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Akira Hashiramoto

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K Yoshida; T Yamane; Akira Hashiramoto; H Inoue; K Komai; K Shiozawa; S Shiozawa
Mixed connective tissue disease is distinct from systemic lupus erythematosus: study of major histocompatibility complex class I polypeptide-related sequence A and HLA gene polymorphisms.
Ryoko Sakai; Takahiko Sugihara; Takayuki Sumida; Naoto Tamura; Michi Tanaka; Yoshiya Tanaka; Shigeto Tohma; Yukitaka Ueki; Kaori Watanabe; Hayato Yamazaki; Koichi Amano; Tatsuya Atsumi; Hiroaki Dobashi; Takao Fujii; Noboru Hagino; Masayoshi Harigai; Akira Hashiramoto; Atsushi Ihata; Yoshiaki Ishigatsubo; Satoshi Ito; Atsushi Kawakami; Ryuji Koike; Takao Koike; Nobuyuki Miyasaka; Hayato Nagasawa; Atsuo Nakajima; Toshihiro Nanki; Kazuyoshi Saito
Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules.
Ryoko Sakai; Takahiko Sugihara; Takayuki Sumida; Naoto Tamura; Michi Tanaka; Yoshiya Tanaka; Shigeto Tohma; Yukitaka Ueki; Koichi Amano; Tatsuya Atsumi; Takao Fujii; Noboru Hagino; Masayoshi Harigai; Akira Hashiramoto; Atsushi Ihata; Yoshiaki Ishigatsubo; Satoshi Ito; Atsushi Kawakami; Ryuji Koike; Takao Koike; Yukiko Komano; Nobuyuki Miyasaka; Kenji Nagasaka; Hayato Nagasawa; Atsuo Nakajima; Toshihiro Nanki; Kazuyoshi Saito
Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis.

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2013: K Yoshida; T Yamane; Akira Hashiramoto; H Inoue; K Komai; K Shiozawa; S Shiozawa
Mixed connective tissue disease is distinct from systemic lupus erythematosus: study of major histocompatibility complex class I polypeptide-related sequence A and HLA gene polymorphisms.
Tissue antigens 2013;81(1):44-5.
2012: Ryoko Sakai; Takahiko Sugihara; Takayuki Sumida; Naoto Tamura; Michi Tanaka; Yoshiya Tanaka; Shigeto Tohma; Yukitaka Ueki; Kaori Watanabe; Hayato Yamazaki; Koichi Amano; Tatsuya Atsumi; Hiroaki Dobashi; Takao Fujii; Noboru Hagino; Masayoshi Harigai; Akira Hashiramoto; Atsushi Ihata; Yoshiaki Ishigatsubo; Satoshi Ito; Atsushi Kawakami; Ryuji Koike; Takao Koike; Nobuyuki Miyasaka; Hayato Nagasawa; Atsuo Nakajima; Toshihiro Nanki; Kazuyoshi Saito
Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules.
Annals of the rheumatic diseases 2012;71(11):1820-6.
2012: Ryoko Sakai; Takahiko Sugihara; Takayuki Sumida; Naoto Tamura; Michi Tanaka; Yoshiya Tanaka; Shigeto Tohma; Yukitaka Ueki; Koichi Amano; Tatsuya Atsumi; Takao Fujii; Noboru Hagino; Masayoshi Harigai; Akira Hashiramoto; Atsushi Ihata; Yoshiaki Ishigatsubo; Satoshi Ito; Atsushi Kawakami; Ryuji Koike; Takao Koike; Yukiko Komano; Nobuyuki Miyasaka; Kenji Nagasaka; Hayato Nagasawa; Atsuo Nakajima; Toshihiro Nanki; Kazuyoshi Saito
Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis.
Arthritis care & research 2012;64(8):1125-34.
2012: Chihiro Tanaka; Akira Hashiramoto; Kazuko Shiozawa; Shunichi Shiozawa
A study on the selection of DMARDs for the combination therapy with adalimumab.
The Kobe journal of medical sciences 2012;58(2):E41-50.
2011: Kohsuke Yoshida; Yuki Tanaka; Akira Hashiramoto; Takahiko Horiuchi; Koichiro Komai; Aya Mashida; Masato Nose; Kazuko Shiozawa; Shunichi Shiozawa
Role of the MICA polymorphism in systemic lupus erythematosus.
Arthritis and rheumatism 2011;63(10):3058-66.
2011: Yukiko Komano; Nobuyuki Miyasaka; Atsuo Nakajima; Toshihiro Nanki; Kazuyoshi Saito; Ryoko Sakai; Tetsuji Sawada; Mitsuhiro Takeno; Tsutomu Takeuchi; Naoto Tamura; Michi Tanaka; Yoshiya Tanaka; Shigeto Tohma; Tatsuya Atsumi; Katsumi Eguchi; Takao Fujii; Masayoshi Harigai; Akira Hashiramoto; Hiroaki Ida; Yoshiaki Ishigatsubo; Satoshi Ito; Hideto Kameda; Ryuji Koike; Takao Koike
Incidence and risk factors for serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a report from the Registry of Japanese Rheumatoid Arthritis Patients for Longterm Safety.
The Journal of rheumatology 2011;38(7):1258-64.
2011: Akira Hashiramoto; Miki Murata; Takako Kawazoe; Kohsuke Yoshida; Chieri Akiyama; Kazuko Shiozawa; Shunichi Shiozawa
Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B.
Rheumatology (Oxford, England) 2011;50(5):852-61.
2011: Shunichi Shiozawa; Ken Tsumiyama; Kohsuke Yoshida; Akira Hashiramoto
Pathogenesis of joint destruction in rheumatoid arthritis.
Archivum immunologiae et therapiae experimentalis 2011;59(2):89-95.
2010: Shunichi Shiozawa; Akira Hashiramoto
Interactions between the genes that regulate the body clock and those that worsen rheumatoid arthritis.
Expert review of clinical immunology 2010;6(2):181-3.
2010: Akira Hashiramoto; Takashi Yamane; Ken Tsumiyama; Kohsuke Yoshida; Koichiro Komai; Hiroyuki Yamada; Fumiyoshi Yamazaki; Masao Doi; Hitoshi Okamura; Shunichi Shiozawa
Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1560-5.
2009: Akira Hashiramoto; Kazuko Shiozawa; Yasushi Tanaka; Takashi Yamane; Miki Murata; Chihiro Tanaka; Yasuhiro Terashima; Kozo Koyama; Natsuko Nakagawa; Shuji Abe; Rhosuke Yoshihara; Yasuhiro Saegusa; Ken Tsumiyama; Koichiro Komai; Yoshitada Sakai; Shunichi Shiozawa
Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose.
Modern rheumatology / the Japan Rheumatism Association 2009;19(6):637-42.
2009: Koichiro Komai; Kazuko Shiozawa; Yasushi Tanaka; Ryosuke Yoshihara; Chihiro Tanaka; Hideo Sakai; Takashi Yamane; Miki Murata; Ken Tsumiyama; Akira Hashiramoto; Shunichi Shiozawa
Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment.
Modern rheumatology / the Japan Rheumatism Association 2009;19(4):416-9.
2008: Ilia J Elenkov; Richard Kvetnansky; Akira Hashiramoto; Vladimir K Bakalov; Amrey A Link; Keith Zachman; M Crane; Daniela Jezova; Jozef Rovensky; Mariana A Dimitrov; Philip W Gold; Sergio Bonini; Thomas A Fleisher; George Chrousos; Ronald L Wilder
Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1737-45.
2008: Yukihiko Aikawa; Kimiko Morimoto; Tetsuya Yamamoto; Hisaaki Chaki; Akira Hashiramoto; Hirokazu Narita; Shuichi Hirono; Shunichi Shiozawa
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1.
Nature biotechnology 2008;26(7):817-23.
2008: Takashi Yamane; Akira Hashiramoto; Yasushi Tanaka; Ken Tsumiyama; Yasushi Miura; Kazuko Shiozawa; Kazuo Chihara; Shunichi Shiozawa
Easy and accurate diagnosis of rheumatoid arthritis using anti-cyclic citrullinated peptide 2 antibody, swollen joint count, and C-reactive protein/rheumatoid factor.
The Journal of rheumatology 2008;35(3):414-20.
2007: Akira Hashiramoto; China Sakai; Kohsuke Yoshida; Ken Tsumiyama; Yasushi Miura; Kazuko Shiozawa; Masato Nose; Koichiro Komai; Shunichi Shiozawa
Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt.
Arthritis and rheumatism 2007;56(7):2170-9.
2007: Shinya Hayashi; Yasushi Miura; Takayuki Nishiyama; Makoto Mitani; Koji Tateishi; Yoshitada Sakai; Akira Hashiramoto; Masahiro Kurosaka; Shunichi Shiozawa; Minoru Doita
Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against Fas-induced apoptosis.
Arthritis and rheumatism 2007;56(4):1067-75.
2006: Akira Hashiramoto; Hiroki Mizukami; Tadashi Yamashita
Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.
Oncogene 2006;25(28):3948-55.
2006: Atsushi Kitagawa; Yasushi Miura; Ryuichi Saura; Makoto Mitani; H Ishikawa; Akira Hashiramoto; Shinichi Yoshiya; Shunichi Shiozawa; Masahiro Kurosaka
Anchorage on fibronectin via VLA-5 (alpha5beta1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis.
Annals of the rheumatic diseases 2006;65(6):721-7.
2006: Nozomi Takami; Kayo Osawa; Yasushi Miura; Koichiro Komai; Mariko Taniguchi; Masahiko Shiraishi; Keizo Sato; Tetsuhiro Iguchi; Kazuko Shiozawa; Akira Hashiramoto; Shunichi Shiozawa
Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells.
Arthritis and rheumatism 2006;54(3):779-87.
2005: Akira Hashiramoto; Koichiro Komai; Shunichi Shiozawa
[Molecular genetics of rheumatic diseases].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 12():228-31.
2005: Makoto Mitani; Yasushi Miura; Ryuichi Saura; Atsushi Kitagawa; Taihei Fukuyama; Akira Hashiramoto; Shunichi Shiozawa; Masahiro Kurosaka; Shinichi Yoshiya
Estrogen specifically stimulates expression and production of osteoprotegerin from rheumatoid synovial fibroblasts.
International journal of molecular medicine 2005;15(5):827-32.
2005: Miki Murata; Yasushi Miura; Akira Hashiramoto; Hitomi Kitamura; Hiroki Kawasaki; Kazuko Shiozawa; Shinichi Yoshiya; Hisamitsu Baba; Kazuo Chihara; Shunichi Shiozawa
Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli.
International journal of molecular medicine 2005;15(4):649-53.
2005: Kazuko Shiozawa; Yasushi Tanaka; Ryosuke Yoshihara; Shigeaki Imura; Miki Murata; Takashi Yamane; Yasushi Miura; Akira Hashiramoto; Shunichi Shiozawa
Serum levels and pharmacodynamics of methotrexate and its metabolite 7-hydroxy methotrexate in Japanese patients with rheumatoid arthritis treated with 2-mg capsule of methotrexate three times per week.
Modern rheumatology / the Japan Rheumatism Association 2005;15(6):405-9.
2005: Shunichi Shiozawa; Akira Hashiramoto; Kayo Osawa; Nozomi Takami; Yasushi Miura; Masahiro Kurosaka; Shinichi Yoshiya; Kozo Koyama; Yasuhiro Terashima; Shuji Abe; Natsuko Nakagawa; Yasuhiro Saegusa; Yasushi Tanaka; Kazuko Shiozawa; Tetsuhiro Iguchi
[Susceptibility genes in rheumatoid arthritis: mutation in DR3 gene].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 1():122-6.
2004: Kayo Osawa; Nozomi Takami; Kazuko Shiozawa; Akira Hashiramoto; Shunichi Shiozawa
Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis.
Genes and immunity 2004;5(6):439-43.
2003: Hiroki Kawasaki; Koichiro Komai; Mikiko Nakamura; Eri Yamamoto; Zhufeng Ouyang; Toshie Nakashima; Tae Morisawa; Akira Hashiramoto; Kazuko Shiozawa; Hitoshi Ishikawa; Masahiro Kurosaka; Shunichi Shiozawa
Human wee1 kinase is directly transactivated by and increased in association with c-Fos/AP-1: rheumatoid synovial cells overexpressing these genes go into aberrant mitosis.
Oncogene 2003;22(44):6839-44.
2003: Mari Hikasa; Eri Yamamoto; Hiroki Kawasaki; Koichiro Komai; Kazuko Shiozawa; Akira Hashiramoto; Yasushi Miura; Shunichi Shiozawa
p21waf1/cip1 is down-regulated in conjunction with up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients.
Biochemical and biophysical research communications 2003;304(1):143-7.
2003: Tadashi Yamashita; Akira Hashiramoto; Martin Haluzik; Hiroki Mizukami; Shoshannah Beck; Aaron Norton; Mari Kono; Shuichi Tsuji; Jose L Daniotti; Norbert Werth; Roger Sandhoff; Konrad Sandhoff; Richard L Proia
Enhanced insulin sensitivity in mice lacking ganglioside GM3.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3445-9.
2003: Shunichi Shiozawa; Yasushi Miura; Akira Hashiramoto; Miki Murata; Chihiro Takabayashi; Kazuko Shiozawa; Yasuo Kuroki
Fasciitis: what is the significance of various forms?
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2003;9(1):1-3.
2002: David E Dobbins; bina joe; Akira Hashiramoto; Jennifer L Salstrom; Svetlana Dracheva; Lynn Ge; Ronald L Wilder; Elaine F Remmers
Localization of the mutation responsible for osteopetrosis in the op rat to a 1.5-cM genetic interval on rat chromosome 10: identification of positional candidate genes by radiation hybrid mapping.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(10):1761-7.
2002: Elaine F Remmers; bina joe; Marie M Griffiths; David E Dobbins; Svetlana Dracheva; Akira Hashiramoto; Takefumi Furuya; Jennifer L Salstrom; JianPing Wang; Pércio S Gulko; Grant W Cannon; Ronald L Wilder
Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females.
Arthritis and rheumatism 2002;46(8):2225-34.
2002: David E Dobbins; Raman Sood; Akira Hashiramoto; Carl T Hansen; Ronald L Wilder; Elaine F Remmers
Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat.
Biochemical and biophysical research communications 2002;294(5):1114-20.
2002: Elaine F Remmers; Carl T Hansen; Akira Hashiramoto; Ronald L Wilder; David E Dobbins
Application of interval haplotype analysis facilitates efficient mapping of the mutation causing osteopetrosis in tl rats.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(6):299-301.
2001: M Kohno; Y Aikawa; Yasunori Tsubouchi; Akira Hashiramoto; R Yamada; Yutaka Kawahito; K Inoue; Y Kusaka; M Kondo; H Sano
Inhibitory effect of T-614 on tumor necrosis factor-alpha induced cytokine production and nuclear factor-kappaB activation in cultured human synovial cells.
The Journal of rheumatology 2001;28(12):2591-6.
2001: M Kohno; Yutaka Kawahito; Yasunori Tsubouchi; Akira Hashiramoto; R Yamada; K I Inoue; Y Kusaka; T Kubo; I J Elenkov; George Chrousos; M Kondo; H Sano
Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity.
The Journal of clinical endocrinology and metabolism 2001;86(9):4344-52.
2001: Takefumi Furuya; Jennifer L Salstrom; bina joe; Akira Hashiramoto; David E Dobbins; Ronald L Wilder; Elaine F Remmers
Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains.
Immunogenetics 2001;53(5):427-9.
2001: Takefumi Furuya; bina joe; Jennifer L Salstrom; Akira Hashiramoto; David E Dobbins; Ronald L Wilder; Elaine F Remmers
Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains.
Genes and immunity 2001;2(4):229-32.
2000: Yutaka Kawahito; M Kondo; Yasunori Tsubouchi; Akira Hashiramoto; D Bishop-Bailey; K Inoue; M Kohno; R Yamada; timothy hla; H Sano
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
The Journal of clinical investigation 2000;106(2):189-97.
2000: Marie M Griffiths; JianPing Wang; bina joe; Svetlana Dracheva; Yutaka Kawahito; JS Shepard; Van Reese; S McCall-Vining; Akira Hashiramoto; Grant W Cannon; Elaine F Remmers; Ronald L Wilder
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis.
Arthritis and rheumatism 2000;43(6):1278-89.
2000: Yasunori Tsubouchi; H Sano; R Yamada; Akira Hashiramoto; M Kohno; Y Kusaka; M Kondo
Preferential inhibition of cyclooxygenase-2 by meloxicam in human rheumatoid synoviocytes.
European journal of pharmacology 2000;395(3):255-63.
2000: R Yamada; H Sano; timothy hla; Akira Hashiramoto; Yutaka Kawahito; S Mukai; M Kohno; Yasunori Tsubouchi; M Inoue; A Komatsu; K Inoue; M Kondo
Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis.
Biochemical and biophysical research communications 2000;269(2):415-21.
1999: R Yamada; H Sano; timothy hla; Akira Hashiramoto; W Fukui; S Miyazaki; M Kohno; Yasunori Tsubouchi; Y Kusaka; M Kondo
Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes.
European journal of pharmacology 1999;385(1):71-9.
1999: Akira Hashiramoto; H Sano; T Maekawa; Yutaka Kawahito; S Kimura; Y Kusaka; Ronald L Wilder; H Kato; M Kondo; H Nakajima
C-myc antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes.
Arthritis and rheumatism 1999;42(5):954-62.
1999: Kyoichi Kassai; Toshikazu Yoshikawa; Norimasa Yoshida; Akira Hashiramoto; M Kondo; Hironobu Murase
Helicobacter pylori water extract induces interleukin-8 production by gastric epithelial cells.
Digestive diseases and sciences 1999;44(2):237-42.
1998: W Fukui; H Sano; T Tanabe; T Ueda; S Hirohata; Akira Hashiramoto; R Yamada; H Kato; M Kondo
[A case of severe neuropsychiatric lupus erythematosus treated by plasmapheresis: diagnostic values of serum antiribosomal P protein antibodies and interleukin-6 in cerebrospinal fluid].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1998;21(4):172-9.
1998: Kenji Kamiuchi; H Sano; Akira Hashiramoto; Y Takahashi; H Onodera; Y Kobayashi; K Yanagida; H Kato; M Kondo
[A case of systemic lupus erythematosus complicated with marked intestinal edema and paralytic ileus].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1998;21(1):48-56.
1996: H Kata; M Inoue; S Mukai; Y Kawahito; T Yoshida; K Asai; S Kimura; Akira Hashiramoto; Y Yamamura; H Sano; S Sugino; M Kondo
Morphological study of cytotoxicity produced by PSK-induced polymorphonuclear leukocytes (PMNs) and Nocardia rubra cell wall skeleton.
Biotherapy (Dordrecht, Netherlands) 1996;9(4):229-39.
1995: H Sano; Y Kawahito; Ronald L Wilder; Akira Hashiramoto; S Mukai; K Asai; S Kimura; H Kato; M Kondo; T Hla
Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
Cancer research 1995;55(17):3785-9.