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Per-Olof Hasselgren

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Zaira Aversa; Estibaliz Castillero; Maurizio Muscaritoli; Filippo Rossi-Fanelli; Nima Alamdari; Per-Olof Hasselgren
CaMKII activity is reduced in skeletal muscle during sepsis.
Aaron M Cypess; Laura N Deschamps; Alina Gavrila; Allison L Glasgow; Per-Olof Hasselgren; Lindsay M Herder; Ashley R Holman; Tian Liang Huang; Michael Molla; Marcelo A Mori; Carla Roberts-Toler; Christina A Sass; Tim J Schulz; Cathy Sze; Nathan Truchan; Cecile VERNOCHET; Lauren S Weiner; Andrew P White; Ruidan Xue; Aron T Chacko; Yu-Hua Tseng
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.
Estibaliz Castillero; Aniket Gurav; Nima Alamdari; Zaira Aversa; Per-Olof Hasselgren
PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting.

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2013: Zaira Aversa; Estibaliz Castillero; Maurizio Muscaritoli; Filippo Rossi-Fanelli; Nima Alamdari; Per-Olof Hasselgren
CaMKII activity is reduced in skeletal muscle during sepsis.
Journal of cellular biochemistry 2013;114(6):1294-305.
2013: Aaron M Cypess; Laura N Deschamps; Alina Gavrila; Allison L Glasgow; Per-Olof Hasselgren; Lindsay M Herder; Ashley R Holman; Tian Liang Huang; Michael Molla; Marcelo A Mori; Carla Roberts-Toler; Christina A Sass; Tim J Schulz; Cathy Sze; Nathan Truchan; Cecile VERNOCHET; Lauren S Weiner; Andrew P White; Ruidan Xue; Aron T Chacko; Yu-Hua Tseng
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.
Nature medicine 2013;19(5):635-9.
2013: Estibaliz Castillero; Aniket Gurav; Nima Alamdari; Zaira Aversa; Per-Olof Hasselgren
PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting.
PloS one 2013;8(3):e59726.
2013: Nima Alamdari; Zaira Aversa; Estibaliz Castillero; Per-Olof Hasselgren
Acetylation and deacetylation--novel factors in muscle wasting.
Metabolism: clinical and experimental 2013;62(1):1-11.
2012: Nima Alamdari; Zaira Aversa; Estibaliz Castillero; Ravi Jasuja; Lars Larsson; Rizwan Qaisar; Guillaume Renaud; Ira Smith; Gianluca Toraldo; Per-Olof Hasselgren
Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;303(10):R1090-9.
2012: Zaira Aversa; Estibaliz Castillero; Maurizio Muscaritoli; Filippo Rossi-Fanelli; Nima Alamdari; Per-Olof Hasselgren
β-Hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy.
Biochemical and biophysical research communications 2012;423(4):739-43.
2012: Wei Chamberlain; Patricia Gonnella; Nima Alamdari; Zaira Aversa; Per-Olof Hasselgren
Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2012;90(2):200-8.
2012: Nima Alamdari; Per-Olof Hasselgren
Comment on Sirtuin 1 in skeletal muscle of cachectic tumour-bearing rats.
Journal of cachexia, sarcopenia and muscle 2012;3(1):71-2.
2012: Nima Alamdari; Zaira Aversa; Estibaliz Castillero; Aniket Gurav; Victoria Petkova; Steven Tizio; Per-Olof Hasselgren
Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism.
Biochemical and biophysical research communications 2012;417(1):528-33.
2011: Patrick O'Neal; Peter Mowschenson; James Connolly; Per-Olof Hasselgren
Large parathyroid tumors have an increased risk of atypia and carcinoma.
American journal of surgery 2011;202(2):146-50.
2011: Patricia Gonnella; Nima Alamdari; Zaira Aversa; Victoria Petkova; Steven Tizio; Per-Olof Hasselgren
C/EBPβ regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1.
Journal of cellular biochemistry 2011;112(7):1737-48.
2011: Zaira Aversa; Nima Alamdari; Per-Olof Hasselgren
Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness.
Critical reviews in clinical laboratory sciences 2011;48(2):71-86.
2011: Ira J Smith; Zaira Aversa; Per-Olof Hasselgren; Fabio Pacelli; Fausto Rosa; Giovan Battista Doglietto; Maurizio Bossola
Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss.
Muscle & nerve 2011;43(3):410-4.
2010: Ira J Smith; Zaira Aversa; Nima Alamdari; Victoria Petkova; Per-Olof Hasselgren
Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle.
Journal of cellular biochemistry 2010;111(4):1059-73.
2010: Michael Menconi; Zoltan P Arany; Nima Alamdari; Zaira Aversa; Patricia Gonnella; Patrick O'Neal; Ira J Smith; Steven Tizio; Per-Olof Hasselgren
Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2010;299(4):E533-43.
2010: Nima Alamdari; Ira J Smith; Zaira Aversa; Per-Olof Hasselgren
Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(2):R509-20.
2010: Per-Olof Hasselgren; Nima Alamdari; Zaira Aversa; Patricia Gonnella; Ira J Smith; Steven Tizio
Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation.
Current opinion in clinical nutrition and metabolic care 2010;13(4):423-8.
2010: Ira J Smith; Nima Alamdari; Patrick O'Neal; Patricia Gonnella; Zaira Aversa; Per-Olof Hasselgren
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism.
The international journal of biochemistry & cell biology 2010;42(5):701-11.
2009: Patrick O'Neal; Nima Alamdari; Ira Smith; Vitaliy Poylin; Michael Menconi; Per-Olof Hasselgren
Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle.
Journal of cellular biochemistry 2009;108(4):963-73.
2009: Patrick B O'Neal; Vitaliy Poylin; Peter Mowschenson; Sareh Parangi; Gary Horowitz; Pravin Pant; Per-Olof Hasselgren
When initial postexcision PTH level does not fall appropriately during parathyroidectomy: what to do next?
World journal of surgery 2009;33(8):1665-73.
2009: Melanie Goldfarb; Patrick O'Neal; Judy L Shih; Pamela Hartzband; James Connolly; Per-Olof Hasselgren
Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2009;15(5):463-8.
2009: Nima Alamdari; Patrick O'Neal; Per-Olof Hasselgren
Curcumin and muscle wasting: a new role for an old drug?
Nutrition (Burbank, Los Angeles County, Calif.) 2009;25(2):125-9.
2008: Michael Menconi; Patricia Gonnella; Victoria Petkova; Stewart Lecker; Per-Olof Hasselgren
Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes.
Journal of cellular biochemistry 2008;105(2):353-64.
2008: Ira J Smith; Stewart H Lecker; Per-Olof Hasselgren
Calpain activity and muscle wasting in sepsis.
American journal of physiology. Endocrinology and metabolism 2008;295(4):E762-71.
2008: Vitaliy Poylin; Moin U Fareed; Patrick O'Neal; Nima Alamdari; Natasha Reilly; Michael Menconi; Per-Olof Hasselgren
The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis.
Mediators of inflammation 2008;2008():317851.
2007: Per-Olof Hasselgren
Ubiquitination, phosphorylation, and acetylation--triple threat in muscle wasting.
Journal of cellular physiology 2007;213(3):679-89.
2007: Cheng-Hui Fang; Bingguo Li; J Howard James; Ayesha Yahya; Nijiati Kadeer; Xialing Guo; Chun Xiao; Dorothy M Supp; Richard J Kagan; Per-Olof Hasselgren; Sulaiman Sheriff
GSK-3beta activity is increased in skeletal muscle after burn injury in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(4):R1545-51.
2007: Michael Menconi; Moin U Fareed; Patrick O'Neal; Vitaliy Poylin; Wei Wei; Per-Olof Hasselgren
Role of glucocorticoids in the molecular regulation of muscle wasting.
Critical care medicine 2007;35(9 Suppl):S602-8.
2007: Natasha Reilly; Vitaliy Poylin; Michael Menconi; Andrew B Onderdonk; Stig Bengmark; Per-Olof Hasselgren
Probiotics potentiate IL-6 production in IL-1beta-treated Caco-2 cells through a heat shock-dependent mechanism.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1169-79.
2007: Amy R Evenson; Peter Mowschenson; Helen Wang; James Connolly; Savvas Mendrinos; Sareh Parangi; Per-Olof Hasselgren
Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma.
American journal of surgery 2007;193(6):707-12.
2007: Wei Wei; Hongmei Yang; Michael Menconi; Peirang Cao; Chester E Chamberlain; Per-Olof Hasselgren
Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta.
American journal of physiology. Cell physiology 2007;292(1):C216-26.
2007: Hongmei Yang; Wei Wei; Michael Menconi; Per-Olof Hasselgren
Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(1):R337-4.
2006: Amy R Evenson; Jamie Mitchell; Wei Wei; Vitaliy Poylin; Sareh Parangi; Per-Olof Hasselgren
The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism.
International journal of molecular medicine 2006;18(3):471-5.
2006: Wei Wei; Hongmei Yang; Peirang Cao; Michael Menconi; Chester Chamberlain; Victoria Petkova; Per-Olof Hasselgren
Degradation of C/EBPbeta in cultured myotubes is calpain-dependent.
Journal of cellular physiology 2006;208(2):386-98.
2006: Moin U Fareed; Amy R Evenson; Wei Wei; Michael Menconi; Vitaliy Poylin; Victoria Petkova; Bernadette Pignol; Per-Olof Hasselgren
Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(6):R1589-97.
2005: Jamie C Mitchell; Frederick Grant; Amy R Evenson; J A Parker; Per-Olof Hasselgren; Sareh Parangi
Preoperative evaluation of thyroid nodules with 18FDG-PET/CT.
Surgery 2005;138(6):1166-74; discussion 1174-5.
2005: Per-Olof Hasselgren; Michael Menconi; Moin U Fareed; Hongmei Yang; Wei Wei; Amy R Evenson
Novel aspects on the regulation of muscle wasting in sepsis.
The international journal of biochemistry & cell biology 2005;37(10):2156-68.
2005: Amy R Evenson; Moin U Fareed; Michael Menconi; Jamie C Mitchell; Per-Olof Hasselgren
GSK-3beta inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes.
The international journal of biochemistry & cell biology 2005;37(10):2226-38.
2005: Bing-Guo Li; Per-Olof Hasselgren; Cheng-Hui Fang
Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms.
The international journal of biochemistry & cell biology 2005;37(10):2207-16.
2005: Cheng-Hui Fang; Bing-Guo Li; J Howard James; Jy-Kung King; Amy R Evenson; Glenn D Warden; Per-Olof Hasselgren
Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors.
Endocrinology 2005;146(7):3141-9.
2005: Hongmei Yang; Joshua M V Mammen; Wei Wei; Michael Menconi; Amy R Evenson; Moin U Fareed; Victoria Petkova; Per-Olof Hasselgren
Expression and activity of C/EBPbeta and delta are upregulated by dexamethasone in skeletal muscle.
Journal of cellular physiology 2005;204(1):219-26.
2005: Hongmei Yang; Michael Menconi; Wei Wei; Victoria Petkova; Per-Olof Hasselgren
Dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with C/EBPbeta in cultured myotubes.
Journal of cellular biochemistry 2005;94(5):1058-67.
2005: Wei Wei; Moin U Fareed; Amy R Evenson; Michael Menconi; Hongmei Yang; Victoria Petkova; Per-Olof Hasselgren
Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(3):R580-90.
2004: Dongsheng Cai; J Daniel Frantz; Nicholas E Tawa; Peter A Melendez; Byung-Chul Oh; Hart G W Lidov; Per-Olof Hasselgren; Walter R Frontera; Jongsoon Lee; David J Glass; Steven E Shoelson
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Cell 2004;119(2):285-98.
2004: Michael Menconi; Wei Wei; Hongmei Yang; Curtis J Wray; Per-Olof Hasselgren
Treatment of cultured myotubes with the calcium ionophore A23187 increases proteasome activity via a CaMK II-caspase-calpain-dependent mechanism.
Surgery 2004;136(2):135-42.
2004: Dan D Hershko; Bruce W Robb; Curtis J Wray; Guang-Ju Luo; Per-Olof Hasselgren
Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells.
Journal of cellular biochemistry 2004;91(5):951-61.
2004: Bing-Guo Li; Per-Olof Hasselgren; Cheng-Hui Fang; Glenn D Warden
Insulin-like growth factor-I blocks dexamethasone-induced protein degradation in cultured myotubes by inhibiting multiple proteolytic pathways: 2002 ABA paper.
The Journal of burn care & rehabilitation 2004;25(1):112-8.
2004: Per-Olof Hasselgren
Surgery in Sweden at the time of Halsted.
Archives of surgery (Chicago, Ill. : 1960) 2004;139(1):100-12.
2003: Dan D Hershko; Bruce W Robb; Guang-Ju Luo; Eric S Hungness; Per-Olof Hasselgren
Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha.
Journal of cellular biochemistry 2003;90(3):627-40.
2003: Xiaoyan Sun; Curtis J Wray; Xintian Tian; Per-Olof Hasselgren; James Lu
Expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E512-20.
2003: Guangjo Luo; Dan D Hershko; Bruce W Robb; Curtis J Wray; Per-Olof Hasselgren
IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(5):R1249-54.
2003: Curtis J Wray; Joshua M V Mammen; Dan D Hershko; Per-Olof Hasselgren
Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle.
The international journal of biochemistry & cell biology 2003;35(5):698-705.
2003: Dan D Hershko; Bruce W Robb; Guang-Ju Luo; James H Paxton; Per-Olof Hasselgren
Interleukin-6 induces thermotolerance in cultured Caco-2 cells independent of the heat shock response.
Cytokine 2003;21(1):1-9.
2002: Eric S Hungness; Bruce W Robb; Guang-Ju Luo; Dan D Hershko; Per-Olof Hasselgren
Hyperthermia-induced heat shock activates the transcription factor c/EBP-beta and augments IL-6 production in human intestinal epithelial cells.
Journal of the American College of Surgeons 2002;195(5):619-26.
2002: Curtis J Wray; Joshua M V Mammen; Per-Olof Hasselgren
Catabolic response to stress and potential benefits of nutrition support.
Nutrition (Burbank, Los Angeles County, Calif.) 2002;18(11-12):971-7.
2002: Dan D Hershko; Bruce W Robb; Guangju Luo; Per-Olof Hasselgren
Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(5):R1140-8.
2002: Dan D Hershko; Bruce W Robb; Eric S Hungness; Guangju Luo; Xialing Guo; Per-Olof Hasselgren
Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity.
Clinical science (London, England : 1979) 2002;103(4):381-90.
2002: Cheng-Hui Fang; Bing-Guo Li; Curtis J Wray; Per-Olof Hasselgren
Insulin-like growth factor-I inhibits lysosomal and proteasome-dependent proteolysis in skeletal muscle after burn injury.
The Journal of burn care & rehabilitation 2002;23(5):318-25.
2002: Curtis J Wray; Birgitta Tomkinson; Bruce W Robb; Per-Olof Hasselgren
Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis.
Biochemical and biophysical research communications 2002;296(1):41-7.
2002: Bruce W Robb; Dan D Hershko; James H Paxton; Guang-Ju Luo; Per-Olof Hasselgren
Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells.
Surgery 2002;132(2):226-31.
2002: Eric S Hungness; Guang-Ju Luo; Timothy A Pritts; Xiaoyan Sun; Bruce W Robb; Dan D Hershko; Per-Olof Hasselgren
Transcription factors C/EBP-beta and -delta regulate IL-6 production in IL-1beta-stimulated human enterocytes.
Journal of cellular physiology 2002;192(1):64-70.
2002: Timothy A Pritts; Quan Wang; Xiaoyan Sun; David R Fischer; Eric S Hungness; Josef E Fischer; Hector R Wong; Per-Olof Hasselgren
The stress response decreases NF-kappaB activation in liver of endotoxemic mice.
Shock (Augusta, Ga.) 2002;18(1):33-7.
2002: Eric S Hungness; Bruce W Robb; Connie S Seeskin; Per-Olof Hasselgren; Fred A Luchette
Early debridement for necrotizing pancreatitis: is it worthwhile?
Journal of the American College of Surgeons 2002;194(6):740-4; discussion 744-5.
2002: Hikmat Al-Ahmadie; Per-Olof Hasselgren; Rawia Yassin; George K Mutema
Colocalized granular cell tumor and infiltrating ductal carcinoma of the breast.
Archives of pathology & laboratory medicine 2002;126(6):731-3.
2002: Curtis J Wray; Xiaoyan Sun; Gyu I Gang; Per-Olof Hasselgren
Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle.
The Journal of surgical research 2002;104(2):82-7.
2002: Malek Safal; Elyse E Lower; Per-Olof Hasselgren; Eric S Hungness; Paula Gazder; Bernard S Aron; Elizabeth A Shaughnessy; Rawia Yassin
Bilateral synchronous breast cancer and HER-2/neu overexpression.
Breast cancer research and treatment 2002;72(3):195-201.
2002: Timothy A Pritts; Eric S Hungness; Quan Wang; Bruce W Robb; Dan D Hershko; Per-Olof Hasselgren
Mucosal and enterocyte IL-6 production during sepsis and endotoxemia--role of transcription factors and regulation by the stress response.
American journal of surgery 2002;183(4):372-83.
2002: Per-Olof Hasselgren; Richard G Azizkhan; Robert H Bower; James M Hurst; John J McDonough; Henry W Neale; Glenn D Warden
Festschrift for Josef E. Fischer, MD.
American journal of surgery 2002;183(4):325-492.
2002: Timothy A Pritts; Eric S Hungness; Dan D Hershko; Bruce W Robb; Xiaoyan Sun; Guang-Ju Luo; Josef E Fischer; Hector R Wong; Per-Olof Hasselgren
Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(4):R1016-26.
2002: Eric S Hungness; Timothy A Pritts; Guang-Ju Luo; Dan D Hershko; Bruce W Robb; Per-Olof Hasselgren
IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway.
The international journal of biochemistry & cell biology 2002;34(4):382-95.
2002: David P O'Brien; Lindsey A Nelson; Christopher Kemp; Jodi L Williams; Quan Wang; Christopher R Erwin; Per-Olof Hasselgren; Brad W Warner
Intestinal permeability and bacterial translocation are uncoupled after small bowel resection.
Journal of pediatric surgery 2002;37(3):390-4.
2002: Quan Wang; Per-Olof Hasselgren
Heat shock response reduces intestinal permeability in septic mice: potential role of interleukin-10.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R669-76.
2002: Xiaoyan Sun; David R Fischer; Timothy A Pritts; Curtis J Wray; Per-Olof Hasselgren
Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(2):R509-18.
2002: Gail Penner; Gyu I Gang; Xiaoyan Sun; Curtis J Wray; Per-Olof Hasselgren
C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(2):R439-44.
2002: Eric S Hungness; Bruce W Robb; Guang-Ju Luo; Timothy A Pritts; Dan D Hershko; Per-Olof Hasselgren
Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells.
Biochemical and biophysical research communications 2002;290(1):469-74.
2002: Per-Olof Hasselgren; Curtis J Wray; Joshua M V Mammen
Molecular regulation of muscle cachexia: it may be more than the proteasome.
Biochemical and biophysical research communications 2002;290(1):1-10.
2002: Dan D Hershko; Bruce W Robb; Eric S Hungness; Guangju Luo; Per-Olof Hasselgren
Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response.
Journal of cellular biochemistry 2002;84(4):687-98.
2001: G Luo; Xiaoyan Sun; Eric S Hungness; Per-Olof Hasselgren
Heat shock protects L6 myotubes from catabolic effects of dexamethasone and prevents downregulation of NF-kappaB.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(4):R1193-200.
2001: David P O'Brien; Lindsey A Nelson; LE Stern; Jodi L Williams; Christopher Kemp; Q Wang; P Tso; Christopher R Erwin; Per-Olof Hasselgren; Brad W Warner
Epithelial permeability is not increased in rats following small bowel resection.
The Journal of surgical research 2001;97(1):65-70.
2001: C Gail Penner; Gyu I Gang; Curtis J Wray; Josef E Fischer; Per-Olof Hasselgren
The transcription factors NF-kappab and AP-1 are differentially regulated in skeletal muscle during sepsis.
Biochemical and biophysical research communications 2001;281(5):1331-6.
2001: David R Fischer; Xiaoyan Sun; A B Williams; Gyu I Gang; Timothy A Pritts; J Howard James; M Molloy; Josef E Fischer; Richard J Paul; Per-Olof Hasselgren
Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats.
Shock (Augusta, Ga.) 2001;15(3):200-7.
2001: Per-Olof Hasselgren; Josef E Fischer
Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation.
Annals of surgery 2001;233(1):9-17.
2000: Per-Olof Hasselgren
Catabolic response to stress and injury: implications for regulation.
World journal of surgery 2000;24(12):1452-9.
2000: C H Fang; Xiaoyan Sun; B G Li; David R Fischer; Timothy A Pritts; G Penner; Per-Olof Hasselgren
Burn injuries in rats upregulate the gene expression of the ubiquitin-conjugating enzyme E2(14k) in skeletal muscle.
The Journal of burn care & rehabilitation 2000;21(6):528-34.
2000: Eric S Hungness; Malek Safa; Elizabeth A Shaughnessy; Bernard S Aron; Paula Gazder; HH Hawkins; Elyse E Lower; Connie S Seeskin; Rawia Yassin; Per-Olof Hasselgren
Bilateral synchronous breast cancer: mode of detection and comparison of histologic features between the 2 breasts.
Surgery 2000;128(4):702-7.
2000: C H Fang; B G Li; David R Fischer; J J Wang; Herbert A Runnels; John J Monaco; Per-Olof Hasselgren
Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle.
Clinical science (London, England : 1979) 2000;99(3):181-7.
2000: Eric S Hungness; Timothy A Pritts; Guang-Ju Luo; Xiaoyan Sun; C Gail Penner; Per-Olof Hasselgren
The transcription factor activator protein-1 is activated and interleukin-6 production is increased in interleukin-1beta-stimulated human enterocytes.
Shock (Augusta, Ga.) 2000;14(3):386-91.
2000: Timothy A Pritts; MR Moon; Quan Wang; Eric S Hungness; AL Salzman; Josef E Fischer; Per-Olof Hasselgren
Activation of NF-kappaB varies in different regions of the gastrointestinal tract during endotoxemia.
Shock (Augusta, Ga.) 2000;14(2):118-22.
2000: Cheng-Hui Fang; Bing-Guo Li; Xiaoyan Sun; Per-Olof Hasselgren
Insulin-like growth factor I reduces ubiquitin and ubiquitin-conjugating enzyme gene expression but does not inhibit muscle proteolysis in septic rats.
Endocrinology 2000;141(8):2743-51.
2000: Timothy A Pritts; Quan Wang; Xiaoyan Sun; MR Moon; David R Fischer; Josef E Fischer; Hector R Wong; Per-Olof Hasselgren
Induction of the stress response in vivo decreases nuclear factor-kappa B activity in jejunal mucosa of endotoxemic mice.
Archives of surgery (Chicago, Ill. : 1960) 2000;135(7):860-6.
2000: Bing-Guo Li; C H Fang; Per-Olof Hasselgren
Degradation of methoxysuccinyl-phe-leu-phe-7-amido-4-trifluoromethyl coumarin (FLF) in cultured myotubes and HepG2 cells is proteasome- and calpain/calcium-dependent.
The international journal of biochemistry & cell biology 2000;32(6):677-86.
2000: MR Moon; AA Parikh; Timothy A Pritts; C Kane; Josef E Fischer; AL Salzman; Per-Olof Hasselgren
Interleukin-1beta induces complement component C3 and IL-6 production at the basolateral and apical membranes in a human intestinal epithelial cell line.
Shock (Augusta, Ga.) 2000;13(5):374-8.
2000: D Fischer; Gyu I Gang; Timothy A Pritts; Per-Olof Hasselgren
Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo.
Biochemical and biophysical research communications 2000;270(1):215-21.
2000: Guang-Ju Luo; Xiaoyan Sun; Per-Olof Hasselgren
Hyperthermia stimulates energy-proteasome-dependent protein degradation in cultured myotubes.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(3):R749-56.
2000: D Fischer; Xiaoyan Sun; Gyu I Gang; Timothy A Pritts; Per-Olof Hasselgren
The gene expression of ubiquitin ligase E3alpha is upregulated in skeletal muscle during sepsis in rats-potential role of glucocorticoids.
Biochemical and biophysical research communications 2000;267(2):504-8.
2000: AA Parikh; MR Moon; Timothy A Pritts; Josef E Fischer; Csaba Szabó; Per-Olof Hasselgren; AL Salzman
IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling.
Shock (Augusta, Ga.) 2000;13(1):8-13.
1999: A Williams; Xiaoyan Sun; Josef E Fischer; Per-Olof Hasselgren
The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer.
Surgery 1999;126(4):744-9; discussion 749-50.
1999: R Moon; Timothy A Pritts; AA Parikh; Josef E Fischer; AL Salzman; M Ryan; Hector R Wong; Per-Olof Hasselgren
Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells.
Clinical science (London, England : 1979) 1999;97(3):331-7.
1999: SC Hobler; A Williams; D Fischer; JJ Wang; Xiaoyan Sun; Josef E Fischer; John J Monaco; Per-Olof Hasselgren
Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis.
The American journal of physiology 1999;277(2 Pt 2):R434-40.
1999: A B Williams; Gabrielle DeCourten-Myers; J E Fischer; G Luo; X Sun; Per-Olof Hasselgren
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(11):1435-43.
1999: Per-Olof Hasselgren
Glucocorticoids and muscle catabolism.
Current opinion in clinical nutrition and metabolic care 1999;2(3):201-5.
1999: M Molloy; Robert H Bower; Per-Olof Hasselgren; B J Dalton
Cholangiography during laparoscopic cholecystectomy--cumulative sum analysis of an institutional learning curve.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(2):185-8.
1999: Per-Olof Hasselgren
Pathways of muscle protein breakdown in injury and sepsis.
Current opinion in clinical nutrition and metabolic care 1999;2(2):155-60.
1999: MR Moon; AA Parikh; Timothy A Pritts; Josef E Fischer; S Cottongim; Csaba Szabó; AL Salzman; Per-Olof Hasselgren
Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha.
The Journal of surgical research 1999;82(1):48-55.
1999: Per-Olof Hasselgren
Burns and metabolism.
Journal of the American College of Surgeons 1999;188(2):98-103.
1999: SC Hobler; JJ Wang; A B Williams; F Melandri; Xiaoyan Sun; Josef E Fischer; Per-Olof Hasselgren
Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle.
The American journal of physiology 1999;276(2 Pt 2):R468-73.
1999: Per-Olof Hasselgren; J E Fischer
Counter-regulatory hormones and mechanisms in amino acid metabolism with special reference to the catabolic response in skeletal muscle.
Current opinion in clinical nutrition and metabolic care 1999;2(1):9-14.
1999: M Molloy; M J Sorrell; Robert H Bower; Per-Olof Hasselgren; B J Dalton
Patterns of morbidity and resource consumption associated with laparoscopic cholecystectomy in a VA medical center.
The Journal of surgical research 1999;81(1):15-20.
1998: Timothy A Pritts; R Moon; Josef E Fischer; AL Salzman; Per-Olof Hasselgren
Nuclear factor-kappaB is activated in intestinal mucosa during endotoxemia.
Archives of surgery (Chicago, Ill. : 1960) 1998;133(12):1311-5.
1998: A Williams; JJ Wang; L Wang; Xiaoyan Sun; Josef E Fischer; Per-Olof Hasselgren
Sepsis in mice stimulates muscle proteolysis in the absence of IL-6.
The American journal of physiology 1998;275(6 Pt 2):R1983-91.
1998: Quan Wang; JJ Wang; Josef E Fischer; Per-Olof Hasselgren
Mucosal production of complement C3 and serum amyloid A is differentially regulated in different parts of the gastrointestinal tract during endotoxemia in mice.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1998;2(6):537-46.
1998: Quan Wang; TA Meyer; Steven T Boyce; JJ Wang; Xiaoyan Sun; Greg Tiao; Josef E Fischer; Per-Olof Hasselgren
Endotoxemia in mice stimulates production of complement C3 and serum amyloid A in mucosa of small intestine.
The American journal of physiology 1998;275(5 Pt 2):R1584-92.
1998: L Wang; Guang-Ju Luo; JJ Wang; Per-Olof Hasselgren
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Shock (Augusta, Ga.) 1998;10(4):298-306.
1998: C H Fang; B G Li; JJ Wang; Josef E Fischer; Per-Olof Hasselgren
Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle.
The American journal of physiology 1998;275(4 Pt 2):R1091-8.
1998: C H Fang; JJ Wang; SC Hobler; B G Li; Josef E Fischer; Per-Olof Hasselgren
Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats.
Clinical science (London, England : 1979) 1998;95(2):225-33.
1998: AA Parikh; MR Moon; CD Kane; AL Salzman; Josef E Fischer; Per-Olof Hasselgren
Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response.
The Journal of surgical research 1998;77(1):40-4.
1998: Cheng-Hui Fang; Bing-Guo Li; J Howard James; Josef E Fischer; Per-Olof Hasselgren
The anabolic effects of IGF-1 in skeletal muscle after burn injury are not caused by increased cell volume.
JPEN. Journal of parenteral and enteral nutrition 1998;22(3):115-9.
1998: Quan Wang; JJ Wang; S Boyce; Josef E Fischer; Per-Olof Hasselgren
Endotoxemia and IL-1 beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract.
The Journal of surgical research 1998;76(1):27-31.
1998: SC Hobler; A B Williams; Josef E Fischer; Per-Olof Hasselgren
IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats.
The American journal of physiology 1998;274(2 Pt 2):R571-6.
1998: Per-Olof Hasselgren; J E Fischer
Sepsis: stimulation of energy-dependent protein breakdown resulting in protein loss in skeletal muscle.
World journal of surgery 1998;22(2):203-8.
1998: C H Fang; B G Li; Greg Tiao; JJ Wang; Josef E Fischer; Per-Olof Hasselgren
The molecular regulation of protein breakdown following burn injury is different in fast- and slow-twitch skeletal muscle.
International journal of molecular medicine 1998;1(1):163-9.
1998: SC Hobler; Greg Tiao; Josef E Fischer; John J Monaco; Per-Olof Hasselgren
Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors.
The American journal of physiology 1998;274(1 Pt 2):R30-7.
1997: R Moon; AA Parikh; Csaba Szabó; Josef E Fischer; AL Salzman; Per-Olof Hasselgren
Complement C3 production in human intestinal epithelial cells is regulated by interleukin 1beta and tumor necrosis factor alpha.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(12):1289-93.
1997: Cheng-Hui Fang; Bing-Guo Li; J Howard James; Josef E Fischer; Per-Olof Hasselgren
Cytokines block the effects of insulin-like growth factor-I (IGF-I) on glucose uptake and lactate production in skeletal muscle but do not influence IGF-I-induced changes in protein turnover.
Shock (Augusta, Ga.) 1997;8(5):362-7.
1997: AA Parikh; AL Salzman; Josef E Fischer; Csaba Szabó; Per-Olof Hasselgren
Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells.
Shock (Augusta, Ga.) 1997;8(4):249-55.
1997: Cheng-Hui Fang; Bing-Guo Li; J J Wang; Josef E Fischer; Per-Olof Hasselgren
Insulin-like growth factor 1 stimulates protein synthesis and inhibits protein breakdown in muscle from burned rats.
JPEN. Journal of parenteral and enteral nutrition 1997;21(5):245-51.
1997: TA Meyer; JJ Wang; Greg Tiao; C K Ogle; Josef E Fischer; Per-Olof Hasselgren
Sepsis and endotoxaemia in mice stimulate the expression of interleukin-I and interleukin-6 in the central nervous system.
Clinical science (London, England : 1979) 1997;92(5):519-25.
1997: AA Parikh; AL Salzman; CD Kane; Josef E Fischer; Per-Olof Hasselgren
IL-6 production in human intestinal epithelial cells following stimulation with IL-1 beta is associated with activation of the transcription factor NF-kappa B.
The Journal of surgical research 1997;69(1):139-44.
1997: Y Noguchi; J Howard James; Josef E Fischer; Per-Olof Hasselgren
Increased glutamine consumption in small intestine epithelial cells during sepsis in rats.
American journal of surgery 1997;173(3):199-205.
1997: Greg Tiao; M Lieberman; Josef E Fischer; Per-Olof Hasselgren
Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle.
The American journal of physiology 1997;272(3 Pt 2):R849-56.
1997: Per-Olof Hasselgren; Josef E Fischer
The ubiquitin-proteasome pathway: review of a novel intracellular mechanism of muscle protein breakdown during sepsis and other catabolic conditions.
Annals of surgery 1997;225(3):307-16.
1997: Greg Tiao; SC Hobler; JJ Wang; TA Meyer; Fred A Luchette; Josef E Fischer; Per-Olof Hasselgren
Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.
The Journal of clinical investigation 1997;99(2):163-8.
1997: Quan Wang; Josef E Fischer; Per-Olof Hasselgren
Treatment of endotoxemic mice with anti-interleukin-6 antibody paradoxically increases interleukin-6 levels and stimulates mucosal protein synthesis.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(1):82-8.
1996: J M Fagan; M Ganguly; Greg Tiao; J E Fischer; Per-Olof Hasselgren
Sepsis increases oxidatively damaged proteins in skeletal muscle.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(12):1326-31; discussion 1331-2.
1996: J Howard James; Cheng-Hui Fang; S J Schrantz; Per-Olof Hasselgren; Richard J Paul; Josef E Fischer
Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis.
The Journal of clinical investigation 1996;98(10):2388-97.
1996: W J O'Brien; Jerry B Lingrel; Josef E Fischer; Per-Olof Hasselgren
Sepsis increases skeletal muscle sodium, potassium-adenosinetriphosphatase activity without affecting messenger RNA or protein levels.
Journal of the American College of Surgeons 1996;183(5):471-9.
1996: Greg Tiao; K Hudson; M A Lieberman; Josef E Fischer; Per-Olof Hasselgren
Identification of altered gene expression in skeletal muscle during sepsis using differential display.
The Journal of surgical research 1996;64(1):63-7.
1996: Y Noguchi; T Meyer; Greg Tiao; Josef E Fischer; Per-Olof Hasselgren
Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats.
Shock (Augusta, Ga.) 1996;5(5):333-40.
1996: Greg Tiao; J Fagan; V Roegner; M Lieberman; JJ Wang; Josef E Fischer; Per-Olof Hasselgren
Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
The Journal of clinical investigation 1996;97(2):339-48.
1996: Y Noguchi; T A Meyer; Greg Tiao; Cora K Ogle; Josef E Fischer; Per-Olof Hasselgren
Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats.
Metabolism: clinical and experimental 1996;45(1):28-33.
1995: Greg Tiao; Y Noguchi; M A Lieberman; Josef E Fischer; Per-Olof Hasselgren
Sepsis stimulates polyamine biosynthesis in the liver and increases tissue levels of ornithine decarboxylase mRNA.
Shock (Augusta, Ga.) 1995;4(6):403-10.
1995: T Higashiguchi; Y Noguchi; T Meyer; Josef E Fischer; Per-Olof Hasselgren
Protein synthesis in isolated enterocytes from septic or endotoxaemic rats: regulation by glutamine.
Clinical science (London, England : 1979) 1995;89(3):311-9.
1995: T A Meyer; J Wang; Greg Tiao; Cora K Ogle; Josef E Fischer; Per-Olof Hasselgren
Sepsis and endotoxemia stimulate intestinal interleukin-6 production.
Surgery 1995;118(2):336-42.
1995: Cheng-Hui Fang; J Howard James; Josef E Fischer; Per-Olof Hasselgren
Is muscle protein turnover regulated by intracellular glutamine during sepsis?
JPEN. Journal of parenteral and enteral nutrition 1995;19(4):279-85.
1995: T A Meyer; Greg Tiao; J Howard James; Y Noguchi; Cora K Ogle; Josef E Fischer; Per-Olof Hasselgren
Nitric oxide inhibits LPS-induced IL-6 production in enterocytes.
The Journal of surgical research 1995;58(6):570-5.
1995: Cheng-Hui Fang; Greg Tiao; H James; C Ogle; Josef E Fischer; Per-Olof Hasselgren
Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway.
Journal of the American College of Surgeons 1995;180(2):161-70.
1995: Cheng-Hui Fang; H J James; C Ogle; Josef E Fischer; Per-Olof Hasselgren
Influence of burn injury on protein metabolism in different types of skeletal muscle and the role of glucocorticoids.
Journal of the American College of Surgeons 1995;180(1):33-42.
1995: William T Chance; Y Noguchi; X Zhang; Per-Olof Hasselgren; Josef E Fischer
Differential effects of tumor and parenteral nutrition on jejunal mucosal polyamines.
Nutrition and cancer 1995;23(1):23-32.
1994: Greg Tiao; J M Fagan; N Samuels; J Howard James; K Hudson; M Lieberman; Josef E Fischer; Per-Olof Hasselgren
Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.
The Journal of clinical investigation 1994;94(6):2255-64.
1994: T A Meyer; Y Noguchi; Cora K Ogle; Greg Tiao; JJ Wang; Josef E Fischer; Per-Olof Hasselgren
Endotoxin stimulates interleukin-6 production in intestinal epithelial cells. A synergistic effect with prostaglandin E2.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(12):1290-4; discussion 1294-5.
1994: T Higashiguchi; Y Noguchi; Amy Noffsinger; Josef E Fischer; Per-Olof Hasselgren
Sepsis increases production of total secreted proteins, vasoactive intestinal peptide, and peptide YY in isolated rat enterocytes.
American journal of surgery 1994;168(3):251-6.
1994: T Higashiguchi; Y Noguchi; W O'Brien; K Wagner; Josef E Fischer; Per-Olof Hasselgren
Effect of sepsis on mucosal protein synthesis in different parts of the gastrointestinal tract in rats.
Clinical science (London, England : 1979) 1994;87(2):207-11.
1994: Greg Tiao; J Rafferty; C Ogle; Josef E Fischer; Per-Olof Hasselgren
Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6.
Surgery 1994;116(2):332-7; discussion 337-8.
1994: Oded Zamir; W O'Brien; R Thompson; D C Bloedow; Josef E Fischer; Per-Olof Hasselgren
Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist.
The International journal of biochemistry 1994;26(7):943-50.
1993: Per-Olof Hasselgren; R P Hummel; D Georgian-Smith; M Fieler
Breast biopsy with needle localization: accuracy of specimen x-ray and management of missed lesions.
Surgery 1993;114(4):836-40; discussion 840-2.
1993: Oded Zamir; J Howard James; Per-Olof Hasselgren; Josef E Fischer
Evidence that inhibition of muscle amino acid uptake during endotoxemia is not mediated by glucocorticoids.
Metabolism: clinical and experimental 1993;42(9):1190-4.
1993: W O'Brien; Per-Olof Hasselgren; R P Hummel; R Coith; D Hyams; L Kurtzman; Henry W Neale
Comparison of postoperative wound complications and early cancer recurrence between patients undergoing mastectomy with or without immediate breast reconstruction.
American journal of surgery 1993;166(1):1-5.
1993: Oded Zamir; Per-Olof Hasselgren; H James; T Higashiguchi; Josef E Fischer
Effect of tumor necrosis factor or interleukin-1 on muscle amino acid uptake and the role of glucocorticoids.
Surgery, gynecology & obstetrics 1993;177(1):27-32.
1993: T Higashiguchi; Per-Olof Hasselgren; K Wagner; Josef E Fischer
Effect of glutamine on protein synthesis in isolated intestinal epithelial cells.
JPEN. Journal of parenteral and enteral nutrition 1993;17(4):307-14.
1993: J Howard James; Per-Olof Hasselgren; J K King; L E James; Josef E Fischer
Intracellular glutamine concentration does not decrease in all muscles during sepsis.
The Journal of surgical research 1993;54(6):558-64.
1993: Oded Zamir; Per-Olof Hasselgren; Daniel Vonallmen; Josef E Fischer
In vivo administration of interleukin-1 alpha induces muscle proteolysis in normal and adrenalectomized rats.
Metabolism: clinical and experimental 1993;42(2):204-8.
1993: J A Frederick; Per-Olof Hasselgren; S Davis; T Higashiguchi; T D Jacob; Josef E Fischer
Nitric oxide may upregulate in vivo hepatic protein synthesis during endotoxemia.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(2):152-6; discussion 156-7.
1992: Oded Zamir; Per-Olof Hasselgren; J A Frederick; Josef E Fischer
Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats.
Journal of pediatric surgery 1992;27(11):1399-403.
1992: Per-Olof Hasselgren; J P Fidler
Further evidence against the routine use of parathyroid ultrasonography prior to initial neck exploration for hyperparathyroidism.
American journal of surgery 1992;164(4):337-40.
1992: Daniel Vonallmen; Per-Olof Hasselgren; T Higashiguchi; J Frederick; Oded Zamir; Josef E Fischer
Increased intestinal protein synthesis during sepsis and following the administration of tumour necrosis factor alpha or interleukin-1 alpha.
The Biochemical journal 1992;286 ( Pt 2)():585-9.
1992: Daniel Vonallmen; Per-Olof Hasselgren; T Higashiguchi; Josef E Fischer
Individual regulation of different hepatocellular functions during sepsis.
Metabolism: clinical and experimental 1992;41(9):961-9.
1992: Oded Zamir; Per-Olof Hasselgren; W O'Brien; R C Thompson; Josef E Fischer
Muscle protein breakdown during endotoxemia in rats and after treatment with interleukin-1 receptor antagonist (IL-1ra).
Annals of surgery 1992;216(3):381-5; discussion 386-7.
1992: Oded Zamir; Per-Olof Hasselgren; Steven Kunkel; J Frederick; T Higashiguchi; Josef E Fischer
Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1992;127(2):170-4.
1992: Oded Zamir; Per-Olof Hasselgren; T Higashiguchi; J A Frederick; Josef E Fischer
Effect of sepsis or cytokine administration on release of gut peptides.
American journal of surgery 1992;163(1):181-4; discussion 184-5.
1991: U Angerås; M Hall-Angerås; Kenneth R Wagner; H James; Per-Olof Hasselgren; Josef E Fischer
Tissue metabolite levels in different types of skeletal muscle during sepsis.
Metabolism: clinical and experimental 1991;40(11):1147-51.
1991: Oded Zamir; Per-Olof Hasselgren; Daniel Vonallmen; Josef E Fischer
The effect of interleukin-1 alpha and the glucocorticoid receptor blocker RU 38486 on total and myofibrillar protein breakdown in skeletal muscle.
The Journal of surgical research 1991;50(6):579-83.
1991: Daniel Vonallmen; S J Li; Per-Olof Hasselgren; Josef E Fischer
Effect of ischemia on protein synthesis in the septic liver.
Surgery, gynecology & obstetrics 1991;172(6):441-8.
1991: M Hall-Angerås; U Angerås; Oded Zamir; Per-Olof Hasselgren; Josef E Fischer
Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis.
Surgery 1991;109(4):468-73.
1991: M Hall-Angerås; Per-Olof Hasselgren; R V Dimlich; Josef E Fischer
Myofibrillar proteinase, cathepsin B, and protein breakdown rates in skeletal muscle from septic rats.
Metabolism: clinical and experimental 1991;40(3):302-6.
1991: M Hall-Angerås; U Angerås; Daniel Vonallmen; T Higashiguchi; Oded Zamir; Per-Olof Hasselgren; Josef E Fischer
Influence of sepsis in rats on muscle protein turnover in vivo and in tissue incubated under different in vitro conditions.
Metabolism: clinical and experimental 1991;40(3):247-51.
1991: Josef E Fischer; Per-Olof Hasselgren
Cytokines and glucocorticoids in the regulation of the "hepato-skeletal muscle axis" in sepsis.
American journal of surgery 1991;161(2):266-71.
1991: Per-Olof Hasselgren; JV Tricoli; David F Wieczorek; K A Steigerwald; U Angerås; M Hall-Angerås; Josef E Fischer
Reduced levels of mRNA for myofibrillar proteins in skeletal muscle from septic rats.
Life sciences 1991;49(10):753-60.
1991: D T Hiyama; Daniel Vonallmen; L Rosenblum; Cora K Ogle; Per-Olof Hasselgren; Josef E Fischer
Synthesis of albumin and acute-phase proteins in perfused liver after burn injury in rats.
The Journal of burn care & rehabilitation 1991;12(1):1-6.
1990: Per-Olof Hasselgren; Oded Zamir; J Howard James; Josef E Fischer
Prostaglandin E2 does not regulate total or myofibrillar protein breakdown in incubated skeletal muscle from normal or septic rats.
The Biochemical journal 1990;270(1):45-50.
1990: M Hall-Angerås; U Angerås; Oded Zamir; Per-Olof Hasselgren; Josef E Fischer
Interaction between corticosterone and tumor necrosis factor stimulated protein breakdown in rat skeletal muscle, similar to sepsis.
Surgery 1990;108(2):460-6.
1990: Daniel Vonallmen; Per-Olof Hasselgren; Josef E Fischer
Hepatic protein synthesis in a modified septic rat model.
The Journal of surgical research 1990;48(5):476-80.
1990: M Hall-Angerås; U Angerås; Per-Olof Hasselgren; Josef E Fischer
Corticosterone alone does not explain increased muscle proteolysis in septic rats.
The Journal of surgical research 1990;48(4):368-72.
1990: Per-Olof Hasselgren; J Howard James; D W Benson; S Li; Josef E Fischer
Is there a circulating proteolysis-inducing factor during sepsis?
Archives of surgery (Chicago, Ill. : 1960) 1990;125(4):510-4.
1990: M Hall-Angerås; U Angerås; Per-Olof Hasselgren; Josef E Fischer
Effects of elevated temperature on protein breakdown in muscles from septic rats.
The American journal of physiology 1990;258(4 Pt 1):C589-92.
1990: Per-Olof Hasselgren; M Hall-Angerås; U Angerås; D Benson; J Howard James; Josef E Fischer
Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length.
The Biochemical journal 1990;267(1):37-44.
1990: J Howard James; Per-Olof Hasselgren; R P Hummel; Brad W Warner; Josef E Fischer
Effect of sepsis on amino acid transport system A and its response to insulin in incubated rat skeletal muscle.
Metabolism: clinical and experimental 1990;39(4):335-40.
1990: Brad W Warner; Per-Olof Hasselgren; R P Hummel; J Howard James; P Pedersen; Josef E Fischer
Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle.
American journal of surgery 1990;159(3):295-300.
1990: Brad W Warner; Per-Olof Hasselgren; J Howard James; R P Hummel; D F Rigel; Josef E Fischer
Reduced amino acid transport in skeletal muscle caused by a circulating factor during endotoxemia.
Annals of surgery 1990;211(3):323-8.
1989: P Pedersen; Per-Olof Hasselgren; U Angerås; M Hall-Angerås; Brad W Warner; R LaFrance; S Li; Josef E Fischer
Protein synthesis in liver following infusion of the catabolic hormones corticosterone, epinephrine, and glucagon in rats.
Metabolism: clinical and experimental 1989;38(10):927-32.
1989: Brad W Warner; R P Hummel; Per-Olof Hasselgren; J Howard James; Josef E Fischer
Inhibited amino acid uptake in skeletal muscle during starvation.
JPEN. Journal of parenteral and enteral nutrition 1989;13(4):344-8.
1989: D W Benson; Per-Olof Hasselgren; D T Hiyama; J Howard James; S Li; D F Rigel; Josef E Fischer
Effect of sepsis on calcium uptake and content in skeletal muscle and regulation in vitro by calcium of total and myofibrillar protein breakdown in control and septic muscle: results from a preliminary study.
Surgery 1989;106(1):87-93.
1989: Per-Olof Hasselgren; J Howard James; D W Benson; M Hall-Angerås; U Angerås; D T Hiyama; S Li; Josef E Fischer
Total and myofibrillar protein breakdown in different types of rat skeletal muscle: effects of sepsis and regulation by insulin.
Metabolism: clinical and experimental 1989;38(7):634-40.
1989: P V Pedersen; Brad W Warner; H S Bjornson; D T Hiyama; S Li; D F Rigel; Per-Olof Hasselgren; Josef E Fischer
Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats.
Surgery, gynecology & obstetrics 1989;168(2):148-56.
1988: R P Hummel; Per-Olof Hasselgren; J Howard James; Brad W Warner; Josef E Fischer
The effect of sepsis in rats on skeletal muscle protein synthesis in vivo and in periphery and central core of incubated muscle preparations in vitro.
Metabolism: clinical and experimental 1988;37(12):1120-7.
1988: P Pedersen; S J Li; Per-Olof Hasselgren; R LaFrance; Josef E Fischer
Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver.
Annals of surgery 1988;208(6):714-20.
1988: Per-Olof Hasselgren; P Pedersen; H C Sax; Brad W Warner; Josef E Fischer
Methods for studying protein synthesis and degradation in liver and skeletal muscle.
The Journal of surgical research 1988;45(4):389-415.
1988: P Pedersen; Per-Olof Hasselgren; S J Li; D T Hiyama; Josef E Fischer
Synthesis of acute-phase proteins in perfused liver following administration of recombinant interleukin 1 alpha to normal or adrenalectomized rats.
The Journal of surgical research 1988;45(4):333-41.
1988: Per-Olof Hasselgren; P Pedersen; H C Sax; Brad W Warner; Josef E Fischer
Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(8):992-9.
1988: H C Sax; Per-Olof Hasselgren; Mark A Talamini; L L Edwards; Josef E Fischer
Amino acid uptake in isolated, perfused liver: effect of trauma and sepsis.
The Journal of surgical research 1988;45(1):50-5.
1988: R P Hummel; Brad W Warner; J Howard James; Per-Olof Hasselgren; Josef E Fischer
Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis.
The Journal of surgical research 1988;45(1):140-4.
1988: Per-Olof Hasselgren; R LaFrance; P Pedersen; J Howard James; Josef E Fischer
Infusion of a branched-chain amino acid-enriched solution and alpha-ketoisocaproic acid in septic rats: effects on nitrogen balance and skeletal muscle protein turnover.
JPEN. Journal of parenteral and enteral nutrition 1988;12(3):244-9.
1988: Per-Olof Hasselgren; J Howard James; Brad W Warner; R P Hummel; Josef E Fischer
Protein synthesis and degradation in skeletal muscle from septic rats. Response to leucine and alpha-ketoisocaproic acid.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(5):640-4.
1988: Per-Olof Hasselgren; Brad W Warner; R P Hummel; J Howard James; Cora K Ogle; Josef E Fischer
Further evidence that accelerated muscle protein breakdown during sepsis is not mediated by prostaglandin E2.
Annals of surgery 1988;207(4):399-403.
1988: R P Hummel; J Howard James; Brad W Warner; Per-Olof Hasselgren; Josef E Fischer
Evidence that cathepsin B contributes to skeletal muscle protein breakdown during sepsis.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(2):221-4.
1988: H C Sax; Mark A Talamini; Per-Olof Hasselgren; L Rosenblum; Cora K Ogle; Josef E Fischer
Increased synthesis of secreted hepatic proteins during abdominal sepsis.
The Journal of surgical research 1988;44(2):109-16.
1987: T Schröder; Per-Olof Hasselgren; K Brackett; S N Joffe
Techniques of liver resection. Comparison of suction knife, ultrasonic dissector, and contact neodymium-YAG laser.
Archives of surgery (Chicago, Ill. : 1960) 1987;122(10):1166-71.
1987: Brad W Warner; Per-Olof Hasselgren; J Howard James; H Bialkowska; D F Rigel; C Ogle; Josef E Fischer
Superoxide dismutase in rats with sepsis. Effect on survival rate and amino acid transport.
Archives of surgery (Chicago, Ill. : 1960) 1987;122(10):1142-6.
1987: Brad W Warner; J Howard James; Per-Olof Hasselgren; R LaFrance; J E Fischer
Effect of catabolic hormone infusion on organ amino acid uptake.
The Journal of surgical research 1987;42(4):418-24.
1986: Per-Olof Hasselgren; J Howard James; Brad W Warner; C Ogle; H Takehara; Josef E Fischer
Reduced muscle amino acid uptake in sepsis and the effects in vitro of septic plasma and interleukin-1.
Surgery 1986;100(2):222-8.
1985: Per-Olof Hasselgren; Mark A Talamini; R LaFrance; J Howard James; J C Peters; J E Fischer
Effect of indomethacin on proteolysis in septic muscle.
Annals of surgery 1985;202(5):557-62.