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Ulrich Hartl

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Physiology

Protein Folding

Chemicals & Drugs

Phenomena

Protein Binding

Living Beings

Escherichia coli

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

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Co-Publications
Name
25
Hayer-Hartl, Manajit
14
Young, Jason
10
Siegers, Katja
10
Chang, Hung-Chun
8
Bracher, Andreas
7
Georgopoulos, Costa
6
Barral, José
6
Broadley, Sarah
6
Moarefi, Ismail
5
Tang, Yun-Chi
5
Rein, Theo
5
Robinson, Carol
5
Dobson, Christopher
5
Etchells, Stephanie
5
Frydman, Judith

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Publications

TOP 3
Broadley Sarah A; Hartl F Ulrich
The role of molecular chaperones in human misfolding diseases.
Hartl F Ulrich; Hayer-Hartl Manajit
Converging concepts of protein folding in vitro and in vivo.
Gamerdinger Martin; Hajieva Parvana; Kaya A Murat; Wolfrum Uwe; Hartl F Ulrich; Behl Christian
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.

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All Publications

2009: Broadley Sarah A; Hartl F Ulrich
The role of molecular chaperones in human misfolding diseases.
FEBS letters 2009;583(16):2647-53.
2009: Hartl F Ulrich; Hayer-Hartl Manajit
Converging concepts of protein folding in vitro and in vivo.
Nature structural & molecular biology 2009;16(6):574-81.
2009: Gamerdinger Martin; Hajieva Parvana; Kaya A Murat; Wolfrum Uwe; Hartl F Ulrich; Behl Christian
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
The EMBO journal 2009;28(7):889-901.
2009: Brandt Florian; Etchells Stephanie A; Ortiz Julio O; Elcock Adrian H; Hartl F Ulrich; Baumeister Wolfgang
The native 3D organization of bacterial polysomes.
Cell 2009;136(2):261-71.
2008: Polier Sigrun; Dragovic Zdravko; Hartl F Ulrich; Bracher Andreas
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
Cell 2008;133(6):1068-79.
2008: Tang Yun-Chi; Chang Hung-Chun; Chakraborty Kausik; Hartl F Ulrich; Hayer-Hartl Manajit
Essential role of the chaperonin folding compartment in vivo.
The EMBO journal 2008;27(10):1458-68.
2008: Sharma Shruti; Chakraborty Kausik; Müller Barbara K; Astola Nagore; Tang Yun-Chi; Lamb Don C; Hayer-Hartl Manajit; Hartl F Ulrich
Monitoring protein conformation along the pathway of chaperonin-assisted folding.
Cell 2008;133(1):142-53.
2008: Siegers Katja; Bölter Bettina; Schwarz Juliane P; Böttcher Ulrike M K; Guha Suranjana; Hartl F Ulrich
TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes.
The EMBO journal 2008;27(1):301.
2008: Broadley Sarah A; Hartl F Ulrich
Mitochondrial stress signaling: a pathway unfolds.
Trends in cell biology 2008;18(1):1-4.
2008: Ishihama Yasushi; Schmidt Thorsten; Rappsilber Juri; Mann Matthias; Hartl F Ulrich; Kerner Michael J; Frishman Dmitrij
Protein abundance profiling of the Escherichia coli cytosol.
BMC genomics 2008;9():102.
2007: Grallath Silke; Schwarz Juliane P; Bottcher Ulrike M K; Bracher Andreas; Hartl F Ulrich; Siegers Katja
L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle.
EMBO reports 2007;8(11):1086.
2007: Saschenbrecker Sandra; Bracher Andreas; Rao Karnam Vasudeva; Rao Bharathi Vasudeva; Hartl F Ulrich; Hayer-Hartl Manajit
Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco.
Cell 2007;129(6):1189-200.
2007: Haacke Annette; Hartl F Ulrich; Breuer Peter
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
The Journal of biological chemistry 2007;282(26):18851-6.
2007: Lakshmipathy Sathish K; Tomic Sladjana; Kaiser Christian M; Chang Hung-Chun; Genevaux Pierre; Georgopoulos Costa; Barral José M; Johnson Arthur E; Hartl F Ulrich; Etchells Stephanie A
Identification of nascent chain interaction sites on trigger factor.
The Journal of biological chemistry 2007;282(16):12186-93.
2007: Schiffer Niclas W; Broadley Sarah A; Hirschberger Thomas; Tavan Paul; Kretzschmar Hans A; Giese Armin; Haass Christian; Hartl F Ulrich; Schmid Bettina
Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model.
The Journal of biological chemistry 2007;282(12):9195-203.
2007: Chang Hung-Chun; Tang Yun-Chi; Hayer-Hartl Manajit; Hartl F Ulrich
SnapShot: molecular chaperones, Part I.
Cell 2007;128(1):212.
2007: Tang Yun-Chi; Chang Hung-Chun; Hayer-Hartl Manajit; Hartl F Ulrich
SnapShot: molecular chaperones, Part II.
Cell 2007;128(2):412.
2006: Dragovic Zdravko; Shomura Yasuhito; Tzvetkov Nikolay; Hartl F Ulrich; Bracher Andreas
Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p.
Biological chemistry 2006;387(12):1593-600.
2006: Kaiser Christian M; Chang Hung-Chun; Agashe Vishwas R; Lakshmipathy Sathish K; Etchells Stephanie A; Hayer-Hartl Manajit; Hartl F Ulrich; Barral José M
Real-time observation of trigger factor function on translating ribosomes.
Nature 2006;444(7118):455-60.
2006: Fonseca Rosalina; Vabulas Ramunas M; Hartl F Ulrich; Bonhoeffer Tobias; Nägerl U Valentin
A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP.
Neuron 2006;52(2):239-45.
2006: Behrends Christian; Langer Carola A; Boteva Raina; Böttcher Ulrike M; Stemp Markus J; Schaffar Gregor; Rao Bharathi Vasudeva; Giese Armin; Kretzschmar Hans; Siegers Katja; Hartl F Ulrich
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.
Molecular cell 2006;23(6):887-97.
2006: Bracher Andreas; Hartl F Ulrich
Hsp90 structure: when two ends meet.
Nature structural & molecular biology 2006;13(6):478-80.
2006: Tang Yun-Chi; Chang Hung-Chun; Roeben Annette; Wischnewski Dirk; Wischnewski Nadine; Kerner Michael J; Hartl F Ulrich; Hayer-Hartl Manajit
Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein.
Cell 2006;125(5):903-14.
2006: Dragovic Zdravko; Broadley Sarah A; Shomura Yasuhito; Bracher Andreas; Hartl F Ulrich
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s.
The EMBO journal 2006;25(11):2519-28.
2006: Roeben Annette; Kofler Christine; Nagy István; Nickell Stephan; Hartl F Ulrich; Bracher Andreas
Crystal structure of an archaeal actin homolog.
Journal of molecular biology 2006;358(1):145-56.
2006: Haacke Annette; Broadley Sarah A; Boteva Raina; Tzvetkov Nikolay; Hartl F Ulrich; Breuer Peter
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.
Human molecular genetics 2006;15(4):555-68.
2006: Tomic Sladjana; Johnson Arthur E; Hartl F Ulrich; Etchells Stephanie A
Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains.
FEBS letters 2006;580(1):72-6.
2006: Grallath Silke; Schwarz Juliane P; Böttcher Ulrike M K; Bracher Andreas; Hartl F Ulrich; Siegers Katja
L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle.
EMBO reports 2006;7(1):78-84.
2005: Vabulas Ramunas M; Hartl F Ulrich
Protein synthesis upon acute nutrient restriction relies on proteasome function.
Science (New York, N.Y.) 2005;310(5756):1960-3.
2005: Chang Hung-Chun; Kaiser Christian M; Hartl F Ulrich; Barral José M
De novo folding of GFP fusion proteins: high efficiency in eukaryotes but not in bacteria.
Journal of molecular biology 2005;353(2):397-409.
2005: Hartl F Ulrich
Paper of the year 2004: award to Yin Wang and Iris Lorenzi.
Biological chemistry 2005;386(9):815.
2005: Stemp Markus J; Guha Suranjana; Hartl F Ulrich; Barral José M
Efficient production of native actin upon translation in a bacterial lysate supplemented with the eukaryotic chaperonin TRiC.
Biological chemistry 2005;386(8):753-7.
2005: Kerner Michael J; Naylor Dean J; Ishihama Yasushi; Maier Tobias; Chang Hung-Chun; Stines Anna P; Georgopoulos Costa; Frishman Dmitrij; Hayer-Hartl Manajit; Mann Matthias; Hartl F Ulrich
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.
Cell 2005;122(2):209-20.
2005: Bertsch Uwe; Winklhofer Konstanze F; Hirschberger Thomas; Bieschke Jan; Weber Petra; Hartl F Ulrich; Tavan Paul; Tatzelt Jörg; Kretzschmar Hans A; Giese Armin
Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.
Journal of virology 2005;79(12):7785-91.
2005: Bracher Andreas; Hartl F Ulrich
Towards a complete structure of Hsp90.
Structure (London, England : 1993) 2005;13(4):501-2.
2005: Shomura Yasuhito; Dragovic Zdravko; Chang Hung-Chun; Tzvetkov Nikolay; Young Jason C; Brodsky Jeffrey L; Guerriero Vince; Hartl F Ulrich; Bracher Andreas
Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.
Molecular cell 2005;17(3):367-79.
2004: Young Jason C; Agashe Vishwas R; Siegers Katja; Hartl F Ulrich
Pathways of chaperone-mediated protein folding in the cytosol.
Nature reviews. Molecular cell biology 2004;5(10):781-91.
2004: Schaffar Gregor; Breuer Peter; Boteva Raina; Behrends Christian; Tzvetkov Nikolay; Strippel Nadine; Sakahira Hideki; Siegers Katja; Hayer-Hartl Manajit; Hartl F Ulrich
Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.
Molecular cell 2004;15(1):95-105.
2004: Etchells Stephanie A; Hartl F Ulrich
The dynamic tunnel.
Nature structural & molecular biology 2004;11(5):391-2.
2004: Agashe Vishwas R; Guha Suranjana; Chang Hung-Chun; Genevaux Pierre; Hayer-Hartl Manajit; Stemp Markus; Georgopoulos Costa; Hartl F Ulrich; Barral José M
Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed.
Cell 2004;117(2):199-209.
2004: Barral José M; Broadley Sarah A; Schaffar Gregor; Hartl F Ulrich
Roles of molecular chaperones in protein misfolding diseases.
Seminars in cell & developmental biology 2004;15(1):17-29.
2004: Wochnik Gabriela M; Young Jason C; Schmidt Ulrike; Holsboer Florian; Hartl F Ulrich; Rein Theo
Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.
FEBS letters 2004;560(1-3):35-8.
2004: Genevaux Pierre; Keppel France; Schwager Françoise; Langendijk-Genevaux Petra S; Hartl F Ulrich; Georgopoulos Costa
In vivo analysis of the overlapping functions of DnaK and trigger factor.
EMBO reports 2004;5(2):195-200.
2004: Figueiredo Luis; Klunker Daniel; Ang Debbie; Naylor Dean J; Kerner Michael J; Georgopoulos Costa; Hartl F Ulrich; Hayer-Hartl Manajit
Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation.
The Journal of biological chemistry 2004;279(2):1090-9.
2003: Siegers Katja; Bölter Bettina; Schwarz Juliane P; Böttcher Ulrike M K; Guha Suranjana; Hartl F Ulrich
TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes.
The EMBO journal 2003;22(19):5230-40.
2003: Rosenhagen Marcus C; Soti Csaba; Schmidt Ulrike; Wochnik Gabriela M; Hartl F Ulrich; Holsboer Florian; Young Jason C; Rein Theo
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):1991-2001.
2003: Hartl F Ulrich
Paper of the Year 2002: Award to Cordelia Schiene-Fischer.
Biological chemistry 2003;384(9):1253-4.
2003: Klunker Daniel; Haas Bernd; Hirtreiter Angela; Figueiredo Luis; Naylor Dean J; Pfeifer Günter; Müller Volker; Deppenmeier Uwe; Gottschalk Gerhard; Hartl F Ulrich; Hayer-Hartl Manajit
Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei.
The Journal of biological chemistry 2003;278(35):33256-67.
2003: Brychzy Alexander; Rein Theo; Winklhofer Konstanze F; Hartl F Ulrich; Young Jason C; Obermann Wolfgang M J
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
The EMBO journal 2003;22(14):3613-23.
2003: Young Jason C; Hartl F Ulrich
A stress sensor for the bacterial periplasm.
Cell 2003;113(1):1-2.
2003: Schmidt Ulrike; Wochnik Gabriela M; Rosenhagen Marcus C; Young Jason C; Hartl F Ulrich; Holsboer Florian; Rein Theo
Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor.
The Journal of biological chemistry 2003;278(7):4926-31.
2003: Young Jason C; Hoogenraad Nicholas J; Hartl F Ulrich
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.
Cell 2003;112(1):41-50.
2003: Dou Fei; Netzer William J; Tanemura Kentaro; Li Feng; Hartl F Ulrich; Takashima Akihiko; Gouras Gunnar K; Greengard Paul; Xu Huaxi
Chaperones increase association of tau protein with microtubules.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):721-6.
2002: Sakahira Hideki; Breuer Peter; Hayer-Hartl Manajit K; Hartl F Ulrich
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99 Suppl 4():16412-8.
2002: Becker Thalia; Hartl F-Ulrich; Wieland Felix
CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes.
The Journal of cell biology 2002;158(7):1277-85.
2002: Young Jason C; Hartl F Ulrich
Chaperones and transcriptional regulation by nuclear receptors.
Nature structural biology 2002;9(9):640-2.
2002: Sondermann Holger; Ho Albert K; Listenberger Laura L; Siegers Katja; Moarefi Ismail; Wente Susan R; Hartl F-Ulrich; Young Jason C
Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae.
The Journal of biological chemistry 2002;277(36):33220-7.
2002: Brinker Achim; Scheufler Clemens; Von Der Mulbe Florian; Fleckenstein Burkhard; Herrmann Christian; Jung Gunther; Moarefi Ismail; Hartl F Ulrich
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes.
The Journal of biological chemistry 2002;277(22):19265-75.
2002: Hartl F Ulrich; Hayer-Hartl Manajit
Molecular chaperones in the cytosol: from nascent chain to folded protein.
Science (New York, N.Y.) 2002;295(5561):1852-8.
2002: Barral Jose M; Hutagalung Alex H; Brinker Achim; Hartl F Ulrich; Epstein Henry F
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin.
Science (New York, N.Y.) 2002;295(5555):669-71.
2001: Stöckel J; Hartl F U
Chaperonin-mediated de novo generation of prion protein aggregates.
Journal of molecular biology 2001;313(4):861-72.
2001: Brinker A; Pfeifer G; Kerner M J; Naylor D J; Hartl F U; Hayer-Hartl M
Dual function of protein confinement in chaperonin-assisted protein folding.
Cell 2001;107(2):223-33.
2001: Winklhofer K F; Hartl F U; Tatzelt J
A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds.
FEBS letters 2001;503(1):41-5.
2001: Young J C; Moarefi I; Hartl F U
Hsp90: a specialized but essential protein-folding tool.
The Journal of cell biology 2001;154(2):267-73.
2001: Sittler A; Lurz R; Lueder G; Priller J; Lehrach H; Hayer-Hartl M K; Hartl F U; Wanker E E
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
Human molecular genetics 2001;10(12):1307-15.
2001: Rosenhagen M C; Young J C; Wochnik G M; Herr A S; Schmidt U; Hartl F U; Holsboer F; Rein T
Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.
Biological chemistry 2001;382(3):499-504.
2001: Sondermann H; Scheufler C; Schneider C; Hohfeld J; Hartl F U; Moarefi I
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.
Science (New York, N.Y.) 2001;291(5508):1553-7.
2001: Naylor D J; Hartl F U
Contribution of molecular chaperones to protein folding in the cytoplasm of prokaryotic and eukaryotic cells.
Biochemical Society symposium 2001;(68):45-68.
2000: Sondermann H; Becker T; Mayhew M; Wieland F; Hartl F U
Characterization of a receptor for heat shock protein 70 on macrophages and monocytes.
Biological chemistry 2000;381(12):1165-74.
2000: Fändrich M; Tito M A; Leroux M R; Rostom A A; Hartl F U; Dobson C M; Robinson C V
Observation of the noncovalent assembly and disassembly pathways of the chaperone complex MtGimC by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14151-5.
2000: Siegert R; Leroux M R; Scheufler C; Hartl F U; Moarefi I
Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins.
Cell 2000;103(4):621-32.
2000: Young J C; Hartl F U
Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.
The EMBO journal 2000;19(21):5930-40.
2000: Muchowski P J; Schaffar G; Sittler A; Wanker E E; Hayer-Hartl M K; Hartl F U
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7841-6.
2000: Rostom A A; Fucini P; Benjamin D R; Juenemann R; Nierhaus K H; Hartl F U; Dobson C M; Robinson C V
Detection and selective dissociation of intact ribosomes in a mass spectrometer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5185-90.
2000: Scheufler C; Brinker A; Bourenkov G; Pegoraro S; Moroder L; Bartunik H; Hartl F U; Moarefi I
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine.
Cell 2000;101(2):199-210.
2000: Leroux M R; Hartl F U
Protein folding: versatility of the cytosolic chaperonin TRiC/CCT.
Current biology : CB 2000;10(7):R260-4.
2000: Moroi Y; Mayhew M; Trcka J; Hoe M H; Takechi Y; Hartl F U; Rothman J E; Houghton A N
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3485-90.
2000: Agashe V R; Hartl F U
Roles of molecular chaperones in cytoplasmic protein folding.
Seminars in cell & developmental biology 2000;11(1):15-25.
1999: Leroux M R; Fändrich M; Klunker D; Siegers K; Lupas A N; Brown J R; Schiebel E; Dobson C M; Hartl F U
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin.
The EMBO journal 1999;18(23):6730-43.
1999: Houry W A; Frishman D; Eckerskorn C; Lottspeich F; Hartl F U
Identification of in vivo substrates of the chaperonin GroEL.
Nature 1999;402(6758):147-54.
1999: Tector M; Hartl F U
An unstable transmembrane segment in the cystic fibrosis transmembrane conductance regulator.
The EMBO journal 1999;18(22):6290-8.
1999: Teter S A; Houry W A; Ang D; Tradler T; Rockabrand D; Fischer G; Blum P; Georgopoulos C; Hartl F U
Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains.
Cell 1999;97(6):755-65.
1999: Hayer-Hartl M K; Ewalt K L; Hartl F U
On the role of symmetrical and asymmetrical chaperonin complexes in assisted protein folding.
Biological chemistry 1999;380(5):531-40.
1999: Siegers K; Waldmann T; Leroux M R; Grein K; Shevchenko A; Schiebel E; Hartl F U
Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system.
The EMBO journal 1999;18(1):75-84.
1998: Obermann W M; Sondermann H; Russo A A; Pavletich N P; Hartl F U
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
The Journal of cell biology 1998;143(4):901-10.
1998: Weber F; Keppel F; Georgopoulos C; Hayer-Hartl M K; Hartl F U
The oligomeric structure of GroEL/GroES is required for biologically significant chaperonin function in protein folding.
Nature structural biology 1998;5(11):977-85.
1998: Young J C; Obermann W M; Hartl F U
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.
The Journal of biological chemistry 1998;273(29):18007-10.
1998: Benjamin D R; Robinson C V; Hendrick J P; Hartl F U; Dobson C M
Mass spectrometry of ribosomes and ribosomal subunits.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7391-5.
1998: Heyrovská N; Frydman J; Höhfeld J; Hartl F U
Directionality of polypeptide transfer in the mitochondrial pathway of chaperone-mediated protein folding.
Biological chemistry 1998;379(3):301-9.
1998: Netzer W J; Hartl F U
Protein folding in the cytosol: chaperonin-dependent and -independent mechanisms.
Trends in biochemical sciences 1998;23(2):68-73.
1997: Young J C; Schneider C; Hartl F U
In vitro evidence that hsp90 contains two independent chaperone sites.
FEBS letters 1997;418(1-2):139-43.
1997: Ewalt K L; Hendrick J P; Houry W A; Hartl F U
In vivo observation of polypeptide flux through the bacterial chaperonin system.
Cell 1997;90(3):491-500.
1997: Netzer W J; Hartl F U
Recombination of protein domains facilitated by co-translational folding in eukaryotes.
Nature 1997;388(6640):343-9.
1996: Gross M; Robinson C V; Mayhew M; Hartl F U; Radford S E
Significant hydrogen exchange protection in GroEL-bound DHFR is maintained during iterative rounds of substrate cycling.
Protein science : a publication of the Protein Society 1996;5(12):2506-13.
1996: Schneider C; Sepp-Lorenzino L; Nimmesgern E; Ouerfelli O; Danishefsky S; Rosen N; Hartl F U
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14536-41.
1996: Schneider C; Hartl F U
Hats off to the tricorn protease.
Science (New York, N.Y.) 1996;274(5291):1323-4.
1996: Hayer-Hartl M K; Weber F; Hartl F U
Mechanism of chaperonin action: GroES binding and release can drive GroEL-mediated protein folding in the absence of ATP hydrolysis.
The EMBO journal 1996;15(22):6111-21.
1996: Minami Y; Höhfeld J; Ohtsuka K; Hartl F U
Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40.
The Journal of biological chemistry 1996;271(32):19617-24.
1996: Qian Y Q; Patel D; Hartl F U; McColl D J
Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain.
Journal of molecular biology 1996;260(2):224-35.
1996: Hartl F U
Molecular chaperones in cellular protein folding.
Nature 1996;381(6583):571-9.
1996: Frydman J; Hartl F U
Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms.
Science (New York, N.Y.) 1996;272(5267):1497-502.
1996: Mayhew M; da Silva A C; Martin J; Erdjument-Bromage H; Tempst P; Hartl F U
Protein folding in the central cavity of the GroEL-GroES chaperonin complex.
Nature 1996;379(6564):420-6.
1996: Szabo A; Korszun R; Hartl F U; Flanagan J
A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.
The EMBO journal 1996;15(2):408-17.
1996: Mayhew M; Hartl F U
Lord of the rings: GroES structure.
Science (New York, N.Y.) 1996;271(5246):161-2.
1995: Hendrick J P; Hartl F U
The role of molecular chaperones in protein folding.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(15):1559-69.
1995: Höhfeld J; Minami Y; Hartl F U
Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle.
Cell 1995;83(4):589-98.
1995: Hayer-Hartl M K; Martin J; Hartl F U
Asymmetrical interaction of GroEL and GroES in the ATPase cycle of assisted protein folding.
Science (New York, N.Y.) 1995;269(5225):836-41.
1995: Engel A; Hayer-Hartl M K; Goldie K N; Pfeifer G; Hegerl R; Müller S; da Silva A C; Baumeister W; Hartl F U
Functional significance of symmetrical versus asymmetrical GroEL-GroES chaperonin complexes.
Science (New York, N.Y.) 1995;269(5225):832-6.
1995: Hlodan R; Tempst P; Hartl F U
Binding of defined regions of a polypeptide to GroEL and its implications for chaperonin-mediated protein folding.
Nature structural biology 1995;2(7):587-95.
1995: Hartl F U
Principles of chaperone-mediated protein folding.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;348(1323):107-12.
1995: Waldmann T; Nimmesgern E; Nitsch M; Peters J; Pfeifer G; Müller S; Kellermann J; Engel A; Hartl F U; Baumeister W
The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC.
European journal of biochemistry / FEBS 1995;227(3):848-56.
1995: Hartl F U; Martin J
Molecular chaperones in cellular protein folding.
Current opinion in structural biology 1995;5(1):92-102.
1994: Robinson C V; Gross M; Eyles S J; Ewbank J J; Mayhew M; Hartl F U; Dobson C M; Radford S E
Conformation of GroEL-bound alpha-lactalbumin probed by mass spectrometry.
Nature 1994;372(6507):646-51.
1994: Szabo A; Langer T; Schröder H; Flanagan J; Bukau B; Hartl F U
The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10345-9.
1994: Martin J; Goldie K N; Engel A; Hartl F U
Topology of the morphological domains of the chaperonin GroEL visualized by immuno-electron microscopy.
Biological chemistry Hoppe-Seyler 1994;375(9):635-9.
1994: Höhfeld J; Hartl F U
Post-translational protein import and folding.
Current opinion in cell biology 1994;6(4):499-509.
1994: Li W Z; Lin P; Frydman J; Boal T R; Cardillo T S; Richard L M; Toth D; Lichtman M A; Hartl F U; Sherman F
Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast.
The Journal of biological chemistry 1994;269(28):18616-22.
1994: Frydman J; Nimmesgern E; Ohtsuka K; Hartl F U
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones.
Nature 1994;370(6485):111-7.
1994: Hayer-Hartl M K; Ewbank J J; Creighton T E; Hartl F U
Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin.
The EMBO journal 1994;13(13):3192-202.
1994: Höhfeld J; Hartl F U
Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria.
The Journal of cell biology 1994;126(2):305-15.
1994: Hartl F U; Hlodan R; Langer T
Molecular chaperones in protein folding: the art of avoiding sticky situations.
Trends in biochemical sciences 1994;19(1):20-5.
1993: Martin J; Hartl F U
Protein folding in the cell: molecular chaperones pave the way.
Structure (London, England : 1993) 1993;1(3):161-4.
1993: Hendrick J P; Langer T; Davis T A; Hartl F U; Wiedmann M
Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10216-20.
1993: Martin J; Geromanos S; Tempst P; Hartl F U
Identification of nucleotide-binding regions in the chaperonin proteins GroEL and GroES.
Nature 1993;366(6452):279-82.
1993: Martin J; Mayhew M; Langer T; Hartl F U
The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding.
Nature 1993;366(6452):228-33.
1993: Nimmesgern E; Hartl F U
ATP-dependent protein refolding activity in reticulocyte lysate. Evidence for the participation of different chaperone components.
FEBS letters 1993;331(1-2):25-30.
1993: Hayer-Hartl M K; Hartl F U
A comment on: 'The aromatic amino acid content of the bacterial chaperone protein groEL (cpn60): evidence for the presence of a single tryptophan', by N.C. Price, S.M. Kelly, S. Wood and A. auf der Mauer (1991) FEBS Lett. 292, 9-12.
FEBS letters 1993;320(1):83-4; discussion 85.
1993: Hendrick J P; Hartl F U
Molecular chaperone functions of heat-shock proteins.
Annual review of biochemistry 1993;62():349-84.
1992: Frydman J; Nimmesgern E; Erdjument-Bromage H; Wall J S; Tempst P; Hartl F U
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.
The EMBO journal 1992;11(13):4767-78.
1992: Langer T; Pfeifer G; Martin J; Baumeister W; Hartl F U
Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.
The EMBO journal 1992;11(13):4757-65.
1992: Martin J; Horwich A L; Hartl F U
Prevention of protein denaturation under heat stress by the chaperonin Hsp60.
Science (New York, N.Y.) 1992;258(5084):995-8.
1992: Langer T; Lu C; Echols H; Flanagan J; Hayer M K; Hartl F U
Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding.
Nature 1992;356(6371):683-9.
1992: Hartl F U; Martin J; Neupert W
Protein folding in the cell: the role of molecular chaperones Hsp70 and Hsp60.
Annual review of biophysics and biomolecular structure 1992;21():293-322.
1991: Trent J D; Nimmesgern E; Wall J S; Hartl F U; Horwich A L
A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1.
Nature 1991;354(6353):490-3.

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