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Koji Hasegawa

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Takahiro Horie; Masahito Horiguchi; Takeshi Kimura; Minako Kinoshita; Toru Kita; Noriaki Kume; Yasuhide Kuwabara; Tomoyuki Nakamura; Osamu Baba; Kazuhisa Chonabayashi; Yoshimasa Chujo; Koji Hasegawa; Masakatsu Hishizawa; Shin Watanabe; Masayuki Yokode; Koh Ono
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.
Naoya Sowa; Rieko Takanabe-Mori; Hiromichi Wada; Shin Watanabe; Akira Shimatsu; Osamu Baba; Koji Hasegawa; Takahiro Horie; Takeshi Kimura; Minako Kinoshita; Yasuhide Kuwabara; Hitoo Nishi; Koh Ono
MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene.
Yoichi Sunagawa; Hidetoshi Suzuki; Hiromichi Wada; Hiroki Sasaki; Akira Shimatsu; Masatoshi Fujita; Hiroyuki Fukuda; Koji Hasegawa; Tadashi Hashimoto; Atsushi Imaizumi; Hideaki Kakeya; Yasufumi Katanasaka; Takeshi Kimura; Tatsuya Morimoto
A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.

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2012: Takahiro Horie; Masahito Horiguchi; Takeshi Kimura; Minako Kinoshita; Toru Kita; Noriaki Kume; Yasuhide Kuwabara; Tomoyuki Nakamura; Osamu Baba; Kazuhisa Chonabayashi; Yoshimasa Chujo; Koji Hasegawa; Masakatsu Hishizawa; Shin Watanabe; Masayuki Yokode; Koh Ono
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.
Journal of the American Heart Association 2012;1(6):e003376.
2012: Naoya Sowa; Rieko Takanabe-Mori; Hiromichi Wada; Shin Watanabe; Akira Shimatsu; Osamu Baba; Koji Hasegawa; Takahiro Horie; Takeshi Kimura; Minako Kinoshita; Yasuhide Kuwabara; Hitoo Nishi; Koh Ono
MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene.
Journal of cellular biochemistry 2012;113(11):3455-65.
2012: Yoichi Sunagawa; Hidetoshi Suzuki; Hiromichi Wada; Hiroki Sasaki; Akira Shimatsu; Masatoshi Fujita; Hiroyuki Fukuda; Koji Hasegawa; Tadashi Hashimoto; Atsushi Imaizumi; Hideaki Kakeya; Yasufumi Katanasaka; Takeshi Kimura; Tatsuya Morimoto
A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.
Biological & pharmaceutical bulletin 2012;35(2):139-44.
2011: Hiroshi Ishikita; Koji Hasegawa; Takumi Noguchi
How does the QB site influence propagate to the QA site in photosystem II?
Biochemistry 2011;50(24):5436-42.
2011: Hitoo Nishi; Koh Ono; Takahiro Horie; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Shin Watanabe; Tomohide Takaya; Yodo Tamaki; Rieko Takanabe-Mori; Hiromichi Wada; Koji Hasegawa; Yoshitaka Iwanaga; Teruhisa Kawamura; Toru Kita; Takeshi Kimura
MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes.
Molecular and cellular biology 2011;31(4):744-55.
2011: Yoichi Sunagawa; Tomohide Takaya; Hiromichi Wada; Shigeki Yanagi; Masatoshi Fujita; Hideaki Kakeya; Yasufumi Katanasaka; Teruhisa Kawamura; Takeshi Kimura; Akira Marui; Tatsuya Morimoto; Ryuzo Sakata; Akira Shimatsu; Koji Hasegawa
A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(9):2151-9.
2010: Shinji Kaichi; Koji Hasegawa; Tatsuya Morimoto
Excessive apoptosis as a downstream molecular event during the development of congenital heart diseases.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(11):2297-8.
2010: Shinji Kaichi; Koji Hasegawa; Tomohide Takaya; Noritaka Yokoo; Takahiro Mima; Teruhisa Kawamura; Tatsuya Morimoto; Koh Ono; Shiro Baba; Hiraku Doi; Shinya Yamanaka; Tatsutoshi Nakahata; Toshio Heike
Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
Cardiovascular research 2010;88(2):314-23.
2010: Takahiro Horie; Koh Ono; Masahito Horiguchi; Hitoo Nishi; Tomoyuki Nakamura; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Hiroyuki Marusawa; Yoshitaka Iwanaga; Koji Hasegawa; Masayuki Yokode; Takeshi Kimura; Toru Kita
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17321-6.
2010: Minako Kinoshita; Koh Ono; Takahiro Horie; Kazuya Nagao; Hitoo Nishi; Yasuhide Kuwabara; Rieko Takanabe-Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura
Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5.
Molecular endocrinology (Baltimore, Md.) 2010;24(10):1978-87.
2010: Takahiro Horie; Koh Ono; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Shin Watanabe; Yasuhide Kuwabara; Yasuhiro Nakashima; Rieko Takanabe-Mori; Eiichiro Nishi; Koji Hasegawa; Toru Kita; Takeshi Kimura
Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.
Cardiovascular research 2010;87(4):656-64.
2010: Kazuya Nagao; Koh Ono; Yoshitaka Iwanaga; Yodo Tamaki; Yoji Kojima; Takahiro Horie; Hitoo Nishi; Minako Kinoshita; Yasuhide Kuwabara; Koji Hasegawa; Toru Kita; Takeshi Kimura
Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress.
Journal of molecular and cellular cardiology 2010;48(6):1157-68.
2010: Hitoo Nishi; Koh Ono; Yoshitaka Iwanaga; Takahiro Horie; Kazuya Nagao; Genzou Takemura; Minako Kinoshita; Yasuhide Kuwabara; Rieko Takanabe Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura
MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes.
The Journal of biological chemistry 2010;285(7):4920-30.
2010: Yoshinori Yoshida; Tatsuya Morimoto; Tomohide Takaya; Teruhisa Kawamura; Yoichi Sunagawa; Hiromichi Wada; Masatoshi Fujita; Akira Shimatsu; Toru Kita; Koji Hasegawa
Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(1):156-62.
2009: Takahiro Horie; Koh Ono; Hitoo Nishi; Yoshitaka Iwanaga; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Rieko Takanabe; Koji Hasegawa; Toru Kita; Takeshi Kimura
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes.
Biochemical and biophysical research communications 2009;389(2):315-20.
2008: Tatsuya Tomo; Yuki Kato; Takehiro Suzuki; Seiji Akimoto; Tatsunori Okubo; Takumi Noguchi; Koji Hasegawa; Tohru Tsuchiya; Kazunori Tanaka; Michitaka Fukuya; Naoshi Dohmae; Tadashi Watanabe; Mamoru Mimuro
Characterization of highly purified photosystem I complexes from the chlorophyll d-dominated cyanobacterium Acaryochloris marina MBIC 11017.
The Journal of biological chemistry 2008;283(26):18198-209.
2008: Takahiro Horie; Koh Ono; Minako Kinoshita; Hitoo Nishi; Kazuya Nagao; Teruhisa Kawamura; Yukiko Abe; Hiromichi Wada; Akira Shimatsu; Toru Kita; Koji Hasegawa
TG-interacting factor is required for the differentiation of preadipocytes.
Journal of lipid research 2008;49(6):1224-34.
2008: Takahiro Horie; Koh Ono; Kazuya Nagao; Hitoo Nishi; Minako Kinoshita; Teruhisa Kawamura; Hiromichi Wada; Akira Shimatsu; Toru Kita; Koji Hasegawa
Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes.
Journal of cellular physiology 2008;215(3):733-42.
2007: Mohsen Hosseinkhani; Koji Hasegawa; Koh Ono; Teruhisa Kawamura; Tomohide Takaya; Tatsuya Morimoto; Hiromichi Wada; Akira Shimatsu; Susana Gonzalez Prat; Hirofumi Suemori; Norio Nakatsuji; Toru Kita
Trichostatin A induces myocardial differentiation of monkey ES cells.
Biochemical and biophysical research communications 2007;356(2):386-91.
2007: Yukiko Abe; Koh Ono; Teruhisa Kawamura; Hiromichi Wada; Toru Kita; Akira Shimatsu; Koji Hasegawa
Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2387-96.
2006: Naoki Kanemitsu; Keiichi Tambara; Goditha U Premaratne; Yu Kimura; Shinji Tomita; Teruhisa Kawamura; Koji Hasegawa; Yasuhiko Tabata; Masashi Komeda
Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006;25(10):1253-62.
2006: Shoichi Miyamoto; Teruhisa Kawamura; Tatsuya Morimoto; Koh Ono; Hiromichi Wada; Yosuke Kawase; Akira Matsumori; Ryosuke Nishio; Toru Kita; Koji Hasegawa
Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo.
Circulation 2006;113(5):679-90.
2005: Zuyi Yuan; Masaomi Nimata; Taka-aki Okabe; Keisuke Shioji; Koji Hasegawa; Toru Kita; Chiharu Kishimoto
Olmesartan, a novel AT1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1147-52.
2005: Genichi Sakaguchi; Keiichi Tambara; Yutaka Sakakibara; Makoto Ozeki; Masaya Yamamoto; Goditha U Premaratne; Xue Lin; Koji Hasegawa; Yasuhiko Tabata; Kazunobu Nishimura; Masashi Komeda
Control-released hepatocyte growth factor prevents the progression of heart failure in stroke-prone spontaneously hypertensive rats.
The Annals of thoracic surgery 2005;79(5):1627-34.
2004: Teruhisa Kawamura; Koji Hasegawa; Tatsuya Morimoto; Atsushi Iwakura; Takeshi Nishina; Takuya Nomoto; Masashi Komeda
Down-regulation of endothelin-1 and alteration of apoptosis signaling following left ventricular volume reduction surgery in heart failure of adult rats.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S366-71.
2004: Maretoshi Hirai; Koh Ono; Tatsuya Morimoto; Teruhisa Kawamura; Hiromichi Wada; Toru Kita; Koji Hasegawa
FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes.
The Journal of biological chemistry 2004;279(36):37640-50.
2004: Natsuhiko Ehara; Koji Hasegawa; Koh Ono; Teruhisa Kawamura; Eri Iwai-Kanai; Tatsuya Morimoto; Masaharu Akao; Souichi Adachi; Toru Kita
Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1.
Biochemical and biophysical research communications 2004;321(2):345-9.
2004: Teruhisa Kawamura; Koh Ono; Tatsuya Morimoto; Masaharu Akao; Eri Iwai-Kanai; Hiromichi Wada; Naoya Sowa; Toru Kita; Koji Hasegawa
Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes.
Circulation research 2004;94(11):1492-9.
2004: Kazuhiko Doi; Koji Hasegawa; Masatoshi Fujita; Ario Yamazato; Kazuo Yamanaka; Masaki Watanabe; Keiichi Tambara; Masashi Komeda
Clinical characteristics relevant to myocardial cell apoptosis: analysis of pericardial fluid.
Interactive cardiovascular and thoracic surgery 2004;3(2):359-62.
2004: Eri Iwai-Kanai; Koji Hasegawa
Intracellular signaling pathways for norepinephrine- and endothelin-1-mediated regulation of myocardial cell apoptosis.
Molecular and cellular biochemistry 2004;259(1-2):163-8.
2004: Teruhisa Kawamura; Koji Hasegawa; Tatsuya Morimoto; Eri Iwai-Kanai; Shoichi Miyamoto; Yosuke Kawase; Koh Ono; Hiromichi Wada; Masaharu Akao; Toru Kita
Expression of p300 protects cardiac myocytes from apoptosis in vivo.
Biochemical and biophysical research communications 2004;315(3):733-8.
2004: Shoichi Miyamoto; Masatoshi Fujita; Keiichi Tambara; Hiroyuki Sekiguchi; Shigeru Eiho; Koji Hasegawa; Shun-ichi Tamaki
Circadian variation of cardiac autonomic nervous activity is well preserved in patients with mild to moderate chronic heart failure: effect of patient position.
International journal of cardiology 2004;93(2-3):247-52.
2004: Natsuhiko Ehara; Koh Ono; Tatsuya Morimoto; Teruhisa Kawamura; Mitsuru Abe; Koji Hasegawa
The possible role of peroxisome proliferator-activated receptor gamma in heart failure.
Experimental and clinical cardiology 2004;9(3):169-73.
2003: Eri Iwai-Kanai; Koji Hasegawa; Souichi Adachi; Masatoshi Fujita; Masaharu Akao; Teruhisa Kawamura; Toru Kita
Effects of endothelin-1 on mitochondrial function during the protection against myocardial cell apoptosis.
Biochemical and biophysical research communications 2003;305(4):898-903.
2003: Tetsuhiko Yanazume; Tatsuya Morimoto; Hiromichi Wada; Teruhisa Kawamura; Koji Hasegawa
Biological role of p300 in cardiac myocytes.
Molecular and cellular biochemistry 2003;248(1-2):115-9.
2003: Tetsuhiko Yanazume; Koji Hasegawa; Tatsuya Morimoto; Teruhisa Kawamura; Hiromichi Wada; Akira Matsumori; Yosuke Kawase; Maretoshi Hirai; Toru Kita
Cardiac p300 is involved in myocyte growth with decompensated heart failure.
Molecular and cellular biology 2003;23(10):3593-606.
2003: Mitsuru Abe; Koji Hasegawa; Hiromichi Wada; Tatsuya Morimoto; Tetsuhiko Yanazume; Teruhisa Kawamura; Maretoshi Hirai; Yutaka Furukawa; Toru Kita
GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(3):404-10.
2003: Kazuaki Kataoka; Koji Hasegawa; Tatsuya Sawamura; Masatoshi Fujita; Tetsuhiko Yanazume; Eri Iwai-Kanai; Teruhisa Kawamura; Taku Hirai; Toru Kita; Ryuji Nohara
LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury.
Biochemical and biophysical research communications 2003;300(3):656-60.
2002: Shoichi Miyamoto; Masatoshi Fujita; Kinzo Ueda; Shun-ichi Tamaki; Koji Hasegawa; Noritoshi Nagaya; Shigetake Sasayama
Shunt between the ventricular chamber and coronary arteries preserves left ventricular function in acute myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(7):633-8.
2002: Akira Matsumori; Yutaka Furukawa; Koji Hasegawa; Yukihito Sato; Hideaki Nakagawa; Yuko Morikawa; Katsuyuki Miura; Yoshiyuki Ohno; Akiko Tamakoshi; Yutaka Inaba; Shigetake Sasayama
Epidemiologic and clinical characteristics of cardiomyopathies in Japan: results from nationwide surveys.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(4):323-36.
2002: Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto; Tsuyoshi Kakita; Tetsuhiko Yanazume; Mitsuru Abe; Shigetake Sasayama
Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription.
The Journal of cell biology 2002;156(6):983-91.
2002: Tetsuhiko Yanazume; Koji Hasegawa; Hiromichi Wada; Tatsuya Morimoto; Mitsuru Abe; Teruhisa Kawamura; Shigetake Sasayama
Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.
The Journal of biological chemistry 2002;277(10):8618-25.
2002: Shoichi Miyamoto; Keiichi Tambara; Shun ichi Tamaki; Noritoshi Nagaya; Koji Hasegawa; Ryuji Nohara; Kunihisa Miwa; Masatoshi Fujita
Effects of right lateral decubitus position on plasma norepinephrine and plasma atrial natriuretic peptide levels in patients with chronic congestive heart failure.
The American journal of cardiology 2002;89(2):240-2.
2002: Eri Iwai-Kanai; Koji Hasegawa; Masatoshi Fujita; Makoto Araki; Tetsuhiko Yanazume; Souichi Adachi; Shigetake Sasayama
Basic fibroblast growth factor protects cardiac myocytes from iNOS-mediated apoptosis.
Journal of cellular physiology 2002;190(1):54-62.
2002: Shoichi Miyamoto; Noritoshi Nagaya; Masaki Ikemoto; Keiichi Tambara; Yasuki Kihara; Yoko Onozawa; Koji Hasegawa; Ario Yamazato; Masatoshi Fujita
Elevation of matrix metalloproteinase-2 level in pericardial fluid is closely associated with left ventricular remodeling.
The American journal of cardiology 2002;89(1):102-5.
2001: Eri Iwai-Kanai; Koji Hasegawa; Tatsuya Sawamura; Masatoshi Fujita; Tetsuhiko Yanazume; Shinya Toyokuni; Souichi Adachi; Yasuki Kihara; Shigetake Sasayama
Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes.
Circulation 2001;104(24):2948-54.
2001: Tatsuya Morimoto; Koji Hasegawa; Hiromichi Wada; Tsuyoshi Kakita; S Kaburagi; Tetsuhiko Yanazume; Shigetake Sasayama
Calcineurin-GATA4 pathway is involved in beta-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes.
The Journal of biological chemistry 2001;276(37):34983-9.
2001: Tsuyoshi Kakita; Koji Hasegawa; Eri Iwai-Kanai; Souichi Adachi; Tatsuya Morimoto; Hiromichi Wada; Teruhisa Kawamura; Tetsuhiko Yanazume; Shigetake Sasayama
Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes.
Circulation research 2001;88(12):1239-46.
2001: Atsushi Iwakura; Masatoshi Fujita; Koji Hasegawa; Shinya Toyokuni; Tatsuya Sawamura; Ryuji Nohara; Shigetake Sasayama; Masashi Komeda
Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway.
Journal of molecular and cellular cardiology 2001;33(3):419-30.
2001: Masatoshi Fujita; Masashi Komeda; Koji Hasegawa; Yasuki Kihara; Ryuji Nohara; Shigetake Sasayama
Pericardial fluid as a new material for clinical heart research.
International journal of cardiology 2001;77(2-3):113-8.
2001: Koji Hasegawa; Eri Iwai-Kanai; Shigetake Sasayama
Neurohormonal regulation of myocardial cell apoptosis during the development of heart failure.
Journal of cellular physiology 2001;186(1):11-8.
2000: Makoto Araki; Koji Hasegawa; Eri Iwai-Kanai; Masatoshi Fujita; Tatsuya Sawamura; Tsuyoshi Kakita; Hiromichi Wada; Tatsuya Morimoto; Shigetake Sasayama
Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.
Journal of the American College of Cardiology 2000;36(4):1411-8.
2000: Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto; Tsuyoshi Kakita; Tetsuhiko Yanazume; Shigetake Sasayama
A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene.
The Journal of biological chemistry 2000;275(33):25330-5.
2000: M Kawai; Yasuki Kihara; Koji Hasegawa; Akira Matsumori; Shigetake Sasayama
Dilated phase of hypertrophic cardiomyopathy with mid-ventricular obstruction after 20-year follow-up.
Japanese circulation journal 2000;64(8):623-6.
2000: T Yoneda; Masatoshi Fujita; Yasuki Kihara; Koji Hasegawa; Tatsuya Sawamura; Tomoko Tanaka; M Inanami; Ryuji Nohara; Shigetake Sasayama
Pericardial fluid from patients with ischemic heart disease accelerates the growth of human vascular smooth muscle cells.
Japanese circulation journal 2000;64(7):495-8.
2000: Atsushi Iwakura; Masatoshi Fujita; Koji Hasegawa; Tatsuya Sawamura; Ryuji Nohara; Shigetake Sasayama; Masashi Komeda
Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis.
Journal of the American College of Cardiology 2000;35(7):1785-90.
2000: Tatsuya Morimoto; Koji Hasegawa; S Kaburagi; Tsuyoshi Kakita; Hiromichi Wada; Tetsuhiko Yanazume; Shigetake Sasayama
Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes.
The Journal of biological chemistry 2000;275(18):13721-6.
2000: M Araki; Mari Tanaka; Koji Hasegawa; R Yokota; T Maeda; M Ishikawa; Y Yabuuchi; Shigetake Sasayama
Nitric oxide inhibition improved myocardial metabolism independent of tissue perfusion during ischemia but not during reperfusion.
Journal of molecular and cellular cardiology 2000;32(3):375-84.
2000: Eri Iwai-Kanai; Koji Hasegawa; Shigetake Sasayama
[Treatment of hypertensive patients associated with ischemic heart disease].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 2():309-11.
2000: H Kanda; Ryuji Nohara; Koji Hasegawa; C Kishimoto; Shigetake Sasayama
A nuclear complex containing PPARalpha/RXRalpha is markedly downregulated in the hypertrophied rat left ventricular myocardium with normal systolic function.
Heart and vessels 2000;15(4):191-6.
2000: I Nakae; Masatoshi Fujita; K Miwa; Koji Hasegawa; Yasuki Kihara; Ryuji Nohara; Shoichi Miyamoto; Kinzo Ueda; Shun-ichi Tamaki; Shigetake Sasayama
Age-dependent impairment of coronary collateral development in humans.
Heart and vessels 2000;15(4):176-80.
2000: Atsushi Iwakura; Masatoshi Fujita; Masaki Ikemoto; Koji Hasegawa; Ryuji Nohara; Shigetake Sasayama; Shoichi Miyamoto; Ario Yamazato; Keiichi Tambara; Masashi Komeda
Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid.
Heart and vessels 2000;15(3):112-6.
2000: Eri Iwai-Kanai; Koji Hasegawa; Shigetake Sasayama
[Ischemic heart disease in hypertensive patients].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():759-62.
1999: Tsuyoshi Kakita; Koji Hasegawa; Tatsuya Morimoto; S Kaburagi; Hiromichi Wada; Shigetake Sasayama
p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene.
The Journal of biological chemistry 1999;274(48):34096-102.
1999: Masatoshi Fujita; I Nakae; Yasuki Kihara; Koji Hasegawa; Ryuji Nohara; Kinzo Ueda; Shun-ichi Tamaki; K Otsuka; Shigetake Sasayama
Determinants of collateral development in patients with acute myocardial infarction.
Clinical cardiology 1999;22(9):595-9.
1999: Masatoshi Fujita; Yasuki Kihara; Koji Hasegawa; Ryuji Nohara; Shigetake Sasayama
Heparin potentiates collateral growth but not growth of intramyocardial endarteries in dogs with repeated coronary occlusion.
International journal of cardiology 1999;70(2):165-70.
1999: Eri Iwai-Kanai; Koji Hasegawa; Makoto Araki; Tsuyoshi Kakita; Tatsuya Morimoto; Shigetake Sasayama
alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes.
Circulation 1999;100(3):305-11.
1999: Akira Matsumori; N Ohashi; Ryosuke Nishio; T Kakio; M Hara; Yoshiaki Furukawa; Koh Ono; Tetsuo Shioi; Koji Hasegawa; Shigetake Sasayama
Apical hypertrophic cardiomyopathy and hepatitis C virus infection.
Japanese circulation journal 1999;63(6):433-8.
1999: Masaki Ikemoto; Koji Hasegawa; Yasuki Kihara; Atsushi Iwakura; Masashi Komeda; Ario Yamazato; Masatoshi Fujita
Development of enzyme-linked immunosorbent assay for acidic fibroblast growth factor and its clinical application.
Clinica chimica acta; international journal of clinical chemistry 1999;283(1-2):171-82.
1999: Tatsuya Morimoto; Koji Hasegawa; S Kaburagi; Tsuyoshi Kakita; Hiroshi Masutani; Richard N Kitsis; Akira Matsumori; Shigetake Sasayama
GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the beta-myosin heavy chain gene in cardiac myocytes.
The Journal of biological chemistry 1999;274(18):12811-8.
1999: K Suzuki; Koji Hasegawa; Ryuji Nohara; Akira Matsumori; Shigetake Sasayama
A patient with hypertrophic cardiomyopathy accompanied by right ventricular dilation of unknown cause.
Japanese circulation journal 1999;63(2):137-40.
1999: T Inada; H Fujiwara; Koji Hasegawa; Makoto Araki; Rikako Yamauchi-Kohno; Hideo Yabana; T Fujiwara; Mari Tanaka; Shigetake Sasayama
Upregulated expression of cardiac endothelin-1 participates in myocardial cell growth in Bio14.6 Syrian cardiomyopathic hamsters.
Journal of the American College of Cardiology 1999;33(2):565-71.
1999: S Kaburagi; Koji Hasegawa; Tatsuya Morimoto; Makoto Araki; Tatsuya Sawamura; Tomoh Masaki; Shigetake Sasayama
The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.
Circulation 1999;99(2):292-8.
1998: Tomoko Tanaka; Masatoshi Fujita; I Nakae; Shun-ichi Tamaki; Koji Hasegawa; Yasuki Kihara; Ryuji Nohara; Shigetake Sasayama
Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina.
Journal of the American College of Cardiology 1998;32(7):1982-6.
1998: K Doyama; M Fukumoto; Genzou Takemura; Mari Tanaka; T Oda; Koji Hasegawa; T Inada; S Ohtani; T Fujiwara; H Itoh; K Nakao; Shigetake Sasayama; H Fujiwara
Expression and distribution of brain natriuretic peptide in human right atria.
Journal of the American College of Cardiology 1998;32(7):1832-8.
1998: Yoshitaka Iwanaga; Yasuki Kihara; Koji Hasegawa; Koichi Inagaki; Takeshi Yoneda; S Kaburagi; Makoto Araki; Shigetake Sasayama
Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats.
Circulation 1998;98(19):2065-73.
1998: Akira Matsumori; N Ohashi; Koji Hasegawa; Shigetake Sasayama; T Eto; T Imaizumi; T Izumi; K Kawamura; M Kawana; A Kimura; A Kitabatake; Masunori Matsuzaki; Ryozo Nagai; H Tanaka; M Hiroe; M Hori; H Inoko; Y Seko; M Sekiguchi; K Shimotohno; Y Sugishita; N Takeda; K Takihara; Mari Tanaka; M Yokoyama
Hepatitis C virus infection and heart diseases: a multicenter study in Japan.
Japanese circulation journal 1998;62(5):389-91.
1998: Tomoko Tanaka; Koji Hasegawa; Masatoshi Fujita; Shun-ichi Tamaki; Ario Yamazato; Yasuki Kihara; Ryuji Nohara; Shigetake Sasayama
Marked elevation of brain natriuretic peptide levels in pericardial fluid is closely associated with left ventricular dysfunction.
Journal of the American College of Cardiology 1998;31(2):399-403.
1998: Masatoshi Fujita; Masaki Ikemoto; Tomoko Tanaka; Shun-ichi Tamaki; Ario Yamazato; T Sawamura; Koji Hasegawa; Yasuki Kihara; Ryuji Nohara; Shigetake Sasayama
Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.
Angiogenesis 1998;2(1):105-8.
1997: S Ohtani; H Fujiwara; Koji Hasegawa; K Doyama; T Inada; Mari Tanaka; T Fujiwara; Shigetake Sasayama
Up-regulated expression of angiotensin II type 1 receptor gene in human pathologic hearts.
Journal of cardiac failure 1997;3(4):303-10.
1997: J Ogawa; H Fujiwara; A Kawamura; M Katsuragawa; T Htay; T Fujiwara; Koji Hasegawa; K Yamasaki; Mari Tanaka; Shigetake Sasayama
Acute cellular damage in medial smooth muscle cells following experimental coronary angioplasty in dog. Damage of cytoskeleton and apoptosis.
Heart and vessels 1997;12(4):157-66.
1996: K Doyama; H Fujiwara; M Fukumoto; M Tanaka; Y Fujiwara; T Oda; T Inada; S Ohtani; Koji Hasegawa; T Fujiwara; Shigetake Sasayama
Tumour necrosis factor is expressed in cardiac tissues of patients with heart failure.
International journal of cardiology 1996;54(3):217-25.
1996: Koji Hasegawa; H Fujiwara; M Koshiji; T Inada; S Ohtani; K Doyama; M Tanaka; Akira Matsumori; T Fujiwara; G Shirakami; Kiminori Hosoda; Kazuwa Nakao; Shigetake Sasayama
Endothelin-1 and its receptor in hypertrophic cardiomyopathy.
Hypertension 1996;27(2):259-64.
1994: M Tanaka; H Fujiwara; K Yamasaki; M Miyamae; R Yokota; Koji Hasegawa; T Fujiwara; Shigetake Sasayama
Ischemic preconditioning elevates cardiac stress protein but does not limit infarct size 24 or 48 h later in rabbits.
The American journal of physiology 1994;267(4 Pt 2):H1476-82.
1994: Koji Hasegawa; H Fujiwara; K Doyama; T Inada; S Ohtani; T Fujiwara; Kiminori Hosoda; Kazuwa Nakao; Shigetake Sasayama
Endothelin-1-selective receptor in the arterial intima of patients with hypertension.
Hypertension 1994;23(3):288-93.
1993: Koji Hasegawa; H Fujiwara; K Doyama; M Miyamae; T Fujiwara; Shinichi Suga; Masashi Mukoyama; Kazuwa Nakao; Hiroshi Imura; Shigetake Sasayama
Ventricular expression of brain natriuretic peptide in hypertrophic cardiomyopathy.
Circulation 1993;88(2):372-80.
1993: M Miyamae; H Fujiwara; M Kida; R Yokota; M Tanaka; M Katsuragawa; Koji Hasegawa; M Ohura; K Koga; Y Yabuuchi
Preconditioning improves energy metabolism during reperfusion but does not attenuate myocardial stunning in porcine hearts.
Circulation 1993;88(1):223-34.
1993: Koji Hasegawa; H Fujiwara; K Doyama; Masashi Mukoyama; Kazuwa Nakao; T Fujiwara; Hiroshi Imura; Chuichi Kawai
Ventricular expression of atrial and brain natriuretic peptides in dilated cardiomyopathy. An immunohistocytochemical study of the endomyocardial biopsy specimens using specific monoclonal antibodies.
The American journal of pathology 1993;142(1):107-16.
1991: Koji Hasegawa; H Fujiwara; H Itoh; Kazuwa Nakao; T Fujiwara; Hiroshi Imura; Chuichi Kawai
Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium. Immunohistocytochemical study using specific monoclonal antibodies.
Circulation 1991;84(3):1203-9.