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Lea Harrington

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David C F Sealey; Aleksandar D Kostic; Catherine LeBel; Fiona Pryde; Lea Harrington
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
Bryan E Snow; Maria Mateyak; Jana Paderova; Andrew Wakeham; Caterina Iorio; Virginia Zakian; Jeremy Squire; Lea Harrington
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo.
Christian E Isaac; Sarah M Francis; Alison L Martens; Lisa M Julian; Laurie A Seifried; Natalie Erdmann; Ulrich K Binné; Lea Harrington; Piotr Sicinski; Nathalie G Bérubé; Nicholas J Dyson; Frederick A Dick
The retinoblastoma protein regulates pericentric heterochromatin.

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All Publications

2011: David C F Sealey; Aleksandar D Kostic; Catherine LeBel; Fiona Pryde; Lea Harrington
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
BMC molecular biology 2011;12():45.
2007: Bryan E Snow; Maria Mateyak; Jana Paderova; Andrew Wakeham; Caterina Iorio; Virginia Zakian; Jeremy Squire; Lea Harrington
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo.
Molecular and cellular biology 2007;27(3):1017-26.
2006: Christian E Isaac; Sarah M Francis; Alison L Martens; Lisa M Julian; Laurie A Seifried; Natalie Erdmann; Ulrich K Binné; Lea Harrington; Piotr Sicinski; Nathalie G Bérubé; Nicholas J Dyson; Frederick A Dick
The retinoblastoma protein regulates pericentric heterochromatin.
Molecular and cellular biology 2006;26(9):3659-71.
2006: Mark Ungrin; Lea Harrington
Strict control of telomerase activation using Cre-mediated inversion.
BMC biotechnology 2006;6():10.
2005: J C Y Wang; Jennifer K Warner; Natalie Erdmann; PM Lansdorp; Lea Harrington; John E Dick
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14398-403.
2005: Jennifer K Warner; J C Y Wang; K Takenaka; S Doulatov; Joby L McKenzie; Lea Harrington; John E Dick
Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.
Leukemia 2005;19(10):1794-805.
2005: Lea Harrington
Making the most of a little: dosage effects in eukaryotic telomere length maintenance.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2005;13(5):493-504.
2005: Michael J Poderycki; Leonard H Rome; Lea Harrington; Valerie A Kickhoefer
The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle.
Nucleic acids research 2005;33(3):893-902.
2004: Yeshi Mikyas; Miriam Makabi; Sujna Raval-Fernandes; Lea Harrington; Valerie A Kickhoefer; Leonard H Rome; Phoebe L Stewart
Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.
Journal of molecular biology 2004;344(1):91-105.
2004: Lea Harrington
Does the reservoir for self-renewal stem from the ends?
Oncogene 2004;23(43):7283-9.
2004: Rena Oulton; Lea Harrington
A human telomerase-associated nuclease.
Molecular biology of the cell 2004;15(7):3244-56.
2004: Dawn Edmonds; Bobby-Joe Breitkreutz; Lea Harrington
A genome-wide telomere screen in yeast: the long and short of it all.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9515-6.
2004: Yie Liu; Bryan E Snow; Valerie A Kickhoefer; Natalie Erdmann; Wen Zhou; Andrew Wakeham; Marla Gomez; Leonard H Rome; Lea Harrington
Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.
Molecular and cellular biology 2004;24(12):5314-23.
2004: Natalie Erdmann; Yie Liu; Lea Harrington
Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6080-5.
2004: Lea Harrington
Those dam-aged telomeres!
Current opinion in genetics & development 2004;14(1):22-8.
2003: Lea Harrington
Biochemical aspects of telomerase function.
Cancer letters 2003;194(2):139-54.
2003: Bryan E Snow; Natalie Erdmann; Jennifer Cruickshank; Hartt Goldman; R Montgomery Gill; Murray O Robinson; Lea Harrington
Functional conservation of the telomerase protein Est1p in humans.
Current biology : CB 2003;13(8):698-704.
2002: Yie Liu; Hue Kha; Mark Ungrin; Murray O Robinson; Lea Harrington
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3597-602.
2002: Lea Harrington; Murray O Robinson
Telomere dysfunction: multiple paths to the same end.
Oncogene 2002;21(4):592-7.
2001: TL Beattie; Wenjing Zhou; Murray O Robinson; Lea Harrington
Functional multimerization of the human telomerase reverse transcriptase.
Molecular and cellular biology 2001;21(18):6151-60.
2001: Valerie A Kickhoefer; Y Liu; LB Kong; Bryan E Snow; Phoebe L Stewart; Lea Harrington; Leonard H Rome
The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.
The Journal of cell biology 2001;152(1):157-64.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; D Yeung; Natalie Erdmann; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.
Current biology : CB 2000;10(22):1459-62.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; G Baerlocher; Valerie A Kickhoefer; D Yeung; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
Molecular and cellular biology 2000;20(21):8178-84.
2000: TL Beattie; Wenjing Zhou; Murray O Robinson; Lea Harrington
Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding.
Molecular biology of the cell 2000;11(10):3329-40.
2000: Rena Oulton; Lea Harrington
Telomeres, telomerase, and cancer: life on the edge of genomic stability.
Current opinion in oncology 2000;12(1):74-81.
1999: Valerie A Kickhoefer; Andrew G Stephen; Lea Harrington; Murray O Robinson; Leonard H Rome
Vaults and telomerase share a common subunit, TEP1.
The Journal of biological chemistry 1999;274(46):32712-7.
1999: X Zhang; V Mar; Wenjing Zhou; Lea Harrington; Murray O Robinson
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells.
Genes & development 1999;13(18):2388-99.
1998: TL Beattie; Wenjing Zhou; Murray O Robinson; Lea Harrington
Reconstitution of human telomerase activity in vitro.
Current biology : CB 1998;8(3):177-80.
1997: Lea Harrington; Wenjing Zhou; T McPhail; Rena Oulton; D S Yeung; V Mar; M B Bass; Murray O Robinson
Human telomerase contains evolutionarily conserved catalytic and structural subunits.
Genes & development 1997;11(23):3109-15.
1997: Lea Harrington; T McPhail; V Mar; Wenjing Zhou; Rena Oulton; M B Bass; I Arruda; Murray O Robinson
A mammalian telomerase-associated protein.
Science (New York, N.Y.) 1997;275(5302):973-7.