diseases 2010;69(6):1036-43.
2010: Lorraine Harper
Recent advances to achieve remission induction in antineutrophil cytoplasmic antibody-associated vasculitis.
Current opinion in rheumatology 2010;22(1):37-42.
2009: Lavanya Kamesh; Joanne M Heward; Julie M Williams; Stephen C L Gough; Konstantia-Maria Chavele; Alan Salama; Charles Pusey; Caroline O S Savage; Lorraine Harper
CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.
Rheumatology (Oxford, England) 2009;48(12):1502-5.
2009: Matthew David Morgan; Jennifer Turnbull; Umut Selamet; Manvir Kaur-Hayer; Peter Nightingale; Charles J Ferro; Caroline O S Savage; Lorraine Harper
Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study.
Arthritis and rheumatism 2009;60(11):3493-500.
2009: Jennifer Turnbull; Lorraine Harper
Adverse effects of therapy for ANCA-associated vasculitis.
Best practice & research. Clinical rheumatology 2009;23(3):391-401.
2009: Lalit Pallan; Caroline O Savage; Lorraine Harper
ANCA-associated vasculitis: from bench research to novel treatments.
Nature reviews. Nephrology 2009;5(5):278-86.
2009: Tanya Pankhurst; Julia Lepenies; Peter Nightingale; Alexander J Howie; Dwomoa Adu; Lorraine Harper
Vasculitic IgA nephropathy: prognosis and outcome.
Nephron. Clinical practice 2009;112(1):c16-24.
2007: Frauke Weidanz; Clara J Day; Peter Hewins; Caroline O S Savage; Lorraine Harper
Recurrences and infections during continuous immunosuppressive therapy after beginning dialysis in ANCA-associated vasculitis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2007;50(1):36-46.
2007: Lavanya Kamesh; Joanne M Heward; Julie Williams; S C L Gough; Caroline O S Savage; Lorraine Harper
Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis.
Rheumatology (Oxford, England) 2007;46(7):1076-8.
2007: Manuela Fanciulli; Penny J Norsworthy; Enrico Petretto; Rong Dong; Lorraine Harper; Lavanya Kamesh; Joanne M Heward; S C L Gough; Adam de Smith; Alexandra I F Blakemore; philippe froguel; Catherine J Owen; Simon H S Pearce; Luis Teixeira; Loic Guillevin; Deborah S Cunninghame Graham; Charles D Pusey; H Terence Cook; Timothy J Vyse; Timothy J Aitman
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.
Nature genetics 2007;39(6):721-3.
2007: Umut Selamet; Yuriy B Kovaliv; Caroline O S Savage; Lorraine Harper
ANCA-associated vasculitis: new options beyond steroids and cytotoxic drugs.
Expert opinion on investigational drugs 2007;16(5):689-703.
2006: Tahmina Rahman; Lorraine Harper
Plasmapheresis in nephrology: an update.
Current opinion in nephrology and hypertension 2006;15(6):603-9.
2006: Matthew David Morgan; Lorraine Harper; Julie Williams; Caroline Savage
Anti-neutrophil cytoplasm-associated glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2006;17(5):1224-34.
2006: Lorraine Harper
ANCA-associated vasculitis: is there a role for neutrophil apoptosis in autoimmunity?
Expert review of clinical immunology 2006;2(2):237-44.
2006: David R Thickett; A G Richter; N Nathani; Gavin D Perkins; Lorraine Harper
Pulmonary manifestations of anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis.
Rheumatology (Oxford, England) 2006;45(3):261-8.
2006: Peter Hewins; Matthew David Morgan; N Holden; Desley A H Neil; Julie Williams; Caroline O S Savage; Lorraine Harper
IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis.
Kidney international 2006;69(3):605-15.
2005: Julie U Holle; Julie Williams; Lorraine Harper; Caroline O S Savage; C Mark Taylor
Effect of verocytotoxins (Shiga-like toxins) on human neutrophils in vitro.
Pediatric nephrology (Berlin, Germany) 2005;20(9):1237-44.
2005: Julie Williams; R Colman; C J Brookes; Caroline O S Savage; Lorraine Harper
Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis.
Rheumatology (Oxford, England) 2005;44(7):879-84.
2005: C Newall; S Schinke; Caroline O S Savage; S Hill; Lorraine Harper
Impairment of lung function, health status and functional capacity in patients with ANCA-associated vasculitis.
Rheumatology (Oxford, England) 2005;44(5):623-8.
2005: Matthew David Morgan; Lorraine Harper; X Lu; G Nash; Julie Williams; Caroline O S Savage
Can neutrophils be manipulated in vivo?
Rheumatology (Oxford, England) 2005;44(5):597-601.
2005: Lorraine Harper; Caroline O S Savage
ANCA-associated renal vasculitis at the end of the twentieth century--a disease of older patients.
Rheumatology (Oxford, England) 2005;44(4):495-501.
2004: Tanya Pankhurst; Caroline O S Savage; Caroline Gordon; Lorraine Harper
Malignancy is increased in ANCA-associated vasculitis.
Rheumatology (Oxford, England) 2004;43(12):1532-5.
2004: Lorraine Harper; L Chin; Jacqueline Daykin; Amit Allahabadia; Joanne M Heward; S C L Gough; Caroline O S Savage; Jayne A Franklyn
Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' disease.
Clinical endocrinology 2004;60(6):671-5.
2004: Lorraine Harper; Julie Williams; Caroline O S Savage
The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis.
Biochemical Society transactions 2004;32(Pt3):502-6.
2003: Abigail R Clayton; Rebecca L Prue; Lorraine Harper; Mark T Drayson; Caroline O S Savage
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Arthritis and rheumatism 2003;48(8):2362-74.
2002: Mark Holland; K Takada; T Okumoto; N Takahashi; K Kato; Dwomoa Adu; Anne Ben-Smith; Lorraine Harper; Caroline O S Savage; Roy Jefferis
Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis.
Clinical and experimental immunology 2002;129(1):183-90.
2002: Lavanya Kamesh; Lorraine Harper; Caroline O S Savage
ANCA-positive vasculitis.
Journal of the American Society of Nephrology : JASN 2002;13(7):1953-60.
2002: Caroline O S Savage; Lorraine Harper; Mark Holland
New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis.
Current opinion in rheumatology 2002;14(1):15-22.
2001: Lorraine Harper; Caroline O S Savage
Leukocyte-endothelial interactions in antineutrophil cytoplasmic antibody-associated systemic vasculitis.
Rheumatic diseases clinics of North America 2001;27(4):887-903.
2001: Lorraine Harper; Paul Cockwell; Dwomoa Adu; Caroline O S Savage
Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
Kidney international 2001;59(5):1729-38.
2001: Lorraine Harper; DJ Radford; T Plant; Mark T Drayson; Dwomoa Adu; Caroline O S Savage
IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients.
Arthritis and rheumatism 2001;44(4):921-30.
2000: Lorraine Harper; Maria Alice S Ferreira; Alexander J Howie; Caroline O S Savage; Nick Richards; Jonathan Michael; Dwomoa Adu
Treatment of vasculitic IgA nephropathy.
Journal of nephrology 2000;13(5):360-6.
2000: Lorraine Harper; Y Ren; J Savill; Dwomoa Adu; Caroline O S Savage
Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages.
The American journal of pathology 2000;157(1):211-20.
2000: Caroline O S Savage; Lorraine Harper; Paul Cockwell; Dwomoa Adu; Alexander J Howie
ABC of arterial and vascular disease: vasculitis.
BMJ (Clinical research ed.) 2000;320(7245):1325-8.
2000: Lorraine Harper; Caroline O S Savage
Pathogenesis of ANCA-associated systemic vasculitis.
The Journal of pathology 2000;190(3):349-59.
1999: Lorraine Harper; Caroline O S Savage
Treatment of IgA nephropathy.
Lancet 1999;353(9156):860-2.
1999: Lorraine Harper; Caroline O S Savage
Mechanisms of endothelial injury in systemic vasculitis.
Advances in nephrology from the Necker Hospital 1999;29():1-15.
1998: I Rajman; Lorraine Harper; D McPake; Martin J Kendall; David C Wheeler
Low-density lipoprotein subfraction profiles in chronic renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(9):2281-7.
1998: Lorraine Harper; Paul Cockwell; Caroline O S Savage
Case of propylthiouracil-induced ANCA associated small vessel vasculitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(2):455-8.
1997: Lorraine Harper; Dwomoa Adu
Glomerulonephritis and non-Hodgkin lymphoma.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(7):1520-5.
1997: Lorraine Harper; Paul Cockwell; Alexander J Howie; Jonathan Michael; Nick Richards; Caroline O S Savage; David C Wheeler; P A Bacon; Dwomoa Adu
Focal segmental necrotizing glomerulonephritis in rheumatoid arthritis.
QJM : monthly journal of the Association of Physicians 1997;90(2):125-32.
1996: C J Lote; Lorraine Harper; Caroline O S Savage
Mechanisms of acute renal failure.
British journal of anaesthesia 1996;77(1):82-9.