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Andrej Hasilik

Research Profile

Chemicals & Drugs

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Alessandro Magini; Alice Polchi; Brunella Tancini; Lorena Urbanelli; Andrej Hasilik; Carla Emiliani
Glycohydrolases β-hexosaminidase and β-galactosidase are associated with lipid microdomains of Jurkat T-lymphocytes.
Lalu Rudyat Telly Savalas; Christian Wrocklage; Markus Damme; Cécile Debacker; Bruno Gasnier; Andrej Hasilik; Adrien Jézégou; Torben Lübke; Thomas Reinheckel; Paul Saftig; Bernd Schröder
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
Prajna Jena; Bibhuti Mishra; Matthias Leippe; Andrej Hasilik; Gareth Griffiths; Avinash Sonawane
Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria.

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All Publications

2012: Alessandro Magini; Alice Polchi; Brunella Tancini; Lorena Urbanelli; Andrej Hasilik; Carla Emiliani
Glycohydrolases β-hexosaminidase and β-galactosidase are associated with lipid microdomains of Jurkat T-lymphocytes.
Biochimie 2012;94(3):684-94.
2011: Lalu Rudyat Telly Savalas; Christian Wrocklage; Markus Damme; Cécile Debacker; Bruno Gasnier; Andrej Hasilik; Adrien Jézégou; Torben Lübke; Thomas Reinheckel; Paul Saftig; Bernd Schröder
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
The Biochemical journal 2011;439(1):113-28.
2011: Prajna Jena; Bibhuti Mishra; Matthias Leippe; Andrej Hasilik; Gareth Griffiths; Avinash Sonawane
Membrane-active antimicrobial peptides and human placental lysosomal extracts are highly active against mycobacteria.
Peptides 2011;32(5):881-7.
2010: Bernd A Schröder; Christian Wrocklage; Andrej Hasilik; Paul Saftig
The proteome of lysosomes.
Proteomics 2010;10(22):4053-76.
2010: Bernd Schröder; Christian Wrocklage; Andrej Hasilik; Paul Saftig
Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane.
Biological chemistry 2010;391(6):695-704.
2009: Daniela Fabrino; Christopher K E Bleck; Elsa Anes; Andrej Hasilik; Rossana C N Melo; Michael Niederweis; Gareth Griffiths; Maximiliano Gutierrez
Porins facilitate nitric oxide-mediated killing of mycobacteria.
Microbes and infection / Institut Pasteur 2009;11(10-11):868-75.
2009: Oliver Schieweck; Markus Damme; Bernd Schröder; Andrej Hasilik; Bernhard Schmidt; Torben Lübke
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.
The Biochemical journal 2009;422(1):83-90.
2009: Ulrich Matzner; Bernadette Breiden; Günter Schwarzmann; Afshin Yaghootfam; Arvan L Fluharty; Andrej Hasilik; Konrad Sandhoff; Volkmar Gieselmann
Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.
The Journal of biological chemistry 2009;284(14):9372-81.
2009: Andrej Hasilik; Christian Wrocklage; Bernd Schröder
Intracellular trafficking of lysosomal proteins and lysosomes.
International journal of clinical pharmacology and therapeutics 2009;47 Suppl 1():S18-33.
2008: Alessandro Magini; Simona Mencarelli; Brunella Tancini; Virginia Ciccarone; Lorena Urbanelli; Andrej Hasilik; Carla Emiliani
Identification and characterization of mature beta-hexosaminidases associated with human placenta lysosomal membrane.
Bioscience reports 2008;28(4):229-37.
2008: Lorena Urbanelli; Carla Emiliani; Carlo Massini; Emanuele Persichetti; Antonio Orlacchio; Giuliana Pelicci; Sandro Sorbi; Andrej Hasilik; Giorgio Bernardi; Aldo Orlacchio
Cathepsin D expression is decreased in Alzheimer's disease fibroblasts.
Neurobiology of aging 2008;29(1):12-22.
2007: Ozlem Demirel; Zoe Waibler; Ulrich Kalinke; Frank Grünebach; Silke Appel; Peter Brossart; Andrej Hasilik; Robert Tampé; Rupert Abele
Identification of a lysosomal peptide transport system induced during dendritic cell development.
The Journal of biological chemistry 2007;282(52):37836-43.
2007: Bernd Schröder; Christian Wrocklage; Cuiping Pan; Ralf Jäger; Bernd Kösters; Helmut Schäfer; Hans-Peter Elsässer; Matthias Mann; Andrej Hasilik
Integral and associated lysosomal membrane proteins.
Traffic (Copenhagen, Denmark) 2007;8(12):1676-86.
2007: Olga Schestkowa; Dominik Geisel; Ralf Jacob; Andrej Hasilik
The catalytically inactive precursor of cathepsin D induces apoptosis in human fibroblasts and HeLa cells.
Journal of cellular biochemistry 2007;101(6):1558-66.
2007: Peter Lemansky; Ines Fester; Eva Smolenova; Christoph Uhländer; Andrej Hasilik
The cation-independent mannose 6-phosphate receptor is involved in lysosomal delivery of serglycin.
Journal of leukocyte biology 2007;81(4):1149-58.
2007: Peter Lemansky; Eva Smolenova; Christian Wrocklage; Andrej Hasilik
Neutrophil elastase is associated with serglycin on its way to lysosomes in U937 cells.
Cellular immunology 2007;246(1):1-7.
2007: Bernd Schröder; Hans-Peter Elsässer; Bernhard Schmidt; Andrej Hasilik
Characterisation of lipofuscin-like lysosomal inclusion bodies from human placenta.
FEBS letters 2007;581(1):102-8.
2006: Bernd Schröder; Andrej Hasilik
A protocol for combined delipidation and subfractionation of membrane proteins using organic solvents.
Analytical biochemistry 2006;357(1):144-6.
2006: Steffen Weik; Torsten Luksch; Andreas Evers; Jark Böttcher; Christoph A Sotriffer; Andrej Hasilik; Hans-Gerhard Löffler; Gerhard Klebe; Jörg Rademann
The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of C-C-coupling reagents.
ChemMedChem 2006;1(4):445-57.
2006: Marina Démoz; Roberta Castino; Carlo Follo; Andrej Hasilik; Bonnie F Sloane; Ciro Isidoro
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells.
Protein expression and purification 2006;45(1):157-67.
2005: Serkalem Tadesse; Judita Mascarenhas; Bernd Kösters; Andrej Hasilik; Peter L Graumann
Genetic interaction of the SMC complex with topoisomerase IV in Bacillus subtilis.
Microbiology (Reading, England) 2005;151(Pt 11):3729-37.
2005: Simona Mencarelli; Cristina Cavalieri; Alessandro Magini; Brunella Tancini; Luisa Basso; Peter Lemansky; Andrej Hasilik; Yu-Teh Li; Vanna Chigorno; Antonio Orlacchio; Carla Emiliani; Sandro Sonnino
Identification of plasma membrane associated mature beta-hexosaminidase A, active towards GM2 ganglioside, in human fibroblasts.
FEBS letters 2005;579(25):5501-6.
2004: Madanan Madathiparambil Gopalakrishnan; Hans-Wilhelm Grosch; Silvia Locatelli-Hoops; Norbert Werth; Eva Smolenová; Michael Nettersheim; Konrad Sandhoff; Andrej Hasilik
Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation.
The Biochemical journal 2004;383(Pt. 3):507-15.
2004: Brigitte Lankat-Buttgereit; Cornelia Gregel; A Knolle; Andrej Hasilik; Rudolf Arnold; Rüdiger Göke
Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II.
Molecular and cellular endocrinology 2004;214(1-2):149-53.
2003: Peter Lemansky; Mireille Gerecitano-Schmidek; Rajesh C Das; Bernhard Schmidt; Andrej Hasilik
Targeting myeloperoxidase to azurophilic granules in HL-60 cells.
Journal of leukocyte biology 2003;74(4):542-50.
2003: Claudine Tardy; Jaana Tyynelä; Andrej Hasilik; Thierry Levade; Nathalie Andrieu-Abadie
Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D.
Cell death and differentiation 2003;10(9):1090-100.
2003: Sanna Partanen; Stephan Storch; Hans-Gerhard Löffler; Andrej Hasilik; Jaana Tyynelä; Thomas Braulke
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells.
The Biochemical journal 2003;369(Pt 1):55-62.
2002: Antje Taute; Kristin Wätzig; Brigitte Simons; Christiane Lohaus; Helmut Meyer; Andrej Hasilik
Presence of detergent-resistant microdomains in lysosomal membranes.
Biochemical and biophysical research communications 2002;298(1):5-9.
2002: Rainer Buchmann; Andrej Hasilik; Thomas E Van Dyke; Dieter E Lange
Amplified crevicular leukocyte activity in aggressive periodontal disease.
Journal of dental research 2002;81(10):716-21.
2002: Rainer Buchmann; Andrej Hasilik; Thomas E Van Dyke; Dieter E Lange
Resolution of crevicular fluid leukocyte activity in patients treated for aggressive periodontal disease.
Journal of periodontology 2002;73(9):995-1002.
2002: Rainer Buchmann; Andrej Hasilik; Martha E Nunn; Thomas E Van Dyke; Dieter E Lange
PMN responses in chronic periodontal disease: evaluation by gingival crevicular fluid enzymes and elastase-alpha-1-proteinase inhibitor complex.
Journal of clinical periodontology 2002;29(6):563-72.
2002: Ralph Melcher; Hans-Wilhelm Grosch; Andrej Hasilik
Plasmid vectors with a 5'-hybrid intron facilitate high-level glycoprotein expression in CHO-cells.
Biochimica et biophysica acta 2002;1575(1-3):49-53.
2001: Rainer Buchmann; Andrej Hasilik; Achim Heinecke; Dieter E Lange
PMN responses following use of 2 biodegradable GTR membranes.
Journal of clinical periodontology 2001;28(11):1050-7.
2001: Peter Lemansky; Andrej Hasilik
Chondroitin sulfate is involved in lysosomal transport of lysozyme in U937 cells.
Journal of cell science 2001;114(Pt 2):345-52.
2000: Ralph Melcher; A Hillebrand; Udo Bahr; Bernd Schröder; M Karas; Andrej Hasilik
Glycosylation-site-selective synthesis of N-acetyl-lactosamine repeats in bis-glycosylated human lysozyme.
The Biochemical journal 2000;348 Pt 3():507-15.
1998: U Bening; Roberta Castino; N Harth; Ciro Isidoro; Andrej Hasilik
Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidase.
Journal of cellular biochemistry 1998;71(2):158-68.
1998: Ralph Melcher; Hans-Wilhelm Grosch; O Grosse; Andrej Hasilik
Increased elongation of N-acetyllactosamine repeats in doubly glycosylated lysozyme with a particular spacing of the glycosylation sites.
Glycoconjugate journal 1998;15(10):987-93.
1998: J Faulhaber; A Fensom; Andrej Hasilik
Abnormal lysosomal sorting with an enhanced secretion of cathepsin D precursor molecules bearing monoester phosphate groups.
European journal of cell biology 1998;77(2):134-40.
1998: Hans-Wilhelm Grosch; Andrej Hasilik
Protection of proteolysis-prone recombinant proteins in baculovirus expression systems.
BioTechniques 1998;24(6):930-2, 934.
1998: Ciro Isidoro; Francesco M Baccino; Andrej Hasilik
Human and hamster procathepsin D, although equally tagged with mannose-6-phosphate, are differentially targeted to lysosomes in transfected BHK cells.
Cell and tissue research 1998;292(2):303-10.
1997: M Hummel; H C Hedrich; Andrej Hasilik
Elongation of N-acetyllactosamine repeats in diantennary oligosaccharides.
European journal of biochemistry / FEBS 1997;245(2):428-33.
1997: Ciro Isidoro; Francesco M Baccino; Andrej Hasilik
Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal.
International journal of cancer. Journal international du cancer 1997;70(5):561-6.
1997: Gerhard Aumüller; Heiner Renneberg; Andrej Hasilik
Distribution and subcellular localization of a lysosome-associated protein in human genital organs.
Cell and tissue research 1997;287(2):335-42.
1997: Ciro Isidoro; Marina Démoz; Daniela De Stefanis; Francesco M Baccino; Andrej Hasilik; Gabriella Bonelli
Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts.
International journal of cancer. Journal international du cancer 1997;70(3):310-4.
1996: Heinz-J Hausser; P Wedekind; T Sperber; Reiner Peters; Andrej Hasilik; Hans Kresse
Isolation and cellular localization of the decorin endocytosis receptor.
European journal of cell biology 1996;71(4):325-31.
1996: O Diettrich; F Gallert; Andrej Hasilik
Purification of lysosomal membrane proteins from human placenta.
European journal of cell biology 1996;69(2):99-106.
1995: S Raczek; Ching-Hei Yeung; Andrej Hasilik; Horst Robenek; Lothar Hertle; H Schulze; Trevor G Cooper
Immunocytochemical localisation of some lysosomal hydrolases, their presence in luminal fluid and their directional secretion by human epididymal cells in culture.
Cell and tissue research 1995;280(2):415-25.
1995: Norbert Lügering; R Stoll; A Siekmann; J Faulhaber; C Heese; O Dietrich; Torsten Kucharzik; H Busch; Andrej Hasilik; Wolfram Domschke
Elevated levels of activities of beta-hexosaminidase and alpha-mannosidase in human immunodeficiency virus-infected patients.
The Journal of infectious diseases 1995;171(3):683-6.
1995: Thorsten Marquardt; Kurt Ullrich; P Zimmer; Andrej Hasilik; T Deufel; Erik Harms
Carbohydrate-deficient glycoprotein syndrome (CDGS)--glycosylation, folding and intracellular transport of newly synthesized glycoproteins.
European journal of cell biology 1995;66(3):268-73.
1994: Heinz-J Hausser; A Gröning; Andrej Hasilik; Elke Schönherr; Hans Kresse
Selective inactivity of TGF-beta/decorin complexes.
FEBS letters 1994;353(3):243-5.
1994: J Radons; U Biewusch; Susanne Grässel; H J Geuze; Andrej Hasilik
Distinctive inhibition of the lysosomal targeting of lysozyme and cathepsin D by drugs affecting pH gradients and protein kinase C.
The Biochemical journal 1994;302 ( Pt 2)():581-6.
1993: M Horst; M Mares; M Zabe; M Hummel; B Wiederanders; H Kirschke; Andrej Hasilik
Synthesis of phosphorylated oligosaccharides in lysozyme is enhanced by fusion to cathepsin D.
The Journal of biological chemistry 1993;268(26):19690-6.
1992: J Radons; V Faber; H Buhrmester; Wolfgang Völker; V Horejsí; Andrej Hasilik
Stimulation of the biosynthesis of lactosamine repeats in glycoproteins in differentiating U937 cells and its suppression in the presence of NH4Cl.
European journal of cell biology 1992;57(2):184-92.
1992: Susanne Grässel; Andrej Hasilik
Human cathepsin D precursor is associated with a 60 kDa glycosylated polypeptide.
Biochemical and biophysical research communications 1992;182(1):276-82.
1991: M Horst; N Harth; Andrej Hasilik
Biosynthesis of glycosylated human lysozyme mutants.
The Journal of biological chemistry 1991;266(21):13914-9.
1991: B Redecker; B Heckendorf; Hans-Wilhelm Grosch; G Mersmann; Andrej Hasilik
Molecular organization of the human cathepsin D gene.
DNA and cell biology 1991;10(6):423-31.
1991: Ciro Isidoro; Susanne Grässel; Francesco M Baccino; Andrej Hasilik
Determination of the phosphorylation, uncovering of mannose 6-phosphate groups and targeting of lysosomal enzymes.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1991;29(3):165-71.
1991: Ciro Isidoro; M Horst; Francesco M Baccino; Andrej Hasilik
Differential segregation of human and hamster cathepsin D in transfected baby-hamster kidney cells.
The Biochemical journal 1991;273(Pt 2)():363-7.
1991: M Horst; Andrej Hasilik
Expression and maturation of human cathepsin D in baby-hamster kidney cells.
The Biochemical journal 1991;273(Pt 2)():355-61.
1990: Ciro Isidoro; J Radons; Francesco M Baccino; Andrej Hasilik
Suppression of the 'uncovering' of mannose-6-phosphate residues in lysosomal enzymes in the presence of NH4Cl.
European journal of biochemistry / FEBS 1990;191(3):591-7.
1990: J Radons; Ciro Isidoro; Andrej Hasilik
Brefeldin A prevents uncovering but not phosphorylation of the recognition marker in cathepsin D.
Biological chemistry Hoppe-Seyler 1990;371(7):567-73.
1989: B Redecker; M Horst; Andrej Hasilik
Calcitriol enhances transcriptional activity of lysozyme and cathepsin D genes in U937 promonocytes.
The Biochemical journal 1989;262(3):843-7.
1989: Susanne Grässel; A Röling; Andrej Hasilik
Immunoprecipitation of labeled antigens with Eupergit C1Z.
Analytical biochemistry 1989;180(1):72-8.
1989: J Cully; B Harrach; H Hauser; N Harth; Horst Robenek; S Nagata; Andrej Hasilik
Synthesis and localization of myeloperoxidase protein in transfected BHK cells.
Experimental cell research 1989;180(2):440-50.
1988: H Eckardt; I Filipovic; Andrej Hasilik; E Buddecke
Calmodulin antagonists increase the amount of mRNA for the low-density-lipoprotein receptor in skin fibroblasts.
The Biochemical journal 1988;252(3):889-92.
1988: Thomas Braulke; M Stein; Thorsten Marquardt; C Gartung; Andrej Hasilik; Kurt von Figura
Receptor-dependent transport of lysosomal enzymes.
Indian journal of biochemistry & biophysics 1988;25(1-2):95-101.
1987: G Lorkowski; J E Zijderhand-Bleekemolen; Ervin G. Erdoes; Kurt von Figura; Andrej Hasilik
Neutral endopeptidase-24.11 (enkephalinase). Biosynthesis and localization in human fibroblasts.
The Biochemical journal 1987;248(2):345-50.
1987: Thorsten Marquardt; Thomas Braulke; Andrej Hasilik; Kurt von Figura
Association of the precursor of cathepsin D with coated membranes. Kinetics and carbohydrate processing.
European journal of biochemistry / FEBS 1987;168(1):37-42.
1987: M Stein; J E Zijderhand-Bleekemolen; H Geuze; Andrej Hasilik; Kurt von Figura
Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes.
The EMBO journal 1987;6(9):2677-81.
1987: M Stein; Thomas Braulke; C Krentler; Andrej Hasilik; Kurt von Figura
46-kDa mannose 6-phosphate-specific receptor: biosynthesis, processing, subcellular location and topology.
Biological chemistry Hoppe-Seyler 1987;368(8):937-47.
1987: M Stein; H E Meyer; Andrej Hasilik; Kurt von Figura
46-kDa mannose 6-phosphate-specific receptor: purification, subunit composition, chemical modification.
Biological chemistry Hoppe-Seyler 1987;368(8):927-36.
1987: Thomas Braulke; C Gartung; Andrej Hasilik; Kurt von Figura
Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?
The Journal of cell biology 1987;104(6):1735-42.
1987: J T Conary; G Lorkowski; Bernhard Schmidt; Regina Pohlmann; G Nagel; H E Meyer; C Krentler; J Cully; Andrej Hasilik; Kurt von Figura
Genetic heterogeneity of steroid sulfatase deficiency revealed with cDNA for human steroid sulfatase.
Biochemical and biophysical research communications 1987;144(2):1010-7.
1986: C Krentler; Regina Pohlmann; Andrej Hasilik; Kurt von Figura
Lysosomal membrane proteins do not bind to mannose-6-phosphate-specific receptors.
Biological chemistry Hoppe-Seyler 1986;367(2):141-5.
1985: C Gartung; Thomas Braulke; Andrej Hasilik; Kurt von Figura
Internalization of blocking antibodies against mannose-6-phosphate specific receptors.
The EMBO journal 1985;4(7):1725-30.