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Makoto Hashimoto

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Paula Desplats; Masayo Fujita; Makoto Hashimoto; Kori Kosberg; Michael Mante; Pruthul Patel; Christina Patrick; Edward Rockenstein; Eliezer Masliah
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
Leslie Crews; Igor Tsigelny; Makoto Hashimoto; Eliezer Masliah
Role of synucleins in Alzheimer's disease.
Kohichi Kawahara; Makoto Hashimoto; Pazit Bar-On; Gilbert J Ho; Leslie Crews; Hideya Mizuno; Edward Rockenstein; Syed Z Imam; Eliezer Masliah
alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.

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All Publications

2012: Paula Desplats; Masayo Fujita; Makoto Hashimoto; Kori Kosberg; Michael Mante; Pruthul Patel; Christina Patrick; Edward Rockenstein; Eliezer Masliah
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
Molecular neurodegeneration 2012;7():49.
2009: Leslie Crews; Igor Tsigelny; Makoto Hashimoto; Eliezer Masliah
Role of synucleins in Alzheimer's disease.
Neurotoxicity research 2009;16(3):306-17.
2008: Kohichi Kawahara; Makoto Hashimoto; Pazit Bar-On; Gilbert J Ho; Leslie Crews; Hideya Mizuno; Edward Rockenstein; Syed Z Imam; Eliezer Masliah
alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.
The Journal of biological chemistry 2008;283(11):6979-87.
2007: Igor Tsigelny; Pazit Bar-On; Yuriy Sharikov; Leslie Crews; Makoto Hashimoto; Mark A Miller; Steven H Keller; Oleksandr Platoshyn; Jason X-J Yuan; Eliezer Masliah
Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein.
The FEBS journal 2007;274(7):1862-77.
2006: Pazit Bar-On; Edward Rockenstein; Anthony Adame; Gilbert Ho; Makoto Hashimoto; Eliezer Masliah
Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy.
Journal of neurochemistry 2006;98(4):1032-45.
2005: Clifford W Shults; Edward Rockenstein; Leslie Crews; Anthony Adame; Michael Mante; Gabriel Larrea; Makoto Hashimoto; David Song; Takeshi Iwatsubo; Kyoko Tsuboi; Eliezer Masliah
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10689-99.
2005: Edward Rockenstein; Michael Mante; Michael Alford; Anthony Adame; Leslie Crews; Makoto Hashimoto; Luke Esposito; Lennart Mucke; Eliezer Masliah
High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.
The Journal of biological chemistry 2005;280(38):32957-67.
2005: Eliezer Masliah; Edward Rockenstein; Anthony Adame; Michael Alford; Leslie Crews; Makoto Hashimoto; Peter Seubert; Michael Lee; Jason Goldstein; Tamie J Chilcote; Dora Games; Dale Schenk
Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.
Neuron 2005;46(6):857-68.
2005: Kyoko Tsuboi; John J Grzesiak; Michael Bouvet; Makoto Hashimoto; Eliezer Masliah; Clifford W Shults
Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death.
Molecular and cellular neurosciences 2005;29(2):259-68.
2005: Gilbert J Ho; Makoto Hashimoto; Anthony Adame; Matthew Izu; Michael Alford; Leon J Thal; Lawrence A Hansen; Eliezer Masliah
Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role.
Neurobiology of aging 2005;26(5):625-35.
2005: Dianne Langford; Rosemary Hurford; Makoto Hashimoto; Murat Digicaylioglu; Eliezer Masliah
Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.
BMC neuroscience 2005;6():8.
2004: Makoto Hashimoto; Edward Rockenstein; Michael Mante; Leslie Crews; Pazit Bar-On; Fred H Gage; Robert Marr; Eliezer Masliah
An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model.
Gene therapy 2004;11(23):1713-23.
2004: Makoto Hashimoto; Pazit Bar-On; Gilbert Ho; Takato Takenouchi; Edward Rockenstein; Leslie Crews; Eliezer Masliah
Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease.
The Journal of biological chemistry 2004;279(22):23622-9.
2004: Makoto Hashimoto; Kohichi Kawahara; Pazit Bar-On; Edward Rockenstein; Leslie Crews; Eliezer Masliah
The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease.
Journal of molecular neuroscience : MN 2004;24(3):343-52.
2003: Makoto Hashimoto; Eliezer Masliah
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.
Neurochemical research 2003;28(11):1743-56.
2003: Makoto Hashimoto; Edward Rockenstein; Eliezer Masliah
Transgenic models of alpha-synuclein pathology: past, present, and future.
Annals of the New York Academy of Sciences 2003;991():171-88.
2003: Makoto Hashimoto; Takato Takenouchi; Edward Rockenstein; Eliezer Masliah
Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.
Journal of neurochemistry 2003;85(6):1468-79.
2003: Makoto Hashimoto; Edward Rockenstein; Leslie Crews; Eliezer Masliah
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.
Neuromolecular medicine 2003;4(1-2):21-36.
2002: Makoto Hashimoto; Yutaka Sagara; Dianne Langford; Ian Everall; Margaret Mallory; Analisa Everson; Murat Digicaylioglu; Eliezer Masliah
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
The Journal of biological chemistry 2002;277(36):32985-91.
2002: Edward Rockenstein; Margaret Mallory; Makoto Hashimoto; David Song; Clifford W Shults; Ingrid Lang; Eliezer Masliah
Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters.
Journal of neuroscience research 2002;68(5):568-78.
2002: Makoto Hashimoto; Leigh J Hsu; Edward Rockenstein; Takato Takenouchi; Margaret Mallory; Eliezer Masliah
alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells.
The Journal of biological chemistry 2002;277(13):11465-72.
2001: Makoto Hashimoto; Edward Rockenstein; Michael Mante; Margaret Mallory; Eliezer Masliah
beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor.
Neuron 2001;32(2):213-23.
2001: Eliezer Masliah; Edward Rockenstein; isaac veinbergs; Yutaka Sagara; Margaret Mallory; Makoto Hashimoto; Lennart Mucke
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12245-50.
2001: L Hsu; Edward Rockenstein; Margaret Mallory; Makoto Hashimoto; Eliezer Masliah
Altered expression of glutamate transporters under hypoxic conditions in vitro.
Journal of neuroscience research 2001;64(2):193-202.
2001: Takato Takenouchi; Makoto Hashimoto; Leigh J Hsu; B Mackowski; Edward Rockenstein; Margaret Mallory; Eliezer Masliah
Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein.
Molecular and cellular neurosciences 2001;17(1):141-50.
2000: Leigh J Hsu; Yutaka Sagara; A Arroyo; Edward Rockenstein; Abbyann Sisk; Margaret Mallory; J Wong; Takato Takenouchi; Makoto Hashimoto; Eliezer Masliah
alpha-synuclein promotes mitochondrial deficit and oxidative stress.
The American journal of pathology 2000;157(2):401-10.
2000: A Takeda; Makoto Hashimoto; Margaret Mallory; M Sundsumo; Lawrence A Hansen; Eliezer Masliah
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Acta neuropathologica 2000;99(3):296-304.
2000: Eliezer Masliah; Edward Rockenstein; isaac veinbergs; Margaret Mallory; Makoto Hashimoto; A Takeda; Yutaka Sagara; Abbyann Sisk; Lennart Mucke
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.
Science (New York, N.Y.) 2000;287(5456):1265-9.
1999: Makoto Hashimoto; A Takeda; Leigh J Hsu; Takato Takenouchi; Eliezer Masliah
Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease.
The Journal of biological chemistry 1999;274(41):28849-52.
1999: Makoto Hashimoto; Eliezer Masliah
Alpha-synuclein in Lewy body disease and Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 1999;9(4):707-20.
1999: Makoto Hashimoto; Leigh J Hsu; Y Xia; A Takeda; Abbyann Sisk; M Sundsmo; Eliezer Masliah
Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro.
Neuroreport 1999;10(4):717-21.
1998: A Takeda; Makoto Hashimoto; Margaret Mallory; M Sundsumo; Lawrence A Hansen; Abbyann Sisk; Eliezer Masliah
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.
Laboratory investigation; a journal of technical methods and pathology 1998;78(9):1169-77.
1998: Makoto Hashimoto; Leigh J Hsu; Abbyann Sisk; Y Xia; A Takeda; M Sundsmo; Eliezer Masliah
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease.
Brain research 1998;799(2):301-6.
1998: Leigh J Hsu; Margaret Mallory; Y Xia; isaac veinbergs; Makoto Hashimoto; M Yoshimoto; Leon J Thal; T Saitoh; Eliezer Masliah
Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development.
Journal of neurochemistry 1998;71(1):338-44.
1998: Makoto Hashimoto; Satoshi Inoue; S Ogawa; C Conrad; M Muramatsu; Deborah A Shackelford; Eliezer Masliah
Rapid fragmentation of vimentin in human skin fibroblasts exposed to tamoxifen: a possible involvement of caspase-3.
Biochemical and biophysical research communications 1998;247(2):401-6.
1997: Makoto Hashimoto; Satoshi Inoue; M Muramatsu; Eliezer Masliah
Estrogens stimulate tamoxifen-induced neuronal cell apoptosis in vitro: a possible nongenomic action.
Biochemical and biophysical research communications 1997;240(2):464-70.
1997: Makoto Hashimoto; M Yoshimoto; Abbyann Sisk; Leigh J Hsu; M Sundsmo; A Kittel; T Saitoh; A Miller; Eliezer Masliah
NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation.
Biochemical and biophysical research communications 1997;237(3):611-6.