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Karen Harrington-Brock

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L Scott Clark; Karen Harrington-Brock; Jianyong Wang; Linda M Sargent; David Lowry; Steve H Reynolds; Martha M Moore
Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells.
Karen Harrington-Brock; Deborah D Collard; Tao Chen
Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Andrew D Kligerman; Carolyn L Doerr; Alan H Tennant; Karen Harrington-Brock; James W Allen; Ernest Winkfield; Patricia Poorman-Allen; Bijit Kundu; Kunihiro Funasaka; Barbara C Roop; Marc J Mass; David M DeMarini
Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations.

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All Publications

2004: L Scott Clark; Karen Harrington-Brock; Jianyong Wang; Linda M Sargent; David Lowry; Steve H Reynolds; Martha M Moore
Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells.
Mutagenesis 2004;19(4):263-8.
2003: Karen Harrington-Brock; Deborah D Collard; Tao Chen
Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Mutation research 2003;537(1):21-8.
2003: Andrew D Kligerman; Carolyn L Doerr; Alan H Tennant; Karen Harrington-Brock; James W Allen; Ernest Winkfield; Patricia Poorman-Allen; Bijit Kundu; Kunihiro Funasaka; Barbara C Roop; Marc J Mass; David M DeMarini
Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations.
Environmental and molecular mutagenesis 2003;42(3):192-205.
2002: Tao Chen; Karen Harrington-Brock; Martha M Moore
Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.
Mutagenesis 2002;17(2):105-9.
2002: Martha M Moore; Masamitsu Honma; Julie Clements; Karen Harrington-Brock; Takumi Awogi; George Bolcsfoldi; Maria Cifone; Deborah D Collard; Michael Fellows; Kathryn Flanders; B Bhaskar Gollapudi; Peter Jenkinson; Paul Kirby; Stephan Kirchner; Joann Kraycer; Stephen McEnaney; Wolfgang Muster; Brian Myhr; Michael O'Donovan; Jo Oliver; Marie-Claude Ouldelhkim; Kamala Pant; Robert Preston; Colin Riach; Richard San; Hiroyasu Shimada; Leon F Stankowski
Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000.
Environmental and molecular mutagenesis 2002;40(4):292-9.
2002: Tao Chen; Karen Harrington-Brock; Martha M Moore
Mutant frequency and mutational spectra in the Tk and Hprt genes of N-ethyl-N-nitrosourea-treated mouse lymphoma cellsdagger.
Environmental and molecular mutagenesis 2002;39(4):296-305.
2000: Martha M Moore; Masamitsu Honma; Julie Clements; Takumi Awogi; George Bolcsfoldi; J Cole; B Bhaskar Gollapudi; Karen Harrington-Brock; A Mitchell; Wolfgang Muster; Brian Myhr; Michael O'Donovan; Marie-Claude Ouldelhkim; Richard San; Hiroyasu Shimada; Leon F Stankowski
Mouse lymphoma thymidine kinase locus gene mutation assay: International Workshop on Genotoxicity Test Procedures Workgroup Report.
Environmental and molecular mutagenesis 2000;35(3):185-90.
1999: Karen Harrington-Brock; M Cabrera; Deborah D Collard; Carolyn L Doerr; R McConnell; Martha M Moore; H Sandoval; James C Fuscoe
Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: a pilot study.
Mutation research 1999;431(2):247-57.
1999: Martha M Moore; Karen Harrington-Brock; J Cole
Issues for conducting the microtiter version of the mouse lymphoma thymidine kinase (tk) assay and a critical review of data generated in a collaborative trial using the microtiter method.
Mutagenesis 1999;14(3):271-81.
1999: Martha M Moore; Deborah D Collard; Karen Harrington-Brock
Failure to adequately use positive control data leads to poor quality mouse lymphoma data assessments.
Mutagenesis 1999;14(3):261-3.
1998: L Scott Clark; D W Hart; P J Vojta; Karen Harrington-Brock; J C Barrett; Martha M Moore; Kenneth Tindall
Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Mutagenesis 1998;13(5):427-34.
1998: Karen Harrington-Brock; Carolyn L Doerr; Martha M Moore
Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells.
Mutation research 1998;413(3):265-76.
1998: William L Bigbee; James C Fuscoe; Stephen G Grant; Irene M Jones; A E Gorvad; Karen Harrington-Brock; C L Strout; Cynthia B Thomas; Martha M Moore
Human in vivo somatic mutation measured at two loci: individuals with stably elevated background erythrocyte glycophorin A (gpa) variant frequencies exhibit normal T-lymphocyte hprt mutant frequencies.
Mutation research 1998;397(2):119-36.
1997: Martha M Moore; Karen Harrington-Brock; Carolyn L Doerr
Relative genotoxic potency of arsenic and its methylated metabolites.
Mutation research 1997;386(3):279-90.
1995: Karen Harrington-Brock; Carolyn L Doerr; Martha M Moore
Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/(-)-3.7.2C mouse lymphoma cells.
Mutation research 1995;348(3):105-10.
1994: James C Fuscoe; L J Zimmerman; Karen Harrington-Brock; Martha M Moore
Deletion mutations in the hprt gene of T-lymphocytes as a biomarker for genomic rearrangements important in human cancers.
Carcinogenesis 1994;15(7):1463-6.
1994: James C Fuscoe; L J Zimmerman; Karen Harrington-Brock; Martha M Moore
Multiplex PCR analysis of in vivo-arising deletion mutations in the hprt gene of human T-lymphocytes.
Environmental and molecular mutagenesis 1994;23(2):89-95.
1993: Martha M Moore; Karen Harrington-Brock; L J Zimmerman; L P Burnette; T W Smith; R B Everson; J Patrick O'Neill; James C Fuscoe
Quantification and molecular characterization of hprt mutants of human T-lymphocytes.
Environmental health perspectives 1993;101 Suppl 3():219-24.
1993: Kerry L Dearfield; Karen Harrington-Brock; Carolyn L Doerr; L Parker; Martha M Moore
Genotoxicity of three pyridine compounds to L5178Y mouse lymphoma cells.
Mutation research 1993;301(1):57-63.
1992: James C Fuscoe; L J Zimmerman; Karen Harrington-Brock; Martha M Moore
Large deletions are tolerated at the hprt locus of in vivo derived human T-lymphocytes.
Mutation research 1992;283(4):255-62.
1992: James C Fuscoe; L J Zimmerman; Karen Harrington-Brock; L Burnette; Martha M Moore; Janice A Nicklas; J Patrick O'Neill; Richard J Albertini
V(D)J recombinase-mediated deletion of the hprt gene in T-lymphocytes from adult humans.
Mutation research 1992;283(1):13-20.
1991: Kerry L Dearfield; Karen Harrington-Brock; Carolyn L Doerr; J R Rabinowitz; Martha M Moore
Genotoxicity in mouse lymphoma cells of chemicals capable of Michael addition.
Mutagenesis 1991;6(6):519-25.
1991: Martha M Moore; Karen Harrington-Brock; L Parker; Carolyn L Doerr; John Hozier
Genotoxicity of 2-amino-6-N-hydroxyadenine (AHA) to mouse lymphoma and CHO cells.
Mutation research 1991;253(1):63-71.
1991: Karen Harrington-Brock; L Parker; Carolyn L Doerr; M C Cimino; Martha M Moore
Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay.
Mutagenesis 1991;6(1):35-46.
1991: Martha M Moore; L Parker; J Huston; Karen Harrington-Brock; Kerry L Dearfield
Comparison of mutagenicity results for nine compounds evaluated at the hgprt locus in the standard and suspension CHO assays.
Mutagenesis 1991;6(1):77-85.
1990: L C Backer; J W Allen; Karen Harrington-Brock; J A Campbell; David M DeMarini; Carolyn L Doerr; D R Howard; Andrew D Kligerman; Martha M Moore
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
Mutagenesis 1990;5(6):541-7.
1989: Martha M Moore; Karen Harrington-Brock; Carolyn L Doerr; Kerry L Dearfield
Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci.
Mutagenesis 1989;4(5):394-403.
1989: Kerry L Dearfield; C S Millis; Karen Harrington-Brock; Carolyn L Doerr; Martha M Moore
Analysis of the genotoxicity of nine acrylate/methacrylate compounds in L5178Y mouse lymphoma cells.
Mutagenesis 1989;4(5):381-93.
1989: Carolyn L Doerr; Karen Harrington-Brock; Martha M Moore
Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells.
Mutation research 1989;222(3):191-203.