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Takaaki Hasegawa

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Yoshiteru Tanaka; Katsuhiro Onishi; Yukiko Sakakibara; Miho Fujioka; Takaaki Hasegawa; Miki Katoh; Masayuki Nadai
[Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan].
Kotaro Hitoshi; Kazuo Hotta; Miki Katoh; Shunsuke Kurono; Hiroko Saito; Yoshiteru Tanaka; Takaaki Hasegawa; Masayuki Nadai
Mechanism of drug interaction between a Kampo medicine, byakkokaninjinto, and tetracycline in rats.
Naoko Hirosawa; Jun Ueyama; Takaaki Kondo; Michihiro Kamijima; Kenji Takagi; Sanae Fujinaka; Ayaka Hirate; Takaaki Hasegawa; Shinya Wakusawa
Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats.

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2013: Yoshiteru Tanaka; Katsuhiro Onishi; Yukiko Sakakibara; Miho Fujioka; Takaaki Hasegawa; Miki Katoh; Masayuki Nadai
[Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2013;133(4):463-71.
2012: Kotaro Hitoshi; Kazuo Hotta; Miki Katoh; Shunsuke Kurono; Hiroko Saito; Yoshiteru Tanaka; Takaaki Hasegawa; Masayuki Nadai
Mechanism of drug interaction between a Kampo medicine, byakkokaninjinto, and tetracycline in rats.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2012;18(1):75-82.
2011: Naoko Hirosawa; Jun Ueyama; Takaaki Kondo; Michihiro Kamijima; Kenji Takagi; Sanae Fujinaka; Ayaka Hirate; Takaaki Hasegawa; Shinya Wakusawa
Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats.
Toxicology letters 2011;203(1):28-32.
2010: Jun Ueyama; Shinya Wakusawa; Naoko Hirosawa; Michihiro Kamijima; Akiko Kimata; Takaaki Kondo; Aiko Mochizuki; Kenji Takagi; Takaaki Hasegawa
Toxicokinetics of pyrethroid metabolites in male and female rats.
Environmental toxicology and pharmacology 2010;30(1):88-91.
2010: Jun Ueyama; Michihiro Kamijima; Takaaki Kondo; Kenji Takagi; Eiji Shibata; Takaaki Hasegawa; Shinya Wakusawa; Tomoko Taki; Masahiro Gotoh; Isao Saito
Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(17-18):1257-63.
2010: Jun Ueyama; Tetsuo Satoh; Takaaki Kondo; Kenji Takagi; Eiji Shibata; Masahiro Goto; Akiko Kimata; Isao Saito; Takaaki Hasegawa; Shinya Wakusawa; Michihiro Kamijima
Beta-glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure.
Toxicology letters 2010;193(1):115-9.
2009: Miyoko Matsushima; Kenzo Takagi; Miyuki Ogawa; Etsuko Hirose; Yui Ota; Fumie Abe; Kenji Baba; Takaaki Hasegawa; Yoshinori Hasegawa; Tsutomu Kawabe
Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2009;58(10):705-15.
2009: Jun Ueyama; Akiko Kimata; Michihiro Kamijima; Nobuyuki Hamajima; Yoshinori Ito; Koji Suzuki; Takashi Inoue; Kanami Yamamoto; Kenji Takagi; Isao Saito; Ken-ichi Miyamoto; Takaaki Hasegawa; Takaaki Kondo
Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan.
Environmental research 2009;109(2):175-80.
2008: Jun Ueyama; Masayuki Nadai; Ying Lan Zhao; Hiroaki Kanazawa; Kenzo Takagi; Takaaki Kondo; Kenji Takagi; Shinya Wakusawa; Fumie Abe; Hiroko Saito; Ken-Ichi Miyamoto; Takaaki Hasegawa
Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2.
Biological & pharmaceutical bulletin 2008;31(8):1596-600.
2008: Jun Ueyama; Takaaki Kondo; Ryota Imai; Akiko Kimata; Kanami Yamamoto; Koji Suzuki; Takashi Inoue; Yoshinori Ito; Ken-Ichi Miyamoto; Takaaki Hasegawa; Nobuyuki Hamajima
Association of serum NO( x ) level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan.
Environmental health and preventive medicine 2008;13(1):36-42.
2007: Hironao Nakayama; Kiyoyuki Kitaichi; Yukiko Ito; Katsunori Hashimoto; Kenji Takagi; Toyoharu Yokoi; Kenzo Takagi; Norio Ozaki; Tuneyuki Yamamoto; Takaaki Hasegawa
The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats.
Brain research 2007;1184():260-9.
2007: Masayuki Nadai; Miki Kato; Hideo Yoshizumi; Masao Kimura; Shunsuke Kurono; Fumie Abe; Hiroko Saito; Takaaki Hasegawa
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
Life sciences 2007;81(15):1175-82.
2007: Jun Ueyama; Dong Wang; Takaaki Kondo; Isao Saito; Kenji Takagi; Kenzo Takagi; Michihiro Kamijima; Tamie Nakajima; Ken-Ichi Miyamoto; Shinya Wakusawa; Takaaki Hasegawa
Toxicity of diazinon and its metabolites increases in diabetic rats.
Toxicology letters 2007;170(3):229-37.
2007: Yohei Fujimoto; Kiyoyuki Kitaichi; Hironao Nakayama; Yukiko Ito; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
The pharmacokinetic properties of methamphetamine in rats with previous repeated exposure to methamphetamine: the differences between Long-Evans and Wistar rats.
Experimental animals / Japanese Association for Laboratory Animal Science 2007;56(2):119-29.
2007: Masayuki Nadai; Miki Kato; Kazumasa Yasui; Masao Kimura; Ying Lan Zhao; Jun Ueyama; Yoshimi Tsunekawa; Hideo Yoshizumi; Takaaki Hasegawa
Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats.
Biological & pharmaceutical bulletin 2007;30(3):562-8.
2006: Masayuki Nadai; Chiharu Tajiri; Hideo Yoshizumi; Yuji Suzuki; Ying Lan Zhao; Masao Kimura; Yoshimi Tsunekawa; Takaaki Hasegawa
Effect of chitosan on gastrointestinal absorption of water-insoluble drugs following oral administration in rats.
Biological & pharmaceutical bulletin 2006;29(9):1941-6.
2006: Tatsuya Suzuki; Ying Lan Zhao; Masayuki Nadai; Kazumasa Naruhashi; Akemi Shimizu; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats.
Life sciences 2006;79(5):455-61.
2006: Hiroyuki Nosaka; Masayuki Nadai; Miki Kato; Kazumasa Yasui; Hideo Yoshizumi; Mika Miyoshi; Ying Lan Zhao; Kenji Baba; Kenzo Takagi; Takaaki Hasegawa
Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats.
Life sciences 2006;79(1):50-6.
2006: Hironao Nakayama; Kiyoyuki Kitaichi; Hiroaki Kanazawa; Mai Ando; Yohei Fujimoto; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Effect of Shiga-like toxin II from Escherichia coli O157:H7 on intestinal clearance of norfloxacin in rats.
Life sciences 2006;78(17):1967-74.
2006: Jun Ueyama; Isao Saito; Michihiro Kamijima; Tamie Nakajima; Masahiro Gotoh; Takayoshi Suzuki; Eiji Shibata; Takaaki Kondo; Kenji Takagi; Ken-ichi Miyamoto; Junki Takamatsu; Takaaki Hasegawa; Kenzo Takagi
Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;832(1):58-66.
2006: Shoji Yamaguchi; Ying Lan Zhao; Masayuki Nadai; Hideo Yoshizumi; Xiaobo Cen; Shoko Torita; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport.
Antimicrobial agents and chemotherapy 2006;50(1):80-7.
2005: Kiyoyuki Kitaichi; Masaya Fukuda; Hironao Nakayama; Nagisa Aoyama; Yukiko Ito; Yohei Fujimoto; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice.
Neuroscience letters 2005;382(1-2):195-200.
2005: Masaya Fukuda; Kiyoyuki Kitaichi; Fumie Abe; Yohei Fujimoto; Kenji Takagi; Kenzo Takagi; Tsuneo Morishima; Takaaki Hasegawa
Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice.
Journal of pharmacological sciences 2005;97(4):525-32.
2005: Jun Ueyama; Masayuki Nadai; Hiroaki Kanazawa; Mitsunori Iwase; Hironao Nakayama; Katsunori Hashimoto; Toyoharu Yokoi; Kenji Baba; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters.
European journal of pharmacology 2005;510(1-2):127-34.
2005: Mika Miyoshi; Masayuki Nadai; Atsumi Nitta; Jun Ueyama; Akemi Shimizu; Kenji Takagi; Toshitaka Nabeshima; Kenzo Takagi; Kuniaki Saito; Takaaki Hasegawa
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
European journal of pharmacology 2005;507(1-3):229-37.
2004: Akemi Shimizu; Mika Miyoshi; Masami Sugie; Jun Ueyama; Takuji Yamaguchi; Toshinobu Sasaki; Kenzo Takagi; Mingji Jin; Ken-Ichi Miyamoto; Akira Tsuji; Takaaki Hasegawa
Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.
European journal of pharmacology 2004;501(1-3):151-9.
2004: Kiyoyuki Kitaichi; Yukiko Ito; Masaya Fukuda; Nagisa Aoyama; Hironao Nakayama; Kenzo Takagi; Takaaki Hasegawa
The altered disposition of methamphetamine in the model of methamphetamine-induced neurotoxicity.
Annals of the New York Academy of Sciences 2004;1025():248-56.
2004: Jun Ueyama; Kiyoyuki Kitaichi; Masayuki Nadai; Mitsunori Iwase; Nao Tomyo; Hiroaki Kanazawa; Ryujiro Suzuki; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11.
European journal of pharmacology 2004;498(1-3):257-65.
2004: Kiyoyuki Kitaichi; Hironao Nakayama; Jun Ueyama; Masayuki Nadai; Kenji Baba; Kenji Takagi; Kenzo Takagi; Michio Ohta; Takaaki Hasegawa
Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7.
Biochemical pharmacology 2004;67(8):1427-35.
2004: Akira Nakajima; Kiyofumi Yamada; Taku Nagai; Takehisa Uchiyama; Yoshiaki Miyamoto; Takayoshi Mamiya; Jue He; Atsumi Nitta; Makoto Mizuno; Manh Hung Tran; Aika Seto; Masako Yoshimura; Kiyoyuki Kitaichi; Takaaki Hasegawa; Kuniaki Saito; Yasuhiro Yamada; Mitsuru Seishima; Kenji Sekikawa; Hyoung-Chun Kim; Toshitaka Nabeshima
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(9):2212-25.
2004: Masami Sugie; Emiko Asakura; Ying Lan Zhao; Shoko Torita; Masayuki Nadai; Kenji Baba; Kiyoyuki Kitaichi; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin.
Antimicrobial agents and chemotherapy 2004;48(3):809-14.
2004: Kenji Takagi; Yasuaki Tatsumi; Kiyoyuki Kitaichi; Mitsunori Iwase; Eiji Shibata; Makoto Nakao; Takatoshi Matsumoto; Kenzo Takagi; Takaaki Hasegawa
A sensitive colorimetric assay for polyamines in erythrocytes using oat seedling polyamine oxidase.
Clinica chimica acta; international journal of clinical chemistry 2004;340(1-2):219-27.
2004: Emiko Asakura; Hironao Nakayama; Masami Sugie; Ying Lan Zhao; Masayuki Nadai; Kiyoyuki Kitaichi; Akemi Shimizu; Mika Miyoshi; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats.
European journal of pharmacology 2004;484(2-3):333-9.
2003: Jun Ueyama; Kiyoyuki Kitaichi; Mitsunori Iwase; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(1):35-41.
2003: Kazuhiko Hidemura; Ying Lan Zhao; Katsuki Ito; Akimasa Nakao; Yasuaki Tatsumi; Hiroaki Kanazawa; Kenzo Takagi; Michio Ohta; Takaaki Hasegawa
Shiga-like toxin II impairs hepatobiliary transport of doxorubicin in rats by down-regulation of hepatic P glycoprotein and multidrug resistance-associated protein Mrp2.
Antimicrobial agents and chemotherapy 2003;47(5):1636-42.
2003: Miyoko Matsushima; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Takaaki Hasegawa; Kenzo Takagi
The expression of mRNA for calcitonin receptor-like receptor/receptor-activity modifying proteins in rat peritoneal mast cells.
European journal of pharmacology 2003;464(2-3):111-4.
2003: Kiyoyuki Kitaichi; Yuki Morishita; Yuko Doi; Jun Ueyama; Miyoko Matsushima; Ying Lan Zhao; Kenzo Takagi; Takaaki Hasegawa
Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats.
European journal of pharmacology 2003;464(1):39-48.
2002: Ying Lan Zhao; Jun Du; Hiroaki Kanazawa; Xiaobo Cen; Kenzo Takagi; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Kenji Takagi; Michio Ohta; Takaaki Hasegawa
Shiga-like toxin II modifies brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice.
Brain research 2002;956(2):246-53.
2002: Ryujiro Suzuki; Tomoki Kimura; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Miyoko Matsushima; Ying Lan Zhao; Eiji Shibata; Kenji Baba; Takaaki Hasegawa; Kenzo Takagi
Platelet factor 4 fragment induces histamine release from rat peritoneal mast cells.
Peptides 2002;23(10):1713-7.
2002: Ying Lan Zhao; Jun Du; Hiroaki Kanazawa; Ayako Sugawara; Kenji Takagi; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Kenzo Takagi; Takaaki Hasegawa
Effect of endotoxin on doxorubicin transport across blood-brain barrier and P-glycoprotein function in mice.
European journal of pharmacology 2002;445(1-2):115-23.
2002: Ying Lan Zhao; Xiaobo Cen; Masafumi Ito; Keiko Yokoyama; Kenji Takagi; Kiyoyuki Kitaichi; Masayuki Nadai; Michio Ohta; Kenzo Takagi; Takaaki Hasegawa
Shiga-like toxin II derived from Escherichia coli O157:H7 modifies renal handling of levofloxacin in rats.
Antimicrobial agents and chemotherapy 2002;46(5):1522-8.
2002: Ying Lan Zhao; Shao Hui Cai; Li Wang; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Masayuki Nadai; Hideo Yoshizumi; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Possible involvement of P-glycoprotein in the biliary excretion of grepafloxacin.
Clinical and experimental pharmacology & physiology 2002;29(3):167-72.
2002: Masayuki Takeuchi; Yasuaki Tatsumi; Kiyoyuki Kitaichi; Kenji Baba; Ryujiro Suzuki; Eiji Shibata; Kenji Takagi; Ken-ichi Miyamoto; Takaaki Hasegawa; Kenzo Takagi
Selective phosphodiesterase type 4 inhibitors reduce the prolonged survival of eosinophils stimulated by granulocyte-macrophage colony-stimulating factor.
Biological & pharmaceutical bulletin 2002;25(2):184-7.
2001: N Yoshida; Y Shimizu; Kiyoyuki Kitaichi; K Hiramatsu; Masayuki Takeuchi; Yasushi Ito; Hiroaki Kume; Kenichi Yamaki; Ryujiro Suzuki; Eiji Shibata; Takaaki Hasegawa; Kenji Takagi
Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells.
Clinical and experimental immunology 2001;126(3):384-9.
2001: H Ando; Y Nishio; Katsuki Ito; Akimasa Nakao; L Wang; Ying Lan Zhao; Kiyoyuki Kitaichi; Kenji Takagi; Takaaki Hasegawa
Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats.
Antimicrobial agents and chemotherapy 2001;45(12):3462-7.
2001: Masayuki Nadai; Ying Lan Zhao; Li Wang; Y Nishio; Kenji Takagi; Kiyoyuki Kitaichi; K Takagi; Hideo Yoshizumi; Takaaki Hasegawa
Endotoxin impairs biliary transport of sparfloxacin and its glucuronide in rats.
European journal of pharmacology 2001;432(1):99-105.
2001: Kiyoyuki Kitaichi; Y Morishita; Takaaki Hasegawa
[Pharmacokinetic behavioral changes of methamphetamine in methamphetamine-sensitized animal model].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2001;21(5):133-44.
2001: Masahiro Yoshida; Tomoki Kimura; Kiyoyuki Kitaichi; Ritsuro Suzuki; Kenji Baba; Miyoko Matsushima; Yasuaki Tatsumi; Eiji Shibata; Kenji Takagi; Takaaki Hasegawa; K Takagi
Induction of histamine release from rat peritoneal mast cells by histatins.
Biological & pharmaceutical bulletin 2001;24(11):1267-70.
2001: Keiko Yokoyama; Yoshitsugu Iinuma; Yasushi Kawano; Miyo Nakano; Mika Kawagishi; T Yamashino; Takaaki Hasegawa; Michio Ohta
Resolution of Escherichia coli O157:H7 that contaminated radish sprouts in two outbreaks by two-dimensional gel electrophoresis.
Current microbiology 2001;43(5):311-5.
2001: Masahiro Yoshida; H Yoshida; Kiyoyuki Kitaichi; K Hiramatsu; Tomoki Kimura; Yasushi Ito; Hiroaki Kume; Kenichi Yamaki; Ritsuro Suzuki; Eiji Shibata; Takaaki Hasegawa; Kenji Takagi
Adrenomedullin and proadrenomedullin N-terminal 20 peptide induce histamine release from rat peritoneal mast cell.
Regulatory peptides 2001;101(1-3):163-8.
2001: Kumiko Kawamura-Sato; Y Iinuma; Takaaki Hasegawa; T Yamashino; Michio Ohta
Postantibiotic suppression effect of macrolides on the expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2001;7(1):51-4.
2001: Mitsunori Iwase; M Yokota; Kiyoyuki Kitaichi; L Wang; Kenji Takagi; T Nagasaka; H Izawa; Takaaki Hasegawa
Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor.
Critical care medicine 2001;29(3):609-17.
2001: Yasushi Kawano; Mika Kawagishi; Miyo Nakano; K Mase; T Yamashino; Takaaki Hasegawa; Michio Ohta
Proteolytic cleavage of staphylococcal exoproteins analyzed by two-dimensional gel electrophoresis.
Microbiology and immunology 2001;45(4):285-90.
2000: Kazumasa Naruhashi; Masayuki Nadai; M Nakao; Nagao Suzuki; Toshitaka Nabeshima; Takaaki Hasegawa
Changes in absorptive function of rat intestine injured by methotrexate.
Clinical and experimental pharmacology & physiology 2000;27(12):980-6.
2000: Keiko Yokoyama; Toshinobu Horii; Takafumi Yamashino; Shinnosuke Hashikawa; Soumitra Barua; Takaaki Hasegawa; H Watanabe; Michio Ohta
Production of shiga toxin by Escherichia coli measured with reference to the membrane vesicle-associated toxins.
FEMS microbiology letters 2000;192(1):139-44.
2000: Akio Itoh; T Shiotani; S Nakayama; Takayoshi Mamiya; Takaaki Hasegawa; Yukihiro Noda; Toshitaka Nabeshima
Attenuation of the development of morphine dependence/tolerance by nefiracetam: involvement of adenosine 3':5'-cyclic monophosphate system.
Behavioural brain research 2000;115(1):65-74.
2000: Kumiko Kawamura-Sato; Y Iinuma; Takaaki Hasegawa; Toshinobu Horii; T Yamashino; Michio Ohta
Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis.
Antimicrobial agents and chemotherapy 2000;44(10):2869-72.
2000: S Kiso; Shao Hui Cai; Kiyoyuki Kitaichi; N Furui; Kenji Takagi; K Takagi; Toshitaka Nabeshima; Takaaki Hasegawa
Inhibitory effect of erythromycin on P-glycoprotein-mediated biliary excretion of doxorubicin in rats.
Anticancer research 2000;20(5A):2827-34.
2000: Y Kawano; Y Ito; Y Yamakawa; Takafumi Yamashino; Toshinobu Horii; Takaaki Hasegawa; Michio Ohta
Rapid isolation and identification of staphylococcal exoproteins by reverse phase capillary high performance liquid chromatography-electrospray ionization mass spectrometry.
FEMS microbiology letters 2000;189(1):103-8.
2000: Li Wang; Kiyoyuki Kitaichi; C S Hui; Kenji Takagi; K Takagi; M Sakai; K Yokogawa; Ken-ichi Miyamoto; Takaaki Hasegawa
Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
Clinical and experimental pharmacology & physiology 2000;27(8):587-93.
2000: Toshinobu Horii; Keiko Yokoyama; Soumitra Barua; T Odagiri; N Futamura; Takaaki Hasegawa; Michio Ohta
The staphylokinase gene is located in the structural gene encoding N-acetylmuramyl-L-alanine amidase in methicillin-resistant Staphylococcus aureus.
FEMS microbiology letters 2000;185(2):221-4.
2000: K Mase; Takaaki Hasegawa; Toshinobu Horii; K Hatakeyama; Yasushi Kawano; T Yamashino; Michio Ohta
Firm adherence of Staphylococcus aureus and Staphylococcus epidermidis to human hair and effect of detergent treatment.
Microbiology and immunology 2000;44(8):653-6.
1999: Kiyoyuki Kitaichi; L Wang; Kenji Takagi; Mitsunori Iwase; E Shibata; Masayuki Nadai; Takaaki Hasegawa
Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.
Antimicrobial agents and chemotherapy 1999;43(11):2697-701.
1999: K Kitaichi; Yukihiro Noda; Yoshiaki Miyamoto; A Numaguchi; H Osawa; Takaaki Hasegawa; Hiroshi Furukawa; Toshitaka Nabeshima
Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats.
Behavioural brain research 1999;103(1):105-11.
1999: Takaaki Hasegawa; Kenji Takagi; Kiyoyuki Kitaichi
Effects of bacterial endotoxin on drug pharmacokinetics.
Nagoya journal of medical science 1999;62(1-2):11-28.
1998: S Kojima; Masayuki Nadai; Kiyoyuki Kitaichi; L Wang; T Nabeshima; Takaaki Hasegawa
Possible mechanism by which the carbapenem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats.
Antimicrobial agents and chemotherapy 1998;42(12):3136-40.
1998: Akio Itoh; Yukihiro Noda; Takayoshi Mamiya; Takaaki Hasegawa; Toshitaka Nabeshima
A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphine.
Methods and findings in experimental and clinical pharmacology 1998;20(7):619-25.
1998: Masayuki Nadai; I Matsuda; L Wang; A Itoh; Kazumasa Naruhashi; T Nabeshima; M Asai; Takaaki Hasegawa
Granulocyte colony-stimulating factor enhances endotoxin-induced decrease in biliary excretion of the antibiotic cefoperazone in rats.
Antimicrobial agents and chemotherapy 1998;42(9):2178-83.
1998: Masayuki Nadai; T Sekido; I Matsuda; W Li; Kiyoyuki Kitaichi; A Itoh; Toshitaka Nabeshima; Takaaki Hasegawa
Time-dependent effects of Klebsiella pneumoniae endotoxin on hepatic drug-metabolizing enzyme activity in rats.
The Journal of pharmacy and pharmacology 1998;50(8):871-9.
1998: T Kuzuya; Takaaki Hasegawa; Y Ogura; Toshitaka Nabeshima
Effect of transmucosal fluid movement on zinc and copper absorption from the rat small intestine.
Clinical and experimental pharmacology & physiology 1998;25(6):412-6.
1997: Ya-Ping Tang; Yukihiro Noda; Takaaki Hasegawa; Toshitaka Nabeshima
A concussive-like brain injury model in mice (II): selective neuronal loss in the cortex and hippocampus.
Journal of neurotrauma 1997;14(11):863-73.
1997: Ya-Ping Tang; Yukihiro Noda; Takaaki Hasegawa; Toshitaka Nabeshima
A concussive-like brain injury model in mice (I): impairment in learning and memory.
Journal of neurotrauma 1997;14(11):851-62.
1997: Takafumi Kuzuya; Takaaki Hasegawa; Rika Shiraki; Toshitaka Nabeshima
Structure-related pharmacokinetics of xanthines after direct administration into the peritoneal cavity of rats.
Biological & pharmaceutical bulletin 1997;20(10):1051-5.
1997: Ya-Ping Tang; Yukihiro Noda; Takaaki Hasegawa; Toshitaka Nabeshima
Effects of VA-045 on learning and memory deficits in traumatic brain injury (TBI)-induced retrograde and anterograde amnesic mice.
British journal of pharmacology 1997;122(2):257-64.
1997: Kazumasa Naruhashi; Kenji Kadomatsu; T Igakura; QW Fan; Naohiko Kuno; Hisako Muramatsu; T Miyauchi; Takaaki Hasegawa; Akio Itoh; Takashi Muramatsu; Toshitaka Nabeshima
Abnormalities of sensory and memory functions in mice lacking Bsg gene.
Biochemical and biophysical research communications 1997;236(3):733-7.
1997: Akio Itoh; Atsumi Nitta; Y Katono; M Usui; Kazumasa Naruhashi; R Iida; Takaaki Hasegawa; Toshitaka Nabeshima
Effects of metrifonate on memory impairment and cholinergic dysfunction in rats.
European journal of pharmacology 1997;322(1):11-9.
1997: Atsumi Nitta; Y Ogihara; Joji Onishi; Takaaki Hasegawa; Shoei Furukawa; Toshitaka Nabeshima
Oral administration of propentofylline, a stimulator of nerve growth factor (NGF) synthesis, recovers cholinergic neuronal dysfunction induced by the infusion of anti-NGF antibody into the rat septum.
Behavioural brain research 1997;83(1-2):201-4.
1997: Ya-Ping Tang; Yukihiro Noda; Takaaki Hasegawa; Toshitaka Nabeshima
(+)-Eburnamenine-14-carboxylic acid (2-nitroxyethyl) ester (VA-045), a putative cognitive enhancer, facilitates recovery from concussive brain injury-induced learning and memory impairments in mice.
Behavioural brain research 1997;83(1-2):195-9.
1997: Akio Itoh; Atsumi Nitta; M Hirose; Takaaki Hasegawa; Toshitaka Nabeshima
Effects of metrifonate on impairment of learning and dysfunction of cholinergic neuronal system in basal forebrain-lesioned rats.
Behavioural brain research 1997;83(1-2):165-7.
1997: Kiyofumi Yamada; Atsumi Nitta; Takaaki Hasegawa; K Fuji; M Hiramatsu; T Kameyama; Y Furukawa; K Hayashi; Toshitaka Nabeshima
Orally active NGF synthesis stimulators: potential therapeutic agents in Alzheimer's disease.
Behavioural brain research 1997;83(1-2):117-22.
1997: Atsumi Nitta; Tadashi Fukuta; Takaaki Hasegawa; Toshitaka Nabeshima
Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration.
Japanese journal of pharmacology 1997;73(1):51-7.
1996: Kiyoyuki Kitaichi; Yukihiro Noda; Takaaki Hasegawa; Hiroshi Furukawa; T Nabeshima
In vivo functional interaction between phencyclidine binding sites and sigma receptors to produce head-weaving behavior in rats.
European journal of pharmacology 1996;318(2-3):205-11.
1996: Kiyoyuki Kitaichi; Yukihiro Noda; Takaaki Hasegawa; Hiroshi Furukawa; T Nabeshima
Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats.
European journal of pharmacology 1996;318(1):7-9.
1996: M Shinoda; M Akita; M Hasegawa; Takaaki Hasegawa; T Nabeshima
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Biological & pharmaceutical bulletin 1996;19(8):1090-2.
1996: M Hasegawa; S Nakayama; H Kinoshita; M Amano; K Yamada; Takaaki Hasegawa; T Nabeshima
Effects of the subacute administration of nefiracetam on abnormal behavior in aged rats.
Behavioural brain research 1996;78(2):93-100.
1996: Masayuki Nadai; Takaaki Hasegawa; L Wang; S Haghgoo; T Okasaka; T Nabeshima; N Kato
Alterations in renal uptake kinetics of the xanthine derivative enprofylline in endotoxaemic mice.
The Journal of pharmacy and pharmacology 1996;48(7):744-8.
1996: Atsumi Nitta; Y Ogihara; J Onishi; Takaaki Hasegawa; S Furukawa; T Nabeshima
Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum.
European journal of pharmacology 1996;307(1):1-6.
1996: K Yamada; Yukihiro Noda; Y Komori; H Sugihara; Takaaki Hasegawa; T Nabeshima
Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats.
Neuroscience research 1996;24(4):393-402.
1996: Y Tsunekawa; Takaaki Hasegawa; Masayuki Nadai; Kenichi Yamaki; Kenji Takagi; T Nabeshima
Clinical application of the Biotrack 516 system for determination of theophylline by a turbidimetric latex agglutination inhibition reaction.
Therapeutic drug monitoring 1996;18(1):86-91.
1996: K Yamada; Yukihiro Noda; Takaaki Hasegawa; Yumiko Komori; Toshiaki Nikai; H Sugihara; T Nabeshima
The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice.
The Journal of pharmacology and experimental therapeutics 1996;276(2):460-6.
1996: M Hasegawa; K Yamada; Takaaki Hasegawa; T Nabeshima
Role of dopaminergic neuronal system in dizocilpine-induced acetylcholine release in the rat brain.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(6):651-60.
1995: Atsumi Nitta; Kazumasa Naruhashi; M Umemura; Takaaki Hasegawa; S Furukawa; F Sekiguchi; K Ishibashi; T Nabeshima
Age-related changes in learning and memory and cholinergic neuronal function in senescence accelerated mice (SAM).
Behavioural brain research 1995;72(1-2):49-55.
1995: Y Mizutani; Y Okada; M Ogawa; Takaaki Hasegawa; T Nabeshima
Pharmacokinetic model of oral levodopa and role of carbidopa in parkinsonian patients.
Biological & pharmaceutical bulletin 1995;18(12):1729-37.
1995: S Haghgoo; Takaaki Hasegawa; Masayuki Nadai; L Wang; T Nabeshima; N Kato
Effect of a bacterial lipopolysaccharide on biliary excretion of a beta-lactam antibiotic, cefoperazone, in rats.
Antimicrobial agents and chemotherapy 1995;39(10):2258-61.
1995: M Shinoda; M Akita; M Hasegawa; Masayuki Nadai; Takaaki Hasegawa; T Nabeshima
Pharmaceutical evaluation of carbamazepine suppositories in rats.
Biological & pharmaceutical bulletin 1995;18(9):1289-91.
1995: Takaaki Hasegawa; Masayuki Nadai; S Haghgoo; Kenichi Yamaki; Kenji Takagi; T Nabeshima
Influence of a newly developed quinolone, T-3761, on pharmacokinetics of theophylline in rats.
Antimicrobial agents and chemotherapy 1995;39(9):2138-40.
1995: Takaaki Hasegawa; Kenichi Yamaki; I Muraoka; Masayuki Nadai; Kenji Takagi; T Nabeshima
Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin.
Antimicrobial agents and chemotherapy 1995;39(9):2135-7.
1995: Masayuki Nadai; Takaaki Hasegawa; L Wang; S Haghgoo; T Nabeshima; N Kato
Time-dependent changes in the pharmacokinetics and renal excretion of xanthine derivative enprofylline induced by bacterial endotoxin in rats.
Biological & pharmaceutical bulletin 1995;18(8):1089-93.
1995: K Yamada; Yukihiro Noda; S Nakayama; Y Komori; H Sugihara; Takaaki Hasegawa; T Nabeshima
Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain.
British journal of pharmacology 1995;115(5):852-8.
1995: T A Nakamura; K Yamada; Takaaki Hasegawa; T Nabeshima
Possible involvement of nitric oxide in quinolinic acid-induced convulsion in mice.
Pharmacology, biochemistry, and behavior 1995;51(2-3):309-12.
1995: Takaaki Hasegawa; M Okuda; Masahiko Makino; Kenji Hiromatsu; K Nomoto; Yasunobu Yoshikai
Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.
International journal of immunopharmacology 1995;17(6):505-12.
1995: S Haghgoo; Takaaki Hasegawa; Masayuki Nadai; L Wang; T Ishigaki; Ken-ichi Miyamoto; T Nabeshima
Brain distribution characteristics of xanthine derivatives and relation to their locomotor activity in mice.
The Journal of pharmacy and pharmacology 1995;47(5):412-9.
1995: Y Maeda; K Yamada; Takaaki Hasegawa; T Nabeshima
Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-D-aspartate-induced aversive behavior.
European journal of pharmacology 1995;275(2):163-70.
1995: Ken-ichi Miyamoto; R Sakai; M Kurita; S Ohmae; F Sanae; H Sawanishi; Takaaki Hasegawa; Kenji Takagi
Effects of alkyl substituents of xanthine on phosphodiesterase isoenzymes.
Biological & pharmaceutical bulletin 1995;18(3):431-4.
1995: I Muraoka; Takaaki Hasegawa; Masayuki Nadai; L Wang; S Haghgoo; O Tagaya; T Nabeshima
Biliary and renal excretions of cefpiramide in Eisai hyperbilirubinemic rats.
Antimicrobial agents and chemotherapy 1995;39(1):70-4.
1995: Kiyoyuki Kitaichi; Y Minami; M Amano; K Yamada; Takaaki Hasegawa; T Nabeshima
The attenuation of suppression of motility by triazolam in the conditioned fear stress task is exacerbated by ethanol in mice.
Life sciences 1995;57(8):743-53.
1995: Kiyoyuki Kitaichi; K Yamada; Y Yoneda; K Ogita; Takaaki Hasegawa; Hiroshi Furukawa; T Nabeshima
Risperidone prevents the development of supersensitivity, but not tolerance, to phencyclidine in rats treated with subacute phencyclidine.
Life sciences 1995;56(7):531-43.
1994: Atsumi Nitta; Y Katono; Akio Itoh; Takaaki Hasegawa; T Nabeshima
Nicotine reverses scopolamine-induced impairment of performance in passive avoidance task in rats through its action on the dopaminergic neuronal system.
Pharmacology, biochemistry, and behavior 1994;49(4):807-12.
1994: Takaaki Hasegawa; Masayuki Nadai; L Wang; S Haghgoo; T Nabeshima; N Kato
Influence of endotoxin and lipid A on the renal handling and accumulation of gentamicin in rats.
Biological & pharmaceutical bulletin 1994;17(12):1651-5.
1994: Kiyoyuki Kitaichi; K Yamada; Takaaki Hasegawa; Hiroshi Furukawa; T Nabeshima
Effects of risperidone on phencyclidine-induced behaviors: comparison with haloperidol and ritanserin.
Japanese journal of pharmacology 1994;66(2):181-9.
1994: K Yamada; S Nakayama; T Shiotani; Takaaki Hasegawa; T Nabeshima
Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task.
The Journal of pharmacology and experimental therapeutics 1994;270(3):881-92.
1994: K Yamada; Toshio Hayashi; Takaaki Hasegawa; S Ishihara; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori; T Nabeshima
Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (2): changes in GABAA and benzodiazepine receptor binding.
Japanese journal of pharmacology 1994;66(1):53-8.
1994: S Ishihara; K Yamada; Toshio Hayashi; Takaaki Hasegawa; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori; T Nabeshima
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding.
Biological & pharmaceutical bulletin 1994;17(8):1132-4.
1994: T Kuzuya; M Yamauchi; A Ito; M Hasegawa; Takaaki Hasegawa; T Nabeshima
Pharmacokinetic characteristics of 5-fluorouracil and mitomycin C in intraperitoneal chemotherapy.
The Journal of pharmacy and pharmacology 1994;46(8):685-9.
1994: Masayuki Nadai; Takaaki Hasegawa; L Wang; O Tagaya; T Nabeshima
Alterations in the pharmacokinetics and protein binding of enprofylline in Eisai hyperbilirubinemic rats.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(4):561-5.
1994: Shuta Tomida; Takaaki Hasegawa; M Takeuchi; Norihiro Niimi; Minoru Ueda; T Kaneda; Toshiyuki Tanaka; T Tamatani; M Miyasaka; Yasunobu Yoshikai
Intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by CD3+TCR alpha beta- T cells at the early stage after infection with Listeria monocytogenes in rats.
International immunology 1994;6(7):955-61.
1994: H Kinoshita; Takaaki Hasegawa; T Kameyama; I Yamamoto; T Nabeshima
Competitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice.
Neuroscience letters 1994;174(1):101-4.
1994: T Maurice; M Hiramatsu; T Kameyama; Takaaki Hasegawa; T Nabeshima
Behavioral evidence for a modulating role of sigma ligands in memory processes. II. Reversion of carbon monoxide-induced amnesia.
Brain research 1994;647(1):57-64.
1994: T Maurice; M Hiramatsu; J Itoh; T Kameyama; Takaaki Hasegawa; T Nabeshima
Behavioral evidence for a modulating role of sigma ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia.
Brain research 1994;647(1):44-56.
1994: T Maurice; M Hiramatsu; T Kameyama; Takaaki Hasegawa; T Nabeshima
Cholecystokinin-related peptides, after systemic or central administration, prevent carbon monoxide-induced amnesia in mice.
The Journal of pharmacology and experimental therapeutics 1994;269(2):665-73.
1994: H Kinoshita; Takaaki Hasegawa; T Kameyama; T Nabeshima
Effects of vinconate on maze performance deficit induced by monoaminergic dysfunction in rats.
Research communications in chemical pathology and pharmacology 1994;84(2):175-87.
1994: Takaaki Hasegawa; M Okuda; K Nomoto; Yasunobu Yoshikai
Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice.
Immunopharmacology and immunotoxicology 1994;16(2):191-202.
1994: Atsumi Nitta; Y Murakami; Y Furukawa; W Kawatsura; K Hayashi; K Yamada; Takaaki Hasegawa; T Nabeshima
Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(4):401-7.
1994: Toshio Hayashi; K Yamada; Takaaki Hasegawa; S Ishihara; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori; T Nabeshima
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (1): Changes in the [3H]QNB binding.
Japanese journal of pharmacology 1994;64(4):303-6.
1994: T Nabeshima; S Nakayama; K Ichihara; K Yamada; T Shiotani; Takaaki Hasegawa
Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task.
European journal of pharmacology 1994;255(1-3):57-65.
1994: T Maurice; M Hiramatsu; J Itoh; T Kameyama; Takaaki Hasegawa; T Nabeshima
Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice.
Psychopharmacology 1994;114(3):520-2.
1994: Atsumi Nitta; Akio Itoh; Takaaki Hasegawa; T Nabeshima
beta-Amyloid protein-induced Alzheimer's disease animal model.
Neuroscience letters 1994;170(1):63-6.
1994: I Muraoka; Takaaki Hasegawa; Masayuki Nadai; L Wang; O Tagaya; T Nabeshima
Influence of age on the disposition and renal handling of enprofylline in rats.
The Journal of pharmacy and pharmacology 1994;46(3):230-4.
1994: K Yamada; T Teraoka; S Morita; Takaaki Hasegawa; T Nabeshima
Omega-conotoxin GVIA protects against ischemia-induced neuronal death in the Mongolian gerbil but not against quinolinic acid-induced neurotoxicity in the rat.
Neuropharmacology 1994;33(2):251-4.
1994: Takaaki Hasegawa; Kenichi Yamaki; Masayuki Nadai; I Muraoka; L Wang; Kenji Takagi; T Nabeshima
Lack of effect of Chinese medicines on bioavailability of ofloxacin in healthy volunteers.
International journal of clinical pharmacology and therapeutics 1994;32(2):57-61.
1994: K Yamada; T Teraoka; S Morita; Takaaki Hasegawa; T Nabeshima
Omega-conotoxin GVIA inhibits the methylphenidate-induced but not methamphetamine-induced behavior.
Neuroscience letters 1994;165(1-2):191-4.
1994: Y Maeda; K Yamada; Takaaki Hasegawa; Y Kawamata; K Uchida; M Iyo; S Fukui; T Nabeshima
Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E2 in mice.
Research communications in chemical pathology and pharmacology 1994;83(1):15-24.
1994: Takaaki Hasegawa; Masayuki Nadai; L Wang; Y Takayama; K Kato; T Nabeshima; N Kato
Renal excretion of famotidine and role of adenosine in renal failure induced by bacterial lipopolysaccharide in rats.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):8-13.
1994: Atsumi Nitta; Y Furukawa; K Hayashi; Takaaki Hasegawa; T Nabeshima
Nerve growth factor content of rat brain increases following basal-forebrain lesions induced by ibotenic acid but not by electrolysis.
Biological & pharmaceutical bulletin 1994;17(1):34-8.
1994: Takaaki Hasegawa; Kenji Takagi; Masayuki Nadai; Y Ogura; T Nabeshima
Kinetic interaction between theophylline and a newly developed anti-allergic drug, pemirolast potassium.
European journal of clinical pharmacology 1994;46(1):55-8.
1994: T Nabeshima; K Yamada; Toshio Hayashi; Takaaki Hasegawa; S Ishihara; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori
Changes in muscarinic cholinergic, PCP, GABAA, D1, and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats.
Life sciences 1994;55(20):1585-93.
1994: T Nabeshima; Atsumi Nitta; K Fuji; T Kameyama; Takaaki Hasegawa
Oral administration of NGF synthesis stimulators recovers reduced brain NGF content in aged rats and cognitive dysfunction in basal-forebrain-lesioned rats.
Gerontology 1994;40 Suppl 2():46-56.
1994: T Nabeshima; A Itoh; K Kobayashi; S Morita; T Mizuguchi; H Sawada; Atsumi Nitta; Takaaki Hasegawa; K Hayashi; Toshiharu Nagatsu
Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene.
Journal of neural transmission. General section 1994;97(1):41-9.
1994: H Kinoshita; Takaaki Hasegawa; Y Katsumata; T Kameyama; I Yamamoto; T Nabeshima
Effect of dizocilpine (MK-801) on the catalepsy induced by delta 9-tetrahydrocannabinol in mice.
Journal of neural transmission. General section 1994;95(2):137-43.
1994: Y Maeda; K Yamada; Takaaki Hasegawa; M Iyo; S Fukui; T Nabeshima
Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids.
Journal of neural transmission. General section 1994;96(2):125-33.
1993: Atsumi Nitta; Takaaki Hasegawa; T Nabeshima
Oral administration of idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain.
Neuroscience letters 1993;163(2):219-22.
1993: M Amano; M Hasegawa; Takaaki Hasegawa; T Nabeshima
Characteristics of transient cerebral ischemia-induced deficits on various learning and memory tasks in male Mongolian gerbils.
Japanese journal of pharmacology 1993;63(4):469-77.
1993: K Yamada; T Teraoka; S Morita; Takaaki Hasegawa; T Nabeshima
Neuropharmacological characterization of voltage-sensitive calcium channels: possible existence of neomycin-sensitive, omega-conotoxin GVIA- and dihydropyridines-resistant calcium channels in the rat brain.
Japanese journal of pharmacology 1993;63(4):423-32.
1993: Atsumi Nitta; K Murase; Y Furukawa; K Hayashi; Takaaki Hasegawa; T Nabeshima
Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats.
Neuroscience 1993;57(3):495-9.
1993: Atsumi Nitta; K Murase; Y Furukawa; K Hayashi; Takaaki Hasegawa; T Nabeshima
Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats.
European journal of pharmacology 1993;250(1):23-30.
1993: T Nabeshima; Y Maeda; K Yamada; T Nakamura; Takaaki Hasegawa
The inhibitory effects of salmon calcitonin on intrathecally-injected N-methyl-D-aspartate-induced aversive behavior in mice.
Research communications in chemical pathology and pharmacology 1993;82(2):175-84.
1993: Masayuki Nadai; Takaaki Hasegawa; K Kato; L Wang; T Nabeshima; N Kato
Influence of a bacterial lipopolysaccharide on the pharmacokinetics of tobramycin in rats.
The Journal of pharmacy and pharmacology 1993;45(11):971-4.
1993: Masayuki Nadai; Takaaki Hasegawa; K Kato; L Wang; T Nabeshima; N Kato
Alterations in pharmacokinetics and protein binding behavior of cefazolin in endotoxemic rats.
Antimicrobial agents and chemotherapy 1993;37(9):1781-5.
1993: Takaaki Hasegawa; Ken-Ichi Isobe; I Nakashima; Kaoru Shimokata
Higher expression of topoisomerase II in lung cancers than normal lung tissues: different expression pattern from topoisomerase I.
Biochemical and biophysical research communications 1993;195(1):409-14.
1993: L Wang; Takaaki Hasegawa; Masayuki Nadai; T Nabeshima
The effects of N-benzoyl-beta-alanine, a new nephroprotective drug, on the distribution and renal excretion of enprofylline in rats.
The Journal of pharmacy and pharmacology 1993;45(7):622-6.
1993: Masayuki Nadai; Takaaki Hasegawa; K Kato; L Wang; T Nabeshima; N Kato
The disposition and renal handling of enprofylline in endotoxemic rats by bacterial lipopolysaccharide (LPS).
Drug metabolism and disposition: the biological fate of chemicals 1993;21(4):611-6.
1993: Y Hasegawa; Nobuhiko Emi; Kaoru Shimokata; Akihiro Abe; T Kawabe; Takaaki Hasegawa; T Kirioka; H Saito
Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors.
American journal of respiratory cell and molecular biology 1993;8(6):655-61.
1993: T Nabeshima; Atsumi Nitta; Takaaki Hasegawa
Impairment of learning and memory and the accessory symptom in aged rat as senile dementia model (3): Oral administration of propentofylline produces recovery of reduced NGF content in the brain of aged rats.
Yakubutsu, seishin, kōdō = Japanese journal of psychopharmacology 1993;13(3):89-95.
1993: Ken-ichi Miyamoto; Y Yamamoto; M Kurita; R Sakai; K Konno; F Sanae; T Ohshima; Kenji Takagi; Takaaki Hasegawa; N Iwasaki
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
Journal of medicinal chemistry 1993;36(10):1380-6.
1993: T Nabeshima; M Hasegawa; S Nakayama; H Kinoshita; M Amano; Takaaki Hasegawa
[Impairment of learning and memory and the accessory symptom in aged rats as senile dementia model (2)--Learning and memory].
Yakubutsu, seishin, kōdō = Japanese journal of psychopharmacology 1993;13(2):73-9.
1993: T Nabeshima; M Hasegawa; S Nakayama; H Kinoshita; M Amano; Takaaki Hasegawa
[Impairment of learning and memory and the accessory symptom in aged rats as senile dementia model (1)--Emotional behavior].
Yakubutsu, seishin, kōdō = Japanese journal of psychopharmacology 1993;13(2):65-72.
1993: Ken-ichi Miyamoto; K Inoko; S Wakusawa; S Kajita; Takaaki Hasegawa; Kenji Takagi; M Koyama
Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.
Cancer research 1993;53(7):1555-9.
1993: M Amano; A Goto; N Takahashi; Takaaki Hasegawa; T Nabeshima
Effects of BMY-21502 on anoxia in mice.
Japanese journal of pharmacology 1993;61(3):157-63.
1993: M Hasegawa; H Kinoshita; M Amano; Takaaki Hasegawa; T Kameyama; T Nabeshima
MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis.
Neuroscience letters 1993;150(1):53-6.
1993: T Kuzuya; Takaaki Hasegawa; K Shimizu; T Nabeshima
Effect of anti-epileptic drugs on serum zinc and copper concentrations in epileptic patients.
International journal of clinical pharmacology, therapy, and toxicology 1993;31(2):61-5.
1993: S Wakusawa; K Inoko; Ken-ichi Miyamoto; S Kajita; Takaaki Hasegawa; K Harimaya; M Koyama
Staurosporine derivatives reverse multidrug resistance without correlation with their protein kinase inhibitory activities.
The Journal of antibiotics 1993;46(2):353-5.
1993: Atsumi Nitta; K Hayashi; Takaaki Hasegawa; T Nabeshima
Development of plasticity of brain function with repeated trainings and passage of time after basal forebrain lesions in rats.
Journal of neural transmission. General section 1993;93(1):37-46.
1993: Ken-ichi Miyamoto; K Inoko; K Ikeda; S Wakusawa; S Kajita; Takaaki Hasegawa; Kenji Takagi; M Koyama
Effect of staurosporine derivatives on protein kinase activity and vinblastine accumulation in mouse leukaemia P388/ADR cells.
The Journal of pharmacy and pharmacology 1993;45(1):43-7.
1993: L Wang; Takaaki Hasegawa; Masayuki Nadai; I Muraoka; T Nabeshima; N Kato
The effect of lipopolysaccharide on the disposition of xanthines in rats.
The Journal of pharmacy and pharmacology 1993;45(1):34-8.
1992: Ken-ichi Miyamoto; R Sakai; Y Yamamoto; K Konno; F Sanae; Takaaki Hasegawa; Kenji Takagi
Selective bronchodilators from 1-(5'-oxohexyl)xanthines.
The Journal of pharmacy and pharmacology 1992;44(11):888-92.
1992: R Sakai; K Konno; Y Yamamoto; F Sanae; Kenji Takagi; Takaaki Hasegawa; N Iwasaki; M Kakiuchi; H Kato; Ken-ichi Miyamoto
Effects of alkyl substitutions of xanthine skeleton on bronchodilation.
Journal of medicinal chemistry 1992;35(22):4039-44.
1992: Takaaki Hasegawa; Toshiyuki Tanaka; Yasunobu Yoshikai
The appearance and role of gamma delta T cells in the peritoneal cavity and liver during primary infection with Listeria monocytogenes in rats.
International immunology 1992;4(10):1129-36.
1992: Masayuki Nadai; R Apichartpichean; Takaaki Hasegawa; T Nabeshima
Pharmacokinetics and the effect of probenecid on the renal excretion mechanism of diprophylline.
Journal of pharmaceutical sciences 1992;81(10):1024-7.
1992: Atsumi Nitta; Y Furukawa; K Hayashi; M Hiramatsu; T Kameyama; Takaaki Hasegawa; T Nabeshima
Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain.
Neuroscience letters 1992;144(1-2):152-6.
1992: I Muraoka; Takaaki Hasegawa; Masayuki Nadai; K Kato; T Nabeshima
Pharmacokinetics and renal handling of enprofylline in pregnant rats.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):653-7.
1992: Y Maeda; T Nakamura; Takaaki Hasegawa; H Furukawa; T Nabeshima
Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid.
Research communications in chemical pathology and pharmacology 1992;77(2):191-9.
1992: Y Tsunekawa; Takaaki Hasegawa; Masayuki Nadai; Kenji Takagi; T Nabeshima
Interspecies differences and scaling for the pharmacokinetics of xanthine derivatives.
The Journal of pharmacy and pharmacology 1992;44(7):594-9.
1992: Kenji Takagi; Takaaki Hasegawa; Masayuki Nadai; R Sakai; Ken-ichi Miyamoto
Bronchodilatory activity and pharmacokinetics of new xanthines in guinea-pigs.
Clinical and experimental pharmacology & physiology 1992;19(6):447-56.
1992: H Kinoshita; T Kameyama; Takaaki Hasegawa; T Nabeshima
Effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by the basal forebrain lesion in rats.
Pharmacology, biochemistry, and behavior 1992;42(1):19-23.
1992: Kenji Takagi; Takaaki Hasegawa; Kenichi Yamaki; K Suzuki; T Nabeshima
Secretion of ofloxacin into saliva in patients with respiratory tract infection.
International journal of clinical pharmacology, therapy, and toxicology 1992;30(2):46-50.
1992: H Kinoshita; T Kameyama; Takaaki Hasegawa; T Nabeshima
Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats.
Life sciences 1992;51(4):267-73.
1991: T Ohshima; Takaaki Hasegawa; I Johno; S Kitazawa
Protein binding of cefpiramide in the plasma of various species.
The Journal of pharmacy and pharmacology 1991;43(11):805-6.
1991: Takaaki Hasegawa; Masayuki Nadai; R Apichartpichean; I Muraoka; T Nabeshima; Kenji Takagi
Pharmacokinetic characteristics of N7-substituted theophylline derivatives and their interaction with quinolone in rats.
Journal of pharmaceutical sciences 1991;80(10):962-5.
1991: Takaaki Hasegawa; T Kuzuya; R Apichartpichean; Masayuki Nadai; Atsumi Nitta; Kenji Takagi; T Nabeshima
Structure-related inhibitory effect of quinolones on alkyl-xanthine elimination in rats.
Pharmacology & toxicology 1991;69(1):5-8.
1991: Masayuki Nadai; Takaaki Hasegawa; I Muraoka; Kenji Takagi; T Nabeshima
Dose-dependent pharmacokinetics of enprofylline and its renal handling in rats.
Journal of pharmaceutical sciences 1991;80(7):648-52.
1991: Kenji Takagi; Kenichi Yamaki; Masayuki Nadai; T Kuzuya; Takaaki Hasegawa
Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients.
Antimicrobial agents and chemotherapy 1991;35(6):1137-41.
1991: R Apichartpichean; Takaaki Hasegawa; Masayuki Nadai; T Kuzuya; T Nabeshima
Structure-pharmacokinetic relationships among the N1,N3-alkylxanthines in rats.
The Journal of pharmacy and pharmacology 1991;43(4):262-9.
1991: Takaaki Hasegawa; Kenji Takagi; Masayuki Nadai; Ken-ichi Miyamoto
Protein binding of xanthine derivatives to guinea pig serum albumin.
Journal of pharmaceutical sciences 1991;80(4):349-52.
1990: Takaaki Hasegawa; Masayuki Nadai; T Kuzuya; I Muraoka; R Apichartpichean; Kenji Takagi; Ken-ichi Miyamoto
The possible mechanism of interaction between xanthines and quinolone.
The Journal of pharmacy and pharmacology 1990;42(11):767-72.
1990: Masayuki Nadai; Takaaki Hasegawa; T Kuzuya; I Muraoka; Kenji Takagi; H Yoshizumi
Effects of enoxacin on renal and metabolic clearance of theophylline in rats.
Antimicrobial agents and chemotherapy 1990;34(9):1739-43.
1990: Masayuki Nadai; H Yoshizumi; T Kuzuya; Takaaki Hasegawa; I Johno; S Kitazawa
Effect of diabetes on disposition and renal handling of cefazolin in rats.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):565-70.
1990: Takaaki Hasegawa; Kenji Takagi; T Kuzuya; Masayuki Nadai; R Apichartpichean; I Muraoka
Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.
European journal of clinical pharmacology 1990;38(3):255-8.
1990: T Ohshima; I Johno; Takaaki Hasegawa; S Kitazawa
Direct determination of protein binding of phenytoin in serum by high-performance liquid chromatography.
Journal of pharmaceutical sciences 1990;79(1):77-81.
1989: Ken-Ichi Isobe; Y Hasegawa; T Iwamoto; Takaaki Hasegawa; K Kawashima; L N Ding; I Nakashima
Induction of antitumor immunity in mice by allo-major histocompatibility complex class I gene transfectant with strong antigen expression.
Journal of the National Cancer Institute 1989;81(23):1823-8.
1989: Ken-ichi Miyamoto; Kenji Takagi; R Sakai; S Wakusawa; R Koshiura; Masayuki Nadai; R Apichartpichean; Takaaki Hasegawa
Correlation between hydrophobicity of N-alkylxanthine derivatives and their biological activities on guinea-pig isolated tracheal smooth muscle.
The Journal of pharmacy and pharmacology 1989;41(12):844-7.
1989: T Ohshima; Takaaki Hasegawa; I Johno; S Kitazawa
Variations in protein binding of drugs in plasma and serum.
Clinical chemistry 1989;35(8):1722-5.
1989: R Apichartpichean; Kenji Takagi; T Kuzuya; Masayuki Nadai; T Ohshima; K Suzuki; T Horiuchi; Ken-ichi Miyamoto; Takaaki Hasegawa
Protein binding characteristics of a new bronchodilator, 1-methyl-3-propylxanthine (MPX), in different species.
International journal of clinical pharmacology, therapy, and toxicology 1989;27(7):320-3.
1989: T Kuzuya; Kenji Takagi; R Apichartpichean; I Muraoka; Masayuki Nadai; Takaaki Hasegawa
Kinetic interaction between theophylline and a newly developed quinolone, NY-198.
Journal of pharmacobio-dynamics 1989;12(7):405-9.
1989: T Horiuchi; I Johno; Takaaki Hasegawa; S Kitazawa; M Goto; T Hata
Inhibitory effect of free fatty acids on plasma protein binding of disopyramide in haemodialysis patients.
European journal of clinical pharmacology 1989;36(2):175-80.
1989: Kenji Takagi; T Kuzuya; T Horiuchi; Masayuki Nadai; R Apichartpichean; Y Ogura; Takaaki Hasegawa
Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients.
European journal of clinical pharmacology 1989;37(3):301-3.
1988: A Ruttikorn; Kenji Takagi; Masayuki Nadai; T Kuzuya; K Ogawa; Ken-ichi Miyamoto; Takaaki Hasegawa
Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX).
Japanese journal of pharmacology 1988;48(3):341-7.
1988: Kenji Takagi; Takaaki Hasegawa; Kenichi Yamaki; Ryujiro Suzuki; T Watanabe; T Satake
Interaction between theophylline and enoxacin.
International journal of clinical pharmacology, therapy, and toxicology 1988;26(6):288-92.
1988: Kenji Takagi; Takaaki Hasegawa; T Kuzuya; K Ogawa; T Watanabe; T Satake; Ken-ichi Miyamoto; S Wakusawa; R Koshiura
Structure-activity relationship in N3-alkyl-xanthine derivatives.
Japanese journal of pharmacology 1988;46(4):373-8.
1988: Kenji Takagi; Takaaki Hasegawa; Y Ogura; Ryujiro Suzuki; Kenichi Yamaki; T Watanabe; S Kitazawa; T Satake
Comparative studies on interaction between theophylline and quinolones.
The Journal of asthma : official journal of the Association for the Care of Asthma 1988;25(2):63-71.
1987: Kenji Takagi; Takaaki Hasegawa; Y Ogura; Kenichi Yamaki; Ryujiro Suzuki; T Satake; N Imaeda; Y Mizukami
Absorption of theophylline from a sustained-release theophylline tablet formulation, Theo-Dur.
International journal of clinical pharmacology, therapy, and toxicology 1987;25(10):530-5.
1987: Kenji Takagi; T Satake; Takaaki Hasegawa; Ken-ichi Miyamoto; S Wakusawa; T Matsunaga; R Koshiura
Multiform combination effects of smooth muscle relaxants with antitumor agents in rat ascites hepatoma AH66 cells.
Japanese journal of pharmacology 1987;45(1):69-77.