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Ulrich Hartl

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Physiology

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Escherichia coli

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Florian Rüßmann; Markus J Stemp; Andreas Bracher; Stephanie A Etchells; Leonie Mönkemeyer; F Ulrich Hartl
Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT.
Yi-Chin C Tsai; F Ulrich Hartl; Oliver Mueller-Cajar; Sandra Saschenbrecker; Manajit Hayer-Hartl
Chaperonin cofactors, Cpn10 and Cpn20, of green algae and plants function as hetero-oligomeric ring complexes.
Alexander Leitner; Steve Ludtke; Boxue Ma; Leonie Mönkemeyer; Sebastian Pechmann; Thomas Walzthoeni; Ruedi Aebersold; Andreas Bracher; Bryan Chen; Wah Chiu; Yao Cong; F Ulrich Hartl; Susan Holmes; Lukasz A Joachimiak; Judith Frydman
The molecular architecture of the eukaryotic chaperonin TRiC/CCT.

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All Publications

2012: Florian Rüßmann; Markus J Stemp; Andreas Bracher; Stephanie A Etchells; Leonie Mönkemeyer; F Ulrich Hartl
Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):21208-15.
2012: Yi-Chin C Tsai; F Ulrich Hartl; Oliver Mueller-Cajar; Sandra Saschenbrecker; Manajit Hayer-Hartl
Chaperonin cofactors, Cpn10 and Cpn20, of green algae and plants function as hetero-oligomeric ring complexes.
The Journal of biological chemistry 2012;287(24):20471-81.
2012: Alexander Leitner; Steve Ludtke; Boxue Ma; Leonie Mönkemeyer; Sebastian Pechmann; Thomas Walzthoeni; Ruedi Aebersold; Andreas Bracher; Bryan Chen; Wah Chiu; Yao Cong; F Ulrich Hartl; Susan Holmes; Lukasz A Joachimiak; Judith Frydman
The molecular architecture of the eukaryotic chaperonin TRiC/CCT.
Structure (London, England : 1993) 2012;20(5):814-25.
2012: Giulia Calloni; Hung-Chun Chang; Taotao Chen; Pierre Genevaux; Manajit Hayer-Hartl; Sonya M Schermann; Gian Gaetano Tartaglia; Federico Agostini; F Ulrich Hartl
DnaK functions as a central hub in the E. coli chaperone network.
Cell reports 2012;1(3):251-64.
2012: Angus I Lamond; Michal Linial; Alexander Makarov; Ruedi Aebersold; Jens S Andersen; Wolfgang Baumeister; F Ulrich Hartl; Stevan Horning; Carol V Robinson; Luis Serrano; Mathias Uhlen; Ole Vorm; anne katrin werenskiold; Matthias Mann
Advancing cell biology through proteomics in space and time (PROSPECTS).
Molecular & cellular proteomics : MCP 2012;11(3):O112.017731.
2012: Kirti Sharma; R Martin Vabulas; Jürgen Cox; Boris Macek; Matthias Mann; Stefan Pinkert; F Ulrich Hartl
Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response.
Molecular & cellular proteomics : MCP 2012;11(3):M111.014654.
2011: Mathias Stotz; Petra Wendler; Oliver Mueller-Cajar; Andreas Bracher; Susanne Ciniawsky; F Ulrich Hartl; Manajit Hayer-Hartl
Structure of green-type Rubisco activase from tobacco.
Nature structural & molecular biology 2011;18(12):1366-70.
2011: Oliver Mueller-Cajar; Mathias Stotz; Petra Wendler; Andreas Bracher; F Ulrich Hartl; Manajit Hayer-Hartl
Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase.
Nature 2011;479(7372):194-9.
2011: F Ulrich Hartl
Chaperone-assisted protein folding: the path to discovery from a personal perspective.
Nature medicine 2011;17(10):1206-10.
2011: Andreas Bracher; F Ulrich Hartl; Amanda Starling-Windhof; Manajit Hayer-Hartl
Crystal structure of a chaperone-bound assembly intermediate of form I Rubisco.
Nature structural & molecular biology 2011;18(8):875-80.
2011: F Ulrich Hartl; Andreas Bracher; Manajit Hayer-Hartl
Molecular chaperones in protein folding and proteostasis.
Nature 2011;475(7356):324-32.
2011: Ulrike K Resenberger; Anja Harmeier; Andreas C Woerner; Jessica L Goodman; Veronika Müller; Rajaraman Krishnan; R Martin Vabulas; Hans A Kretzschmar; Susan Lindquist; F Ulrich Hartl; Gerd Multhaup; Konstanze F Winklhofer; Jörg Tatzelt
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.
The EMBO journal 2011;30(10):2057-70.
2011: R Martin Vabulas; F Ulrich Hartl
Aberrant protein interactions in amyloid disease.
Cell cycle (Georgetown, Tex.) 2011;10(10):1512-3.
2011: Heidi Olzscha; Sonya M Schermann; Andreas C Woerner; Stefan Pinkert; Michael H Hecht; Gian G Tartaglia; Michele Vendruscolo; Manajit Hayer-Hartl; F Ulrich Hartl; Ramunas M Vabulas
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.
Cell 2011;144(1):67-78.
2011: Rajat Gupta; F Ulrich Hartl; Prasad Kasturi; Christian Loew; Andreas Bracher; Dan Garza; Adriana Villella; Min Zheng; Swasti Raychaudhuri
Firefly luciferase mutants as sensors of proteome stress.
Nature methods 2011;8(10):879-84.
2010: Ramunas M Vabulas; Swasti Raychaudhuri; Manajit Hayer-Hartl; F Ulrich Hartl
Protein folding in the cytoplasm and the heat shock response.
Cold Spring Harbor perspectives in biology 2010;2(12):a004390.
2010: Sigrun Polier; F Ulrich Hartl; Andreas Bracher
Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein.
Journal of molecular biology 2010;401(5):696-707.
2010: Sathish Kumar Lakshmipathy; Rashmi Gupta; Stefan Pinkert; Stephanie A Etchells; F Ulrich Hartl
Versatility of trigger factor interactions with ribosome-nascent chain complexes.
The Journal of biological chemistry 2010;285(36):27911-23.
2010: Florian Brandt; Lars-Anders Carlson; F Ulrich Hartl; Wolfgang Baumeister; Kay Grünewald
The three-dimensional organization of polyribosomes in intact human cells.
Molecular cell 2010;39(4):560-9.
2010: Julio O Ortiz; Florian Brandt; Valério R F Matias; Lau Sennels; Juri Rappsilber; Sjors H W Scheres; Matthias Eibauer; F Ulrich Hartl; Wolfgang Baumeister
Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ.
The Journal of cell biology 2010;190(4):613-21.
2010: Rashmi Gupta; Sathish Kumar Lakshmipathy; Hung-Chun Chang; Stephanie A Etchells; F Ulrich Hartl
Trigger factor lacking the PPIase domain can enhance the folding of eukaryotic multi-domain proteins in Escherichia coli.
FEBS letters 2010;584(16):3620-4.
2010: Gian Gaetano Tartaglia; Christopher M Dobson; F Ulrich Hartl; Michele Vendruscolo
Physicochemical determinants of chaperone requirements.
Journal of molecular biology 2010;400(3):579-88.
2010: kausik chakraborty; Manal Chatila; Jyoti Sinha; Qiaoyun Shi; Bernhard C Poschner; Martin Sikor; Guoxin Jiang; Don C Lamb; F Ulrich Hartl; Manajit Hayer-Hartl
Chaperonin-catalyzed rescue of kinetically trapped states in protein folding.
Cell 2010;142(1):112-22.
2010: Cuimin Liu; Anna L Young; Amanda Starling-Windhof; Andreas Bracher; Sandra Saschenbrecker; Bharathi Vasudeva Rao; Karnam Vasudeva Rao; Otto Berninghausen; Thorsten Mielke; F Ulrich Hartl; Roland Beckmann; Manajit Hayer-Hartl
Coupled chaperone action in folding and assembly of hexadecameric Rubisco.
Nature 2010;463(7278):197-202.
2009: Angela M Hirtreiter; Giulia Calloni; Francesca Forner; Burghardt Scheibe; Magda Puype; Joel Vandekerckhove; Matthias Mann; F Ulrich Hartl; Manajit Hayer-Hartl
Differential substrate specificity of group I and group II chaperonins in the archaeon Methanosarcina mazei.
Molecular microbiology 2009;74(5):1152-68.
2009: Sarah A Broadley; F Ulrich Hartl
The role of molecular chaperones in human misfolding diseases.
FEBS letters 2009;583(16):2647-53.
2009: F Ulrich Hartl; Manajit Hayer-Hartl
Converging concepts of protein folding in vitro and in vivo.
Nature structural & molecular biology 2009;16(6):574-81.
2009: Martin Gamerdinger; Parvana Hajieva; A Murat Kaya; Uwe Wolfrum; F Ulrich Hartl; Christian Behl
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
The EMBO journal 2009;28(7):889-901.
2009: Florian Brandt; Stephanie A Etchells; Julio O Ortiz; Adrian H Elcock; F Ulrich Hartl; Wolfgang Baumeister
The native 3D organization of bacterial polysomes.
Cell 2009;136(2):261-71.
2008: Sigrun Polier; Zdravko Dragovic; F Ulrich Hartl; Andreas Bracher
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
Cell 2008;133(6):1068-79.
2008: Yun-Chi Tang; Hung-Chun Chang; kausik chakraborty; F Ulrich Hartl; Manajit Hayer-Hartl
Essential role of the chaperonin folding compartment in vivo.
The EMBO journal 2008;27(10):1458-68.
2008: Shruti Sharma; kausik chakraborty; Barbara K Müller; Nagore Astola; Yun-Chi Tang; Don C Lamb; Manajit Hayer-Hartl; F Ulrich Hartl
Monitoring protein conformation along the pathway of chaperonin-assisted folding.
Cell 2008;133(1):142-53.
2008: Katja Siegers; Bettina Bölter; Juliane P Schwarz; Ulrike M K Böttcher; Suranjana Guha; F Ulrich Hartl
TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes.
The EMBO journal 2008;27(1):301.
2008: Yasushi Ishihama; Thorsten Schmidt; Juri Rappsilber; Matthias Mann; F Ulrich Hartl; Michael J Kerner; Dmitrij Frishman
Protein abundance profiling of the Escherichia coli cytosol.
BMC genomics 2008;9():102.
2008: Sarah A Broadley; F Ulrich Hartl
Mitochondrial stress signaling: a pathway unfolds.
Trends in cell biology 2008;18(1):1-4.
2007: Silke Grallath; Juliane P Schwarz; Ulrike M K Bottcher; Andreas Bracher; F Ulrich Hartl; Katja Siegers
L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle.
EMBO reports 2007;8(11):1086.
2007: Annette Haacke; F Ulrich Hartl; Peter Breuer
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
The Journal of biological chemistry 2007;282(26):18851-6.
2007: Sandra Saschenbrecker; Andreas Bracher; Karnam Vasudeva Rao; Bharathi Vasudeva Rao; F Ulrich Hartl; Manajit Hayer-Hartl
Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco.
Cell 2007;129(6):1189-200.
2007: Sathish K Lakshmipathy; Sladjana Tomic; Christian M Kaiser; Hung-Chun Chang; Pierre Genevaux; Costa Georgopoulos; José M Barral; Arthur E Johnson; F Ulrich Hartl; Stephanie A Etchells
Identification of nascent chain interaction sites on trigger factor.
The Journal of biological chemistry 2007;282(16):12186-93.
2007: Niclas W Schiffer; Sarah A Broadley; Thomas Hirschberger; Paul Tavan; Hans A Kretzschmar; Armin Giese; Christian Haass; F Ulrich Hartl; Bettina Schmid
Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model.
The Journal of biological chemistry 2007;282(12):9195-203.
2007: Yun-Chi Tang; Hung-Chun Chang; Manajit Hayer-Hartl; F Ulrich Hartl
SnapShot: molecular chaperones, Part II.
Cell 2007;128(2):412.
2007: Hung-Chun Chang; Yun-Chi Tang; Manajit Hayer-Hartl; F Ulrich Hartl
SnapShot: molecular chaperones, Part I.
Cell 2007;128(1):212.
2006: Zdravko Dragovic; Yasuhito Shomura; Nikolay Tzvetkov; F Ulrich Hartl; Andreas Bracher
Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p.
Biological chemistry 2006;387(12):1593-600.
2006: Christian M Kaiser; Hung-Chun Chang; Vishwas R Agashe; Sathish K Lakshmipathy; Stephanie A Etchells; Manajit Hayer-Hartl; F Ulrich Hartl; José M Barral
Real-time observation of trigger factor function on translating ribosomes.
Nature 2006;444(7118):455-60.
2006: Rosalina Fonseca; Ramunas M Vabulas; F Ulrich Hartl; Tobias Bonhoeffer; U Valentin Nägerl
A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP.
Neuron 2006;52(2):239-45.
2006: Christian Behrends; Carola A Langer; Raina Boteva; Ulrike M K Böttcher; Markus J Stemp; Gregor Schaffar; Bharathi Vasudeva Rao; Armin Giese; Hans A Kretzschmar; Katja Siegers; F Ulrich Hartl
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.
Molecular cell 2006;23(6):887-97.
2006: Zdravko Dragovic; Sarah A Broadley; Yasuhito Shomura; Andreas Bracher; F Ulrich Hartl
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s.
The EMBO journal 2006;25(11):2519-28.
2006: Yun-Chi Tang; Hung-Chun Chang; Annette Roeben; Dirk Wischnewski; Nadine Wischnewski; Michael J Kerner; F Ulrich Hartl; Manajit Hayer-Hartl
Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein.
Cell 2006;125(5):903-14.
2006: Andreas Bracher; F Ulrich Hartl
Hsp90 structure: when two ends meet.
Nature structural & molecular biology 2006;13(6):478-80.
2006: Annette Roeben; Christine Kofler; István Nagy; Stephan Nickell; F Ulrich Hartl; Andreas Bracher
Crystal structure of an archaeal actin homolog.
Journal of molecular biology 2006;358(1):145-56.
2006: Annette Haacke; Sarah A Broadley; Raina Boteva; Nikolay Tzvetkov; F Ulrich Hartl; Peter Breuer
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.
Human molecular genetics 2006;15(4):555-68.
2006: Sladjana Tomic; Arthur E Johnson; F Ulrich Hartl; Stephanie A Etchells
Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains.
FEBS letters 2006;580(1):72-6.
2006: Silke Grallath; Juliane P Schwarz; Ulrike M K Böttcher; Andreas Bracher; F Ulrich Hartl; Katja Siegers
L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle.
EMBO reports 2006;7(1):78-84.
2005: Ramunas M Vabulas; F Ulrich Hartl
Protein synthesis upon acute nutrient restriction relies on proteasome function.
Science (New York, N.Y.) 2005;310(5756):1960-3.
2005: Hung-Chun Chang; Christian M Kaiser; F Ulrich Hartl; José M Barral
De novo folding of GFP fusion proteins: high efficiency in eukaryotes but not in bacteria.
Journal of molecular biology 2005;353(2):397-409.
2005: F Ulrich Hartl
Paper of the year 2004: award to Yin Wang and Iris Lorenzi.
Biological chemistry 2005;386(9):815.
2005: Markus J Stemp; Suranjana Guha; F Ulrich Hartl; José M Barral
Efficient production of native actin upon translation in a bacterial lysate supplemented with the eukaryotic chaperonin TRiC.
Biological chemistry 2005;386(8):753-7.
2005: Michael J Kerner; Dean J Naylor; Yasushi Ishihama; Tobias Maier; Hung-Chun Chang; Anna stines; Costa Georgopoulos; Dmitrij Frishman; Manajit Hayer-Hartl; Matthias Mann; F Ulrich Hartl
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.
Cell 2005;122(2):209-20.
2005: Uwe Bertsch; Konstanze F Winklhofer; Thomas Hirschberger; Jan Bieschke; Petra Frick; F Ulrich Hartl; Paul Tavan; Jörg Tatzelt; Hans A Kretzschmar; Armin Giese
Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.
Journal of virology 2005;79(12):7785-91.
2005: Andreas Bracher; F Ulrich Hartl
Towards a complete structure of Hsp90.
Structure (London, England : 1993) 2005;13(4):501-2.
2005: Yasuhito Shomura; Zdravko Dragovic; Hung-Chun Chang; Nikolay Tzvetkov; Jason C Young; Jeffrey L Brodsky; Vince Guerriero; F Ulrich Hartl; Andreas Bracher
Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.
Molecular cell 2005;17(3):367-79.
2004: Jason C Young; Vishwas R Agashe; Katja Siegers; F Ulrich Hartl
Pathways of chaperone-mediated protein folding in the cytosol.
Nature reviews. Molecular cell biology 2004;5(10):781-91.
2004: Gregor Schaffar; Peter Breuer; Raina Boteva; Christian Behrends; Nikolay Tzvetkov; Nadine Strippel; Hideki Sakahira; Katja Siegers; Manajit Hayer-Hartl; F Ulrich Hartl
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Molecular cell 2004;15(1):95-105.
2004: Stephanie A Etchells; F Ulrich Hartl
The dynamic tunnel.
Nature structural & molecular biology 2004;11(5):391-2.
2004: Vishwas R Agashe; Suranjana Guha; Hung-Chun Chang; Pierre Genevaux; Manajit Hayer-Hartl; Markus J Stemp; Costa Georgopoulos; F Ulrich Hartl; José M Barral
Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed.
Cell 2004;117(2):199-209.
2004: Gabriela M Wochnik; Jason C Young; Ulrike Schmidt; Florian Holsboer; F Ulrich Hartl; Theo Rein
Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.
FEBS letters 2004;560(1-3):35-8.
2004: José M Barral; Sarah A Broadley; Gregor Schaffar; F Ulrich Hartl
Roles of molecular chaperones in protein misfolding diseases.
Seminars in cell & developmental biology 2004;15(1):17-29.
2004: Pierre Genevaux; France Keppel; francoise schwager; Petra S Langendijk-Genevaux; F Ulrich Hartl; Costa Georgopoulos
In vivo analysis of the overlapping functions of DnaK and trigger factor.
EMBO reports 2004;5(2):195-200.
2004: Luis Figueiredo; Daniel Klunker; Debbie Ang; Dean J Naylor; Michael J Kerner; Costa Georgopoulos; F Ulrich Hartl; Manajit Hayer-Hartl
Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation.
The Journal of biological chemistry 2004;279(2):1090-9.
2003: Katja Siegers; Bettina Bölter; Juliane P Schwarz; Ulrike M K Böttcher; Suranjana Guha; F Ulrich Hartl
TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes.
The EMBO journal 2003;22(19):5230-40.
2003: Marcus C Rosenhagen; Csaba Söti; Ulrike Schmidt; Gabriela M Wochnik; F Ulrich Hartl; Florian Holsboer; Jason C Young; Theo Rein
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):1991-2001.
2003: F Ulrich Hartl
Paper of the Year 2002: Award to Cordelia Schiene-Fischer.
Biological chemistry 2003;384(9):1253-4.
2003: Daniel Klunker; Bernd Haas; Angela Hirtreiter; Luis Figueiredo; Dean J Naylor; Günter Pfeifer; Volker Müller; Uwe Deppenmeier; Gerhard Gottschalk; F Ulrich Hartl; Manajit Hayer-Hartl
Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei.
The Journal of biological chemistry 2003;278(35):33256-67.
2003: Alexander Brychzy; Theo Rein; Konstanze F Winklhofer; F Ulrich Hartl; Jason C Young; Wolfgang M J Obermann
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
The EMBO journal 2003;22(14):3613-23.
2003: Jason C Young; F Ulrich Hartl
A stress sensor for the bacterial periplasm.
Cell 2003;113(1):1-2.
2003: Ulrike Schmidt; Gabriela M Wochnik; Marcus C Rosenhagen; Jason C Young; F Ulrich Hartl; Florian Holsboer; Theo Rein
Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor.
The Journal of biological chemistry 2003;278(7):4926-31.
2003: Fei Dou; William Netzer; Kentaro Tanemura; Feng Li; F Ulrich Hartl; Akihiko Takashima; Gunnar K Gouras; Paul Greengard; Huaxi Xu
Chaperones increase association of tau protein with microtubules.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):721-6.
2003: Jason C Young; Nicholas J Hoogenraad; F Ulrich Hartl
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.
Cell 2003;112(1):41-50.
2002: Hideki Sakahira; Peter Breuer; Manajit Hayer-Hartl; F Ulrich Hartl
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16412-8.
2002: Thalia Becker; F Ulrich Hartl; Felix Wieland
CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes.
The Journal of cell biology 2002;158(7):1277-85.
2002: Holger Sondermann; Albert K Ho; Laura L Listenberger; Katja Siegers; Ismail Moarefi; Susan R Wente; F Ulrich Hartl; Jason C Young
Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae.
The Journal of biological chemistry 2002;277(36):33220-7.
2002: Jason C Young; F Ulrich Hartl
Chaperones and transcriptional regulation by nuclear receptors.
Nature structural biology 2002;9(9):640-2.
2002: Achim Brinker; Clemens Scheufler; Florian Von Der Mulbe; Burkhard Fleckenstein; Christian Herrmann; Gunther Jung; Ismail Moarefi; F Ulrich Hartl
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes.
The Journal of biological chemistry 2002;277(22):19265-75.
2002: F Ulrich Hartl; Manajit Hayer-Hartl
Molecular chaperones in the cytosol: from nascent chain to folded protein.
Science (New York, N.Y.) 2002;295(5561):1852-8.
2002: José M Barral; Alex H Hutagalung; Achim Brinker; F Ulrich Hartl; Henry F Epstein
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin.
Science (New York, N.Y.) 2002;295(5555):669-71.
2001: J Stöckel; F Ulrich Hartl
Chaperonin-mediated de novo generation of prion protein aggregates.
Journal of molecular biology 2001;313(4):861-72.
2001: Achim Brinker; Günter Pfeifer; Michael J Kerner; Dean J Naylor; F Ulrich Hartl; Manajit Hayer-Hartl
Dual function of protein confinement in chaperonin-assisted protein folding.
Cell 2001;107(2):223-33.
2001: Konstanze F Winklhofer; F Ulrich Hartl; Jörg Tatzelt
A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds.
FEBS letters 2001;503(1):41-5.
2001: Jason C Young; Ismail Moarefi; F Ulrich Hartl
Hsp90: a specialized but essential protein-folding tool.
The Journal of cell biology 2001;154(2):267-73.
2001: A Sittler; Rudi Lurz; G Lueder; J Priller; Hans Lehrach; Manajit Hayer-Hartl; F Ulrich Hartl; Erich E Wanker
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
Human molecular genetics 2001;10(12):1307-15.
2001: Marcus C Rosenhagen; Jason C Young; Gabriela M Wochnik; Alexandra S Herr; Ulrike Schmidt; F Ulrich Hartl; Florian Holsboer; Theo Rein
Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.
Biological chemistry 2001;382(3):499-504.
2001: Holger Sondermann; Clemens Scheufler; C Schneider; J Hohfeld; F Ulrich Hartl; Ismail Moarefi
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.
Science (New York, N.Y.) 2001;291(5508):1553-7.
2001: D J Naylor; F Ulrich Hartl
Contribution of molecular chaperones to protein folding in the cytoplasm of prokaryotic and eukaryotic cells.
Biochemical Society symposium 2001;(68):45-68.
2000: Marcus Fändrich; MA Tito; MR Leroux; A A Rostom; F Ulrich Hartl; Christopher M Dobson; Carol V Robinson
Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14151-5.
2000: Holger Sondermann; T Becker; M Mayhew; F Wieland; F Ulrich Hartl
Characterization of a receptor for heat shock protein 70 on macrophages and monocytes.
Biological chemistry 2000;381(12):1165-74.
2000: R Siegert; MR Leroux; Clemens Scheufler; F Ulrich Hartl; Ismail Moarefi
Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins.
Cell 2000;103(4):621-32.
2000: Jason C Young; F Ulrich Hartl
Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.
The EMBO journal 2000;19(21):5930-40.
2000: Paul J Muchowski; Gregor Schaffar; A Sittler; Erich E Wanker; Manajit Hayer-Hartl; F Ulrich Hartl
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7841-6.
2000: A A Rostom; Paola Fucini; DR Benjamin; R Juenemann; Knud H Nierhaus; F Ulrich Hartl; Christopher M Dobson; Carol V Robinson
Detection and selective dissociation of intact ribosomes in a mass spectrometer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5185-90.
2000: Clemens Scheufler; Achim Brinker; Gleb P Bourenkov; Stefano Pegoraro; Luis Moroder; Hans D Bartunik; F Ulrich Hartl; Ismail Moarefi
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine.
Cell 2000;101(2):199-210.
2000: MR Leroux; F Ulrich Hartl
Protein folding: versatility of the cytosolic chaperonin TRiC/CCT.
Current biology : CB 2000;10(7):R260-4.
2000: Yoichi Moroi; M Mayhew; Jiri Trcka; M H Hoe; Y Takechi; F Ulrich Hartl; James E Rothman; Alan N Houghton
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3485-90.
2000: Vishwas R Agashe; F Ulrich Hartl
Roles of molecular chaperones in cytoplasmic protein folding.
Seminars in cell & developmental biology 2000;11(1):15-25.
1999: MR Leroux; Marcus Fändrich; Daniel Klunker; Katja Siegers; Andrei N Lupas; J R Brown; Elmar Schiebel; Christopher M Dobson; F Ulrich Hartl
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
The EMBO journal 1999;18(23):6730-43.
1999: M Tector; F Ulrich Hartl
An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator.
The EMBO journal 1999;18(22):6290-8.
1999: Walid A Houry; Dmitrij Frishman; Christoph Eckerskorn; Friedrich Lottspeich; F Ulrich Hartl
Identification of in vivo substrates of the chaperonin GroEL.
Nature 1999;402(6758):147-54.
1999: S A Teter; Walid A Houry; Debbie Ang; T Tradler; D Rockabrand; G Fischer; P Blum; Costa Georgopoulos; F Ulrich Hartl
Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains.
Cell 1999;97(6):755-65.
1999: Manajit Hayer-Hartl; K L Ewalt; F Ulrich Hartl
On the role of symmetrical and asymmetrical chaperonin complexes in assisted protein folding.
Biological chemistry 1999;380(5):531-40.
1999: Katja Siegers; Thomas Waldmann; MR Leroux; K Grein; A Shevchenko; Elmar Schiebel; F Ulrich Hartl
Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system.
The EMBO journal 1999;18(1):75-84.
1998: Wolfgang M J Obermann; Holger Sondermann; A A Russo; Nikola P Pavletich; F Ulrich Hartl
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
The Journal of cell biology 1998;143(4):901-10.
1998: F Weber; France Keppel; Costa Georgopoulos; Manajit Hayer-Hartl; F Ulrich Hartl
The oligomeric structure of GroEL/GroES is required for biologically significant chaperonin function in protein folding.
Nature structural biology 1998;5(11):977-85.
1998: Jason C Young; Wolfgang M J Obermann; F Ulrich Hartl
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.
The Journal of biological chemistry 1998;273(29):18007-10.
1998: DR Benjamin; Carol V Robinson; J P Hendrick; F Ulrich Hartl; Christopher M Dobson
Mass spectrometry of ribosomes and ribosomal subunits.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7391-5.
1998: N Heyrovská; Judith Frydman; J Höhfeld; F Ulrich Hartl
Directionality of polypeptide transfer in the mitochondrial pathway of chaperone-mediated protein folding.
Biological chemistry 1998;379(3):301-9.
1998: William Netzer; F Ulrich Hartl
Protein folding in the cytosol: chaperonin-dependent and -independent mechanisms.
Trends in biochemical sciences 1998;23(2):68-73.
1997: Jason C Young; C Schneider; F Ulrich Hartl
In vitro evidence that hsp90 contains two independent chaperone sites.
FEBS letters 1997;418(1-2):139-43.
1997: K L Ewalt; J P Hendrick; Walid A Houry; F Ulrich Hartl
In vivo observation of polypeptide flux through the bacterial chaperonin system.
Cell 1997;90(3):491-500.
1997: William Netzer; F Ulrich Hartl
Recombination of protein domains facilitated by co-translational folding in eukaryotes.
Nature 1997;388(6640):343-9.
1996: C Schneider; Laura Sepp-Lorenzino; E Nimmesgern; Ouathek Ouerfelli; Samuel J Danishefsky; Neal Rosen; F Ulrich Hartl
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14536-41.
1996: M Gross; Carol V Robinson; M Mayhew; F Ulrich Hartl; S E Radford
Significant hydrogen exchange protection in GroEL-bound DHFR is maintained during iterative rounds of substrate cycling.
Protein science : a publication of the Protein Society 1996;5(12):2506-13.
1996: C Schneider; F Ulrich Hartl
Hats off to the tricorn protease.
Science (New York, N.Y.) 1996;274(5291):1323-4.
1996: Manajit Hayer-Hartl; F Weber; F Ulrich Hartl
Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP hydrolysis.
The EMBO journal 1996;15(22):6111-21.
1996: Y Minami; J Höhfeld; K Ohtsuka; F Ulrich Hartl
Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.
The Journal of biological chemistry 1996;271(32):19617-24.
1996: Y Q Qian; Dinshaw J Patel; F Ulrich Hartl; D J McColl
Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain.
Journal of molecular biology 1996;260(2):224-35.
1996: F Ulrich Hartl
Molecular chaperones in cellular protein folding.
Nature 1996;381(6583):571-9.
1996: Judith Frydman; F Ulrich Hartl
Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms.
Science (New York, N.Y.) 1996;272(5267):1497-502.
1996: M Mayhew; A C da Silva; J Martin; Hediye Erdjument-Bromage; Paul Tempst; F Ulrich Hartl
Protein folding in the central cavity of the GroEL-GroES chaperonin complex.
Nature 1996;379(6564):420-6.
1996: A Szabo; R Korszun; F Ulrich Hartl; J Flanagan
A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.
The EMBO journal 1996;15(2):408-17.
1996: M Mayhew; F Ulrich Hartl
Lord of the rings: GroES structure.
Science (New York, N.Y.) 1996;271(5246):161-2.
1995: J P Hendrick; F Ulrich Hartl
The role of molecular chaperones in protein folding.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(15):1559-69.
1995: J Höhfeld; Y Minami; F Ulrich Hartl
Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle.
Cell 1995;83(4):589-98.
1995: Manajit Hayer-Hartl; J Martin; F Ulrich Hartl
Asymmetrical interaction of GroEL and GroES in the ATPase cycle of assisted protein folding.
Science (New York, N.Y.) 1995;269(5225):836-41.
1995: A Engel; Manajit Hayer-Hartl; KN Goldie; Günter Pfeifer; Reiner Hegerl; Sylke Müller; A C da Silva; Wolfgang Baumeister; F Ulrich Hartl
Functional significance of symmetrical versus asymmetrical GroEL-GroES chaperonin complexes.
Science (New York, N.Y.) 1995;269(5225):832-6.
1995: R Hlodan; Paul Tempst; F Ulrich Hartl
Binding of defined regions of a polypeptide to GroEL and its implications for chaperonin-mediated protein folding.
Nature structural biology 1995;2(7):587-95.
1995: F Ulrich Hartl
Principles of chaperone-mediated protein folding.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;348(1323):107-12.
1995: T Waldmann; E Nimmesgern; M Nitsch; Jürgen Peters; Günter Pfeifer; Sylke Müller; J Kellermann; A Engel; F Ulrich Hartl; Wolfgang Baumeister
The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC.
European journal of biochemistry / FEBS 1995;227(3):848-56.
1995: F Ulrich Hartl; J Martin
Molecular chaperones in cellular protein folding.
Current opinion in structural biology 1995;5(1):92-102.
1994: Carol V Robinson; M Gross; S J Eyles; J J Ewbank; M Mayhew; F Ulrich Hartl; Christopher M Dobson; S E Radford
Conformation of GroEL-bound alpha-lactalbumin probed by mass spectrometry.
Nature 1994;372(6507):646-51.
1994: A Szabo; T Langer; H Schröder; J Flanagan; Bernd Bukau; F Ulrich Hartl
The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10345-9.
1994: J Martin; KN Goldie; A Engel; F Ulrich Hartl
Topology of the morphological domains of the chaperonin GroEL visualized by immuno-electron microscopy.
Biological chemistry Hoppe-Seyler 1994;375(9):635-9.
1994: J Höhfeld; F Ulrich Hartl
Post-translational protein import and folding.
Current opinion in cell biology 1994;6(4):499-509.
1994: W Z Li; P Lin; Judith Frydman; Thomas Boal; Thomas S Cardillo; L M Richard; D Toth; M A Lichtman; F Ulrich Hartl; Fred Sherman
Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast.
The Journal of biological chemistry 1994;269(28):18616-22.
1994: Judith Frydman; E Nimmesgern; K Ohtsuka; F Ulrich Hartl
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones.
Nature 1994;370(6485):111-7.
1994: Manajit Hayer-Hartl; J J Ewbank; T E Creighton; F Ulrich Hartl
Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.
The EMBO journal 1994;13(13):3192-202.
1994: J Höhfeld; F Ulrich Hartl
Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria.
The Journal of cell biology 1994;126(2):305-15.
1994: F Ulrich Hartl; R Hlodan; T Langer
Molecular chaperones in protein folding: the art of avoiding sticky situations.
Trends in biochemical sciences 1994;19(1):20-5.
1993: J Martin; S Geromanos; Paul Tempst; F Ulrich Hartl
Identification of nucleotide-binding regions in the chaperonin proteins GroEL and GroES.
Nature 1993;366(6452):279-82.
1993: J Martin; M Mayhew; T Langer; F Ulrich Hartl
The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding.
Nature 1993;366(6452):228-33.
1993: J Martin; F Ulrich Hartl
Protein folding in the cell: molecular chaperones pave the way.
Structure (London, England : 1993) 1993;1(3):161-4.
1993: J P Hendrick; T Langer; T A Davis; F Ulrich Hartl; Martin Wiedmann
Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10216-20.
1993: E Nimmesgern; F Ulrich Hartl
ATP-dependent protein refolding activity in reticulocyte lysate. Evidence for the participation of different chaperone components.
FEBS letters 1993;331(1-2):25-30.
1993: Manajit Hayer-Hartl; F Ulrich Hartl
A comment on: 'The aromatic amino acid content of the bacterial chaperone protein groEL (cpn60): evidence for the presence of a single tryptophan', by N.C. Price, S.M. Kelly, S. Wood and A. auf der Mauer (1991) FEBS Lett. 292, 9-12.
FEBS letters 1993;320(1):83-4; discussion 85.
1993: J P Hendrick; F Ulrich Hartl
Molecular chaperone functions of heat-shock proteins.
Annual review of biochemistry 1993;62():349-84.
1992: Judith Frydman; E Nimmesgern; Hediye Erdjument-Bromage; J S Wall; Paul Tempst; F Ulrich Hartl
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.
The EMBO journal 1992;11(13):4767-78.
1992: T Langer; G Pfeifer; J Martin; W Baumeister; F Ulrich Hartl
Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.
The EMBO journal 1992;11(13):4757-65.
1992: J Martin; A L Horwich; F Ulrich Hartl
Prevention of protein denaturation under heat stress by the chaperonin Hsp60.
Science (New York, N.Y.) 1992;258(5084):995-8.
1992: T Langer; C Lu; H Echols; J Flanagan; M K Hayer; F Ulrich Hartl
Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding.
Nature 1992;356(6371):683-9.
1992: F Ulrich Hartl; J Martin; W Neupert
Protein folding in the cell: the role of molecular chaperones Hsp70 and Hsp60.
Annual review of biophysics and biomolecular structure 1992;21():293-322.
1991: J D Trent; E Nimmesgern; J S Wall; F Ulrich Hartl; A L Horwich
A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1.
Nature 1991;354(6353):490-3.