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Yuichi Hashimoto

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TOP 3
Masaharu Nakamura; Makoto Makishima; Yuichi Hashimoto
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.
Kenji Ohgane; Fumika Karaki; Kosuke Dodo; Yuichi Hashimoto
Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site.
Yusuke Mita; Tomomi Noguchi-Yachide; Kosuke Dodo; Yuichi Hashimoto; Minoru Ishikawa
Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.

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All Publications

2013: Masaharu Nakamura; Makoto Makishima; Yuichi Hashimoto
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.
Bioorganic & medicinal chemistry 2013;21(7):1643-51.
2013: Kenji Ohgane; Fumika Karaki; Kosuke Dodo; Yuichi Hashimoto
Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site.
Chemistry & biology 2013;20(3):391-402.
2013: Yusuke Mita; Tomomi Noguchi-Yachide; Kosuke Dodo; Yuichi Hashimoto; Minoru Ishikawa
Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.
Bioorganic & medicinal chemistry 2013;21(4):993-1005.
2013: Yusuke Mita; Tomomi Noguchi-Yachide; Minoru Ishikawa; Yuichi Hashimoto
Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.
Bioorganic & medicinal chemistry 2013;21(3):608-17.
2013: Masaharu Nakamura; Masaaki Toyama; Masanori Baba; Yotaro Matsumoto; Yuichi Hashimoto
Organosilicon compounds as adult T-cell leukemia cell proliferation inhibitors.
Chemical & pharmaceutical bulletin 2013;61(2):237-41.
2012: Hiromi Sawada; Daichi Morita; Miki Okazaki; Yuichi Hashimoto; Teruo Kuroda; Kenji Matsuno; Hiroyuki Miyachi
Riccardin C derivatives as anti-MRSA agents: structure-activity relationship of a series of hydroxylated bis(bibenzyl)s.
Bioorganic & medicinal chemistry letters 2012;22(24):7444-7.
2012: Shinpei Murasawa; Tomomi Noguchi-Yachide; Shinichi Sato; Mikiko Sodeoka; Tsutomu Yokomatsu; Kosuke Dodo; Yuichi Hashimoto; Katsuya Iuchi; Hiroshi Aoyama
Small-molecular inhibitors of Ca²⁺-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene.
Bioorganic & medicinal chemistry 2012;20(21):6384-93.
2012: Masao Ohashi; Izumi Nakagome; Hiromi Nobusada; Yuichi Hashimoto; Shuichi Hirono; Jun-ichi Kasuga; Makoto Makishima; Kenji Matsuno; Hiroyuki Miyachi
Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry-activity relationship.
Bioorganic & medicinal chemistry 2012;20(21):6375-83.
2012: Atsushi Aoyama; Hiroshi Aoyama; Kaori Endo-Umeda; Minoru Ishikawa; Kenji Kishida; Makoto Makishima; Hiroyuki Miyachi; Tomomi Noguchi-Yachide; Kenji Ohgane; Yuichi Hashimoto
Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.
Journal of medicinal chemistry 2012;55(17):7360-77.
2012: Yukihiro Itoh; Risa Kitaguchi; Mikihiko Naito; Keiichiro Okuhira; Minoru Ishikawa; Yuichi Hashimoto
Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist.
Bioorganic & medicinal chemistry letters 2012;22(13):4453-7.
2012: Takashi Misawa; Yuichi Sugiyama; Hisamitsu Hayashi; Makoto Makishima; Yuichi Hashimoto
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.
Bioorganic & medicinal chemistry letters 2012;22(12):3962-6.
2012: Takashi Misawa; Yuichi Sugiyama; Hisamitsu Hayashi; Yuichi Hashimoto
Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2.
Bioorganic & medicinal chemistry 2012;20(9):2940-9.
2011: Yukihiro Itoh; Risa Kitaguchi; Mikihiko Naito; Minoru Ishikawa; Yuichi Hashimoto
Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.
Bioorganic & medicinal chemistry 2011;19(22):6768-78.
2011: Yukihiro Itoh; Minoru Ishikawa; Risa Kitaguchi; Shinichi Sato; Mikihiko Naito; Yuichi Hashimoto
Development of target protein-selective degradation inducer for protein knockdown.
Bioorganic & medicinal chemistry 2011;19(10):3229-41.
2011: Kazunori Motoshima; Minoru Ishikawa; Yuichi Hashimoto; Kazuyuki Sugita
Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity.
Bioorganic & medicinal chemistry 2011;19(10):3156-72.
2011: Kazunori Motoshima; Kazuyuki Sugita; Yuichi Hashimoto; Minoru Ishikawa
Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists.
Bioorganic & medicinal chemistry letters 2011;21(10):3041-5.
2011: Hiroshi Aoyama; Kazuyuki Sugita; Masahiko Nakamura; Atsushi Aoyama; Mohammed T A Salim; Mika Okamoto; Masanori Baba; Yuichi Hashimoto
Fused heterocyclic amido compounds as anti-hepatitis C virus agents.
Bioorganic & medicinal chemistry 2011;19(8):2675-87.
2011: Minoru Ishikawa; Yuichi Hashimoto
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.
Journal of medicinal chemistry 2011;54(6):1539-54.
2011: Kenji Ohgane; Kosuke Dodo; Yuichi Hashimoto
[Structural development study of a novel pharmacological chaperone for folding-defective rhodopsin mutants responsible for retinitis pigmentosa].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2011;131(3):325-34.
2011: Kazunori Motoshima; Yuichi Hashimoto; Minoru Ishikawa; Kazuyuki Sugita
Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide.
Chemical & pharmaceutical bulletin 2011;59(7):880-4.
2010: Keisuke Maruyama; Tomomi Noguchi-Yachide; Kazuyuki Sugita; Yuichi Hashimoto; Minoru Ishikawa
Novel selective anti-androgens with a diphenylpentane skeleton.
Bioorganic & medicinal chemistry letters 2010;20(22):6661-6.
2010: Jun-ichi Kasuga; Minoru Ishikawa; Mitsuhiro Yonehara; Makoto Makishima; Yuichi Hashimoto; Hiroyuki Miyachi
Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry.
Bioorganic & medicinal chemistry 2010;18(20):7164-73.
2010: Kenji Ohgane; Kosuke Dodo; Yuichi Hashimoto
Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for retinitis pigmentosa.
Bioorganic & medicinal chemistry 2010;18(19):7022-8.
2010: Masashi Tetsuhashi; Minoru Ishikawa; Mariko Hashimoto; Yuichi Hashimoto; Hiroshi Aoyama
Development of tryptase inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry 2010;18(14):5323-38.
2010: Masahiko Nakamura; Atsushi Aoyama; Mohammed T A Salim; Mika Okamoto; Masanori Baba; Hiroyuki Miyachi; Yuichi Hashimoto; Hiroshi Aoyama
Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton.
Bioorganic & medicinal chemistry 2010;18(7):2402-11.
2010: Yusuke Mita; Kosuke Dodo; Tomomi Noguchi-Yachide; Hiroyuki Miyachi; Makoto Makishima; Yuichi Hashimoto; Minoru Ishikawa
LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.
Bioorganic & medicinal chemistry letters 2010;20(5):1712-7.
2010: Yuji Fujita; Mitsuhiro Yonehara; Masashi Tetsuhashi; Tomomi Noguchi-Yachide; Yuichi Hashimoto; Minoru Ishikawa
beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity.
Bioorganic & medicinal chemistry 2010;18(3):1194-203.
2010: Tomomi Noguchi-Yachide; Kosuke Dodo; Hiroshi Aoyama; Haruka Fujimoto; Masatoshi Hori; Yuichi Hashimoto; Hisayoshi Kobayashi
Identification of binding proteins of fusarielin A as actin and tubulin.
Chemical & pharmaceutical bulletin 2010;58(1):129-34.
2009: Jun-ichi Kasuga; Seiichi Ishida; Daisuke Yamasaki; Makoto Makishima; Takefumi Doi; Yuichi Hashimoto; Hiroyuki Miyachi
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.
Bioorganic & medicinal chemistry letters 2009;19(23):6595-9.
2009: Kazunori Motoshima; Minoru Ishikawa; Kazuyuki Sugita; Yuichi Hashimoto
Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.
Biological & pharmaceutical bulletin 2009;32(9):1618-20.
2009: Shinnosuke Hosoda; Daisuke Matsuda; Hiroshi Tomoda; Mariko Hashimoto; Hiroshi Aoyama; Yuichi Hashimoto
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4228-31.
2009: Kazunori Motoshima; Tomomi Noguchi-Yachide; Kazuyuki Sugita; Yuichi Hashimoto; Minoru Ishikawa
Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.
Bioorganic & medicinal chemistry 2009;17(14):5001-14.
2009: Masahiko Nakamura; Takayuki Hamasaki; Maiko Tokitou; Masanori Baba; Yuichi Hashimoto; Hiroshi Aoyama
Discovery of tetrahydrotetramethylnaphthalene analogs as adult T-cell leukemia cell-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis.
Bioorganic & medicinal chemistry 2009;17(13):4740-6.
2009: Ken-ichi Wakabayashi; Masashi Okamura; Shuichi Tsutsumi; Naoko S Nishikawa; Toshiya Tanaka; Iori Sakakibara; Jun-ichi Kitakami; Sigeo Ihara; Yuichi Hashimoto; Takao Hamakubo; Tatsuhiko Kodama; Hiroyuki Aburatani; Juro Sakai
The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.
Molecular and cellular biology 2009;29(13):3544-55.
2009: Shinnosuke Hosoda; Hiroshi Aoyama; Yukinori Goto; Mohammed T A Salim; Mika Okamoto; Mariko Hashimoto; Masanori Baba; Yuichi Hashimoto
Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.
Bioorganic & medicinal chemistry letters 2009;19(12):3157-61.
2009: Jun-ichi Kasuga; Takuji Oyama; Izumi Nakagome; Atsushi Aoyama; Kumiko Sako; Makoto Makishima; Shuichi Hirono; Kosuke Morikawa; Yuichi Hashimoto; Hiroyuki Miyachi
[Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(6):709-18.
2009: Shinnosuke Hosoda; Daisuke Matsuda; Hiroshi Tomoda; Yuichi Hashimoto
Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.
Mini reviews in medicinal chemistry 2009;9(5):572-80.
2009: Tomomi Noguchi-Yachide; Masashi Tetsuhashi; Hiroshi Aoyama; Yuichi Hashimoto
Enhancement of chemically-induced HL-60 cell differentiation by 3,3'-diindolylmethane derivatives.
Chemical & pharmaceutical bulletin 2009;57(5):536-40.
2009: Kosuke Dodo; Taro Minato; Yuichi Hashimoto
Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate.
Chemical & pharmaceutical bulletin 2009;57(2):190-4.
2008: Jun-ichi Kasuga; Takuji Oyama; Izumi Nakagome; Makoto Makishima; Shuichi Hirono; Kosuke Morikawa; Yuichi Hashimoto; Hiroyuki Miyachi
Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists.
ChemMedChem 2008;3(11):1662-6.
2008: Takashi Misawa; Hiroshi Aoyama; Taniyuki Furuyama; Kosuke Dodo; Morihiko Sagawa; Hiroyuki Miyachi; Masahiro Kizaki; Yuichi Hashimoto
Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis.
Chemical & pharmaceutical bulletin 2008;56(10):1490-5.
2008: Yoko Araya; Jun-ichi Kasuga; Kenji Toyota; Yuko Hirakawa; Takuji Oyama; Makoto Makishima; Kosuke Morikawa; Yuichi Hashimoto; Hiroyuki Miyachi
Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands.
Chemical & pharmaceutical bulletin 2008;56(9):1357-9.
2008: Kosuke Dodo; Taro Minato; Tomomi Noguchi-Yachide; Masami Suganuma; Yuichi Hashimoto
Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.
Bioorganic & medicinal chemistry 2008;16(17):7975-82.
2008: Jun-ichi Kasuga; Takuji Oyama; Yuko Hirakawa; Makoto Makishima; Kosuke Morikawa; Yuichi Hashimoto; Hiroyuki Miyachi
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.
Bioorganic & medicinal chemistry letters 2008;18(16):4525-8.
2008: Aya Nakagawa; Shigeyuki Uno; Makoto Makishima; Hiroyuki Miyachi; Yuichi Hashimoto
Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton.
Bioorganic & medicinal chemistry 2008;16(14):7046-54.
2008: Ken-ichi Wakabayashi; Keisuke Imai; Hiroyuki Miyachi; Yuichi Hashimoto; Aya Tanatani
4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.
Bioorganic & medicinal chemistry 2008;16(14):6799-812.
2008: Shinichi Sato; Hiroshi Aoyama; Hiroyuki Miyachi; Mikihiko Naito; Yuichi Hashimoto
Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs.
Bioorganic & medicinal chemistry letters 2008;18(11):3354-8.
2008: Hisayoshi Kobayashi; Naoko Morisaki; Hiroyuki Miyachi; Yuichi Hashimoto
Coordination of divalent metal cation to amide group to form adduct ion in FAB mass spectrometry: implication of Zn2+ in enzymatic hydrolysis of amide bond.
Chemical & pharmaceutical bulletin 2008;56(5):672-6.
2008: Kosuke Dodo; Atsushi Aoyama; Tomomi Noguchi-Yachide; Makoto Makishima; Hiroyuki Miyachi; Yuichi Hashimoto
Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Bioorganic & medicinal chemistry 2008;16(8):4272-85.
2008: Shinichi Sato; Masashi Tetsuhashi; Keiko Sekine; Hiroyuki Miyachi; Mikihiko Naito; Yuichi Hashimoto; Hiroshi Aoyama
Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.
Bioorganic & medicinal chemistry 2008;16(8):4685-98.
2008: Kumiko Sako; Hiroshi Aoyama; Shinichi Sato; Yuichi Hashimoto; Masanori Baba
Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
Bioorganic & medicinal chemistry 2008;16(7):3780-90.
2008: Haruka Fujimoto; Hiroshi Aoyama; Tomomi Noguchi-Yachide; Yuichi Hashimoto; Hisayoshi Kobayashi
Fusarielin A as an anti-angiogenic and anti-proliferative agent: basic biological characterization.
Chemical & pharmaceutical bulletin 2008;56(3):298-304.
2008: Jun-ichi Kasuga; Daisuke Yamasaki; Kiyoshi Ogura; Motomu Shimizu; Mayumi Sato; Makoto Makishima; Takefumi Doi; Yuichi Hashimoto; Hiroyuki Miyachi
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.
Bioorganic & medicinal chemistry letters 2008;18(3):1110-5.
2008: Hiroyuki Miyachi; Yuichi Hashimoto
Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template.
PPAR research 2008;2008():689859.
2007: Tomomi Noguchi-Yachide; Hiroyuki Miyachi; Hiroshi Aoyama; Atsushi Aoyama; Makoto Makishima; Yuichi Hashimoto
Structural development of liver X receptor (LXR) antagonists derived from thalidomide-related glucosidase inhibitors.
Chemical & pharmaceutical bulletin 2007;55(12):1750-4.
2007: Shinnosuke Hosoda; Yuichi Hashimoto
3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.
Bioorganic & medicinal chemistry letters 2007;17(19):5414-8.
2007: Shoukou Lee; Chihiro Shinji; Kiyoshi Ogura; Motomu Shimizu; Satoko Maeda; Mayumi Sato; Minoru Yoshida; Yuichi Hashimoto; Hiroyuki Miyachi
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(17):4895-900.
2007: Jun-ichi Kasuga; Izumi Nakagome; Atsushi Aoyama; Kumiko Sako; Michiyasu Ishizawa; Michitaka Ogura; Makoto Makishima; Shuichi Hirono; Yuichi Hashimoto; Hiroyuki Miyachi
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Bioorganic & medicinal chemistry 2007;15(15):5177-90.
2007: Tomomi Noguchi-Yachide; Atsushi Aoyama; Makoto Makishima; Hiroyuki Miyachi; Yuichi Hashimoto
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(14):3957-61.
2007: Hiroshi Aoyama; Tomomi Noguchi; Takashi Misawa; Takanori Nakamura; Hiroyuki Miyachi; Yuichi Hashimoto; Hisayoshi Kobayashi
Development of tubulin-polymerization inhibitors based on the thalidomide skeleton.
Chemical & pharmaceutical bulletin 2007;55(6):944-9.
2007: Takanori Nakamura; Tomomi Noguchi; Hiroyuki Miyachi; Yuichi Hashimoto
Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.
Chemical & pharmaceutical bulletin 2007;55(4):651-4.
2007: Masahiko Kainuma; Makoto Makishima; Yuichi Hashimoto; Hiroyuki Miyachi
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
Bioorganic & medicinal chemistry 2007;15(7):2587-600.
2007: Masanobu Uchiyama; Yotaro Matsumoto; Shinya Usui; Yuichi Hashimoto; Keiji Morokuma
Origin of chemoselectivity of TMP zincate bases and differences between TMP zincate and alkyl lithium reagents: a DFT study on model systems.
Angewandte Chemie (International ed. in English) 2007;46(6):926-9.
2006: Jun-ichi Kasuga; Daisuke Yamasaki; Yoko Araya; Aya Nakagawa; Makoto Makishima; Takefumi Doi; Yuichi Hashimoto; Hiroyuki Miyachi
Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome.
Bioorganic & medicinal chemistry 2006;14(24):8405-14.
2006: Takanori Nakamura; Tomomi Noguchi; Hisayoshi Kobayashi; Hiroyuki Miyachi; Yuichi Hashimoto
Mono- and dihydroxylated metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.
Chemical & pharmaceutical bulletin 2006;54(12):1709-14.
2006: Chihiro Shinji; Satoko Maeda; Keisuke Imai; Minoru Yoshida; Yuichi Hashimoto; Hiroyuki Miyachi
Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors.
Bioorganic & medicinal chemistry 2006;14(22):7625-51.
2006: Tomonori Yanagawa; Tomomi Noguchi; Hiroyuki Miyachi; Hisayoshi Kobayashi; Yuichi Hashimoto
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
Bioorganic & medicinal chemistry letters 2006;16(18):4748-51.
2006: Shinnosuke Hosoda; Aya Tanatani; Ken-Ichi Wakabayashi; Makoto Makishima; Keisuke Imai; Hiroyuki Miyachi; Kazuo Nagasawa; Yuichi Hashimoto
Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation.
Bioorganic & medicinal chemistry 2006;14(16):5489-502.
2006: Masahiko Kainuma; Jun-ichi Kasuga; Shinnosuke Hosoda; Ken-ichi Wakabayashi; Aya Tanatani; Kazuo Nagasawa; Hiroyuki Miyachi; Makoto Makishima; Yuichi Hashimoto
Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
Bioorganic & medicinal chemistry letters 2006;16(12):3213-8.
2006: Haruka Fujimoto; Tomomi Noguchi; Hisayoshi Kobayashi; Hiroyuki Miyachi; Yuichi Hashimoto
Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.
Chemical & pharmaceutical bulletin 2006;54(6):855-60.
2006: Hiroko Sano; Tomomi Noguchi; Atsushi Miyajima; Yuichi Hashimoto; Hiroyuki Miyachi
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):3068-72.
2006: Yusuke Nakano; Yuko Kato; Keisuke Imai; Eiji Ochiai; Jun-Ichi Namekawa; Seiichi Ishizuka; Kazuya Takenouchi; Aya Tanatani; Yuichi Hashimoto; Kazuo Nagasawa
Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.
Journal of medicinal chemistry 2006;49(8):2398-406.
2006: Jun-ichi Kasuga; Yuichi Hashimoto; Hiroyuki Miyachi
Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: dual agonists for human peroxisome proliferator-activated receptor alpha and delta.
Bioorganic & medicinal chemistry letters 2006;16(4):771-4.
2006: Jun-ichi Kasuga; Makoto Makishima; Yuichi Hashimoto; Hiroyuki Miyachi
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.
Bioorganic & medicinal chemistry letters 2006;16(3):554-8.
2005: Tomomi Noguchi; Haruka Fujimoto; Hiroko Sano; Atsushi Miyajima; Hiroyuki Miyachi; Yuichi Hashimoto
Angiogenesis inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(24):5509-13.
2005: Jun Shimokawa; Takanori Ishiwata; Koji Shirai; Hiroyuki Koshino; Aya Tanatani; Tadashi Nakata; Yuichi Hashimoto; Kazuo Nagasawa
Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and identification of their target protein.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(23):6878-88.
2005: Chihiro Shinji; Takanori Nakamura; Satoko Maeda; Minoru Yoshida; Yuichi Hashimoto; Hiroyuki Miyachi
Design and synthesis of phthalimide-type histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(20):4427-31.
2005: Shinnosuke Hosoda; Aya Tanatani; Ken-ichi Wakabayashi; Yusuke Nakano; Hiroyuki Miyachi; Kazuo Nagasawa; Yuichi Hashimoto
Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities.
Bioorganic & medicinal chemistry letters 2005;15(19):4327-31.
2005: Yuichi Hashimoto; Hiroyuki Miyachi
Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.
Bioorganic & medicinal chemistry 2005;13(17):5080-93.
2005: Tomomi Noguchi; Hiroyuki Miyachi; Ryohei Katayama; Mikihiko Naito; Yuichi Hashimoto
Cell differentiation inducers derived from thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(13):3212-5.
2005: Hiroko Sano; Tomomi Noguchi; Aya Tanatani; Yuichi Hashimoto; Hiroyuki Miyachi
Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry 2005;13(9):3079-91.
2005: Ken-ichi Wakabayashi; Hiroyuki Miyachi; Yuichi Hashimoto; Aya Tanatani
Novel non-steroidal/non-anilide type androgen antagonists: discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands.
Bioorganic & medicinal chemistry 2005;13(8):2837-46.
2005: Tomomi Noguchi; Chihiro Shinji; Hisayoshi Kobayashi; Makoto Makishima; Hiroyuki Miyachi; Yuichi Hashimoto
Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.
Biological & pharmaceutical bulletin 2005;28(3):563-4.
2005: Shunsuke Inatsuki; Tomomi Noguchi; Hiroyuki Miyachi; Sawako Oda; Toyotaka Iguchi; Masahiro Kizaki; Yuichi Hashimoto; Hisayoshi Kobayashi
Tubulin-polymerization inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(2):321-5.
2004: Tomomi Noguchi; Hiroko Sano; Rumiko Shimazawa; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry letters 2004;14(16):4141-5.
2004: Hiroko Sano; Tomomi Noguchi; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto
N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: substituent effects on subtype selectivity.
Chemical & pharmaceutical bulletin 2004;52(8):1021-2.
2004: Yoshiyasu Baba; Satoshi Mayumi; Go Hirai; Hidekazu Kawasaki; Yosuke Ogoshi; Takeshi Yanagisawa; Yuichi Hashimoto; Mikiko Sodeoka
Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.
Bioorganic & medicinal chemistry letters 2004;14(11):2969-72.
2004: Yoshiyasu Baba; Yosuke Ogoshi; Go Hirai; Takeshi Yanagisawa; Kumiko Nagamatsu; Satoshi Mayumi; Yuichi Hashimoto; Mikiko Sodeoka
Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.
Bioorganic & medicinal chemistry letters 2004;14(11):2963-7.
2004: Yuko Kato; Yusuke Nakano; Hiroko Sano; Aya Tanatani; Hisayoshi Kobayashi; Rumiko Shimazawa; Hiroyuki Koshino; Yuichi Hashimoto; Kazuo Nagasawa
Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist.
Bioorganic & medicinal chemistry letters 2004;14(10):2579-83.
2004: Rumiko Shimazawa; Hiroko Sano; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto
Thalidomide as a nitric oxide synthase inhibitor and its structural development.
Chemical & pharmaceutical bulletin 2004;52(4):498-9.
2004: Yoshihiro Sohtome; Aya Tanatani; Yuichi Hashimoto; Kazuo Nagasawa
Development of novel chiral urea catalysts for the hetero-Michael reaction.
Chemical & pharmaceutical bulletin 2004;52(4):477-80.
2004: Jun Shimokawa; Koji Shirai; Aya Tanatani; Yuichi Hashimoto; Kazuo Nagasawa
Enantioselective total synthesis of batzelladine A.
Angewandte Chemie (International ed. in English) 2004;43(12):1559-62.
2004: Yuichi Hashimoto; Takahiko Matsuda; Yoshiharu Matsuura; Tatsuya Haga; Yoshitaka Fukada
Production of N-lauroylated G protein alpha-subunit in Sf9 insect cells: the type of N-acyl group of Galpha influences G protein-mediated signal transduction.
Journal of biochemistry 2004;135(3):319-29.
2003: Naoko Morisaki; Hisayoshi Kobayashi; Kazuo Nagasawa; Yoshiyasu Baba; Mikiko Sodeoka; Yuichi Hashimoto
Conversion of Ca2+ salt of an organic compound to its Li+ salt to simplify the fast atom bombardment mass spectrum.
Chemical & pharmaceutical bulletin 2003;51(11):1341-4.
2003: Hiroki Kakuta; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto
Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.
Chemical & pharmaceutical bulletin 2003;51(11):1273-82.
2003: Mamiko Suizu; Yohei Muroya; Hiroki Kakuta; Hiroyuki Kagechika; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto
Cyclooxygenase inhibitors derived from thalidomide.
Chemical & pharmaceutical bulletin 2003;51(9):1098-102.
2003: Toshiyasu Ishioka; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto
Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.
Bioorganic & medicinal chemistry letters 2003;13(16):2655-8.
2003: Yuichi Hashimoto
Structural development of synthetic retinoids and thalidomide-related molecules.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S16-23.
2003: Hiroki Kakuta; Yukiko Koiso; Kazuo Nagasawa; Yuichi Hashimoto
Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.
Bioorganic & medicinal chemistry letters 2003;13(1):83-6.
2003: Kazuo Nagasawa; Yuichi Hashimoto
Synthesis of marine guanidine alkaloids and their application as chemical/biological tools.
Chemical record (New York, N.Y.) 2003;3(4):201-11.
2002: Yuichi Hashimoto
Structural development of biological response modifiers based on retinoids and thalidomide.
Mini reviews in medicinal chemistry 2002;2(6):543-51.
2002: Takanori Ishiwata; Tomoyuki Hino; Hiroyuki Koshino; Yuichi Hashimoto; Tadashi Nakata; Kazuo Nagasawa
Total synthesis of batzelladine D.
Organic letters 2002;4(17):2921-4.
2002: Tetsuya Kita; Angelina Georgieva; Yuichi Hashimoto; Tadashi Nakata; Kazuo Nagasawa
C(2)-symmetric chiral pentacyclic guanidine: a phase-transfer catalyst for the asymmetric alkylation of tert-butyl glycinate Schiff base.
Angewandte Chemie (International ed. in English) 2002;41(15):2832-4.
2002: Bitoku Takahashi; Kiminori Ohta; Emiko Kawachi; Hiroshi Fukasawa; Yuichi Hashimoto; Hiroyuki Kagechika
Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
Journal of medicinal chemistry 2002;45(16):3327-30.
2002: Naoko Morisaki; Hisayoshi Kobayashi; Yumiko Yamamura; Masuo Morisaki; Kazuo Nagasawa; Yuichi Hashimoto
Coordination of sodium cation to an oxygen function and olefinic double bond to form molecular adduct ion in fast atom bombardment mass spectrometry.
Chemical & pharmaceutical bulletin 2002;50(7):935-40.
2002: Toshiyasu Ishioka; Asako Kubo; Yukiko Koiso; Kazuo Nagasawa; Akiko Itai; Yuichi Hashimoto
Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety.
Bioorganic & medicinal chemistry 2002;10(5):1555-66.
2002: Tomomi Noguchi; Rumiko Shimazawa; Kazuo Nagasawa; Yuichi Hashimoto
Thalidomide and its analogues as cyclooxygenase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(7):1043-6.
2002: Yuichi Hashimoto
Structural development of biological response modifiers based on thalidomide.
Bioorganic & medicinal chemistry 2002;10(3):461-79.
2002: Kazuo Nagasawa; Angelina Georgieva; Hiroyuki Koshino; Tadashi Nakata; Tetsuya Kita; Yuichi Hashimoto
Total synthesis of crambescidin 359.
Organic letters 2002;4(2):177-80.
2001: Hiroshi Noto; Yuichi Hashimoto; Hitoshi Satoh; Masumi Hara; Naoyuki Iso-o; Masako Togo; Satoshi Kimura; Kazuhisa Tsukamoto
Exclusive association of paraoxonase 1 with high-density lipoprotein particles in apolipoprotein A-I deficiency.
Biochemical and biophysical research communications 2001;289(2):395-401.
2001: Yuichi Hashimoto; Azusa Futamura; Hideo Nakarai; Kazuhiko Nakahara
Relationship between response of gamma-glutamyl transpeptidase to alcohol drinking and risk factors for coronary heart disease.
Atherosclerosis 2001;158(2):465-70.
2001: Ryoichi Saito; Yuichi Hashimoto; Azusa Futamura; Nobuko Watanabe; Fumiko Mashige; Hideo Nakarai; Kazuhiko Nakahara
[Reference intervals of urinary biochemical analysis in Japanese men].
Rinsho byori. The Japanese journal of clinical pathology 2001;49(7):707-10.
2001: T Kita; H Takahashi; Yuichi Hashimoto
Thymidine phosphorylase inhibitors with a homophthalimide skeleton.
Biological & pharmaceutical bulletin 2001;24(7):860-2.
2001: S Sou; H Takahashi; Ryu Yamasaki; Hiroyuki Kagechika; Y Endo; Yuichi Hashimoto
Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.
Chemical & pharmaceutical bulletin 2001;49(6):791-3.
2001: Motohiro Ebisawa; Keisuke Ohta; Emiko Kawachi; Hiroshi Fukasawa; Yuichi Hashimoto; Hiroyuki Kagechika
Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure.
Chemical & pharmaceutical bulletin 2001;49(4):501-3.
2001: H Takahashi; Yuichi Hashimoto
Formaldehyde-mediated modification of natural deoxyguanosine with amines: one-pot cyclization as a molecular model for genotoxicity.
Bioorganic & medicinal chemistry letters 2001;11(5):729-31.
2001: Naoko Morisaki; Yuichi Hashimoto; Kazuo Furihata; Katsukiyo Yazawa; M Tamura; Yuzuru Mikami
Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain.
The Journal of antibiotics 2001;54(2):157-65.
2001: Masako Togo; T Toda; L A Nguyen; S Kubota; Kazuhisa Tsukamoto; Hitoshi Satoh; Masumi Hara; Naoyuki Iso-o; Hiroshi Noto; Satoshi Kimura; K Nakahara; Y Seyama; Yuichi Hashimoto
Genetic analysis of phytosterolaemia.
Journal of inherited metabolic disease 2001;24(1):43-50.
2001: Mikiko Sodeoka; R Sampe; S Kojima; Yoshiyasu Baba; Naoko Morisaki; Yuichi Hashimoto
Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography.
Chemical & pharmaceutical bulletin 2001;49(2):206-12.
2001: Yuichi Hashimoto; Azusa Futamura; Hideo Nakarai; Kazuhiko Nakahara
Effects of the frequency of alcohol intake on risk factors for coronary heart disease.
European journal of epidemiology 2001;17(4):307-12.
2001: Masato Komoda; Hiroki Kakuta; H Takahashi; Yoshinori Fujimoto; S Kadoya; F Kato; Yuichi Hashimoto
Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study.
Bioorganic & medicinal chemistry 2001;9(1):121-31.
2000: K Hara; H Kudoh; Takemi Enomoto; Yuichi Hashimoto; T Masuko
Enhanced tumorigenicity caused by truncation of the extracellular domain of GP125/CD98 heavy chain.
Oncogene 2000;19(54):6209-15.
2000: Hiroshi Fukasawa; Mitsune Yamaguchi; Yuichi Hashimoto; Yaeta Endo; Koichi Shudo
Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription.
Biological & pharmaceutical bulletin 2000;23(12):1414-7.
2000: M Takahashi; Kosuke Dodo; Y Sugimoto; Y Aoyagi; Y Yamada; Yuichi Hashimoto; Ryuichi Shirai
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
Bioorganic & medicinal chemistry letters 2000;10(22):2571-4.
2000: H Takahashi; Toshiyasu Ishioka; Yukiko Koiso; Mikiko Sodeoka; Yuichi Hashimoto
Anti-androgenic activity of substituted azo- and azoxy-benzene derivatives.
Biological & pharmaceutical bulletin 2000;23(11):1387-90.
2000: H Takahashi; Masato Komoda; Hiroki Kakuta; Yuichi Hashimoto
[Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2000;120(10):909-21.
2000: Keisuke Ohta; Emiko Kawachi; N Inoue; Hiroshi Fukasawa; Yuichi Hashimoto; Akiko Itai; Hiroyuki Kagechika
Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids.
Chemical & pharmaceutical bulletin 2000;48(10):1504-13.
2000: H Takahashi; S Sou; Ryu Yamasaki; Mikiko Sodeoka; Yuichi Hashimoto
Alpha-glucosidase inhibitors with a phthalimide skeleton: structure-activity relationship study.
Chemical & pharmaceutical bulletin 2000;48(10):1494-9.
2000: Nobuko Watanabe; Yuichi Hashimoto; K Okamoto; Fumiko Mashige; Kazuhiko Nakahara
[Glioblastoma with a marked elevation of total protein and albumin in the cerebrospinal fluid].
Rinsho byori. The Japanese journal of clinical pathology 2000;48(9):877-9.
2000: Satoshi Mayumi; A Azuma; H Kobayashi; Mikiko Sodeoka; K Yano; S Sugimoto; Y Endo; Yuichi Hashimoto
Identification of protein disulfide isomerase as a phorbol ester-binding protein.
Biological & pharmaceutical bulletin 2000;23(9):1111-3.
2000: Naoko Morisaki; M Masaoka; Ryuichi Shirai; Yuichi Hashimoto
Separation of phosphatidylinositol 4-phosphate from a mixture with phosphatidylserine and phosphatidylinositol by Sep-Pak C18 cartridge.
Biological & pharmaceutical bulletin 2000;23(9):1088-9.
2000: T Shishido; S Uno; M Kamohara; T Tsuneoka-Suzuki; Yuichi Hashimoto; Takemi Enomoto; T Masuko
Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity.
International journal of cancer. Journal international du cancer 2000;87(3):311-6.
2000: S Sou; Satoshi Mayumi; H Takahashi; Ryu Yamasaki; S Kadoya; Mikiko Sodeoka; Yuichi Hashimoto
Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.
Bioorganic & medicinal chemistry letters 2000;10(10):1081-4.
2000: Kosuke Dodo; M Takahashi; Y Yamada; Y Sugimoto; Yuichi Hashimoto; Ryuichi Shirai
Synthesis of a novel class of cdc25A inhibitors from vitamin D3.
Bioorganic & medicinal chemistry letters 2000;10(7):615-7.
2000: T Matsumoto; Koutaro Yokote; Ayako Take; Minoru Takemoto; Sunao Asaumi; Yuichi Hashimoto; M Matsuda; Yasushi Saito; Seijiro Mori
Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.
Biochemical and biophysical research communications 2000;270(1):28-33.
2000: M Tsuji; Yukiko Koiso; H Takahashi; Yuichi Hashimoto; Yaeta Endo
Modulators of tumor necrosis factor alpha production bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.
Biological & pharmaceutical bulletin 2000;23(4):513-6.
2000: Naoko Morisaki; Yuichi Hashimoto; Kazuo Furihata; T Imai; K Watanabe; Yuzuru Mikami; Katsukiyo Yazawa; Akikazu Ando; Y Nagata; Eric R Dabbs
Structures of ADP-ribosylated rifampicin and its metabolite: intermediates of rifampicin-ribosylation by Mycobacterium smegmatis DSM43756.
The Journal of antibiotics 2000;53(3):269-75.
2000: T Shishido; M Ohkawa; A Itoh; Takemi Enomoto; Yuichi Hashimoto; T Masuko
Colocalization of GP125/CD98 with tropomyosin isoforms at the cell-cell adhesion boundary.
Journal of biochemistry 2000;127(2):253-61.
2000: Masako Togo; Yuichi Hashimoto; Azusa Futamura; Kazuhisa Tsukamoto; H Satoh; Masako Hara; T Watanabe; Hideo Nakarai; Kazuhiko Nakahara; Satoshi Kimura
Relationship between the serum level of leptin and life-style habits in Japanese men.
Hormone research 2000;54(4):169-73.
2000: M Minagawa; T Yasuda; T Someya; Y Kohno; Naokatsu Saeki; Yuichi Hashimoto
Effects of octreotide infusion, surgery and estrogen on suppression of height increase and 20K growth hormone ratio in a girl with gigantism due to a growth hormone-secreting macroadenoma.
Hormone research 2000;53(3):157-60.
2000: Yukiko Koiso; O Nakajima; Daisuke Matsumura; Yoshinori Fujimoto; Yuichi Hashimoto
[Chemical control of cell differentiation of human myeloleukemia K562 cell line].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2000;120(1):104-12.
1999: Motohiro Ebisawa; H Umemiya; Keisuke Ohta; Hiroshi Fukasawa; Emiko Kawachi; G Christoffel; Hinrich Gronemeyer; M Tsuji; Yuichi Hashimoto; Koichi Shudo; Hiroyuki Kagechika
Retinoid X receptor-antagonistic diazepinylbenzoic acids.
Chemical & pharmaceutical bulletin 1999;47(12):1778-86.
1999: K Hara; H Kudoh; Takemi Enomoto; Yuichi Hashimoto; T Masuko
Malignant transformation of NIH3T3 cells by overexpression of early lymphocyte activation antigen CD98.
Biochemical and biophysical research communications 1999;262(3):720-5.
1999: Hiroyuki Kagechika; Masato Komoda; Yoshinori Fujimoto; Yukiko Koiso; Hiroaki Takayama; S Kadoya; K Miyata; F Kato; Masatoshi Kato; Yuichi Hashimoto
Potent homophthalimide-type inhibitors of B16F10/L5 mouse melanoma cell invasion.
Biological & pharmaceutical bulletin 1999;22(9):1010-2.
1999: Y Matsumoto; K Satoh-Ueno; A Yoshimura; Yuichi Hashimoto; Takemi Enomoto; T Masuko
Identification and immunological characterization of a novel 40-kDa protein linked to CD98 antigen.
Cell structure and function 1999;24(4):217-26.
1999: Yoshinori Fujimoto; R Nagata; Hisayoshi Kobayashi; Koichi Shudo; Yuichi Hashimoto
[Molecular identification of cytokinin-specific binding protein].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1999;119(8):612-23.
1999: Azusa Futamura; Yuichi Hashimoto; S Okubo; T Aihara; H Watanabe; A Fujita; M Koda; Kazuhiko Nakahara
[Urine C-peptide excretion in hypocaloric states and factors affecting its excretion].
Rinsho byori. The Japanese journal of clinical pathology 1999;47(6):566-70.
1999: S Okubo; Yuichi Hashimoto; Azusa Futamura; Nobuko Watanabe; H Mashige; A Fujita; M Koda; Kazuhiko Nakahara
[Effects of a 5-day fast on clinical laboratory data from patients with rheumatoid arthritis].
Rinsho byori. The Japanese journal of clinical pathology 1999;47(6):561-5.
1999: Yukiko Koiso; Yoshinori Fujimoto; Daisuke Matsumura; O Nakajima; Yuichi Hashimoto
Modification by heme oxygenase inhibitor, tin protoporphyrin, of cellular differentiation of human myeloid leukemia K562 cell line.
Biological & pharmaceutical bulletin 1999;22(4):439-40.
1999: S Okubo; Yuichi Hashimoto; Azusa Futamura; K Morita; H Mashige; Hideo Nakarai; Kazuhiko Nakahara
[Comparison of LDL-C values measured with the automated method and the ultracentrifugation method in severe hypertriglyceridemia, and prevalence and life-style of patients with hypertriglyceridemia].
Rinsho byori. The Japanese journal of clinical pathology 1999;47(3):275-80.
1999: Nobuko Watanabe; Yuichi Hashimoto; Azusa Futamura; Fumiko Mashige; Hideo Nakarai; Kazuhiko Nakahara
[Relationship between the prevalence of proteinuria and obesity in Japanese men].
Rinsho byori. The Japanese journal of clinical pathology 1999;47(3):271-4.
1999: Rumiko Shimazawa; Hiroaki Takayama; F Kato; Masatoshi Kato; Yuichi Hashimoto
Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.
Bioorganic & medicinal chemistry letters 1999;9(4):559-62.
1999: Rumiko Shimazawa; Hiroyuki Miyachi; Hiroaki Takayama; K Kuroda; F Kato; Masatoshi Kato; Yuichi Hashimoto
Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide.
Biological & pharmaceutical bulletin 1999;22(2):224-6.
1999: Hitoshi Satoh; Kazuhisa Tsukamoto; Yuichi Hashimoto; N Hashimoto; Masako Togo; Masumi Hara; Hisato Maekawa; N Isoo; Satoshi Kimura; Tomomi Watanabe
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.
Biochemical and biophysical research communications 1999;254(3):757-63.
1999: T Imai; K Watanabe; Yuzuru Mikami; Katsukiyo Yazawa; Akikazu Ando; Y Nagata; Naoko Morisaki; Yuichi Hashimoto; Kazuo Furihata; Eric R Dabbs
Identification and characterization of a new intermediate in the ribosylative inactivation pathway of rifampin by Mycobacterium smegmatis.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(4):259-64.
1999: Rumiko Shimazawa; Hiroaki Takayama; Yoshinori Fujimoto; Masato Komoda; Kosuke Dodo; Ryu Yamasaki; Ryuichi Shirai; Yukiko Koiso; K Miyata; F Kato; Masatoshi Kato; Hiroyuki Miyachi; Yuichi Hashimoto
Novel small molecule nonpeptide aminopeptidase n inhibitors with a cyclic imide skeleton.
Journal of enzyme inhibition 1999;14(4):259-75.
1999: Yuichi Hashimoto; Azusa Futamura; Nobuko Watanabe; Masako Togo; H Sato; Masako Hara; Kazuhisa Tsukamoto; Satoshi Kimura; Kazuhiko Nakahara
Relationship between glycosylated hemoglobin and the prevalence of proteinuria in Japanese men.
Internal medicine (Tokyo, Japan) 1999;38(1):6-11.
1999: S Quan; T Imai; Yuzuru Mikami; Katsukiyo Yazawa; Eric R Dabbs; Naoko Morisaki; S Iwasaki; Yuichi Hashimoto; Kazuo Furihata
ADP-ribosylation as an intermediate step in inactivation of rifampin by a mycobacterial gene.
Antimicrobial agents and chemotherapy 1999;43(1):181-4.
1998: Yoshinori Fujimoto; R Nagata; H Fukasawa; K Yano; M Azuma; A Iida; S Sugimoto; Koichi Shudo; Yuichi Hashimoto
Purification and cDNA cloning of cytokinin-specific binding protein from mung bean (Vigna radiata).
European journal of biochemistry / FEBS 1998;258(2):794-802.
1998: Ryuichi Shirai; Hiroaki Takayama; A Nishikawa; Yukiko Koiso; Yuichi Hashimoto
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
Bioorganic & medicinal chemistry letters 1998;8(15):1997-2000.
1998: Misako Hangaishi; Junichi Taguchi; Toshiyuki Miyata; Yuji Ikari; Masako Togo; Yuichi Hashimoto; Tomomi Watanabe; Satoshi Kimura; Kiyoshi Kurokawa; Minoru Ohno
Increased aggregation of human platelets produced by advanced glycation end products in vitro.
Biochemical and biophysical research communications 1998;248(2):285-92.
1998: Takahiko Matsuda; Yuichi Hashimoto; H Ueda; Tomoichiro Asano; Yoshiharu Matsuura; T Doi; Toshifumi Takao; Y Shimonishi; Yoshitaka Fukada
Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.
Biochemistry 1998;37(27):9843-50.
1998: Hiroyuki Miyachi; Yukiko Koiso; Ryuichi Shirai; S Niwayama; Jun O Liu; Yuichi Hashimoto
Tumor necrosis factor-alpha production enhancing activity of substituted 3'-methylthalidomide: influence of substituents at the phthaloyl moiety on the activity and stereoselectivity.
Chemical & pharmaceutical bulletin 1998;46(7):1165-8.
1998: Yuichi Hashimoto
Novel biological response modifiers derived from thalidomide.
Current medicinal chemistry 1998;5(3):163-78.
1998: S Niwayama; C Loh; B E Turk; Jun O Liu; Hiroyuki Miyachi; Yuichi Hashimoto
Enhanced potency of perfluorinated thalidomide derivatives for inhibition of LPS-induced tumor necrosis factor-alpha production is associated with a change of mechanism of action.
Bioorganic & medicinal chemistry letters 1998;8(9):1071-6.
1998: Motohiro Ebisawa; Emiko Kawachi; Hiroshi Fukasawa; Yuichi Hashimoto; Akiko Itai; Koichi Shudo; Hiroyuki Kagechika
Novel thiazolidinedione derivatives with retinoid synergistic activity.
Biological & pharmaceutical bulletin 1998;21(5):547-9.
1998: Keisuke Ohta; M Tsuji; Emiko Kawachi; Hiroshi Fukasawa; Yuichi Hashimoto; Koichi Shudo; Hiroyuki Kagechika
Potent retinoid synergists with a diphenylamine skeleton.
Biological & pharmaceutical bulletin 1998;21(5):544-6.
1998: T Shirai; Keiichi Tanaka; Yoshio Terada; T Sawada; R Shirai; Yuichi Hashimoto; Satoshi Nagata; Akihiro Iwamatsu; K Okawa; S Li; S Hattori; H Mano; Yasuhisa Fukui
Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins.
Biochimica et biophysica acta 1998;1402(3):292-302.
1998: Naoko Morisaki; Y Mitsui; Y Yamashita; Yukiko Koiso; Ryuichi Shirai; Yuichi Hashimoto; S Iwasaki
Synthesis and anti-tubulin activity of ustiloxin D derivatives.
The Journal of antibiotics 1998;51(4):423-7.
1998: Yukiko Koiso; Naoko Morisaki; Y Yamashita; Y Mitsui; Ryuichi Shirai; Yuichi Hashimoto; S Iwasaki
Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous peptide, ustiloxin B.
The Journal of antibiotics 1998;51(4):418-22.
1998: Hiroyuki Miyachi; Masatoshi Kato; F Kato; Yuichi Hashimoto
Novel potent nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton.
Journal of medicinal chemistry 1998;41(3):263-5.
1998: Ryuichi Shirai; T Ito; S Iwasaki; Yuichi Hashimoto
Sequence selective interaction between nucleotides and intercalators bound to water soluble dextran: an application to the affinity chromatography of dinucleotides.
Nucleosides & nucleotides 1998;17(1-3):593-601.
1998: Yuichi Hashimoto; T Sasaki
Photoaffinity labeling of RARs and mapping of labeled sites by an endoproteinase combination technique.
Methods in molecular biology (Clifton, N.J.) 1998;89():293-305.
1997: H Umemiya; Hiroshi Fukasawa; Motohiro Ebisawa; L Eyrolles; Emiko Kawachi; G Eisenmann; Hinrich Gronemeyer; Yuichi Hashimoto; Koichi Shudo; Hiroyuki Kagechika
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Journal of medicinal chemistry 1997;40(26):4222-34.
1997: Hiroyuki Miyachi; A Ogasawara; A Azuma; Yuichi Hashimoto
Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study.
Bioorganic & medicinal chemistry 1997;5(11):2095-102.
1997: Toshihiko Tashima; Hiroyuki Kagechika; M Tsuji; Hiroshi Fukasawa; Emiko Kawachi; Yuichi Hashimoto; Koichi Shudo
Polyenylidene thiazolidinedione derivatives with retinoidal activities.
Chemical & pharmaceutical bulletin 1997;45(11):1805-13.
1997: Hitoshi Satoh; Masako Togo; Masumi Hara; Toshiyuki Miyata; K Han; Hisato Maekawa; Minoru Ohno; Yuichi Hashimoto; Kiyoshi Kurokawa; Tomomi Watanabe
Advanced glycation endproducts stimulate mitogen-activated protein kinase and proliferation in rabbit vascular smooth muscle cells.
Biochemical and biophysical research communications 1997;239(1):111-5.
1997: Yuichi Hashimoto; Masako Togo; Hiroshi Sato; N Hashimoto; Tomomi Watanabe; Kiyoshi Kurokawa; K Nakahara
Characteristics of protein kinase C-independent exocytosis in human platelets.
Thrombosis research 1997;88(1):51-8.
1997: Hiroyuki Miyachi; A Azuma; A Ogasawara; E Uchimura; N Watanabe; Y Kobayashi; F Kato; Masatoshi Kato; Yuichi Hashimoto
Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity.
Journal of medicinal chemistry 1997;40(18):2858-65.
1997: T Sasaki; Naoko Morisaki; S Iwasaki; Hiroyuki Kagechika; Hiroshi Fukasawa; Koichi Shudo; Y Shida; Yuichi Hashimoto
Photoaffinity labeling of the ligand-interacting helix of the retinoic acid receptor alpha.
Biological & pharmaceutical bulletin 1997;20(8):913-6.
1997: Masato Kubo; J Ransom; D Webb; Yuichi Hashimoto; T Tada; Toshinori Nakayama
T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6.
The EMBO journal 1997;16(13):4007-20.
1997: Keiichi Tanaka; S Imajoh-Ohmi; T Sawada; R Shirai; Yuichi Hashimoto; S Iwasaki; Kozo Kaibuchi; Yasunori Kanaho; T Shirai; Yoshio Terada; K Kimura; Satoshi Nagata; Yasuhisa Fukui
A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains.
European journal of biochemistry / FEBS 1997;245(2):512-9.
1997: H Umemiya; Hiroyuki Kagechika; Hiroshi Fukasawa; Emiko Kawachi; Motohiro Ebisawa; Yuichi Hashimoto; G Eisenmann; C Erb; A Pornon; Pierre Chambon; Hinrich Gronemeyer; Koichi Shudo
Action mechanism of retinoid-synergistic dibenzodiazepines.
Biochemical and biophysical research communications 1997;233(1):121-5.
1997: Hiroyuki Kagechika; Emiko Kawachi; Hiroshi Fukasawa; Gunzi Saito; Norimasa Iwanami; H Umemiya; Yuichi Hashimoto; Koichi Shudo
Inhibition of IL-1-induced IL-6 production by synthetic retinoids.
Biochemical and biophysical research communications 1997;231(2):243-8.
1997: Hisayoshi Kobayashi; Naoko Morisaki; Y Tago; Yuichi Hashimoto; S Iwasaki; Emiko Kawachi; R Nagata; Koichi Shudo
Structural identification of a major cytokinin in coconut milk as 14-O-(3-O-[beta-D-galactopyranosyl-(1-->2)-alpha-D-galactopyranosyl- (1-->3)-alpha-L-arabinofuranosyl]-4-O-(alpha-L-arabinofuranosyl)- beta-d-galactopyranosyl)-trans-zeatin riboside.
Chemical & pharmaceutical bulletin 1997;45(2):260-4.
1997: Hiroyuki Miyachi; A Azuma; Yuichi Hashimoto
[Novel biological response modifiers: phthalimides with TNF-alpha production regulating activity].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1997;117(2):91-107.
1997: O Nakajima; S Iwasaki; Yuichi Hashimoto
Hemin-induced erythroid differentiation of human myeloleukemia K562 cell line and its modification by bioresponse modifiers.
Cellular and molecular biology (Noisy-le-Grand, France) 1997;43(1):115-34.
1997: K Morita; Yukiko Koiso; Yuichi Hashimoto; M Kobayashi; W Wang; N Ohyabu; S Iwasaki
Interaction of arenastatin A with porcine brain tubulin.
Biological & pharmaceutical bulletin 1997;20(2):171-4.
1997: T Ito; Ryuichi Shirai; Yuichi Hashimoto; S Iwasaki
Non-intercalative and sequence selective interaction between four intercalative reagents and dinucleotides.
Nucleic acids symposium series 1997;(37):79-80.
1997: A Azuma; Y Ando; S Iwasaki; Yuichi Hashimoto; Mitsune Yamaguchi; S Takehana; Hiroshi Fukasawa; Yaeta Endo; Koichi Shudo
Photoaffinity labeling of tumor promoter-binding protein (CN-TPBP) and preparation of affinity sorbent gels.
Biological & pharmaceutical bulletin 1997;20(1):6-9.
1996: H Umemiya; Hiroyuki Kagechika; Hiroshi Fukasawa; Yuichi Hashimoto; Koichi Shudo
[Retinoid antagonists].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1996;116(12):928-41.
1996: T Watanabe; Shinji Sunaga; Masako Togo; Hitoshi Satoh; Masaaki Higashihara; Yuichi Hashimoto; Kiyoshi Kurokawa
Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s.
Biochimica et biophysica acta 1996;1304(2):161-9.
1996: T Watanabe; Hitoshi Satoh; M Togoh; S Taniguchi; Yuichi Hashimoto; Kiyoshi Kurokawa
Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells.
Journal of cellular physiology 1996;169(2):401-9.
1996: Yuichi Hashimoto; Koichi Shudo
Chemistry of biologically active benzoxazinoids.
Phytochemistry 1996;43(3):551-9.
1996: Yuichi Hashimoto; Hiroyuki Kagechika; Emiko Kawachi; Hiroshi Fukasawa; G Saito; Koichi Shudo
Evaluation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Biological & pharmaceutical bulletin 1996;19(10):1322-8.
1996: R Fukutomi; Hiroyuki Kagechika; Yuichi Hashimoto; Koichi Shudo
Novel aromatic urea derivatives with DNA-binding ability.
Chemical & pharmaceutical bulletin 1996;44(10):1983-5.
1996: Hiroyuki Miyachi; A Azuma; E Hioki; Y Kobayashi; S Iwasaki; Yuichi Hashimoto
Inducer-specific regulators of tumor necrosis factor alpha production.
Chemical & pharmaceutical bulletin 1996;44(10):1980-2.
1996: Hiroyuki Miyachi; A Azuma; E Hioki; S Iwasaki; Y Kobayashi; Yuichi Hashimoto
Cell type-/inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production and its enantio-dependence.
Biochemical and biophysical research communications 1996;226(2):439-44.
1996: Hiroyuki Miyachi; A Azuma; E Hioki; S Iwasaki; Y Kobayashi; Yuichi Hashimoto
Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production.
Biochemical and biophysical research communications 1996;224(2):426-30.
1996: T Nakayama; Yuichi Hashimoto; Y Kaneko; Kiyoshi Kurokawa
K252a inhibits the phosphorylation of pRb without changing the levels of G1 cyclins and Cdk2 protein in human hepatoma cells.
Biochemical and biophysical research communications 1996;224(1):180-3.
1996: A Azuma; Hiroyuki Miyachi; Y Shibata; Yuichi Hashimoto; S Iwasaki
Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message.
Biological & pharmaceutical bulletin 1996;19(7):1001-3.
1996: T Sasaki; Rumiko Shimazawa; T Sawada; T Iljima; Hiroshi Fukasawa; Koichi Shudo; Yuichi Hashimoto; S Iwasaki
Location of two photoaffinity-labeled sites on the ligand-binding domain of retinoic acid receptor alpha.
Biological & pharmaceutical bulletin 1996;19(5):659-64.
1996: N Iwanami; Yuichi Hashimoto; Koichi Shudo
meso-DNAs with homopurine sequences: analysis of their interaction with natural DNAs.
Chemical & pharmaceutical bulletin 1996;44(5):919-26.
1996: Y Shibata; K Sasaki; Yuichi Hashimoto; S Iwasaki
Phenylphthalimides with tumor necrosis factor alpha production-enhancing activity.
Chemical & pharmaceutical bulletin 1996;44(1):156-62.
1995: Hisayoshi Kobayashi; N Morisaki; Y Tago; Yuichi Hashimoto; S Iwasaki; Emiko Kawachi; R Nagata; Koichi Shudo
Identification of a major cytokinin in coconut milk.
Experientia 1995;51(11):1081-4.
1995: Yuichi Hashimoto; Azusa Futamura; M Ikushima
Effect of aging on HbA1c in a working male Japanese population.
Diabetes care 1995;18(10):1337-40.
1995: H Umemiya; Emiko Kawachi; Hiroyuki Kagechika; Hiroshi Fukasawa; Yuichi Hashimoto; Koichi Shudo
Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60.
Chemical & pharmaceutical bulletin 1995;43(10):1827-9.
1995: S Hagiwara; T Sakurai; Fumi Tashiro; Yuichi Hashimoto; Yoshihiro Matsuda; Yoshinori Nonomura; J Miyazaki
An inhibitory role for phosphatidylinositol 3-kinase in insulin secretion from pancreatic B cell line MIN6.
Biochemical and biophysical research communications 1995;214(1):51-9.
1995: K Sasaki; Y Shibata; Yuichi Hashimoto; S Iwasaki
Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor alpha.
Biological & pharmaceutical bulletin 1995;18(9):1228-33.
1995: O Nakajima; Yuichi Hashimoto; S Iwasaki
Possible involvement of peripheral-type benzodiazepine receptors in erythroid differentiation of human leukemia cell line, K562.
Biological & pharmaceutical bulletin 1995;18(6):903-6.
1995: Y Li; Yukiko Koiso; H Kobayashi; Yuichi Hashimoto; S Iwasaki
Ustiloxins, new antimitotic cyclic peptides: interaction with porcine brain tubulin.
Biochemical pharmacology 1995;49(10):1367-72.
1995: M Shichita; Rumiko Shimazawa; O Nakajima; H Mizoguchi; Yuichi Hashimoto; S Iwasaki
Non-intercalative and sequence-selective interaction of nitropyrene/acridine-skeleton with nucleotides: application of the dextran-coupling method.
Biological & pharmaceutical bulletin 1995;18(4):637-9.
1995: Yuichi Hashimoto; T Ishizaki; Koichi Shudo
[Chemistry of benzoxazinoids produced by plants as phytoalexin].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1995;115(3):189-200.
1995: T Sasaki; Rumiko Shimazawa; T Sawada; T Iijima; Hiroshi Fukasawa; Koichi Shudo; Yuichi Hashimoto; S Iwasaki
Determination of the photoaffinity-labeled site on the ligand-binding domain of retinoic acid receptor alpha.
Biochemical and biophysical research communications 1995;207(1):444-51.
1995: O Nakajima; Hiroyuki Kagechika; Koichi Shudo; Yuichi Hashimoto; S Iwasaki
Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.
Biochemical and biophysical research communications 1995;206(3):1003-10.
1995: Ryuichi Shirai; Rumiko Shimazawa; M Shichita; M Takahashi; Yuichi Hashimoto; S Iwasaki
Cytotoxicity and DNA-binding property of non-diynene class of dynemicins and aza-anthraquinones.
Nucleic acids symposium series 1995;(34):151-2.
1995: O Nakajima; M Shichita; S Iwasaki; Yuichi Hashimoto
Application of the dextran coupling method for analysis of interactions between intercalators and nucleotides.
Nucleic acids symposium series 1995;(34):137-8.
1995: H Umemiya; K Komatsu; T Yamazaki; Hiroyuki Kagechika; Koichi Shudo; Yuichi Hashimoto
Synthesis of oligopeptides as polynucleotide analogs.
Nucleic acids symposium series 1995;(34):37-8.
1995: Y Shibata; M Shichita; K Sasaki; K Nishimura; Yuichi Hashimoto; S Iwasaki
N-Alkylphthalimides: structural requirement of thalidomidal action on 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by human leukemia HL-60 cells.
Chemical & pharmaceutical bulletin 1995;43(1):177-9.
1995: Yuichi Hashimoto; Hiroyuki Kagechika; Emiko Kawachi; Hiroshi Fukasawa; G Saito; Koichi Shudo
Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Journal of cancer research and clinical oncology 1995;121(11):696-8.
1994: Y Shibata; K Sasaki; Yuichi Hashimoto; S Iwasaki
Tumor necrosis factor alpha production enhancers with a phenylphthalimide skeleton.
Biochemical and biophysical research communications 1994;205(3):1992-7.
1994: Y Li; H Kobayashi; Yuichi Hashimoto; Ryuichi Shirai; A Hirata; K Hayashi; Y Hamada; T Shioiri; S Iwasaki
Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding.
Chemico-biological interactions 1994;93(3):175-83.
1994: L Eyrolles; Emiko Kawachi; Hiroyuki Kagechika; Yuichi Hashimoto; Koichi Shudo
Synthesis and biological activity of carboxyphenylquinolines and related compounds as new potent retinoids. Retinobenzoic acids. VII.
Chemical & pharmaceutical bulletin 1994;42(12):2575-81.
1994: Y Shibata; K Sasaki; K Nishimura; Yuichi Hashimoto; S Iwasaki
Enhancement of phorbol ester-induced production of tumor necrosis factor-alpha by 2,6-dimethylphenylphthalimide.
Biological & pharmaceutical bulletin 1994;17(11):1532-4.
1994: Yuichi Hashimoto; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Nitrile hydratase gene from Rhodococcus sp. N-774 requirement for its downstream region for efficient expression.
Bioscience, biotechnology, and biochemistry 1994;58(10):1859-65.
1994: Yuichi Hashimoto; H Sasaki; Masako Togo; Kazuhisa Tsukamoto; Y Horie; H Fukata; T Watanabe; Kiyoshi Kurokawa
Roles of myosin light-chain kinase in platelet shape change and aggregation.
Biochimica et biophysica acta 1994;1223(2):163-9.
1994: K Sasaki; Y Shibata; K Nishimura; Yuichi Hashimoto; S Iwasaki
Enhancement of 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by phenethylphthalimide analogs.
Biological & pharmaceutical bulletin 1994;17(9):1313-5.
1994: Y Matsushima; Hiroshi Fukasawa; Y Endo; Yuichi Hashimoto; Koichi Shudo
Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol.
Biological & pharmaceutical bulletin 1994;17(9):1292-5.
1994: H Mizoguchi; Hiroshi Fukasawa; A Steuernagel; K Yano; M Yamasaki; S Iwasaki; Yuichi Hashimoto
Specific binding of 12-O-tetradecanoylphorbol-13-acetate to histone H1.
Biological & pharmaceutical bulletin 1994;17(8):1114-7.
1994: T Watanabe; Akihide Nakao; D Emerling; Yuichi Hashimoto; K Tsukamoto; Y Horie; M Kinoshita; Kiyoshi Kurokawa
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
The Journal of biological chemistry 1994;269(26):17619-25.
1994: T Suzuki; Makoto Murakami; N Onai; E Fukuda; Yuichi Hashimoto; M H Sonobe; T Kameda; M Ichinose; K Miki; Hideo Iba
Analysis of AP-1 function in cellular transformation pathways.
Journal of virology 1994;68(6):3527-35.
1994: Yuichi Hashimoto
[Chemical control of gene expression].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1994;114(6):357-73.
1994: Yuichi Hashimoto; Masako Togo; Kazuhisa Tsukamoto; Y Horie; T Watanabe; Kiyoshi Kurokawa
Protein kinase C-dependent and -independent mechanisms of dense granule exocytosis by human platelets.
Biochimica et biophysica acta 1994;1222(1):56-62.
1994: L Eyrolles; Hiroyuki Kagechika; Emiko Kawachi; Hiroshi Fukasawa; Toru Iijima; Y Matsushima; Yuichi Hashimoto; Koichi Shudo
Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring.
Journal of medicinal chemistry 1994;37(10):1508-17.
1994: K Nishimura; Yuichi Hashimoto; S Iwasaki
(S)-form of alpha-methyl-N(alpha)-phthalimidoglutarimide, but not its (R)-form, enhanced phorbol ester-induced tumor necrosis factor-alpha production by human leukemia cell HL-60: implication of optical resolution of thalidomidal effects.
Chemical & pharmaceutical bulletin 1994;42(5):1157-9.
1994: O Nakajima; Y Sugishita; Yuichi Hashimoto; S Iwasaki
Increase in the chemically-induced differentiation of human leukemia cell lines by tubulin disruptors.
Biological & pharmaceutical bulletin 1994;17(5):742-4.
1994: K Nishimura; Yuichi Hashimoto; S Iwasaki
Enhancement of phorbol ester-induced production of tumor necrosis factor alpha by thalidomide.
Biochemical and biophysical research communications 1994;199(2):455-60.
1994: Y Endo; Hiroshi Fukasawa; Yuichi Hashimoto; Koichi Shudo
Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters.
Chemical & pharmaceutical bulletin 1994;42(3):462-9.
1994: O Nakajima; Yuichi Hashimoto; S Iwasaki
Erythroid differentiation-inducing activity of protoporphyrin IX and its analogs on human leukemia K562 cell line.
Biochemical and biophysical research communications 1994;198(2):720-7.
1993: Yuichi Hashimoto; T Watanabe; M Kinoshita; Kazuhisa Tsukamoto; Masako Togo; Y Horie; Yoshihiro Matsuda; Kiyoshi Kurokawa
Ca2+ entry pathways activated by the tumor promoter thapsigargin in human platelets.
Biochimica et biophysica acta 1993;1220(1):37-41.
1993: T Nakayama; Yuichi Hashimoto; Y Kaneko; M Yoshida; T Beppu; Kazuhiro Ohmi; S Yamashita; Yoshinori Nonomura; Kiyoshi Kurokawa
K252a: a new blocker of the cell-cycle at G1 phase in a human hepatoma cell line.
Experientia 1993;49(10):876-80.
1993: Kazuhiro Ohmi; S Yamashita; Yuichi Hashimoto; Yoshinori Nonomura
Induction of giant endothelial cells in culture by K-252a, a protein kinase inhibitor.
Japanese journal of pharmacology 1993;63(2):195-202.
1993: O Nakajima; Yuichi Hashimoto; S Iwasaki
Enhancement by retinoid of hemin-induced differentiation of human leukemia K562 cell line.
FEBS letters 1993;330(1):81-4.
1993: Y Endo; Yuichi Hashimoto; Hiroshi Fukasawa; Koichi Shudo
Oxygenated cholesterols as ligands for cytosolic-nuclear tumor promoter binding protein: yakkasteroids.
Biochemical and biophysical research communications 1993;194(3):1529-35.
1993: T Sawada; Y Kato; H Kobayashi; Yuichi Hashimoto; T Watanabe; Y Sugiyama; S Iwasaki
A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin.
Bioconjugate chemistry 1993;4(4):284-9.
1993: Tetsuji Sawada; Hiroshi Kobayashi; Yuichi Hashimoto; S Iwasaki
Identification of the fragment photoaffinity-labeled with azidodansyl-rhizoxin as Met-363-Lys-379 on beta-tubulin.
Biochemical pharmacology 1993;45(7):1387-94.
1993: Hiroshi Fukasawa; Toru Iijima; Hiroyuki Kagechika; Yuichi Hashimoto; Koichi Shudo
Expression of the ligand-binding domain-containing region of retinoic acid receptors alpha, beta and gamma in Escherichia coli and evaluation of ligand-binding selectivity.
Biological & pharmaceutical bulletin 1993;16(4):343-8.
1993: R Nagata; Emiko Kawachi; Yuichi Hashimoto; Koichi Shudo
Cytokinin-specific binding protein in etiolated mung bean seedlings.
Biochemical and biophysical research communications 1993;191(2):543-9.
1993: O N Iwanami; Koichi Shudo; Yuichi Hashimoto
Meso-oligodeoxyribonucleotides.
Nucleic acids symposium series 1993;(29):15-6.
1992: Y Matsushima; Emiko Kawachi; H Tanaka; Hiroyuki Kagechika; Yuichi Hashimoto; Koichi Shudo
Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells.
Biochemical and biophysical research communications 1992;189(2):1136-42.
1992: Yuichi Hashimoto; S Hirohata; T Kashiwado; K Itoh; H Ishii
Cytokine regulation of hemostatic property and IL-6 production of human endothelial cells.
Inflammation 1992;16(6):613-21.
1992: Y Li; Hiroshi Kobayashi; Yuichi Hashimoto; S Iwasaki
Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins.
Biochemical and biophysical research communications 1992;187(2):722-9.
1992: Yuichi Hashimoto; A Ogihara; S Nakanishi; Yoshihiro Matsuda; Kiyoshi Kurokawa; Yoshinori Nonomura
Two thrombin-activated Ca2+ channels in human platelets.
The Journal of biological chemistry 1992;267(24):17078-81.
1992: Yuichi Hashimoto; Makoto Nishiyama; F Yu; I Watanabe; Sueharu Horinouchi; T Beppu
Development of a host-vector system in a Rhodococcus strain and its use for expression of the cloned nitrile hydratase gene cluster.
Journal of general microbiology 1992;138(5):1003-10.
1992: H Tanaka; Hiroyuki Kagechika; Emiko Kawachi; Hiroshi Fukasawa; Yuichi Hashimoto; Koichi Shudo
Base-catalyzed isomerization of retinoic acid. Synthesis and differentiation-inducing activities of 14-alkylated all-trans-, 13-cis-, and 20,14-retro-retinoic acids.
Journal of medicinal chemistry 1992;35(3):567-72.
1992: Y Li; Hiroshi Kobayashi; Y Tokiwa; Yuichi Hashimoto; S Iwasaki
Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site.
Biochemical pharmacology 1992;43(2):219-24.
1991: Yuichi Hashimoto; T Nakayama; Tamio Teramoto; H Kato; T Watanabe; Makoto Kinoshita; Kazuhisa Tsukamoto; K Tokunaga; Kiyoshi Kurokawa; S Nakanishi
Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926.
Biochemical and biophysical research communications 1991;181(1):423-9.
1991: R Shimazawa; S Hibino; Hideaki Mizoguchi; Yuichi Hashimoto; S Iwasaki; Hiroyuki Kagechika; Koichi Shudo
Fluorescent probes for retinoic acid receptors: molecular measures for the ligand binding pocket.
Biochemical and biophysical research communications 1991;180(1):249-54.
1991: Yuichi Hashimoto; Koichi Shudo
[Retinoids and acute promyelocytic leukemia].
Gan to kagaku ryoho. Cancer & chemotherapy 1991;18(13):2203-9.
1991: R Shimazawa; R Sanda; Hideaki Mizoguchi; Yuichi Hashimoto; S Iwasaki; H Tanaka; Hiroyuki Kagechika; Koichi Shudo
Fluorescent and photoaffinity labeling probes for retinoic acid receptors.
Biochemical and biophysical research communications 1991;179(1):259-65.
1991: Tetsuji Sawada; Yuichi Hashimoto; Y Li; Hiroshi Kobayashi; S Iwasaki
Fluorescent and photoaffinity labeling derivatives of rhizoxin.
Biochemical and biophysical research communications 1991;178(2):558-62.
1991: Yuichi Hashimoto; Koichi Shudo
Cytosolic-nuclear tumor promoter-specific binding protein: association with the 90 kDa heat shock protein and translocation into nuclei by treatment with 12-O-tetradecanoylphorbol 13-acetate.
Japanese journal of cancer research : Gann 1991;82(6):665-75.
1991: Yuichi Hashimoto
Retinobenzoic acids and nuclear retinoic acid receptors.
Cell structure and function 1991;16(2):113-23.
1991: Yuichi Hashimoto; Makoto Nishiyama; O Ikehata; Sueharu Horinouchi; T Beppu
Cloning and characterization of an amidase gene from Rhodococcus species N-774 and its expression in Escherichia coli.
Biochimica et biophysica acta 1991;1088(2):225-33.
1991: T Suzuki; Yuichi Hashimoto; Hiroyuki Okuno; H Sato; Hiroshi Nishina; Hideo Iba
High-level expression of human c-jun gene causes cellular transformation of chicken embryo fibroblasts.
Japanese journal of cancer research : Gann 1991;82(1):58-64.
1991: S Fujimori; N Iwanami; Koichi Shudo; Yuichi Hashimoto
Enantio- and meso-oligodeoxyribonucleotides.
Nucleic acids symposium series 1991;(25):143-4.
1991: Yuichi Hashimoto; Koichi Shudo
Retinoids and their nuclear receptors.
Cell biology reviews : CBR 1991;25(3):209-35.
1991: J Akimoto; K Ikeda; M Tomonaga; F Saito; T Miwa; A Awaya; Yuichi Hashimoto; H Fukui
[Mouse fetal brain specific protein "GP68" is expressed in human tumor cells].
Nō to shinkei = Brain and nerve 1991;43(1):25-9.
1991: Yuichi Hashimoto; Koichi Shudo
Retinoids and their nuclear receptors.
Cell biology reviews : CBR 1991;25(3):209-30, 233-5.
1990: T Yamakawa; Hiroyuki Kagechika; Emiko Kawachi; Yuichi Hashimoto; Koichi Shudo
Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60.
Journal of medicinal chemistry 1990;33(5):1430-7.
1990: Yuichi Hashimoto; Koichi Shudo
Cytosolic-nuclear tumor promoter-specific binding protein (CN-TPBP) in human promyelocytic leukemia cells HL-60.
Biochemical and biophysical research communications 1990;166(3):1126-32.
1990: Yuichi Hashimoto; Hiroyuki Kagechika; Koichi Shudo
Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR's).
Biochemical and biophysical research communications 1990;166(3):1300-7.
1990: S Fujimori; Koichi Shudo; Yuichi Hashimoto
Enantio-oligodeoxyribonucleotides.
Nucleic acids symposium series 1990;(22):97-8.
1990: S Kojima; A Awaya; M Ishido; Y Koyama; A Kubodera; Yuichi Hashimoto; H Fukui; H Muramatsu; Takashi Muramatsu
Radioimmunoimaging of tumors with radioactive antibody against a glycoprotein (GP68) found in developing mouse brain.
Journal of cancer research and clinical oncology 1990;116(4):336-40.
1989: Yuichi Hashimoto; K Chida; M Huang; M Katayama; T Nishihira; Toshio Kuroki
Levels of protein kinase C activity in human gastrointestinal cancers.
Biochemical and biophysical research communications 1989;163(1):406-11.
1989: Yuichi Hashimoto; Martin Petkovich; M P Gaub; Hiroyuki Kagechika; Koichi Shudo; Pierre Chambon
The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60.
Molecular endocrinology (Baltimore, Md.) 1989;3(7):1046-52.
1989: Hiroyuki Kagechika; T Himi; K Namikawa; Emiko Kawachi; Yuichi Hashimoto; Koichi Shudo
Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids.
Journal of medicinal chemistry 1989;32(5):1098-108.
1989: Hiroyuki Kagechika; Emiko Kawachi; Yuichi Hashimoto; Koichi Shudo
Retinobenzoic acids. 2. Structure-activity relationships of chalcone-4-carboxylic acids and flavone-4'-carboxylic acids.
Journal of medicinal chemistry 1989;32(4):834-40.
1989: Koichi Shudo; Yuichi Hashimoto
[DNA modification and carcinogenesis--early events caused by a heterocyclic aromatic amine, Glu-P-1].
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):445-50.
1988: Hiroyuki Kagechika; Emiko Kawachi; Yuichi Hashimoto; T Himi; Koichi Shudo
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Journal of medicinal chemistry 1988;31(11):2182-92.
1988: Hiroyuki Kagechika; Yuichi Hashimoto; Emiko Kawachi; Koichi Shudo
[Recent advances in retinoids studies].
Gan to kagaku ryoho. Cancer & chemotherapy 1988;15(10):2839-47.
1988: Hiroyuki Kagechika; Yuichi Hashimoto; Emiko Kawachi; Koichi Shudo
Affinity gels for purification of retinoid-specific binding protein (RSBP).
Biochemical and biophysical research communications 1988;155(1):503-8.
1988: Yuichi Hashimoto; Hiroyuki Kagechika; Emiko Kawachi; Koichi Shudo
Specific uptake of retinoids into human promyelocytic leukemia cells HL-60 by retinoid-specific binding protein: possibly the true retinoid receptor.
Japanese journal of cancer research : Gann 1988;79(4):473-83.