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Keitaro Hashimoto

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Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Hiroshi Iwasaki; Yuji Nakamura; Keitaro Hashimoto
Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods.
Keitaro Hashimoto
Arrhythmia models for drug research: classification of antiarrhythmic drugs.
Kentaro Ando; Atsushi Sugiyama; Akira Takahara; Yoshioki Satoh; Tomomichi Ishizaka; Yuji Nakamura; Keitaro Hashimoto
Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs.

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2007: Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Hiroshi Iwasaki; Yuji Nakamura; Keitaro Hashimoto
Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods.
Basic & clinical pharmacology & toxicology 2007;101(1):35-40.
2007: Keitaro Hashimoto
Arrhythmia models for drug research: classification of antiarrhythmic drugs.
Journal of pharmacological sciences 2007;103(4):333-46.
2007: Kentaro Ando; Atsushi Sugiyama; Akira Takahara; Yoshioki Satoh; Tomomichi Ishizaka; Yuji Nakamura; Keitaro Hashimoto
Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs.
European journal of pharmacology 2007;558(1-3):151-8.
2007: Jianguang Chen; Hua Shen; Yoshinobu Nagasawa; Kazuhiro Mitsui; Kunio Tsurugi; Keitaro Hashimoto
Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats.
Journal of pharmacological sciences 2007;103(3):317-22.
2007: Akira Takahara; Hideki Nakamura; Hideaki Nouchi; Takeshi Tamura; Toshikazu Tanaka; Hideaki Shimada; Miku Tamura; Noriko Tsuruoka; Kentaro Takeda; Hikaru Tanaka; Koki Shigenobu; Keitaro Hashimoto; Atsushi Sugiyama
Analysis of arrhythmogenic profile in a canine model of chronic atrioventricular block by comparing in vitro effects of the class III antiarrhythmic drug nifekalant on the ventricular action potential indices between normal heart and atrioventricular block heart.
Journal of pharmacological sciences 2007;103(2):181-8.
2006: Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Keitaro Hashimoto
Comparison of four rate-correction algorithms for the ventricular repolarization period in assessing net effects of IKr blockers in dogs.
Journal of pharmacological sciences 2006;102(4):396-404.
2006: Nobuo Homma; Md Shah Amran; Yoshinobu Nagasawa; Keitaro Hashimoto
Topics on the Na+/Ca2+ exchanger: involvement of Na+/Ca2+ exchange system in cardiac triggered activity.
Journal of pharmacological sciences 2006;102(1):17-21.
2006: Akira Takahara; Atsushi Sugiyama; Keitaro Hashimoto
Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation.
Biological & pharmaceutical bulletin 2006;29(4):827-9.
2006: Akira Takahara; Atsushi Sugiyama; Yuko Ishida; Yoshioki Satoh; Kai Wang; Yuji Nakamura; Keitaro Hashimoto
Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias.
British journal of pharmacology 2006;147(6):634-41.
2005: Yasue Sakaguchi; Atsushi Sugiyama; Shuji Takao; Yasuki Akie; Akira Takahara; Keitaro Hashimoto
Halothane sensitizes the guinea-pig heart to pharmacological IKr blockade: comparison with urethane anesthesia.
Journal of pharmacological sciences 2005;99(2):185-90.
2005: Akira Takahara; Atsushi Sugiyama; Keitaro Hashimoto
Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation.
British journal of pharmacology 2005;146(4):561-7.
2005: Chikaomi Yamada; YiXue Xue; Daisuke Chino; Keitaro Hashimoto
Effects of KB-R9032, a new Na+/H+ exchange inhibitor, on canine coronary occlusion/reperfusion-induced ventricular arrhythmias.
Journal of pharmacological sciences 2005;98(4):404-10.
2005: Sachiko Honsho; Atsushi Sugiyama; Akira Takahara; Yoshioki Satoh; Yuji Nakamura; Keitaro Hashimoto
A red wine vinegar beverage can inhibit the renin-angiotensin system: experimental evidence in vivo.
Biological & pharmaceutical bulletin 2005;28(7):1208-10.
2005: Atsushi Sugiyama; Akira Takahara; Sachiko Honsho; Yuji Nakamura; Keitaro Hashimoto
A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.
Journal of pharmacological sciences 2005;98(3):315-8.
2005: Atsushi Sugiyama; Yoshioki Satoh; Akira Takahara; Kentaro Ando; Yuji Nakamura; Keitaro Hashimoto
Comparison of the direct negative dromotropic effect of a new calcium channel blocker, cilnidipine, with that of nicardipine.
Heart and vessels 2005;20(3):112-5.
2005: Akira Takahara; Atsushi Sugiyama; Sachiko Honsho; Yasue Sakaguchi; Yasuki Akie; Yuji Nakamura; Keitaro Hashimoto
The endothelium-dependent vasodilator action of a new beverage made of red wine vinegar and grape juice.
Biological & pharmaceutical bulletin 2005;28(4):754-6.
2005: Yoshinobu Nagasawa; Jianguang Chen; Keitaro Hashimoto
Antiarrhythmic properties of a prior oral loading of amiodarone in in vivo canine coronary ligation/reperfusion-induced arrhythmia model: comparison with other class III antiarrhythmic drugs.
Journal of pharmacological sciences 2005;97(3):393-9.
2005: Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Kai Wang; Sachiko Honsho; Keitaro Hashimoto
Halothane sensitizes the canine heart to pharmacological IKr blockade.
European journal of pharmacology 2005;507(1-3):169-77.
2005: Yoshinobu Nagasawa; Bing-Mei Zhu; Jianguang Chen; Kazunori Kamiya; Shigeki Miyamoto; Keitaro Hashimoto
Effects of SEA0400, a Na+/Ca2+ exchange inhibitor, on ventricular arrhythmias in the in vivo dogs.
European journal of pharmacology 2005;506(3):249-55.
2005: Yoshioki Satoh; Atsushi Sugiyama; Akira Takahara; Kentaro Ando; Kai Wang; Sachiko Honsho; Keitaro Hashimoto
The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart.
Journal of pharmacological sciences 2005;97(1):101-6.
2004: Atsushi Sugiyama; Yoshioki Satoh; Akira Takahara; Kentaro Ando; Kai Wang; Sachiko Honsho; Yuji Nakamura; Keitaro Hashimoto
Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model.
Journal of pharmacological sciences 2004;96(4):436-43.
2004: Md Shah Amran; Keitaro Hashimoto; Nobuo Homma
Effects of sodium-calcium exchange inhibitors, KB-R7943 and SEA0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies.
The Journal of pharmacology and experimental therapeutics 2004;310(1):83-9.
2004: Yoshiaki Noda; Keitaro Hashimoto
Development of a halothane-adrenaline arrhythmia model using in vivo Guinea pigs.
Journal of pharmacological sciences 2004;95(2):234-9.
2004: Yoshioki Satoh; Atsushi Sugiyama; Akira Takahara; Katsuyoshi Chiba; Keitaro Hashimoto
Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models.
Journal of cardiovascular pharmacology 2004;43(5):715-23.
2004: Akira Takahara; Atsushi Sugiyama; Keitaro Hashimoto
Effects of class I antiarrhythmic drugs on the digitalis-induced triggered activity arrhythmia model: a rationale for the short-term use of class I drugs against triggered arrhythmias.
Heart and vessels 2004;19(1):43-8.
2003: Bing-Mei Zhu; Shigeki Miyamoto; Yoshinobu Nagasawa; Teruaki Wajima; Keitaro Hashimoto
Effect of the sarcolemmal K(ATP) channel blocker HMR1098 on arrhythmias induced by programmed electrical stimulation in canine old myocardial infarction model: comparison with glibenclamide.
Journal of pharmacological sciences 2003;93(1):106-13.
2003: Jianguang Chen; Yoshinobu Nagasawa; Bing-Mei Zhu; Masami Ohmori; Ken-ichi Harada; Akio Fujimura; Keitaro Hashimoto
Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats.
Journal of pharmacological sciences 2003;93(1):87-94.
2003: Yoshiki Saegusa; Atsushi Sugiyama; Akira Takahara; Yoshinobu Nagasawa; Keitaro Hashimoto
Relationship between phosphodiesterase inhibition induced by several Kampo medicines and smooth muscle relaxation of gastrointestinal tract tissues of rats.
Journal of pharmacological sciences 2003;93(1):62-8.
2003: Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Keitaro Hashimoto
Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.
European journal of pharmacology 2003;476(1-2):115-22.
2003: Atsushi Sugiyama; Akira Takahara; Yutaka Yatomi; Yoshioki Satoh; Yuji Nakamura; Keitaro Hashimoto
Constitutional rho-kinase regulates atrioventricular nodal conduction and ventricular repolarization of the canine heart.
Journal of cardiovascular pharmacology 2003;41(6):930-3.
2003: Atsushi Sugiyama; Yoshioki Satoh; Akira Takahara; Yuji Nakamura; Masao Shimizu-Sasamata; Shuichi Sato; Keiji Miyata; Keitaro Hashimoto
Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems.
European journal of pharmacology 2003;466(1-2):137-46.
2003: Akira Takahara; Atsushi Sugiyama; Yoshioki Satoh; Masahiko Yoneyama; Keitaro Hashimoto
Cardiovascular effects of Y-27632, a selective Rho-associated kinase inhibitor, assessed in the halothane-anesthetized canine model.
European journal of pharmacology 2003;460(1):51-7.
2003: Bing-Mei Zhu; Shigeki Miyamoto; Yoshinobu Nagasawa; Masaki Saitoh; Sadayoshi Komori; Keitaro Hashimoto
Does Cl-/HCO3- exchange play an important role in reperfusion arrhythmias in rats?
European journal of pharmacology 2003;460(1):43-50.
2003: Md Shah Amran; Nobuo Homma; Keitaro Hashimoto
Pharmacology of KB-R7943: a Na+-Ca2+ exchange inhibitor.
Cardiovascular drug reviews 2003;21(4):255-76.
2002: Masahiko Yoneyama; Atsushi Sugiyama; Yoshioki Satoh; Akira Takahara; Yuji Nakamura; Keitaro Hashimoto
Cardiovascular and adenylate cyclase stimulating effects of colforsin daropate, a water-soluble forskolin derivative, compared with those of isoproterenol, dopamine and dobutamine.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(12):1150-4.
2002: Shigeki Miyamoto; Bing-Mei Zhu; Kazunori Kamiya; Yoshinobu Nagasawa; Keitaro Hashimoto
KB-R7943, a Na+/Ca2+ exchange inhibitor, does not suppress ischemia/reperfusion arrhythmias nor digitalis arrhythmias in dogs.
Japanese journal of pharmacology 2002;90(3):229-35.
2002: Hiroshi Yoshida; Atsushi Sugiyama; Yoshioki Satoh; Yuko Ishida; Kiyotaka Kugiyama; Keitaro Hashimoto
Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(9):857-62.
2002: Hiroshi Yoshida; Atsushi Sugiyama; Yoshioki Satoh; Yuko Ishida; Masahiko Yoneyama; Kiyotaka Kugiyama; Keitaro Hashimoto
Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(8):758-62.
2002: Atsushi Sugiyama; Yoshioki Satoh; Hiroyuki Shiina; Satoshi Takeda; Keitaro Hashimoto
Torsadegenic action of the antipsychotic drug sulpiride assessed using in vivo canine models.
Journal of cardiovascular pharmacology 2002;40(2):235-45.
2002: Masaki Saitoh; Atsushi Sugiyama; Tomoo Nakazawa; Keitaro Hashimoto
Cardiovascular effects of orally administered HNS-32, an originally synthesized azulene-1-carboxamidine derivative, assessed in the in vivo rat model.
Japanese journal of pharmacology 2002;89(3):316-9.
2002: Atsushi Sugiyama; Yoshioki Satoh; Yuko Ishida; Masahiko Yoneyama; Hiroshi Yoshida; Keitaro Hashimoto
Pharmacological and electrophysiological characterization of junctional rhythm during radiofrequency catheter ablation of the atrioventricular node: possible involvement of neurotransmitters from autonomic nervous system.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(7):696-701.
2002: Masahiko Yoneyama; Atsushi Sugiyama; Hiroshi Yoshida; Yoshioki Satoh; Keitaro Hashimoto
Cardiovascular effects of L-158,809, a new angiotensin type 1 receptor antagonist, assessed using the halothane-anesthetized in vivo canine model.
Japanese journal of pharmacology 2002;89(2):192-6.
2002: Atsushi Sugiyama; Keitaro Hashimoto
Effects of a typical I(Kr) channel blocker sematilide on the relationship between ventricular repolarization, refractoriness and onset of torsades de pointes.
Japanese journal of pharmacology 2002;88(4):414-21.
2002: Atsushi Sugiyama; Nobuyasu Takeuchi; Yoshiki Saegusa; Masao Sugita; Keitaro Hashimoto
Molecular mechanisms of cardiostimulatory effects of sildenafil.
Japanese journal of pharmacology 2002;88(3):362-4.
2002: Atsushi Sugiyama; Yutaka Yatomi; Akira Takahara; Yoshioki Satoh; Keitaro Hashimoto
Cardiac effects of a selective rho-associated kinase inhibitor, Y-27632, assessed in canine isolated, blood-perfused heart preparations.
Japanese journal of pharmacology 2002;88(3):359-61.
2002: Atsushi Sugiyam; Yuko Ishida; Yoshioki Satoh; Shigeki Aoki; Masaaki Hori; Yasuki Akie; Yoshihiko Kobayashi; Keitaro Hashimoto
Electrophysiological, anatomical and histological remodeling of the heart to AV block enhances susceptibility to arrhythmogenic effects of QT-prolonging drugs.
Japanese journal of pharmacology 2002;88(3):341-50.
2002: Atsushi Sugiyama; Akira Takahara; Yoshioki Satoh; Masahiko Yoneyama; Yoshiki Saegusa; Keitaro Hashimoto
Cardiac effects of clinically available Kampo medicine assessed with canine isolated, blood-perfused heart preparations.
Japanese journal of pharmacology 2002;88(3):307-13.
2002: Atsushi Sugiyama; Bing-Mei Zhu; Akira Takahara; Yoshioki Satoh; Keitaro Hashimoto
Cardiac effects of salvia miltiorrhiza/dalbergia odorifera mixture, an intravenously applicable Chinese medicine widely used for patients with ischemic heart disease in China.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(2):182-4.
2002: Bing-Mei Zhu; Shigeki Miyamoto; Kazunori Kamiya; Sadayoshi Komori; Keitaro Hashimoto
Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat.
Japanese journal of pharmacology 2002;88(1):93-9.
2001: Keitaro Hashimoto
[Na+/H+ exchange inhibitors for ischemic diseases].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2001;118(6):363-70.
2001: Atsushi Sugiyama; Yoshioki Satoh; Hiroyuki Shiina; Akira Takahara; M Yoneyama; Keitaro Hashimoto
Cardiac electrophysiologic and hemodynamic effects of sildenafil, a PDE5 inhibitor, in anesthetized dogs.
Journal of cardiovascular pharmacology 2001;38(6):940-6.
2001: Atsushi Sugiyama; Yoshioki Satoh; Keitaro Hashimoto
Acute electropharmacological effects of intravenously administered amiodarone assessed in the in vivo canine model.
Japanese journal of pharmacology 2001;87(1):74-82.
2001: Atsushi Sugiyama; Yoshioki Satoh; Keitaro Hashimoto
Electropharmacologic effects of a new phosphodiesterase III inhibitor, toborinone (OPC-18790), assessed in an in vivo canine model.
Journal of cardiovascular pharmacology 2001;38(2):268-77.
2001: Atsushi Sugiyama; Yoshioki Satoh; Keitaro Hashimoto
In vivo canine model comparison of cardiohemodynamic and electrophysiological effects of a new antipsychotic drug aripiprazole (OPC-14597) to haloperidol.
Toxicology and applied pharmacology 2001;173(2):120-8.
2001: N Homma; G Tsujimoto; Keitaro Hashimoto
Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.
Japanese journal of pharmacology 2001;86(1):23-31.
2001: Shigeki Miyamoto; Bing-Mei Zhu; NN Aye; Keitaro Hashimoto
Slowing Na+ channel inactivation prolongs QT interval and aggravates adrenaline-induced arrhythmias.
Japanese journal of pharmacology 2001;86(1):114-9.
2000: K Chiba; Atsushi Sugiyama; Yoshioki Satoh; Hiroyuki Shiina; Keitaro Hashimoto
Proarrhythmic effects of fluoroquinolone antibacterial agents: in vivo effects as physiologic substrate for torsades.
Toxicology and applied pharmacology 2000;169(1):8-16.
2000: Yoshioki Satoh; Atsushi Sugiyama; K Chiba; K Tamura; Keitaro Hashimoto
QT-prolonging effects of sparfloxacin, a fluoroquinolone antibiotic, assessed in the in vivo canine model with monophasic action potential monitoring.
Journal of cardiovascular pharmacology 2000;36(4):510-5.
2000: Shigeki Miyamoto; B Zhu; T Teramatsu; NN Aye; Keitaro Hashimoto
QT-prolonging class I drug, disopyramide, does not aggravate but suppresses adrenaline-induced arrhythmias. Comparison with cibenzoline and pilsicainide.
European journal of pharmacology 2000;400(2-3):263-9.
2000: Atsushi Sugiyama; NN Aye; Yutaka Yatomi; Y Ozaki; Keitaro Hashimoto
Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system.
Japanese journal of pharmacology 2000;82(4):338-42.
2000: Keitaro Hashimoto
[Na+/H+ exchange inhibitors].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1140-4.
2000: Atsushi Sugiyama; Yutaka Yatomi; Y Ozaki; Keitaro Hashimoto
Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart.
Cardiovascular research 2000;46(1):119-25.
2000: M Saitoh; NN Aye; Sadayoshi Komori; T Nakazawa; Keitaro Hashimoto
Effects of HNS-32, a novel antiarrhythmic drug, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats.
Molecular and cellular biochemistry 2000;205(1-2):133-40.
2000: H Naito; Y Furukawa; Daisuke Chino; Chikaomi Yamada; Keitaro Hashimoto
Effects of zatebradine and propranolol on canine ischemia and reperfusion-induced arrhythmias.
European journal of pharmacology 2000;388(2):171-6.
2000: Yoshiki Saegusa; Atsushi Sugiyama; Keitaro Hashimoto
Utilization of spectral absorption for measurement of adenylate cyclase activity.
Journal of clinical laboratory analysis 2000;14(3):115-9.
2000: Atsushi Sugiyama; T Shirai; K Inoue; K G Lurie; Keitaro Hashimoto
Measurement of adenylate cyclase activity in the right ventricular endomyocardial biopsy samples from patients with chronic congestive heart failure.
Journal of clinical laboratory analysis 2000;14(2):48-52.
1999: Atsushi Sugiyama; K G Lurie; S M Efange; S Takehana; Keitaro Hashimoto
Direct cardiac effects of a novel vesamicol receptor ligand, m-iodobenzyl-trozamicol, assessed in the canine isolated, blood-perfused heart preparations.
Journal of cardiovascular pharmacology 1999;34(6):843-7.
1999: S Takehana; Atsushi Sugiyama; Keitaro Hashimoto
Cardiovascular effects of optical isomers of cibenzoline, assessed in the canine isolated, blood-perfused papillary muscle and sinoatrial node preparations.
Journal of cardiovascular pharmacology 1999;34(5):660-5.
1999: Y Xue; Chikaomi Yamada; Daisuke Chino; Keitaro Hashimoto
Effects of azimilide, a KV(r) and KV(s) blocker, on canine ventricular arrhythmia models.
European journal of pharmacology 1999;376(1-2):27-35.
1999: A Haruno; Atsushi Sugiyama; Keitaro Hashimoto
Chronotropic, inotropic, dromotropic and coronary vasodilator effects of bisaramil, a new class I antiarrhythmic drug, assessed using canine isolated, blood-perfused heart preparations.
Japanese journal of pharmacology 1999;80(3):267-70.
1999: Atsushi Sugiyama; S Takehana; Keitaro Hashimoto
Pharmacological evaluation of a new laser blood flowmeter for measuring coronary blood flow, assessed in the canine isolated, blood-perfused ventricular tissue preparation in comparison with an electromagnetic flowmeter.
Japanese journal of pharmacology 1999;80(3):263-6.
1999: Atsushi Sugiyama; Akira Takahara; Keitaro Hashimoto
Electrophysiologic, cardiohemodynamic and beta-blocking actions of a new ultra-short-acting beta-blocker, ONO-1101, assessed by the in vivo canine model in comparison with esmolol.
Journal of cardiovascular pharmacology 1999;34(1):70-7.
1999: Atsushi Sugiyama; Keitaro Hashimoto
Can the MAP technique be applied to detect delayed afterdepolarization? Electrophysiologic and pharmacologic evidence.
Journal of cardiovascular pharmacology 1999;34(1):46-52.
1999: NN Aye; Sadayoshi Komori; Keitaro Hashimoto
Effects and interaction, of cariporide and preconditioning on cardiac arrhythmias and infarction in rat in vivo.
British journal of pharmacology 1999;127(4):1048-55.
1999: Atsushi Sugiyama; S Takehana; R Kimura; Keitaro Hashimoto
Negative chronotropic and inotropic effects of class I antiarrhythmic drugs assessed in isolated canine blood-perfused sinoatrial node and papillary muscle preparations.
Heart and vessels 1999;14(2):96-103.
1999: N Sawada; Atsushi Sugiyama; K Kashiwagi; S Tsukahara; Keitaro Hashimoto
Measurement of adenylate cyclase activity in the minute bovine ciliary epithelial cells during the pharmacological stimulation of adrenergic and cholinergic receptors.
Journal of clinical laboratory analysis 1999;13(2):90-4.
1999: Atsushi Sugiyama; NN Aye; N Sawada; Keitaro Hashimoto
Cariporide, a highly selective Na+/H+ exchange inhibitor, suppresses the reperfusion-induced lethal arrhythmias and "overshoot" phenomenon of creatine phosphate in situ rat heart.
Journal of cardiovascular pharmacology 1999;33(1):116-21.
1999: Atsushi Sugiyama; Keitaro Hashimoto
Antiischemic effects of CP-060S, an inhibitor of pathologically modified sodium channels, assessed in the canine experimental model of angina pectoris.
Journal of cardiovascular pharmacology 1999;33(1):70-7.
1998: Y X Xue; J Arita; NN Aye; Keitaro Hashimoto
Effects of an antiarrhythmic drug A-2545 on canine ventricular arrhythmia models; comparison with mexiletine and flecainide.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(6):649-56.
1998: Atsushi Sugiyama; Keitaro Hashimoto
Effects of gastrointestinal prokinetic agents, TKS159 and cisapride, on the in situ canine heart assessed by cardiohemodynamic and electrophysiological monitoring.
Toxicology and applied pharmacology 1998;152(1):261-9.
1998: Y Xue; C Yamada; NN Aye; Keitaro Hashimoto
MS-551 and KCB-328, two class III drugs aggravated adrenaline-induced arrhythmias.
British journal of pharmacology 1998;124(8):1712-8.
1998: Y Xue; S Tanabe; Y Nabuchi; Keitaro Hashimoto
Antiarrhythmic effects of a novel class III drug, KCB-328, on canine ventricular arrhythmia models.
Journal of cardiovascular pharmacology 1998;32(2):239-47.
1998: K Eto; Keitaro Hashimoto; H Nakaya
Preferential inhibition of Ikr by MCI-154, a putative cardiotonic Ca2+ sensitizer, in guinea pig atrial cells.
Cardiovascular research 1998;38(3):685-94.
1998: A Hagihara; Atsushi Sugiyama; Keitaro Hashimoto
Effects of antiarrhythmic drugs on the monophasic action potential of the canine isolated, blood-perfused ventricular septum preparation.
Heart and vessels 1998;13(4):181-8.
1997: NN Aye; Y X Xue; Keitaro Hashimoto
Antiarrhythmic effects of cariporide, a novel Na+-H+ exchange inhibitor, on reperfusion ventricular arrhythmias in rat hearts.
European journal of pharmacology 1997;339(2-3):121-7.
1997: Y Xue; NN Aye; Keitaro Hashimoto
[Antiarrhythmic effects of DHA-As on ventricular arrhythmias in rat and dog hearts].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1997;110 Suppl 1():165P-170P.
1997: M Saitoh; Atsushi Sugiyama; A Hagihara; T Nakazawa; Keitaro Hashimoto
Cardiovascular and antiarrhythmic effects of the azulene-1-carboxamidine derivative N1,N1-dimethyl-N2-(2-pyridylmethyl)-5-isopropyl-3, 8-dimethylazulene-1-carboxamidine.
Arzneimittel-Forschung 1997;47(7):810-5.
1997: Atsushi Sugiyama; NN Aye; S Katahira; A Hagihara; Keitaro Hashimoto
Effects of magnesium sulfate on the canine cardiovascular system complicating astemizole overdose.
Journal of cardiovascular pharmacology 1997;29(6):795-800.
1997: Atsushi Sugiyama; NN Aye; S Katahira; M Saitoh; A Hagihara; Y Matsubara; Keitaro Hashimoto
Effects of nonsedating antihistamine, astemizole, on the in situ canine heart assessed by cardiohemodynamic and monophasic action potential monitoring.
Toxicology and applied pharmacology 1997;143(1):89-95.
1997: H Naito; Y Furukawa; Keitaro Hashimoto
Effects of a cardioselective M2 receptor antagonist, AF-DX 116, on ventricular arrhythmias in dogs.
Heart and vessels 1997;12(5):229-33.
1996: J Arita; Y X Xue; NN Aye; K Fukuyama; Y Wakui; K Niitsu; M Maruno; C Siying; Keitaro Hashimoto
Antiarrhythmic effects of an aconitine-like compound, TJN-505, on canine arrhythmia models.
European journal of pharmacology 1996;318(2-3):333-40.
1996: Y X Xue; NN Aye; Keitaro Hashimoto
Antiarrhythmic effects of HOE642, a novel Na(+)-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts.
European journal of pharmacology 1996;317(2-3):309-16.
1996: J Chen; S Komori; B Li; K Tamura; Keitaro Hashimoto
IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats.
British journal of pharmacology 1996;119(5):937-42.
1996: J Chen; Y Xue; K Eto; C Ni; Keitaro Hashimoto
Effects of dofetilide, a class III antiarrhythmic drug, on various ventricular arrhythmias in dogs.
Journal of cardiovascular pharmacology 1996;28(4):576-84.
1996: Atsushi Sugiyama; C Ni; J Arita; K Eto; Y X Xue; Keitaro Hashimoto
Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording.
Toxicology and applied pharmacology 1996;139(1):109-14.
1996: Y Furukawa; Y X Xue; S Chiba; Keitaro Hashimoto
Effects of zatebradine on ouabain-, two-stage coronary ligation- and epinephrine-induced ventricular tachyarrhythmias.
European journal of pharmacology 1996;300(3):203-10.
1996: K Eto; Y X Xue; Keitaro Hashimoto
Effects of MCI-154, a new cardiotonic Ca2+ sensitizer, on ventricular arrhythmias and membrane ionic currents.
European journal of pharmacology 1996;298(3):247-56.
1996: M Nakamura; Y Xue; K Eto; Keitaro Hashimoto
Antiarrhythmic effects of optical isomers of disopyramide on canine ventricular arrhythmias.
Journal of cardiovascular pharmacology 1996;27(3):368-75.
1996: Y X Xue; K Eto; Y Akie; Keitaro Hashimoto
Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models.
Japanese journal of pharmacology 1996;70(2):129-38.
1996: A Yamada; S Motomura; Keitaro Hashimoto
Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide.
Journal of cardiovascular pharmacology 1996;27(1):159-66.
1995: Takeo Awaji; Z J Wu; Keitaro Hashimoto
Acute antiarrhythmic effects of intravenously administered amiodarone on canine ventricular arrhythmia.
Journal of cardiovascular pharmacology 1995;26(6):869-78.
1995: A Haruno; Keitaro Hashimoto
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog.
Japanese journal of pharmacology 1995;68(1):95-102.
1995: Keitaro Hashimoto; A Haruno; Akira Hirasawa; Takeo Awaji; Y Xue; Z Wu
Effects of the new class III antiarrhythmic drug MS-551 and d-sotalol on canine coronary ligation-reperfusion ventricular arrhythmias.
Japanese journal of pharmacology 1995;68(1):1-9.
1994: Atsushi Sugiyama; S Motomura; Keitaro Hashimoto
Utilization of an isolated, blood-perfused canine papillary muscle preparation as a model to assess efficacy and adversity of class I antiarrhythmic drugs.
Japanese journal of pharmacology 1994;66(3):303-16.
1993: Akira Hirasawa; Takeo Awaji; M Hosono; A Haruno; Keitaro Hashimoto
Effects of a new forskolin derivative, NKH477, on canine ventricular arrhythmia models.
Journal of cardiovascular pharmacology 1993;22(6):847-51.
1993: Z Wu; Takeo Awaji; H Abe; S Motomura; Keitaro Hashimoto
Effects of OPC-18790, a new positive inotropic agent, on canine ventricular arrhythmias.
Japanese journal of pharmacology 1993;63(3):399-404.
1993: Takeo Awaji; Keitaro Hashimoto
Antiarrhythmic effects of combined application of class I antiarrhythmic drugs; addition of low-dose mexiletine-enhanced antiarrhythmic effects of disopyramide and aprindine in various-rate canine ventricular tachycardias.
Journal of cardiovascular pharmacology 1993;21(6):960-6.
1993: A Haruno; Keitaro Hashimoto
Antiarrhythmic effects of bisaramil in canine models of ventricular arrhythmia.
European journal of pharmacology 1993;233(1):1-6.
1993: W Zhenjiu; Takeo Awaji; Akira Hirasawa; S Motomura; Keitaro Hashimoto
Effects of a new class I antiarrhythmic drug bidisomide on canine ventricular arrhythmia models.
Molecular and cellular biochemistry 1993;119(1-2):159-69.
1993: T Matsuzaki; A Haruno; Keitaro Hashimoto
Effects of gallopamil, a Ca2+ channel blocker in models of ventricular arrhythmia in dogs.
European journal of pharmacology 1993;231(3):363-70.
1993: S Motomura; Z J Wu; Keitaro Hashimoto
Lacidipine, a new long-acting dihydropyridine calcium antagonist, has high vascular selectivity against all intracardiac variables.
Heart and vessels 1993;8(1):16-22.
1992: Akira Hirasawa; A Haruno; T Matsuzaki; Keitaro Hashimoto
Effects of a new antiarrhythmic drug, SD-3212, on canine ventricular arrhythmia models.
Japanese heart journal 1992;33(6):851-61.
1992: Z Wu; Takeo Awaji; S Motomura; Keitaro Hashimoto
[Effects of a new antiarrhythmic drug, KW-3407, on canine ventricular arrhythmia models].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1992;100(2):117-26.
1992: S Motomura; Keitaro Hashimoto
Beta 2-adrenoceptor-mediated positive dromotropic effects on atrioventricular node of dogs.
The American journal of physiology 1992;262(1 Pt 2):H123-9.
1991: Keitaro Hashimoto; A Haruno; T Matsuzaki; Atsushi Sugiyama; K Akiyama
Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: which electrophysiological characteristics of drugs are related to their effectiveness?
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1991;5 Suppl 4():805-17.
1991: Atsushi Sugiyama; S Motomura; Keitaro Hashimoto
Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.
Japanese journal of pharmacology 1991;56(1):1-12.
1991: Keitaro Hashimoto; Atsushi Sugiyama; A Haruno; T Matsuzaki; Akira Hirasawa
Effects of a new antiarrhythmic drug TYB-3823 on canine ventricular arrhythmia models.
Journal of cardiovascular pharmacology 1991;17(2):336-42.
1991: H Satoh; Keitaro Hashimoto
Comparative effects of a new calcium channel antagonist, mepirodipine, on rabbit spontaneously beating sino-atrial node cells.
European journal of pharmacology 1991;193(1):9-13.
1990: E Suzuki; G Tsujimoto; K Tamura; Keitaro Hashimoto
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.
Molecular pharmacology 1990;38(5):725-36.
1990: A Haruno; T Matsuzaki; Keitaro Hashimoto
Antiarrhythmic effects of optical isomers of cibenzoline on canine ventricular arrhythmias.
Journal of cardiovascular pharmacology 1990;16(3):376-82.
1990: K Akiyama; Keitaro Hashimoto
Effects of lidocaine, disopyramide and verapamil on the in vivo triggered ventricular arrhythmia in digitalized canine heart.
Japanese journal of pharmacology 1990;53(4):419-26.
1990: Atsushi Sugiyama; S Motomura; K Tamura; Keitaro Hashimoto
Comparison of cardiovascular effects of pirmenol with those of disopyramide in isolated canine heart preparations cross-circulated with a donor dog.
Japanese journal of pharmacology 1990;53(1):97-110.
1990: S Motomura; Keitaro Hashimoto
Reconsideration of vascular selectivity of dihydropyridine calcium antagonists: comparison of cardiovascular profile of mepirodipine, a novel dihydropyridine consisting of a single stereoisomer with (+)-(S)-(S) conformation, with those of nifedipine and nicardipine.
Japanese journal of pharmacology 1990;52(2):319-30.
1990: E Suzuki; G Tsujimoto; Keitaro Hashimoto
Different desensitization mechanisms of two alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta.
British journal of clinical pharmacology 1990;30 Suppl 1():121S-124S.
1989: Keitaro Hashimoto; K Watanabe; S Mochizuki; A Tomiyama
Effects of KT-362, a new Na and Ca influx and Ca release inhibitor, on canine ventricular arrhythmias.
Japanese journal of pharmacology 1989;51(4):475-82.
1989: Keitaro Hashimoto; T Matsuzaki; A Haruno
Antiarrhythmic plasma concentrations of NIK-244 on canine ventricular arrhythmias.
Journal of cardiovascular pharmacology 1989;14(6):892-8.
1989: H Satoh; M Ishii; Keitaro Hashimoto
An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.
British journal of pharmacology 1989;98(3):827-32.
1989: Atsushi Sugiyama; Keitaro Hashimoto
Chronotropic and inotropic effects of kampo extracts in the canine isolated, blood-perfused heart preparations.
Japanese journal of pharmacology 1989;51(2):239-46.
1989: Keitaro Hashimoto; K Watanabe; H Mitsuhashi
Antiarrhythmic effect of a new class 1 antiarrhythmic drug, AN-132, on ventricular arrhythmias in beagles.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1989;3(5):683-9.
1989: Atsushi Sugiyama; M Kobayashi; G Tsujimoto; S Motomura; Keitaro Hashimoto
The first demonstration of CGRP-immunoreactive fibers in canine hearts: coronary vasodilator, inotropic and chronotropic effects of CGRP in canine isolated, blood-perfused heart preparations.
Japanese journal of pharmacology 1989;50(4):421-7.
1989: G Tsujimoto; A Tsujimoto; E Suzuki; Keitaro Hashimoto
Glycogen phosphorylase activation by two different alpha 1-adrenergic receptor subtypes: methoxamine selectively stimulates a putative alpha 1-adrenergic receptor subtype (alpha 1a) that couples with Ca2+ influx.
Molecular pharmacology 1989;36(1):166-76.
1989: K Akiyama; Keitaro Hashimoto
Antiarrhythmic effects of the class 1c antiarrhythmic drug, flecainide, on canine ventricular arrhythmia models.
Japanese heart journal 1989;30(4):487-95.
1989: Keitaro Hashimoto; M Ishii; K Watanabe
Relationships between ventricular arrhythmias and plasma concentrations of ME3202 (CM7857) in dogs.
Journal of cardiovascular pharmacology 1989;14(1):121-6.
1989: S Motomura; Keitaro Hashimoto
Histamine H2-receptor mediated positive dromotropic effect in the canine atrioventricular node.
Japanese journal of pharmacology 1989;49(3):325-35.
1989: H Satoh; K Tsuchida; Keitaro Hashimoto
Electrophysiological actions of A23187 and X-537A in spontaneously beating and in voltage-clamped rabbit sino-atrial node preparations.
Naunyn-Schmiedeberg's archives of pharmacology 1989;339(3):320-6.
1989: Keitaro Hashimoto; K Akiyama; H Mitsuhashi
Antiarrhythmic effect of a new class 1 antiarrhythmic drug, nicainoprol, on canine ventricular arrhythmias.
Japanese journal of pharmacology 1989;49(2):245-54.
1989: Keitaro Hashimoto
[Effects of antiarrhythmic drugs on canine ventricular arrhythmia models].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1989;93(2):29-39.
1988: G Tsujimoto; A Tsujimoto; K Kato; Keitaro Hashimoto
In vivo desensitization of glycogenolysis to Ca2+-mobilizing hormones in rat liver cells.
The Journal of clinical investigation 1988;82(6):1922-33.
1988: Keitaro Hashimoto; K Watanabe; Atsushi Sugiyama
Antiarrhythmic plasma concentrations of pirmenol on canine ventricular arrhythmias.
Japanese journal of pharmacology 1988;48(2):273-82.
1988: S Motomura; M Ohta; K Ohyama; Keitaro Hashimoto
Release of atrial natriuretic peptide from the isolated, blood-perfused right atrium of the dog.
Japanese journal of pharmacology 1988;47(3):285-91.
1988: H Mitsuhashi; Keitaro Hashimoto
Antiarrhythmic profile of a new class 1 drug, AHR 10718, on canine atrial and ventricular arrhythmia models.
Japanese journal of pharmacology 1988;46(4):349-58.
1988: H Satoh; Keitaro Hashimoto
Effect of alpha 1-adrenoceptor stimulation with methoxamine and phenylephrine on spontaneously beating rabbit sino-atrial node cells.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(4):415-22.
1988: H Satoh; Keitaro Hashimoto
On electrophysiological responses to phorbol esters which stimulate protein kinase C in rabbit sino-atrial node cells.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(3):308-15.
1987: S Motomura; Keitaro Hashimoto; K Hashimoto
Effects of Bay k 8644 on the coronary vascular selectivity of the dihydropyridine Ca antagonists in the canine isolated, blood-perfused papillary muscle preparation.
Journal of cardiovascular pharmacology 1987;10(6):627-35.
1987: G Tsujimoto; Keitaro Hashimoto
Effects of triiodo-L-thyronine (T3)-induced hyperthyroidism on the cardiovascular alpha-adrenoceptor system in young and older rats.
Japanese journal of pharmacology 1987;44(4):437-45.
1987: H Mitsuhashi; K Akiyama; Keitaro Hashimoto; Y Sawa; Y Hatori
Antiarrhythmic effects of a new drug, E-0747, on canine ventricular arrhythmia models.
Japanese journal of pharmacology 1987;44(2):155-62.
1987: H Satoh; M Ishii; Keitaro Hashimoto
Effect of cibenzoline, a class I antiarrhythmic drug, on action potential in canine ventricular muscle.
Japanese journal of pharmacology 1987;44(2):113-9.