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David Harris

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Brian R Fluharty; Gianluigi Forloni; Marco Gobbi; Claudia Balducci; Emiliano Biasini; Tiziana Borsello; Laura Colombo; Luisa Diomede; Pietro La Vitola; Massimo Messa; Alessandra Sclip; Matteo Stravalaci; David A Harris
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.
Emiliano Biasini; Valentina Bonetto; Frederick P Bowman; Roberto Chiesa; Jennifer Luebke; Tania Massignan; Assunta Senatore; Isaac H Solomon; Paul Toselli; Ursula Unterberger; Till Voigtlaender; Hejiao Bian; David A Harris
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.
Emiliano Biasini; David A Harris
Targeting the cellular prion protein to treat neurodegeneration.

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All Publications

2013: Brian R Fluharty; Gianluigi Forloni; Marco Gobbi; Claudia Balducci; Emiliano Biasini; Tiziana Borsello; Laura Colombo; Luisa Diomede; Pietro La Vitola; Massimo Messa; Alessandra Sclip; Matteo Stravalaci; David A Harris
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.
The Journal of biological chemistry 2013;288(11):7857-66.
2013: Emiliano Biasini; Valentina Bonetto; Frederick P Bowman; Roberto Chiesa; Jennifer Luebke; Tania Massignan; Assunta Senatore; Isaac H Solomon; Paul Toselli; Ursula Unterberger; Till Voigtlaender; Hejiao Bian; David A Harris
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(6):2408-18.
2012: Emiliano Biasini; David A Harris
Targeting the cellular prion protein to treat neurodegeneration.
Future medicinal chemistry 2012;4(13):1655-8.
2012: Jessie A Turnbaugh; Ursula Unterberger; Emiliano Biasini; Frederick P Bowman; Brian R Fluharty; Tania Massignan; Michael B Miller; Paula Saá; Surachai Supattapone; David A Harris
The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(26):8817-30.
2012: Emiliano Biasini; Jessie A Turnbaugh; Ursula Unterberger; David A Harris
Prion protein at the crossroads of physiology and disease.
Trends in neurosciences 2012;35(2):92-103.
2012: Isaac H Solomon; Emiliano Biasini; David A Harris
Ion channels induced by the prion protein: mediators of neurotoxicity.
Prion 2012;6(1):40-5.
2012: Emiliano Biasini; Valentina Bonetto; Roberto Chiesa; Gianluigi Forloni; Tania Massignan; Jessie A Turnbaugh; Pietro Veglianese; David A Harris
The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells.
PloS one 2012;7(3):e33472.
2011: Laura Westergard; Jessie A Turnbaugh; David A Harris
A nine amino acid domain is essential for mutant prion protein toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(39):14005-17.
2011: Jessie A Turnbaugh; Ursula Unterberger; Laura Westergard; Emiliano Biasini; David A Harris
The N-terminal, polybasic region is critical for prion protein neuroprotective activity.
PloS one 2011;6(9):e25675.
2010: Isaac H Solomon; James E Huettner; David A Harris
Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells.
The Journal of biological chemistry 2010;285(34):26719-26.
2010: Mingjie Li; Nada Husic; Ying Lin; Heather Christensen; Ibrahim Malik; Sally McIver; David A Harris; Paul T Kotzbauer; Mark P Goldberg; Christine M LaPash Daniels; B Joy Snider
Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.
Journal of neuroscience methods 2010;189(1):56-64.
2010: Tania Massignan; Emiliano Biasini; Eliana Lauranzano; Pietro Veglianese; Mauro Pignataro; Luana Fioriti; David A Harris; Mario Salmona; Roberto Chiesa; Valentina Bonetto
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.
Molecular & cellular proteomics : MCP 2010;9(4):611-22.
2010: Tania Massignan; Richard S Stewart; Emiliano Biasini; Isaac H Solomon; Valentina Bonetto; Roberto Chiesa; David A Harris
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.
The Journal of biological chemistry 2010;285(10):7752-65.
2010: Isaac H Solomon; Jessie A Schepker; David A Harris
Prion neurotoxicity: insights from prion protein mutants.
Current issues in molecular biology 2010;12(2):51-61.
2009: Martin Jeffrey; Caroline M Goodsir; Gillian McGovern; Sami J Barmada; Andrea Z Medrano; David A Harris
Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.
The American journal of pathology 2009;175(3):1208-17.
2009: Roberto Chiesa; David A Harris
Fishing for prion protein function.
PLoS biology 2009;7(3):e75.
2009: Emiliano Biasini; Laura Tapella; Susanna Mantovani; Matteo Stravalaci; Marco Gobbi; David A Harris; Roberto Chiesa
Immunopurification of pathological prion protein aggregates.
PloS one 2009;4(11):e7816.
2009: Heather M Christensen; David A Harris
A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells.
Journal of neurochemistry 2009;108(1):44-56.
2008: Roberto Chiesa; Pedro Piccardo; Emiliano Biasini; Bernardino Ghetti; David A Harris
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(49):13258-67.
2008: Christopher S Greil; Ina M Vorberg; Anne E Ward; Kimberly D Meade-White; David A Harris; Suzette A Priola
Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.
Virology 2008;379(2):284-93.
2008: Andrea Z Medrano; Sami J Barmada; Emiliano Biasini; David A Harris
GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice.
Neurobiology of disease 2008;31(1):20-32.
2008: Emiliano Biasini; M Esa Seegulam; Brianna N Patti; Laura Solforosi; Andrea Z Medrano; Heather M Christensen; Assunta Senatore; Roberto Chiesa; R Anthony Williamson; David A Harris
Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies.
Journal of neurochemistry 2008;105(6):2190-204.
2008: Emiliano Biasini; Andrea Z Medrano; Stefano Thellung; Roberto Chiesa; David A Harris
Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion.
Journal of neurochemistry 2008;104(5):1293-308.
2008: Heather M Christensen; David A Harris
Prion protein lacks robust cytoprotective activity in cultured cells.
Molecular neurodegeneration 2008;3():11.
2007: Jiaxin Dong; Aimin Li; Naohiro Yamaguchi; Suehiro Sakaguchi; David A Harris
Doppel induces degeneration of cerebellar Purkinje cells independently of Bax.
The American journal of pathology 2007;171(2):599-607.
2007: Elizabeth M H Tank; David A Harris; Amar A Desai; Heather True
Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability.
Molecular and cellular biology 2007;27(15):5445-55.
2007: Aimin Li; Pedro Piccardo; Sami J Barmada; Bernardino Ghetti; David A Harris
Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice.
The EMBO journal 2007;26(11):2777-85.
2007: Laura Westergard; Heather M Christensen; David A Harris
The cellular prion protein (PrP(C)): its physiological function and role in disease.
Biochimica et biophysica acta 2007;1772(6):629-44.
2007: Shaoman Yin; Nancy Pham; Shuiliang Yu; Chaoyang Li; Poki Wong; Binggong Chang; Shin-Chung Kang; Emiliano Biasini; Po Tien; David A Harris; Man-Sun Sy
Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7546-51.
2007: Aimin Li; Sami J Barmada; Kevin A Roth; David A Harris
N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):852-9.
2007: Aimin Li; Heather M Christensen; Leanne R Stewart; Kevin A Roth; Roberto Chiesa; David A Harris
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.
The EMBO journal 2007;26(2):548-58.
2006: Asis Khan; Ulrike Böhme; Krystyna A Kelly; Ellen Adlem; Karen Brooks; Mark Simmonds; Karen Mungall; Michael A Quail; Claire Arrowsmith; Tracey Chillingworth; Carol Churcher; David A Harris; Matthew Collins; Nigel Fosker; Audrey Fraser; Zahra Hance; Kay Jagels; Sharon Moule; Lee Murphy; Susan O'Neil; Marie-Adele Rajandream; David Saunders; kathy seeger; Sally Whitehead; Thomas Mayr; Xuenan Xuan; Junichi Watanabe; Yutaka Suzuki; Hiroyuki Wakaguri; Sumio Sugano; Chihiro Sugimoto; Ian Paulsen; Aaron J Mackey; David S Roos; Neil Hall; Matthew Berriman; Bart Barrell; L David Sibley; James W Ajioka
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii.
Genome research 2006;16(9):1119-25.
2006: David A Harris; Heather True
New insights into prion structure and toxicity.
Neuron 2006;50(3):353-7.
2005: Sami J Barmada; David A Harris
Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(24):5824-32.
2005: Aimin Li; David A Harris
Mammalian prion protein suppresses Bax-induced cell death in yeast.
The Journal of biological chemistry 2005;280(17):17430-4.
2005: Richard S Stewart; David A Harris
A transmembrane form of the prion protein is localized in the Golgi apparatus of neurons.
The Journal of biological chemistry 2005;280(16):15855-64.
2005: Richard S Stewart; Pedro Piccardo; Bernardino Ghetti; David A Harris
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(13):3469-77.
2005: Luana Fioriti; Sara Dossena; Leanne R Stewart; Richard S Stewart; David A Harris; Gianluigi Forloni; Roberto Chiesa
Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations.
The Journal of biological chemistry 2005;280(12):11320-8.
2005: Roberto Chiesa; Pedro Piccardo; Sara Dossena; Lisa Nowoslawski; Kevin A Roth; Bernardino Ghetti; David A Harris
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):238-43.
2005: Luana Fioriti; Elena Quaglio; Tania Massignan; Laura Colombo; Richard S Stewart; Mario Salmona; David A Harris; Gianluigi Forloni; Roberto Chiesa
The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species.
Molecular and cellular neurosciences 2005;28(1):165-76.
2004: Sami J Barmada; Pedro Piccardo; Keiji Yamaguchi; Bernardino Ghetti; David A Harris
GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice.
Neurobiology of disease 2004;16(3):527-37.
2004: Aimin Li; Jiaxin Dong; David A Harris
Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes.
The Journal of biological chemistry 2004;279(28):29469-77.
2003: Richard S Stewart; David A Harris
Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection.
The Journal of biological chemistry 2003;278(46):45960-8.
2003: Lesley R Brown; David A Harris
Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi.
Journal of neurochemistry 2003;87(2):353-63.
2003: Roberto Chiesa; Pedro Piccardo; Elena Quaglio; Bettina Drisaldi; San Ling Si-Hoe; Masaki Takao; Bernardino Ghetti; David A Harris
Molecular distinction between pathogenic and infectious properties of the prion protein.
Journal of virology 2003;77(13):7611-22.
2003: Bettina Drisaldi; Richard S Stewart; Cheryl Adles; Leanne R Stewart; Elena Quaglio; Emiliano Biasini; Luana Fioriti; Roberto Chiesa; David A Harris
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation.
The Journal of biological chemistry 2003;278(24):21732-43.
2003: Nathan R Deleault; Patrick J Dolph; Mel B Feany; Meghan E Cook; Koren Nishina; David A Harris; Surachai Supattapone
Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons.
Journal of neurochemistry 2003;85(6):1614-23.
2003: David A Harris; Roberto Chiesa; Bettina Drisaldi; Elena Quaglio; antonio migheli; Pedro Piccardo; Bernardino Ghetti
A murine model of a familial prion disease.
Clinics in laboratory medicine 2003;23(1):175-86.
2003: David A Harris
Trafficking, turnover and membrane topology of PrP.
British medical bulletin 2003;66():71-85.
2001: L Ivanova; Sami J Barmada; T Kummer; David A Harris
Mutant prion proteins are partially retained in the endoplasmic reticulum.
The Journal of biological chemistry 2001;276(45):42409-21.
2001: Elena Quaglio; Roberto Chiesa; David A Harris
Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform.
The Journal of biological chemistry 2001;276(14):11432-8.
2001: Roberto Chiesa; A Pestronk; R E Schmidt; W G Tourtellotte; Bernardino Ghetti; Pedro Piccardo; David A Harris
Primary myopathy and accumulation of PrPSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation.
Neurobiology of disease 2001;8(2):279-88.
2001: Richard S Stewart; Bettina Drisaldi; David A Harris
A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic Reticulum.
Molecular biology of the cell 2001;12(4):881-9.
2001: Richard S Stewart; David A Harris
Most pathogenic mutations do not alter the membrane topology of the prion protein.
The Journal of biological chemistry 2001;276(3):2212-20.
2001: David A Harris; Roberto Chiesa; antonio migheli; Pedro Piccardo; Bernardino Ghetti
Cellular and transgenic models of familial prion diseases.
Methods in molecular medicine 2001;59():149-61.
2001: David A Harris
Biosynthesis and cellular processing of the prion protein.
Advances in protein chemistry 2001;57():203-28.
2000: David A Harris
Prion diseases.
Nutrition (Burbank, Los Angeles County, Calif.) 2000;16(7-8):554-6.
2000: R Chiesa; David A Harris
Nerve growth factor-induced differentiation does not alter the biochemical properties of a mutant prion protein expressed in PC12 cells.
Journal of neurochemistry 2000;75(1):72-80.
2000: Roberto Chiesa; Bettina Drisaldi; Elena Quaglio; antonio migheli; Pedro Piccardo; Bernardino Ghetti; David A Harris
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5574-9.
2000: DJ Waggoner; Bettina Drisaldi; Thomas B Bartnikas; RL Casareno; Joseph Prohaska; Jonathan D Gitlin; David A Harris
Brain copper content and cuproenzyme activity do not vary with prion protein expression level.
The Journal of biological chemistry 2000;275(11):7455-8.
2000: David A Harris; Roberto Chiesa; Bettina Drisaldi; Elena Quaglio; antonio migheli; Pedro Piccardo; Bernardino Ghetti
A transgenic model of a familial prion disease.
Archives of virology. Supplementum 2000;(16):103-12.
1999: R Narwa; David A Harris
Prion proteins carrying pathogenic mutations are resistant to phospholipase cleavage of their glycolipid anchors.
Biochemistry 1999;38(27):8770-7.
1999: David A Harris
Cellular biology of prion diseases.
Clinical microbiology reviews 1999;12(3):429-44.
1999: David A Harris
Cell biological studies of the prion protein.
Current issues in molecular biology 1999;1(1-2):65-75.
1998: P C Pauly; David A Harris
Copper stimulates endocytosis of the prion protein.
The Journal of biological chemistry 1998;273(50):33107-10.
1998: Roberto Chiesa; Pedro Piccardo; Bernardino Ghetti; David A Harris
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.
Neuron 1998;21(6):1339-51.
1997: S Lehmann; N Daude; David A Harris
A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells.
Brain research. Molecular brain research 1997;52(1):139-45.
1997: S Lehmann; David A Harris
Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells.
The Journal of biological chemistry 1997;272(34):21479-87.
1997: S Lehmann; Roberto Chiesa; David A Harris
Evidence for a six-transmembrane domain structure of presenilin 1.
The Journal of biological chemistry 1997;272(18):12047-51.
1997: N Daude; S Lehmann; David A Harris
Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells.
The Journal of biological chemistry 1997;272(17):11604-12.
1996: S Lehmann; David A Harris
Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5610-4.
1996: S Lehmann; David A Harris
Mutant and infectious prion proteins display common biochemical properties in cultured cells.
The Journal of biological chemistry 1996;271(3):1633-7.
1996: David A Harris; A Gorodinsky; S Lehmann; K Moulder; Show-Ling Shyng
Cell biology of the prion protein.
Current topics in microbiology and immunology 1996;207():77-93.
1995: Show-Ling Shyng; S Lehmann; K L Moulder; David A Harris
Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.
The Journal of biological chemistry 1995;270(50):30221-9.
1995: S Lehmann; David A Harris
A mutant prion protein displays an aberrant membrane association when expressed in cultured cells.
The Journal of biological chemistry 1995;270(41):24589-97.
1995: Show-Ling Shyng; K L Moulder; A Lesko; David A Harris
The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits.
The Journal of biological chemistry 1995;270(24):14793-800.
1995: A Gorodinsky; David A Harris
Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.
The Journal of cell biology 1995;129(3):619-27.
1994: Show-Ling Shyng; John Edward Heuser; David A Harris
A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.
The Journal of cell biology 1994;125(6):1239-50.
1993: Show-Ling Shyng; Mary T Huber; David A Harris
A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells.
The Journal of biological chemistry 1993;268(21):15922-8.
1993: David A Harris; P Lele; William D Snider
Localization of the mRNA for a chicken prion protein by in situ hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4309-13.
1993: David A Harris; Mary T Huber; P van Dijken; Show-Ling Shyng; Brian T Chait; R Wang
Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.
Biochemistry 1993;32(4):1009-16.
1991: David A Harris; D L Falls; F A Johnson; Gerald D Fischbach
A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7664-8.
1990: D L Falls; David A Harris; F A Johnson; M M Morgan; G Corfas; Gerald D Fischbach
Mr 42,000 ARIA: a protein that may regulate the accumulation of acetylcholine receptors at developing chick neuromuscular junctions.
Cold Spring Harbor symposia on quantitative biology 1990;55():397-406.
1989: David A Harris; D L Falls; Gerald D Fischbach
Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor.
Nature 1989;337(6203):173-6.
1988: David A Harris; D L Falls; R M Dill-Devor; Gerald D Fischbach
Acetylcholine receptor-inducing factor from chicken brain increases the level of mRNA encoding the receptor alpha subunit.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1983-7.