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Andrew Hattersley

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Disorders

Chemicals & Drugs

Physiology

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Pedigree

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Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Great Britain

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Publications

TOP 3
Rubio-Cabezas Oscar; Patch Ann-Marie; Minton Jayne A L; Flanagan Sarah E; Edghill Emma L; Hussain Khalid; Balafrej Amina; Deeb Asma; Buchanan Charles R; Jefferson Ian G; Mutair Angham; Hattersley Andrew T; Ellard Sian
Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families.
Shields Beverley M; Freathy Rachel M; Knight Bridget A; Hill Anita; Weedon Michael N; Frayling Timothy M; Hattersley Andrew T; Vaidya Bijay
Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.
McDonald Tim J; Knight Bridget A; Shields Beverley M; Bowman Pamela; Salzmann Maurice B; Hattersley Andrew T
Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide.

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All Publications

2009: Rubio-Cabezas Oscar; Patch Ann-Marie; Minton Jayne A L; Flanagan Sarah E; Edghill Emma L; Hussain Khalid; Balafrej Amina; Deeb Asma; Buchanan Charles R; Jefferson Ian G; Mutair Angham; Hattersley Andrew T; Ellard Sian
Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families.
The Journal of clinical endocrinology and metabolism 2009;94(11):4162-70.
2009: Shields Beverley M; Freathy Rachel M; Knight Bridget A; Hill Anita; Weedon Michael N; Frayling Timothy M; Hattersley Andrew T; Vaidya Bijay
Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.
The Journal of clinical endocrinology and metabolism 2009;94(11):4608-12.
2009: McDonald Tim J; Knight Bridget A; Shields Beverley M; Bowman Pamela; Salzmann Maurice B; Hattersley Andrew T
Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide.
Clinical chemistry 2009;55(11):2035-9.
2009: Rubio-Cabezas O; Edghill E L; Argente J; Hattersley A T
Testing for monogenic diabetes among children and adolescents with antibody-negative clinically defined Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2009;26(10):1070-4.
2009: Perry J R B; Ferrucci L; Bandinelli S; Guralnik J; Semba R D; Rice N; Melzer D; Saxena R; Scott L J; McCarthy M I; Hattersley A T; Zeggini E; Weedon M N; Frayling T M
Circulating beta-carotene levels and type 2 diabetes-cause or effect?
Diabetologia 2009;52(10):2117-21.
2009: Klupa Tomasz; Kowalska Irina; Wyka Krystyna; Skupien Jan; Patch Ann-Marie; Flanagan Sarah E; Noczynska Anna; Arciszewska Malgorzata; Ellard Sian; Hattersley Andrew T; Sieradzki Jacek; Mlynarski Wojciech; Malecki Maciej T
Mutations in the ABCC8 (SUR1 subunit of the K(ATP) channel) gene are associated with a variable clinical phenotype.
Clinical endocrinology 2009;71(3):358-62.
2009: Slingerland A S; Shields B M; Flanagan S E; Bruining G J; Noordam K; Gach A; Mlynarski W; Malecki M T; Hattersley A T; Ellard S
Referral rates for diagnostic testing support an incidence of permanent neonatal diabetes in three European countries of at least 1 in 260,000 live births.
Diabetologia 2009;52(8):1683-5.
2009: Kumaraguru Janani; Flanagan Sarah E; Greeley Siri Atma W; Nuboer Roos; Støy Julie; Philipson Louis H; Hattersley Andrew T; Rubio-Cabezas Oscar
Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect.
Diabetes care 2009;32(8):1428-30.
2009: Freathy Rachel M; Ring Susan M; Shields Beverley; Galobardes Bruna; Knight Beatrice; Weedon Michael N; Smith George Davey; Frayling Timothy M; Hattersley Andrew T
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
Human molecular genetics 2009;18(15):2922-7.
2009: Abdul-Rahman Omar A; Edghill Emma L; Kwan Andrea; Enns Gregory M; Hattersley Andrew T
Hypoplastic glomerulocystic kidney disease and hepatoblastoma: a potential association not caused by mutations in hepatocyte nuclear factor 1beta.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2009;31(7):527-9.
2009: Conn Jennifer J; Simm Peter J; Oats Jeremy J N; Nankervis Alison J; Jacobs Susan E; Ellard Sian; Hattersley Andrew T
Neonatal hyperinsulinaemic hypoglycaemia and monogenic diabetes due to a heterozygous mutation of the HNF4A gene.
The Australian & New Zealand journal of obstetrics & gynaecology 2009;49(3):328-30.
2009: Zhou Kaixin; Donnelly Louise A; Kimber Charlotte H; Donnan Peter T; Doney Alex S F; Leese Graham; Hattersley Andrew T; McCarthy Mark I; Morris Andrew D; Palmer Colin N A; Pearson Ewan R
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
Diabetes 2009;58(6):1434-9.
2009: Perry John R B; McCarthy Mark I; Hattersley Andrew T; Zeggini Eleftheria; Weedon Michael N; Frayling Timothy M
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
Diabetes 2009;58(6):1463-7.
2009: Freathy Rachel M; Bennett Amanda J; Ring Susan M; Shields Beverley; Groves Christopher J; Timpson Nicholas J; Weedon Michael N; Zeggini Eleftheria; Lindgren Cecilia M; Lango Hana; Perry John R B; Pouta Anneli; Ruokonen Aimo; Hyppönen Elina; Power Chris; Elliott Paul; Strachan David P; Järvelin Marjo-Riitta; Smith George Davey; McCarthy Mark I; Frayling Timothy M; Hattersley Andrew T
Type 2 diabetes risk alleles are associated with reduced size at birth.
Diabetes 2009;58(6):1428-33.
2009: Panicker Vijay; Saravanan Ponnusamy; Vaidya Bijay; Evans Jonathan; Hattersley Andrew T; Frayling Timothy M; Dayan Colin M
Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.
The Journal of clinical endocrinology and metabolism 2009;94(5):1623-9.
2009: Timpson Nicholas J; Lindgren Cecilia M; Weedon Michael N; Randall Joshua; Ouwehand Willem H; Strachan David P; Rayner N William; Walker Mark; Hitman Graham A; Doney Alex S F; Palmer Colin N A; Morris Andrew D; Hattersley Andrew T; Zeggini Eleftheria; Frayling Timothy M; McCarthy Mark I
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
Diabetes 2009;58(2):505-10.
2009: Shields Beverley; Hill Anita; Bilous Mary; Knight Beatrice; Hattersley Andrew T; Bilous Rudy W; Vaidya Bijay
Cigarette smoking during pregnancy is associated with alterations in maternal and fetal thyroid function.
The Journal of clinical endocrinology and metabolism 2009;94(2):570-4.
2009: Yajnik C S; Janipalli C S; Bhaskar S; Kulkarni S R; Freathy R M; Prakash S; Mani K R; Weedon M N; Kale S D; Deshpande J; Krishnaveni G V; Veena S R; Fall C H D; McCarthy M I; Frayling T M; Hattersley A T; Chandak G R
FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.
Diabetologia 2009;52(2):247-52.
2009: Spyer G; Macleod K M; Shepherd M; Ellard S; Hattersley A T
Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation.
Diabetic medicine : a journal of the British Diabetic Association 2009;26(1):14-8.
2009: Rubio-Cabezas Oscar; Minton Jayne A L; Caswell Richard; Shield Julian P; Deiss Dorothee; Sumnik Zdenek; Cayssials Amely; Herr Mathias; Loew Anja; Lewis Vaughan; Ellard Sian; Hattersley Andrew T
Clinical heterogeneity in patients with FOXP3 mutations presenting with permanent neonatal diabetes.
Diabetes care 2009;32(1):111-6.
2009: Jafar-Mohammadi Bahram; Groves Christopher J; Owen Katharine R; Frayling Timothy M; Hattersley Andrew T; McCarthy Mark I; Gloyn Anna L
Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
PloS one 2009;4(8):e6615.
2009: Hennig Branwen J; Fulford Anthony J; Sirugo Giorgio; Rayco-Solon Pura; Hattersley Andrew T; Frayling Timothy M; Prentice Andrew M
FTO gene variation and measures of body mass in an African population.
BMC medical genetics 2009;10():21.
2009: Johnson Laura; van Jaarsveld Cornelia H M; Emmett Pauline M; Rogers Imogen S; Ness Andy R; Hattersley Andrew T; Timpson Nicholas J; Smith George Davey; Jebb Susan A
Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants.
PloS one 2009;4(3):e4594.
2008: Rafiq S; Melzer D; Weedon M N; Lango H; Saxena R; Scott L J; Palmer C N A; Morris A D; McCarthy M I; Ferrucci L; Hattersley A T; Zeggini E; Frayling T M
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
Diabetologia 2008;51(12):2205-13.
2008: Della Manna Thais; Battistim Claudilene; Radonsky Vanessa; Savoldelli Roberta D; Damiani Durval; Kok Fernando; Pearson Ewan R; Ellard Sian; Hattersley Andrew T; Reis André F
Glibenclamide unresponsiveness in a Brazilian child with permanent neonatal diabetes mellitus and DEND syndrome due to a C166Y mutation in KCNJ11 (Kir6.2) gene.
Arquivos brasileiros de endocrinologia e metabologia 2008;52(8):1350-5.
2008: McCarthy Mark I; Hattersley Andrew T
Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes.
Diabetes 2008;57(11):2889-98.
2008: Barroso Inês; Luan Jian'an; Wheeler Eleanor; Whittaker Pamela; Wasson Jon; Zeggini Eleftheria; Weedon Michael N; Hunt Sarah; Venkatesh Ranganath; Frayling Timothy M; Delgado Marcos; Neuman Rosalind J; Zhao Jinghua; Sherva Richard; Glaser Benjamin; Walker Mark; Hitman Graham; McCarthy Mark I; Hattersley Andrew T; Permutt M Alan; Wareham Nicholas J; Deloukas Panagiotis
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
Diabetes 2008;57(11):3161-5.
2008: Murphy R; Baptista J; Holly J; Umpleby A M; Ellard S; Harries L W; Crolla J; Cundy T; Hattersley A T
Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene.
The Journal of clinical endocrinology and metabolism 2008;93(11):4373-80.
2008: Lango Hana; Palmer Colin N A; Morris Andrew D; Zeggini Eleftheria; Hattersley Andrew T; McCarthy Mark I; Frayling Timothy M; Weedon Michael N
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
Diabetes 2008;57(11):3129-35.
2008: Timpson Nicholas J; Emmett Pauline M; Frayling Timothy M; Rogers Imogen; Hattersley Andrew T; McCarthy Mark I; Davey Smith George
The fat mass- and obesity-associated locus and dietary intake in children.
The American journal of clinical nutrition 2008;88(4):971-8.
2008: Thomas Christie P; Erlandson Jerold C; Edghill Emma L; Hattersley Andrew T; Stolpen Alan H
A genetic syndrome of chronic renal failure with multiple renal cysts and early onset diabetes.
Kidney international 2008;74(8):1094-9.
2008: Staník Juraj; Lethby Mark; Flanagan Sarah E; Gasperíková Daniela; Milosovicová Beata; Lever Margaret; Bullman Hilary; Zubcevic Lejla; Hattersley Andrew T; Ellard Sian; Ashcroft Frances M; Klimes Iwar
Coincidence of a novel KCNJ11 missense variant R365H with a paternally inherited 6q24 duplication in a patient with transient neonatal diabetes.
Diabetes care 2008;31(9):1736-7.
2008: Mackay Deborah J G; Callaway Jonathan L A; Marks Sophie M; White Helen E; Acerini Carlo L; Boonen Susanne E; Dayanikli Pinar; Firth Helen V; Goodship Judith A; Haemers Andreas P; Hahnemann Johanne M D; Kordonouri Olga; Masoud Ahmed F; Oestergaard Elsebet; Storr John; Ellard Sian; Hattersley Andrew T; Robinson David O; Temple I Karen
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57.
Nature genetics 2008;40(8):949-51.
2008: Panicker Vijay; Cluett Christie; Shields Beverley; Murray Anna; Parnell Kirstie S; Perry John R B; Weedon Michael N; Singleton Andrew; Hernandez Dena; Evans Jonathan; Durant Claire; Ferrucci Luigi; Melzer David; Saravanan Ponnusamy; Visser Theo J; Ceresini Graziano; Hattersley Andrew T; Vaidya Bijay; Dayan Colin M; Frayling Timothy M
A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.
The Journal of clinical endocrinology and metabolism 2008;93(8):3075-81.
2008: Harries Lorna W; Sloman Melissa J; Sellers Elizabeth A C; Hattersley Andrew T; Ellard Sian
Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcripts.
Diabetes 2008;57(7):1978-82.
2008: de Wet Heidi; Proks Peter; Lafond Mathilde; Aittoniemi Jussi; Sansom Mark S P; Flanagan Sarah E; Pearson Ewan R; Hattersley Andrew T; Ashcroft Frances M
A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.
EMBO reports 2008;9(7):648-54.
2008: Harries Lorna W; Locke Jonathan M; Shields Beverley; Hanley Neil A; Hanley Karen Piper; Steele Anna; Njølstad Pål R; Ellard Sian; Hattersley Andrew T
The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development.
Diabetes 2008;57(6):1745-52.
2008: Kapoor Ritika R; Locke Jonathan; Colclough Kevin; Wales Jerry; Conn Jennifer J; Hattersley Andrew T; Ellard Sian; Hussain Khalid
Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations.
Diabetes 2008;57(6):1659-63.
2008: Freathy Rachel M; Timpson Nicholas J; Lawlor Debbie A; Pouta Anneli; Ben-Shlomo Yoav; Ruokonen Aimo; Ebrahim Shah; Shields Beverley; Zeggini Eleftheria; Weedon Michael N; Lindgren Cecilia M; Lango Hana; Melzer David; Ferrucci Luigi; Paolisso Giuseppe; Neville Matthew J; Karpe Fredrik; Palmer Colin N A; Morris Andrew D; Elliott Paul; Jarvelin Marjo-Riitta; Smith George Davey; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
Diabetes 2008;57(5):1419-26.
2008: Murphy Rinki; Ellard Sian; Hattersley Andrew T
Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes.
Nature clinical practice. Endocrinology & metabolism 2008;4(4):200-13.
2008: Ellard S; Bellanné-Chantelot C; Hattersley A T;
Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.
Diabetologia 2008;51(4):546-53.
2008: Murphy R; Turnbull D M; Walker M; Hattersley A T
Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(4):383-99.
2008: Stratigopoulos George; Padilla Stephanie L; LeDuc Charles A; Watson Elizabeth; Hattersley Andrew T; McCarthy Mark I; Zeltser Lori M; Chung Wendy K; Leibel Rudolph L
Regulation of Fto/Ftm gene expression in mice and humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1185-96.
2008: Shields Beverley M; Spyer Gill; Slingerland Annabelle S; Knight Bridget A; Ellard Sian; Clark Penelope M; Hauguel-de Mouzon Sylvie; Hattersley Andrew T
Mutations in the glucokinase gene of the fetus result in reduced placental weight.
Diabetes care 2008;31(4):753-7.
2008: Edghill Emma L; Flanagan Sarah E; Patch Ann-Marie; Boustred Chris; Parrish Andrew; Shields Beverley; Shepherd Maggie H; Hussain Khalid; Kapoor Ritika R; Malecki Maciej; MacDonald Michael J; Støy Julie; Steiner Donald F; Philipson Louis H; Bell Graeme I; Hattersley Andrew T; Ellard Sian
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
Diabetes 2008;57(4):1034-42.
2008: Lawlor Debbie A; Timpson Nicholas J; Harbord Roger M; Leary Sam; Ness Andy; McCarthy Mark I; Frayling Timothy M; Hattersley Andrew T; Smith George Davey
Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable.
PLoS medicine 2008;5(3):e33.
2008: Slingerland A S; Hurkx W; Noordam K; Flanagan S E; Jukema J W; Meiners L C; Bruining G J; Hattersley A T; Hadders-Algra M
Sulphonylurea therapy improves cognition in a patient with the V59M KCNJ11 mutation.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(3):277-81.
2008: Rafiq Meena; Flanagan Sarah E; Patch Ann-Marie; Shields Beverley M; Ellard Sian; Hattersley Andrew T;
Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations.
Diabetes care 2008;31(2):204-9.
2008: Edghill Emma L; Oram Richard A; Owens Martina; Stals Karen L; Harries Lorna W; Hattersley Andrew T; Ellard Sian; Bingham Coralie
Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(2):627-35.
2007: Gill-Carey Olivia; Hattersley Andrew T
Genetics and type 2 diabetes in youth.
Pediatric diabetes 2007;8 Suppl 9():42-7.
2007: Pascoe Laura; Tura Andrea; Patel Sheila K; Ibrahim Ibrahim M; Ferrannini Ele; Zeggini Eleftheria; Weedon Michael N; Mari Andrea; Hattersley Andrew T; McCarthy Mark I; Frayling Timothy M; Walker Mark;
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Diabetes 2007;56(12):3101-4.
2007: de Wet Heidi; Rees Mathew G; Shimomura Kenju; Aittoniemi Jussi; Patch Ann-Marie; Flanagan Sarah E; Ellard Sian; Hattersley Andrew T; Sansom Mark S P; Ashcroft Frances M
Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):18988-92.
2007: Patch A M; Flanagan S E; Boustred C; Hattersley A T; Ellard S
Mutations in the ABCC8 gene encoding the SUR1 subunit of the KATP channel cause transient neonatal diabetes, permanent neonatal diabetes or permanent diabetes diagnosed outside the neonatal period.
Diabetes, obesity & metabolism 2007;9 Suppl 2():28-39.
2007: Ellard S; Thomas K; Edghill E L; Owens M; Ambye L; Cropper J; Little J; Strachan M; Stride A; Ersoy B; Eiberg H; Pedersen O; Shepherd M H; Hansen T; Harries L W; Hattersley A T
Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young.
Diabetologia 2007;50(11):2313-7.
2007: De Silva N M G; Steele A; Shields B; Knight B; Parnell K; Weedon M N; Hattersley A T; Frayling T M
The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(10):1067-72.
2007: Shields Beverley M; Knight Bridget; Hopper Heather; Hill Anita; Powell Roy J; Hattersley Andrew T; Clark Penelope M
Measurement of cord insulin and insulin-related peptides suggests that girls are more insulin resistant than boys at birth.
Diabetes care 2007;30(10):2661-6.
2007: Støy Julie; Edghill Emma L; Flanagan Sarah E; Ye Honggang; Paz Veronica P; Pluzhnikov Anna; Below Jennifer E; Hayes M Geoffrey; Cox Nancy J; Lipkind Gregory M; Lipton Rebecca B; Greeley Siri Atma W; Patch Ann-Marie; Ellard Sian; Steiner Donald F; Hattersley Andrew T; Philipson Louis H; Bell Graeme I;
Insulin gene mutations as a cause of permanent neonatal diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15040-4.
2007: Shimomura K; Hörster F; de Wet H; Flanagan S E; Ellard S; Hattersley A T; Wolf N I; Ashcroft F; Ebinger F
A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.
Neurology 2007;69(13):1342-9.
2007: Hattersley Andrew T
Prime suspect: the TCF7L2 gene and type 2 diabetes risk.
The Journal of clinical investigation 2007;117(8):2077-9.
2007: Ellard Sian; Flanagan Sarah E; Girard Christophe A; Patch Ann-Marie; Harries Lorna W; Parrish Andrew; Edghill Emma L; Mackay Deborah J G; Proks Peter; Shimomura Kenju; Haberland Holger; Carson Dennis J; Shield Julian P H; Hattersley Andrew T; Ashcroft Frances M
Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects.
American journal of human genetics 2007;81(2):375-82.
2007: Sandhu Manjinder S; Weedon Michael N; Fawcett Katherine A; Wasson Jon; Debenham Sally L; Daly Allan; Lango Hana; Frayling Timothy M; Neumann Rosalind J; Sherva Richard; Blech Ilana; Pharoah Paul D; Palmer Colin N A; Kimber Charlotte; Tavendale Roger; Morris Andrew D; McCarthy Mark I; Walker Mark; Hitman Graham; Glaser Benjamin; Permutt M Alan; Hattersley Andrew T; Wareham Nicholas J; Barroso Inês
Common variants in WFS1 confer risk of type 2 diabetes.
Nature genetics 2007;39(8):951-3.
2007: Pearson Ewan R; Donnelly Louise A; Kimber Charlotte; Whitley Adrian; Doney Alex S F; McCarthy Mark I; Hattersley Andrew T; Morris Andrew D; Palmer Colin N A
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
Diabetes 2007;56(8):2178-82.
2007: Singh R; Edghill E; Bingham C; Ellard S; Hattersley A T; Harries L W
Low prevalence of mitochondrial DNA 3243A>G point mutation in Caucasians with unexplained renal disease.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(7):804-6.
2007: Singh R; Hattersley A T; Harries L W
Reduced peripheral blood mitochondrial DNA content is not a risk factor for Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(7):784-7.
2007: Flanagan Sarah E; Patch Ann-Marie; Mackay Deborah J G; Edghill Emma L; Gloyn Anna L; Robinson David; Shield Julian P H; Temple Karen; Ellard Sian; Hattersley Andrew T
Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood.
Diabetes 2007;56(7):1930-7.
2007: Chinnery P F; Mowbray C; Patel S K; Elson J L; Sampson M; Hitman G A; McCarthy M I; Hattersley A T; Walker M
Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.
Journal of medical genetics 2007;44(6):e80.
2007: Freathy Rachel M; Weedon Michael N; Bennett Amanda; Hypponen Elina; Relton Caroline L; Knight Beatrice; Shields Beverley; Parnell Kirstie S; Groves Christopher J; Ring Susan M; Pembrey Marcus E; Ben-Shlomo Yoav; Strachan David P; Power Chris; Jarvelin Marjo-Riitta; McCarthy Mark I; Davey Smith George; Hattersley Andrew T; Frayling Timothy M
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
American journal of human genetics 2007;80(6):1150-61.
2007: Zeggini Eleftheria; Weedon Michael N; Lindgren Cecilia M; Frayling Timothy M; Elliott Katherine S; Lango Hana; Timpson Nicholas J; Perry John R B; Rayner Nigel W; Freathy Rachel M; Barrett Jeffrey C; Shields Beverley; Morris Andrew P; Ellard Sian; Groves Christopher J; Harries Lorna W; Marchini Jonathan L; Owen Katharine R; Knight Beatrice; Cardon Lon R; Walker Mark; Hitman Graham A; Morris Andrew D; Doney Alex S F; McCarthy Mark I; Hattersley Andrew T
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Science (New York, N.Y.) 2007;316(5829):1336-41.
2007: Kimber C H; Doney A S F; Pearson E R; McCarthy M I; Hattersley A T; Leese G P; Morris A D; Palmer C N A
TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
Diabetologia 2007;50(6):1186-91.
2007: Meirhaeghe Aline; Sandhu Manjinder S; McCarthy Mark I; de Groote Pascal; Cottel Dominique; Arveiler Dominique; Ferrières Jean; Groves Christopher J; Hattersley Andrew T; Hitman Graham A; Walker Mark; Wareham Nicholas J; Amouyel Philippe
Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations.
Human molecular genetics 2007;16(11):1343-50.
2007: Gueorguiev Maria; Wiltshire Steven; Garcia Edwin A; Mein Charles; Lecoeur Cecile; Kristen Brigitte; Allotey Rebecca; Hattersley Andrew T; Walker Mark; O'rahilly Stephen; Froguel Philippe; Grossman Ashley B; McCarthy Mark I; Hitman Graham A; Korbonits Márta
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2007;92(6):2201-4.
2007: Melzer David; Frayling Timothy M; Murray Anna; Hurst Alison J; Harries Lorna W; Song Honglin; Khaw Kaytee; Luben Robert; Surtees Paul G; Bandinelli Stefania S; Corsi Anna-Maria; Ferrucci Luigi; Guralnik Jack M; Wallace Robert B; Hattersley Andrew T; Pharoah Paul D
A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
Mechanisms of ageing and development 2007;128(5-6):370-7.
2007: Codner Ethel; Flanagan Sarah E; Ugarte Francisca; García Hernán; Vidal Teresa; Ellard Sian; Hattersley Andrew T
Sulfonylurea treatment in young children with neonatal diabetes: dealing with hyperglycemia, hypoglycemia, and sick days.
Diabetes care 2007;30(5):e28-9.
2007: Edghill Emma L; Gloyn Anna L; Goriely Anne; Harries Lorna W; Flanagan Sarah E; Rankin Julia; Hattersley Andrew T; Ellard Sian
Origin of de novo KCNJ11 mutations and risk of neonatal diabetes for subsequent siblings.
The Journal of clinical endocrinology and metabolism 2007;92(5):1773-7.
2007: Pearson Ewan R; Boj Sylvia F; Steele Anna M; Barrett Timothy; Stals Karen; Shield Julian P; Ellard Sian; Ferrer Jorge; Hattersley Andrew T
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
PLoS medicine 2007;4(4):e118.
2007: Knight Bridget; Shields Beverley M; Hill Anita; Powell Roy J; Wright David; Hattersley Andrew T
The impact of maternal glycemia and obesity on early postnatal growth in a nondiabetic Caucasian population.
Diabetes care 2007;30(4):777-83.
2007: Stanik Juraj; Gasperikova Daniela; Paskova Magdalena; Barak Lubomir; Javorkova Jana; Jancova Emilia; Ciljakova Miriam; Hlava Peter; Michalek Jozef; Flanagan Sarah E; Pearson Ewan; Hattersley Andrew T; Ellard Sian; Klimes Iwar
Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers.
The Journal of clinical endocrinology and metabolism 2007;92(4):1276-82.
2007: Owen Katharine R; Groves Christopher J; Hanson Robert L; Knowler William C; Shuldiner Alan R; Elbein Steven C; Mitchell Braxton D; Froguel Philippe; Ng Maggie C Y; Chan Juliana C; Jia Weiping; Deloukas Panos; Hitman Graham A; Walker Mark; Frayling Timothy M; Hattersley Andrew T; Zeggini Eleftheria; McCarthy Mark I
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.
Diabetes 2007;56(3):879-83.
2007: Winckler Wendy; Weedon Michael N; Graham Robert R; McCarroll Steven A; Purcell Shaun; Almgren Peter; Tuomi Tiinamaija; Gaudet Daniel; Boström Kristina Bengtsson; Walker Mark; Hitman Graham; Hattersley Andrew T; McCarthy Mark I; Ardlie Kristin G; Hirschhorn Joel N; Daly Mark J; Frayling Timothy M; Groop Leif; Altshuler David
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
Diabetes 2007;56(3):685-93.
2007: Singh R; Pearson E R; Clark P M; Hattersley A T
The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations.
Diabetologia 2007;50(3):620-4.
2007: Desai M; Zeggini E; Horton V A; Owen K R; Hattersley A T; Levy J C; Walker M; Gillespie K M; Bingley P J; Hitman G A; Holman R R; McCarthy M I; Clark A
An association analysis of the HLA gene region in latent autoimmune diabetes in adults.
Diabetologia 2007;50(1):68-73.
2007: Chandak G R; Janipalli C S; Bhaskar S; Kulkarni S R; Mohankrishna P; Hattersley A T; Frayling T M; Yajnik C S
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
Diabetologia 2007;50(1):63-7.
2006: Hattersley Andrew; Bruining Jan; Shield Julian; Njolstad Pal; Donaghue Kim;
ISPAD Clinical Practice Consensus Guidelines 2006-2007. The diagnosis and management of monogenic diabetes in children.
Pediatric diabetes 2006;7(6):352-60.
2006: Craig Maria E; Hattersley Andrew; Donaghue Kim;
ISPAD Clinical Practice Consensus Guidelines 2006-2007. Definition, epidemiology and classification.
Pediatric diabetes 2006;7(6):343-51.
2006: Weedon Michael N; Clark Vanessa J; Qian Yudong; Ben-Shlomo Yoav; Timpson Nicholas; Ebrahim Shah; Lawlor Debbie A; Pembrey Marcus E; Ring Susan; Wilkin Terry J; Voss Linda D; Jeffery Alison N; Metcalf Brad; Ferrucci Luigi; Corsi Anna Maria; Murray Anna; Melzer David; Knight Bridget; Shields Bev; Smith George Davey; Hattersley Andrew T; Di Rienzo Anna; Frayling Tim M
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.
American journal of human genetics 2006;79(6):991-1001.
2006: Edghill E L; Bingham C; Slingerland A S; Minton J A L; Noordam C; Ellard S; Hattersley A T
Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(12):1301-6.
2006: Weedon Michael N; Shields Beverley; Hitman Graham; Walker Mark; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
Diabetes 2006;55(11):3175-9.
2006: Tarasov Andrei I; Welters Hannah J; Senkel Sabine; Ryffel Gerhart U; Hattersley Andrew T; Morgan Noel G; Ashcroft Frances M
A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells.
Diabetes 2006;55(11):3075-82.
2006: Stenhouse E; Wright D E; Hattersley A T; Millward B A
Maternal glucose levels influence birthweight and 'catch-up' and 'catch-down' growth in a large contemporary cohort.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(11):1207-12.
2006: Slingerland A S; Nuboer R; Hadders-Algra M; Hattersley A T; Bruining G J
Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation in the KCNJ11 gene.
Diabetologia 2006;49(11):2559-63.
2006: Wiltshire S; Bell J T; Groves C J; Dina C; Hattersley A T; Frayling T M; Walker M; Hitman G A; Vaxillaire M; Farrall M; Froguel P; McCarthy M I
Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
Annals of human genetics 2006;70(Pt 6):726-37.
2006: Knight B; Shields B M; Hill A; Powell R J; Round A; Hamilton W; Hattersley A T
Offspring birthweight is not associated with paternal insulin resistance.
Diabetologia 2006;49(11):2675-8.
2006: Shields B M; Knight B; Turner M; Wilkins-Wall B; Shakespeare L; Powell R J; Hannemann M; Clark P M; Yajnik C S; Hattersley A T
Paternal insulin resistance and its association with umbilical cord insulin concentrations.
Diabetologia 2006;49(11):2668-74.
2006: Weedon Michael N; McCarthy Mark I; Hitman Graham; Walker Mark; Groves Christopher J; Zeggini Eleftheria; Rayner N William; Shields Beverley; Owen Katharine R; Hattersley Andrew T; Frayling Timothy M
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
PLoS medicine 2006;3(10):e374.
2006: Groves Christopher J; Zeggini Eleftheria; Minton Jayne; Frayling Timothy M; Weedon Michael N; Rayner Nigel W; Hitman Graham A; Walker Mark; Wiltshire Steven; Hattersley Andrew T; McCarthy Mark I
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
Diabetes 2006;55(9):2640-4.
2006: Zeggini Eleftheria; Damcott Coleen M; Hanson Robert L; Karim Mohammad A; Rayner N William; Groves Christopher J; Baier Leslie J; Hale Terri C; Hattersley Andrew T; Hitman Graham A; Hunt Sarah E; Knowler William C; Mitchell Braxton D; Ng Maggie C Y; O'Connell Jeffrey R; Pollin Toni I; Vaxillaire Martine; Walker Mark; Wang Xiaoqin; Whittaker Pamela; Xiang Kunsan; Jia Weiping; Chan Juliana C N; Froguel Philippe; Deloukas Panos; Shuldiner Alan R; Elbein Steven C; McCarthy Mark I;
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.
Diabetes 2006;55(9):2541-8.
2006: Castleden H A J; Shields B; Bingley P J; Williams A J K; Sampson M; Walker M; Gibson J M; McCarthy M I; Hitman G A; Levy J C; Hattersley A T; Vaidya B; Pearson E R
GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(8):834-8.
2006: Pearson Ewan R; Flechtner Isabelle; Njølstad Pål R; Malecki Maciej T; Flanagan Sarah E; Larkin Brian; Ashcroft Frances M; Klimes Iwar; Codner Ethel; Iotova Violeta; Slingerland Annabelle S; Shield Julian; Robert Jean-Jacques; Holst Jens J; Clark Penny M; Ellard Sian; Søvik Oddmund; Polak Michel; Hattersley Andrew T;
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
The New England journal of medicine 2006;355(5):467-77.
2006: Gloyn Anna L; Mackay Deborah J G; Weedon Michael N; McCarthy Mark I; Walker Mark; Hitman Graham; Knight Bridget A; Owen Katharine R; Hattersley Andrew T; Frayling Timothy M
Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
Diabetes 2006;55(8):2272-6.
2006: Singh R; Pearson E; Avery P J; McCarthy M I; Levy J C; Hitman G A; Sampson M; Walker M; Hattersley A T
Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.
Diabetologia 2006;49(8):1876-80.
2006: Welters Hannah J; Senkel Sabine; Klein-Hitpass Ludger; Erdmann Silke; Thomas Heike; Harries Lorna W; Pearson Ewan R; Bingham Coralie; Hattersley Andrew T; Ryffel Gerhart U; Morgan Noel G
Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.
The Journal of endocrinology 2006;190(1):171-81.
2006: Harries Lorna W; Ellard Sian; Stride Amanda; Morgan Noel G; Hattersley Andrew T
Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.
Human molecular genetics 2006;15(14):2216-24.
2006: Gloyn Anna L; Diatloff-Zito Catherine; Edghill Emma L; Bellanné-Chantelot Christine; Nivot Sylvie; Coutant Régis; Ellard Sian; Hattersley Andrew T; Robert Jean Jacques
KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features.
European journal of human genetics : EJHG 2006;14(7):824-30.
2006: Slingerland Annabelle S; Hattersley Andrew T
Activating mutations in the gene encoding Kir6.2 alter fetal and postnatal growth and also cause neonatal diabetes.
The Journal of clinical endocrinology and metabolism 2006;91(7):2782-8.
2006: Spyer Gill; Ellard Sian; Turnpenny Peter D; Hattersley Andrew T; Vaidya Bijay
Phenotypic multiple endocrine neoplasia type 2B, without endocrinopathy or RET gene mutation: implications for management.
Thyroid : official journal of the American Thyroid Association 2006;16(6):605-8.
2006: Edghill Emma L; Dix Rachel J; Flanagan Sarah E; Bingley Polly J; Hattersley Andrew T; Ellard Sian; Gillespie Kathleen M
HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 months.
Diabetes 2006;55(6):1895-8.
2006: Desai Minal; Zeggini Eleftheria; Horton Virginia A; Owen Katharine R; Hattersley Andrew T; Levy Jonathan C; Hitman Graham A; Walker Mark; Holman Rury R; McCarthy Mark I; Clark Anne
The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
Diabetes 2006;55(6):1890-4.
2006: Groves Christopher J; Zeggini Eleftheria; Walker Mark; Hitman Graham A; Levy Jonathan C; O'Rahilly Stephen; Hattersley Andrew T; McCarthy Mark I; Wiltshire Steven
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Diabetes 2006;55(6):1884-9.
2006: Shimomura Kenju; Girard Christophe A J; Proks Peter; Nazim Joanna; Lippiat Jonathan D; Cerutti Franco; Lorini Renata; Ellard Sian; Hattersley Andrew T; Barbetti Fabrizio; Ashcroft Frances M
Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.
Diabetes 2006;55(6):1705-12.
2006: Proks Peter; Arnold Amanda L; Bruining Jan; Girard Christophe; Flanagan Sarah E; Larkin Brian; Colclough Kevin; Hattersley Andrew T; Ashcroft Frances M; Ellard Sian
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.
Human molecular genetics 2006;15(11):1793-800.
2006: Flanagan S E; Edghill E L; Gloyn A L; Ellard S; Hattersley A T
Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype.
Diabetologia 2006;49(6):1190-7.
2006: Patel S; Minton J A L; Weedon M N; Frayling T M; Ricketts C; Hitman G A; McCarthy M I; Hattersley A T; Walker M; Barrett T G
Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Diabetologia 2006;49(6):1209-13.
2006: Hattersley Andrew T; Pearson Ewan R
Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes.
Endocrinology 2006;147(6):2657-63.
2006: Singh Rinki; Ellard Sian; Hattersley Andrew; Harries Lorna W
Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation.
The Journal of molecular diagnostics : JMD 2006;8(2):225-30.
2006: Knight Bridget; Shields Beverley M; Hattersley Andrew T
The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology.
Paediatric and perinatal epidemiology 2006;20(2):172-9.
2006: Brackenridge Anna; Pearson Ewan R; Shojaee-Moradie Fariba; Hattersley Andrew T; Russell-Jones David; Umpleby A Margot
Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations.
Diabetes 2006;55(2):405-11.
2006: Donnelly L A; Doney A S F; Hattersley A T; Morris A D; Pearson E R
The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(2):128-33.
2006: Shields B M; Knight B; Shakespeare L; Babrah J; Powell R J; Clark P M; Hattersley A T
Determinants of insulin concentrations in healthy 1-week-old babies in the community: applications of a bloodspot assay.
Early human development 2006;82(2):143-8.
2006: Hattersley Andrew T
Beyond the beta cell in diabetes.
Nature genetics 2006;38(1):12-3.
2006: Edghill E L; Bingham C; Ellard S; Hattersley A T
Mutations in hepatocyte nuclear factor-1beta and their related phenotypes.
Journal of medical genetics 2006;43(1):84-90.
2006: Freathy Rachel M; Lonnen Kathryn F; Steele Anna M; Minton Jayne A L; Frayling Timothy M; Hattersley Andrew T; Macleod Kenneth M
The impact of the angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycemia in Type 2 diabetes.
The review of diabetic studies : RDS 2006;3(2):76-81.
2006: Freathy Rachel M; Mitchell Simon M S; Knight Beatrice; Shields Beverley; Weedon Michael N; Hattersley Andrew T; Frayling Timothy M
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Journal of negative results in biomedicine 2006;5():18.
2006: Chandak Giriraj R; Ward Kirsten J; Yajnik Chittaranjan S; Pandit Anand N; Bavdekar Ashish; Joglekar Charu V; Fall Caroline H D; Mohankrishna P; Wilkin Terence J; Metcalf Bradley S; Weedon Michael N; Frayling Timothy M; Hattersley Andrew T
Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans.
BMC medical genetics 2006;7():76.
2006: Shields Beverley M; Knight Bridget A; Powell Roy J; Hattersley Andrew T; Wright David E
Assessing newborn body composition using principal components analysis: differences in the determinants of fat and skeletal size.
BMC pediatrics 2006;6():24.
2006: Freathy Rachel M; Weedon Michael N; Melzer David; Shields Beverley; Hitman Graham A; Walker Mark; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
BMC medical genetics 2006;7():51.
2006: Freathy Rachel M; Weedon Michael N; Shields Beverley; Hitman Graham A; Walker Mark; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
JOP : Journal of the pancreas 2006;7(3):295-302.
2006: Ward Kirsten J; Ellard Sian; Yajnik Chittaranjan S; Frayling Timothy M; Hattersley Andrew T; Venigalla Prathyusha N S; Chandak Giriraj R
Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene.
Lipids in health and disease 2006;5():11.
2005: Zeggini E; Parkinson J R C; Halford S; Owen K R; Walker M; Hitman G A; Levy J C; Sampson M J; Frayling T M; Hattersley A T; McCarthy M I
Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(12):1696-700.
2005: Timpson Nicholas J; Lawlor Debbie A; Harbord Roger M; Gaunt Tom R; Day Ian N M; Palmer Lyle J; Hattersley Andrew T; Ebrahim Shah; Lowe Gordon D O; Rumley Ann; Davey Smith George
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study.
Lancet 2005;366(9501):1954-9.
2005: Zeggini Eleftheria; Rayner William; Morris Andrew P; Hattersley Andrew T; Walker Mark; Hitman Graham A; Deloukas Panos; Cardon Lon R; McCarthy Mark I
An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.
Nature genetics 2005;37(12):1320-2.
2005: Fava Stephen; Hattersley Andrew T
Reported parental age of death in type 2 diabetic patients with and without established diabetic nephropathy.
European journal of internal medicine 2005;16(7):482-4.
2005: Chinnery P F; Elliott H R; Patel S; Lambert C; Keers S M; Durham S E; McCarthy M I; Hitman G A; Hattersley A T; Walker M
Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.
Lancet 2005;366(9497):1650-1.
2005: Harries L W; Bingham Coralie; Bellanne-Chantelot Christine; Hattersley A T; Ellard Sian
The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay.
Human genetics 2005;118(2):214-24.
2005: Hattersley Andrew T; McCarthy Mark I
What makes a good genetic association study?
Lancet 2005;366(9493):1315-23.
2005: Zeggini E; Groves C J; Parkinson J R C; Halford S; Owen K R; Frayling T M; Walker M; Hitman G A; Levy J C; O'Rahilly S; Hattersley A T; McCarthy M I
Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
Diabetologia 2005;48(10):2013-7.
2005: Knight Bridget; Shields Beverley M; Turner Martina; Powell Roy J; Yajnik Chittaranjan S; Hattersley Andrew T
Evidence of genetic regulation of fetal longitudinal growth.
Early human development 2005;81(10):823-31.
2005: Hattersley Andrew T
Molecular genetics goes to the diabetes clinic.
Clinical medicine (London, England) 2005;5(5):476-81.
2005: Hattersley Andrew T; Ashcroft Frances M
Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy.
Diabetes 2005;54(9):2503-13.
2005: Weedon Michael N; Owen Katharine R; Shields Beverley; Hitman Graham; Walker Mark; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Diabetes 2005;54(8):2487-91.
2005: Stride Amanda; Ellard Sian; Clark Penny; Shakespeare Lynette; Salzmann Maurice; Shepherd Maggie; Hattersley Andrew T
Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.
Diabetes care 2005;28(7):1751-6.
2005: Schnyder Sabine; Mullis Primus E; Ellard Sian; Hattersley Andrew T; Flück Christa E
Genetic testing for glucokinase mutations in clinically selected patients with MODY: a worthwhile investment.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology 2005;135(23-24):352-6.
2005: Proks Peter; Girard Christophe; Haider Shozeb; Gloyn Anna L; Hattersley Andrew T; Sansom Mark S P; Ashcroft Frances M
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.
EMBO reports 2005;6(5):470-5.
2005: Klupa T; Edghill E L; Nazim J; Sieradzki J; Ellard S; Hattersley A T; Malecki M T
The identification of a R201H mutation in KCNJ11, which encodes Kir6.2, and successful transfer to sustained-release sulphonylurea therapy in a subject with neonatal diabetes: evidence for heterogeneity of beta cell function among carriers of the R201H mutation.
Diabetologia 2005;48(5):1029-31.
2005: Pearson E R; Pruhova S; Tack C J; Johansen A; Castleden H A J; Lumb P J; Wierzbicki A S; Clark P M; Lebl J; Pedersen O; Ellard S; Hansen T; Hattersley A T
Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.
Diabetologia 2005;48(5):878-85.
2005: Sagen J V; Pearson E R; Johansen A; Spyer G; Søvik O; Pedersen O; Njølstad P R; Hattersley A T; Hansen T
Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(4):406-9.
2005: Gloyn Anna L; Reimann Frank; Girard Christophe; Edghill Emma L; Proks Peter; Pearson Ewan R; Temple I Karen; Mackay Deborah J G; Shield Julian P H; Freedenberg Debra; Noyes Kathryn; Ellard Sian; Ashcroft Frances M; Gribble Fiona M; Hattersley Andrew T
Relapsing diabetes can result from moderately activating mutations in KCNJ11.
Human molecular genetics 2005;14(7):925-34.
2005: Gloyn Anna L; Odili Stella; Zelent Dorothy; Buettger Carol; Castleden Harriet A J; Steele Anna M; Stride Amanda; Shiota Chyio; Magnuson Mark A; Lorini Renata; d'Annunzio Giuseppe; Stanley Charles A; Kwagh Jae; van Schaftingen Emile; Veiga-da-Cunha Maria; Barbetti Fabrizio; Dunten Pete; Han Yi; Grimsby Joseph; Taub Rebecca; Ellard Sian; Hattersley Andrew T; Matschinsky Franz M
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
The Journal of biological chemistry 2005;280(14):14105-13.
2005: Codner Ethel; Flanagan Sarah; Ellard Sian; García Hernán; Hattersley Andrew T
High-dose glibenclamide can replace insulin therapy despite transitory diarrhea in early-onset diabetes caused by a novel R201L Kir6.2 mutation.
Diabetes care 2005;28(3):758-9.
2005: Weedon Michael N; Frayling Timothy M; Shields Beverley; Knight Beatrice; Turner Tina; Metcalf Bradley S; Voss Linda; Wilkin Terence J; McCarthy Anne; Ben-Shlomo Yoav; Davey Smith George; Ring Sue; Jones Richard; Golding Jean; Byberg Liisa; Mann Vera; Axelsson Tomas; Syvänen Ann-Christine; Leon David; Hattersley Andrew T
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Diabetes 2005;54(2):576-81.
2005: Ellard S; Hattersley A T; Brewer C M; Vaidya B
Detection of an MEN1 gene mutation depends on clinical features and supports current referral criteria for diagnostic molecular genetic testing.
Clinical endocrinology 2005;62(2):169-75.
2005: Massa Ornella; Iafusco Dario; D'Amato Elena; Gloyn Anna L; Hattersley Andrew T; Pasquino Bruno; Tonini Giorgio; Dammacco Francesco; Zanette Giorgio; Meschi Franco; Porzio Ottavia; Bottazzo Gianfranco; Crinó Antonino; Lorini Renata; Cerutti Franco; Vanelli Maurizio; Barbetti Fabrizio;
KCNJ11 activating mutations in Italian patients with permanent neonatal diabetes.
Human mutation 2005;25(1):22-7.
2005: Slingerland Annabelle S; Hattersley Andrew T
Mutations in the Kir6.2 subunit of the KATP channel and permanent neonatal diabetes: new insights and new treatment.
Annals of medicine 2005;37(3):186-95.
2005: Maeda Shiro; Tsukada Shuichi; Kanazawa Akio; Sekine Akihiro; Tsunoda Tatsuhiko; Koya Daisuke; Maegawa Hiroshi; Kashiwagi Atsunori; Babazono Tetsuya; Matsuda Masafumi; Tanaka Yasushi; Fujioka Tomoaki; Hirose Hiroshi; Eguchi Takashi; Ohno Yoichi; Groves Christopher J; Hattersley Andrew T; Hitman Graham A; Walker Mark; Kaku Kohei; Iwamoto Yasuhiko; Kawamori Ryuzo; Kikkawa Ryuichi; Kamatani Naoyuki; McCarthy Mark I; Nakamura Yusuke
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.
Journal of human genetics 2005;50(6):283-92.
2004: Liew C F; Groves C J; Wiltshire S; Zeggini E; Frayling T M; Owen K R; Walker M; Hitman G A; Levy J C; O'rahilly S; Hattersley A T; Johnston D G; McCarthy M I
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
Diabetologia 2004;47(12):2168-75.
2004: Proks Peter; Antcliff Jennifer F; Lippiat Jon; Gloyn Anna L; Hattersley Andrew T; Ashcroft Frances M
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17539-44.
2004: Zeggini Eleftheria; Parkinson James; Halford Stephanie; Owen Katharine R; Frayling Timothy M; Walker Mark; Hitman Graham A; Levy Jonathan C; Sampson Mike J; Feskens Edith J M; Hattersley Andrew T; McCarthy Mark I
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Diabetes 2004;53(12):3319-22.
2004: Sellick Gabrielle S; Barker Karen T; Stolte-Dijkstra Irene; Fleischmann Christina; Coleman Richard J; Garrett Christine; Gloyn Anna L; Edghill Emma L; Hattersley Andrew T; Wellauer Peter K; Goodwin Graham; Houlston Richard S
Mutations in PTF1A cause pancreatic and cerebellar agenesis.
Nature genetics 2004;36(12):1301-5.
2004: Weedon Michael N; Owen Katharine R; Shields Beverley; Hitman Graham; Walker Mark; McCarthy Mark I; Love-Gregory Latisha D; Permutt M Alan; Hattersley Andrew T; Frayling Timothy M
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Diabetes 2004;53(11):3002-6.
2004: Edghill Emma L; Gloyn Anna L; Gillespie Kathleen M; Lambert A Paul; Raymond Neil T; Swift Peter G; Ellard Sian; Gale Edwin A M; Hattersley Andrew T
Activating mutations in the KCNJ11 gene encoding the ATP-sensitive K+ channel subunit Kir6.2 are rare in clinically defined type 1 diabetes diagnosed before 2 years.
Diabetes 2004;53(11):2998-3001.
2004: Bingham Coralie; Hattersley Andrew T
Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor-1beta.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(11):2703-8.
2004: Vaxillaire Martine; Populaire Céline; Busiah Kanetee; Cavé Hélène; Gloyn Anna L; Hattersley Andrew T; Czernichow Paul; Froguel Philippe; Polak Michel
Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients.
Diabetes 2004;53(10):2719-22.
2004: Sagen Jørn V; Raeder Helge; Hathout Eba; Shehadeh Naim; Gudmundsson Kolbeinn; Baevre Halvor; Abuelo Dianne; Phornphutkul Chanika; Molnes Janne; Bell Graeme I; Gloyn Anna L; Hattersley Andrew T; Molven Anders; Søvik Oddmund; Njølstad Pål R
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.
Diabetes 2004;53(10):2713-8.
2004: Stenhouse E; Wright D E; Hattersley A T; Millward B A
Weight differences in Plymouth toddlers compared to the British Growth Reference Population.
Archives of disease in childhood 2004;89(9):843-4.
2004: Stenhouse Elizabeth; Wright David E; Hattersley Andrew T; Millward Ann
The accuracy of birth weight.
Journal of clinical nursing 2004;13(6):767-8.
2004: Gloyn Anna L; Cummings Elizabeth A; Edghill Emma L; Harries Lorna W; Scott Rachel; Costa Teresa; Temple I Karen; Hattersley Andrew T; Ellard Sian
Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel.
The Journal of clinical endocrinology and metabolism 2004;89(8):3932-5.
2004: Hattersley Andrew T
Unlocking the secrets of the pancreatic beta cell: man and mouse provide the key.
The Journal of clinical investigation 2004;114(3):314-6.
2004: Stride A; Pearson E R; Brown A; Gooding K; Castleden H A J; Hattersley A T
Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(8):928-30.
2004: Burren Christine P; Hattersley Andrew T
Remitting diabetes: a new genetic subgroup?
Diabetes care 2004;27(7):1836.
2004: Dobson L; Sheldon C D; Hattersley A T
Conventional measures underestimate glycaemia in cystic fibrosis patients.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(7):691-6.
2004: Vaidya Bijay; Campbell Viv; Tripp John H; Spyer Gill; Hattersley Andrew T; Ellard Sian
Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.
Clinical endocrinology 2004;60(6):711-8.
2004: Ehtisham S; Hattersley A T; Dunger D B; Barrett T G;
First UK survey of paediatric type 2 diabetes and MODY.
Archives of disease in childhood 2004;89(6):526-9.
2004: Pearson Ewan R; Badman Michael K; Lockwood Christopher R; Clark Penelope M; Ellard Sian; Bingham Coralie; Hattersley Andrew T
Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.
Diabetes care 2004;27(5):1102-7.
2004: Harries L W; Ellard S; Jones R W A; Hattersley A T; Bingham C
Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome.
Diabetologia 2004;47(5):937-42.
2004: Mills G W; Avery P J; McCarthy M I; Hattersley A T; Levy J C; Hitman G A; Sampson M; Walker M
Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
Diabetologia 2004;47(4):732-8.
2004: Gloyn Anna L; Pearson Ewan R; Antcliff Jennifer F; Proks Peter; Bruining G Jan; Slingerland Annabelle S; Howard Neville; Srinivasan Shubha; Silva José M C L; Molnes Janne; Edghill Emma L; Frayling Timothy M; Temple I Karen; Mackay Deborah; Shield Julian P H; Sumnik Zdenek; van Rhijn Adrian; Wales Jerry K H; Clark Penelope; Gorman Shaun; Aisenberg Javier; Ellard Sian; Njølstad Pål R; Ashcroft Frances M; Hattersley Andrew T
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
The New England journal of medicine 2004;350(18):1838-49.
2004: Shepherd Maggie; Hattersley Andrew T
'I don't feel like a diabetic any more': the impact of stopping insulin in patients with maturity onset diabetes of the young following genetic testing.
Clinical medicine (London, England) 2004;4(2):144-7.
2004: Wiltshire Steven; Frayling Timothy M; Groves Christopher J; Levy Jonathan C; Hitman Graham A; Sampson Mike; Walker Mark; Menzel Stephan; Hattersley Andrew T; Cardon Lon R; McCarthy Mark I
Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
Diabetes 2004;53(3):855-60.
2004: Harries Lorna W; Hattersley Andrew T; Ellard Sian
Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay.
Diabetes 2004;53(2):500-4.
2004: Mitchell Simon M S; Hattersley Andrew T; Knight Beatrice; Turner Tina; Metcalf Bradley S; Voss Linda D; Davies David; McCarthy Anne; Wilkin Terence J; Smith George Davey; Ben-Shlomo Yoav; Frayling Timothy M
Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations.
The Journal of clinical endocrinology and metabolism 2004;89(1):310-7.
2004: Weedon Michael N; Hattersley Andrew T; Frayling Timothy M
Tall stories: the fundamental difficulties of genetic association studies.
Clinical endocrinology 2004;60(1):145-6.
2004: Dobson Lee; Sheldon Christopher D; Hattersley Andrew T
Understanding cystic-fibrosis-related diabetes: best thought of as insulin deficiency?
Journal of the Royal Society of Medicine 2004;97 Suppl 44():26-35.
2004: Owen Katharine R; Donohoe Mollie; Ellard Sian; Clarke Tom J; Nicholls Anthony J; Hattersley Andrew T; Bingham Coralie
Mesangiocapillary glomerulonephritis type 2 associated with familial partial lipodystrophy (Dunnigan-Kobberling syndrome).
Nephron. Clinical practice 2004;96(2):c35-8.
2003: Richter Symi; Shih David Q; Pearson Ewan R; Wolfrum Christian; Fajans Stefan S; Hattersley Andrew T; Stoffel Markus
Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels.
Diabetes 2003;52(12):2989-95.
2003: Ward Kirsten J; Shields Beverley; Knight Beatrice; Salzmann Maurice B; Hattersley Andrew T; Frayling Timothy M
Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy.
Lipids in health and disease 2003;2():9.
2003: Shepherd Maggie; Pearson Ewan R; Houghton Jane; Salt Gill; Ellard Sian; Hattersley Andrew T
No deterioration in glycemic control in HNF-1alpha maturity-onset diabetes of the young following transfer from long-term insulin to sulphonylureas.
Diabetes care 2003;26(11):3191-2.
2003: Weedon Michael N; Schwarz Peter E H; Horikawa Yukio; Iwasaki Naoko; Illig Thomas; Holle Rolf; Rathmann Wolfgang; Selisko Thomas; Schulze Jan; Owen Katherine R; Evans Julie; Del Bosque-Plata Laura; Hitman Graham; Walker Mark; Levy Jonathan C; Sampson Mike; Bell Graeme I; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
American journal of human genetics 2003;73(5):1208-12.
2003: Thomson K L; Gloyn A L; Colclough K; Batten M; Allen L I S; Beards F; Hattersley A T; Ellard S
Identification of 21 novel glucokinase (GCK) mutations in UK and European Caucasians with maturity-onset diabetes of the young (MODY).
Human mutation 2003;22(5):417.
2003: Pearson Ewan R; Starkey Bryan J; Powell Roy J; Gribble Fiona M; Clark Penny M; Hattersley Andrew T
Genetic cause of hyperglycaemia and response to treatment in diabetes.
Lancet 2003;362(9392):1275-81.
2003: Owen Katharine R; Donohoe Mollie; Ellard Sian; Hattersley Andrew T
Response to treatment with rosiglitazone in familial partial lipodystrophy due to a mutation in the LMNA gene.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(10):823-7.
2003: Gloyn Anna L; Noordam Kees; Willemsen Michèl A A P; Ellard Sian; Lam Wayne W K; Campbell Ian W; Midgley Paula; Shiota Chyio; Buettger Carol; Magnuson Mark A; Matschinsky Franz M; Hattersley Andrew T
Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
Diabetes 2003;52(9):2433-40.
2003: Bohn Silvia; Thomas Heike; Turan Gülüzar; Ellard Sian; Bingham Coralie; Hattersley Andrew T; Ryffel Gerhart U
Distinct molecular and morphogenetic properties of mutations in the human HNF1beta gene that lead to defective kidney development.
Journal of the American Society of Nephrology : JASN 2003;14(8):2033-41.
2003: Demenais Florence; Kanninen Timo; Lindgren Cecilia M; Wiltshire Steven; Gaget Stéphane; Dandrieux Candice; Almgren Peter; Sjögren Marketa; Hattersley Andrew; Dina Christian; Tuomi Tiinamaija; McCarthy Mark I; Froguel Philippe; Groop Leif C
A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.
Human molecular genetics 2003;12(15):1865-73.
2003: Weedon Michael N; Turner Martina; Knight Beatrice; Clark Penny; Hattersley Andrew T; Frayling Timothy M
Variants in the aromatase gene and on the Y-chromosome are not associated with adult height or insulin resistance in a UK population.
Clinical endocrinology 2003;59(2):175-9.
2003: Owen Katharine R; Stride Amanda; Ellard Sian; Hattersley Andrew T
Etiological investigation of diabetes in young adults presenting with apparent type 2 diabetes.
Diabetes care 2003;26(7):2088-93.
2003: Frayling Timothy M; Wiltshire Steven; Hitman Graham A; Walker Mark; Levy Jonathan C; Sampson Mike; Groves Christopher J; Menzel Stephan; McCarthy Mark I; Hattersley Andrew T
Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
Diabetes 2003;52(7):1857-63.
2003: Stenhouse Elizabeth; Wright David; Hattersley Andrew; Millward Ann
How well do midwives estimate the date of delivery?
Midwifery 2003;19(2):125-31.
2003: Owen K R; Roland J; Smith K; Hattersley A T
Adolescent onset Type 2 diabetes in a non-obese Caucasian patient with an unbalanced translocation.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(6):483-5.
2003: Dobson Lee; Sheldon Christopher D; Hattersley Andrew T
Validation of interstitial fluid continuous glucose monitoring in cystic fibrosis.
Diabetes care 2003;26(6):1940-1.
2003: Groves Christopher J; Wiltshire Steven; Smedley Damian; Owen Katherine R; Frayling Timothy M; Walker Mark; Hitman Graham A; Levy Jonathan C; O'Rahilly Stephen; Menzel Stephan; Hattersley Andrew T; McCarthy Mark I
Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
Diabetes 2003;52(5):1300-5.
2003: Mitchell Simon M S; Weedon Michael N; Owen Katharine R; Shields Beverley; Wilkins-Wall Beverley; Walker Mark; McCarthy Mark I; Frayling Timothy M; Hattersley Andrew T
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
Diabetes 2003;52(5):1276-9.
2003: Jafar Tazeen H; Levey Andrew S; Jafary Fahim H; White Franklin; Gul Asma; Rahbar Mohammad H; Khan Abdul Q; Hattersley Andrew; Schmid Christopher H; Chaturvedi Nish
Ethnic subgroup differences in hypertension in Pakistan.
Journal of hypertension 2003;21(5):905-12.
2003: Bingham Coralie; Ellard Sian; van't Hoff William G; Simmonds H Anne; Marinaki Anthony M; Badman Michael K; Winocour Peter H; Stride Amanda; Lockwood Christopher R; Nicholls Anthony J; Owen Katharine R; Spyer Ghislaine; Pearson Ewan R; Hattersley Andrew T
Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation.
Kidney international 2003;63(5):1645-51.
2003: Frayling Timothy M; Lindgren Cecilia M; Chevre Jean Claude; Menzel Stephan; Wishart Marie; Benmezroua Yamina; Brown Alison; Evans Julie C; Rao Pamidghantam Subba; Dina Christian; Lecoeur Cécile; Kanninen Timo; Almgren Peter; Bulman Michael P; Wang Youxiang; Mills James; Wright-Pascoe Rosemarie; Mahtani Melanie M; Prisco Francesco; Costa Angels; Cognet Ignacio; Hansen Torben; Pedersen Oluf; Ellard Sian; Tuomi Tiinamaija; Groop Leif C; Froguel Philippe; Hattersley Andrew T; Vaxillaire Martine
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Diabetes 2003;52(3):872-81.
2003: Lambert A Paul; Ellard Sian; Allen Lisa I S; Gallen Ian W; Gillespie Kathleen M; Bingley Polly J; Hattersley Andrew T
Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetes.
Diabetes care 2003;26(2):333-7.
2003: Gloyn Anna L; Weedon Michael N; Owen Katharine R; Turner Martina J; Knight Bridget A; Hitman Graham; Walker Mark; Levy Jonathan C; Sampson Mike; Halford Stephanie; McCarthy Mark I; Hattersley Andrew T; Frayling Timothy M
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Diabetes 2003;52(2):568-72.
2003: Ferguson Stewart C; Deary Ian J; Perros Petros; Evans Julie C; Ellard Sian; Hattersley Andrew T; Frier Brian M
Apolipoprotein-e influences aspects of intellectual ability in type 1 diabetes.
Diabetes 2003;52(1):145-8.
2002: Waller Simon C; Rees Lesley; Woolf Adrian S; Ellard Sian; Pearson Ewan R; Hattersley Andrew T; Bingham Coralie
Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2002;40(6):1325-30.
2002: Stride Amanda; Shepherd Maggie; Frayling Timothy M; Bulman Mike P; Ellard Sian; Hattersley Andrew T
Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.
Diabetes care 2002;25(12):2287-91.
2002: Thomas Heike; Badenberg Britta; Bulman Michael; Lemm Ira; Lausen Jörn; Kind Lucy; Roosen Simone; Ellard Sian; Hattersley Andrew T; Ryffel Gerhart U
Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations.
Biological chemistry 2002;383(11):1691-700.
2002: Dobson L; Hattersley A T; Tiley S; Elworthy S; Oades P J; Sheldon C D
Clinical improvement in cystic fibrosis with early insulin treatment.
Archives of disease in childhood 2002;87(5):430-1.
2002: Bulman M P; Harries L W; Hansen T; Shepherd M; Kelly W F; Hattersley A T; Ellard S
Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.
Diabetologia 2002;45(10):1463-7.
2002: Mitchell S M S; Vaxillaire M; Thomas H; Parrizas M; Benmezroua Y; Costa A; Hansen T; Owen K R; Tuomi T; Pirie F; Ryffel G U; Ferrer J; Froguel P; Hattersley A T; Frayling T M
Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.
Diabetologia 2002;45(9):1344-8.
2002: Owen K R; Shepherd M; Stride A; Ellard S; Hattersley A T
Heterogeneity in young adult onset diabetes: aetiology alters clinical characteristics.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(9):758-61.
2002: Fava Stephen; Hattersley Andrew T
The role of genetic susceptibility in diabetic nephropathy: evidence from family studies.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(9):1543-6.
2002: Stride Amanda; Lambert Paul; Burden A C Felix; Mansell Peter; Page Simon; Hattersley Andrew T
Necrobiosis lipodica is a clinical feature of maturity-onset diabetes of the young.
Diabetes care 2002;25(7):1249-50.
2002: Gloyn Anna L; Ellard Sian; Shepherd Maggie; Howell Rodney T; Parry Elizabeth M; Jefferson Andrew; Levy Elaine R; Hattersley Andrew T
Maturity-onset diabetes of the young caused by a balanced translocation where the 20q12 break point results in disruption upstream of the coding region of hepatocyte nuclear factor-4alpha (HNF4A) gene.
Diabetes 2002;51(7):2329-33.
2002: Frayling Timothy M; Hattersley Andrew T; McCarthy Anne; Holly Jeff; Mitchell Simon M S; Gloyn Anna L; Owen Katharine; Davies David; Smith George Davey; Ben-Shlomo Yoav
A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations.
Diabetes 2002;51(7):2313-6.
2002: Shore A C; Evans J C; Frayling T M; Clark P M; Lee B C; Horikawa Y; Hattersley A T; Tooke J E
Association of calpain-10 gene with microvascular function.
Diabetologia 2002;45(6):899-904.
2002: Mitchell Simon M S; Gloyn Anna L; Owen Katharine R; Hattersley Andrew T; Frayling Timothy M
The role of the HNF4alpha enhancer in type 2 diabetes.
Molecular genetics and metabolism 2002;76(2):148-51.
2002: Turner Jeremy J O; Leotlela Poloko D; Pannett Anna A J; Forbes Simon A; Bassett J H Duncan; Harding Brian; Christie Paul T; Bowen-Jones David; Ellard Sian; Hattersley Andrew; Jackson Charles E; Pope Richard; Quarrell Oliver W; Trembath Richard; Thakker Rajesh V
Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1.
The Journal of clinical endocrinology and metabolism 2002;87(6):2688-93.
2002: Haddad Lema; Evans Julie C; Gharani Neda; Robertson Carole; Rush Karen; Wiltshire Steven; Frayling Timothy M; Wilkin Terence J; Demaine Andrew; Millward Ann; Hattersley Andrew T; Conway Gerry; Cox Nancy J; Bell Graeme I; Franks Steve; McCarthy Mark I
Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(6):2606-10.
2002: Gloyn A L; Desai M; Clark A; Levy J C; Holman R R; Frayling T M; Hattersley A T; Ashcroft S J H
Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes.
Diabetologia 2002;45(4):580-3.
2002: Bingham Coralie; Ellard Sian; Cole Trevor R P; Jones Katrin E; Allen Lisa I S; Goodship Judith A; Goodship Timothy H J; Bakalinova-Pugh Daniela; Russell Gavin I; Woolf Adrian S; Nicholls Anthony J; Hattersley Andrew T
Solitary functioning kidney and diverse genital tract malformations associated with hepatocyte nuclear factor-1beta mutations.
Kidney international 2002;61(4):1243-51.
2002: Minton Jayne A L; Hattersley Andrew T; Owen Katharine; McCarthy Mark I; Walker Mark; Latif Farida; Barrett Timothy; Frayling Timothy M
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.
Diabetes 2002;51(4):1287-90.
2002: Stride A; Vaxillaire M; Tuomi T; Barbetti F; Njølstad P R; Hansen T; Costa A; Conget I; Pedersen O; Søvik O; Lorini R; Groop L; Froguel P; Hattersley A T
The genetic abnormality in the beta cell determines the response to an oral glucose load.
Diabetologia 2002;45(3):427-35.
2002: Owen Katharine; Ayres Susan; Corbett Sheila; Hattersley Andrew
Increased risk of diabetes in first-degree relatives of young-onset type 2 diabetic patients compared with relatives of those diagnosed later.
Diabetes care 2002;25(3):636-7.
2002: Gloyn A L; Ellard S; Shield J P; Temple I K; Mackay D J G; Polak M; Barrett T; Hattersley A T
Complete glucokinase deficiency is not a common cause of permanent neonatal diabetes.
Diabetologia 2002;45(2):290.
2002: Wiltshire Steven; Frayling Timothy M; Hattersley Andrew T; Hitman Graham A; Walker Mark; Levy Jonathan C; O'Rahilly Stephen; Groves Christopher J; Menzel Stephan; Cardon Lon R; McCarthy Mark I
Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
American journal of human genetics 2002;70(2):543-6.
2002: Lynn Stephen; Evans Julie C; White Christopher; Frayling Timothy M; Hattersley Andrew T; Turnbull Doug M; Horikawa Yukio; Cox Nancy J; Bell Graeme I; Walker Mark
Variation in the calpain-10 gene affects blood glucose levels in the British population.
Diabetes 2002;51(1):247-50.
2002: Stride Amanda; Hattersley Andrew T
Different genes, different diabetes: lessons from maturity-onset diabetes of the young.
Annals of medicine 2002;34(3):207-16.
2001: Fava S; Azzopardi J; Ellard S; Hattersley A T
ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease.
Diabetes care 2001;24(12):2115-20.
2001: Kolatsi-Joannou M; Bingham C; Ellard S; Bulman M P; Allen L I; Hattersley A T; Woolf A S
Hepatocyte nuclear factor-1beta: a new kindred with renal cysts and diabetes and gene expression in normal human development.
Journal of the American Society of Nephrology : JASN 2001;12(10):2175-80.
2001: Thomas H; Jaschkowitz K; Bulman M; Frayling T M; Mitchell S M; Roosen S; Lingott-Frieg A; Tack C J; Ellard S; Ryffel G U; Hattersley A T
A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.
Human molecular genetics 2001;10(19):2089-97.
2001: Owen K; Hattersley A T
Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization.
Best practice & research. Clinical endocrinology & metabolism 2001;15(3):309-23.
2001: Bingham C; Ellard S; Nicholls A J; Pennock C A; Allen J; James A J; Satchell S C; Salzmann M B; Hattersley A T
The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria.
Diabetes 2001;50(9):2047-52.
2001: Wiltshire S; Hattersley A T; Hitman G A; Walker M; Levy J C; Sampson M; O'Rahilly S; Frayling T M; Bell J I; Lathrop G M; Bennett A; Dhillon R; Fletcher C; Groves C J; Jones E; Prestwich P; Simecek N; Rao P V; Wishart M; Bottazzo G F; Foxon R; Howell S; Smedley D; Cardon L R; Menzel S; McCarthy M I
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.
American journal of human genetics 2001;69(3):553-69.
2001: Evans J C; Frayling T M; Cassell P G; Saker P J; Hitman G A; Walker M; Levy J C; O'Rahilly S; Rao P V; Bennett A J; Jones E C; Menzel S; Prestwich P; Simecek N; Wishart M; Dhillon R; Fletcher C; Millward A; Demaine A; Wilkin T; Horikawa Y; Cox N J; Bell G I; Ellard S; McCarthy M I; Hattersley A T
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.
American journal of human genetics 2001;69(3):544-52.
2001: Kousta E; Ellard S; Allen L I; Saker P J; Huxtable S J; Hattersley A T; McCarthy M I
Glucokinase mutations in a phenotypically selected multiethnic group of women with a history of gestational diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(8):683-4.
2001: Lee B C; Shore A C; Humphreys J M; Lowe G D; Rumley A; Clark P M; Hattersley A T; Tooke J E
Skin microvascular vasodilatory capacity in offspring of two parents with Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(7):541-5.
2001: Spyer G; Hattersley A T; Sykes J E; Sturley R H; MacLeod K M
Influence of maternal and fetal glucokinase mutations in gestational diabetes.
American journal of obstetrics and gynecology 2001;185(1):240-1.
2001: Coward R J; Risdon R A; Bingham C; Hattersley A T; Woolf A S
Kidney disease in hypomelanosis of Ito.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(6):1267-9.
2001: Shepherd M; Ellis I; Ahmad A M; Todd P J; Bowen-Jones D; Mannion G; Ellard S; Sparkes A C; Hattersley A T
Predictive genetic testing in maturity-onset diabetes of the young (MODY).
Diabetic medicine : a journal of the British Diabetic Association 2001;18(5):417-21.
2001: Fava S; Azzopardi J; Watkins P J; Hattersley A T
Adult height and proteinuria in type 2 diabetes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(3):525-8.
2001: Frayling T M; Evans J C; Bulman M P; Pearson E; Allen L; Owen K; Bingham C; Hannemann M; Shepherd M; Ellard S; Hattersley A T
beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
Diabetes 2001;50 Suppl 1():S94-100.
2001: Pearson E R; Velho G; Clark P; Stride A; Shepherd M; Frayling T M; Bulman M P; Ellard S; Froguel P; Hattersley A T
beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.
Diabetes 2001;50 Suppl 1():S101-7.
2001: Bingham C; Bulman M P; Ellard S; Allen L I; Lipkin G W; Hoff W G; Woolf A S; Rizzoni G; Novelli G; Nicholls A J; Hattersley A T
Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease.
American journal of human genetics 2001;68(1):219-24.
2001: Frayling T M; Hattersley A T
The role of genetic susceptibility in the association of low birth weight with type 2 diabetes.
British medical bulletin 2001;60():89-101.
2000: Cassell P G; Saker P J; Huxtable S J; Kousta E; Jackson A E; Hattersley A T; Frayling T M; Walker M; Kopelman P G; Ramachandran A; Snehelatha C; Hitman G A; McCarthy M I
Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin.
Diabetologia 2000;43(12):1558-64.
2000: Spyer G; Hattersley A T; MacDonald I A; Amiel S; MacLeod K M
Hypoglycaemic counter-regulation at normal blood glucose concentrations in patients with well controlled type-2 diabetes.
Lancet 2000;356(9246):1970-4.
2000: Ellard S; Bulman M P; Frayling T M; Shepherd M; Hattersley A T
Proposed mechanism for a novel insertion/deletion frameshift mutation (I414G415ATCG-->CCA) in the hepatocyte nuclear factor 1 alpha (HNF-1 alpha) gene which causes maturity-onset diabetes of the young (MODY).
Human mutation 2000;16(3):273.
2000: Pearson E R; Liddell W G; Shepherd M; Corrall R J; Hattersley A T
Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(7):543-5.
2000: Wild W; Pogge von Strandmann E; Nastos A; Senkel S; Lingott-Frieg A; Bulman M; Bingham C; Ellard S; Hattersley A T; Ryffel G U
The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4695-700.
2000: Fava S; Azzopardi J; Hattersley A T; Watkins P J
Increased prevalence of proteinuria in diabetic sibs of proteinuric type 2 diabetic subjects.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2000;35(4):708-12.
2000: Shepherd M; Hattersley A T; Sparkes A C
Predictive genetic testing in diabetes: a case study of multiple perspectives.
Qualitative health research 2000;10(2):242-59.
2000: Lynn S; Hattersley A T; McCarthy M I; Frayling T M; Turnbull D M; Walker M
Intermediate expansions of a X25/frataxin gene GAA repeat and type II diabetes: assessment using parent-offspring trios.
Diabetologia 2000;43(3):384-5.
2000: Bingham C; Ellard S; Allen L; Bulman M; Shepherd M; Frayling T; Berry P J; Clark P M; Lindner T; Bell G I; Ryffel G U; Nicholls A J; Hattersley A T
Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.
Kidney international 2000;57(3):898-907.
2000: Ellard S; Beards F; Allen L I; Shepherd M; Ballantyne E; Harvey R; Hattersley A T
A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
Diabetologia 2000;43(2):250-3.
2000: Frayling T M; McCarthy M I; Walker M; Levy J C; O'Rahilly S; Hitman G A; Rao P V; Bennett A J; Jones E C; Menzel S; Ellard S; Hattersley A T
No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
The Journal of clinical endocrinology and metabolism 2000;85(2):853-7.
2000: Huxtable S J; Saker P J; Haddad L; Walker M; Frayling T M; Levy J C; Hitman G A; O'Rahilly S; Hattersley A T; McCarthy M I
Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Diabetes 2000;49(1):126-30.
2000: Lausen J; Thomas H; Lemm I; Bulman M; Borgschulze M; Lingott A; Hattersley A T; Ryffel G U
Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.
Nucleic acids research 2000;28(2):430-7.
2000: Hattersley A T
Diagnosis of maturity-onset diabetes of the young in the pediatric diabetes clinic.
Journal of pediatric endocrinology & metabolism : JPEM 2000;13 Suppl 6():1411-7.
1999: Frayling T M; Walker M; McCarthy M I; Evans J C; Allen L I; Lynn S; Ayres S; Millauer B; Turner C; Turner R C; Sampson M J; Hitman G A; Ellard S; Hattersley A T
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
Diabetes 1999;48(12):2475-9.
1999: Macfarlane W M; Frayling T M; Ellard S; Evans J C; Allen L I; Bulman M P; Ayres S; Shepherd M; Clark P; Millward A; Demaine A; Wilkin T; Docherty K; Hattersley A T
Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.
The Journal of clinical investigation 1999;104(9):R33-9.
1999: Hattersley A
Can molecular genetics help in the clinic?
Diabetic medicine : a journal of the British Diabetic Association 1999;16(9):788-91.
1999: Lee B C; Appleton M; Shore A C; Tooke J E; Hattersley A T
Impaired maximum microvascular hyperaemia in patients with MODY 3 (hepatocyte nuclear factor-1alpha gene mutations).
Diabetic medicine : a journal of the British Diabetic Association 1999;16(9):731-5.
1999: Miedzybrodzka Z; Hattersley A T; Ellard S; Pearson D; de Silva D; Harvey R; Haites N
Non-penetrance in a MODY 3 family with a mutation in the hepatic nuclear factor 1alpha gene: implications for predictive testing.
European journal of human genetics : EJHG 1999;7(6):729-32.
1999: Heward J M; Allahabadia A; Armitage M; Hattersley A; Dodson P M; Macleod K; Carr-Smith J; Daykin J; Daly A; Sheppard M C; Holder R L; Barnett A H; Franklyn J A; Gough S C
The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.
The Journal of clinical endocrinology and metabolism 1999;84(7):2398-401.
1999: Smith P R; Bain S C; Good P A; Hattersley A T; Barnett A H; Gibson J M; Dodson P M
Pigmentary retinal dystrophy and the syndrome of maternally inherited diabetes and deafness caused by the mitochondrial DNA 3243 tRNA(Leu) A to G mutation.
Ophthalmology 1999;106(6):1101-8.
1999: Hattersley A T; Tooke J E
The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease.
Lancet 1999;353(9166):1789-92.
1999: Lemm I; Lingott A; Pogge v Strandmann E; Zoidl C; Bulman M P; Hattersley A T; Schulz W A; Ebert T; Ryffel G U
Loss of HNF1alpha function in human renal cell carcinoma: frequent mutations in the VHL gene but not the HNF1alpha gene.
Molecular carcinogenesis 1999;24(4):305-14.
1999: Ellard S; Bulman M P; Frayling T M; Allen L I; Dronsfield M J; Tack C J; Hattersley A T
Allelic drop-out in exon 2 of the hepatocyte nuclear factor-1alpha gene hinders the identification of mutations in three families with maturity-onset diabetes of the young.
Diabetes 1999;48(4):921-3.
1998: Tack C J; Hattersley A T
[A Dutch family with an autosomal dominant form of diabetes mellitus as a result of a mutation in the HNF1 alpha-gene (MODY3)]
Nederlands tijdschrift voor geneeskunde 1998;142(41):2252-6.
1998: Hattersley A T; Beards F; Ballantyne E; Appleton M; Harvey R; Ellard S
Mutations in the glucokinase gene of the fetus result in reduced birth weight.
Nature genetics 1998;19(3):268-70.
1998: Beards F; Frayling T; Bulman M; Horikawa Y; Allen L; Appleton M; Bell G I; Ellard S; Hattersley A T
Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.
Diabetes 1998;47(7):1152-4.
1998: Matyka K A; Beards F; Appleton M; Ellard S; Hattersley A; Dunger D B
Genetic testing for maturity onset diabetes of the young in childhood hyperglycaemia.
Archives of disease in childhood 1998;78(6):552-4.
1998: Frayling T; Ellard S; Grove J; Walker M; Hattersley A T
C282Y mutation in HFE (haemochromatosis) gene and type 2 diabetes.
Lancet 1998;351(9120):1933-4.
1997: Smith P R; Dronsfield M J; Mijovic C H; Hattersley A T; Yeung V T; Cockram C; Chan J C; Barnett A H; Bain S C
The mitochondrial tRNA[Leu(UUR)] A to G 3243 mutation is associated with insulin-dependent and non-insulin-dependent diabetes in a Chinese population.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(12):1026-31.
1997: Frayling T M; Bulman M P; Appleton M; Hattersley A T; Ellard S
A rapid screening method for hepatocyte nuclear factor 1 alpha frameshift mutations; prevalence in maturity-onset diabetes of the young and late-onset non-insulin dependent diabetes.
Human genetics 1997;101(3):351-4.
1997: Bulman M P; Dronsfield M J; Frayling T; Appleton M; Bain S C; Ellard S; Hattersley A T
A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young.
Diabetologia 1997;40(7):859-62.
1997: Frayling T M; Bulamn M P; Ellard S; Appleton M; Dronsfield M J; Mackie A D; Baird J D; Kaisaki P J; Yamagata K; Bell G I; Bain S C; Hattersley A T
Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.
Diabetes 1997;46(4):720-5.
1997: Hattersley A T
Genes versus environment in insulin-dependent diabetes: the phoney war.
Lancet 1997;349(9046):147-8.
1997: Saker P J; Hattersley A T; Barrow B; Hammersley M S; Horton V; Gillmer M D; Turner R C
UKPDS 21: low prevalence of the mitochondrial transfer RNA gene (tRNA(Leu(UUR))) mutation at position 3243bp in UK Caucasian type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(1):42-5.
1996: Yamagata K; Oda N; Kaisaki P J; Menzel S; Furuta H; Vaxillaire M; Southam L; Cox R D; Lathrop G M; Boriraj V V; Chen X; Cox N J; Oda Y; Yano H; Le Beau M M; Yamada S; Nishigori H; Takeda J; Fajans S S; Hattersley A T; Iwasaki N; Hansen T; Pedersen O; Polonsky K S; Bell G I
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Nature 1996;384(6608):455-8.
1996: Saker P J; Hattersley A T; Barrow B; Hammersley M S; McLellan J A; Lo Y M; Olds R J; Gillmer M D; Holman R R; Turner R C
High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population.
Diabetologia 1996;39(11):1325-8.
1996: Byrne M M; Sturis J; Menzel S; Yamagata K; Fajans S S; Dronsfield M J; Bain S C; Hattersley A T; Velho G; Froguel P; Bell G I; Polonsky K S
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
Diabetes 1996;45(11):1503-10.
1995: Zhang Y; Warren-Perry M; Saker P J; Hattersley A T; Mackie A D; Baird J D; Greenwood R H; Stoffel M; Bell G I; Turner R C
Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase.
Diabetologia 1995;38(9):1055-60.
1995: McLellan J A; Barrow B A; Levy J C; Hammersley M S; Hattersley A T; Gillmer M D; Turner R C
Prevalence of diabetes mellitus and impaired glucose tolerance in parents of women with gestational diabetes.
Diabetologia 1995;38(6):693-8.
1995: Page R C; Hattersley A T; Levy J C; Barrow B; Patel P; Lo D; Wainscoat J S; Permutt M A; Bell G I; Turner R C
Clinical characteristics of subjects with a missense mutation in glucokinase.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(3):209-17.
1995: Turner R C; Hattersley A T; Shaw J T; Levy J C
Type II diabetes: clinical aspects of molecular biological studies.
Diabetes 1995;44(1):1-10.
1994: Cook J T; Shields D C; Page R C; Levy J C; Hattersley A T; Shaw J A; Neil H A; Wainscoat J S; Turner R C
Segregation analysis of NIDDM in Caucasian families.
Diabetologia 1994;37(12):1231-40.
1994: Zhang Y; Cook J T; Hattersley A T; Firth R; Saker P J; Warren-Perry M; Stoffel M; Turner R C
Non-linkage of the glucagon-like peptide 1 receptor gene with maturity onset diabetes of the young.
Diabetologia 1994;37(7):721-4.
1993: Cook J T; Page R C; O'Rahilly S; Levy J; Holman R; Barrow B; Hattersley A T; Shaw A G; Wainscoat J S; Turner R C
Availability of type II diabetic families for detection of diabetes susceptibility genes.
Diabetes 1993;42(10):1536-43.
1993: Hattersley A T; Saker P J; Cook J T; Stratton I M; Patel P; Permutt M A; Turner R C; Wainscoat J S
Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(8):694-8.
1993: Hattersley A T; Turner R C
Mutations of the glucokinase gene and type 2 diabetes.
The Quarterly journal of medicine 1993;86(4):227-32.
1993: Hattersley A T; Saker P J; Patel P; Lo Y M; Page R; O'Rahilly S; Turner R C; Permutt M A; Wainscoat J S
Linkage of maturity-onset diabetes of the young to the glucokinase gene--evidence of genetic heterogeneity.
Biochemical Society transactions 1993;21(1):24S.
1993: Cook J T; Levy J C; Page R C; Shaw J A; Hattersley A T; Turner R C
Association of low birth weight with beta cell function in the adult first degree relatives of non-insulin dependent diabetic subjects.
BMJ (Clinical research ed.) 1993;306(6873):302-6.
1993: Cook J T; Hattersley A T; Levy J C; Patel P; Wainscoat J S; Hockaday T D; Turner R C
Distribution of type II diabetes in nuclear families.
Diabetes 1993;42(1):106-12.
1992: Cook J T; Hattersley A T; Christopher P; Bown E; Barrow B; Patel P; Shaw J A; Cookson W O; Permutt M A; Turner R C
Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.
Diabetes 1992;41(11):1496-500.
1992: Stoffel M; Patel P; Lo Y M; Hattersley A T; Lucassen A M; Page R; Bell J I; Bell G I; Turner R C; Wainscoat J S
Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.
Nature genetics 1992;2(2):153-6.
1991: Turner R C; Clark A; Levy J; Hattersley A T; Cook J C
[Insulin secretion in non-insulin-dependent diabetes]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1991;():141-51.

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