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Makoto Asamoto

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Aya Naiki-Ito; Makoto Asamoto; Hiroyuki Kato; Taku Naiki; Tomoyuki Shirai
Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication.
Kumiko Ogawa; Pornsiri Pitchakarn; Shinya Sato; Shugo Suzuki; Satoru Takahashi; Seishiro Takahashi; Mingxi Tang; Makoto Asamoto; Teera Chewonarin; Aya Naiki-Ito; Tomoyuki Shirai
Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells.
Taku Naiki; Aya Naiki-Ito; Makoto Asamoto; Kenjiro Kohri; Satoru Takahashi; Naomi Toyoda-Hokaiwado; Keiichi Tozawa; Tomoyuki Shirai
Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice.

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2012: Aya Naiki-Ito; Makoto Asamoto; Hiroyuki Kato; Taku Naiki; Tomoyuki Shirai
Age-dependent carcinogenic susceptibility in rat liver is related to potential of gap junctional intercellular communication.
Toxicologic pathology 2012;40(5):715-21.
2012: Kumiko Ogawa; Pornsiri Pitchakarn; Shinya Sato; Shugo Suzuki; Satoru Takahashi; Seishiro Takahashi; Mingxi Tang; Makoto Asamoto; Teera Chewonarin; Aya Naiki-Ito; Tomoyuki Shirai
Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells.
Cancer science 2012;103(5):860-7.
2012: Taku Naiki; Aya Naiki-Ito; Makoto Asamoto; Kenjiro Kohri; Satoru Takahashi; Naomi Toyoda-Hokaiwado; Keiichi Tozawa; Tomoyuki Shirai
Organ specific Gst-pi expression of the metastatic androgen independent prostate cancer cells in nude mice.
The Prostate 2012;72(5):533-41.
2012: Pornsiri Pitchakarn; Wilart Pompimon; Makoto Asamoto; Pornngarm Limtrakul; Kumiko Ogawa; Shugo Suzuki; Satoru Takahashi; Tomoyuki Shirai
Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(3-4):840-7.
2011: Shugo Suzuki; Satoru Takahashi; Kentaro Takeshita; Makoto Asamoto; Pornsiri Pitchakarn; Shinya Sato; Tomoyuki Shirai
Roles for rat hepatocyte malignant transforming factor (HMTF) in late stage of hepatocarcinogenesis.
Toxicologic pathology 2011;39(7):1084-90.
2011: Pornsiri Pitchakarn; Shugo Suzuki; Kumiko Ogawa; Wilart Pompimon; Satoru Takahashi; Makoto Asamoto; Pornngarm Limtrakul; Tomoyuki Shirai
Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf.
Cancer letters 2011;306(2):142-50.
2011: Kentaro Takeshita; Satoru Takahashi; Mingxi Tang; Azman Seeni; Makoto Asamoto; Tomoyuki Shirai
Hypertension is positively associated with prostate cancer development in the TRAP transgenic rat model.
Pathology international 2011;61(4):202-9.
2011: Ming Xi Tang; Kumiko Ogawa; Makoto Asamoto; Teera Chewonarin; Shugo Suzuki; Takuji Tanaka; Tomoyuki Shirai
Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.
Nutrition and cancer 2011;63(2):227-33.
2010: Pornsiri Pitchakarn; Kumiko Ogawa; Shugo Suzuki; Satoru Takahashi; Makoto Asamoto; Teera Chewonarin; Pornngarm Limtrakul; Tomoyuki Shirai
Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo.
Cancer science 2010;101(10):2234-40.
2010: Shugo Suzuki; Kentaro Takeshita; Yuko Doi; Makoto Asamoto; Satoru Takahashi; Aya Naiki-Ito; Tomoyuki Shirai
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression.
Toxicologic pathology 2010;38(4):583-91.
2010: Shinya Sato; Satoru Takahashi; Makoto Asamoto; Taku Naiki; Aya Naiki-Ito; Kiyofumi Asai; Tomoyuki Shirai
Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro.
The Prostate 2010;70(3):229-38.
2010: Aya Naiki-Ito; Makoto Asamoto; Taku Naiki; Kumiko Ogawa; Satoru Takahashi; Shinya Sato; Tomoyuki Shirai
Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat.
Toxicologic pathology 2010;38(2):280-6.
2009: MingXi Tang; Makoto Asamoto; Kumiko Ogawa; Aya Naiki-Ito; Shinya Sato; Satoru Takahashi; Tomoyuki Shirai
Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor.
Pathology international 2009;59(11):790-6.
2009: Shugo Suzuki; Kentaro Takeshita; Makoto Asamoto; Satoru Takahashi; Hitoshi Kandori; Kazunari Tsujimura; Fumiyo Saito; Kazuo Masuko; Tomoyuki Shirai
High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans.
Toxicology 2009;255(3):160-70.
2008: Naomi Hokaiwado; Fumitaka Takeshita; Aya Naiki-Ito; Makoto Asamoto; Takahiro Ochiya; Tomoyuki Shirai
Glutathione S-transferase Pi mediates proliferation of androgen-independent prostate cancer cells.
Carcinogenesis 2008;29(6):1134-8.
2008: Atsuya Hikosaka; Kumiko Ogawa; Satoshi Sugiura; Makoto Asamoto; Fumitaka Takeshita; Shin-Ya Sato; Makoto Nakanishi; Kenjiro Kohri; Tomoyuki Shirai
Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation.
International journal of cancer. Journal international du cancer 2008;122(6):1222-8.
2008: Shinya Sato; Mitsuru Futakuchi; Kumiko Ogawa; Makoto Asamoto; Kimihisa Nakao; Kiyofumi Asai; Tomoyuki Shirai
Transforming growth factor beta derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment.
Cancer science 2008;99(2):316-23.
2007: Aya Naiki-Ito; Makoto Asamoto; Naomi Hokaiwado; Satoru Takahashi; Hiroko Yamashita; Hiroyuki Tsuda; Kumiko Ogawa; Tomoyuki Shirai
Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens.
Cancer research 2007;67(23):11353-8.
2007: Naomi Hokaiwado; Makoto Asamoto; Mitsuru Futakuchi; Kumiko Ogawa; Satoru Takahashi; Tomoyuki Shirai
Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.
The Journal of membrane biology 2007;218(1-3):101-6.
2007: MingXi Tang; Kumiko Ogawa; Makoto Asamoto; Naomi Hokaiwado; Azman Seeni; Shugo Suzuki; Satoru Takahashi; Takuji Tanaka; Kazuhito Ichikawa; Tomoyuki Shirai
Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.
Cancer science 2007;98(4):471-7.
2006: Kazunari Tsujimura; Makoto Asamoto; Shugo Suzuki; Naomi Hokaiwado; Kumiko Ogawa; Tomoyuki Shirai
Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells.
Cancer science 2006;97(10):1002-10.
2006: Mahmoud M Said; Naomi Hokaiwado; Mingxi Tang; Kumiko Ogawa; Shugo Suzuki; Hala M Ghanem; Amr Y Esmat; Makoto Asamoto; Fawzia M Refaie; Tomoyuki Shirai
Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist.
Cancer science 2006;97(6):459-67.
2006: Masanori Kuribayashi; Makoto Asamoto; Shugo Suzuki; Naomi Hokaiwado; Kumiko Ogawa; Tomoyuki Shirai
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.
Cancer letters 2006;232(2):289-99.
2006: Seishiro Takahashi; Shugo Suzuki; Satoru Takahashi; Shingo Inaguma; Makoto Asamoto; Tomoyuki Shirai
Differences between latent and clinical prostate carcinomas: lower cell proliferation activity in latent cases.
The Prostate 2006;66(2):211-7.
2005: Masanori Kuribayashi; Jianqing Wang; Osamu Fujiwara; Yuko Doi; Kyoko Nabae; Seiko Tamano; Tadashi Ogiso; Makoto Asamoto; Tomoyuki Shirai
Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats.
Bioelectromagnetics 2005;26(7):578-88.
2005: Yoshihisa Ikeda; Young-Man Cho; Satoru Takahashi; Mingxi Tang; Makoto Asamoto; Kumiko Ogawa; Tomoyuki Shirai
Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats.
Cancer letters 2005;224(1):23-30.
2005: Hitoshi Kandori; Shugo Suzuki; Makoto Asamoto; Toshiya Murasaki; Tang Mingxi; Kumiko Ogawa; Tomoyuki Shirai
Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats.
Cancer science 2005;96(4):221-6.
2005: Kumiko Ogawa; Makoto Asamoto; Shugo Suzuki; Kazunari Tsujimura; Tomoyuki Shirai
Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions.
Medical molecular morphology 2005;38(1):23-9.
2005: Aya Ito; Makoto Asamoto; Naomi Hokaiwado; Satoru Takahashi; Tomoyuki Shirai
Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells.
Cancer letters 2005;219(1):105-12.
2005: Toshio Ichihara; Kayoko Miyashita; Mayumi Kawabe; Katsumi Imaida; Makoto Asamoto; Tadashi Ogiso; Seiko Tamano; Masao Hirose; Tomoyuki Shirai
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
The Journal of toxicological sciences 2005;30(1):1-6.
2005: Naomi Hokaiwado; Makoto Asamoto; Kumiko Ogawa; Tomoyuki Shirai
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Toxicologic pathology 2005;33(6):695-701.
2005: Tomoyuki Shirai; Mayumi Kawabe; Toshio Ichihara; Osamu Fujiwara; Masao Taki; So-ichi Watanabe; Kanako Wake; Yukio Yamanaka; Katsumi Imaida; Makoto Asamoto; Seiko Tamano
Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N-ethylnitrosourea induced central nervous system tumors in F344 rats.
Bioelectromagnetics 2005;26(1):59-68.
2004: Hiroyuki Ohnishi; Makoto Asamoto; Kazunari Tujimura; Naomi Hokaiwado; Satoru Takahashi; Kumiko Ogawa; Masanori Kuribayashi; Tadashi Ogiso; Harumi Okuyama; Tomoyuki Shirai
Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo.
Cancer science 2004;95(12):936-42.
2004: Shigeyuki Suzuki; Koichi Sato; Eiichi Katada; Yasushi Kuno; Naoto Mizoguchi; Hiroshi Tokuda; Shingo Inaguma; Makoto Asamoto; Yasuaki Dohi
Periampullary somatostatinoma and multiple gastrointestinal stromal tumors associated with von Recklinghausen's disease.
Journal of gastroenterology 2004;39(10):1011-2.
2004: Makoto Asamoto; Naomi Hokaiwado; Toshiya Murasaki; Tomoyuki Shirai
Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals.
Hepatology (Baltimore, Md.) 2004;40(1):205-10.
2004: Akihiro Naito; Akane Suzuki; Shinobu Ueda; Hiroshi Nomoto; Hiroyasu Toriyama-Baba; Makoto Asamoto; Hiroyuki Tsuda
Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats.
Cancer science 2004;95(5):399-403.
2004: Shugo Suzuki; Makoto Asamoto; Kazunari Tsujimura; Tomoyuki Shirai
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Carcinogenesis 2004;25(3):439-43.
2004: Atsuya Hikosaka; Makoto Asamoto; Naomi Hokaiwado; Koji Kato; Kazuya Kuzutani; Kenjiro Kohri; Tomoyuki Shirai
Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 2004;25(3):381-7.
2004: Naomi Hokaiwado; Makoto Asamoto; Kazunari Tsujimura; Takeshi Hirota; Toshio Ichihara; Takatomo Satoh; Tomoyuki Shirai
Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system.
Cancer science 2004;95(2):123-30.
2003: Naomi Hokaiwado; Makoto Asamoto; Young-Man Cho; Hiroyuki Tsuda; Tomoyuki Shirai
Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats.
Cancer science 2003;94(12):1042-5.
2003: Fumitaka Takeshita; Kumiko Ogawa; Makoto Asamoto; Tomoyuki Shirai
Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Cancer letters 2003;194(1):25-35.
2003: Aya Ito; Makoto Asamoto; Naomi Hokaiwado; Tomoyuki Shirai
Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre--loxP system.
Cancer letters 2003;193(2):183-8.
2003: Satoshi Sugiura; Kumiko Ogawa; Masao Hirose; Fumitaka Takeshita; Makoto Asamoto; Tomoyuki Shirai
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
Carcinogenesis 2003;24(3):547-53.
2003: Young-Man Cho; Satoru Takahashi; Makoto Asamoto; Shugo Suzuki; Shingo Inaguma; Naomi Hokaiwado; Tomoyuki Shirai
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
Cancer science 2003;94(2):153-7.
2002: Tomoyuki Shirai; Makoto Asamoto; Satoru Takahashi; Katsumi Imaida
Diet and prostate cancer.
Toxicology 2002;181-182():89-94.
2002: Shugo Suzuki; Satoru Takahashi; Makoto Asamoto; Shingo Inaguma; Tadashi Ogiso; Masao Hirose; Tomoyuki Shirai
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
Cancer letters 2002;185(1):39-45.
2002: Tomoyuki Shirai; Koji Kato; Mitsuru Futakuchi; Satoru Takahashi; Shugo Suzuki; Katsumi Imaida; Makoto Asamoto
Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas.
Mutation research 2002;506-507():129-36.
2002: Makoto Asamoto; Hiroyasu Toriyama-Baba; Takamasa Ohnishi; Akihiro Naito; Tomonori Ota; Akira Ando; Takahiro Ochiya; Hiroyuki Tsuda
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.
Japanese journal of cancer research : Gann 2002;93(7):744-51.
2002: Makoto Asamoto; Naomi Hokaiwado; Young-Man Cho; Tomoyuki Shirai
Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control.
Carcinogenesis 2002;23(3):463-7.
2002: Mitsuru Futakuchi; Masao Hirose; Katsumi Imaida; Satoru Takahashi; Kumiko Ogawa; Makoto Asamoto; Tokutaro Miki; Tomoyuki Shirai
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Carcinogenesis 2002;23(2):283-7.
2002: Makoto Asamoto; Tomonori Ota; Hiroyasu Toriyama-Baba; Naomi Hokaiwado; Akihiro Naito; Hiroyuki Tsuda
Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment.
Japanese journal of cancer research : Gann 2002;93(1):32-5.
2001: Hiroyasu Toriyama-Baba; Masaaki Iigo; Makoto Asamoto; Y Iwahori; Cheol-Beom Park; Beom Seok Han; Nobuo Takasuka; T Kakizoe; C Ishikawa; K Yazawa; E Araki; Hiroyuki Tsuda
Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 2001;92(11):1175-83.
2001: T Mori; Katsumi Imaida; Seiko Tamano; Masashi Sano; Satoru Takahashi; Makoto Asamoto; M Takeshita; H Ueda; Tomoyuki Shirai
Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl.
Japanese journal of cancer research : Gann 2001;92(10):1026-33.
2001: Katsumi Imaida; Masashi Sano; Seiko Tamano; Makoto Asamoto; Kumiko Ogawa; Mitsuru Futakuchi; Tomoyuki Shirai
Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate.
Carcinogenesis 2001;22(8):1295-9.
2001: Makoto Asamoto; Naomi Hokaiwado; Young-Man Cho; Satoru Takahashi; Y Ikeda; Katsumi Imaida; Tomoyuki Shirai
Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent.
Cancer research 2001;61(12):4693-700.
2001: Hiroyuki Tsuda; Makoto Asamoto; Takahiro Ochiya; Hiroyasu Toriyama-Baba; Akihiro Naito; Tomonori Ota; T Sekiya; Masaaki Terada
High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis.
Mutation research 2001;477(1-2):173-82.
2001: Makoto Asamoto; Naomi Hokaiwado; Young-Man Cho; Y Ikeda; Satoru Takahashi; Tomoyuki Shirai
Metastasizing neuroblastomas from taste buds in rats transgenic for the Simian virus 40 large T antigen under control of the probasin gene promoter.
Toxicologic pathology 2001;29(3):363-8.
2001: Kumiko Ogawa; H Nakanishi; F Takeshita; Mitsuru Futakuchi; Makoto Asamoto; Katsumi Imaida; Masae Tatematsu; Tomoyuki Shirai
Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice.
International journal of cancer. Journal international du cancer 2001;91(6):797-802.
2001: Katsumi Imaida; Seiko Tamano; Koji Kato; Y Ikeda; Makoto Asamoto; Satoru Takahashi; Z Nir; Michiaki Murakoshi; Hoyoku Nishino; Tomoyuki Shirai
Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.
Carcinogenesis 2001;22(3):467-72.
2001: Naomi Hokaiwado; Makoto Asamoto; Young-Man Cho; Katsumi Imaida; Tomoyuki Shirai
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Cancer letters 2001;163(2):187-90.
2001: R Tokuzen; Y Iwahori; Makoto Asamoto; Masaaki Iigo; F Hasegawa; T Satoh; M Ishidate; Hiroyuki Tsuda
Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors.
Pathology international 2001;51(2):65-71.
2000: Katsumi Imaida; A Hagiwara; H Yoshino; Seiko Tamano; Masashi Sano; Mitsuru Futakuchi; Kumiko Ogawa; Makoto Asamoto; Tomoyuki Shirai
Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.
Cancer letters 2000;155(1):105-14.
2000: Tomonori Ota; Makoto Asamoto; Hiroyasu Toriyama-Baba; F Yamamoto; Yoichiro Matsuoka; Takahiro Ochiya; T Sekiya; Masaaki Terada; H Akaza; Hiroyuki Tsuda
Transgenic rats carrying copies of the human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine bladder carcinogenesis.
Carcinogenesis 2000;21(7):1391-6.
2000: Nobuyuki Ito; Katsumi Imaida; Makoto Asamoto; Tomoyuki Shirai
Early detection of carcinogenic substances and modifiers in rats.
Mutation research 2000;462(2-3):209-17.
2000: M Yaono; Seiko Tamano; T Mori; Koji Kato; Katsumi Imaida; Makoto Asamoto; Tomoyuki Shirai
Lobe specific effects of testosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.
Cancer letters 2000;150(1):33-40.
2000: Makoto Asamoto; Takahiro Ochiya; Hiroyasu Toriyama-Baba; Tomonori Ota; T Sekiya; Masaaki Terada; Hiroyuki Tsuda
Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis.
Carcinogenesis 2000;21(2):243-9.
2000: Kumiko Ogawa; Naoya Kimoto; Makoto Asamoto; M Nakanishi; Satoru Takahashi; Tomoyuki Shirai
Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium.
Carcinogenesis 2000;21(1):117-21.
1999: Tomoyuki Shirai; L Cui; Satoru Takahashi; Mitsuru Futakuchi; Makoto Asamoto; Koji Kato; Nobuyuki Ito
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate.
Cancer letters 1999;143(2):217-21.
1998: Makoto Asamoto; T Hori; H Baba-Toriyama; M Sano; S Takahashi; Hiroyuki Tsuda; T Shirai
p16 gene overexpression in mouse bladder carcinomas.
Cancer letters 1998;127(1-2):9-13.
1998: Makoto Asamoto; T Toriyama-Baba; Vladimir A Krutovskikh; S M Cohen; Hiroyuki Tsuda
Enhanced tumorigenicity of rat bladder squamous cell carcinoma cells after abrogation of gap junctional intercellular communication.
Japanese journal of cancer research : Gann 1998;89(5):481-6.
1998: Hiroyuki Tsuda; Kazunori Sekine; J Nakamura; Y Ushida; T Kuhara; Nobuo Takasuka; Dae Joong Kim; Makoto Asamoto; H Baba-Toriyama; Malcolm Moore; Hoyoku Nishino; T Kakizoe
Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats.
Advances in experimental medicine and biology 1998;443():273-84.
1997: Vladimir A Krutovskikh; Makoto Asamoto; Nobuo Takasuka; Michiaki Murakoshi; Hoyoku Nishino; Hiroyuki Tsuda
Differential dose-dependent effects of alpha-, beta-carotenes and lycopene on gap-junctional intercellular communication in rat liver in vivo.
Japanese journal of cancer research : Gann 1997;88(12):1121-4.
1997: Dae Joong Kim; Nobuo Takasuka; J M Kim; Kazunori Sekine; T Ota; Makoto Asamoto; Michiaki Murakoshi; Hoyoku Nishino; Z Nir; Hiroyuki Tsuda
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Cancer letters 1997;120(1):15-22.
1997: I Suzuki; Masaaki Iigo; C Ishikawa; T Kuhara; Makoto Asamoto; T Kunimoto; Malcolm Moore; K Yazawa; E Araki; Hiroyuki Tsuda
Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon-carcinoma-26 cells are associated with reduced matrix metalloproteinase-2 and -9 activities.
International journal of cancer. Journal international du cancer 1997;73(4):607-12.
1997: Kazunori Sekine; E Watanabe; J Nakamura; Nobuo Takasuka; Dae Joong Kim; Makoto Asamoto; Vladimir A Krutovskikh; H Baba-Toriyama; T Ota; Malcolm Moore; M Masuda; H Sugimoto; Hoyoku Nishino; T Kakizoe; Hiroyuki Tsuda
Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats.
Japanese journal of cancer research : Gann 1997;88(6):523-6.
1997: Katsumi Imaida; R Hasegawa; T Kato; Mitsuru Futakuchi; S Takahashi; K Ogawa; Makoto Asamoto; T Yamamoto; K Suzuki; T Inagaki; N Shinagawa; Tomoyuki Shirai
Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital.
Pathology international 1997;47(5):293-300.
1997: K Matsumoto; T Iwase; I Hirono; Y Nishida; Y Iwahori; T Hori; Makoto Asamoto; Nobuo Takasuka; D J Kim; T Ushijima; M Nagao; Hiroyuki Tsuda
Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat.
Japanese journal of cancer research : Gann 1997;88(2):129-36.
1997: Makoto Asamoto; Y Iwahori; T Okamura; T Shirai; Hiroyuki Tsuda
Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas.
Japanese journal of clinical oncology 1997;27(1):22-5.
1997: T Hori; Makoto Asamoto; Vladimir A Krutovskikh; Y Iwahori; M Maeda; Hiroyasu Toriyama-Baba; Nobuo Takasuka; Hiroyuki Tsuda
Triazine derivatives inhibit rat hepatocarcinogenesis but do not enhance gap junctional intercellular communication.
Japanese journal of cancer research : Gann 1997;88(1):12-7.
1997: Masaaki Iigo; T Nakagawa; C Ishikawa; Y Iwahori; Makoto Asamoto; K Yazawa; E Araki; Hiroyuki Tsuda
Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung.
British journal of cancer 1997;75(5):650-5.
1996: Hiroyuki Tsuda; Makoto Asamoto; Y Iwahori; T Hori; T Ota; H Baba-Toriyama; N Uehara; Dae Joong Kim; Vladimir A Krutovskikh; Nobuo Takasuka; Takayuki Tsuchiya; M Mutai; M Tatematsu; H Yamasaki
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Carcinogenesis 1996;17(11):2441-8.
1996: N Uehara; Y Iwahori; Makoto Asamoto; H Baba-Toriyama; Masaaki Iigo; M Ochiai; M Nagao; M Nakayama; M Degawa; K Matsumoto; I Hirono; H Beppu; K Fujita; Hiroyuki Tsuda
Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with beta-carotene, alpha-tocopherol and freeze-dried aloe.
Japanese journal of cancer research : Gann 1996;87(4):342-8.
1996: S Wada; T Kato; M Mutai; K Ozaki; S Yamaguchi; Dae Joong Kim; H Baba-Toriyama; Makoto Asamoto; Nobuyuki Ito; Hiroyuki Tsuda
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Japanese journal of cancer research : Gann 1996;87(3):240-6.
1996: Hiroyuki Tsuda; Y Iwahori; Makoto Asamoto; H Baba-Toriyama; T Hori; Dae Joong Kim; N Uehara; Masaaki Iigo; Nobuo Takasuka; Michiaki Murakoshi; H Nishino; T Kakizoe; E Araki; K Yazawa
Demonstration of organotropic effects of chemopreventive agents in multiorgan carcinogenesis models.
IARC scientific publications 1996;(139):143-50.
1995: Hiroyuki Tsuda; Makoto Asamoto; H Baba-Toriyama; Y Iwahori; T Hori; Dae Joong Kim; Takayuki Tsuchiya; M Mutai; H Yamasaki
Clofibrate-induced neoplastic development in the rat liver is associated with decreased connexin 32 expression but not with a co-ordinated shift in expression of marker enzymes.
Toxicology letters 1995;82-83():693-9.
1995: Nobuyuki Ito; R Hasegawa; Katsumi Imaida; Masao Hirose; Makoto Asamoto; Tomoyuki Shirai
Concepts in multistage carcinogenesis.
Critical reviews in oncology/hematology 1995;21(1-3):105-133.
1995: Kumiko Ogawa; Y Shichino; M Tatematsu; C Furihata; Makoto Asamoto; S Nagase; Tomoyuki Shirai; Nobuyuki Ito
Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats.
Cancer letters 1995;96(2):219-24.
1995: Hiroyuki Tsuda; Makoto Asamoto; H Baba; Y Iwahori; K Matsumoto; T Iwase; Y Nishida; S Nagao; K Hakoi; S Yamaguchi
Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.
Carcinogenesis 1995;16(1):101-5.
1994: Hiroyuki Tsuda; N Uehara; Y Iwahori; Makoto Asamoto; Masaaki Iigo; M Nagao; K Matsumoto; M Ito; I Hirono
Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat.
Japanese journal of cancer research : Gann 1994;85(12):1214-9.
1994: S Takahashi; Makoto Asamoto; T Nakazawa; T Kosaki; K Katsumi; T Shirai
Robb-Smith type malignant histiocytosis associated with a mediastinal germ cell tumor.
Japanese journal of clinical oncology 1994;24(6):327-30.
1994: Makoto Asamoto; Satoru Takahashi; Katsumi Imaida; Tomoyuki Shirai; S Fukushima
Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis.
Carcinogenesis 1994;15(10):2163-6.
1994: Marc Mesnil; Makoto Asamoto; Colette Piccoli; Horashi Yamasaki
Possible molecular mechanism of loss of homologous and heterologous gap junctional intercellular communication in rat liver epithelial cell lines.
Cell adhesion and communication 1994;2(5):377-84.
1993: K Ozaki; T Kato; Makoto Asamoto; C P Wild; R Montesano; S Nagao; T Iwase; K Matsumoto; Hiroyuki Tsuda
Decreased dimethylnitrosamine-induced O6- and N7-methyldeoxyguanosine levels correlate with development and progression of lesions in rat hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1993;84(12):1245-51.
1993: J L de Camargo; Hiroyuki Tsuda; Makoto Asamoto; Y Tagawa; S Wada; S Nagase; Nobuyuki Ito
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Toxicologic pathology 1993;21(4):409-16.
1992: Makoto Asamoto; Katsumi Imaida; R Hasegawa; K Hotta; S Fukushima
Change of membrane potential in rat urinary bladder epithelium treated with sodium L-ascorbate.
Cancer letters 1992;63(1):1-5.
1991: J L de Camargo; Tomoyuki Shirai; T Kato; Makoto Asamoto; S Fukushima
Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Japanese journal of cancer research : Gann 1991;82(11):1220-5.
1991: W M Jongen; D J Fitzgerald; Makoto Asamoto; Colette Piccoli; Thomas Slaga; Daniel Gros; M Takeichi; Horashi Yamasaki
Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.
The Journal of cell biology 1991;114(3):545-55.
1991: M Okumura; Tomoyuki Shirai; Makoto Asamoto; Tadashi Ogiso; S Fukushima
Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)-nitrosamine administration.
Cancer letters 1991;58(1-2):81-5.
1991: S Fukushima; Y Kurata; R Hasegawa; Makoto Asamoto; M A Shibata; Seiko Tamano
L-ascorbic acid amplification of bladder carcinogenesis promotion by K2CO3.
Cancer research 1991;51(10):2548-51.
1991: Makoto Asamoto; Masahito Oyamada; A el Aoumari; Daniel Gros; Horashi Yamasaki
Molecular mechanisms of TPA-mediated inhibition of gap-junctional intercellular communication: evidence for action on the assembly or function but not the expression of connexin 43 in rat liver epithelial cells.
Molecular carcinogenesis 1991;4(4):322-7.
1990: Makoto Asamoto; Y Shichino; Hiroyuki Tsuda; Nobuyuki Ito
Inhibition of rat hepatic glutathione S-transferase placental form positive foci development by concomitant administration of antioxidants to carcinogen-treated rats.
Cancer letters 1990;55(1):25-9.
1990: Makoto Asamoto; R Hasegawa; T Masuko; Y Hashimoto; K Ueda; K Ohtaguro; S Sasaki; H Washida; S Fukushima
Immunohistochemical analysis of c-erbB-2 oncogene product and epidermal growth factor receptor expression in human urinary bladder carcinomas.
Acta pathologica japonica 1990;40(5):322-6.
1990: R Hasegawa; Satoru Takahashi; Makoto Asamoto; Tomoyuki Shirai; S Fukushima
Species differences in sodium o-phenylphenate induction of urinary bladder lesions.
Cancer letters 1990;50(2):87-91.
1989: Makoto Asamoto; Hiroyuki Tsuda; T Kato; Nobuyuki Ito; T Masuko; Y Hashimoto; S Nagase
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Japanese journal of cancer research : Gann 1989;80(11):1041-6.
1989: Makoto Asamoto; Hiroyuki Tsuda; M Kagawa; J L de Camargo; Nobuyuki Ito; S Nagase
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term assay system: quantitation of glutathione S-transferase P-positive foci development.
Japanese journal of cancer research : Gann 1989;80(10):939-44.
1989: W Thamavit; S Fukushima; Y Kurata; Makoto Asamoto; Nobuyuki Ito
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Cancer letters 1989;45(2):93-101.
1989: S Fukushima; Makoto Asamoto; K Imaida; M N el-Bolkainy; H N Tawfik; Nobuyuki Ito
Comparative study of urinary bladder carcinomas in Japanese and Egyptians.
Acta pathologica japonica 1989;39(3):176-9.
1989: Hiroyuki Tsuda; T Inoue; Makoto Asamoto; S Fukushima; Nobuyuki Ito; T Okamura; K Ohtaguro; H Washida; K Satoh; Z Amelizad
Comparison of enzyme phenotypes in human bladder tumours and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder. A combined histochemical and immunohistochemical approach.
Virchows Archiv. B, Cell pathology including molecular pathology 1989;56(5):307-16.
1988: Hiroyuki Tsuda; Makoto Asamoto; M Kagawa; S Uwagawa; K Inoue; M Inui; Nobuyuki Ito
Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver.
Carcinogenesis 1988;9(6):1103-5.
1988: Hiroyuki Tsuda; Makoto Asamoto; Tadashi Ogiso; T Inoue; Nobuyuki Ito; M Nagao
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.
Japanese journal of cancer research : Gann 1988;79(6):691-7.
1988: Nobuyuki Ito; Katsumi Imaida; J L de Camargo; Satoru Takahashi; Makoto Asamoto; Hiroyuki Tsuda
A new medium-term bioassay system for detection of environmental carcinogens using diethylnitrosamine-initiated rat liver followed by D-galactosamine treatment and partial hepatectomy.
Japanese journal of cancer research : Gann 1988;79(5):573-5.
1988: Hiroyuki Tsuda; M A Moore; Makoto Asamoto; T Inoue; Nobuyuki Ito; K Satoh; A Ichihara; T Nakamura; Z Amelizad; F Oesch
Effect of modifying agents on the phenotypic expression of cytochrome P-450, glutathione S-transferase molecular forms, microsomal epoxide hydrolase, glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase in rat liver preneoplastic lesions.
Carcinogenesis 1988;9(4):547-54.
1988: T Masui; Makoto Asamoto; K Imaida; S Fukushima; Takehiko Okamura; K Ohtaguro
Primary choriocarcinoma of the urinary bladder.
Japanese journal of clinical oncology 1988;18(1):59-64.
1987: Hiroyuki Tsuda; M A Moore; Makoto Asamoto; T Inoue; S Fukushima; Nobuyuki Ito; K Satoh; Z Amelizad; F Oesch
Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions.
Carcinogenesis 1987;8(5):711-7.
1986: M Hirose; W Thamavit; Makoto Asamoto; T Osawa; N Ito
Inhibition of glutathione S-transferase P type-positive foci development by linolic acid hydroperoxides and their secondary oxidative products in a rat in vivo mid-term test for liver carcinogens.
Toxicology letters 1986;32(1-2):51-8.