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Roland Hartmann

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Markus Gössringer; Roland K Hartmann
3'-UTRs as a source of regulatory RNAs in bacteria.
Liudmila V Pavlova; Walter Rossmanith; Christoph Weber; Aurélie Buzet; Markus Gössringer; Roland K Hartmann
tRNA processing by protein-only versus RNA-based RNase P: kinetic analysis reveals mechanistic differences.
Maren Thomas; Ulrike Weirauch; Roland K Hartmann; Kerstin Lange-Grünweller; Achim Aigner; Udo Bakowsky; Eyas Dayyoub; Arnold Grünweller
PEI-complexed LNA antiseeds as miRNA inhibitors.

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All Publications

2012: Markus Gössringer; Roland K Hartmann
3'-UTRs as a source of regulatory RNAs in bacteria.
The EMBO journal 2012;31(20):3958-60.
2012: Liudmila V Pavlova; Walter Rossmanith; Christoph Weber; Aurélie Buzet; Markus Gössringer; Roland K Hartmann
tRNA processing by protein-only versus RNA-based RNase P: kinetic analysis reveals mechanistic differences.
Chembiochem : a European journal of chemical biology 2012;13(15):2270-6.
2012: Maren Thomas; Ulrike Weirauch; Roland K Hartmann; Kerstin Lange-Grünweller; Achim Aigner; Udo Bakowsky; Eyas Dayyoub; Arnold Grünweller
PEI-complexed LNA antiseeds as miRNA inhibitors.
RNA biology 2012;9(8):1088-98.
2012: Benedikt M Beckmann; Philipp G Hoch; Manja Marz; Margarita Salas; Dagmar K Willkomm; Roland K Hartmann
A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis.
The EMBO journal 2012;31(7):1727-38.
2012: M Thomas; U Weirauch; K Lange-Grünweller; A Aigner; Arnold Grünweller; D Gutsch; Roland K Hartmann
The proto-oncogene Pim-1 is a target of miR-33a.
Oncogene 2012;31(7):918-28.
2012: Markus Gössringer; Dominik Helmecke; Roland K Hartmann
Characterization of RNase P RNA activity.
Methods in molecular biology (Clifton, N.J.) 2012;848():61-72.
2011: Benedikt M Beckmann; Olga Y Burenina; Philipp G Hoch; Elena A Kubareva; Cynthia M Sharma; Roland K Hartmann
In vivo and in vitro analysis of 6S RNA-templated short transcripts in Bacillus subtilis.
RNA biology 2011;8(5):839-49.
2011: Olivia Merkel; Andrea Beyerle; Benedikt M Beckmann; Mengyao Zheng; Roland K Hartmann; Tobias Stöger; Thomas H Kissel
Polymer-related off-target effects in non-viral siRNA delivery.
Biomaterials 2011;32(9):2388-98.
2010: Benedikt M Beckmann; Arnold Grünweller; Michael H W Weber; Roland K Hartmann
Northern blot detection of endogenous small RNAs (approximately14 nt) in bacterial total RNA extracts.
Nucleic acids research 2010;38(14):e147.
2010: Dan Li; Martin H F Meyer; Dagmar K Willkomm; Michael Keusgen; Roland K Hartmann
Analysis of bacterial RNase P RNA and protein interaction by a magnetic biosensor technique.
Biochimie 2010;92(7):772-8.
2009: Simona Cuzic-Feltens; Michael H W Weber; Roland K Hartmann
Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester.
Nucleic acids research 2009;37(22):7638-53.
2009: Arnold Grünweller; Roland K Hartmann
Expanding RNA silencing approaches by U1 adaptors.
Chembiochem : a European journal of chemical biology 2009;10(10):1599-601.
2009: Roland K Hartmann; Markus Gössringer; Bettina Späth; Susan Fischer; Anita Marchfelder
The making of tRNAs and more - RNase P and tRNase Z.
Progress in molecular biology and translational science 2009;85():319-68.
2009: Dan Li; Dagmar K Willkomm; Roland K Hartmann
Minor changes largely restore catalytic activity of archaeal RNase P RNA from Methanothermobacter thermoautotrophicus.
Nucleic acids research 2009;37(1):231-42.
2008: Simona Cuzic; Karin Abarca Heidemann; Jens Wöhnert; Roland K Hartmann
Escherichia coli RNase P RNA: substrate ribose modifications at G+1, but not nucleotide -1/+73 base pairing, affect the transition state for cleavage chemistry.
Journal of molecular biology 2008;379(1):1-8.
2008: Michal Marszalkowski; Dagmar K Willkomm; Roland K Hartmann
5'-end maturation of tRNA in aquifex aeolicus.
Biological chemistry 2008;389(4):395-403.
2008: Michal Marszalkowski; Dagmar K Willkomm; Roland K Hartmann
Structural basis of a ribozyme's thermostability: P1-L9 interdomain interaction in RNase P RNA.
RNA (New York, N.Y.) 2008;14(1):127-33.
2007: Dan Li; Dagmar K Willkomm; Astrid Schön; Roland K Hartmann
RNase P of the Cyanophora paradoxa cyanelle: a plastid ribozyme.
Biochimie 2007;89(12):1528-38.
2007: Markus Gösringer; Roland K Hartmann
Function of heterologous and truncated RNase P proteins in Bacillus subtilis.
Molecular microbiology 2007;66(3):801-13.
2007: Simona Cuzic; Roland K Hartmann
A 2'-methyl or 2'-methylene group at G+1 in precursor tRNA interferes with Mg2+ binding at the enzyme-substrate interface in E-S complexes of E. coli RNase P.
Biological chemistry 2007;388(7):717-26.
2007: Dagmar K Willkomm; Roland K Hartmann
An important piece of the RNase P jigsaw solved.
Trends in biochemical sciences 2007;32(6):247-50.
2007: Arnold Grünweller; Roland K Hartmann
Locked nucleic acid oligonucleotides: the next generation of antisense agents?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2007;21(4):235-43.
2007: Barbara Wegscheid; Roland K Hartmann
In vivo and in vitro investigation of bacterial type B RNase P interaction with tRNA 3'-CCA.
Nucleic acids research 2007;35(6):2060-73.
2006: Barbara Wegscheid; Roland K Hartmann
The precursor tRNA 3'-CCA interaction with Escherichia coli RNase P RNA is essential for catalysis by RNase P in vivo.
RNA (New York, N.Y.) 2006;12(12):2135-48.
2006: Michal Marszalkowski; Jan-Hendrik Teune; Gerhard Steger; Roland K Hartmann; Dagmar K Willkomm
Thermostable RNase P RNAs lacking P18 identified in the Aquificales.
RNA (New York, N.Y.) 2006;12(11):1915-21.
2006: Dagmar K Willkomm; Roland K Hartmann
Intricacies and surprises of nuclear-mitochondrial co-evolution.
The Biochemical journal 2006;399(2):e7-9.
2006: Heike Gruegelsiepe; Ole Brandt; Roland K Hartmann
Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria.
The Journal of biological chemistry 2006;281(41):30613-20.
2006: Markus Gössringer; Rosel Kretschmer-Kazemi Far; Roland K Hartmann
Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression.
Journal of bacteriology 2006;188(19):6816-23.
2006: Barbara Wegscheid; Ciarán Condon; Roland K Hartmann
Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences.
EMBO reports 2006;7(4):411-7.
2005: Dagmar K Willkomm; Roland K Hartmann
6S RNA - an ancient regulator of bacterial RNA polymerase rediscovered.
Biological chemistry 2005;386(12):1273-7.
2005: Arnold Grünweller; Roland K Hartmann
RNA interference as a gene-specific approach for molecular medicine.
Current medicinal chemistry 2005;12(26):3143-61.
2005: Simona Cuzic; Roland K Hartmann
Studies on Escherichia coli RNase P RNA with Zn2+ as the catalytic cofactor.
Nucleic acids research 2005;33(8):2464-74.
2005: Dagmar K Willkomm; Jens Minnerup; Alexander Hüttenhofer; Roland K Hartmann
Experimental RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog.
Nucleic acids research 2005;33(6):1949-60.
2004: Roland K Hartmann; Mario Mörl; Mathias Sprinzl
The tRNA world.
RNA (New York, N.Y.) 2004;10(3):344-9.
2003: Tina Persson; Simona Cuzic; Roland K Hartmann
Catalysis by RNase P RNA: unique features and unprecedented active site plasticity.
The Journal of biological chemistry 2003;278(44):43394-401.
2003: Heike Gruegelsiepe; Dagmar K Willkomm; Olga Goudinakis; Roland K Hartmann
Antisense inhibition of Escherichia coli RNase P RNA: mechanistic aspects.
Chembiochem : a European journal of chemical biology 2003;4(10):1049-56.
2003: Dagmar K Willkomm; Heike Gruegelsiepe; Olga Goudinakis; Rosel Kretschmer-Kazemi Far; Rolf Bald; Volker A Erdmann; Roland K Hartmann
Evaluation of bacterial RNase P RNA as a drug target.
Chembiochem : a European journal of chemical biology 2003;4(10):1041-8.
2003: Enno Hartmann; Roland K Hartmann
The enigma of ribonuclease P evolution.
Trends in genetics : TIG 2003;19(10):561-9.
2003: Ralph Feltens; Markus Gossringer; Dagmar K Willkomm; Henning Urlaub; Roland K Hartmann
An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5724-9.
2002: Tina Persson; Roland K Hartmann; Fritz Eckstein
Selection of hammerhead ribozyme variants with low Mg2+ requirement: importance of stem-loop II.
Chembiochem : a European journal of chemical biology 2002;3(11):1066-71.
2002: Dagmar K Willkomm; Ralph Feltens; Roland K Hartmann
tRNA maturation in Aquifex aeolicus.
Biochimie 2002;84(8):713-22.
2002: Christoph Rox; Ralph Feltens; Thomas Pfeiffer; Roland K Hartmann
Potential contact sites between the protein and RNA subunit in the Bacillus subtilis RNase P holoenzyme.
Journal of molecular biology 2002;315(4):551-60.
2001: A Hansen; Thomas Pfeiffer; T Zuleeg; S Limmer; J Ciesiolka; Ralph Feltens; Roland K Hartmann
Exploring the minimal substrate requirements for trans-cleavage by RNase P holoenzymes from Escherichia coli and Bacillus subtilis.
Molecular microbiology 2001;41(1):131-43.
2001: Carsten Heide; Ralph Feltens; Roland K Hartmann
Purine N7 groups that are crucial to the interaction of Escherichia coli rnase P RNA with tRNA.
RNA (New York, N.Y.) 2001;7(7):958-68.
2001: Carsten Heide; S Busch; Ralph Feltens; Roland K Hartmann
Distinct modes of mature and precursor tRNA binding to Escherichia coli RNase P RNA revealed by NAIM analyses.
RNA (New York, N.Y.) 2001;7(4):553-64.
2001: T Zuleeg; A Hansen; Thomas Pfeiffer; H Schübel; R Kreutzer; Roland K Hartmann; S Limmer
Correlation between processing efficiency for ribonuclease P minimal substrates and conformation of the nucleotide -1 at the cleavage position.
Biochemistry 2001;40(11):3363-9.
2001: T Zuleeg; Roland K Hartmann; R Kreutzer; S Limmer
NMR spectroscopic evidence for Mn(2+)(Mg(2+)) binding to a precursor-tRNA microhelix near the potential RNase P cleavage site.
Journal of molecular biology 2001;305(2):181-9.
2001: T Persson; U Kutzke; S Busch; R Held; Roland K Hartmann
Chemical synthesis and biological investigation of a 77-mer oligoribonucleotide with a sequence corresponding to E. coli tRNA(Asp).
Bioorganic & medicinal chemistry 2001;9(1):51-6.
2001: Charli Kruse; Roland K Hartmann; PK Müller
Nuclear-cytoplasmic translocation of tRNA.
Experimental cell research 2001;262(1):3-7.
2000: S Busch; L A Kirsebom; Holger Notbohm; Roland K Hartmann
Differential role of the intermolecular base-pairs G292-C(75) and G293-C(74) in the reaction catalyzed by Escherichia coli RNase P RNA.
Journal of molecular biology 2000;299(4):941-51.
2000: Thomas Pfeiffer; Apostolos Tekos; JM Warnecke; Denis Drainas; David R Engelke; Bertrand Séraphin; Roland K Hartmann
Effects of phosphorothioate modifications on precursor tRNA processing by eukaryotic RNase P enzymes.
Journal of molecular biology 2000;298(4):559-65.
2000: JM Warnecke; Martin Nitschke; C E Moolenaar; Ernst Th Rietschel; Roland K Hartmann; U Mamat
The 5'-proximal hairpin loop of lbi RNA is a key structural element in repression of D-galactan II biosynthesis in Klebsiella pneumoniae serotype O1.
Molecular microbiology 2000;36(3):697-709.
2000: Charli Kruse; Dagmar K Willkomm; Arnold Grünweller; Tillman Vollbrandt; S Sommer; S Busch; Thomas Pfeiffer; J Brinkmann; Roland K Hartmann; PK Müller
Export and transport of tRNA are coupled to a multi-protein complex.
The Biochemical journal 2000;346 Pt 1():107-15.
2000: JM Warnecke; Erik J Sontheimer; Joseph A Piccirilli; Roland K Hartmann
Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Nucleic acids research 2000;28(3):720-7.
1999: JM Warnecke; R Held; S Busch; Roland K Hartmann
Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis.
Journal of molecular biology 1999;290(2):433-45.
1999: Carsten Heide; Thomas Pfeiffer; James Nolan; Roland K Hartmann
Guanosine 2-NH2 groups of Escherichia coli RNase P RNA involved in intramolecular tertiary contacts and direct interactions with tRNA.
RNA (New York, N.Y.) 1999;5(1):102-16.
1998: Charli Kruse; Arnold Grünweller; Dagmar K Willkomm; Thomas Pfeiffer; Roland K Hartmann; PK Müller
tRNA is entrapped in similar, but distinct, nuclear and cytoplasmic ribonucleoprotein complexes, both of which contain vigilin and elongation factor 1 alpha.
The Biochemical journal 1998;329 ( Pt 3)():615-21.
1997: Thomas Pfeiffer; Roland K Hartmann
Role of the spacer boxA of Escherichia coli ribosomal RNA operons in efficient 23 S rRNA synthesis in vivo.
Journal of molecular biology 1997;265(4):385-93.
1996: W D Hardt; Volker A Erdmann; Roland K Hartmann
Rp-deoxy-phosphorothioate modification interference experiments identify 2'-OH groups in RNase P RNA that are crucial to tRNA binding.
RNA (New York, N.Y.) 1996;2(12):1189-98.
1996: J M Warnecke; Jens P Fürste; W D Hardt; Volker A Erdmann; Roland K Hartmann
Ribonuclease P (RNase P) RNA is converted to a Cd(2+)-ribozyme by a single Rp-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8924-8.
1996: W D Hardt; Roland K Hartmann
Mutational analysis of the joining regions flanking helix P18 in E. coli RNase P RNA.
Journal of molecular biology 1996;259(3):422-33.
1995: Thomas Pfeiffer; D Jorcke; R Feltens; Roland K Hartmann
Direct linkage of str-, S10- and spc-related gene clusters in Thermus thermophilus HB8, and sequences of ribosomal proteins L4 and S10.
Gene 1995;167(1-2):141-5.
1995: T Heinrich; C Condon; Thomas Pfeiffer; Roland K Hartmann
Point mutations in the leader boxA of a plasmid-encoded Escherichia coli rrnB operon cause defective antitermination in vivo.
Journal of bacteriology 1995;177(13):3793-800.
1995: Roland K Hartmann; J Heinrich; J Schlegl; H Schuster
Precursor of C4 antisense RNA of bacteriophages P1 and P7 is a substrate for RNase P of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5822-6.
1995: W D Hardt; J M Warnecke; Volker A Erdmann; Roland K Hartmann
Rp-phosphorothioate modifications in RNase P RNA that interfere with tRNA binding.
The EMBO journal 1995;14(12):2935-44.
1995: W D Hardt; J Schlegl; Volker A Erdmann; Roland K Hartmann
Kinetics and thermodynamics of the RNase P RNA cleavage reaction: analysis of tRNA 3'-end variants.
Journal of molecular biology 1995;247(2):161-72.
1995: Roland K Hartmann; G Krupp; W D Hardt
Towards a new concept of gene inactivation: specific RNA cleavage by endogenous ribonuclease P.
Biotechnology annual review 1995;1():215-65.
1995: W D Hardt; J M Warnecke; Roland K Hartmann
Recent approaches to probe functional groups in ribonuclease P RNA by modification interference.
Molecular biology reports 1995;22(2-3):161-9.
1994: J Schlegl; W D Hardt; Volker A Erdmann; Roland K Hartmann
Contribution of structural elements to Thermus thermophilus ribonuclease P RNA function.
The EMBO journal 1994;13(20):4863-9.
1994: J Ciesiolka; W D Hardt; J Schlegl; Volker A Erdmann; Roland K Hartmann
Lead-ion-induced cleavage of RNase P RNA.
European journal of biochemistry / FEBS 1994;219(1-2):49-56.
1993: T Heinrich; Volker A Erdmann; Roland K Hartmann
Sequence of the gene encoding ribosomal protein L11 from Thermus thermophilus HB8.
Gene 1993;136(1-2):373-4.
1993: W D Hardt; J Schlegl; Volker A Erdmann; Roland K Hartmann
Role of the D arm and the anticodon arm in tRNA recognition by eubacterial and eukaryotic RNase P enzymes.
Biochemistry 1993;32(48):13046-53.
1993: W D Hardt; J Schlegl; Volker A Erdmann; Roland K Hartmann
Gel retardation analysis of E. coli M1 RNA-tRNA complexes.
Nucleic acids research 1993;21(15):3521-7.
1992: T Heinrich; W Schröder; Volker A Erdmann; Roland K Hartmann
Identification of the gene encoding transcription factor NusG of Thermus thermophilus.
Journal of bacteriology 1992;174(23):7859-63.
1992: J Schlegl; Jens P Fürste; Rolf Bald; Volker A Erdmann; Roland K Hartmann
Cleavage efficiencies of model substrates for ribonuclease P from Escherichia coli and Thermus thermophilus.
Nucleic acids research 1992;20(22):5963-70.
1992: R H Voss; Roland K Hartmann; C Lippmann; C Alexander; O Jahn; Volker A Erdmann
Sequence of the tufA gene encoding elongation factor EF-Tu from Thermus aquaticus and overproduction of the protein in Escherichia coli.
European journal of biochemistry / FEBS 1992;207(3):839-46.
1991: Roland K Hartmann; Volker A Erdmann
Analysis of the gene encoding the RNA subunit of ribonuclease P from T. thermophilus HB8.
Nucleic acids research 1991;19(21):5957-64.
1991: O Jahn; Roland K Hartmann; T Boeckh; Volker A Erdmann
Comparative analysis of ribosomal protein L5 sequences from bacteria of the genus Thermus.
Biochimie 1991;73(6):669-78.
1991: O Jahn; Roland K Hartmann; Volker A Erdmann
Analysis of the spc ribosomal protein operon of Thermus aquaticus.
European journal of biochemistry / FEBS 1991;197(3):733-40.
1991: Roland K Hartmann; H Y Toschka; Volker A Erdmann
Processing and termination of 23S rRNA-5S rRNA-tRNA(Gly) primary transcripts in Thermus thermophilus HB8.
Journal of bacteriology 1991;173(8):2681-90.
1990: S Wnendt; Roland K Hartmann; Norbert Ulbrich; Volker A Erdmann
Isolation and physical properties of the DNA-directed RNA polymerase from Thermus thermophilus HB8.
European journal of biochemistry / FEBS 1990;191(2):467-72.
1989: S Lorenz; Roland K Hartmann; S Schultze; Norbert Ulbrich; Volker A Erdmann
Structural analysis of prokaryotic and eukaryotic 5S rRNAs by RNase H.
Biochimie 1989;71(11-12):1185-91.
1989: Roland K Hartmann; Volker A Erdmann
Thermus thermophilus 16S rRNA is transcribed from an isolated transcription unit.
Journal of bacteriology 1989;171(6):2933-41.
1989: Joachim Struck; Roland K Hartmann; H Y Toschka; Volker A Erdmann
Transcription and processing of Bacillus subtilis small cytoplasmic RNA.
Molecular & general genetics : MGG 1989;215(3):478-82.
1988: Roland K Hartmann; D W Vogel; R T Walker; Volker A Erdmann
In vitro incorporation of eubacterial, archaebacterial and eukaryotic 5S rRNAs into large ribosomal subunits of Bacillus stearothermophilus.
Nucleic acids research 1988;16(8):3511-24.
1987: Roland K Hartmann; Norbert Ulbrich; Volker A Erdmann
Sequences implicated in the processing of Thermus thermophilus HB8 23S rRNA.
Nucleic acids research 1987;15(19):7735-47.
1987: Roland K Hartmann; Norbert Ulbrich; Volker A Erdmann
An unusual rRNA operon constellation: in Thermus thermophilus HB8 the 23S/5S rRNA operon is a separate entity from the 16S rRNA operon.
Biochimie 1987;69(10):1097-104.
1987: D W Vogel; Roland K Hartmann; Joachim Struck; Norbert Ulbrich; Volker A Erdmann
The sequence of the 6S RNA gene of Pseudomonas aeruginosa.
Nucleic acids research 1987;15(11):4583-91.
1987: S Lorenz; Roland K Hartmann; N Piel; Norbert Ulbrich; Volker A Erdmann
Structural analysis of 5S rRNA, 5S rRNA-protein complexes and ribosomes employing RNase H and d(GTTCGG).
European journal of biochemistry / FEBS 1987;163(2):239-46.
1986: T Specht; Roland K Hartmann; Norbert Ulbrich; Volker A Erdmann
Nucleotide sequence of the 5S rRNA from the archaebacterium Halobacterium maris mortui.
Nucleic acids research 1986;14(11):4693.
1986: Roland K Hartmann; H Y Toschka; Norbert Ulbrich; Volker A Erdmann
Genomic organization of rDNA in Pseudomonas aeruginosa.
FEBS letters 1986;195(1-2):187-93.
1985: Roland K Hartmann; P P Henze; Norbert Ulbrich; Volker A Erdmann
Expression of plasmid encoded Escherichia coli 5S ribosomal ribonucleic acid in Pseudomonas putida.
FEBS letters 1985;188(2):295-301.
1984: D W Vogel; Roland K Hartmann; M Bartsch; A R Subramanian; W Kleinow; T W O'Brien; T Pieler; Volker A Erdmann
Reconstitution of 50 S ribosomal subunits from Bacillus stearothermophilus with 5 S RNA from spinach chloroplasts and low-Mr RNA from mitochondria of Locusta migratoria and bovine liver.
FEBS letters 1984;169(1):67-72.