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Constance Harris
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Research Profile (preview)
Chemicals & Drugs
Genes & Molecular Sequences
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Phenomena
Procedures
Physiology
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Network (preview)
55
Harris, Thomas
29
Stone, Michael
24
Lloyd, Stephen
20
Nechev, Lubomir
10
Tamura, Pamela
8
Kim, Hye-Young
7
Merritt, Keither
6
Scholdberg, Tandace
5
Kowalczyk, Agnieszka
4
Kanuri, Manorama
4
Li, Z
4
Carmical, Russ
4
Wilkinson, Amanda
3
Zegar, IS
3
Dean, Stephen
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All Publications
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2009: Huang Hai; Dooley Patricia A; Harris Constance M; Harris Thomas M; Stone Michael P
Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.
Chemical research in toxicology 2009;22(11):1810-6.
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2009: Brown Kyle L; Voehler Markus W; Magee Shane M; Harris Constance M; Harris Thomas M; Stone Michael P
Structural perturbations induced by the alpha-anomer of the aflatoxin B(1) formamidopyrimidine adduct in duplex and single-strand DNA.
Journal of the American Chemical Society 2009;131(44):16096-107.
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2007: Xu Wen; Merritt W Keither; Nechev Lubomir V; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.
Chemical research in toxicology 2007;20(2):187-98.
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2006: Brown Kyle L; Deng James Z; Iyer Rajkumar S; Iyer Lalitha G; Voehler Markus W; Stone Michael P; Harris Constance M; Harris Thomas M
Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.
Journal of the American Chemical Society 2006;128(47):15188-99.
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2005: Kanuri Manorama; Nechev Lubomir V; Kiehna Sarah E; Tamura Pamela J; Harris Constance M; Harris Thomas M; Lloyd R Stephen
Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks.
DNA repair 2005;4(12):1374-80.
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2005: Merritt W Keither; Nechev Lubomir V; Scholdberg Tandace A; Dean Stephen M; Kiehna Sarah E; Chang Johanna C; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.
Biochemistry 2005;44(30):10081-92.
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2005: Merritt W Keither; Kowalczyk Agnieszka; Scholdberg Tandace A; Dean Stephen M; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adducts: a structural perspective.
Chemical research in toxicology 2005;18(7):1098-107.
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2005: Scholdberg Tandace A; Merritt W Keither; Dean Stephen M; Kowalcyzk Agnieska; Harris Constance M; Harris Thomas M; Rizzo Carmelo J; Lloyd R Stephen; Stone Michael P
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.
Biochemistry 2005;44(9):3327-37.
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2005: Scholdberg Tandace A; Nechev Lubomir V; Merritt W Keither; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction.
Chemical research in toxicology 2005;18(2):145-53.
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2004: Merritt W Keither; Scholdberg Tandace A; Nechev Lubomir V; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Stereospecific structural perturbations arising from adenine N(6) butadiene triol adducts in duplex DNA.
Chemical research in toxicology 2004;17(8):1007-19.
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2004: Scholdberg Tandace A; Nechev Lubomir V; Merritt W Keither; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Structure of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA adduct of butadiene diol epoxide.
Chemical research in toxicology 2004;17(6):717-30.
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2003: Kim Hye-Young H; Wilkinson Amanda S; Harris Constance M; Harris Thomas M; Stone Michael P
Minor groove orientation for the (1S,2R,3S,4R)-N2- [1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyguanosyl adduct in the N-ras codon 12 sequence.
Biochemistry 2003;42(8):2328-38.
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2003: Dooley Patricia A; Zhang Mingzhou; Korbel Gregory A; Nechev Lubomir V; Harris Constance M; Stone Michael P; Harris Thomas M
NMR determination of the conformation of a trimethylene interstrand cross-link in an oligodeoxynucleotide duplex containing a 5'-d(GpC) motif.
Journal of the American Chemical Society 2003;125(1):62-72.
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2003: Kozekov Ivan D; Nechev Lubomir V; Moseley M Scott; Harris Constance M; Rizzo Carmelo J; Stone Michael P; Harris Thomas M
DNA interchain cross-links formed by acrolein and crotonaldehyde.
Journal of the American Chemical Society 2003;125(1):50-61.
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2002: Kanuri Manorama; Nechev Lubomir V; Tamura Pamela J; Harris Constance M; Harris Thomas M; Lloyd R Stephen
Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells.
Chemical research in toxicology 2002;15(12):1572-80.
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2002: Kanuri Manorama; Minko Irina G; Nechev Lubomir V; Harris Thomas M; Harris Constance M; Lloyd R Stephen
Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells.
The Journal of biological chemistry 2002;277(21):18257-65.
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2002: Kowalczyk Agnieszka; Carmical J Russ; Zou Yue; Van Houten Bennett; Lloyd R Stephen; Harris Constance M; Harris Thomas M
Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines.
Biochemistry 2002;41(9):3109-18.
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2001: Nechev L V; Kozekov I; Harris C M; Harris T M
Stereospecific synthesis of oligonucleotides containing crotonaldehyde adducts of deoxyguanosine.
Chemical research in toxicology 2001;14(11):1506-12.
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2001: Kozekov I D; Nechev L V; Sanchez A; Harris C M; Lloyd R S; Harris T M
Interchain cross-linking of DNA mediated by the principal adduct of acrolein.
Chemical research in toxicology 2001;14(11):1482-5.
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2001: Kim H Y; Cooper M; Nechev L V; Harris C M; Harris T M
Synthesis and characterization of nucleosides and oligonucleotides with a benzo[a]pyren-6-ylmethyl adduct at adenine N6 or guanine N2.
Chemical research in toxicology 2001;14(9):1306-14.
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2001: Hennard C; Finneman J; Harris C M; Harris T M; Stone M P
The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.
Biochemistry 2001;40(33):9780-91.
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2001: Kowalczyk A; Harris C M; Harris T M
Synthesis and characterization of oligodeoxynucleotides containing an N1 beta-hydroxyalkyl adduct of 2'-deoxyinosine.
Chemical research in toxicology 2001;14(6):746-53.
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2001: Li Z; Tamura P J; Wilkinson A S; Harris C M; Harris T M; Stone M P
Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects.
Biochemistry 2001;40(23):6743-55.
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2001: Harris T M; Harris C M
Synthesis of N2-substituted deoxyguanosine nucleosides from 2-fluoro-6-O-(trimethylsilylethyl)-2'-deoxyinosine.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 1():Unit 1.3.
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2001: Nechev L V; Zhang M; Tsarouhtsis D; Tamura P J; Wilkinson A S; Harris C M; Harris T M
Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2).
Chemical research in toxicology 2001;14(4):379-88.
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2001: VanderVeen L A; Hashim M F; Nechev L V; Harris T M; Harris C M; Marnett L J
Evaluation of the mutagenic potential of the principal DNA adduct of acrolein.
The Journal of biological chemistry 2001;276(12):9066-70.
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2001: Dooley P A; Tsarouhtsis D; Korbel G A; Nechev L V; Shearer J; Zegar I S; Harris C M; Stone M P; Harris T M
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-link.
Journal of the American Chemical Society 2001;123(8):1730-9.
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2001: Kanuri M; Finneman J; Harris C M; Harris T M; Lloyd R S
Efficient nonmutagenic replication bypass of DNAs containing beta-adducts of styrene oxide at adenine N(6).
Environmental and molecular mutagenesis 2001;38(4):357-60.
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2001: Rodriguez D A; Kowalczyk A; Ward J B; Harris C M; Harris T M; Lloyd R S
Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts.
Environmental and molecular mutagenesis 2001;38(4):292-6.
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2000: Kim H Y; Finneman J I; Harris C M; Harris T M
Studies of the mechanisms of adduction of 2'-deoxyadenosine with styrene oxide and polycyclic aromatic hydrocarbon dihydrodiol epoxides.
Chemical research in toxicology 2000;13(7):625-37.
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2000: Carmical J R; Kowalczyk A; Zou Y; Van Houten B; Nechev L V; Harris C M; Harris T M; Lloyd R S
Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis.
The Journal of biological chemistry 2000;275(26):19482-9.
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2000: Nechev L V; Harris C M; Harris T M
Synthesis of nucleosides and oligonucleotides containing adducts of acrolein and vinyl chloride.
Chemical research in toxicology 2000;13(5):421-9.
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2000: Le P T; Harris C M; Harris T M; Stone M P
Altered electrophoretic migration of polycyclic aromatic hydrocarbon and styrene oxide adducts at adenine N(6) correlates with adduct-induced structural disorder.
Chemical research in toxicology 2000;13(2):63-71.
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2000: Simeonov M F; Tamura P J; Wilkinson A S; Harris C M; Harris T M; Stone M P
Sequence- and stereospecific conformational rearrangement of styrene oxide adducts located at A x C mismatched base pairs.
Biochemistry 2000;39(5):924-37.
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2000: Carmical J R; Zhang M; Nechev L; Harris C M; Harris T M; Lloyd R S
Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide.
Chemical research in toxicology 2000;13(1):18-25.
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2000: Carmical J R; Nechev L V; Harris C M; Harris T M; Lloyd R S
Mutagenic potential of adenine N(6) adducts of monoepoxide and diolepoxide derivatives of butadiene.
Environmental and molecular mutagenesis 2000;35(1):48-56.
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1999: Li Z; Kim H Y; Tamura P J; Harris C M; Harris T M; Stone M P
Intercalation of the (1S,2R,3S,4R)-N6-[1-(1,2,3,4-tetrahydro-2,3, 4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(49):16045-57.
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1999: Li Z; Kim H Y; Tamura P J; Harris C M; Harris T M; Stone M P
Role of a polycyclic aromatic hydrocarbon bay region ring in modulating DNA adduct structure: the non-bay region (8S,9R,10S, 11R)-N(6)-[11-(8,9,10,11-tetrahydro-8,9, 10-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in codon 61 of the human N-ras protooncogene.
Biochemistry 1999;38(45):14820-32.
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1999: Gurvich V; Kim H Y; Hodge R P; Harris C M; Harris T M
Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides.
Nucleosides & nucleotides 1999;18(10):2327-33.
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1999: Painter S L; Zegar I S; Tamura P J; Bluhm S; Harris C M; Harris T M; Stone M P
Influence of the R(61,2)- and S(61,2)-alpha-(N6-adenyl)styrene oxide adducts on the A.C mismatched base pair in an oligodeoxynucleotide containing the human N-ras codon 61.
Biochemistry 1999;38(27):8635-46.
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1999: Li Z; Mao H; Kim H Y; Tamura P J; Harris C M; Harris T M; Stone M P
Intercalation of the (-)-(1R,2S,3R, 4S)-N6-[1-benz[a]anthracenyl]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(10):2969-81.
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1998: Zegar I S; Chary P; Jabil R J; Tamura P J; Johansen T N; Lloyd R S; Harris C M; Harris T M; Stone M P
Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.
Biochemistry 1998;37(47):16516-28.
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1998: Setayesh F R; DeCorte B L; Horton P; Harris C M; Harris T M; Stone M P
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12: minor groove structures of the R(12,1)- and S(12,1)-alpha-(N2-guanyl) stereoisomers determined by 1H nuclear magnetic resonance.
Chemical research in toxicology 1998;11(7):766-77.
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1997: McNees A G; O'Donnell M; Horton P H; Kim H Y; Kim S J; Harris C M; Harris T M; Lloyd R S
Lack of correlation between in vitro and in vivo replication of precisely defined benz-a-anthracene adducted DNAs.
The Journal of biological chemistry 1997;272(52):33211-9.
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1997: Chary P; Harris C M; Harris T M; Lloyd R S
Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates.
The Journal of biological chemistry 1997;272(9):5805-13.
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1996: Latham G J; McNees A G; De Corte B; Harris C M; Harris T M; O'Donnell M; Lloyd R S
Comparison of the efficiency of synthesis past single bulky DNA adducts in vivo and in vitro by the polymerase III holoenzyme.
Chemical research in toxicology 1996;9(7):1167-75.
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1996: Feng B; Voehler M; Zhou L; Passarelli M; Harris C M; Harris T M; Stone M P
Major groove (S)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the S(61,2) and S(61,3) sequence isomers from 1H NMR.
Biochemistry 1996;35(23):7316-29.
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1996: Zegar I S; Kim S J; Johansen T N; Horton P J; Harris C M; Harris T M; Stone M P
Adduction of the human N-ras codon 61 sequence with (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene: structural refinement of the intercalated SRSR(61,2) (-)-(7S,8R,9S,10R)-N6-[10-(7,8,9,10- tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR.
Biochemistry 1996;35(20):6212-24.
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1996: DeCorte B L; Tsarouhtsis D; Kuchimanchi S; Cooper M D; Horton P; Harris C M; Harris T M
Improved strategies for postoligomerization synthesis of oligodeoxynucleotides bearing structurally defined adducts at the N2 position of deoxyguanosine.
Chemical research in toxicology 1996;9(3):630-7.
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1996: Zegar I S; Setayesh F R; DeCorte B L; Harris C M; Harris T M; Stone M P
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12 sequence: structural refinement of the minor groove R(12,2)- and S(12,2)-alpha-(N2-guanyl) stereoisomers from 1H NMR.
Biochemistry 1996;35(14):4334-48.
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1995: Feng B; Zhou L; Passarelli M; Harris C M; Harris T M; Stone M P
Major groove (R)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the R(61,2) and R(61,3) sequence isomers from 1H NMR.
Biochemistry 1995;34(43):14021-36.
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1995: Kim S J; Jajoo H K; Kim H Y; Zhou L; Horton P; Harris C M; Harris T M
An efficient route to N6 deoxyadenosine adducts of diol epoxides of carcinogenic polycyclic aromatic hydrocarbons.
Bioorganic & medicinal chemistry 1995;3(6):811-22.
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1995: Latham G J; Harris C M; Harris T M; Lloyd R S
The efficiency of translesion synthesis past single styrene oxide DNA adducts in vitro is polymerase-specific.
Chemical research in toxicology 1995;8(3):422-30.
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1995: Chary P; Latham G J; Robberson D L; Kim S J; Han S; Harris C M; Harris T M; Lloyd R S
In vivo and in vitro replication consequences of stereoisomeric benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the second position of N-ras codon 61.
The Journal of biological chemistry 1995;270(10):4990-5000.
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1993: Latham G J; Zhou L; Harris C M; Harris T M; Lloyd R S
The replication fate of R- and S-styrene oxide adducts on adenine N6 is dependent on both the chirality of the lesion and the local sequence context.
The Journal of biological chemistry 1993;268(31):23427-34.
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1990: Wickwire B M; Harris C M; Harris T M; Broquist H P
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. I. The lysine saccharopine, delta 1-piperideine-6-carboxylic acid pathway.
The Journal of biological chemistry 1990;265(25):14742-7.
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1988: Harris T M; Stone M P; Harris C M
Applications of NMR spectroscopy to studies of reactive intermediates and their interactions with nucleic acids.
Chemical research in toxicology 1988;1(2):79-96.
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