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MM Asaad

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TOP 3
Jeffrey A Robl; Ligaya M Simpkins; MM Asaad
N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.
NC Trippodo; M Fox; T M Monticello; B C Panchal; MM Asaad
Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril.
Jeffrey A Robl; Richard Sulsky; E Sieber-McMaster; Denis E Ryono; M P Cimarusti; Ligaya M Simpkins; D S Karanewsky; Sam Chao; MM Asaad; AA Seymour; M Fox; P L Smith; NC Trippodo
Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.

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All Publications

2000: Jeffrey A Robl; Ligaya M Simpkins; MM Asaad
N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(3):257-60.
1999: NC Trippodo; M Fox; T M Monticello; B C Panchal; MM Asaad
Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril.
Journal of cardiovascular pharmacology 1999;34(6):782-90.
1999: Jeffrey A Robl; Richard Sulsky; E Sieber-McMaster; Denis E Ryono; M P Cimarusti; Ligaya M Simpkins; D S Karanewsky; Sam Chao; MM Asaad; AA Seymour; M Fox; P L Smith; NC Trippodo
Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.
Journal of medicinal chemistry 1999;42(2):305-11.
1998: NC Trippodo; Jeffrey A Robl; MM Asaad; M Fox; B C Panchal; T R Schaeffer
Effects of omapatrilat in low, normal, and high renin experimental hypertension.
American journal of hypertension 1998;11(3 Pt 1):363-72.
1997: Jeffrey A Robl; CQ Sun; J Stevenson; Denis E Ryono; Ligaya M Simpkins; M P Cimarusti; Tamara Dejneka; William A Slusarchyk; Sam Chao; L Stratton; Raj Misra; Mark S Bednarz; MM Asaad; H S Cheung; Benoni E Abboa-Offei; P L Smith; P D Mathers; M Fox; T R Schaeffer; AA Seymour; NC Trippodo
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Journal of medicinal chemistry 1997;40(11):1570-7.
1996: AA Seymour; MM Asaad; B E Abboa-Offei; P L Smith; W L Rogers; C R Dorso
In vivo pharmacology of dual neutral endopeptidase/angiotensin-converting enzyme inhibitors.
Journal of cardiovascular pharmacology 1996;28(5):672-8.
1996: AA Seymour; MM Asaad; B E Abboa-Offei; P L Smith; P D Mathers; W L Rogers; C R Dorso
Renal and depressor activities of inhibitors of neutral endopeptidase and angiotensin converting enzyme in monkeys infused with angiotensin II.
Journal of cardiovascular pharmacology 1996;28(5):651-8.
1996: AA Seymour; P D Mathers; B E Abboa-Offei; MM Asaad; H Weber
Renal and depressor activity of C-natriuretic peptide in conscious monkeys: effects of enzyme inhibitors.
Journal of cardiovascular pharmacology 1996;28(3):397-401.
1996: C Carpenter; A A Honkanen; Hiroshi Mashimo; K A Goss; P Huang; M C Fishman; MM Asaad; C R Dorso; H Cheung
Renal abnormalities in mutant mice.
Nature 1996;380(6572):292.
1996: AA Seymour; MM Asaad; B E Abboa-Offei; P L Smith; W L Rogers; C R Dorso
Determinants of in vivo activity of neutral endopeptidase 3.4.24.11 and angiotensin converting enzyme inhibitors.
The Journal of pharmacology and experimental therapeutics 1996;276(2):708-13.
1996: Jeffrey A Robl; M P Cimarusti; Ligaya M Simpkins; B Brown; Denis E Ryono; J E Bird; MM Asaad; T R Schaeffer; NC Trippodo
Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.
Journal of medicinal chemistry 1996;39(2):494-502.
1995: J E Bird; Maria L Webb; M R Giancarli; C Chao; C R Dorso; MM Asaad
A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats.
European journal of pharmacology 1995;294(1):183-9.
1995: NC Trippodo; Jeffrey A Robl; MM Asaad; J E Bird; B C Panchal; T R Schaeffer; M Fox; M R Giancarli; H S Cheung
Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure.
The Journal of pharmacology and experimental therapeutics 1995;275(2):745-52.
1995: AA Seymour; MM Asaad; J H Sheldon; P L Smith; W L Rogers
Atrial natriuretic peptide in chronically hypertensive dogs.
Hypertension 1995;26(4):634-41.
1995: AA Seymour; B E Abboa-Offei; P L Smith; P D Mathers; MM Asaad; W L Rogers
Potentiation of natriuretic peptides by neutral endopeptidase inhibitors.
Clinical and experimental pharmacology & physiology 1995;22(1):63-9.
1994: AA Seymour; MM Asaad; B Abboa-Offei; P L Smith; W L Rogers
Sodium loads enhance the natriuretic responses to atrial natriuretic peptide and neutral endopeptidase inhibitors in conscious cynomolgus monkeys.
Clinical and experimental pharmacology & physiology 1994;21(11):845-56.
1994: AA Seymour; D E Burkett; MM Asaad; V M Lanoce; A F Clemons; W L Rogers
Hemodynamic, renal, and hormonal effects of rapid ventricular pacing in conscious dogs.
Laboratory animal science 1994;44(5):443-52.
1994: MM Asaad; C R Dorso; W L Rogers
Stability of plasma atrial natriuretic peptide after storage.
Circulation 1994;89(5):2457-8.
1994: AA Seymour; J H Sheldon; P L Smith; MM Asaad; W L Rogers
Potentiation of the renal responses to bradykinin by inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in anesthetized dogs.
The Journal of pharmacology and experimental therapeutics 1994;269(1):263-70.
1993: NC Trippodo; M Fox; V Natarajan; B C Panchal; C R Dorso; MM Asaad
Combined inhibition of neutral endopeptidase and angiotensin converting enzyme in cardiomyopathic hamsters with compensated heart failure.
The Journal of pharmacology and experimental therapeutics 1993;267(1):108-16.
1993: AA Seymour; MM Asaad; V M Lanoce; K M Langenbacher; S A Fennell; W L Rogers
Systemic hemodynamics, renal function and hormonal levels during inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in conscious dogs with pacing-induced heart failure.
The Journal of pharmacology and experimental therapeutics 1993;266(2):872-83.
1993: J E Bird; T L Waldron; C R Dorso; MM Asaad
Effects of the endothelin (ET) receptor antagonist BQ 123 on initial and delayed vascular responses induced by ET-1 in conscious, normotensive rats.
Journal of cardiovascular pharmacology 1993;22(1):69-73.
1993: AA Seymour; MM Asaad; V M Lanoce; S A Fennell; H S Cheung; W L Rogers
Inhibition of neutral endopeptidase 3.4.24.11 in conscious dogs with pacing induced heart failure.
Cardiovascular research 1993;27(6):1015-23.
1993: MM Asaad; C R Dorso; S M Moreland
Effects of neutral endopeptidase inhibition on the clearance of exogenously administered endothelin in Sprague-Dawley rats.
Journal of cardiovascular pharmacology 1993;21(4):633-6.
1992: AA Seymour; MM Asaad; B E Abboa-Offei; P L Rovnyak; S Fennell; W L Rogers
Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats.
The Journal of pharmacology and experimental therapeutics 1992;262(1):60-70.
1992: J E Bird; T L Waldron; D K Little; MM Asaad; C R Dorso; G DiDonato; J A Norman
The effects of novel cathepsin E inhibitors on the big endothelin pressor response in conscious rats.
Biochemical and biophysical research communications 1992;182(1):224-31.
1991: AA Seymour; B Abboa-Offei; MM Asaad; W L Rogers
Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys.
Canadian journal of physiology and pharmacology 1991;69(10):1609-17.
1991: NC Trippodo; R A Gabel; C M Harvey; MM Asaad; W L Rogers
Heart failure augments the cardiovascular and renal effects of neutral endopeptidase inhibition in rats.
Journal of cardiovascular pharmacology 1991;18(3):308-16.
1991: AA Seymour; J A Norman; MM Asaad; S A Fennell; B Abboa-Offei; D K Little; V J Kratunis; N G Delaney; John T Hunt; G Di Donato
Possible regulation of atrial natriuretic factor by neutral endopeptidase 24.11 and clearance receptors.
The Journal of pharmacology and experimental therapeutics 1991;256(3):1002-9.
1991: AA Seymour; J A Norman; MM Asaad; S A Fennell; D K Little; V J Kratunis; W L Rogers
Antihypertensive and renal activity of SQ 28,603, an inhibitor of neutral endopeptidase.
Journal of cardiovascular pharmacology 1991;17(2):296-304.
1990: AA Seymour; J A Norman; MM Asaad; S A Fennell; J N Swerdel; D K Little; C R Dorso
Renal and depressor effects of SQ 29,072, a neutral endopeptidase inhibitor, in conscious hypertensive rats.
Journal of cardiovascular pharmacology 1990;16(1):163-72.
1990: AA Seymour; J N Swerdel; S A Fennell; V J Kratunis; MM Asaad
Role of atrial natriuretic peptide in sodium balance in conscious spontaneously hypertensive rats.
The American journal of physiology 1990;258(4 Pt 2):F916-26.
1989: J M DeForrest; R J Scalese; R S Oehl; T L Waldron; S Mitch; R J Brittain; C A Free; MM Asaad; D Burkett
Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function.
Journal of hypertension 1989;7(9):763-7.
1989: J L Bergey; D R Much; V Kratunis; MM Asaad
Effects of human ANF-(99-126) on sympathetic nerve function, hemodynamic parameters and plasma cGMP levels in anesthetized, ganglion-blocked dogs.
European journal of pharmacology 1989;159(2):103-12.
1988: E M Gordon; J D Godfrey; N G Delaney; MM Asaad; D Von Langen; D W Cushman
Design of novel inhibitors of aminopeptidases. Synthesis of peptide-derived diamino thiols and sulfur replacement analogues of bestatin.
Journal of medicinal chemistry 1988;31(11):2199-211.
1987: Karnail S Atwal; B C O'Reilly; E P Ruby; C F Turk; G Aberg; MM Asaad; J L Bergey; S Moreland; J R Powell
Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects.
Journal of medicinal chemistry 1987;30(4):627-35.