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Lisa Hasvold

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Zhi-Fu Tao; Lisa Hasvold; Joel D Leverson; Edward K Han; Ran Guan; Eric F Johnson; Vincent S Stoll; Kent D Stewart; Geoff Stamper; Niru B Soni; Jennifer J Bouska; Yan Luo; Thomas J Sowin; Nan-Horng Lin; Vincent S Giranda; Saul H Rosenberg; Thomas D Penning
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
Lisa Hasvold; Le Wang; Magdalena Przytulinska; Zhan Xiao; Zehan Chen; Wen-Zhen Gu; Philip J Merta; John Xue; Peter Kovar; Haiying Zhang; Chang Park; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.
Le Wang; Gerard M Sullivan; Laura A Hexamer; Lisa Hasvold; Reema Thalji; Magdalena Przytulinska; Zhi-Fu Tao; Gaoquan Li; Zehan Chen; Zhan Xiao; Wen-Zhen Gu; John Xue; Mai-Ha Bui; Philip J Merta; Peter Kovar; Jennifer J Bouska; Haiying Zhang; Chang Park; Kent D Stewart; Hing L Sham; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.

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All Publications

2009: Zhi-Fu Tao; Lisa Hasvold; Joel D Leverson; Edward K Han; Ran Guan; Eric F Johnson; Vincent S Stoll; Kent D Stewart; Geoff Stamper; Niru B Soni; Jennifer J Bouska; Yan Luo; Thomas J Sowin; Nan-Horng Lin; Vincent S Giranda; Saul H Rosenberg; Thomas D Penning
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
Journal of medicinal chemistry 2009;52(21):6621-36.
2008: Lisa Hasvold; Le Wang; Magdalena Przytulinska; Zhan Xiao; Zehan Chen; Wen-Zhen Gu; Philip J Merta; John Xue; Peter Kovar; Haiying Zhang; Chang Park; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(7):2311-5.
2007: Le Wang; Gerard M Sullivan; Laura A Hexamer; Lisa Hasvold; Reema Thalji; Magdalena Przytulinska; Zhi-Fu Tao; Gaoquan Li; Zehan Chen; Zhan Xiao; Wen-Zhen Gu; John Xue; Mai-Ha Bui; Philip J Merta; Peter Kovar; Jennifer J Bouska; Haiying Zhang; Chang Park; Kent D Stewart; Hing L Sham; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
Journal of medicinal chemistry 2007;50(17):4162-76.
2006: Gaoquan Li; Lisa Hasvold; Zhi-Fu Tao; Gary T Wang; Stephen L Gwaltney; Jyoti Patel; Peter Kovar; Robert B Credo; Zehan Chen; Haiying Zhang; Chang Park; Hing L Sham; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(8):2293-8.
2005: Gary T Wang; Xilu Wang; Weibo Wang; Lisa Hasvold; Gerry Sullivan; Charles W Hutchins; Steve O'Conner; Robert Gentiles; Thomas J Sowin; Jerry Cohen; Wen-Zhen Gu; Haiying Zhang; Saul H Rosenberg; Hing L Sham
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Bioorganic & medicinal chemistry letters 2005;15(1):153-8.
2004: Qun Li; Akiyo Claiborne; Tongmei Li; Lisa Hasvold; Vincent S Stoll; Steven W Muchmore; Clarissa Jakob; Wendy Gu; Jerry Cohen; Charles W Hutchins; David Frost; Saul H Rosenberg; Hing L Sham
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5367-70.
2003: Lisa Hasvold; Weibo Wang; Stephen L Gwaltney; Todd W Rockway; Lissa T J Nelson; Robert A Mantei; Stephen A Fakhoury; Gerard M Sullivan; Qun Li; Nan-Horng Lin; Le Wang; Haiying Zhang; Jerome Cohen; Wen-Zhen Gu; Kennan Marsh; Joy Bauch; Saul Rosenberg; Hing L Sham
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2003;13(22):4001-5.
2003: Yunsong Tong; Nan-Horng Lin; Le Wang; Lisa Hasvold; Weibo Wang; Nicholas Leonard; Tongmei Li; Qun Li; Jerry Cohen; Wen-Zhen Gu; Haiying Zhang; Vincent S Stoll; Joy Bauch; Kennan Marsh; Saul H Rosenberg; Hing L Sham
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorganic & medicinal chemistry letters 2003;13(9):1571-4.
2003: Stephen L Gwaltney; Stephen J O'Connor; Lissa T J Nelson; Gerard M Sullivan; Hovis Imade; Weibo Wang; Lisa Hasvold; Qun Li; Jerome Cohen; Wen-Zhen Gu; Stephen K Tahir; Joy Bauch; Kennan Marsh; Shi-Chung Ng; David Frost; Haiying Zhang; Steven W Muchmore; Clarissa Jakob; Vincent S Stoll; Charles W Hutchins; Saul H Rosenberg; Hing L Sham
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorganic & medicinal chemistry letters 2003;13(7):1363-6.
2003: Stephen L Gwaltney; Stephen J O'Connor; Lissa T J Nelson; Gerard M Sullivan; Hovis Imade; Weibo Wang; Lisa Hasvold; Qun Li; Jerome Cohen; Wen-Zhen Gu; Stephen K Tahir; Joy Bauch; Kennan Marsh; Shi-Chung Ng; David Frost; Haiying Zhang; Steven W Muchmore; Clarissa Jakob; Vincent S Stoll; Charles W Hutchins; Saul H Rosenberg; Hing L Sham
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorganic & medicinal chemistry letters 2003;13(7):1359-62.
2003: Jonathan A Meulbroek; Angela M Nilius; Qun Li; Weibo Wang; Lisa Hasvold; Beth Steiner; Daniel A Dickman; Hong Ding; David Frost; Robert C Goldman; Paul Lartey; Jacob J Plattner; Youssef L Bennani
In vivo characterization of A-192411: a novel fungicidal lipopeptide (II).
Bioorganic & medicinal chemistry letters 2003;13(3):495-7.
2003: Weibo Wang; Qun Li; Lisa Hasvold; Beth Steiner; Daniel A Dickman; Hong Ding; Akyio Clairborne; Hui-Ju Chen; David Frost; Robert C Goldman; Kennan Marsh; Yu-Hua Hui; Brian Cox; Angela M Nilius; Darlene Balli; Paul Lartey; Jacob J Plattner; Youssef L Bennani
Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I).
Bioorganic & medicinal chemistry letters 2003;13(3):489-93.
1998: Qun Li; Weibo Wang; K B Berst; Akiyo Claiborne; Lisa Hasvold; K Raye; Michael Tufano; Angela M Nilius; Linus L Shen; Robert K Flamm; JD Alder; Kennan Marsh; D Crowell; Daniel T Chu; Jacob J Plattner
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
Bioorganic & medicinal chemistry letters 1998;8(15):1953-8.