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Shigetsugu Hatakeyama

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Mio Shibata; Tadashi Ariga; Ryota Nukiwa; Tomonobu Sato; Shigetsugu Hatakeyama
TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation.
Takeshi Kondo; Masashi Watanabe; Shigetsugu Hatakeyama
TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
Tomonobu Sato; Fumihiko Okumura; Tadashi Ariga; Shigetsugu Hatakeyama
TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.

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2012: Mio Shibata; Tadashi Ariga; Ryota Nukiwa; Tomonobu Sato; Shigetsugu Hatakeyama
TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation.
Biochemical and biophysical research communications 2012;423(1):104-9.
2012: Takeshi Kondo; Masashi Watanabe; Shigetsugu Hatakeyama
TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
Biochemical and biophysical research communications 2012;422(3):501-7.
2012: Tomonobu Sato; Fumihiko Okumura; Tadashi Ariga; Shigetsugu Hatakeyama
TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.
Journal of cell science 2012;125(Pt 6):1544-55.
2012: Tomonobu Sato; Tadashi Ariga; Akihiro Iguchi; Fumihiko Okumura; Shigetsugu Hatakeyama
TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60.
Biochemical and biophysical research communications 2012;417(1):594-600.
2012: Tadasuke Tsukiyama; Miyuki Bohgaki; Mayuko Matsuda-Tsukiyama; Shinya Tanaka; Sayuri Terai; Shigetsugu Hatakeyama
Ymer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways.
Molecular medicine (Cambridge, Mass.) 2012;18():587-97.
2011: Tomonobu Sato; Tadashi Ariga; Satoshi Kano; Takeshi Kondo; Fumihiko Okumura; Shigetsugu Hatakeyama
TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.
Journal of cell science 2011;124(Pt 20):3492-502.
2011: Fumihiko Okumura; Masaki Matsumoto; Keiichi I Nakayama; Akiko J Okumura; Shigetsugu Hatakeyama
TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells.
Biochimica et biophysica acta 2011;1813(10):1784-92.
2011: Takuya Sho; Tadasuke Tsukiyama; Tomonobu Sato; Takeshi Kondo; Jun Cheng; Takashi Saku; Masahiro Asaka; Shigetsugu Hatakeyama
TRIM29 negatively regulates p53 via inhibition of Tip60.
Biochimica et biophysica acta 2011;1813(6):1245-53.
2011: Fumihiko Okumura; Koichi Yoshida; Fei Liang; Shigetsugu Hatakeyama
MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif.
Molecular and cellular biochemistry 2011;352(1-2):163-72.
2011: Miyuki Bohgaki; Masaki Matsumoto; Tatsuya Atsumi; Takeshi Kondo; Shinsuke Yasuda; Tetsuya Horita; Keiichi I Nakayama; Fumihiko Okumura; Shigetsugu Hatakeyama; Takao Koike
Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin.
Journal of cellular and molecular medicine 2011;15(1):141-51.
2009: Masaki Matsumoto; Koji Oyamada; Hidehisa Takahashi; Takamichi Sato; Shigetsugu Hatakeyama; Keiichi I Nakayama
Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways.
Proteomics 2009;9(13):3549-63.
2005: Chie Kaneko-Oshikawa; Tadashi Nakagawa; Mitsunori Yamada; Hiroo Yoshikawa; Masaki Matsumoto; Masayoshi Yada; Shigetsugu Hatakeyama; Keiko Nakayama; Keiichi I Nakayama
Mammalian E4 is required for cardiac development and maintenance of the nervous system.
Molecular and cellular biology 2005;25(24):10953-64.
2005: Masaki Matsumoto; Shigetsugu Hatakeyama; Koji Oyamada; Yoshiya Oda; Toshihide Nishimura; Keiichi I Nakayama
Large-scale analysis of the human ubiquitin-related proteome.
Proteomics 2005;5(16):4145-51.
2005: Hidehisa Takahashi; Shigetsugu Hatakeyama; Hisato Saitoh; Keiichi I Nakayama
Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
The Journal of biological chemistry 2005;280(7):5611-21.
2004: Fumihiko Okumura; Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Keiichi I Nakayama
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.
The Journal of biological chemistry 2004;279(51):53533-43.
2004: Takumi Kamura; Taichi Hara; Masaki Matsumoto; Noriko Ishida; Fumihiko Okumura; Shigetsugu Hatakeyama; Minoru Yoshida; Keiko Nakayama; Keiichi I Nakayama
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Nature cell biology 2004;6(12):1229-35.
2004: Shigetsugu Hatakeyama; Masaki Matsumoto; Takumi Kamura; Miyuki Murayama; De-Hua Chui; Emmanuel Planel; Ryosuke Takahashi; Keiichi I Nakayama; Akihiko Takashima
U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy.
Journal of neurochemistry 2004;91(2):299-307.
2004: Shigetsugu Hatakeyama; Masaki Matsumoto; Masayoshi Yada; Keiichi I Nakayama
Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(6):533-48.
2004: Masayoshi Yada; Shigetsugu Hatakeyama; Takumi Kamura; Masaaki Nishiyama; Ryosuke Tsunematsu; Hiroyuki Imaki; Noriko Ishida; Fumihiko Okumura; Keiko Nakayama; Keiichi I Nakayama
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
The EMBO journal 2004;23(10):2116-25.
2004: Keiko Nakayama; Hiroyasu Nagahama; Yoji Andrew MINAMISHIMA; Satoshi Miyake; Noriko Ishida; Shigetsugu Hatakeyama; Masatoshi Kitagawa; Shun-ichiro Iemura; Tohru Natsume; Keiichi I Nakayama
Skp2-mediated degradation of p27 regulates progression into mitosis.
Developmental cell 2004;6(5):661-72.
2004: Ryosuke Tsunematsu; Keiko Nakayama; Yuichi Oike; Masaaki Nishiyama; Noriko Ishida; Shigetsugu Hatakeyama; Yasumasa Bessho; Ryoichiro Kageyama; Toshio Suda; Keiichi I Nakayama
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
The Journal of biological chemistry 2004;279(10):9417-23.
2004: Masaki Matsumoto; Masayoshi Yada; Shigetsugu Hatakeyama; Hiroshi Ishimoto; Teiichi Tanimura; Shoji Tsuji; Akira Kakizuka; Masatoshi Kitagawa; Keiichi I Nakayama
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
The EMBO journal 2004;23(3):659-69.
2003: Takumi Kamura; Taichi Hara; Shuhei Kotoshiba; Masayoshi Yada; Noriko Ishida; Hiroyuki Imaki; Shigetsugu Hatakeyama; Keiko Nakayama; Keiichi I Nakayama
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10231-6.
2003: Keiko Nakayama; Shigetsugu Hatakeyama; Shun-ichiro Maruyama; Akira Kikuchi; Kazunori Onoé; Robert A Good; Keiichi I Nakayama
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8752-7.
2003: Shigetsugu Hatakeyama; Keiichi I Nakayama
Ubiquitylation as a quality control system for intracellular proteins.
Journal of biochemistry 2003;134(1):1-8.
2003: Kiyotaka Oshikawa; Masaki Matsumoto; Masayoshi Yada; Takumi Kamura; Shigetsugu Hatakeyama; Keiichi I Nakayama
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.
Biochemical and biophysical research communications 2003;303(4):1209-16.
2003: Shigetsugu Hatakeyama; Kei-ichi I Nakayama
U-box proteins as a new family of ubiquitin ligases.
Biochemical and biophysical research communications 2003;302(4):635-45.
2003: Chie Kaneko; Shigetsugu Hatakeyama; Masaki Matsumoto; Masayoshi Yada; Keiko Nakayama; Keiichi I Nakayama
Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.
Biochemical and biophysical research communications 2003;300(2):297-304.
2002: Ikuo Nakamichi; Shigetsugu Hatakeyama; Keiichi I Nakayama
Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18.
Molecular biology of the cell 2002;13(10):3441-51.
2002: Akimoto Miyamoto; Keiko Nakayama; Hiroyuki Imaki; Sachiko Hirose; Yi Jiang; Masaaki Abe; Tadasuke Tsukiyama; Hiroyasu Nagahama; Shigeo Ohno; Shigetsugu Hatakeyama; Keiichi I Nakayama
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta.
Nature 2002;416(6883):865-9.
2001: Taichi Hara; Takumi Kamura; Kei-Ichi Nakayama; K Oshikawa; Shigetsugu Hatakeyama; K Nakayama
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.
The Journal of biological chemistry 2001;276(52):48937-43.
2001: S Maruyama; Shigetsugu Hatakeyama; Kei-Ichi Nakayama; Noriko Ishida; K Kawakami; K Nakayama
Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.
Genomics 2001;78(3):214-22.
2001: Shigetsugu Hatakeyama; Masayoshi Yada; Masaki Matsumoto; Noriko Ishida; Kei-Ichi Nakayama
U box proteins as a new family of ubiquitin-protein ligases.
The Journal of biological chemistry 2001;276(35):33111-20.
2001: H Ageta; A Kato; Shigetsugu Hatakeyama; Kei-Ichi Nakayama; Y Isojima; Hiroyuki Sugiyama
Regulation of the level of Vesl-1S/Homer-1a proteins by ubiquitin-proteasome proteolytic systems.
The Journal of biological chemistry 2001;276(19):15893-7.
2001: K I Nakayama; Shigetsugu Hatakeyama; Kei-Ichi Nakayama
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.
Biochemical and biophysical research communications 2001;282(4):853-60.
2001: Hiroyasu Nagahama; Shigetsugu Hatakeyama; Kei-Ichi Nakayama; M Nagata; K Tomita; K Nakayama
Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development.
Anatomy and embryology 2001;203(2):77-87.
2001: Tadasuke Tsukiyama; Noriko Ishida; Michiko Shirane; Yoji Andrew MINAMISHIMA; Shigetsugu Hatakeyama; Masatoshi Kitagawa; Kei-Ichi Nakayama; K Nakayama
Down-regulation of p27Kip1 expression is required for development and function of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):304-12.
2000: Noriko Ishida; Masatoshi Kitagawa; Shigetsugu Hatakeyama; Kei-Ichi Nakayama
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
The Journal of biological chemistry 2000;275(33):25146-54.
2000: A Yamanaka; Shigetsugu Hatakeyama; K Kominami; M Kitagawa; Masaki Matsumoto; Kei-Ichi Nakayama
Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome.
Molecular biology of the cell 2000;11(8):2821-31.
2000: Kei-Ichi Nakayama; Hiroyasu Nagahama; Yoji Andrew MINAMISHIMA; Masaki Matsumoto; Ikuo Nakamichi; K Kitagawa; Michiko Shirane; Ryosuke Tsunematsu; Tadasuke Tsukiyama; Noriko Ishida; Masatoshi Kitagawa; K Nakayama; Shigetsugu Hatakeyama
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.
The EMBO journal 2000;19(9):2069-81.
1999: M Miura; Shigetsugu Hatakeyama; K Hattori; Kei-Ichi Nakayama
Structure and expression of the gene encoding mouse F-box protein, Fwd2.
Genomics 1999;62(1):50-8.
1999: K Hattori; Shigetsugu Hatakeyama; Michiko Shirane; Masaki Matsumoto; Kei-Ichi Nakayama
Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha.
The Journal of biological chemistry 1999;274(42):29641-7.
1999: Michiko Shirane; Shigetsugu Hatakeyama; K Hattori; Kei-Ichi Nakayama; K Nakayama
Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.
The Journal of biological chemistry 1999;274(40):28169-74.
1999: Michiko Shirane; Y Harumiya; Noriko Ishida; A Hirai; C Miyamoto; Shigetsugu Hatakeyama; Kei-Ichi Nakayama; Masatoshi Kitagawa
Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing.
The Journal of biological chemistry 1999;274(20):13886-93.
1999: Masatoshi Kitagawa; Shigetsugu Hatakeyama; Michiko Shirane; Masaki Matsumoto; Noriko Ishida; K Hattori; Ikuo Nakamichi; Akira Kikuchi; Kei-Ichi Nakayama; K Nakayama
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
The EMBO journal 1999;18(9):2401-10.
1999: Shigetsugu Hatakeyama; Masatoshi Kitagawa; Kei-Ichi Nakayama; Michiko Shirane; Masaki Matsumoto; K Hattori; H Higashi; H Nakano; Koji Okumura; Kazunori Onoé; Robert A Good; K Nakayama
Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3859-63.
1997: Shigetsugu Hatakeyama
[Degradation system for cellular functional molecules].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(14 Suppl):2145-53.