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Leland Hartwell

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Leland H Hartwell; David A Mankoff; Amanda Paulovich; Scott Ramsey; Elizabeth M Swisher
Cancer biomarkers: a systems approach.
Ruedi Aebersold; Leigh Anderson; Richard Caprioli; Brian J Druker; Leland H Hartwell; Richard Smith
Perspective: a program to improve protein biomarker discovery for cancer.
Leland H Hartwell
Yeast and cancer.

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All Publications

2006: Leland H Hartwell; David A Mankoff; Amanda Paulovich; Scott Ramsey; Elizabeth M Swisher
Cancer biomarkers: a systems approach.
Nature biotechnology 2006;24(8):905-8.
2005: Ruedi Aebersold; Leigh Anderson; Richard Caprioli; Brian J Druker; Leland H Hartwell; Richard Smith
Perspective: a program to improve protein biomarker discovery for cancer.
Journal of proteome research 2005;4(4):1104-9.
2004: Leland H Hartwell
Yeast and cancer.
Bioscience reports 2004;24(4-5):523-44.
2004: Leland H Hartwell
Genetics. Robust interactions.
Science (New York, N.Y.) 2004;303(5659):774-5.
2003: Ruth Etzioni; Nicole Urban; Scott Ramsey; Martin McIntosh; Stephen Schwartz; Brian Reid; Jerald P Radich; Garnet Anderson; Leland H Hartwell
The case for early detection.
Nature reviews. Cancer 2003;3(4):243-52.
2002: Leland H Hartwell
Nobel Lecture. Yeast and cancer.
Bioscience reports 2002;22(3-4):373-94.
2001: Leland H Hartwell
Interview: Leland Hartwell, PhD, Nobel Prize for Medicine winner.
MedGenMed : Medscape general medicine 2001;3(4):3.
2001: J L Hartman; B Garvik; Leland H Hartwell
Principles for the buffering of genetic variation.
Science (New York, N.Y.) 2001;291(5506):1001-4.
2001: A Emili; D M Schieltz; J R Yates; Leland H Hartwell
Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1.
Molecular cell 2001;7(1):13-20.
2000: Julian A Simon; Philippe Szankasi; D K Nguyen; C Ludlow; H M Dunstan; C J Roberts; E L Jensen; Leland H Hartwell; Stephen H Friend
Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae.
Cancer research 2000;60(2):328-33.
1999: Leland H Hartwell; J J Hopfield; S Leibler; A W Murray
From molecular to modular cell biology.
Nature 1999;402(6761 Suppl):C47-52.
1998: Matthew J Marton; Joe L DeRisi; Holly Bennett; Vishwanath R Iyer; Michael R Meyer; C J Roberts; Roland B Stoughton; Julja Burchard; D Slade; H Dai; D E Bassett; Leland H Hartwell; P O Brown; S H Friend
Drug target validation and identification of secondary drug target effects using DNA microarrays.
Nature medicine 1998;4(11):1293-301.
1998: Paul Nurse; Y Masui; Leland H Hartwell
Understanding the cell cycle.
Nature medicine 1998;4(10):1103-6.
1998: Amanda Paulovich; C D Armour; Leland H Hartwell
The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage.
Genetics 1998;150(1):75-93.
1998: P O Brown; Leland H Hartwell
Genomics and human disease--variations on variation.
Nature genetics 1998;18(2):91-3.
1997: Leland H Hartwell; Philippe Szankasi; Christopher J Roberts; Andrew W Murray; Stephen H Friend
Integrating genetic approaches into the discovery of anticancer drugs.
Science (New York, N.Y.) 1997;278(5340):1064-8.
1997: Enrico Mihich; Leland H Hartwell
Eighth Annual Pezcoller Symposium: genomic instability and immortality in cancer.
Cancer research 1997;57(19):4437-41.
1997: David P Toczyski; David J Galgoczy; Leland H Hartwell
CDC5 and CKII control adaptation to the yeast DNA damage checkpoint.
Cell 1997;90(6):1097-106.
1997: K Schrick; BM Garvik; Leland H Hartwell
Mating in Saccharomyces cerevisiae: the role of the pheromone signal transduction pathway in the chemotropic response to pheromone.
Genetics 1997;147(1):19-32.
1997: R Dorer; C Boone; T Kimbrough; J Kim; Leland H Hartwell
Genetic analysis of default mating behavior in Saccharomyces cerevisiae.
Genetics 1997;146(1):39-55.
1997: Jason M Wooden; Leland H Hartwell; B Vasquez; Carol Hopkins Sibley
Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum.
Molecular and biochemical parasitology 1997;85(1):25-40.
1997: Amanda Paulovich; David P Toczyski; Leland H Hartwell
When checkpoints fail.
Cell 1997;88(3):315-21.
1997: Amanda Paulovich; R U Margulies; BM Garvik; Leland H Hartwell
RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.
Genetics 1997;145(1):45-62.
1996: P M Pryciak; Leland H Hartwell
AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction.
Molecular and cellular biology 1996;16(6):2614-26.
1995: B Garvik; M Carson; Leland H Hartwell
Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint.
Molecular and cellular biology 1995;15(11):6128-38.
1995: R Dorer; P M Pryciak; Leland H Hartwell
Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.
The Journal of cell biology 1995;131(4):845-61.
1995: Amanda Paulovich; Leland H Hartwell
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage.
Cell 1995;82(5):841-7.
1995: Leland H Hartwell
1994 forbeck cancer forum on cell cycle checkpoints.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(9):1067.
1994: Leland H Hartwell; M B Kastan
Cell cycle control and cancer.
Science (New York, N.Y.) 1994;266(5192):1821-8.
1994: Leland H Hartwell
Cell cycle. cAMPing out.
Nature 1994;371(6495):286.
1994: Ted Weinert; Gretchen Kiser; Leland H Hartwell
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
Genes & development 1994;8(6):652-65.
1994: R Dorer; P Pryciak; K Schrick; Leland H Hartwell
The induction of cell polarity by pheromone in Saccharomyces cerevisiae.
Harvey lectures 1994;90():95-104.
1994: Leland H Hartwell; Ted Weinert; L Kadyk; B Garvik
Cell cycle checkpoints, genomic integrity, and cancer.
Cold Spring Harbor symposia on quantitative biology 1994;59():259-63.
1993: M T Brown; L Goetsch; Leland H Hartwell
MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae.
The Journal of cell biology 1993;123(2):387-403.
1993: Ted Weinert; Leland H Hartwell
Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.
Genetics 1993;134(1):63-80.
1993: L C Kadyk; Leland H Hartwell
Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae.
Genetics 1993;133(3):469-87.
1992: Leland H Hartwell
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.
Cell 1992;71(4):543-6.
1992: L C Kadyk; Leland H Hartwell
Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.
Genetics 1992;132(2):387-402.
1992: Leland H Hartwell
Bringing the basic scientist into human disease research.
Molecular biology of the cell 1992;3(8):837-8.
1992: Leland H Hartwell
Alfred P. Sloan, Jr. Prize. Role of yeast in cancer research.
Cancer 1992;69(10):2615-21.
1991: Leland H Hartwell
Twenty-five years of cell cycle genetics.
Genetics 1991;129(4):975-80.
1991: C L Jackson; J B Konopka; Leland H Hartwell
S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination.
Cell 1991;67(2):389-402.
1991: Leland H Hartwell
Yeast embryology. Pathways of morphogenesis.
Nature 1991;352(6337):663-4.
1991: P E Neiman; Leland H Hartwell
Malignant instability. Workshop on Genetic Instability and its Role in Carcinogenesis sponsored by the Programs in Molecular Medicine of the Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA, January 11-12, 1991.
The New biologist 1991;3(4):347-51.
1991: M Brown; B Garvik; Leland H Hartwell; L Kadyk; T Seeley; Ted Weinert
Fidelity of mitotic chromosome transmission.
Cold Spring Harbor symposia on quantitative biology 1991;56():359-65.
1990: Ted Weinert; Leland H Hartwell
Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage.
Molecular and cellular biology 1990;10(12):6554-64.
1990: C L Jackson; Leland H Hartwell
Courtship in S. cerevisiae: both cell types choose mating partners by responding to the strongest pheromone signal.
Cell 1990;63(5):1039-51.
1990: C L Jackson; Leland H Hartwell
Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating.
Molecular and cellular biology 1990;10(5):2202-13.
1989: Leland H Hartwell; Ted Weinert
Checkpoints: controls that ensure the order of cell cycle events.
Science (New York, N.Y.) 1989;246(4930):629-34.
1989: D Burke; P Gasdaska; Leland H Hartwell
Dominant effects of tubulin overexpression in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(3):1049-59.
1989: Ted Weinert; Leland H Hartwell
Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae.
Journal of cell science. Supplement 1989;12():145-8.
1988: J B Konopka; D D Jenness; Leland H Hartwell
The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromone.
Cell 1988;54(5):609-20.
1988: Ted Weinert; Leland H Hartwell
The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.
Science (New York, N.Y.) 1988;241(4863):317-22.
1988: F Cross; Leland H Hartwell; C Jackson; J B Konopka
Conjugation in Saccharomyces cerevisiae.
Annual review of cell biology 1988;4():429-57.
1987: Douglas Koshland; Leland H Hartwell
The structure of sister minichromosome DNA before anaphase in Saccharomyces cerevisiae.
Science (New York, N.Y.) 1987;238(4834):1713-6.
1987: D D Jenness; Barry Goldman; Leland H Hartwell
Saccharomyces cerevisiae mutants unresponsive to alpha-factor pheromone: alpha-factor binding and extragenic suppression.
Molecular and cellular biology 1987;7(4):1311-9.
1987: Douglas Koshland; L Rutledge; M Fitzgerald-Hayes; Leland H Hartwell
A genetic analysis of dicentric minichromosomes in Saccharomyces cerevisiae.
Cell 1987;48(5):801-12.
1986: D Meeks-Wagner; J S Wood; B Garvik; Leland H Hartwell
Isolation of two genes that affect mitotic chromosome transmission in S. cerevisiae.
Cell 1986;44(1):53-63.
1986: D Meeks-Wagner; Leland H Hartwell
Normal stoichiometry of histone dimer sets is necessary for high fidelity of mitotic chromosome transmission.
Cell 1986;44(1):43-52.
1986: D D Jenness; A C Burkholder; Leland H Hartwell
Binding of alpha-factor pheromone to Saccharomyces cerevisiae a cells: dissociation constant and number of binding sites.
Molecular and cellular biology 1986;6(1):318-20.
1985: A C Burkholder; Leland H Hartwell
The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene.
Nucleic acids research 1985;13(23):8463-75.
1985: M J Carson; Leland H Hartwell
CDC17: an essential gene that prevents telomere elongation in yeast.
Cell 1985;42(1):249-57.
1985: Leland H Hartwell; D Smith
Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae.
Genetics 1985;110(3):381-95.
1985: Douglas Koshland; J C Kent; Leland H Hartwell
Genetic analysis of the mitotic transmission of minichromosomes.
Cell 1985;40(2):393-403.
1983: D D Jenness; A C Burkholder; Leland H Hartwell
Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor.
Cell 1983;35(2 Pt 1):521-9.
1983: Susan Dutcher; Leland H Hartwell
Test for temporal or spatial restrictions in gene product function during the cell division cycle.
Molecular and cellular biology 1983;3(7):1255-65.
1983: Susan Dutcher; Leland H Hartwell
Genes that act before conjugation to prepare the Saccharomyces cerevisiae nucleus for caryogamy.
Cell 1983;33(1):203-10.
1982: J S Wood; Leland H Hartwell
A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae.
The Journal of cell biology 1982;94(3):718-26.
1982: Susan Dutcher; Leland H Hartwell
The role of S. cerevisiae cell division cycle genes in nuclear fusion.
Genetics 1982;100(2):175-84.
1980: Leland H Hartwell
Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.
The Journal of cell biology 1980;85(3):811-22.
1978: Leland H Hartwell
Cell division from a genetic perspective.
The Journal of cell biology 1978;77(3):627-37.
1977: Leland H Hartwell; M W Unger
Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.
The Journal of cell biology 1977;75(2 Pt 1):422-35.
1977: B J Reid; Leland H Hartwell
Regulation of mating in the cell cycle of Saccharomyces cerevisiae.
The Journal of cell biology 1977;75(2 Pt 1):355-65.
1977: G C Johnston; J R Pringle; Leland H Hartwell
Coordination of growth with cell division in the yeast Saccharomyces cerevisiae.
Experimental cell research 1977;105(1):79-98.
1976: Leland H Hartwell
Sequential function of gene products relative to DNA synthesis in the yeast cell cycle.
Journal of molecular biology 1976;104(4):803-17.
1976: M W Unger; Leland H Hartwell
Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(5):1664-8.
1974: Leland H Hartwell
Saccharomyces cerevisiae cell cycle.
Bacteriological reviews 1974;38(2):164-98.
1974: L M Hereford; Leland H Hartwell
Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis.
Journal of molecular biology 1974;84(3):445-61.
1974: Leland H Hartwell; J Culotti; J R Pringle; B J Reid
Genetic control of the cell division cycle in yeast.
Science (New York, N.Y.) 1974;183(4120):46-51.
1973: Leland H Hartwell
Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae.
Journal of bacteriology 1973;115(3):966-74.
1973: L M Hereford; Leland H Hartwell
Role of protein synthesis in the replication of yeast DNA.
Nature: New biology 1973;244(135):129-31.
1973: Leland H Hartwell; R K Mortimer; J Culotti; M Culotti
Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.
Genetics 1973;74(2):267-86.
1973: R W Shulman; Leland H Hartwell; Jonathan R Warner
Synthesis of ribosomal proteins during the yeast cell cycle.
Journal of molecular biology 1973;73(4):513-25.
1973: E Bücking-Throm; W Duntze; Leland H Hartwell; T R Manney
Reversible arrest of haploid yeast cells in the initiation of DNA synthesis by a diffusible sex factor.
Experimental cell research 1973;76(1):99-110.
1973: Leland H Hartwell
Synchronization of haploid yeast cell cycles, a prelude to conjugation.
Experimental cell research 1973;76(1):111-7.
1971: L M Hereford; Leland H Hartwell
Defective DNA synthesis in permeabilized yeast mutants.
Nature: New biology 1971;234(49):171-2.
1971: Leland H Hartwell
Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis.
Experimental cell research 1971;69(2):265-76.
1971: J Culotti; Leland H Hartwell
Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division.
Experimental cell research 1971;67(2):389-401.
1971: Leland H Hartwell
Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation.
Journal of molecular biology 1971;59(1):183-94.
1970: Leland H Hartwell
Periodic density fluctuation during the yeast cell cycle and the selection of synchronous cultures.
Journal of bacteriology 1970;104(3):1280-5.
1970: Leland H Hartwell; J Culotti; B Reid
Genetic control of the cell-division cycle in yeast. I. Detection of mutants.
Proceedings of the National Academy of Sciences of the United States of America 1970;66(2):352-9.
1970: T E Martin; Leland H Hartwell
Resistance of active yeast ribosomes to dissociation by KCl.
The Journal of biological chemistry 1970;245(6):1504-6.
1970: Leland H Hartwell; C S McLaughlin; Jonathan R Warner
Identification of ten genes that control ribosome formation in yeast.
Molecular & general genetics : MGG 1970;109(1):42-56.
1970: Leland H Hartwell; H T Hutchison; T M Holland; C S McLaughlin
The effect of cycloheximide upon polyribosome stability in two yeast mutants defective respectively in the initiation of polypeptide chains and in messenger RNA synthesis.
Molecular & general genetics : MGG 1970;106(4):347-61.
1970: Leland H Hartwell
Biochemical genetics of yeast.
Annual review of genetics 1970;4():373-96.
1969: C S McLaughlin; P T Magee; Leland H Hartwell
Role of isoleucyl-transfer ribonucleic acid synthetase in ribonucleic acid synthesis and enzyme repression in yeast.
Journal of bacteriology 1969;100(2):579-84.
1969: H T Hutchison; Leland H Hartwell; C S McLaughlin
Temperature-sensitive yeast mutant defective in ribonucleic acid production.
Journal of bacteriology 1969;99(3):807-14.
1969: C S McLaughlin; Leland H Hartwell
A mutant of yeast with a defective methionyl-tRNA synthetase.
Genetics 1969;61(3):557-66.
1969: Leland H Hartwell; C S McLaughlin
A mutant of yeast apparently defective in the initiation of protein synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1969;62(2):468-74.
1969: C S McLaughlin; Leland H Hartwell
Mutants of yeast defective in the initiation of protein biosynthesis.
Cold Spring Harbor symposia on quantitative biology 1969;34():317-9.
1968: Leland H Hartwell; C S McLaughlin
Temperature-sensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis.
Journal of bacteriology 1968;96(5):1664-71.
1968: Leland H Hartwell; C S McLaughlin
Mutants of yeast with temperature-sensitive isoleucyl-tRNA synthetases.
Proceedings of the National Academy of Sciences of the United States of America 1968;59(2):422-8.
1967: H T Hutchison; Leland H Hartwell
Macromolecule synthesis in yeast spheroplasts.
Journal of bacteriology 1967;94(5):1697-705.
1967: Leland H Hartwell
Macromolecule synthesis in temperature-sensitive mutants of yeast.
Journal of bacteriology 1967;93(5):1662-70.
1965: Leland H Hartwell; M Vogt; R Dulbecco
Induction of cellular DNA synthesis by polyoma virus. II. Increase in the rate of enzyme synthesis after infection with polyoma virus in mouse kidney cells.
Virology 1965;27(3):262-72.
1965: R Dulbecco; Leland H Hartwell; M VOGT
INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS.
Proceedings of the National Academy of Sciences of the United States of America 1965;53():403-10.
1964: Leland H Hartwell; B MAGASANIK
THE MECHANISM OF HISTIDASE INDUCTION AND FORMATION IN BACILLUS SUBTILIS.
Journal of molecular biology 1964;10():105-19.
1963: Leland H Hartwell; B MAGASANIK
THE MOLECULAR BASIS OF HISTIDASE INDUCTION IN BACILLUS SUBTILIS.
Journal of molecular biology 1963;7():401-20.
1961: Leland H Hartwell
An upper limit to the map distance separating the two cistrons of the rII region of bacteriophage T4B.
Virology 1961;15():510-1.