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Yuichi Hashimoto

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Co-Publications
Name
55
Miyachi, Hiroyuki
55
Shudo, Koichi
40
Iwasaki, S
37
Kagechika, Hiroyuki
27
Kawachi, Emiko
26
Fukasawa, Hiroshi
20
Nagasawa, Kazuo
17
Makishima, Makoto
17
Tanatani, Aya
14
Noguchi, Tomomi
14
Koiso, Yukiko
13
Kurokawa, Kiyoshi
12
Morisaki, Naoko
12
Shirai, Ryuichi
12
Togo, Masako

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Publications

TOP 3
Kasuga Jun-ichi; Ishida Seiichi; Yamasaki Daisuke; Makishima Makoto; Doi Takefumi; Hashimoto Yuichi; Miyachi Hiroyuki
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.
Motoshima Kazunori; Ishikawa Minoru; Sugita Kazuyuki; Hashimoto Yuichi
Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.
Hosoda Shinnosuke; Matsuda Daisuke; Tomoda Hiroshi; Hashimoto Mariko; Aoyama Hiroshi; Hashimoto Yuichi
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.

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All Publications

2009: Kasuga Jun-ichi; Ishida Seiichi; Yamasaki Daisuke; Makishima Makoto; Doi Takefumi; Hashimoto Yuichi; Miyachi Hiroyuki
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists.
Bioorganic & medicinal chemistry letters 2009;19(23):6595-9.
2009: Motoshima Kazunori; Ishikawa Minoru; Sugita Kazuyuki; Hashimoto Yuichi
Glycogen phosphorylase a inhibitors with a phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists.
Biological & pharmaceutical bulletin 2009;32(9):1618-20.
2009: Hosoda Shinnosuke; Matsuda Daisuke; Tomoda Hiroshi; Hashimoto Mariko; Aoyama Hiroshi; Hashimoto Yuichi
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4228-31.
2009: Motoshima Kazunori; Noguchi-Yachide Tomomi; Sugita Kazuyuki; Hashimoto Yuichi; Ishikawa Minoru
Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.
Bioorganic & medicinal chemistry 2009;17(14):5001-14.
2009: Nakamura Masahiko; Hamasaki Takayuki; Tokitou Maiko; Baba Masanori; Hashimoto Yuichi; Aoyama Hiroshi
Discovery of tetrahydrotetramethylnaphthalene analogs as adult T-cell leukemia cell-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis.
Bioorganic & medicinal chemistry 2009;17(13):4740-6.
2009: Wakabayashi Ken-ichi; Okamura Masashi; Tsutsumi Shuichi; Nishikawa Naoko S; Tanaka Toshiya; Sakakibara Iori; Kitakami Jun-ichi; Ihara Sigeo; Hashimoto Yuichi; Hamakubo Takao; Kodama Tatsuhiko; Aburatani Hiroyuki; Sakai Juro
The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.
Molecular and cellular biology 2009;29(13):3544-55.
2009: Kasuga Jun-Ichi; Oyama Takuji; Nakagome Izumi; Aoyama Atsushi; Sako Kumiko; Makishima Makoto; Hirono Shuichi; Morikawa Kosuke; Hashimoto Yuichi; Miyachi Hiroyuki
[Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(6):709-18.
2009: Hosoda Shinnosuke; Aoyama Hiroshi; Goto Yukinori; Salim Mohammed T A; Okamoto Mika; Hashimoto Mariko; Baba Masanori; Hashimoto Yuichi
Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.
Bioorganic & medicinal chemistry letters 2009;19(12):3157-61.
2009: Hosoda Shinnosuke; Matsuda Daisuke; Tomoda Hiroshi; Hashimoto Yuichi
Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.
Mini reviews in medicinal chemistry 2009;9(5):572-80.
2009: Noguchi-Yachide Tomomi; Tetsuhashi Masashi; Aoyama Hiroshi; Hashimoto Yuichi
Enhancement of chemically-induced HL-60 cell differentiation by 3,3'-diindolylmethane derivatives.
Chemical & pharmaceutical bulletin 2009;57(5):536-40.
2009: Dodo Kosuke; Minato Taro; Hashimoto Yuichi
Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate.
Chemical & pharmaceutical bulletin 2009;57(2):190-4.
2008: Kasuga Jun-Ichi; Oyama Takuji; Nakagome Izumi; Makishima Makoto; Hirono Shuichi; Morikawa Kosuke; Hashimoto Yuichi; Miyachi Hiroyuki
Determination of the critical amino acids involved in the peroxisome proliferator-activated receptor (PPAR) delta selectivity of phenylpropanoic acid-derived agonists.
ChemMedChem 2008;3(11):1662-6.
2008: Misawa Takashi; Aoyama Hiroshi; Furuyama Taniyuki; Dodo Kosuke; Sagawa Morihiko; Miyachi Hiroyuki; Kizaki Masahiro; Hashimoto Yuichi
Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis.
Chemical & pharmaceutical bulletin 2008;56(10):1490-5.
2008: Araya Yoko; Kasuga Jun-Ichi; Toyota Kenji; Hirakawa Yuko; Oyama Takuji; Makishima Makoto; Morikawa Kosuke; Hashimoto Yuichi; Miyachi Hiroyuki
Structure-based design and synthesis of fluorescent PPARalpha/delta co-agonist and its application as a probe for fluorescent polarization assay of PPARdelta ligands.
Chemical & pharmaceutical bulletin 2008;56(9):1357-9.
2008: Dodo Kosuke; Minato Taro; Noguchi-Yachide Tomomi; Suganuma Masami; Hashimoto Yuichi
Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.
Bioorganic & medicinal chemistry 2008;16(17):7975-82.
2008: Kasuga Jun-ichi; Oyama Takuji; Hirakawa Yuko; Makishima Makoto; Morikawa Kosuke; Hashimoto Yuichi; Miyachi Hiroyuki
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.
Bioorganic & medicinal chemistry letters 2008;18(16):4525-8.
2008: Nakagawa Aya; Uno Shigeyuki; Makishima Makoto; Miyachi Hiroyuki; Hashimoto Yuichi
Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton.
Bioorganic & medicinal chemistry 2008;16(14):7046-54.
2008: Wakabayashi Ken-ichi; Imai Keisuke; Miyachi Hiroyuki; Hashimoto Yuichi; Tanatani Aya
4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.
Bioorganic & medicinal chemistry 2008;16(14):6799-812.
2008: Sato Shinichi; Aoyama Hiroshi; Miyachi Hiroyuki; Naito Mikihiko; Hashimoto Yuichi
Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs.
Bioorganic & medicinal chemistry letters 2008;18(11):3354-8.
2008: Kobayashi Hisayoshi; Morisaki Naoko; Miyachi Hiroyuki; Hashimoto Yuichi
Coordination of divalent metal cation to amide group to form adduct ion in FAB mass spectrometry: implication of Zn2+ in enzymatic hydrolysis of amide bond.
Chemical & pharmaceutical bulletin 2008;56(5):672-6.
2008: Dodo Kosuke; Aoyama Atsushi; Noguchi-Yachide Tomomi; Makishima Makoto; Miyachi Hiroyuki; Hashimoto Yuichi
Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
Bioorganic & medicinal chemistry 2008;16(8):4272-85.
2008: Sato Shinichi; Tetsuhashi Masashi; Sekine Keiko; Miyachi Hiroyuki; Naito Mikihiko; Hashimoto Yuichi; Aoyama Hiroshi
Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.
Bioorganic & medicinal chemistry 2008;16(8):4685-98.
2008: Sako Kumiko; Aoyama Hiroshi; Sato Shinichi; Hashimoto Yuichi; Baba Masanori
Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
Bioorganic & medicinal chemistry 2008;16(7):3780-90.
2008: Fujimoto Haruka; Aoyama Hiroshi; Noguchi-Yachide Tomomi; Hashimoto Yuichi; Kobayashi Hisayoshi
Fusarielin A as an anti-angiogenic and anti-proliferative agent: basic biological characterization.
Chemical & pharmaceutical bulletin 2008;56(3):298-304.
2008: Kasuga Jun-ichi; Yamasaki Daisuke; Ogura Kiyoshi; Shimizu Motomu; Sato Mayumi; Makishima Makoto; Doi Takefumi; Hashimoto Yuichi; Miyachi Hiroyuki
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.
Bioorganic & medicinal chemistry letters 2008;18(3):1110-5.
2008: Miyachi Hiroyuki; Hashimoto Yuichi
Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template.
PPAR research 2008;2008():689859.
2007: Noguchi-Yachide Tomomi; Miyachi Hiroyuki; Aoyama Hiroshi; Aoyama Atsushi; Makishima Makoto; Hashimoto Yuichi
Structural development of liver X receptor (LXR) antagonists derived from thalidomide-related glucosidase inhibitors.
Chemical & pharmaceutical bulletin 2007;55(12):1750-4.
2007: Hosoda Shinnosuke; Hashimoto Yuichi
3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.
Bioorganic & medicinal chemistry letters 2007;17(19):5414-8.
2007: Lee Shoukou; Shinji Chihiro; Ogura Kiyoshi; Shimizu Motomu; Maeda Satoko; Sato Mayumi; Yoshida Minoru; Hashimoto Yuichi; Miyachi Hiroyuki
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(17):4895-900.
2007: Kasuga Jun-Ichi; Nakagome Izumi; Aoyama Atsushi; Sako Kumiko; Ishizawa Michiyasu; Ogura Michitaka; Makishima Makoto; Hirono Shuichi; Hashimoto Yuichi; Miyachi Hiroyuki
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Bioorganic & medicinal chemistry 2007;15(15):5177-90.
2007: Noguchi-Yachide Tomomi; Aoyama Atsushi; Makishima Makoto; Miyachi Hiroyuki; Hashimoto Yuichi
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(14):3957-61.
2007: Aoyama Hiroshi; Noguchi Tomomi; Misawa Takashi; Nakamura Takanori; Miyachi Hiroyuki; Hashimoto Yuichi; Kobayashi Hisayoshi
Development of tubulin-polymerization inhibitors based on the thalidomide skeleton.
Chemical & pharmaceutical bulletin 2007;55(6):944-9.
2007: Nakamura Takanori; Noguchi Tomomi; Miyachi Hiroyuki; Hashimoto Yuichi
Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.
Chemical & pharmaceutical bulletin 2007;55(4):651-4.
2007: Kainuma Masahiko; Makishima Makoto; Hashimoto Yuichi; Miyachi Hiroyuki
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
Bioorganic & medicinal chemistry 2007;15(7):2587-600.
2007: Uchiyama Masanobu; Matsumoto Yotaro; Usui Shinya; Hashimoto Yuichi; Morokuma Keiji
Origin of chemoselectivity of TMP zincate bases and differences between TMP zincate and alkyl lithium reagents: a DFT study on model systems.
Angewandte Chemie (International ed. in English) 2007;46(6):926-9.
2006: Nakamura Takanori; Noguchi Tomomi; Kobayashi Hisayoshi; Miyachi Hiroyuki; Hashimoto Yuichi
Mono- and dihydroxylated metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.
Chemical & pharmaceutical bulletin 2006;54(12):1709-14.
2006: Kasuga Jun-ichi; Yamasaki Daisuke; Araya Yoko; Nakagawa Aya; Makishima Makoto; Doi Takefumi; Hashimoto Yuichi; Miyachi Hiroyuki
Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome.
Bioorganic & medicinal chemistry 2006;14(24):8405-14.
2006: Shinji Chihiro; Maeda Satoko; Imai Keisuke; Yoshida Minoru; Hashimoto Yuichi; Miyachi Hiroyuki
Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors.
Bioorganic & medicinal chemistry 2006;14(22):7625-51.
2006: Yanagawa Tomonori; Noguchi Tomomi; Miyachi Hiroyuki; Kobayashi Hisayoshi; Hashimoto Yuichi
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
Bioorganic & medicinal chemistry letters 2006;16(18):4748-51.
2006: Hosoda Shinnosuke; Tanatani Aya; Wakabayashi Ken-Ichi; Makishima Makoto; Imai Keisuke; Miyachi Hiroyuki; Nagasawa Kazuo; Hashimoto Yuichi
Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation.
Bioorganic & medicinal chemistry 2006;14(16):5489-502.
2006: Fujimoto Haruka; Noguchi Tomomi; Kobayashi Hisayoshi; Miyachi Hiroyuki; Hashimoto Yuichi
Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.
Chemical & pharmaceutical bulletin 2006;54(6):855-60.
2006: Kainuma Masahiko; Kasuga Jun-ichi; Hosoda Shinnosuke; Wakabayashi Ken-ichi; Tanatani Aya; Nagasawa Kazuo; Miyachi Hiroyuki; Makishima Makoto; Hashimoto Yuichi
Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
Bioorganic & medicinal chemistry letters 2006;16(12):3213-8.
2006: Sano Hiroko; Noguchi Tomomi; Miyajima Atsushi; Hashimoto Yuichi; Miyachi Hiroyuki
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):3068-72.
2006: Nakano Yusuke; Kato Yuko; Imai Keisuke; Ochiai Eiji; Namekawa Jun-Ichi; Ishizuka Seiichi; Takenouchi Kazuya; Tanatani Aya; Hashimoto Yuichi; Nagasawa Kazuo
Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.
Journal of medicinal chemistry 2006;49(8):2398-406.
2006: Kasuga Jun-ichi; Hashimoto Yuichi; Miyachi Hiroyuki
Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: dual agonists for human peroxisome proliferator-activated receptor alpha and delta.
Bioorganic & medicinal chemistry letters 2006;16(4):771-4.
2006: Kasuga Jun-ichi; Makishima Makoto; Hashimoto Yuichi; Miyachi Hiroyuki
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.
Bioorganic & medicinal chemistry letters 2006;16(3):554-8.
2005: Noguchi Tomomi; Fujimoto Haruka; Sano Hiroko; Miyajima Atsushi; Miyachi Hiroyuki; Hashimoto Yuichi
Angiogenesis inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(24):5509-13.
2005: Shimokawa Jun; Ishiwata Takanori; Shirai Koji; Koshino Hiroyuki; Tanatani Aya; Nakata Tadashi; Hashimoto Yuichi; Nagasawa Kazuo
Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and identification of their target protein.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(23):6878-88.
2005: Shinji Chihiro; Nakamura Takanori; Maeda Satoko; Yoshida Minoru; Hashimoto Yuichi; Miyachi Hiroyuki
Design and synthesis of phthalimide-type histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(20):4427-31.
2005: Hosoda Shinnosuke; Tanatani Aya; Wakabayashi Ken-ichi; Nakano Yusuke; Miyachi Hiroyuki; Nagasawa Kazuo; Hashimoto Yuichi
Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities.
Bioorganic & medicinal chemistry letters 2005;15(19):4327-31.
2005: Hashimoto Yuichi; Miyachi Hiroyuki
Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.
Bioorganic & medicinal chemistry 2005;13(17):5080-93.
2005: Noguchi Tomomi; Miyachi Hiroyuki; Katayama Ryohei; Naito Mikihiko; Hashimoto Yuichi
Cell differentiation inducers derived from thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(13):3212-5.
2005: Sano Hiroko; Noguchi Tomomi; Tanatani Aya; Hashimoto Yuichi; Miyachi Hiroyuki
Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry 2005;13(9):3079-91.
2005: Wakabayashi Ken-ichi; Miyachi Hiroyuki; Hashimoto Yuichi; Tanatani Aya
Novel non-steroidal/non-anilide type androgen antagonists: discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands.
Bioorganic & medicinal chemistry 2005;13(8):2837-46.
2005: Noguchi Tomomi; Shinji Chihiro; Kobayashi Hisayoshi; Makishima Makoto; Miyachi Hiroyuki; Hashimoto Yuichi
Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.
Biological & pharmaceutical bulletin 2005;28(3):563-4.
2005: Inatsuki Shunsuke; Noguchi Tomomi; Miyachi Hiroyuki; Oda Sawako; Iguchi Toyotaka; Kizaki Masahiro; Hashimoto Yuichi; Kobayashi Hisayoshi
Tubulin-polymerization inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry letters 2005;15(2):321-5.
2004: Sano Hiroko; Noguchi Tomomi; Tanatani Aya; Miyachi Hiroyuki; Hashimoto Yuichi
N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: substituent effects on subtype selectivity.
Chemical & pharmaceutical bulletin 2004;52(8):1021-2.
2004: Noguchi Tomomi; Sano Hiroko; Shimazawa Rumiko; Tanatani Aya; Miyachi Hiroyuki; Hashimoto Yuichi
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide.
Bioorganic & medicinal chemistry letters 2004;14(16):4141-5.
2004: Baba Yoshiyasu; Mayumi Satoshi; Hirai Go; Kawasaki Hidekazu; Ogoshi Yosuke; Yanagisawa Takeshi; Hashimoto Yuichi; Sodeoka Mikiko
Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.
Bioorganic & medicinal chemistry letters 2004;14(11):2969-72.
2004: Baba Yoshiyasu; Ogoshi Yosuke; Hirai Go; Yanagisawa Takeshi; Nagamatsu Kumiko; Mayumi Satoshi; Hashimoto Yuichi; Sodeoka Mikiko
Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.
Bioorganic & medicinal chemistry letters 2004;14(11):2963-7.
2004: Kato Yuko; Nakano Yusuke; Sano Hiroko; Tanatani Aya; Kobayashi Hisayoshi; Shimazawa Rumiko; Koshino Hiroyuki; Hashimoto Yuichi; Nagasawa Kazuo
Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist.
Bioorganic & medicinal chemistry letters 2004;14(10):2579-83.
2004: Shimazawa Rumiko; Sano Hiroko; Tanatani Aya; Miyachi Hiroyuki; Hashimoto Yuichi
Thalidomide as a nitric oxide synthase inhibitor and its structural development.
Chemical & pharmaceutical bulletin 2004;52(4):498-9.
2004: Sohtome Yoshihiro; Tanatani Aya; Hashimoto Yuichi; Nagasawa Kazuo
Development of novel chiral urea catalysts for the hetero-Michael reaction.
Chemical & pharmaceutical bulletin 2004;52(4):477-80.
2004: Hashimoto Yuichi; Matsuda Takahiko; Matsuura Yoshiharu; Haga Tatsuya; Fukada Yoshitaka
Production of N-lauroylated G protein alpha-subunit in Sf9 insect cells: the type of N-acyl group of Galpha influences G protein-mediated signal transduction.
Journal of biochemistry 2004;135(3):319-29.
2004: Shimokawa Jun; Shirai Koji; Tanatani Aya; Hashimoto Yuichi; Nagasawa Kazuo
Enantioselective total synthesis of batzelladine A.
Angewandte Chemie (International ed. in English) 2004;43(12):1559-62.
2003: Morisaki Naoko; Kobayashi Hisayoshi; Nagasawa Kazuo; Baba Yoshiyasu; Sodeoka Mikiko; Hashimoto Yuichi
Conversion of Ca2+ salt of an organic compound to its Li+ salt to simplify the fast atom bombardment mass spectrum.
Chemical & pharmaceutical bulletin 2003;51(11):1341-4.
2003: Kakuta Hiroki; Tanatani Aya; Nagasawa Kazuo; Hashimoto Yuichi
Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.
Chemical & pharmaceutical bulletin 2003;51(11):1273-82.
2003: Suizu Mamiko; Muroya Yohei; Kakuta Hiroki; Kagechika Hiroyuki; Tanatani Aya; Nagasawa Kazuo; Hashimoto Yuichi
Cyclooxygenase inhibitors derived from thalidomide.
Chemical & pharmaceutical bulletin 2003;51(9):1098-102.
2003: Ishioka Toshiyasu; Tanatani Aya; Nagasawa Kazuo; Hashimoto Yuichi
Anti-androgens with full antagonistic activity toward human prostate tumor LNCaP cells with mutated androgen receptor.
Bioorganic & medicinal chemistry letters 2003;13(16):2655-8.
2003: Hashimoto Yuichi
Structural development of synthetic retinoids and thalidomide-related molecules.
Cancer chemotherapy and pharmacology 2003;52 Suppl 1():S16-23.
2003: Kakuta Hiroki; Koiso Yukiko; Nagasawa Kazuo; Hashimoto Yuichi
Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells.
Bioorganic & medicinal chemistry letters 2003;13(1):83-6.
2003: Nagasawa Kazuo; Hashimoto Yuichi
Synthesis of marine guanidine alkaloids and their application as chemical/biological tools.
Chemical record (New York, N.Y.) 2003;3(4):201-11.
2002: Hashimoto Yuichi
Structural development of biological response modifiers based on retinoids and thalidomide.
Mini reviews in medicinal chemistry 2002;2(6):543-51.
2002: Kita Tetsuya; Georgieva Angelina; Hashimoto Yuichi; Nakata Tadashi; Nagasawa Kazuo
C(2)-symmetric chiral pentacyclic guanidine: a phase-transfer catalyst for the asymmetric alkylation of tert-butyl glycinate Schiff base.
Angewandte Chemie (International ed. in English) 2002;41(15):2832-4.
2002: Ishiwata Takanori; Hino Tomoyuki; Koshino Hiroyuki; Hashimoto Yuichi; Nakata Tadashi; Nagasawa Kazuo
Total synthesis of batzelladine D.
Organic letters 2002;4(17):2921-4.
2002: Takahashi Bitoku; Ohta Kiminori; Kawachi Emiko; Fukasawa Hiroshi; Hashimoto Yuichi; Kagechika Hiroyuki
Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions.
Journal of medicinal chemistry 2002;45(16):3327-30.
2002: Morisaki Naoko; Kobayashi Hisayoshi; Yamamura Yumiko; Morisaki Masuo; Nagasawa Kazuo; Hashimoto Yuichi
Coordination of sodium cation to an oxygen function and olefinic double bond to form molecular adduct ion in fast atom bombardment mass spectrometry.
Chemical & pharmaceutical bulletin 2002;50(7):935-40.
2002: Ishioka Toshiyasu; Kubo Asako; Koiso Yukiko; Nagasawa Kazuo; Itai Akiko; Hashimoto Yuichi
Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety.
Bioorganic & medicinal chemistry 2002;10(5):1555-66.
2002: Noguchi Tomomi; Shimazawa Rumiko; Nagasawa Kazuo; Hashimoto Yuichi
Thalidomide and its analogues as cyclooxygenase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(7):1043-6.
2002: Hashimoto Yuichi
Structural development of biological response modifiers based on thalidomide.
Bioorganic & medicinal chemistry 2002;10(3):461-79.
2002: Nagasawa Kazuo; Georgieva Angelina; Koshino Hiroyuki; Nakata Tadashi; Kita Tetsuya; Hashimoto Yuichi
Total synthesis of crambescidin 359.
Organic letters 2002;4(2):177-80.
2001: Noto H; Hashimoto Y; Satoh H; Hara M; Iso-o N; Togo M; Kimura S; Tsukamoto K
Exclusive association of paraoxonase 1 with high-density lipoprotein particles in apolipoprotein A-I deficiency.
Biochemical and biophysical research communications 2001;289(2):395-401.
2001: Hashimoto Y; Futamura A; Nakarai H; Nakahara K
Relationship between response of gamma-glutamyl transpeptidase to alcohol drinking and risk factors for coronary heart disease.
Atherosclerosis 2001;158(2):465-70.
2001: Saito R; Hashimoto Y; Futamura A; Watanabe N; Mashige F; Nakarai H; Nakahara K
[Reference intervals of urinary biochemical analysis in Japanese men]
Rinsho byori. The Japanese journal of clinical pathology 2001;49(7):707-10.
2001: Kita T; Takahashi H; Hashimoto Y
Thymidine phosphorylase inhibitors with a homophthalimide skeleton.
Biological & pharmaceutical bulletin 2001;24(7):860-2.
2001: Sou S; Takahashi H; Yamasaki R; Kagechika H; Endo Y; Hashimoto Y
Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.
Chemical & pharmaceutical bulletin 2001;49(6):791-3.
2001: Ebisawa M; Ohta K; Kawachi E; Fukasawa H; Hashimoto Y; Kagechika H
Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure.
Chemical & pharmaceutical bulletin 2001;49(4):501-3.
2001: Takahashi H; Hashimoto Y
Formaldehyde-mediated modification of natural deoxyguanosine with amines: one-pot cyclization as a molecular model for genotoxicity.
Bioorganic & medicinal chemistry letters 2001;11(5):729-31.
2001: Morisaki N; Hashimoto Y; Furihata K; Yazawa K; Tamura M; Mikami Y
Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain.
The Journal of antibiotics 2001;54(2):157-65.
2001: Togo M; Toda T; Nguyen L A; Kubota S; Tsukamoto K; Satoh H; Hara M; Iso-o N; Noto H; Kimura S; Nakahara K; Seyama Y; Hashimoto Y
Genetic analysis of phytosterolaemia.
Journal of inherited metabolic disease 2001;24(1):43-50.
2001: Sodeoka M; Sampe R; Kojima S; Baba Y; Morisaki N; Hashimoto Y
Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography.
Chemical & pharmaceutical bulletin 2001;49(2):206-12.
2001: Komoda M; Kakuta H; Takahashi H; Fujimoto Y; Kadoya S; Kato F; Hashimoto Y
Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study.
Bioorganic & medicinal chemistry 2001;9(1):121-31.
2001: Hashimoto Y; Futamura A; Nakarai H; Nakahara K
Effects of the frequency of alcohol intake on risk factors for coronary heart disease.
European journal of epidemiology 2001;17(4):307-12.
2000: Hara K; Kudoh H; Enomoto T; Hashimoto Y; Masuko T
Enhanced tumorigenicity caused by truncation of the extracellular domain of GP125/CD98 heavy chain.
Oncogene 2000;19(54):6209-15.
2000: Fukasawa H; Yamaguchi M; Hashimoto Y; Endo Y; Shudo K
Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription.
Biological & pharmaceutical bulletin 2000;23(12):1414-7.
2000: Takahashi M; Dodo K; Sugimoto Y; Aoyagi Y; Yamada Y; Hashimoto Y; Shirai R
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
Bioorganic & medicinal chemistry letters 2000;10(22):2571-4.
2000: Takahashi H; Ishioka T; Koiso Y; Sodeoka M; Hashimoto Y
Anti-androgenic activity of substituted azo- and azoxy-benzene derivatives.
Biological & pharmaceutical bulletin 2000;23(11):1387-90.
2000: Takahashi H; Komoda M; Kakuta H; Hashimoto Y
[Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2000;120(10):909-21.
2000: Ohta K; Kawachi E; Inoue N; Fukasawa H; Hashimoto Y; Itai A; Kagechika H
Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids.
Chemical & pharmaceutical bulletin 2000;48(10):1504-13.
2000: Takahashi H; Sou S; Yamasaki R; Sodeoka M; Hashimoto Y
Alpha-glucosidase inhibitors with a phthalimide skeleton: structure-activity relationship study.
Chemical & pharmaceutical bulletin 2000;48(10):1494-9.
2000: Watanabe N; Hashimoto Y; Okamoto K; Mashige F; Nakahara K
[Glioblastoma with a marked elevation of total protein and albumin in the cerebrospinal fluid]
Rinsho byori. The Japanese journal of clinical pathology 2000;48(9):877-9.
2000: Mayumi S; Azuma A; Kobayashi H; Sodeoka M; Yano K; Sugimoto S; Endo Y; Hashimoto Y
Identification of protein disulfide isomerase as a phorbol ester-binding protein.
Biological & pharmaceutical bulletin 2000;23(9):1111-3.
2000: Morisaki N; Masaoka M; Shirai R; Hashimoto Y
Separation of phosphatidylinositol 4-phosphate from a mixture with phosphatidylserine and phosphatidylinositol by Sep-Pak C18 cartridge.
Biological & pharmaceutical bulletin 2000;23(9):1088-9.
2000: Shishido T; Uno S; Kamohara M; Tsuneoka-Suzuki T; Hashimoto Y; Enomoto T; Masuko T
Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity.
International journal of cancer. Journal international du cancer 2000;87(3):311-6.
2000: Sou S; Mayumi S; Takahashi H; Yamasaki R; Kadoya S; Sodeoka M; Hashimoto Y
Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.
Bioorganic & medicinal chemistry letters 2000;10(10):1081-4.
2000: Tsuji M; Koiso Y; Takahashi H; Hashimoto Y; Endo Y
Modulators of tumor necrosis factor alpha production bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.
Biological & pharmaceutical bulletin 2000;23(4):513-6.
2000: Dodo K; Takahashi M; Yamada Y; Sugimoto Y; Hashimoto Y; Shirai R
Synthesis of a novel class of cdc25A inhibitors from vitamin D3.
Bioorganic & medicinal chemistry letters 2000;10(7):615-7.
2000: Matsumoto T; Yokote K; Take A; Takemoto M; Asaumi S; Hashimoto Y; Matsuda M; Saito Y; Mori S
Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.
Biochemical and biophysical research communications 2000;270(1):28-33.
2000: Morisaki N; Hashimoto Y; Furihata K; Imai T; Watanabe K; Mikami Y; Yazawa K; Ando A; Nagata Y; Dabbs E R
Structures of ADP-ribosylated rifampicin and its metabolite: intermediates of rifampicin-ribosylation by Mycobacterium smegmatis DSM43756.
The Journal of antibiotics 2000;53(3):269-75.
2000: Shishido T; Ohkawa M; Itoh A; Enomoto T; Hashimoto Y; Masuko T
Colocalization of GP125/CD98 with tropomyosin isoforms at the cell-cell adhesion boundary.
Journal of biochemistry 2000;127(2):253-61.
2000: Koiso Y; Nakajima O; Matsumura D; Fujimoto Y; Hashimoto Y
[Chemical control of cell differentiation of human myeloleukemia K562 cell line]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2000;120(1):104-12.
2000: Togo M; Hashimoto Y; Futamura A; Tsukamoto K; Satoh H; Hara M; Watanabe T; Nakarai H; Nakahara K; Kimura S
Relationship between the serum level of leptin and life-style habits in Japanese men.
Hormone research 2000;54(4):169-73.
2000: Minagawa M; Yasuda T; Someya T; Kohno Y; Saeki N; Hashimoto Y
Effects of octreotide infusion, surgery and estrogen on suppression of height increase and 20K growth hormone ratio in a girl with gigantism due to a growth hormone-secreting macroadenoma.
Hormone research 2000;53(3):157-60.
1999: Ebisawa M; Umemiya H; Ohta K; Fukasawa H; Kawachi E; Christoffel G; Gronemeyer H; Tsuji M; Hashimoto Y; Shudo K; Kagechika H
Retinoid X receptor-antagonistic diazepinylbenzoic acids.
Chemical & pharmaceutical bulletin 1999;47(12):1778-86.
1999: Kagechika H; Komoda M; Fujimoto Y; Koiso Y; Takayama H; Kadoya S; Miyata K; Kato F; Kato M; Hashimoto Y
Potent homophthalimide-type inhibitors of B16F10/L5 mouse melanoma cell invasion.
Biological & pharmaceutical bulletin 1999;22(9):1010-2.
1999: Hara K; Kudoh H; Enomoto T; Hashimoto Y; Masuko T
Malignant transformation of NIH3T3 cells by overexpression of early lymphocyte activation antigen CD98.
Biochemical and biophysical research communications 1999;262(3):720-5.
1999: Matsumoto Y; Satoh-Ueno K; Yoshimura A; Hashimoto Y; Enomoto T; Masuko T
Identification and immunological characterization of a novel 40-kDa protein linked to CD98 antigen.
Cell structure and function 1999;24(4):217-26.
1999: Fujimoto Y; Nagata R; Kobayashi H; Shudo K; Hashimoto Y
[Molecular identification of cytokinin-specific binding protein]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1999;119(8):612-23.
1999: Futamura A; Hashimoto Y; Okubo S; Aihara T; Watanabe H; Fujita A; Koda M; Nakahara K
[Urine C-peptide excretion in hypocaloric states and factors affecting its excretion]
Rinsho byori. The Japanese journal of clinical pathology 1999;47(6):566-70.
1999: Okubo S; Hashimoto Y; Futamura A; Watanabe N; Mashige H; Fujita A; Koda M; Nakahara K
[Effects of a 5-day fast on clinical laboratory data from patients with rheumatoid arthritis]
Rinsho byori. The Japanese journal of clinical pathology 1999;47(6):561-5.
1999: Koiso Y; Fujimoto Y; Matsumura D; Nakajima O; Hashimoto Y
Modification by heme oxygenase inhibitor, tin protoporphyrin, of cellular differentiation of human myeloid leukemia K562 cell line.
Biological & pharmaceutical bulletin 1999;22(4):439-40.
1999: Okubo S; Hashimoto Y; Futamura A; Morita K; Mashige H; Nakarai H; Nakahara K
[Comparison of LDL-C values measured with the automated method and the ultracentrifugation method in severe hypertriglyceridemia, and prevalence and life-style of patients with hypertriglyceridemia]
Rinsho byori. The Japanese journal of clinical pathology 1999;47(3):275-80.
1999: Watanabe N; Hashimoto Y; Futamura A; Mashige F; Nakarai H; Nakahara K
[Relationship between the prevalence of proteinuria and obesity in Japanese men]
Rinsho byori. The Japanese journal of clinical pathology 1999;47(3):271-4.
1999: Shimazawa R; Takayama H; Kato F; Kato M; Hashimoto Y
Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.
Bioorganic & medicinal chemistry letters 1999;9(4):559-62.
1999: Shimazawa R; Miyachi H; Takayama H; Kuroda K; Kato F; Kato M; Hashimoto Y
Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide.
Biological & pharmaceutical bulletin 1999;22(2):224-6.
1999: Hashimoto Y; Futamura A; Watanabe N; Togo M; Sato H; Hara M; Tsukamoto K; Kimura S; Nakahara K
Relationship between glycosylated hemoglobin and the prevalence of proteinuria in Japanese men.
Internal medicine (Tokyo, Japan) 1999;38(1):6-11.
1999: Satoh H; Tsukamoto K; Hashimoto Y; Hashimoto N; Togo M; Hara M; Maekawa H; Isoo N; Kimura S; Watanabe T
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.
Biochemical and biophysical research communications 1999;254(3):757-63.
1999: Quan S; Imai T; Mikami Y; Yazawa K; Dabbs E R; Morisaki N; Iwasaki S; Hashimoto Y; Furihata K
ADP-ribosylation as an intermediate step in inactivation of rifampin by a mycobacterial gene.
Antimicrobial agents and chemotherapy 1999;43(1):181-4.
1999: Imai T; Watanabe K; Mikami Y; Yazawa K; Ando A; Nagata Y; Morisaki N; Hashimoto Y; Furihata K; Dabbs E R
Identification and characterization of a new intermediate in the ribosylative inactivation pathway of rifampin by Mycobacterium smegmatis.
Microbial drug resistance (Larchmont, N.Y.) 1999;5(4):259-64.
1999: Shimazawa R; Takayama H; Fujimoto Y; Komoda M; Dodo K; Yamasaki R; Shirai R; Koiso Y; Miyata K; Kato F; Kato M; Miyachi H; Hashimoto Y
Novel small molecule nonpeptide aminopeptidase n inhibitors with a cyclic imide skeleton.
Journal of enzyme inhibition 1999;14(4):259-75.
1998: Fujimoto Y; Nagata R; Fukasawa H; Yano K; Azuma M; Iida A; Sugimoto S; Shudo K; Hashimoto Y
Purification and cDNA cloning of cytokinin-specific binding protein from mung bean (Vigna radiata).
European journal of biochemistry / FEBS 1998;258(2):794-802.
1998: Shirai R; Takayama H; Nishikawa A; Koiso Y; Hashimoto Y
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
Bioorganic & medicinal chemistry letters 1998;8(15):1997-2000.
1998: Miyachi H; Koiso Y; Shirai R; Niwayama S; Liu J O; Hashimoto Y
Tumor necrosis factor-alpha production enhancing activity of substituted 3'-methylthalidomide: influence of substituents at the phthaloyl moiety on the activity and stereoselectivity.
Chemical & pharmaceutical bulletin 1998;46(7):1165-8.
1998: Hangaishi M; Taguchi J; Miyata T; Ikari Y; Togo M; Hashimoto Y; Watanabe T; Kimura S; Kurokawa K; Ohno M
Increased aggregation of human platelets produced by advanced glycation end products in vitro.
Biochemical and biophysical research communications 1998;248(2):285-92.
1998: Matsuda T; Hashimoto Y; Ueda H; Asano T; Matsuura Y; Doi T; Takao T; Shimonishi Y; Fukada Y
Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.
Biochemistry 1998;37(27):9843-50.
1998: Hashimoto Y
Novel biological response modifiers derived from thalidomide.
Current medicinal chemistry 1998;5(3):163-78.
1998: Niwayama S; Loh C; Turk B E; Liu J O; Miyachi H; Hashimoto Y
Enhanced potency of perfluorinated thalidomide derivatives for inhibition of LPS-induced tumor necrosis factor-alpha production is associated with a change of mechanism of action.
Bioorganic & medicinal chemistry letters 1998;8(9):1071-6.
1998: Ebisawa M; Kawachi E; Fukasawa H; Hashimoto Y; Itai A; Shudo K; Kagechika H
Novel thiazolidinedione derivatives with retinoid synergistic activity.
Biological & pharmaceutical bulletin 1998;21(5):547-9.
1998: Ohta K; Tsuji M; Kawachi E; Fukasawa H; Hashimoto Y; Shudo K; Kagechika H
Potent retinoid synergists with a diphenylamine skeleton.
Biological & pharmaceutical bulletin 1998;21(5):544-6.
1998: Morisaki N; Mitsui Y; Yamashita Y; Koiso Y; Shirai R; Hashimoto Y; Iwasaki S
Synthesis and anti-tubulin activity of ustiloxin D derivatives.
The Journal of antibiotics 1998;51(4):423-7.
1998: Koiso Y; Morisaki N; Yamashita Y; Mitsui Y; Shirai R; Hashimoto Y; Iwasaki S
Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous peptide, ustiloxin B.
The Journal of antibiotics 1998;51(4):418-22.
1998: Shirai T; Tanaka K; Terada Y; Sawada T; Shirai R; Hashimoto Y; Nagata S; Iwamatsu A; Okawa K; Li S; Hattori S; Mano H; Fukui Y
Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins.
Biochimica et biophysica acta 1998;1402(3):292-302.
1998: Shirai R; Ito T; Iwasaki S; Hashimoto Y
Sequence selective interaction between nucleotides and intercalators bound to water soluble dextran: an application to the affinity chromatography of dinucleotides.
Nucleosides & nucleotides 1998;17(1-3):593-601.
1998: Miyachi H; Kato M; Kato F; Hashimoto Y
Novel potent nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton.
Journal of medicinal chemistry 1998;41(3):263-5.
1998: Hashimoto Y; Sasaki T
Photoaffinity labeling of RARs and mapping of labeled sites by an endoproteinase combination technique.
Methods in molecular biology (Clifton, N.J.) 1998;89():293-305.
1997: Umemiya H; Fukasawa H; Ebisawa M; Eyrolles L; Kawachi E; Eisenmann G; Gronemeyer H; Hashimoto Y; Shudo K; Kagechika H
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Journal of medicinal chemistry 1997;40(26):4222-34.
1997: Miyachi H; Ogasawara A; Azuma A; Hashimoto Y
Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study.
Bioorganic & medicinal chemistry 1997;5(11):2095-102.
1997: Tashima T; Kagechika H; Tsuji M; Fukasawa H; Kawachi E; Hashimoto Y; Shudo K
Polyenylidene thiazolidinedione derivatives with retinoidal activities.
Chemical & pharmaceutical bulletin 1997;45(11):1805-13.
1997: Satoh H; Togo M; Hara M; Miyata T; Han K; Maekawa H; Ohno M; Hashimoto Y; Kurokawa K; Watanabe T
Advanced glycation endproducts stimulate mitogen-activated protein kinase and proliferation in rabbit vascular smooth muscle cells.
Biochemical and biophysical research communications 1997;239(1):111-5.
1997: Hashimoto Y; Togo M; Sato H; Hashimoto N; Watanabe T; Kurokawa K; Nakahara K
Characteristics of protein kinase C-independent exocytosis in human platelets.
Thrombosis research 1997;88(1):51-8.
1997: Sasaki T; Morisaki N; Iwasaki S; Kagechika H; Fukasawa H; Shudo K; Shida Y; Hashimoto Y
Photoaffinity labeling of the ligand-interacting helix of the retinoic acid receptor alpha.
Biological & pharmaceutical bulletin 1997;20(8):913-6.
1997: Miyachi H; Azuma A; Ogasawara A; Uchimura E; Watanabe N; Kobayashi Y; Kato F; Kato M; Hashimoto Y
Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity.
Journal of medicinal chemistry 1997;40(18):2858-65.
1997: Kubo M; Ransom J; Webb D; Hashimoto Y; Tada T; Nakayama T
T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6.
The EMBO journal 1997;16(13):4007-20.
1997: Tanaka K; Imajoh-Ohmi S; Sawada T; Shirai R; Hashimoto Y; Iwasaki S; Kaibuchi K; Kanaho Y; Shirai T; Terada Y; Kimura K; Nagata S; Fukui Y
A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains.
European journal of biochemistry / FEBS 1997;245(2):512-9.
1997: Umemiya H; Kagechika H; Fukasawa H; Kawachi E; Ebisawa M; Hashimoto Y; Eisenmann G; Erb C; Pornon A; Chambon P; Gronemeyer H; Shudo K
Action mechanism of retinoid-synergistic dibenzodiazepines.
Biochemical and biophysical research communications 1997;233(1):121-5.
1997: Kobayashi H; Morisaki N; Tago Y; Hashimoto Y; Iwasaki S; Kawachi E; Nagata R; Shudo K
Structural identification of a major cytokinin in coconut milk as 14-O-(3-O-[beta-D-galactopyranosyl-(1-->2)-alpha-D-galactopyranosyl- (1-->3)-alpha-L-arabinofuranosyl]-4-O-(alpha-L-arabinofuranosyl)- beta-d-galactopyranosyl)-trans-zeatin riboside.
Chemical & pharmaceutical bulletin 1997;45(2):260-4.
1997: Miyachi H; Azuma A; Hashimoto Y
[Novel biological response modifiers: phthalimides with TNF-alpha production regulating activity]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1997;117(2):91-107.
1997: Nakajima O; Iwasaki S; Hashimoto Y
Hemin-induced erythroid differentiation of human myeloleukemia K562 cell line and its modification by bioresponse modifiers.
Cellular and molecular biology (Noisy-le-Grand, France) 1997;43(1):115-34.
1997: Kagechika H; Kawachi E; Fukasawa H; Saito G; Iwanami N; Umemiya H; Hashimoto Y; Shudo K
Inhibition of IL-1-induced IL-6 production by synthetic retinoids.
Biochemical and biophysical research communications 1997;231(2):243-8.
1997: Morita K; Koiso Y; Hashimoto Y; Kobayashi M; Wang W; Ohyabu N; Iwasaki S
Interaction of arenastatin A with porcine brain tubulin.
Biological & pharmaceutical bulletin 1997;20(2):171-4.
1997: Azuma A; Ando Y; Iwasaki S; Hashimoto Y; Yamaguchi M; Takehana S; Fukasawa H; Endo Y; Shudo K
Photoaffinity labeling of tumor promoter-binding protein (CN-TPBP) and preparation of affinity sorbent gels.
Biological & pharmaceutical bulletin 1997;20(1):6-9.
1997: Ito T; Shirai R; Hashimoto Y; Iwasaki S
Non-intercalative and sequence selective interaction between four intercalative reagents and dinucleotides.
Nucleic acids symposium series 1997;(37):79-80.
1996: Umemiya H; Kagechika H; Fukasawa H; Hashimoto Y; Shudo K
[Retinoid antagonists]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1996;116(12):928-41.
1996: Watanabe T; Sunaga S; Togo M; Satoh H; Higashihara M; Hashimoto Y; Kurokawa K
Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s.
Biochimica et biophysica acta 1996;1304(2):161-9.
1996: Watanabe T; Satoh H; Togoh M; Taniguchi S; Hashimoto Y; Kurokawa K
Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells.
Journal of cellular physiology 1996;169(2):401-9.
1996: Hashimoto Y; Shudo K
Chemistry of biologically active benzoxazinoids.
Phytochemistry 1996;43(3):551-9.
1996: Hashimoto Y; Kagechika H; Kawachi E; Fukasawa H; Saito G; Shudo K
Evaluation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Biological & pharmaceutical bulletin 1996;19(10):1322-8.
1996: Fukutomi R; Kagechika H; Hashimoto Y; Shudo K
Novel aromatic urea derivatives with DNA-binding ability.
Chemical & pharmaceutical bulletin 1996;44(10):1983-5.
1996: Miyachi H; Azuma A; Hioki E; Kobayashi Y; Iwasaki S; Hashimoto Y
Inducer-specific regulators of tumor necrosis factor alpha production.
Chemical & pharmaceutical bulletin 1996;44(10):1980-2.
1996: Miyachi H; Azuma A; Hioki E; Iwasaki S; Kobayashi Y; Hashimoto Y
Cell type-/inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production and its enantio-dependence.
Biochemical and biophysical research communications 1996;226(2):439-44.
1996: Azuma A; Miyachi H; Shibata Y; Hashimoto Y; Iwasaki S
Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message.
Biological & pharmaceutical bulletin 1996;19(7):1001-3.
1996: Miyachi H; Azuma A; Hioki E; Iwasaki S; Kobayashi Y; Hashimoto Y
Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production.
Biochemical and biophysical research communications 1996;224(2):426-30.
1996: Nakayama T; Hashimoto Y; Kaneko Y; Kurokawa K
K252a inhibits the phosphorylation of pRb without changing the levels of G1 cyclins and Cdk2 protein in human hepatoma cells.
Biochemical and biophysical research communications 1996;224(1):180-3.
1996: Sasaki T; Shimazawa R; Sawada T; Iljima T; Fukasawa H; Shudo K; Hashimoto Y; Iwasaki S
Location of two photoaffinity-labeled sites on the ligand-binding domain of retinoic acid receptor alpha.
Biological & pharmaceutical bulletin 1996;19(5):659-64.
1996: Iwanami N; Hashimoto Y; Shudo K
meso-DNAs with homopurine sequences: analysis of their interaction with natural DNAs.
Chemical & pharmaceutical bulletin 1996;44(5):919-26.
1996: Shibata Y; Sasaki K; Hashimoto Y; Iwasaki S
Phenylphthalimides with tumor necrosis factor alpha production-enhancing activity.
Chemical & pharmaceutical bulletin 1996;44(1):156-62.
1995: Kobayashi H; Morisaki N; Tago Y; Hashimoto Y; Iwasaki S; Kawachi E; Nagata R; Shudo K
Identification of a major cytokinin in coconut milk.
Experientia 1995;51(11):1081-4.
1995: Hashimoto Y; Futamura A; Ikushima M
Effect of aging on HbA1c in a working male Japanese population.
Diabetes care 1995;18(10):1337-40.
1995: Umemiya H; Kawachi E; Kagechika H; Fukasawa H; Hashimoto Y; Shudo K
Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60.
Chemical & pharmaceutical bulletin 1995;43(10):1827-9.
1995: Sasaki K; Shibata Y; Hashimoto Y; Iwasaki S
Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor alpha.
Biological & pharmaceutical bulletin 1995;18(9):1228-33.
1995: Hagiwara S; Sakurai T; Tashiro F; Hashimoto Y; Matsuda Y; Nonomura Y; Miyazaki J
An inhibitory role for phosphatidylinositol 3-kinase in insulin secretion from pancreatic B cell line MIN6.
Biochemical and biophysical research communications 1995;214(1):51-9.
1995: Nakajima O; Hashimoto Y; Iwasaki S
Possible involvement of peripheral-type benzodiazepine receptors in erythroid differentiation of human leukemia cell line, K562.
Biological & pharmaceutical bulletin 1995;18(6):903-6.
1995: Li Y; Koiso Y; Kobayashi H; Hashimoto Y; Iwasaki S
Ustiloxins, new antimitotic cyclic peptides: interaction with porcine brain tubulin.
Biochemical pharmacology 1995;49(10):1367-72.
1995: Shichita M; Shimazawa R; Nakajima O; Mizoguchi H; Hashimoto Y; Iwasaki S
Non-intercalative and sequence-selective interaction of nitropyrene/acridine-skeleton with nucleotides: application of the dextran-coupling method.
Biological & pharmaceutical bulletin 1995;18(4):637-9.
1995: Hashimoto Y; Ishizaki T; Shudo K
[Chemistry of benzoxazinoids produced by plants as phytoalexin]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1995;115(3):189-200.
1995: Sasaki T; Shimazawa R; Sawada T; Iijima T; Fukasawa H; Shudo K; Hashimoto Y; Iwasaki S
Determination of the photoaffinity-labeled site on the ligand-binding domain of retinoic acid receptor alpha.
Biochemical and biophysical research communications 1995;207(1):444-51.
1995: Shibata Y; Shichita M; Sasaki K; Nishimura K; Hashimoto Y; Iwasaki S
N-Alkylphthalimides: structural requirement of thalidomidal action on 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by human leukemia HL-60 cells.
Chemical & pharmaceutical bulletin 1995;43(1):177-9.
1995: Nakajima O; Kagechika H; Shudo K; Hashimoto Y; Iwasaki S
Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.
Biochemical and biophysical research communications 1995;206(3):1003-10.
1995: Shirai R; Shimazawa R; Shichita M; Takahashi M; Hashimoto Y; Iwasaki S
Cytotoxicity and DNA-binding property of non-diynene class of dynemicins and aza-anthraquinones.
Nucleic acids symposium series 1995;(34):151-2.
1995: Nakajima O; Shichita M; Iwasaki S; Hashimoto Y
Application of the dextran coupling method for analysis of interactions between intercalators and nucleotides.
Nucleic acids symposium series 1995;(34):137-8.
1995: Umemiya H; Komatsu K; Yamazaki T; Kagechika H; Shudo K; Hashimoto Y
Synthesis of oligopeptides as polynucleotide analogs.
Nucleic acids symposium series 1995;(34):37-8.
1995: Hashimoto Y; Kagechika H; Kawachi E; Fukasawa H; Saito G; Shudo K
Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Journal of cancer research and clinical oncology 1995;121(11):696-8.
1994: Li Y; Kobayashi H; Hashimoto Y; Shirai R; Hirata A; Hayashi K; Hamada Y; Shioiri T; Iwasaki S
Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding.
Chemico-biological interactions 1994;93(3):175-83.
1994: Shibata Y; Sasaki K; Hashimoto Y; Iwasaki S
Tumor necrosis factor alpha production enhancers with a phenylphthalimide skeleton.
Biochemical and biophysical research communications 1994;205(3):1992-7.
1994: Eyrolles L; Kawachi E; Kagechika H; Hashimoto Y; Shudo K
Synthesis and biological activity of carboxyphenylquinolines and related compounds as new potent retinoids. Retinobenzoic acids. VII.
Chemical & pharmaceutical bulletin 1994;42(12):2575-81.
1994: Shibata Y; Sasaki K; Nishimura K; Hashimoto Y; Iwasaki S
Enhancement of phorbol ester-induced production of tumor necrosis factor-alpha by 2,6-dimethylphenylphthalimide.
Biological & pharmaceutical bulletin 1994;17(11):1532-4.
1994: Hashimoto Y; Nishiyama M; Horinouchi S; Beppu T
Nitrile hydratase gene from Rhodococcus sp. N-774 requirement for its downstream region for efficient expression.
Bioscience, biotechnology, and biochemistry 1994;58(10):1859-65.
1994: Hashimoto Y; Sasaki H; Togo M; Tsukamoto K; Horie Y; Fukata H; Watanabe T; Kurokawa K
Roles of myosin light-chain kinase in platelet shape change and aggregation.
Biochimica et biophysica acta 1994;1223(2):163-9.
1994: Sasaki K; Shibata Y; Nishimura K; Hashimoto Y; Iwasaki S
Enhancement of 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by phenethylphthalimide analogs.
Biological & pharmaceutical bulletin 1994;17(9):1313-5.
1994: Matsushima Y; Fukasawa H; Endo Y; Hashimoto Y; Shudo K
Enhancement of human papillomavirus type 18 gene expression in HeLa cells by 12-O-tetradecanoylphorbol-13-acetate, 3 beta,5 alpha-dihydroxycholestan-6-one, and cholesterol.
Biological & pharmaceutical bulletin 1994;17(9):1292-5.
1994: Mizoguchi H; Fukasawa H; Steuernagel A; Yano K; Yamasaki M; Iwasaki S; Hashimoto Y
Specific binding of 12-O-tetradecanoylphorbol-13-acetate to histone H1.
Biological & pharmaceutical bulletin 1994;17(8):1114-7.
1994: Watanabe T; Nakao A; Emerling D; Hashimoto Y; Tsukamoto K; Horie Y; Kinoshita M; Kurokawa K
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
The Journal of biological chemistry 1994;269(26):17619-25.
1994: Suzuki T; Murakami M; Onai N; Fukuda E; Hashimoto Y; Sonobe M H; Kameda T; Ichinose M; Miki K; Iba H
Analysis of AP-1 function in cellular transformation pathways.
Journal of virology 1994;68(6):3527-35.
1994: Hashimoto Y
[Chemical control of gene expression]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1994;114(6):357-73.
1994: Hashimoto Y; Togo M; Tsukamoto K; Horie Y; Watanabe T; Kurokawa K
Protein kinase C-dependent and -independent mechanisms of dense granule exocytosis by human platelets.
Biochimica et biophysica acta 1994;1222(1):56-62.
1994: Eyrolles L; Kagechika H; Kawachi E; Fukasawa H; Iijima T; Matsushima Y; Hashimoto Y; Shudo K
Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring.
Journal of medicinal chemistry 1994;37(10):1508-17.
1994: Nishimura K; Hashimoto Y; Iwasaki S
(S)-form of alpha-methyl-N(alpha)-phthalimidoglutarimide, but not its (R)-form, enhanced phorbol ester-induced tumor necrosis factor-alpha production by human leukemia cell HL-60: implication of optical resolution of thalidomidal effects.
Chemical & pharmaceutical bulletin 1994;42(5):1157-9.
1994: Nakajima O; Sugishita Y; Hashimoto Y; Iwasaki S
Increase in the chemically-induced differentiation of human leukemia cell lines by tubulin disruptors.
Biological & pharmaceutical bulletin 1994;17(5):742-4.
1994: Nishimura K; Hashimoto Y; Iwasaki S
Enhancement of phorbol ester-induced production of tumor necrosis factor alpha by thalidomide.
Biochemical and biophysical research communications 1994;199(2):455-60.
1994: Endo Y; Fukasawa H; Hashimoto Y; Shudo K
Synthesis of oxygenated cholesterols as structural mimics of phorbol ester-type tumor promoters.
Chemical & pharmaceutical bulletin 1994;42(3):462-9.
1994: Nakajima O; Hashimoto Y; Iwasaki S
Erythroid differentiation-inducing activity of protoporphyrin IX and its analogs on human leukemia K562 cell line.
Biochemical and biophysical research communications 1994;198(2):720-7.
1993: Hashimoto Y; Watanabe T; Kinoshita M; Tsukamoto K; Togo M; Horie Y; Matsuda Y; Kurokawa K
Ca2+ entry pathways activated by the tumor promoter thapsigargin in human platelets.
Biochimica et biophysica acta 1993;1220(1):37-41.
1993: Ohmi K; Yamashita S; Hashimoto Y; Nonomura Y
Induction of giant endothelial cells in culture by K-252a, a protein kinase inhibitor.
Japanese journal of pharmacology 1993;63(2):195-202.
1993: Nakayama T; Hashimoto Y; Kaneko Y; Yoshida M; Beppu T; Ohmi K; Yamashita S; Nonomura Y; Kurokawa K
K252a: a new blocker of the cell-cycle at G1 phase in a human hepatoma cell line.
Experientia 1993;49(10):876-80.
1993: Nakajima O; Hashimoto Y; Iwasaki S
Enhancement by retinoid of hemin-induced differentiation of human leukemia K562 cell line.
FEBS letters 1993;330(1):81-4.
1993: Endo Y; Hashimoto Y; Fukasawa H; Shudo K
Oxygenated cholesterols as ligands for cytosolic-nuclear tumor promoter binding protein: yakkasteroids.
Biochemical and biophysical research communications 1993;194(3):1529-35.
1993: Sawada T; Kato Y; Kobayashi H; Hashimoto Y; Watanabe T; Sugiyama Y; Iwasaki S
A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin.
Bioconjugate chemistry 1993;4(4):284-9.
1993: Sawada T; Kobayashi H; Hashimoto Y; Iwasaki S
Identification of the fragment photoaffinity-labeled with azidodansyl-rhizoxin as Met-363-Lys-379 on beta-tubulin.
Biochemical pharmacology 1993;45(7):1387-94.
1993: Fukasawa H; Iijima T; Kagechika H; Hashimoto Y; Shudo K
Expression of the ligand-binding domain-containing region of retinoic acid receptors alpha, beta and gamma in Escherichia coli and evaluation of ligand-binding selectivity.
Biological & pharmaceutical bulletin 1993;16(4):343-8.
1993: Nagata R; Kawachi E; Hashimoto Y; Shudo K
Cytokinin-specific binding protein in etiolated mung bean seedlings.
Biochemical and biophysical research communications 1993;191(2):543-9.
1993: Iwanami O N; Shudo K; Hashimoto Y
Meso-oligodeoxyribonucleotides.
Nucleic acids symposium series 1993;(29):15-6.
1992: Matsushima Y; Kawachi E; Tanaka H; Kagechika H; Hashimoto Y; Shudo K
Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells.
Biochemical and biophysical research communications 1992;189(2):1136-42.
1992: Hashimoto Y; Hirohata S; Kashiwado T; Itoh K; Ishii H
Cytokine regulation of hemostatic property and IL-6 production of human endothelial cells.
Inflammation 1992;16(6):613-21.
1992: Li Y; Kobayashi H; Hashimoto Y; Iwasaki S
Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins.
Biochemical and biophysical research communications 1992;187(2):722-9.
1992: Hashimoto Y; Ogihara A; Nakanishi S; Matsuda Y; Kurokawa K; Nonomura Y
Two thrombin-activated Ca2+ channels in human platelets.
The Journal of biological chemistry 1992;267(24):17078-81.
1992: Hashimoto Y; Nishiyama M; Yu F; Watanabe I; Horinouchi S; Beppu T
Development of a host-vector system in a Rhodococcus strain and its use for expression of the cloned nitrile hydratase gene cluster.
Journal of general microbiology 1992;138(5):1003-10.
1992: Tanaka H; Kagechika H; Kawachi E; Fukasawa H; Hashimoto Y; Shudo K
Base-catalyzed isomerization of retinoic acid. Synthesis and differentiation-inducing activities of 14-alkylated all-trans-, 13-cis-, and 20,14-retro-retinoic acids.
Journal of medicinal chemistry 1992;35(3):567-72.
1992: Li Y; Kobayashi H; Tokiwa Y; Hashimoto Y; Iwasaki S
Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site.
Biochemical pharmacology 1992;43(2):219-24.
1991: Hashimoto Y; Nakayama T; Teramoto T; Kato H; Watanabe T; Kinoshita M; Tsukamoto K; Tokunaga K; Kurokawa K; Nakanishi S
Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926.
Biochemical and biophysical research communications 1991;181(1):423-9.
1991: Shimazawa R; Hibino S; Mizoguchi H; Hashimoto Y; Iwasaki S; Kagechika H; Shudo K
Fluorescent probes for retinoic acid receptors: molecular measures for the ligand binding pocket.
Biochemical and biophysical research communications 1991;180(1):249-54.
1991: Hashimoto Y; Shudo K
[Retinoids and acute promyelocytic leukemia]
Gan to kagaku ryoho. Cancer & chemotherapy 1991;18(13):2203-9.
1991: Shimazawa R; Sanda R; Mizoguchi H; Hashimoto Y; Iwasaki S; Tanaka H; Kagechika H; Shudo K
Fluorescent and photoaffinity labeling probes for retinoic acid receptors.
Biochemical and biophysical research communications 1991;179(1):259-65.
1991: Sawada T; Hashimoto Y; Li Y; Kobayashi H; Iwasaki S
Fluorescent and photoaffinity labeling derivatives of rhizoxin.
Biochemical and biophysical research communications 1991;178(2):558-62.
1991: Hashimoto Y; Shudo K
Cytosolic-nuclear tumor promoter-specific binding protein: association with the 90 kDa heat shock protein and translocation into nuclei by treatment with 12-O-tetradecanoylphorbol 13-acetate.
Japanese journal of cancer research : Gann 1991;82(6):665-75.
1991: Hashimoto Y
Retinobenzoic acids and nuclear retinoic acid receptors.
Cell structure and function 1991;16(2):113-23.
1991: Hashimoto Y; Nishiyama M; Ikehata O; Horinouchi S; Beppu T
Cloning and characterization of an amidase gene from Rhodococcus species N-774 and its expression in Escherichia coli.
Biochimica et biophysica acta 1991;1088(2):225-33.
1991: Suzuki T; Hashimoto Y; Okuno H; Sato H; Nishina H; Iba H
High-level expression of human c-jun gene causes cellular transformation of chicken embryo fibroblasts.
Japanese journal of cancer research : Gann 1991;82(1):58-64.
1991: Akimoto J; Ikeda K; Tomonaga M; Saito F; Miwa T; Awaya A; Hashimoto Y; Fukui H
[Mouse fetal brain specific protein "GP68" is expressed in human tumor cells]
No to shinkei = Brain and nerve 1991;43(1):25-9.
1991: Fujimori S; Iwanami N; Shudo K; Hashimoto Y
Enantio- and meso-oligodeoxyribonucleotides.
Nucleic acids symposium series 1991;(25):143-4.
1991: Hashimoto Y; Shudo K
Retinoids and their nuclear receptors.
Cell biology reviews : CBR 1991;25(3):209-35.
1991: Hashimoto Y; Shudo K
Retinoids and their nuclear receptors.
Cell biology reviews : CBR 1991;25(3):209-30, 233-5.
1990: Yamakawa T; Kagechika H; Kawachi E; Hashimoto Y; Shudo K
Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60.
Journal of medicinal chemistry 1990;33(5):1430-7.
1990: Hashimoto Y; Shudo K
Cytosolic-nuclear tumor promoter-specific binding protein (CN-TPBP) in human promyelocytic leukemia cells HL-60.
Biochemical and biophysical research communications 1990;166(3):1126-32.
1990: Hashimoto Y; Kagechika H; Shudo K
Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR's).
Biochemical and biophysical research communications 1990;166(3):1300-7.
1990: Fujimori S; Shudo K; Hashimoto Y
Enantio-oligodeoxyribonucleotides.
Nucleic acids symposium series 1990;(22):97-8.
1990: Kojima S; Awaya A; Ishido M; Koyama Y; Kubodera A; Hashimoto Y; Fukui H; Muramatsu H; Muramatsu T
Radioimmunoimaging of tumors with radioactive antibody against a glycoprotein (GP68) found in developing mouse brain.
Journal of cancer research and clinical oncology 1990;116(4):336-40.
1989: Hashimoto Y; Chida K; Huang M; Katayama M; Nishihira T; Kuroki T
Levels of protein kinase C activity in human gastrointestinal cancers.
Biochemical and biophysical research communications 1989;163(1):406-11.
1989: Hashimoto Y; Petkovich M; Gaub M P; Kagechika H; Shudo K; Chambon P
The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60.
Molecular endocrinology (Baltimore, Md.) 1989;3(7):1046-52.
1989: Kagechika H; Himi T; Namikawa K; Kawachi E; Hashimoto Y; Shudo K
Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids.
Journal of medicinal chemistry 1989;32(5):1098-108.
1989: Kagechika H; Kawachi E; Hashimoto Y; Shudo K
Retinobenzoic acids. 2. Structure-activity relationships of chalcone-4-carboxylic acids and flavone-4'-carboxylic acids.
Journal of medicinal chemistry 1989;32(4):834-40.
1989: Shudo K; Hashimoto Y
[DNA modification and carcinogenesis--early events caused by a heterocyclic aromatic amine, Glu-P-1]
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):445-50.
1988: Kagechika H; Kawachi E; Hashimoto Y; Himi T; Shudo K
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
Journal of medicinal chemistry 1988;31(11):2182-92.
1988: Kagechika H; Hashimoto Y; Kawachi E; Shudo K
[Recent advances in retinoids studies]
Gan to kagaku ryoho. Cancer & chemotherapy 1988;15(10):2839-47.
1988: Kagechika H; Hashimoto Y; Kawachi E; Shudo K
Affinity gels for purification of retinoid-specific binding protein (RSBP).
Biochemical and biophysical research communications 1988;155(1):503-8.
1988: Hashimoto Y; Kagechika H; Kawachi E; Shudo K
Specific uptake of retinoids into human promyelocytic leukemia cells HL-60 by retinoid-specific binding protein: possibly the true retinoid receptor.
Japanese journal of cancer research : Gann 1988;79(4):473-83.

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