FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Constance Harris

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Genes, ras

Concepts & Ideas

Co-author Network

Publications

TOP 3
Constance M Harris; Ivan D Kozekov; Carmelo J Rizzo; Donald F Stec; Plamen P Christov; Thomas M Harris
Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzene.
Kyle L Brown; Markus Voehler; Shane M Magee; Constance M Harris; Thomas M Harris; Michael P Stone
Structural perturbations induced by the alpha-anomer of the aflatoxin B(1) formamidopyrimidine adduct in duplex and single-strand DNA.
Hai Huang; Patricia A Dooley; Constance M Harris; Thomas M Harris; Michael P Stone
Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Constance Harris (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Constance M Harris; Ivan D Kozekov; Carmelo J Rizzo; Donald F Stec; Plamen P Christov; Thomas M Harris
Deoxyguanosine forms a bis-adduct with E,E-muconaldehyde, an oxidative metabolite of benzene: implications for the carcinogenicity of benzene.
Chemical research in toxicology 2011;24(11):1944-56.
2009: Kyle L Brown; Markus Voehler; Shane M Magee; Constance M Harris; Thomas M Harris; Michael P Stone
Structural perturbations induced by the alpha-anomer of the aflatoxin B(1) formamidopyrimidine adduct in duplex and single-strand DNA.
Journal of the American Chemical Society 2009;131(44):16096-107.
2009: Hai Huang; Patricia A Dooley; Constance M Harris; Thomas M Harris; Michael P Stone
Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.
Chemical research in toxicology 2009;22(11):1810-6.
2007: Wen Xu; W Keither Merritt; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.
Chemical research in toxicology 2007;20(2):187-98.
2006: Kyle L Brown; James Z Deng; Rajkumar S Iyer; Lalitha G Iyer; Markus Voehler; Michael P Stone; Constance M Harris; Thomas Harris
Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.
Journal of the American Chemical Society 2006;128(47):15188-99.
2005: Manorama Kanuri; Lubomir V Nechev; Sarah E Kiehna; Pamela J Tamura; Constance M Harris; Thomas Harris; R Stephen Lloyd
Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks.
DNA repair 2005;4(12):1374-80.
2005: W Keither Merritt; Lubomir V Nechev; Tandace A Scholdberg; Stephen M Dean; Sarah E Kiehna; Johanna C Chang; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.
Biochemistry 2005;44(30):10081-92.
2005: W Keither Merritt; Agnieszka Kowalczyk; Tandace A Scholdberg; Stephen M Dean; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adducts: a structural perspective.
Chemical research in toxicology 2005;18(7):1098-107.
2005: Tandace A Scholdberg; W Keither Merritt; Stephen M Dean; Agnieska Kowalcyzk; Constance M Harris; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.
Biochemistry 2005;44(9):3327-37.
2005: Tandace A Scholdberg; Lubomir V Nechev; W Keither Merritt; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction.
Chemical research in toxicology 2005;18(2):145-53.
2004: W Keither Merritt; Tandace A Scholdberg; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Stereospecific structural perturbations arising from adenine N(6) butadiene triol adducts in duplex DNA.
Chemical research in toxicology 2004;17(8):1007-19.
2004: Tandace A Scholdberg; Lubomir V Nechev; W Keither Merritt; Thomas Harris; Constance M Harris; R Stephen Lloyd; Michael P Stone
Structure of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA adduct of butadiene diol epoxide.
Chemical research in toxicology 2004;17(6):717-30.
2003: Hye-Young H Kim; Amanda S Wilkinson; Constance M Harris; Thomas Harris; Michael P Stone
Minor groove orientation for the (1S,2R,3S,4R)-N2- [1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyguanosyl adduct in the N-ras codon 12 sequence.
Biochemistry 2003;42(8):2328-38.
2003: Patricia A Dooley; Mingzhou Zhang; Gregory A Korbel; Lubomir V Nechev; Constance M Harris; Michael P Stone; Thomas Harris
NMR determination of the conformation of a trimethylene interstrand cross-link in an oligodeoxynucleotide duplex containing a 5'-d(GpC) motif.
Journal of the American Chemical Society 2003;125(1):62-72.
2003: Ivan D Kozekov; Lubomir V Nechev; M Scott Moseley; Constance M Harris; Carmelo J Rizzo; Michael P Stone; Thomas Harris
DNA interchain cross-links formed by acrolein and crotonaldehyde.
Journal of the American Chemical Society 2003;125(1):50-61.
2002: Manorama Kanuri; Lubomir V Nechev; Pamela J Tamura; Constance M Harris; Thomas Harris; R Stephen Lloyd
Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells.
Chemical research in toxicology 2002;15(12):1572-80.
2002: Manorama Kanuri; Irina G Minko; Lubomir V Nechev; Thomas Harris; Constance M Harris; R Stephen Lloyd
Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells.
The Journal of biological chemistry 2002;277(21):18257-65.
2002: Agnieszka Kowalczyk; J Russ Carmical; Yue Zou; Bennett Van Houten; R Stephen Lloyd; Constance M Harris; Thomas Harris
Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines.
Biochemistry 2002;41(9):3109-18.
2001: Lubomir V Nechev; Ivan D Kozekov; Constance M Harris; Thomas Harris
Stereospecific synthesis of oligonucleotides containing crotonaldehyde adducts of deoxyguanosine.
Chemical research in toxicology 2001;14(11):1506-12.
2001: Ivan D Kozekov; Lubomir V Nechev; A Sanchez; Constance M Harris; R Stephen Lloyd; Thomas Harris
Interchain cross-linking of DNA mediated by the principal adduct of acrolein.
Chemical research in toxicology 2001;14(11):1482-5.
2001: Hye-Young H Kim; M Cooper; Lubomir V Nechev; Constance M Harris; Thomas Harris
Synthesis and characterization of nucleosides and oligonucleotides with a benzo[a]pyren-6-ylmethyl adduct at adenine N6 or guanine N2.
Chemical research in toxicology 2001;14(9):1306-14.
2001: C Hennard; JI Finneman; Constance M Harris; Thomas Harris; Michael P Stone
The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.
Biochemistry 2001;40(33):9780-91.
2001: Z Li; Pamela J Tamura; Amanda S Wilkinson; Constance M Harris; Thomas Harris; Michael P Stone
Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects.
Biochemistry 2001;40(23):6743-55.
2001: Agnieszka Kowalczyk; Constance M Harris; Thomas Harris
Synthesis and characterization of oligodeoxynucleotides containing an N1 beta-hydroxyalkyl adduct of 2'-deoxyinosine.
Chemical research in toxicology 2001;14(6):746-53.
2001: Thomas Harris; Constance M Harris
Synthesis of N2-substituted deoxyguanosine nucleosides from 2-fluoro-6-O-(trimethylsilylethyl)-2'-deoxyinosine.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 1():Unit 1.3.
2001: Lubomir V Nechev; M Zhang; D Tsarouhtsis; Pamela J Tamura; Amanda S Wilkinson; Constance M Harris; Thomas Harris
Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2).
Chemical research in toxicology 2001;14(4):379-88.
2001: Laurie A VanderVeen; Muhammed F Hashim; Lubomir V Nechev; Thomas Harris; Constance M Harris; Lawrence J Marnett
Evaluation of the mutagenic potential of the principal DNA adduct of acrolein.
The Journal of biological chemistry 2001;276(12):9066-70.
2001: P A Dooley; D Tsarouhtsis; G A Korbel; Lubomir V Nechev; J Shearer; IS Zegar; Constance M Harris; Michael P Stone; Thomas Harris
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-link.
Journal of the American Chemical Society 2001;123(8):1730-9.
2001: Manorama Kanuri; JI Finneman; Constance M Harris; Thomas Harris; R Stephen Lloyd
Efficient nonmutagenic replication bypass of DNAs containing beta-adducts of styrene oxide at adenine N(6).
Environmental and molecular mutagenesis 2001;38(4):357-60.
2001: D A Rodriguez; Agnieszka Kowalczyk; Jonathan B Ward; Constance M Harris; Thomas Harris; R Stephen Lloyd
Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts.
Environmental and molecular mutagenesis 2001;38(4):292-6.
2000: Hye-Young H Kim; JI Finneman; Constance M Harris; Thomas Harris
Studies of the mechanisms of adduction of 2'-deoxyadenosine with styrene oxide and polycyclic aromatic hydrocarbon dihydrodiol epoxides.
Chemical research in toxicology 2000;13(7):625-37.
2000: J Russ Carmical; Agnieszka Kowalczyk; Yue Zou; Bennett Van Houten; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis.
The Journal of biological chemistry 2000;275(26):19482-9.
2000: Lubomir V Nechev; Constance M Harris; Thomas Harris
Synthesis of nucleosides and oligonucleotides containing adducts of acrolein and vinyl chloride.
Chemical research in toxicology 2000;13(5):421-9.
2000: M F Simeonov; Pamela J Tamura; Amanda S Wilkinson; Constance M Harris; Thomas Harris; Michael P Stone
Sequence- and stereospecific conformational rearrangement of styrene oxide adducts located at A x C mismatched base pairs.
Biochemistry 2000;39(5):924-37.
2000: P T Le; Constance M Harris; Thomas Harris; Michael P Stone
Altered electrophoretic migration of polycyclic aromatic hydrocarbon and styrene oxide adducts at adenine N(6) correlates with adduct-induced structural disorder.
Chemical research in toxicology 2000;13(2):63-71.
2000: J Russ Carmical; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Mutagenic potential of adenine N(6) adducts of monoepoxide and diolepoxide derivatives of butadiene.
Environmental and molecular mutagenesis 2000;35(1):48-56.
2000: J Russ Carmical; M Zhang; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide.
Chemical research in toxicology 2000;13(1):18-25.
1999: Z Li; Hye-Young H Kim; Pamela J Tamura; Constance M Harris; Thomas Harris; Michael P Stone
Intercalation of the (1S,2R,3S,4R)-N6-[1-(1,2,3,4-tetrahydro-2,3, 4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(49):16045-57.
1999: Z Li; Hye-Young H Kim; Pamela J Tamura; Constance M Harris; Thomas Harris; Michael P Stone
Role of a polycyclic aromatic hydrocarbon bay region ring in modulating DNA adduct structure: the non-bay region (8S,9R,10S, 11R)-N(6)-[11-(8,9,10,11-tetrahydro-8,9, 10-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in codon 61 of the human N-ras protooncogene.
Biochemistry 1999;38(45):14820-32.
1999: V Gurvich; Hye-Young H Kim; R P Hodge; Constance M Harris; Thomas Harris
Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides.
Nucleosides & nucleotides 1999;18(10):2327-33.
1999: S L Painter; IS Zegar; Pamela J Tamura; S Bluhm; Constance M Harris; Thomas Harris; Michael P Stone
Influence of the R(61,2)- and S(61,2)-alpha-(N6-adenyl)styrene oxide adducts on the A.C mismatched base pair in an oligodeoxynucleotide containing the human N-ras codon 61.
Biochemistry 1999;38(27):8635-46.
1999: Z Li; H Mao; Hye-Young H Kim; Pamela J Tamura; Constance M Harris; Thomas Harris; Michael P Stone
Intercalation of the (-)-(1R,2S,3R, 4S)-N6-[1-benz[a]anthracenyl]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(10):2969-81.
1998: IS Zegar; P Chary; R J Jabil; Pamela J Tamura; T N Johansen; R Stephen Lloyd; Constance M Harris; Thomas Harris; Michael P Stone
Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.
Biochemistry 1998;37(47):16516-28.
1998: F R Setayesh; B L DeCorte; P Horton; Constance M Harris; Thomas Harris; Michael P Stone
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12: minor groove structures of the R(12,1)- and S(12,1)-alpha-(N2-guanyl) stereoisomers determined by 1H nuclear magnetic resonance.
Chemical research in toxicology 1998;11(7):766-77.
1997: A G McNees; M O'Donnell; P H Horton; H Y Kim; S J Kim; Constance M Harris; Thomas Harris; R Stephen Lloyd
Lack of correlation between in vitro and in vivo replication of precisely defined benz-a-anthracene adducted DNAs.
The Journal of biological chemistry 1997;272(52):33211-9.
1997: P Chary; Constance M Harris; Thomas Harris; R Stephen Lloyd
Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates.
The Journal of biological chemistry 1997;272(9):5805-13.
1996: G J Latham; A G McNees; B De Corte; Constance M Harris; Thomas Harris; M O'Donnell; R Stephen Lloyd
Comparison of the efficiency of synthesis past single bulky DNA adducts in vivo and in vitro by the polymerase III holoenzyme.
Chemical research in toxicology 1996;9(7):1167-75.
1996: B Feng; M Voehler; L Zhou; M Passarelli; Constance M Harris; Thomas Harris; Michael P Stone
Major groove (S)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the S(61,2) and S(61,3) sequence isomers from 1H NMR.
Biochemistry 1996;35(23):7316-29.
1996: I S Zegar; S J Kim; T N Johansen; P J Horton; Constance M Harris; Thomas Harris; Michael P Stone
Adduction of the human N-ras codon 61 sequence with (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene: structural refinement of the intercalated SRSR(61,2) (-)-(7S,8R,9S,10R)-N6-[10-(7,8,9,10- tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR.
Biochemistry 1996;35(20):6212-24.
1996: I S Zegar; F R Setayesh; B L DeCorte; Constance M Harris; Thomas Harris; Michael P Stone
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12 sequence: structural refinement of the minor groove R(12,2)- and S(12,2)-alpha-(N2-guanyl) stereoisomers from 1H NMR.
Biochemistry 1996;35(14):4334-48.
1996: B L DeCorte; D Tsarouhtsis; S Kuchimanchi; M D Cooper; P Horton; Constance M Harris; Thomas Harris
Improved strategies for postoligomerization synthesis of oligodeoxynucleotides bearing structurally defined adducts at the N2 position of deoxyguanosine.
Chemical research in toxicology 1996;9(3):630-7.
1995: B Feng; L Zhou; M Passarelli; Constance M Harris; Thomas Harris; Michael P Stone
Major groove (R)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the R(61,2) and R(61,3) sequence isomers from 1H NMR.
Biochemistry 1995;34(43):14021-36.
1995: S J Kim; H K Jajoo; Hye-Young H Kim; L Zhou; P Horton; Constance M Harris; Thomas Harris
An efficient route to N6 deoxyadenosine adducts of diol epoxides of carcinogenic polycyclic aromatic hydrocarbons.
Bioorganic & medicinal chemistry 1995;3(6):811-22.
1995: G J Latham; Constance M Harris; Thomas Harris; R Stephen Lloyd
The efficiency of translesion synthesis past single styrene oxide DNA adducts in vitro is polymerase-specific.
Chemical research in toxicology 1995;8(3):422-30.
1995: P Chary; G J Latham; D L Robberson; S J Kim; S Han; Constance M Harris; Thomas Harris; R Stephen Lloyd
In vivo and in vitro replication consequences of stereoisomeric benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the second position of N-ras codon 61.
The Journal of biological chemistry 1995;270(10):4990-5000.
1993: G J Latham; L Zhou; Constance M Harris; Thomas Harris; R Stephen Lloyd
The replication fate of R- and S-styrene oxide adducts on adenine N6 is dependent on both the chirality of the lesion and the local sequence context.
The Journal of biological chemistry 1993;268(31):23427-34.
1990: B M Wickwire; Constance M Harris; Thomas Harris; H P Broquist
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. I. The lysine saccharopine, delta 1-piperideine-6-carboxylic acid pathway.
The Journal of biological chemistry 1990;265(25):14742-7.
1988: Thomas Harris; Michael P Stone; Constance M Harris
Applications of NMR spectroscopy to studies of reactive intermediates and their interactions with nucleic acids.
Chemical research in toxicology 1988;1(2):79-96.