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John Hartley

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

DNA Damage

Anatomy

Physiology

DNA Repair

Concepts & Ideas

Phenomena

Procedures

Antitumor Drug Screening Assays

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Co-Publications
Name
40
Lee, Moses
20
Souhami, Robert
15
Hochhauser, Daniel
14
Thurston, David
13
McHugh, Peter
12
Grimaldi, Keith
12
Kiakos, Konstantinos
11
O'Hare, Caroline
10
Wilson, David W.
9
kluza, jerome
9
Nguyen, Binh
9
Spanswick, Victoria
9
Jenkins, Terence
9
Kelland, Lloyd
8
Howard, Philip

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Publications

TOP 3
Boone Julien J M; Bhosle Jaishree; Tilby Mike J; Hartley John A; Hochhauser Daniel
Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents.
Westrate Laura; Mackay Hilary; Brown Toni; Nguyen Binh; Kluza Jerome; Wilson W David; Lee Moses; Hartley John A
Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.
Lajiness Jamie; Sielaff Alan; Mackay Hilary; Brown Toni; Kluza Jerome; Nguyen Binh; Wilson W David; Lee Moses; Hartley John A
Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature.

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All Publications

2009: Boone Julien J M; Bhosle Jaishree; Tilby Mike J; Hartley John A; Hochhauser Daniel
Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents.
Molecular cancer therapeutics 2009;8(11):3015-23.
2009: Westrate Laura; Mackay Hilary; Brown Toni; Nguyen Binh; Kluza Jerome; Wilson W David; Lee Moses; Hartley John A
Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.
Biochemistry 2009;48(24):5679-88.
2009: Lajiness Jamie; Sielaff Alan; Mackay Hilary; Brown Toni; Kluza Jerome; Nguyen Binh; Wilson W David; Lee Moses; Hartley John A
Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2009;5(3):216-26.
2009: Hochhauser Daniel; Meyer Timothy; Spanswick Victoria J; Wu Jenny; Clingen Peter H; Loadman Paul; Cobb Margaret; Gumbrell Lindsey; Begent Richard H; Hartley John A; Jodrell Duncan
Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):2140-7.
2008: Mackay Hilary; Brown Toni; Uthe Peter B; Westrate Laura; Sielaff Alan; Jones Justin; Lajiness James P; Kluza Jerome; O'Hare Caroline; Nguyen Binh; Davis Zach; Bruce Chrystal; Wilson W David; Hartley John A; Lee Moses
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
Bioorganic & medicinal chemistry 2008;16(20):9145-53.
2008: Clingen P H; Wu J Y-H; Miller J; Mistry N; Chin F; Wynne P; Prise K M; Hartley J A
Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.
Biochemical pharmacology 2008;76(1):19-27.
2008: Kotecha Minal; Kluza Jerome; Wells Geoff; O'Hare C Caroline; Forni Claudia; Mantovani Roberto; Howard Philip W; Morris Peter; Thurston David E; Hartley John A; Hochhauser Daniel
Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78.
Molecular cancer therapeutics 2008;7(5):1319-28.
2008: Brown Toni; Mackay Hilary; Turlington Mark; Sutterfield Arden; Smith Traci; Sielaff Alan; Westrate Laura; Bruce Chrystal; Kluza Jerome; O'Hare Caroline; Nguyen Binh; Wilson W David; Hartley John A; Lee Moses
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm.
Bioorganic & medicinal chemistry 2008;16(9):5266-76.
2008: Wells Geoffrey; Suggitt Marie; Coffils Marissa; Baig Mirza A H; Howard Philip W; Loadman Paul M; Hartley John A; Jenkins Terence C; Thurston David E
Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.
Bioorganic & medicinal chemistry letters 2008;18(6):2147-51.
2008: Tiberghien Arnaud C; Evans David A; Kiakos Konstantinos; Martin Christopher R H; Hartley John A; Thurston David E; Howard Philip W
An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
Bioorganic & medicinal chemistry letters 2008;18(6):2073-7.
2008: Hazrati Ali; Ramis-Castelltort Marc; Sarkar Sovan; Barber Louise J; Schofield Christopher J; Hartley John A; McHugh Peter J
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.
DNA repair 2008;7(2):230-8.
2008: Mackay Hilary; Brown Toni; Sexton Jim S; Kotecha Minal; Nguyen Binh; Wilson W David; Kluza Jerome; Savic Boris; O'Hare Caroline; Hochhauser Daniel; Lee Moses; Hartley John A
Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.
Bioorganic & medicinal chemistry 2008;16(4):2093-102.
2007: Allen Olivia R; Gott Andrew L; Hartley John A; Hartley Janet M; Knox Richard J; McGowan Patrick C
Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs.
Dalton transactions (Cambridge, England : 2003) 2007;(43):5082-90.
2007: Kiakos Konstantinos; Sato Atsushi; Asao Tetsuji; McHugh Peter J; Lee Moses; Hartley John A
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
Molecular cancer therapeutics 2007;6(10):2708-18.
2007: O'Hare C Caroline; Uthe Peter; Mackay Hilary; Blackmon Kevin; Jones Justin; Brown Toni; Nguyen Binh; Wilson W David; Lee Moses; Hartley John A
Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
Biochemistry 2007;46(42):11661-70.
2007: Wynne P; Newton C; Ledermann J A; Olaitan A; Mould T A; Hartley J A
Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy.
British journal of cancer 2007;97(7):927-33.
2007: Rachid Zakaria; Brahimi Fouad; Qiu Qiyu; Williams Christopher; Hartley Janet M; Hartley John A; Jean-Claude Bertrand J
Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discovery of an unusual structure-activity relationship.
Journal of medicinal chemistry 2007;50(11):2605-8.
2007: Clingen Peter H; Arlett Colin F; Hartley John A; Parris Christopher N
Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links.
Experimental cell research 2007;313(4):753-60.
2007: Hochhauser Daniel; Kotecha Minal; O'hare Caroline; Morris Peter J; Hartley Janet M; Taherbhai Zarmeen; Harris Dorothy; Forni Claudia; Mantovani Roberto; Lee Moses; Hartley John A
Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide.
Molecular cancer therapeutics 2007;6(1):346-54.
2007: Brown Toni; Taherbhai Zarmeen; Sexton Jim; Sutterfield Arden; Turlington Mark; Jones Justin; Stallings Lindsay; Stewart Michelle; Buchmueller Karen; Mackay Hilary; O'hare Caroline; Kluza Jerome; Nguyen Binh; Wilson David; Lee Moses; Hartley John A
Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
Bioorganic & medicinal chemistry 2007;15(1):474-83.
2006: Le N Minh; Sielaff Alan M; Cooper Amanda J; Mackay Hilary; Brown Toni; Kotecha Minal; O'Hare Caroline; Hochhauser Daniel; Lee Moses; Hartley John A
Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells.
Bioorganic & medicinal chemistry letters 2006;16(24):6161-4.
2006: Pors Klaus; Shnyder Steven D; Teesdale-Spittle Paul H; Hartley John A; Zloh Mire; Searcey Mark; Patterson Laurence H
Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides.
Journal of medicinal chemistry 2006;49(24):7013-23.
2006: Buchmueller Karen L; Bailey Suzanna L; Matthews David A; Taherbhai Zarmeen T; Register Janna K; Davis Zachary S; Bruce Chrystal D; O'Hare Caroline; Hartley John A; Lee Moses
Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm.
Biochemistry 2006;45(45):13551-65.
2006: Mayer Astrid; Francis Roslyn J; Sharma Surinder K; Tolner Berend; Springer Caroline J; Martin Jan; Boxer Geoff M; Bell James; Green Alan J; Hartley John A; Cruickshank Clare; Wren Julie; Chester Kerry A; Begent Richard H J
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6509-16.
2006: Flores Lloyd V; Staples Andrew M; Mackay Hilary; Howard Cameron M; Uthe Peter B; Sexton Jim S; Buchmueller Karen L; Wilson W David; O'Hare Caroline; Kluza Jerome; Hochhauser Daniel; Hartley John A; Lee Moses
Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter.
Chembiochem : a European journal of chemical biology 2006;7(11):1722-9.
2006: Purnell Bethany; Sato Atsushi; O'kelley Amanda; Price Carly; Summerville Kaitlin; Hudson Stephen; O'hare Caroline; Kiakos Konstantinos; Asao Tetsuji; Lee Moses; Hartley John A
DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
Bioorganic & medicinal chemistry letters 2006;16(21):5677-81.
2006: Wells Geoff; Martin Christopher R H; Howard Philip W; Sands Zara A; Laughton Charles A; Tiberghien Arnaud; Woo Chi Kit; Masterson Luke A; Stephenson Marissa J; Hartley John A; Jenkins Terence C; Shnyder Steven D; Loadman Paul M; Waring Michael J; Thurston David E
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
Journal of medicinal chemistry 2006;49(18):5442-61.
2006: Arnould Stéphanie; Spanswick Victoria J; Macpherson Janet S; Hartley John A; Thurston David E; Jodrell Duncan I; Guichard Sylvie M
Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.
Molecular cancer therapeutics 2006;5(6):1602-9.
2006: McGurk Claire J; Cummings Michele; Köberle Beate; Hartley John A; Oliver R Timothy; Masters John R
Regulation of DNA repair gene expression in human cancer cell lines.
Journal of cellular biochemistry 2006;97(5):1121-36.
2006: Purnell Bethany; Lingerfelt Brian; Scott Adrienne; Townes Heather; Summerville Kaitlin; Hudson Stephen; Kiakos Konstantinos; Hartley John A; Lee Moses
Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2006;2(2):139-46.
2006: Friedmann Benjamin J; Caplin Martyn; Savic Boris; Shah Tahir; Lord Christopher J; Ashworth Alan; Hartley John A; Hochhauser Daniel
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Molecular cancer therapeutics 2006;5(2):209-18.
2006: Kluza Jérôme; Mazinghien Romain; Irwin Helen; Hartley John A; Bailly Christian
Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide.
Anti-cancer drugs 2006;17(2):155-64.
2006: Masterson Luke A; Spanswick Victoria J; Hartley John A; Begent Richard H; Howard Philip W; Thurston David E
Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
Bioorganic & medicinal chemistry letters 2006;16(2):252-6.
2005: Buchmueller Karen L; Taherbhai Zarmeen; Howard Cameron M; Bailey Suzanna L; Nguyen Binh; O'Hare Caroline; Hochhauser Daniel; Hartley John A; Wilson W David; Lee Moses
Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene.
Chembiochem : a European journal of chemical biology 2005;6(12):2305-11.
2005: Casely-Hayford Maxwell A; Pors Klaus; James Colin H; Patterson Laurence H; Hartley John A; Searcey Mark
Design and synthesis of a DNA-crosslinking azinomycin analogue.
Organic & biomolecular chemistry 2005;3(19):3585-9.
2005: Lo Soo; Tolner Berend; Taanman Jan-Willem; Cooper J Mark; Gu Mei; Hartley John A; Schapira Anthony H V; Hochhauser Daniel
Assessment of the significance of mitochondrial DNA damage by chemotherapeutic agents.
International journal of oncology 2005;27(2):337-44.
2005: Sato Atsushi; McNulty Luanne; Cox Kari; Kim Susan; Scott Adrienne; Daniell Kristen; Summerville Kaitlin; Price Carly; Hudson Stephen; Kiakos Konstantinos; Hartley John A; Asao Tetsuji; Lee Moses
A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
Journal of medicinal chemistry 2005;48(11):3903-18.
2005: Corrie P G; Shaw J; Spanswick V J; Sehmbi R; Jonson A; Mayer A; Bulusu R; Hartley J A; Cree I A
Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients.
British journal of cancer 2005;92(11):1997-2003.
2005: Price Carly A; Lingerfelt Brian M; Handl Heather L; Kiakos Konstantinos; Hartley John A; Lee Moses
Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole-imidazole polyamides.
Bioorganic & medicinal chemistry letters 2005;15(12):3151-6.
2005: Parker Laurie L; Anderson Fiona M; O'Hare C Caroline; Lacy Stephen M; Bingham John P; Robins David J; Hartley John A
Synthesis of novel DNA cross-linking antitumour agents based on polyazamacrocycles.
Bioorganic & medicinal chemistry 2005;13(7):2389-95.
2005: Martin Chris; Ellis Tom; McGurk Claire J; Jenkins Terence C; Hartley John A; Waring Michael J; Thurston David E
Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
Biochemistry 2005;44(11):4135-47.
2005: Barber Louise J; Ward Thomas A; Hartley John A; McHugh Peter J
DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase.
Molecular and cellular biology 2005;25(6):2297-309.
2005: Toth James L; Trzupek John D; Flores Lloyd V; Kiakos Konstantinos; Hartley John A; Pennington William T; Lee Moses
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2005;1(1):13-9.
2005: Daniell Kristen; Stewart Michelle; Madsen Erik; Le Minh; Handl Heather; Brooks Natalie; Kiakos Konstantinos; Hartley John A; Lee Moses
Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.
Bioorganic & medicinal chemistry letters 2005;15(1):177-80.
2005: Clingen Peter H; De Silva Inusha U; McHugh Peter J; Ghadessy Farid J; Tilby Michael J; Thurston David E; Hartley John A
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.
Nucleic acids research 2005;33(10):3283-91.
2004: Kupchinsky Stanley; Centioni Sara; Howard Tiffany; Trzupek John; Roller Shane; Carnahan Virginia; Townes Heather; Purnell Bethany; Price Carly; Handl Heather; Summerville Kaitlin; Johnson Kimberly; Toth James; Hudson Stephen; Kiakos Konstantinos; Hartley John A; Lee Moses
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
Bioorganic & medicinal chemistry 2004;12(23):6221-36.
2004: Parker Laurie L; Lacy Stephen M; Farrugia Louis J; Evans Cameron; Robins David J; O'Hare C Caroline; Hartley John A; Jaffar Mohammed; Stratford Ian J
A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs.
Journal of medicinal chemistry 2004;47(23):5683-9.
2004: Friedmann Benjamin; Caplin Martyn; Hartley John A; Hochhauser Daniel
Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839).
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6476-86.
2004: Henry James A; Le N Minh; Nguyen Binh; Howard Cameron M; Bailey Suzanna L; Horick Sarah M; Buchmueller Karen L; Kotecha Minal; Hochhauser Daniel; Hartley John A; Wilson W David; Lee Moses
Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
Biochemistry 2004;43(38):12249-57.
2004: Alley Michael C; Hollingshead Melinda G; Pacula-Cox Christine M; Waud William R; Hartley John A; Howard Philip W; Gregson Stephen J; Thurston David E; Sausville Edward A
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Cancer research 2004;64(18):6700-6.
2004: Hartley John A; Spanswick Victoria J; Brooks Natalie; Clingen Peter H; McHugh Peter J; Hochhauser Daniel; Pedley R Barbara; Kelland Lloyd R; Alley Michael C; Schultz Robert; Hollingshead Melinda G; Schweikart Karen M; Tomaszewski Joseph E; Sausville Edward A; Gregson Stephen J; Howard Philip W; Thurston David E
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Cancer research 2004;64(18):6693-9.
2004: Urbaniak Michael D; Bingham John P; Hartley John A; Woolfson Derek N; Caddick Stephen
Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin.
Journal of medicinal chemistry 2004;47(19):4710-5.
2004: Baraldi Pier Giovanni; Beria Italo; Cozzi Paolo; Geroni Cristina; Espinosa Antonio; Gallo Miguel A; Entrena Antonio; Bingham John P; Hartley John A; Romagnoli Romeo
Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies.
Bioorganic & medicinal chemistry 2004;12(14):3911-21.
2004: Pors Klaus; Paniwnyk Zennia; Ruparelia Ketan C; Teesdale-Spittle Paul H; Hartley John A; Kelland Lloyd R; Patterson Laurence H
Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.
Journal of medicinal chemistry 2004;47(7):1856-9.
2004: Gregson Stephen J; Howard Philip W; Gullick Darren R; Hamaguchi Anzu; Corcoran Kathryn E; Brooks Natalie A; Hartley John A; Jenkins Terence C; Patel Sejal; Guille Matthew J; Thurston David E
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Journal of medicinal chemistry 2004;47(5):1161-74.
2003: Smellie Melissa; Bose Deravander S; Thompson Andrew S; Jenkins Terence C; Hartley John A; Thurston David E
Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.
Biochemistry 2003;42(27):8232-9.
2003: Lambert Sarah; Mason Sarah J; Barber Louise J; Hartley John A; Pearce Jackie A; Carr Anthony M; McHugh Peter J
Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links.
Molecular and cellular biology 2003;23(13):4728-37.
2003: Urbaniak Michael D; Frost Lisa M; Bingham John P; Kelland Lloyd R; Hartley John A; Woolfson Derek N; Caddick Stephen
Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore.
Bioorganic & medicinal chemistry letters 2003;13(12):2025-7.
2002: Kiakos Konstantinos; Howard Tiffany T; Lee Moses; Hartley John A; McHugh Peter J
Saccharomyces cerevisiae RAD5 influences the excision repair of DNA minor groove adducts.
The Journal of biological chemistry 2002;277(46):44576-81.
2002: De Silva Inusha U; McHugh Peter J; Clingen Peter H; Hartley John A
Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin.
Nucleic acids research 2002;30(17):3848-56.
2002: Howard Tiffany T; Lingerfelt Brian M; Purnell Bethany L; Scott Adrienne E; Price Carly A; Townes Heather M; McNulty LuAnne; Handl Heather L; Summerville Kaitlin; Hudson Stephen J; Bowen J Phillip; Kiakos Konstantinos; Hartley John A; Lee Moses
Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
Bioorganic & medicinal chemistry 2002;10(9):2941-52.
2002: Baraldi Pier Giovanni; Romagnoli Romeo; Guadix Antonio Entrena; Pineda de las Infantas Maria Josè; Gallo Miguel Angel; Espinosa Antonio; Martinez Alberto; Bingham John P; Hartley John A
Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A.
Journal of medicinal chemistry 2002;45(17):3630-8.
2002: Toth James L; Price Carly A; Madsen Erik C; Handl Heather L; Hudson Stephen J; Hubbard Richard B; Bowen J Phillip; Kiakos Konstantinos; Hartley John A; Lee Moses
Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides.
Bioorganic & medicinal chemistry letters 2002;12(16):2245-8.
2002: Spanswick Victoria J; Craddock Charles; Sekhar Mallika; Mahendra Prem; Shankaranarayana Paneesha; Hughes R George; Hochhauser Daniel; Hartley John A
Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma.
Blood 2002;100(1):224-9.
2002: Baraldi Pier Giovanni; Romagnoli Romeo; Giovanna Pavani Maria; del Carmen Nunez Maria; Bingham John P; Hartley John A
Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity.
Bioorganic & medicinal chemistry 2002;10(5):1611-8.
2002: Grimaldi Keith A; McGurk Claire J; McHugh Peter J; Hartley John A
PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells.
Molecular biotechnology 2002;20(2):181-96.
2002: O'Hare C Caroline; Mack Darcy; Tandon Manju; Sharma Sanjay K; Lown J William; Kopka Mary L; Dickerson Richard E; Hartley John A
DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):72-7.
2002: Sierens J; Hartley J A; Campbell M J; Leathem A J C; Woodside J V
In vitro isoflavone supplementation reduces hydrogen peroxide-induced DNA damage in sperm.
Teratogenesis, carcinogenesis, and mutagenesis 2002;22(3):227-34.
2001: Wickremasinghe R G; Ganeshaguru K; Jones D T; Lindsay C; Spanswick V J; Hartley J A; Wadhwa M; Thorpe R; Hoffbrand A V; Prentice H G; Mehta A B
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells.
British journal of haematology 2001;114(3):608-15.
2001: McHugh P J; Spanswick V J; Hartley J A
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.
The lancet oncology 2001;2(8):483-90.
2001: Webley S D; Francis R J; Pedley R B; Sharma S K; Begent R H; Hartley J A; Hochhauser D
Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material.
British journal of cancer 2001;84(12):1671-6.
2001: Tolner B; Hartley J A; Hochhauser D
Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs.
Molecular pharmacology 2001;59(4):699-706.
2001: Gregson S J; Howard P W; Hartley J A; Brooks N A; Adams L J; Jenkins T C; Kelland L R; Thurston D E
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Journal of medicinal chemistry 2001;44(5):737-48.
2001: Sierens J; Hartley J A; Campbell M J; Leathem A J; Woodside J V
Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay.
Mutation research 2001;485(2):169-76.
2000: De Silva I U; McHugh P J; Clingen P H; Hartley J A
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells.
Molecular and cellular biology 2000;20(21):7980-90.
2000: Brooks N; McHugh P J; Lee M; Hartley J A
Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove.
Chemistry & biology 2000;7(9):659-68.
2000: McHugh P J; Sones W R; Hartley J A
Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae.
Molecular and cellular biology 2000;20(10):3425-33.
2000: Anderson F M; O'Hare C C; Hartley J A; Robins D J
Synthesis of new homochiral bispyrrolidines as potential DNA cross-linking antitumour agents.
Anti-cancer drug design 2000;15(2):119-26.
1999: Wilson S C; Howard P W; Forrow S M; Hartley J A; Adams L J; Jenkins T C; Kelland L R; Thurston D E
Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
Journal of medicinal chemistry 1999;42(20):4028-41.
1999: McHugh P J; Gill R D; Waters R; Hartley J A
Excision repair of nitrogen mustard-DNA adducts in Saccharomyces cerevisiae.
Nucleic acids research 1999;27(16):3259-66.
1999: Hartley J M; Spanswick V J; Gander M; Giacomini G; Whelan J; Souhami R L; Hartley J A
Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):507-12.
1999: Köberle B; Masters J R; Hartley J A; Wood R D
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
Current biology : CB 1999;9(5):273-6.
1999: Brooks N; McHugh P J; Lee M; Hartley J A
The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size.
Anti-cancer drug design 1999;14(1):11-8.
1999: Hartley J A; O'Hare C C; Baumgart J
DNA alkylation and interstrand cross-linking by treosulfan.
British journal of cancer 1999;79(2):264-6.
1999: Grimaldi K A; McAdam S R; Hartley J A
PCR-based assays for strand-specific measurement of DNA damage and repair. II. Single-strand ligation-PCR.
Methods in molecular biology (Clifton, N.J.) 1999;113():241-55.
1999: Grimaldi K A; Bingham J P; Hartley J A
PCR-based assays for strand-specific measurement of DNA damage and repair. I. Strand-specific quantitative PCR.
Methods in molecular biology (Clifton, N.J.) 1999;113():227-40.
1998: Sunters A; Grimaldi K A; Souhami R L; Hartley J A
Gene and human tumour cell line specific differencesin nitrogen mustard induced DNA alkylation and interstrand crosslinking frequencies.
Nucleic acids research 1998;26(24):5617-23.
1998: Henderson N D; Lacy S M; O'Hare C C; Hartley J A; McClean S; Wakelin L P; Kelland L R; Robins D J
Synthesis of new bifunctional compounds which selectively alkylate guanines in DNA.
Anti-cancer drug design 1998;13(7):749-68.
1998: McAdam S R; Knox R J; Hartley J A; Masters J R
KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl] mitomycin C): DNA interactions and drug uptake following serum activation.
Biochemical pharmacology 1998;55(11):1777-83.
1998: Holford J; Raynaud F; Murrer B A; Grimaldi K; Hartley J A; Abrams M; Kelland L R
Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473).
Anti-cancer drug design 1998;13(1):1-18.
1997: Brooks N; Lee M; Wright S R; Woo S; Centioni S; Hartley J A
Synthesis, DNA binding, cytotoxicity and sequence specificity of a series of imidazole-containing analogs of the benzoic acid mustard distamycin derivative tallimustine containing an alkylating group at the C-terminus.
Anti-cancer drug design 1997;12(7):591-606.
1997: Brooks N; Hartley J A; Simpson J E; Wright S R; Woo S; Centioni S; Fontaine M D; McIntyre T E; Lee M
Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: synthesis, DNA binding and cytotoxicity studies.
Bioorganic & medicinal chemistry 1997;5(8):1497-507.
1997: Wyatt M D; Lee M; Hartley J A
The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.
Nucleic acids research 1997;25(12):2359-64.
1997: Puvvada M S; Forrow S A; Hartley J A; Stephenson P; Gibson I; Jenkins T C; Thurston D E
Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines.
Biochemistry 1997;36(9):2478-84.
1997: Köberle B; Grimaldi K A; Sunters A; Hartley J A; Kelland L R; Masters J R
DNA repair capacity and cisplatin sensitivity of human testis tumour cells.
International journal of cancer. Journal international du cancer 1997;70(5):551-5.
1997: Masters J R; Know R J; Hartley J A; Kelland L R; Hendriks H R; Connors T
KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl]mitomycin C). A new mitomycin C analogue activated by serum.
Biochemical pharmacology 1997;53(3):279-85.
1997: Wyatt M D; Lee M; Hartley J A
Alkylation specificity for a series of distamycin analogues that tether chlorambucil.
Anti-cancer drug design 1997;12(1):49-60.
1997: Grimaldi K A; Hartley J A
PCR-based methods for detecting DNA damage and its repair at the subgene and single nucleotide levels in cells.
Methods in molecular biology (Clifton, N.J.) 1997;90():157-80.
1997: Hartley J A; Wyatt M D
Determination of the DNA sequence specificity of alkylation damage using cleavage-based assays.
Methods in molecular biology (Clifton, N.J.) 1997;90():147-56.
1996: Köberle B; Payne J; Grimaldi K A; Hartley J A; Masters J R
DNA repair in cisplatin-sensitive and resistant human cell lines measured in specific genes by quantitative polymerase chain reaction.
Biochemical pharmacology 1996;52(11):1729-34.
1996: Sunters A; Grimaldi K A; Souhami R L; Hartley J A
The use of alpha-DNA as an internal standard in the detection and quantitation of DNA damage in specific genes using Southern blotting.
Nucleic acids research 1996;24(12):2456-7.
1996: Bingham J P; Hartley J A; Souhami R L; Grimaldi K A
Strand-specific measurement of cisplatin-induced DNA damage and repair using quantitative PCR.
Nucleic acids research 1996;24(5):987-9.
1995: Wyatt M D; Lee M; Garbiras B J; Souhami R L; Hartley J A
Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: evidence for increased cytotoxicity with enhanced sequence specificity.
Biochemistry 1995;34(40):13034-41.
1995: Hartley J A; Webber J; Wyatt M D; Bordenick N; Lee M
Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: conjugates of pyrene and netropsin analogues.
Bioorganic & medicinal chemistry 1995;3(6):623-9.
1995: Forrow S M; Lee M; Souhami R L; Hartley J A
The effect of AT and GC sequence specific minor groove-binding agents on restriction endonuclease activity.
Chemico-biological interactions 1995;96(2):125-42.
1995: Hartley J A; Preti C S; Wyatt M D; Lee M
Design, synthesis and biological evaluation of benzoic acid mustard derivatives of imidazole-containing and C-terminal carboxamide analogues of distamycin.
Drug design and discovery 1995;12(4):323-35.
1995: Clark A S; Deans B; Stevens M F; Tisdale M J; Wheelhouse R T; Denny B J; Hartley J A
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
Journal of medicinal chemistry 1995;38(9):1493-504.
1995: Rudd G N; Hartley J A; Souhami R L
Persistence of cisplatin-induced DNA interstrand crosslinking in peripheral blood mononuclear cells from elderly and young individuals.
Cancer chemotherapy and pharmacology 1995;35(4):323-6.
1994: Wyatt M D; Garbiras B J; Haskell M K; Lee M; Souhami R L; Hartley J A
Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.
Anti-cancer drug design 1994;9(6):511-25.
1994: Lee M; Preti C S; Vinson E; Wyatt M D; Hartley J A
GC sequence specific recognition by an N-formamido, C-terminus-modified and imidazole-containing analogue of netropsin.
Journal of medicinal chemistry 1994;37(24):4073-5.
1994: Grimaldi K A; Bingham J P; Souhami R L; Hartley J A
DNA damage by anticancer agents and its repair: mapping in cells at the subgene level with quantitative polymerase chain reaction.
Analytical biochemistry 1994;222(1):236-42.
1994: Grimaldi K A; McAdam S R; Souhami R L; Hartley J A
DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells.
Nucleic acids research 1994;22(12):2311-7.
1994: Hartley J A; McAdam S R; Das S; Roldan M C; Haskell M K; Lee M
Molecular and cellular pharmacology of novel photoactive psoralen and coumarin conjugates of pyrrole- and imidazole-containing analogues of netropsin.
Anti-cancer drug design 1994;9(3):181-97.
1994: Lee M; Roldan M C; Haskell M K; McAdam S R; Hartley J A
In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.
Journal of medicinal chemistry 1994;37(8):1208-13.
1993: Puvvada M S; Hartley J A; Jenkins T C; Thurston D E
A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI.
Nucleic acids research 1993;21(16):3671-5.
1993: Hartley J A; Souhami R L; Berardini M D
Electrophoretic and chromatographic separation methods used to reveal interstrand crosslinking of nucleic acids.
Journal of chromatography 1993;618(1-2):277-88.
1993: Lee M; Rhodes A L; Wyatt M D; Forrow S; Hartley J A
Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents.
Anti-cancer drug design 1993;8(3):173-92.
1993: Lee M; Rhodes A L; Wyatt M D; Forrow S; Hartley J A
GC base sequence recognition by oligo(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies.
Biochemistry 1993;32(16):4237-45.
1993: Lee M; Rhodes A L; Wyatt M D; D'Incalci M; Forrow S; Hartley J A
In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin.
Journal of medicinal chemistry 1993;36(7):863-70.
1993: Berardini M D; Souhami R L; Lee C S; Gibson N W; Butler J; Hartley J A
Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase.
Biochemistry 1993;32(13):3306-12.
1992: Meyer D J; Gilmore K S; Harris J M; Hartley J A; Ketterer B
Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases.
British journal of cancer 1992;66(3):433-8.
1992: Gibson N W; Hartley J A; Butler J; Siegel D; Ross D
Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.
Molecular pharmacology 1992;42(3):531-6.
1992: Holley J L; Mather A; Wheelhouse R T; Cullis P M; Hartley J A; Bingham J P; Cohen G M
Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.
Cancer research 1992;52(15):4190-5.
1992: Sunters A; Springer C J; Bagshawe K D; Souhami R L; Hartley J A
The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid.
Biochemical pharmacology 1992;44(1):59-64.
1992: Hartley J A; Bingham J P; Souhami R L
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.
Nucleic acids research 1992;20(12):3175-8.
1992: Lee C S; Hartley J A; Berardini M D; Butler J; Siegel D; Ross D; Gibson N W
Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase.
Biochemistry 1992;31(11):3019-25.
1992: Chresta C M; Hicks R; Hartley J A; Souhami R L
Potentiation of etoposide-induced cytotoxicity and DNA damage in CCRF-CEM cells by pretreatment with non-cytotoxic concentrations of arabinosyl cytosine.
Cancer chemotherapy and pharmacology 1992;31(2):139-45.
1991: Hartley J A; Berardini M; Ponti M; Gibson N W; Thompson A S; Thurston D E; Hoey B M; Butler J
DNA cross-linking and sequence selectivity of aziridinylbenzoquinones: a unique reaction at 5'-GC-3' sequences with 2,5-diaziridinyl-1,4-benzoquinone upon reduction.
Biochemistry 1991;30(50):11719-24.
1991: Fry A M; Chresta C M; Davies S M; Walker M C; Harris A L; Hartley J A; Masters J R; Hickson I D
Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.
Cancer research 1991;51(24):6592-5.
1991: Ponti M; Forrow S M; Souhami R L; D'Incalci M; Hartley J A
Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase.
Nucleic acids research 1991;19(11):2929-33.
1991: Ponti M; Souhami R L; Fox B W; Hartley J A
DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates.
British journal of cancer 1991;63(5):743-7.
1991: Hartley J A; Berardini M D; Souhami R L
An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and "second-arm" crosslink reactions.
Analytical biochemistry 1991;193(1):131-4.
1990: Hartley J A; Forrow S M; Souhami R L
Effect of ionic strength and cationic DNA affinity binders on the DNA sequence selective alkylation of guanine N7-positions by nitrogen mustards.
Biochemistry 1990;29(12):2985-91.
1990: Hartley J A; Forrow S M; Souhami R L; Reszka K; Lown J W
Photosensitization of human leukemic cells by anthracenedione antitumor agents.
Cancer research 1990;50(6):1936-40.
1990: Broggini M; Hartley J A; Mattes W B; Ponti M; Kohn K W; D'Incalci M
DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)
British journal of cancer 1990;61(2):285-9.

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