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Tsutomu Hatano

Research Profile

Chemicals & Drugs

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Vancomycin Resistance

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High Pressure Liquid Chromatography

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Hidekazu Ishimoto; Yoshiaki Amakura; Tsutomu Hatano; Akihiro Tai; Takashi Yoshida; Morio Yoshimura; Hideyuki Ito
Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay.
Hidekazu Ishimoto; Hideyuki Ito; Yuki Myojin; Mari Shibata; Yukio Sugimoto; Akihiro Tai; Tsutomu Hatano
In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A.
Satomi Onoue; Yoshiki Seto; Tsutomu Hatano; Ryo Inoue; Hideyuki Ito; Masanori Ochi; Shizuo Yamada
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.

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All Publications

2012: Hidekazu Ishimoto; Yoshiaki Amakura; Tsutomu Hatano; Akihiro Tai; Takashi Yoshida; Morio Yoshimura; Hideyuki Ito
Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay.
Bioscience, biotechnology, and biochemistry 2012;76(2):395-9.
2011: Hidekazu Ishimoto; Hideyuki Ito; Yuki Myojin; Mari Shibata; Yukio Sugimoto; Akihiro Tai; Tsutomu Hatano
In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A.
Bioorganic & medicinal chemistry letters 2011;21(19):5901-4.
2011: Satomi Onoue; Yoshiki Seto; Tsutomu Hatano; Ryo Inoue; Hideyuki Ito; Masanori Ochi; Shizuo Yamada
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
Phytochemistry 2011;72(14-15):1814-20.
2011: Xiaomeng Zhang; Tsutomu Hatano; Rie Ishida; Tomonori Kamiya; Goro Okamoto; Yuta Yuhara; Sakae Arimoto-Kobayashi
Anti-genotoxic activity of Vitis coignetiae Pulliat towards heterocyclic amines and isolation and identification of caftaric acid as an antimutagenic component from the juice.
Mutation research 2011;723(2):182-9.
2010: Akiko Nozaki; Eizo Takahashi; Keinosuke Okamoto; Hideyuki Ito; Tsutomu Hatano
[Antifungal activity of essential oils and their constituents against Candida spp. and their effects on activity of amphotericin B].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(6):895-902.
2010: Yuka Kimura; Hideyuki Ito; Tsutomu Hatano
Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity.
Biological & pharmaceutical bulletin 2010;33(12):1977-82.
2010: Yuka Kimura; Hideyuki Ito; Ryoko Ohnishi; Tsutomu Hatano
Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2010;48(1):429-35.
2009: Akiko Nozaki; Toshikiro Kimura; Hideyuki Ito; Tsutomu Hatano
Interaction of polyphenolic metabolites with human serum albumin: a circular dichroism study.
Chemical & pharmaceutical bulletin 2009;57(9):1019-23.
2009: Naokazu Kumura; Hirotaka Furukawa; Arnold N Onyango; Minoru Izumi; Shuhei Nakajima; Hideyuki Ito; Tsutomu Hatano; Hye-Sook Kim; Yusuke Wataya; Naomichi Baba
Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid.
Chemistry and physics of lipids 2009;160(2):114-20.
2009: Mohamed A A Orabi; Shoko Taniguchi; Tsutomu Hatano
Monomeric and dimeric hydrolysable tannins of Tamarix nilotica.
Phytochemistry 2009;70(10):1286-93.
2009: Mei-Hua Liu; Nao Otsuka; Kumiko Noyori; Sumiko Shiota; Wakano Ogawa; Teruo Kuroda; Tsutomu Hatano; Tomofusa Tsuchiya
Synergistic effect of kaempferol glycosides purified from Laurus nobilis and fluoroquinolones on methicillin-resistant Staphylococcus aureus.
Biological & pharmaceutical bulletin 2009;32(3):489-92.
2009: Akiko Nozaki; Mami Hori; Toshikiro Kimura; Hideyuki Ito; Tsutomu Hatano
Interaction of polyphenols with proteins: binding of (-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism.
Chemical & pharmaceutical bulletin 2009;57(2):224-8.
2008: Tsutomu Hatano; Mayumi Tsugawa; Miwako Kusuda; Shoko Taniguchi; Takashi Yoshida; Sumiko Shiota; Tomofusa Tsuchiya
Enhancement of antibacterial effects of epigallocatechin gallate, using ascorbic acid.
Phytochemistry 2008;69(18):3111-6.
2008: Nao Otsuka; Mei-Hua Liu; Sumiko Shiota; Wakano Ogawa; Teruo Kuroda; Tsutomu Hatano; Tomofusa Tsuchiya
Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis.
Biological & pharmaceutical bulletin 2008;31(9):1794-7.
2008: Yuka Kimura; Hideyuki Ito; Miyuki Kawaji; Takao Ikami; Tsutomu Hatano
Characterization and antioxidative properties of oligomeric proanthocyanidin from prunes, dried fruit of Prunus domestica L.
Bioscience, biotechnology, and biochemistry 2008;72(6):1615-8.
2008: Hideyuki Ito; Xiu-Lan Sun; Makiko Watanabe; Motoi Okamoto; Tsutomu Hatano
Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells.
Bioscience, biotechnology, and biochemistry 2008;72(3):885-8.
2008: Hideyuki Ito; Ayumu Iguchi; Tsutomu Hatano
Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats.
Journal of agricultural and food chemistry 2008;56(2):393-400.
2007: Xiu-Lan Sun; Hideyuki Ito; Takayoshi Masuoka; Chiaki Kamei; Tsutomu Hatano
Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task.
Biological & pharmaceutical bulletin 2007;30(9):1727-31.
2007: Kumiko Horiuchi; Sumiko Shiota; Tsutomu Hatano; Takashi Yoshida; Teruo Kuroda; Tomofusa Tsuchiya
Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).
Biological & pharmaceutical bulletin 2007;30(6):1147-9.
2007: Hideyuki Ito; Masateru Miyake; Eisei Nishitani; Kyoko Miyashita; Morio Yoshimura; Takashi Yoshida; Midori Takasaki; Takao Konoshima; Mutsuo Kozuka; Tsutomu Hatano
Cowaniin, a C-glucosidic ellagitannin dimer linked through catechin from Cowania mexicana.
Chemical & pharmaceutical bulletin 2007;55(3):492-4.
2007: Hideyuki Ito; Takahiro Okuda; Toshiyuki Fukuda; Tsutomu Hatano; Takashi Yoshida
Two novel dicarboxylic Acid derivatives and a new dimeric hydrolyzable tannin from walnuts.
Journal of agricultural and food chemistry 2007;55(3):672-9.
2007: Kumiko Horiuchi; Sumiko Shiota; Teruo Kuroda; Tsutomu Hatano; Takashi Yoshida; Tomofusa Tsuchiya
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis.
Biological & pharmaceutical bulletin 2007;30(2):287-90.
2006: Ryoko Ohnishi; Hideyuki Ito; Naoki Kasajima; Miyuki Kaneda; Reiko Kariyama; Hiromi Kumon; Tsutomu Hatano; Takashi Yoshida
Urinary excretion of anthocyanins in humans after cranberry juice ingestion.
Bioscience, biotechnology, and biochemistry 2006;70(7):1681-7.
2006: Chihiro Nagoshi; Sumiko Shiota; Teruo Kuroda; Tsutomu Hatano; Takashi Yoshida; Reiko Kariyama; Tomofusa Tsuchiya
Synergistic effect of [10]-gingerol and aminoglycosides against vancomycin-resistant enterococci (VRE).
Biological & pharmaceutical bulletin 2006;29(3):443-7.
2005: Tae Hoon Kim; Hideyuki Ito; Tsutomu Hatano; Toshio Hasegawa; Aiko Akiba; Takahisa Machiguchi; Takashi Yoshida
Bisabolane- and santalane-type sesquiterpenoids from Santalum album of Indian origin.
Journal of natural products 2005;68(12):1805-8.
2004: Tsutomu Hatano; Kazutoshi Inada; Tomo-Omi Ogawa; Hideyuki Ito; Takashi Yoshida
Aliphatic acid amides of the fruits of Zanthoxylum piperitum.
Phytochemistry 2004;65(18):2599-604.
2004: Intan Safinar Ismail; Hideyuki Ito; Tsutomu Hatano; Shoko Taniguchi; Takashi Yoshida
Two new analogues of trijugin-type limonoids from the leaves of Sandoricum koetjape.
Chemical & pharmaceutical bulletin 2004;52(9):1145-7.
2003: Intan Safinar Ismail; Hideyuki Ito; Tsutomu Hatano; Shoko Taniguchi; Takashi Yoshida
Modified limonoids from the leaves of Sandoricum koetjape.
Phytochemistry 2003;64(8):1345-9.
2003: Tsutomu Hatano; Mami Hori; Richard W Hemingway; Takashi Yoshida
Size exclusion chromatographic analysis of polyphenol-serum albumin complexes.
Phytochemistry 2003;63(7):817-23.
2002: Shoko Taniguchi; Kyoko Uechi; Reiko Kato; Hideyuki Ito; Tsutomu Hatano; Kazufumi Yazaki; Takashi Yoshida
Accumulation of hydrolyzable tannins by Aleurites fordii callus culture.
Planta medica 2002;68(12):1145-6.
2002: Hideyuki Ito; Eri Kobayashi; Shu-Hua Li; Tsutomu Hatano; Daigo Sugita; Naoki Kubo; Susumu Shimura; Yoshio Itoh; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.
Journal of agricultural and food chemistry 2002;50(8):2400-3.
2002: Tsutomu Hatano; Haruka Miyatake; Midori Natsume; Naomi Osakabe; Toshio Takizawa; Hideyuki Ito; Takashi Yoshida
Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects.
Phytochemistry 2002;59(7):749-58.
2002: Shoko Taniguchi; Yoko Imayoshi; Eri Kobayashi; Yoshie Takamatsu; Hideyuki Ito; Tsutomu Hatano; Hiroshi Sakagami; Harukuni Tokuda; Hoyoku Nishino; Daigo Sugita; Susumu Shimura; Takashi Yoshida
Production of bioactive triterpenes by Eriobotrya japonica calli.
Phytochemistry 2002;59(3):315-23.
2002: Shoko Taniguchi; Yoko Imayoshi; Ryoko Yabu-uchi; Hideyuki Ito; Tsutomu Hatano; Takashi Yoshida
A macrocyclic ellagitannin trimer, oenotherin T(1), from Oenothera species.
Phytochemistry 2002;59(2):191-5.
2001: Hideyuki Ito; Eri Kobayashi; Shu-Hua Li; Tsutomu Hatano; Daigo Sugita; N Kubo; Susumu Shimura; Yoshio Itoh; Takashi Yoshida
Megastigmane glycosides and an acylated triterpenoid from Eriobotrya japonica.
Journal of natural products 2001;64(6):737-40.
2000: T Okuda; Takashi Yoshida; Tsutomu Hatano
Correlation of oxidative transformations of hydrolyzable tannins and plant evolution.
Phytochemistry 2000;55(6):513-29.
2000: Hideyuki Ito; Eri Kobayashi; Y Takamatsu; Shu-Hua Li; Tsutomu Hatano; H Sakagami; K Kusama; K Satoh; Daigo Sugita; Susumu Shimura; Yoshio Itoh; Takashi Yoshida
Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines.
Chemical & pharmaceutical bulletin 2000;48(5):687-93.
2000: Shoko Taniguchi; Kazufumi Yazaki; R Yabuuchi; K Kawakami; Hideyuki Ito; Tsutomu Hatano; Takashi Yoshida
Galloylglucoses and riccionidin A in Rhus javanica adventitious root cultures.
Phytochemistry 2000;53(3):357-63.
2000: Takashi Yoshida; Tsutomu Hatano; Hideyuki Ito
Chemistry and function of vegetable polyphenols with high molecular weights.
BioFactors (Oxford, England) 2000;13(1-4):121-5.
1999: Hideyuki Ito; M Miyake; Eisei Nishitani; K Mori; Tsutomu Hatano; T Okuda; Takao Konoshima; Midori Takasaki; Mutsuo Kozuka; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.
Cancer letters 1999;143(1):5-13.
1999: Tsutomu Hatano; Takashi Yoshida; R W Hemingway
Interaction of flavanoids with peptides and proteins and conformations of dimeric flavanoids in solution.
Basic life sciences 1999;66():509-26.
1999: Takashi Yoshida; Tsutomu Hatano; Hideyuki Ito; T Okuda
Highly oxidized ellagitannins and their biological activity.
Basic life sciences 1999;66():127-44.
1996: Takashi Yoshida; Hideyuki Ito; Tsutomu Hatano; M Kurata; T Nakanishi; A Inada; H Murata; Y Inatomi; N Matsuura; K Ono; H Nakane; M Noda; F A Lang; J Murata
New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.
Chemical & pharmaceutical bulletin 1996;44(8):1436-9.
1995: Tsutomu Hatano; L Han; S Taniguchi; T Okuda; Y Kiso; T Tanaka; Takashi Yoshida
Camelliatannin D, a new inhibitor of bone resorption, from Camellia japonica.
Chemical & pharmaceutical bulletin 1995;43(11):2033-5.
1995: T Okuda; Takashi Yoshida; Tsutomu Hatano
Hydrolyzable tannins and related polyphenols.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1995;66():1-117.
1994: Takashi Yoshida; T Nakazawa; Tsutomu Hatano; R C Yang; Ling-Ling Yang; K Y Yen; T Okuda
A dimeric hydrolysable tannin from Camellia oleifera.
Phytochemistry 1994;37(1):241-4.
1994: L Han; Tsutomu Hatano; Takashi Yoshida; T Okuda
Tannins of theaceous plants. V. Camelliatannins F, G and H, three new tannins from Camellia japonica L.
Chemical & pharmaceutical bulletin 1994;42(7):1399-409.
1993: H Satomi; K Umemura; A Ueno; Tsutomu Hatano; T Okuda; Tadataka Noro
Carbonic anhydrase inhibitors from the pericarps of Punica granatum L.
Biological & pharmaceutical bulletin 1993;16(8):787-90.
1992: T Okuda; Takashi Yoshida; Tsutomu Hatano
Pharmacologically active tannins isolated from medicinal plants.
Basic life sciences 1992;59():539-69.
1991: Tsutomu Hatano; T Fukuda; Y Z Liu; Tadataka Noro; T Okuda
[Phenolic constituents of licorice. IV. Correlation of phenolic constituents and licorice specimens from various sources, and inhibitory effects of licorice extracts on xanthine oxidase and monoamine oxidase].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1991;111(6):311-21.
1991: Tsutomu Hatano; T Fukuda; Toshio Miyase; Tadataka Noro; T Okuda
Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase.
Chemical & pharmaceutical bulletin 1991;39(5):1238-43.
1991: Takashi Yoshida; T Chou; M Matsuda; T Yasuhara; K Yazaki; Tsutomu Hatano; A Nitta; T Okuda
Woodfordin D and oenothein A, trimeric hydrolyzable tannins of macro-ring structure with antitumor activity.
Chemical & pharmaceutical bulletin 1991;39(5):1157-62.
1991: Tsutomu Hatano; T Yasuhara; R Yoshihara; Y Ikegami; M Matsuda; K Yazaki; I Agata; S Nishibe; Tadataka Noro; M Yoshizaki
Inhibitory effects of galloylated flavonoids on xanthine oxidase.
Planta medica 1991;57(1):83-4.
1990: Tsutomu Hatano; T Yasuhara; R Yoshihara; I Agata; Tadataka Noro; T Okuda
Effects of interaction of tannins with co-existing substances. VII. Inhibitory effects of tannins and related polyphenols on xanthine oxidase.
Chemical & pharmaceutical bulletin 1990;38(5):1224-9.
1986: T Okuda; Tsutomu Hatano; I Agata; S Nishibe; K Kimura
[Tannins in Artemisia montana. A. princeps and related species of plant].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1986;106(10):894-9.