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Roland Hartmann

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Living Beings

Physiology

Post-Transcriptional RNA Processing

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Co-Publications
Name
30
Erdmann, Volker
15
Willkomm, Dagmar
10
Pfeiffer, Thomas
9
Ulbrich, Norbert
6
Feltens, Ralph
5
Grünweller, Arnold
4
Cuzic, Simona
4
Warnecke, JM
3
Wegscheid, Barbara
3
Limmer, S
3
Müller, PK
3
Busch, S
3
Gruegelsiepe, Heike
3
Heide, Carsten
3
Kruse, Charli

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Publications

TOP 3
Grünweller Arnold; Hartmann Roland K
Expanding RNA silencing approaches by U1 adaptors.
Li Dan; Willkomm Dagmar K; Hartmann Roland K
Minor changes largely restore catalytic activity of archaeal RNase P RNA from Methanothermobacter thermoautotrophicus.
Hartmann Roland K; Gössringer Markus; Späth Bettina; Fischer Susan; Marchfelder Anita
The making of tRNAs and more - RNase P and tRNase Z.

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All Publications

2009: Grünweller Arnold; Hartmann Roland K
Expanding RNA silencing approaches by U1 adaptors.
Chembiochem : a European journal of chemical biology 2009;10(10):1599-601.
2009: Li Dan; Willkomm Dagmar K; Hartmann Roland K
Minor changes largely restore catalytic activity of archaeal RNase P RNA from Methanothermobacter thermoautotrophicus.
Nucleic acids research 2009;37(1):231-42.
2009: Hartmann Roland K; Gössringer Markus; Späth Bettina; Fischer Susan; Marchfelder Anita
The making of tRNAs and more - RNase P and tRNase Z.
Progress in molecular biology and translational science 2009;85():319-68.
2008: Cuzic Simona; Heidemann Karin Abarca; Wöhnert Jens; Hartmann Roland K
Escherichia coli RNase P RNA: substrate ribose modifications at G+1, but not nucleotide -1/+73 base pairing, affect the transition state for cleavage chemistry.
Journal of molecular biology 2008;379(1):1-8.
2008: Marszalkowski Michal; Willkomm Dagmar K; Hartmann Roland K
5'-end maturation of tRNA in aquifex aeolicus.
Biological chemistry 2008;389(4):395-403.
2008: Marszalkowski Michal; Willkomm Dagmar K; Hartmann Roland K
Structural basis of a ribozyme's thermostability: P1-L9 interdomain interaction in RNase P RNA.
RNA (New York, N.Y.) 2008;14(1):127-33.
2007: Li Dan; Willkomm Dagmar K; Schön Astrid; Hartmann Roland K
RNase P of the Cyanophora paradoxa cyanelle: a plastid ribozyme.
Biochimie 2007;89(12):1528-38.
2007: Gösringer Markus; Hartmann Roland K
Function of heterologous and truncated RNase P proteins in Bacillus subtilis.
Molecular microbiology 2007;66(3):801-13.
2007: Cuzic Simona; Hartmann Roland K
A 2'-methyl or 2'-methylene group at G+1 in precursor tRNA interferes with Mg2+ binding at the enzyme-substrate interface in E-S complexes of E. coli RNase P.
Biological chemistry 2007;388(7):717-26.
2007: Willkomm Dagmar K; Hartmann Roland K
An important piece of the RNase P jigsaw solved.
Trends in biochemical sciences 2007;32(6):247-50.
2007: Grünweller Arnold; Hartmann Roland K
Locked nucleic acid oligonucleotides: the next generation of antisense agents?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2007;21(4):235-43.
2007: Wegscheid Barbara; Hartmann Roland K
In vivo and in vitro investigation of bacterial type B RNase P interaction with tRNA 3'-CCA.
Nucleic acids research 2007;35(6):2060-73.
2006: Wegscheid Barbara; Hartmann Roland K
The precursor tRNA 3'-CCA interaction with Escherichia coli RNase P RNA is essential for catalysis by RNase P in vivo.
RNA (New York, N.Y.) 2006;12(12):2135-48.
2006: Marszalkowski Michal; Teune Jan-Hendrik; Steger Gerhard; Hartmann Roland K; Willkomm Dagmar K
Thermostable RNase P RNAs lacking P18 identified in the Aquificales.
RNA (New York, N.Y.) 2006;12(11):1915-21.
2006: Willkomm Dagmar K; Hartmann Roland K
Intricacies and surprises of nuclear-mitochondrial co-evolution.
The Biochemical journal 2006;399(2):e7-9.
2006: Gössringer Markus; Kretschmer-Kazemi Far Rosel; Hartmann Roland K
Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression.
Journal of bacteriology 2006;188(19):6816-23.
2006: Gruegelsiepe Heike; Brandt Ole; Hartmann Roland K
Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria.
The Journal of biological chemistry 2006;281(41):30613-20.
2006: Wegscheid Barbara; Condon Ciarán; Hartmann Roland K
Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences.
EMBO reports 2006;7(4):411-7.
2005: Willkomm Dagmar K; Hartmann Roland K
6S RNA - an ancient regulator of bacterial RNA polymerase rediscovered.
Biological chemistry 2005;386(12):1273-7.
2005: Grünweller A; Hartmann R K
RNA interference as a gene-specific approach for molecular medicine.
Current medicinal chemistry 2005;12(26):3143-61.
2005: Cuzic Simona; Hartmann Roland K
Studies on Escherichia coli RNase P RNA with Zn2+ as the catalytic cofactor.
Nucleic acids research 2005;33(8):2464-74.
2005: Willkomm Dagmar K; Minnerup Jens; Hüttenhofer Alexander; Hartmann Roland K
Experimental RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog.
Nucleic acids research 2005;33(6):1949-60.
2004: Hartmann Roland K; Mörl Mario; Sprinzl Mathias
The tRNA world.
RNA (New York, N.Y.) 2004;10(3):344-9.
2003: Hartmann Enno; Hartmann Roland K
The enigma of ribonuclease P evolution.
Trends in genetics : TIG 2003;19(10):561-9.
2003: Gruegelsiepe Heike; Willkomm Dagmar K; Goudinakis Olga; Hartmann Roland K
Antisense inhibition of Escherichia coli RNase P RNA: mechanistic aspects.
Chembiochem : a European journal of chemical biology 2003;4(10):1049-56.
2003: Willkomm Dagmar K; Gruegelsiepe Heike; Goudinakis Olga; Kretschmer-Kazemi Far Rosel; Bald Rolf; Erdmann Volker A; Hartmann Roland K
Evaluation of bacterial RNase P RNA as a drug target.
Chembiochem : a European journal of chemical biology 2003;4(10):1041-8.
2003: Persson Tina; Cuzic Simona; Hartmann Roland K
Catalysis by RNase P RNA: unique features and unprecedented active site plasticity.
The Journal of biological chemistry 2003;278(44):43394-401.
2003: Feltens Ralph; Gossringer Markus; Willkomm Dagmar K; Urlaub Henning; Hartmann Roland K
An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5724-9.
2002: Persson Tina; Hartmann Roland K; Eckstein Fritz
Selection of hammerhead ribozyme variants with low Mg2+ requirement: importance of stem-loop II.
Chembiochem : a European journal of chemical biology 2002;3(11):1066-71.
2002: Willkomm Dagmar K; Feltens Ralph; Hartmann Roland K
tRNA maturation in Aquifex aeolicus.
Biochimie 2002;84(8):713-22.
2002: Rox Christoph; Feltens Ralph; Pfeiffer Thomas; Hartmann Roland K
Potential contact sites between the protein and RNA subunit in the Bacillus subtilis RNase P holoenzyme.
Journal of molecular biology 2002;315(4):551-60.
2001: Hansen A; Pfeiffer T; Zuleeg T; Limmer S; Ciesiolka J; Feltens R; Hartmann R K
Exploring the minimal substrate requirements for trans-cleavage by RNase P holoenzymes from Escherichia coli and Bacillus subtilis.
Molecular microbiology 2001;41(1):131-43.
2001: Heide C; Feltens R; Hartmann R K
Purine N7 groups that are crucial to the interaction of Escherichia coli rnase P RNA with tRNA.
RNA (New York, N.Y.) 2001;7(7):958-68.
2001: Heide C; Busch S; Feltens R; Hartmann R K
Distinct modes of mature and precursor tRNA binding to Escherichia coli RNase P RNA revealed by NAIM analyses.
RNA (New York, N.Y.) 2001;7(4):553-64.
2001: Zuleeg T; Hansen A; Pfeiffer T; Schübel H; Kreutzer R; Hartmann R K; Limmer S
Correlation between processing efficiency for ribonuclease P minimal substrates and conformation of the nucleotide -1 at the cleavage position.
Biochemistry 2001;40(11):3363-9.
2001: Persson T; Kutzke U; Busch S; Held R; Hartmann R K
Chemical synthesis and biological investigation of a 77-mer oligoribonucleotide with a sequence corresponding to E. coli tRNA(Asp).
Bioorganic & medicinal chemistry 2001;9(1):51-6.
2001: Zuleeg T; Hartmann R K; Kreutzer R; Limmer S
NMR spectroscopic evidence for Mn(2+)(Mg(2+)) binding to a precursor-tRNA microhelix near the potential RNase P cleavage site.
Journal of molecular biology 2001;305(2):181-9.
2001: Kruse C; Hartmann R K; Müller P K
Nuclear-cytoplasmic translocation of tRNA.
Experimental cell research 2001;262(1):3-7.
2000: Busch S; Kirsebom L A; Notbohm H; Hartmann R K
Differential role of the intermolecular base-pairs G292-C(75) and G293-C(74) in the reaction catalyzed by Escherichia coli RNase P RNA.
Journal of molecular biology 2000;299(4):941-51.
2000: Warnecke J M; Nitschke M; Moolenaar C E; Rietschel E T; Hartmann R K; Mamat U
The 5'-proximal hairpin loop of lbi RNA is a key structural element in repression of D-galactan II biosynthesis in Klebsiella pneumoniae serotype O1.
Molecular microbiology 2000;36(3):697-709.
2000: Pfeiffer T; Tekos A; Warnecke J M; Drainas D; Engelke D R; Séraphin B; Hartmann R K
Effects of phosphorothioate modifications on precursor tRNA processing by eukaryotic RNase P enzymes.
Journal of molecular biology 2000;298(4):559-65.
2000: Kruse C; Willkomm D K; Grünweller A; Vollbrandt T; Sommer S; Busch S; Pfeiffer T; Brinkmann J; Hartmann R K; Müller P K
Export and transport of tRNA are coupled to a multi-protein complex.
The Biochemical journal 2000;346 Pt 1():107-15.
2000: Warnecke J M; Sontheimer E J; Piccirilli J A; Hartmann R K
Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Nucleic acids research 2000;28(3):720-7.
1999: Warnecke J M; Held R; Busch S; Hartmann R K
Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis.
Journal of molecular biology 1999;290(2):433-45.
1999: Heide C; Pfeiffer T; Nolan J M; Hartmann R K
Guanosine 2-NH2 groups of Escherichia coli RNase P RNA involved in intramolecular tertiary contacts and direct interactions with tRNA.
RNA (New York, N.Y.) 1999;5(1):102-16.
1998: Kruse C; Grünweller A; Willkomm D K; Pfeiffer T; Hartmann R K; Müller P K
tRNA is entrapped in similar, but distinct, nuclear and cytoplasmic ribonucleoprotein complexes, both of which contain vigilin and elongation factor 1 alpha.
The Biochemical journal 1998;329 ( Pt 3)():615-21.
1997: Pfeiffer T; Hartmann R K
Role of the spacer boxA of Escherichia coli ribosomal RNA operons in efficient 23 S rRNA synthesis in vivo.
Journal of molecular biology 1997;265(4):385-93.
1996: Hardt W D; Erdmann V A; Hartmann R K
Rp-deoxy-phosphorothioate modification interference experiments identify 2'-OH groups in RNase P RNA that are crucial to tRNA binding.
RNA (New York, N.Y.) 1996;2(12):1189-98.
1996: Warnecke J M; Fürste J P; Hardt W D; Erdmann V A; Hartmann R K
Ribonuclease P (RNase P) RNA is converted to a Cd(2+)-ribozyme by a single Rp-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8924-8.
1996: Hardt W D; Hartmann R K
Mutational analysis of the joining regions flanking helix P18 in E. coli RNase P RNA.
Journal of molecular biology 1996;259(3):422-33.
1995: Pfeiffer T; Jorcke D; Feltens R; Hartmann R K
Direct linkage of str-, S10- and spc-related gene clusters in Thermus thermophilus HB8, and sequences of ribosomal proteins L4 and S10.
Gene 1995;167(1-2):141-5.
1995: Heinrich T; Condon C; Pfeiffer T; Hartmann R K
Point mutations in the leader boxA of a plasmid-encoded Escherichia coli rrnB operon cause defective antitermination in vivo.
Journal of bacteriology 1995;177(13):3793-800.
1995: Hartmann R K; Heinrich J; Schlegl J; Schuster H
Precursor of C4 antisense RNA of bacteriophages P1 and P7 is a substrate for RNase P of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5822-6.
1995: Hardt W D; Warnecke J M; Erdmann V A; Hartmann R K
Rp-phosphorothioate modifications in RNase P RNA that interfere with tRNA binding.
The EMBO journal 1995;14(12):2935-44.
1995: Hardt W D; Schlegl J; Erdmann V A; Hartmann R K
Kinetics and thermodynamics of the RNase P RNA cleavage reaction: analysis of tRNA 3'-end variants.
Journal of molecular biology 1995;247(2):161-72.
1995: Hartmann R K; Krupp G; Hardt W D
Towards a new concept of gene inactivation: specific RNA cleavage by endogenous ribonuclease P.
Biotechnology annual review 1995;1():215-65.
1995: Hardt W D; Warnecke J M; Hartmann R K
Recent approaches to probe functional groups in ribonuclease P RNA by modification interference.
Molecular biology reports 1995;22(2-3):161-9.
1994: Schlegl J; Hardt W D; Erdmann V A; Hartmann R K
Contribution of structural elements to Thermus thermophilus ribonuclease P RNA function.
The EMBO journal 1994;13(20):4863-9.
1994: Ciesiolka J; Hardt W D; Schlegl J; Erdmann V A; Hartmann R K
Lead-ion-induced cleavage of RNase P RNA.
European journal of biochemistry / FEBS 1994;219(1-2):49-56.
1993: Heinrich T; Erdmann V A; Hartmann R K
Sequence of the gene encoding ribosomal protein L11 from Thermus thermophilus HB8.
Gene 1993;136(1-2):373-4.
1993: Hardt W D; Schlegl J; Erdmann V A; Hartmann R K
Role of the D arm and the anticodon arm in tRNA recognition by eubacterial and eukaryotic RNase P enzymes.
Biochemistry 1993;32(48):13046-53.
1993: Hardt W D; Schlegl J; Erdmann V A; Hartmann R K
Gel retardation analysis of E. coli M1 RNA-tRNA complexes.
Nucleic acids research 1993;21(15):3521-7.
1992: Heinrich T; Schröder W; Erdmann V A; Hartmann R K
Identification of the gene encoding transcription factor NusG of Thermus thermophilus.
Journal of bacteriology 1992;174(23):7859-63.
1992: Schlegl J; Fürste J P; Bald R; Erdmann V A; Hartmann R K
Cleavage efficiencies of model substrates for ribonuclease P from Escherichia coli and Thermus thermophilus.
Nucleic acids research 1992;20(22):5963-70.
1992: Voss R H; Hartmann R K; Lippmann C; Alexander C; Jahn O; Erdmann V A
Sequence of the tufA gene encoding elongation factor EF-Tu from Thermus aquaticus and overproduction of the protein in Escherichia coli.
European journal of biochemistry / FEBS 1992;207(3):839-46.
1991: Hartmann R K; Erdmann V A
Analysis of the gene encoding the RNA subunit of ribonuclease P from T. thermophilus HB8.
Nucleic acids research 1991;19(21):5957-64.
1991: Jahn O; Hartmann R K; Boeckh T; Erdmann V A
Comparative analysis of ribosomal protein L5 sequences from bacteria of the genus Thermus.
Biochimie 1991;73(6):669-78.
1991: Jahn O; Hartmann R K; Erdmann V A
Analysis of the spc ribosomal protein operon of Thermus aquaticus.
European journal of biochemistry / FEBS 1991;197(3):733-40.
1991: Hartmann R K; Toschka H Y; Erdmann V A
Processing and termination of 23S rRNA-5S rRNA-tRNA(Gly) primary transcripts in Thermus thermophilus HB8.
Journal of bacteriology 1991;173(8):2681-90.
1990: Wnendt S; Hartmann R K; Ulbrich N; Erdmann V A
Isolation and physical properties of the DNA-directed RNA polymerase from Thermus thermophilus HB8.
European journal of biochemistry / FEBS 1990;191(2):467-72.
1989: Lorenz S; Hartmann R K; Schultze S; Ulbrich N; Erdmann V A
Structural analysis of prokaryotic and eukaryotic 5S rRNAs by RNase H.
Biochimie 1989;71(11-12):1185-91.
1989: Hartmann R K; Erdmann V A
Thermus thermophilus 16S rRNA is transcribed from an isolated transcription unit.
Journal of bacteriology 1989;171(6):2933-41.
1989: Struck J C; Hartmann R K; Toschka H Y; Erdmann V A
Transcription and processing of Bacillus subtilis small cytoplasmic RNA.
Molecular & general genetics : MGG 1989;215(3):478-82.
1988: Hartmann R K; Vogel D W; Walker R T; Erdmann V A
In vitro incorporation of eubacterial, archaebacterial and eukaryotic 5S rRNAs into large ribosomal subunits of Bacillus stearothermophilus.
Nucleic acids research 1988;16(8):3511-24.
1987: Hartmann R K; Ulbrich N; Erdmann V A
Sequences implicated in the processing of Thermus thermophilus HB8 23S rRNA.
Nucleic acids research 1987;15(19):7735-47.
1987: Hartmann R K; Ulbrich N; Erdmann V A
An unusual rRNA operon constellation: in Thermus thermophilus HB8 the 23S/5S rRNA operon is a separate entity from the 16S rRNA operon.
Biochimie 1987;69(10):1097-104.
1987: Vogel D W; Hartmann R K; Struck J C; Ulbrich N; Erdmann V A
The sequence of the 6S RNA gene of Pseudomonas aeruginosa.
Nucleic acids research 1987;15(11):4583-91.
1987: Lorenz S; Hartmann R K; Piel N; Ulbrich N; Erdmann V A
Structural analysis of 5S rRNA, 5S rRNA-protein complexes and ribosomes employing RNase H and d(GTTCGG).
European journal of biochemistry / FEBS 1987;163(2):239-46.
1986: Specht T; Hartmann R K; Ulbrich N; Erdmann V A
Nucleotide sequence of the 5S rRNA from the archaebacterium Halobacterium maris mortui.
Nucleic acids research 1986;14(11):4693.
1986: Hartmann R K; Toschka H Y; Ulbrich N; Erdmann V A
Genomic organization of rDNA in Pseudomonas aeruginosa.
FEBS letters 1986;195(1-2):187-93.
1985: Hartmann R K; Henze P P; Ulbrich N; Erdmann V A
Expression of plasmid encoded Escherichia coli 5S ribosomal ribonucleic acid in Pseudomonas putida.
FEBS letters 1985;188(2):295-301.
1984: Vogel D W; Hartmann R K; Bartsch M; Subramanian A R; Kleinow W; O'Brien T W; Pieler T; Erdmann V A
Reconstitution of 50 S ribosomal subunits from Bacillus stearothermophilus with 5 S RNA from spinach chloroplasts and low-Mr RNA from mitochondria of Locusta migratoria and bovine liver.
FEBS letters 1984;169(1):67-72.

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