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Ronald Harvey

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TOP 3
Daiwang Xu; Trevor M Penning; Ian Blair; Ronald G Harvey
Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.
Daiwang Xu; Yazhen Duan; Ian Blair; Trevor M Penning; Ronald G Harvey
Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues.
Chongzhao Ran; Qing Dai; Qian Ruan; Trevor M Penning; Ian Blair; Ronald G Harvey
Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides.

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All Publications

2009: Daiwang Xu; Trevor M Penning; Ian Blair; Ronald G Harvey
Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.
The Journal of organic chemistry 2009;74(2):597-604.
2008: Daiwang Xu; Yazhen Duan; Ian Blair; Trevor M Penning; Ronald G Harvey
Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues.
Organic letters 2008;10(6):1059-62.
2008: Chongzhao Ran; Qing Dai; Qian Ruan; Trevor M Penning; Ian Blair; Ronald G Harvey
Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides.
The Journal of organic chemistry 2008;73(3):992-1003.
2007: Qing Dai; Daiwang Xu; Keunpoong Lim; Ronald G Harvey
Efficient syntheses of C(8)-aryl adducts of adenine and guanine formed by reaction of radical cation metabolites of carcinogenic polycyclic aromatic hydrocarbons with DNA.
The Journal of organic chemistry 2007;72(13):4856-63.
2005: Chongzhao Ran; Qing Dai; Ronald G Harvey
N6-Arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with aryl halides.
The Journal of organic chemistry 2005;70(9):3724-6.
2005: Qing Dai; Chongzhao Ran; Ronald G Harvey
Synthesis of adducts of o-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides.
Organic letters 2005;7(6):999-1002.
2004: Ronald G Harvey; Qing Dai; Chongzhao Ran; Trevor M Penning
Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis.
The Journal of organic chemistry 2004;69(6):2024-32.
2004: Ronald G Harvey; Keunpoong Lim; Qing Dai
A convenient new synthesis of benzo[a]pyrene.
The Journal of organic chemistry 2004;69(4):1372-3.
2002: Ji-Quan Wang; Eric H Weyand; Ronald G Harvey
Synthesis of suspected carcinogenic metabolites of 7H-benzo[c]fluorene, a coal tar component implicated in causation of lung tumors.
The Journal of organic chemistry 2002;67(17):6216-9.
2000: Moon-shong Tang; Suryanarayana V Vulimiri; Aurora Viaje; J X Chen; D S Bilolikar; R J Morris; Ronald G Harvey; Thomas Slaga; John DiGiovanni
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Cancer research 2000;60(20):5688-95.
2000: A Koganti; R Singh; K Rozett; N Modi; Lawrence S Goldstein; T A Roy; FJ Zhang; Ronald G Harvey; Eric H Weyand
7H-benzo[c]fluorene: a major DNA adduct-forming component of coal tar.
Carcinogenesis 2000;21(8):1601-9.
2000: FJ Zhang; Cecilia N Cortez; Ronald G Harvey
New synthetic approaches to polycyclic aromatic hydrocarbons and their carcinogenic oxidized metabolites: derivatives of benzo[s]picene, benzo[rst]pentaphene, and dibenzo[b,def]chrysene.
The Journal of organic chemistry 2000;65(13):3952-60.
2000: H Khalili; FJ Zhang; Ronald G Harvey; Anthony Dipple
Mutagenicity of benzo[a]pyrene-deoxyadenosine adducts in a sequence context derived from the p53 gene.
Mutation research 2000;465(1-2):39-44.
1999: R Agarwal; Stephanie L Coffing; William M Baird; Ronald G Harvey; Anthony Dipple
Metabolic activation of 4H-cyclopenta[def]chrysene in human mammary carcinoma MCF-7 cell cultures.
Chemical research in toxicology 1999;12(5):437-41.
1999: J Szeliga; S Amin; FJ Zhang; Ronald G Harvey
Reactions of dihydrodiol epoxides of 5-methylchrysene and 5, 6-dimethylchrysene with DNA and deoxyribonucleotides.
Chemical research in toxicology 1999;12(4):347-52.
1999: Suryanarayana V Vulimiri; Wanda Baer-Dubowska; Ronald G Harvey; J T Zhang; John DiGiovanni
Analysis of highly polar DNA adducts formed in SENCAR mouse epidermis following topical application of dibenz[a,j]anthracene.
Chemical research in toxicology 1999;12(1):60-7.
1998: R Jarabak; Ronald G Harvey; J Jarabak
Redox cycling of polycyclic aromatic hydrocarbon o-quinones: metal ion-catalyzed oxidation of catechols bypasses inhibition by superoxide dismutase.
Chemico-biological interactions 1998;115(3):201-13.
1997: Wanda Baer-Dubowska; Suryanarayana V Vulimiri; Ronald G Harvey; Cecilia N Cortez; John DiGiovanni
Analysis of 7-methylbenz[a]anthracene-DNA adducts formed in SENCAR mouse epidermis by 32P-postlabeling.
Carcinogenesis 1997;18(3):523-9.
1997: R Jarabak; Ronald G Harvey; J Jarabak
Redox cycling of polycyclic aromatic hydrocarbon o-quinones: reversal of superoxide dismutase inhibition by ascorbate.
Archives of biochemistry and biophysics 1997;339(1):92-8.
1997: R Agarwal; Stephanie L Coffing; William M Baird; A S Kiselyov; Ronald G Harvey; Anthony Dipple
Metabolic activation of benzo[g]chrysene in the human mammary carcinoma cell line MCF-7.
Cancer research 1997;57(3):415-9.
1996: J X Chen; A S Kisleyou; Ronald G Harvey; Thomas Slaga; R J Morris; M Tang
Using UvrABC nuclease to detect 7,12-dimethylbenz[a]anthracene anti-diol epoxide-DNA binding specificity in the mouse H-ras gene.
Chemical research in toxicology 1996;9(8):1350-4.
1996: J X Chen; A Pao; Y Zheng; X Ye; A S Kisleyou; R Morris; Thomas Slaga; Ronald G Harvey; Moon-shong Tang
Sequence preference of 7,12-dimethylbenz[a]anthracene-syn-diol epoxide-DNA binding in the mouse H-ras gene detected by UvrABC nucleases.
Biochemistry 1996;35(29):9594-602.
1996: Wanda Baer-Dubowska; R V Nair; A Dubowski; Ronald G Harvey; C Cortez; John DiGiovanni
The effect of fluoro substituents on reactivity of 7-methylbenz[a]anthracene diol epoxides.
Chemical research in toxicology 1996;9(4):722-8.
1996: Z Min; R D Gill; C Cortez; Ronald G Harvey; Edward L Loechler; John DiGiovanni
Targeted A --> T and G --> T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz[a,j]anthracene in M13mp7L2.
Biochemistry 1996;35(13):4128-38.
1996: R Jarabak; Ronald G Harvey; J Jarabak
Polycyclic aromatic hydrocarbon quinone-mediated oxidation reduction cycling catalysed by a human placental 17beta-hydroxysteroid dehydrogenase.
Archives of biochemistry and biophysics 1996;327(1):174-80.
1995: H H Lau; Stephanie L Coffing; H Lee; Ronald G Harvey; William M Baird
Stereoselectivity of activation of 7,12-dimethylbenz[a]anthracene- 3,4-dihydrodiol to the anti-diol epoxide metabolite in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay.
Chemical research in toxicology 1995;8(7):970-8.
1995: Wanda Baer-Dubowska; R V Nair; C Cortez; Ronald G Harvey; John DiGiovanni
Covalent DNA adducts formed in mouse epidermis from dibenz[a,j]anthracene: evidence for the formation of polar adducts.
Chemical research in toxicology 1995;8(2):292-301.
1994: Michael C MacLeod; F E Evans; J Lay; P Chiarelli; N E Geacintov; K Leslie Powell; A Daylong; E Luna; Ronald G Harvey
Identification of a novel, N7-deoxyguanosine adduct as the major DNA adduct formed by a non-bay-region diol epoxide of benzo[a]pyrene with low mutagenic potential.
Biochemistry 1994;33(10):2977-87.
1993: R D Gill; Z Min; C Cortez; Ronald G Harvey; Edward L Loechler; John DiGiovanni
Construction of Escherichia coli vectors containing deoxyadenosine and deoxyguanosine adducts from (+)-anti-dibenz[a,j]anthracene diol epoxide at a defined site.
Chemical research in toxicology 1993;6(5):681-9.
1993: J Jarabak; Ronald G Harvey
Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates.
Archives of biochemistry and biophysics 1993;303(2):394-401.
1993: John DiGiovanni; L Beltrán; A Rupp; Ronald G Harvey; R D Gill
Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice.
Molecular carcinogenesis 1993;8(4):272-9.
1993: William M Baird; H H Lau; I Schmerold; Stephanie L Coffing; S L Brozich; H Lee; Ronald G Harvey
Analysis of polycyclic aromatic hydrocarbon-DNA adducts by postlabelling with the weak beta-emitters 35S-phosphorothioate and 33P-phosphate, immobilized boronate chromatography and high-performance liquid chromatography.
IARC scientific publications 1993;(124):217-26.
1993: R D Gill; H Rodriguez; C Cortez; Ronald G Harvey; Edward L Loechler; John DiGiovanni
Mutagenic specificity of the (+)anti-diol epoxide of dibenz[a,j]anthracene in the supF gene of an Escherichia coli plasmid.
Molecular carcinogenesis 1993;8(3):145-54.
1992: R V Nair; A N Nettikumara; C Cortez; Ronald G Harvey; John DiGiovanni
Comparative metabolism of dibenz[a,j]anthracene and 7-methyldibenz[a,j]anthracene in primary cultures of mouse keratinocytes.
Chemical research in toxicology 1992;5(4):532-40.
1992: R D Gill; L Beltrán; A N Nettikumara; Ronald G Harvey; A Kootstra; John DiGiovanni
Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives.
Molecular carcinogenesis 1992;6(1):53-9.
1991: R V Nair; R D Gill; A N Nettikumara; Wanda Baer-Dubowska; C Cortez; Ronald G Harvey; John DiGiovanni
Characterization of covalently modified deoxyribonucleosides formed from dibenz[a,j]anthracene in primary cultures of mouse keratinocytes.
Chemical research in toxicology 1991;4(1):115-22.
1991: R V Nair; E P Fisher; S H Safe; C Cortez; Ronald G Harvey; John DiGiovanni
Novel coumarins as potential anticarcinogenic agents.
Carcinogenesis 1991;12(1):65-9.
1989: R V Nair; R D Gill; C Cortez; Ronald G Harvey; John DiGiovanni
Characterization of DNA adducts derived from (+/- )-trans-3,4-dihydroxy-anti-1,2-epoxy-1,2,3,4- tetrahydrodibenz[a,j]anthracene and (+/- )-7-methyl-trans-3,4-dihydroxy- anti-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,j]anthracene.
Chemical research in toxicology 1989;2(5):341-8.
1988: Ronald G Harvey; C Cortez; T W Sawyer; J DiGiovanni
Synthesis of the tumorigenic 3,4-dihydrodiol metabolites of dibenz[a,j]anthracene and 7,14-dimethyldibenz[a,j]anthracene.
Journal of medicinal chemistry 1988;31(7):1308-12.
1988: Ronald G Harvey; C Cortez; T Sugiyama; Y Ito; T W Sawyer; J DiGiovanni
Biologically active dihydrodiol metabolites of polycyclic aromatic hydrocarbons structurally related to the potent carcinogenic hydrocarbon 7,12-dimethylbenz[a]anthracene.
Journal of medicinal chemistry 1988;31(1):154-9.
1987: T A Smolarek; S L Morgan; C G Moynihan; H Lee; Ronald G Harvey; William M Baird
Metabolism and DNA adduct formation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in fish cell lines in culture.
Carcinogenesis 1987;8(10):1501-9.