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Tomoyo Hasuda

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Tomoyo Hasuda; Yukio Hitotsuyanagi; Mitsuyuki Shinada; Koichi Takeya
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide.
Yukio Hitotsuyanagi; Saori Kato; Jun-ichi Kusano; Masumi Odagiri; Haruhiko Fukaya; Tomoyo Hasuda; Koichi Takeya
Isolation, structure determination, and synthesis of allo-RA-V and neo-RA-V, RA-series bicyclic peptides from Rubia cordifolia L.
Tomoyo Hasuda; Yukio Hitotsuyanagi; Koichi Takeya
Monoclonal antibodies from Rubia cordifolia against antitumor cyclohexapeptide deoxybouvardin and their use in immunoassay.

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2012: Tomoyo Hasuda; Yukio Hitotsuyanagi; Mitsuyuki Shinada; Koichi Takeya
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide.
Bioorganic & medicinal chemistry letters 2012;22(8):2757-9.
2012: Yukio Hitotsuyanagi; Saori Kato; Jun-ichi Kusano; Masumi Odagiri; Haruhiko Fukaya; Tomoyo Hasuda; Koichi Takeya
Isolation, structure determination, and synthesis of allo-RA-V and neo-RA-V, RA-series bicyclic peptides from Rubia cordifolia L.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(10):2839-46.
2012: Tomoyo Hasuda; Yukio Hitotsuyanagi; Koichi Takeya
Monoclonal antibodies from Rubia cordifolia against antitumor cyclohexapeptide deoxybouvardin and their use in immunoassay.
Hybridoma (2005) 2012;31(1):20-4.
2011: Tomoyo Hasuda; Yukio Hitotsuyanagi; Koichi Takeya
Production of monoclonal antibodies against antitumor cyclohexapeptide RA-VII from Rubia cordifolia and their characterization.
Journal of natural medicines 2011;65(3-4):588-93.
2011: Yutaka Aoyagi; Yukio Hitotsuyanagi; Tomoyo Hasuda; Haruhiko Fukaya; Koichi Takeya; Ritsuo Aiyama; Takeshi Matsuzaki; Shusuke Hashimoto
Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities.
Bioorganic & medicinal chemistry letters 2011;21(10):3046-9.
2008: Yutaka Aoyagi; Yukio Hitotsuyanagi; Tomoyo Hasuda; Saki Matsuyama; Haruhiko Fukaya; Koichi Takeya; Ritsuo Aiyama; Takeshi Matsuzaki; Shusuke Hashimoto
Fluorination of triptolide and its analogues and their cytotoxicity.
Bioorganic & medicinal chemistry letters 2008;18(7):2459-63.
2008: Ji-Ean Lee; Yukio Hitotsuyanagi; Ik Hwi Kim; Tomoyo Hasuda; Koichi Takeya
A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: structure, semi-synthesis, and cytotoxicity.
Bioorganic & medicinal chemistry letters 2008;18(2):808-11.
2007: Koichi Nishimura; Yukio Hitotsuyanagi; Noriko Sugeta; Haruhiko Fukaya; Yutaka Aoyagi; Tomoyo Hasuda; Takeshi Kinoshita; Koichi Takeya
Tricalysiamides A-D, diterpenoid alkaloids from Tricalysia dubia.
Journal of natural products 2007;70(5):758-62.
2006: Yutaka Aoyagi; Yumi Nishioka; Fukuya Tobe; Tomoyo Hasuda; Koichi Takeya; Ming-Yu Gui; Yong-Ri Jin; Xu-Wen Li
Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity.
Bioorganic & medicinal chemistry 2006;14(17):5802-11.
2006: Yutaka Aoyagi; Yukio Hitotsuyanagi; Tomoyo Hasuda; Haruhiko Fukaya; Koichi Takeya; Ritsuo Aiyama; Takeshi Matsuzaki; Shusuke Hashimoto
Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.
Bioorganic & medicinal chemistry letters 2006;16(7):1947-9.
2004: Ik Hwi Kim; Satoru Takashima; Yukio Hitotsuyanagi; Tomoyo Hasuda; Koichi Takeya
New quassinoids, javanicolides C and D and javanicosides B--F, from seeds of Brucea javanica.
Journal of natural products 2004;67(5):863-8.
2004: Yukio Hitotsuyanagi; Shuichi Motegi; Tomoyo Hasuda; Koichi Takeya
Semisynthesis of an analogue of antitumor bicyclic hexapeptide RA-VII by fixing the Ala-2/Tyr-3 bond to Cis by incorporating a triazole cis-amide bond surrogate.
Organic letters 2004;6(7):1111-4.
2004: Yukio Hitotsuyanagi; Tomoyo Hasuda; Takayuki Aihara; Hiroshi Ishikawa; Kentaro Yamaguchi; Hideji Itokawa; Koichi Takeya
Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-containing analogues of RA-VII, an antitumor bicyclic hexapeptide from Rubia plants.
The Journal of organic chemistry 2004;69(5):1481-6.
2004: Ming-Yu Gui; Yutaka Aoyagi; Yong-Ri Jin; Xu-Wen Li; Tomoyo Hasuda; Koichi Takeya
Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa.
Journal of natural products 2004;67(3):373-6.