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Nobutaka Hattori

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Hideaki Matsui; Shinji Saiki; Yoshiyuki Sakaki; Fumiaki Sato; Shigeto Sato; Manabu Funayama; Nobutaka Hattori; Hidefumi Ito; Masato Koike; Shunichi Takeda; Yoshihito Taniguchi; Yosuke Taruno; Atsushi Toyoda; Yasuo Uchiyama; Norihito Uemura; Ryosuke Takahashi
ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons.
Yumiko Mitome-Mishima; Nobukazu Miyamoto; Hidenori Oishi; Ryota Tanaka; Hajime Arai; Nobutaka Hattori; Takao Urabe
Differences in phosphodiesterase 3A and 3B expression after ischemic insult.
Taku Hatano; Nobutaka Hattori; Shin-Ichiro Kubo; Yuko Niijima-Ishii; Yukihiro Sugita
Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages.

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2013: Hideaki Matsui; Shinji Saiki; Yoshiyuki Sakaki; Fumiaki Sato; Shigeto Sato; Manabu Funayama; Nobutaka Hattori; Hidefumi Ito; Masato Koike; Shunichi Takeda; Yoshihito Taniguchi; Yosuke Taruno; Atsushi Toyoda; Yasuo Uchiyama; Norihito Uemura; Ryosuke Takahashi
ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons.
FEBS letters 2013;587(9):1316-25.
2013: Yumiko Mitome-Mishima; Nobukazu Miyamoto; Hidenori Oishi; Ryota Tanaka; Hajime Arai; Nobutaka Hattori; Takao Urabe
Differences in phosphodiesterase 3A and 3B expression after ischemic insult.
Neuroscience research 2013;75(4):340-8.
2013: Taku Hatano; Nobutaka Hattori; Shin-Ichiro Kubo; Yuko Niijima-Ishii; Yukihiro Sugita
Levodopa-responsive Parkinsonism following bilateral putaminal hemorrhages.
Parkinsonism & related disorders 2013;19(4):477-9.
2013: Hirotomo Homma; Tatsu Kobayakawa; Asako Yoritaka; Nobutaka Hattori; Katsuhisa Ikeda
Clinical application of a card-type odor identification test to olfactory assessment in Parkinson's disease.
Auris, nasus, larynx 2013;40(2):173-6.
2013: Nobukazu Miyamoto; Yoshiaki Shimada; Ryota Tanaka; Yasutaka Tanaka; Yuji Ueno; Nobutaka Hattori; Miyako Kawamura; Takao Urabe
Demographic, clinical, and radiologic predictors of neurologic deterioration in patients with acute ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2013;22(3):205-10.
2013: Ayami Okuzumi; Yoshiaki Shimada; Ryota Tanaka; Yasutaka Tanaka; Yuji Ueno; Nobutaka Hattori; Nobukazu Miyamoto; Kazuo Yamashiro; Takao Urabe
Impact of low-density lipoprotein to high-density lipoprotein ratio on aortic arch atherosclerosis in unexplained stroke.
Journal of the neurological sciences 2013;326(1-2):83-8.
2013: Saori Miyakawa; Yoshikuni Mizuno; Sayaka Funabe; Nobutaka Hattori; Masaaki Ichinoe; Tetuo Mikami; Hideo Mori; Shigeo Murayama; Kazutoshi Nishiyama; Mieko Ogino; Makoto Saegusa; Yasushi Shimo; Akiko Uchino; Hideki Mochizuki
Lewy body pathology in a patient with a homozygous parkin deletion.
Movement disorders : official journal of the Movement Disorder Society 2013;28(3):388-91.
2013: Sayaka Funabe; Hiroyuki Hatsuta; Nobutaka Hattori; Shinji Ito; Kazutomi Kanemaru; Hideki Mochizuki; Yuko Saito; Motoji Sawabe; Mikiko Sugiyama; Masaki Takao; Tomio Arai; Shigeo Murayama
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.
Neuropathology : official journal of the Japanese Society of Neuropathology 2013;33(1):47-58.
2013: Yoshiaki Shimada; Ryota Tanaka; Yasutaka Tanaka; Yuji Ueno; Nobutaka Hattori; Nobukazu Miyamoto; Ayami Okuzumi; Kazuo Yamashiro; Takao Urabe
Aging, aortic arch calcification, and multiple brain infarcts are associated with aortogenic brain embolism.
Cerebrovascular diseases (Basel, Switzerland) 2013;35(3):282-90.
2013: Atsuhito Fuse; Nobutaka Hattori; Kazuyuki Noda; Yutaka Oji; Tsuyoshi Furuya; Kazuo Yamashiro; Yasuyuki Okuma
Reversible focal cerebral cortical lesions in a patient with heat stroke.
Internal medicine (Tokyo, Japan) 2013;52(3):377-80.
2013: Mariko Yoshida; Issa Fukunaga; Nobutaka Hattori; Masaaki Hori; Koji Kamagata; Yoshitaka Masutani; Atsushi Nakanishi; Keigo Shimoji; Michimasa Suzuki; Kazumasa Yokoyama; Shigeki Aoki
Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience.
Japanese journal of radiology 2013;31(1):50-5.
2013: Yasutaka Tanaka; Yuji Ueno; Nobutaka Hattori; Nobukazu Miyamoto; Yoshiaki Shimada; Ryota Tanaka; Takao Urabe
Patent foramen ovale and atrial septal aneurysm can cause ischemic stroke in patients with antiphospholipid syndrome.
Journal of neurology 2013;260(1):189-96.
2013: Kotaro Ogaki; Ryogen Sasaki; Keiichi Shioya; Masashi Takanashi; Hiroyuki Tomiyama; Tetsuro Tsukamoto; Masayuki Yokochi; Hiroyo Yoshino; H Imai; Kei-Ichi Ishikawa; Masahiko Kishi; Tomonori Kobayashi; Yasumasa Kokubo; S Kuzuhara; Yuanzhe Li; Yumiko Motoi; Takashi Nonaka; Manabu Funayama; Masato Hasegawa; Nobutaka Hattori
Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS.
Parkinsonism & related disorders 2013;19(1):15-20.
2012: Kazuo Yamashiro; Nobutaka Hattori; Kenya Nishioka; Yasuyuki Okuma; Hideki Shimura; Ryota Tanaka; Yuji Ueno; Takao Urabe
Cerebral infarcts associated with adenomyosis among middle-aged women.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(8):910.e1-5.
2012: Yoshiaki Shimada; Nobutaka Hattori; Nobukazu Miyamoto; Yasutaka Tanaka; Yuji Ueno; Asako Yoritaka; Urabe Takao
Cerebral infarction in a young man using high-dose anabolic steroids.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(8):906.e9-11.
2012: Kazuo Yamashiro; Yoshiaki Shimada; Takao Urabe; Tsuyoshi Furuya; Nobutaka Hattori; Akio Mori; Kazuyuki Noda; Yasuyuki Okuma
Gradient echo T2*-weighted magnetic resonance imaging revealing cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(8):904.e7-9.
2012: Kotaro Ogaki; Gen Sobue; Asako Tamura; Akira Taniguchi; Hiroyuki Tomiyama; Hazuki Watanabe; Seiji Yato; Hideo Yoshino; Naoki Atsuta; Koji Fujita; Manabu Funayama; Nobutaka Hattori; Yuishin Izumi; Ryuji Kaji; Yuanzhe Li; Yutaka Naito; Ryoichi Nakamura
Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosis.
Neurobiology of aging 2012;33(10):2527.e11-6.
2012: Kazuo Yamashiro; Takao Urabe; Tsuyoshi Furuya; Nobutaka Hattori; Kazuyuki Noda; Yasuyuki Okuma
Cerebral infarction developing in a patient without cancer with a markedly elevated level of mucinous tumor marker.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(7):619.e1-2.
2012: Maya Ando; Manabu Funayama; Takashi Hashimoto; Taku Hatano; Nobutaka Ishizu; Kenichi Kashihara; Yasumasa Kokubo; Shigeki Kuzuhara; Yuanzhe Li; Yoshitake Murakami; Naoki Nakano; Katsuhiko Noguchi; Kotaro Ogaki; Ryogen Sasaki; Hiroyuki Tomiyama; Chizuko Toyoda; Chikara Yamashita; Hiroyo Yoshino; Nobutaka Hattori
VPS35 mutation in Japanese patients with typical Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2012;27(11):1413-7.
2012: Jiro Fukae; Nobuaki Akao; Makiko Kado; Tadaaki Kawanabe; Masako Tokoro; Kazumasa Yokoyama; Nobutaka Hattori
Longitudinal myelitis caused by visceral larva migrans associated with Toxocara cati infection: case report.
Clinical neurology and neurosurgery 2012;114(7):1091-4.
2012: Hideki Shimura; Yoshikuni Mizuno; Nobutaka Hattori
Parkin and Parkinson disease.
Clinical chemistry 2012;58(8):1260-1.
2012: Sachiko Ujiie; Saburo Yagishita; Kazuko Hasegawa; Taku Hatano; Satoshi Imai; Hisayuki Kowa; Shin-Ichiro Kubo; Fumihiko Sakai; Shigeto Sato; Toshiki Uchihara; Nobutaka Hattori
LRRK2 I2020T mutation is associated with tau pathology.
Parkinsonism & related disorders 2012;18(7):819-23.
2012: Ryota Tanaka; Nobutaka Hattori; Hideki Oizumi; Yoshiaki Shimada; Hideki Shimura; Shigeki Tanaka
Predominant vasogenic edema in a patient with fatal cerebral air embolism.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(6):509-11.
2012: Yoshikuni Mizuno; Werner Poewe; Olivier Rascol; Akiko Sarashina; Anthony H V Schapira; Mitsutoshi Yamamoto; Paolo Barone; Kazuko Hasegawa; Nobutaka Hattori; Robert A Hauser; Tatsuro Kagimura; Sadako Kuno
Efficacy and safety of extended- versus immediate-release pramipexole in Japanese patients with advanced and (L)-dopa-undertreated Parkinson disease: a double-blind, randomized trial.
Clinical neuropharmacology 2012;35(4):174-81.
2012: Nobukazu Miyamoto; Ryota Tanaka; Yasutaka Tanaka; Yuji Ueno; Nobutaka Hattori; Takao Urabe
Benefits of prestroke use of angiotensin type 1 receptor blockers on ischemic stroke severity.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(5):363-8.
2012: Hideki Shimura; Ryota Tanaka; Shigeki Tanaka; Takao Urabe; Nobutaka Hattori
Art and Parkinson's disease: a dramatic change in an artist's style as an initial symptom.
Journal of neurology 2012;259(5):879-81.
2012: Manabu Funayama; Hiromichi Kusaka; Yuanzhe Li; Hiroyuki Tomiyama; Hiroyo Yoshino; Nobutaka Hattori
Pseudo-heterozygous rearrangement mutation of parkin.
Movement disorders : official journal of the Movement Disorder Society 2012;27(4):552-5.
2012: Kohei Shimada; Atsuko Shinohara; Takashi Ueno; Momoko Chiba; Koichi Ishiguro; Masako Itaya; Taiki Kambe; Miyuki Kunichika; Shin-Ei Matsumoto; Yoshikuni Mizuno; Hideo Mori; Yumiko Motoi; Nobutaka Hattori
Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: implications of autophagy promotion.
Neurobiology of disease 2012;46(1):101-8.
2012: Shinji Saiki; Shigeto Sato; Nobutaka Hattori
Molecular pathogenesis of Parkinson's disease: update.
Journal of neurology, neurosurgery, and psychiatry 2012;83(4):430-6.
2012: Ryota Tanaka; Nobutaka Hattori; Tadaaki Kawanabe; Nobukazu Miyamoto; Hideki Shimura; Yasutaka Tanaka; Yuji Ueno; Takao Urabe; Yoshiya Yamauchi; Shigeki Tanaka
Economy class stroke syndrome after a long drive.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2012;21(2):155-7.
2012: Kahori Shiba-Fukushima; Shigeharu Yoshida; Yuzuru Imai; Yasushi Ishihama; Tomoko Kanao; Shigeto Sato; Nobutaka Hattori
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.
Scientific reports 2012;2():1002.
2012: Nobutaka Hattori; Tomoyoshi Kondo; Miho Murata; Kenichi Fujimoto; Mark Stacy
Patient perspectives on Parkinson's disease therapy in Japan and the United States: results of two patient surveys.
Patient related outcome measures 2012;3():31-8.
2012: Yoichi Imaizumi; Daisuke Ito; Tetsuro Kobayashi; Masato Koike; Arifumi Kosakai; Naoko Kuzumaki; Yoshikuni Mizuno; Noboru Mizushima; Hideki Mochizuki; Atsushi Nakanishi; Tomoko Nihira; Manabu Ohyama; Yohei Okada; Wado Akamatsu; Masayuki Amagai; Manabu Funayama; Nobutaka Hattori; Hideki Hayakawa; Kozo Hayashi; Akiyoshi Hirayama; Takako Hishiki; Shigeto Sato; Masanobu Shouji; Tomoyoshi Soga; Makoto Suematsu; Norihiro Suzuki; Masashi Takanashi; Yasuo Uchiyama; Takuya Yagi; Hideyuki Okano
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Molecular brain 2012;5():35.
2012: Y Tomizawa; K Yokoyama; J Matsuoka; Shinji Saiki; T Takahashi; Nobutaka Hattori
Blood-brain barrier disruption is more severe in neuromyelitis optica than in multiple sclerosis and correlates with clinical disability.
The Journal of international medical research 2012;40(4):1483-91.
2012: Nobuto Shibata; Hiroyuki Tomiyama; Katrin Tomson; Nobutaka Hattori; Miwa Komatsu; Bolati Kuerban; Yumiko Motoi; Tohru Ohnuma; Heii Arai
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
Dementia and geriatric cognitive disorders 2012;33(4):250-4.
2012: Masashi Takanashi; Nobutaka Hattori
[Neurodegenerative diseases].
Nihon rinsho. Japanese journal of clinical medicine 2012;70(1):94-8.
2012: Tomoko Kanao; Tomoyo Sawada; Ryosuke Takahashi; Shireen-Anne Davies; Kazuko Hasegawa; Nobutaka Hattori; Hiroshi Ichinose; Yuzuru Imai
The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila.
PloS one 2012;7(2):e30958.
2012: Naoki Ichikawa-Tomikawa; Yuji Kamikubo; Shinichi Kohsaka; Junko Ogawa; Takashi Sakurai; Zhuo Xu; Yoshihiko Yamada; Hideki Chiba; Vanessa Douet; Nobutaka Hattori; Eri Arikawa-Hirasawa
Laminin α1 is essential for mouse cerebellar development.
Matrix biology : journal of the International Society for Matrix Biology 2012;31(1):17-28.
2011: Nobutaka Hattori; Mika Imaizumi; Shinji Saiki; Shigeto Sato; Hiroto Eguchi; Shinya Nagamatsu
[The pathomechanisms of young-onset Parkinson's disease (PD), approach to the causes of PD form the mechanisms of insulin secretion system].
Rinshō shinkeigaku = Clinical neurology 2011;51(11):986-7.
2011: Ryota Tanaka; Nobutaka Hattori; Kenya Nishioka; Kumi Sasaki-Ikesawa; Hideki Shimura; Shigeki Tanaka
Methotrexate leukoencephalopathy mimics acute progressive stroke.
Journal of neurology 2011;258(11):2083-5.
2011: Sumihiro Kawajiri; Shinji Saiki; Shigeto Sato; Nobutaka Hattori
Genetic mutations and functions of PINK1.
Trends in pharmacological sciences 2011;32(10):573-80.
2011: Naomi Seki; Yuji K Takahashi; Hiroyuki Tomiyama; Peter St George-Hyslop; Jun Goto; Nobutaka Hattori; Anthony E Lang; Connie Marras; Yoshikuni Mizuno; Shigeo Murayama; Ekaterina Rogaeva; Shoji Tsuji
Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease.
Journal of human genetics 2011;56(9):671-5.
2011: Yukiko Usami; Hiroyoshi Ariga; Hiroto Eguchi; Yoichiro Fujioka; Manabu Funayama; Taku Hatano; Satoshi Imai; Shin-Ichiro Kubo; Yusuke Ohba; Shinji Saiki; Fumiaki Sato; Shigeto Sato; Jie Shen; Kaori Shiba; Nobutaka Hattori
DJ-1 associates with synaptic membranes.
Neurobiology of disease 2011;43(3):651-62.
2011: Chie Usui; Nagafumi Doi; Kotaro Hatta; Nobutaka Hattori; Rie Kamigaichi; Shinichiro Kubo; Hiroyuki Nakamura; Atsushi Nakanishi; Heii Arai
Improvements in both psychosis and motor signs in Parkinson's disease, and changes in regional cerebral blood flow after electroconvulsive therapy.
Progress in neuro-psychopharmacology & biological psychiatry 2011;35(7):1704-8.
2011: Hiroyuki Tomiyama; Hiroyo Yoshino; Nobutaka Hattori
Analysis of PLA2G6 in patients with frontotemporal type of dementia.
Parkinsonism & related disorders 2011;17(6):493-4.
2011: Taiki Kambe; Yumiko Motoi; Ran Inoue; Nobuhiko Kojima; Norihiro Tada; Tetsuya Kimura; Naruhiko Sahara; Shunji Yamashita; Tatsuya Mizoroki; Akihiko Takashima; Kohei Shimada; Koichi Ishiguro; Hiroshi Mizuma; Hirotaka Onoe; Yoshikuni Mizuno; Nobutaka Hattori
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.
Neurobiology of disease 2011;42(3):404-14.
2011: Hiroyuki Tomiyama; Hiroyo Yoshino; Kotaro Ogaki; Lin Li; Chikara Yamashita; Yuanzhe Li; Manabu Funayama; Ryogen Sasaki; Yasumasa Kokubo; Shigeki Kuzuhara; Nobutaka Hattori
PLA2G6 variant in Parkinson's disease.
Journal of human genetics 2011;56(5):401-3.
2011: Koji Kamagata; Yumiko Motoi; Masaaki Hori; Michimasa Suzuki; Atsushi Nakanishi; Keigo Shimoji; Shinsuke Kyougoku; Ryohei Kuwatsuru; Keisuke Sasai; Osamu Abe; Yoshikuni Mizuno; Shigeki Aoki; Nobutaka Hattori
Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI.
Journal of magnetic resonance imaging : JMRI 2011;33(4):803-7.
2011: Genko Oyama; Yasushi Shimo; Shihoko Natori; Madoka Nakajima; Hisato Ishii; Hajime Arai; Nobutaka Hattori
Acute effects of bilateral subthalamic stimulation on decision-making in Parkinson's disease.
Parkinsonism & related disorders 2011;17(3):189-93.
2011: Kotaro Ogaki; Yumiko Motoi; Yuanzhe Li; Hiroyuki Tomiyama; Natsue Shimizu; Masashi Takanashi; Atsushi Nakanishi; Kazumasa Yokoyama; Nobutaka Hattori
Visual grasping in frontotemporal dementia and parkinsonism linked to chromosome 17 (microtubule-associated with protein tau): a comparison of N-Isopropyl-p-[(123)I]-iodoamphetamine brain perfusion single photon emission computed tomography analysis with progressive supranuclear palsy.
Movement disorders : official journal of the Movement Disorder Society 2011;26(3):561-3.
2011: Chieri Hayashi; Manabu Funayama; Yuanzhe Li; Kazusaku Kamiya; Atsushi Kawano; Mamoru Suzuki; Nobutaka Hattori; Katsuhisa Ikeda
Prevalence of GJB2 causing recessive profound non-syndromic deafness in Japanese children.
International journal of pediatric otorhinolaryngology 2011;75(2):211-4.
2011: Shinji Saiki; Yukiko Sasazawa; Yoko Imamichi; Sumihiro Kawajiri; Takahiro Fujimaki; Isei Tanida; Hiroki Kobayashi; Fumiaki Sato; Shigeto Sato; Ken-Ichi Ishikawa; Masaya Imoto; Nobutaka Hattori
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.
Autophagy 2011;7(2):176-87.
2011: Taku Hatano; Ayako Kono; Shin-Ichiro Kubo; Toshiki Nakahara; Yoshiaki Shimada; Yukitoshi Takahashi; Kazumasa Yokoyama; Asako Yoritaka; Nobutaka Hattori
Atypical Miller Fisher syndrome associated with glutamate receptor antibodies.
BMJ case reports 2011;2011():.
2011: Tadaaki Kawanabe; Yohei Sakaguchi; Hideki Shimura; Ryota Tanaka; Osamu Akiyama; Nobutaka Hattori; Masanori Ito; Yukimasa Yasumoto; Shigeki Tanaka
Posterior reversible encephalopathy syndrome complicating intracranial hemorrhage after phenylpropanolamine exposure.
Neurologia medico-chirurgica 2011;51(8):582-5.
2011: Shigeto Sato; Nobutaka Hattori
Genetic mutations and mitochondrial toxins shed new light on the pathogenesis of Parkinson's disease.
Parkinson's disease 2011;2011():979231.
2011: Kazuyuki Noda; Jiro Fukae; Kenji Fujishima; Kentaro Mori; Takao Urabe; Nobutaka Hattori; Yasuyuki Okuma
Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage, reversible posterior leukoencephalopathy, and cerebral infarction.
Internal medicine (Tokyo, Japan) 2011;50(11):1227-33.
2011: Asako Yoritaka; Yumi Shimo; Yasushi Shimo; Yuichi Inoue; Hiroyo Yoshino; Nobutaka Hattori
Nonmotor Symptoms in Patients with PARK2 Mutations.
Parkinson's disease 2011;2011():473640.
2011: Hideki Oizumi; Ryota Tanaka; Hideki Shimura; Kumi Sasaki; Hiroyuki Koike; Nobutaka Hattori; Shigeki Tanaka
A case of cerebral embolism with metastatic chondrosarcoma in the left atrium.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2011;20(1):79-81.
2010: Y Tanaka; Ryota Tanaka; Meizi Liu; Nobutaka Hattori; Takao Urabe
Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia.
Neuroscience 2010;171(4):1367-76.
2010: Takeshi Sekine; Hajime Kagaya; Manabu Funayama; Yuanzhe Li; Hiroyo Yoshino; Hiroyuki Tomiyama; Nobutaka Hattori
Clinical course of the first Asian family with Parkinsonism related to SNCA triplication.
Movement disorders : official journal of the Movement Disorder Society 2010;25(16):2871-5.
2010: Kotaro Ogaki; Kazuyuki Noda; Jiro Fukae; Tsuyoshi Furuya; Takashi Hirayama; Kenji Fujishima; Nobutaka Hattori; Yasuyuki Okuma
[Cryptococcal meningitis successfully treated with liposomal amphotericin B and voriconazole in an elderly patient].
Brain and nerve = Shinkei kenkyū no shinpo 2010;62(12):1337-40.
2010: Nobutaka Hattori
[Molecular genetics of familial Parkinson's disease].
Rinshō shinkeigaku = Clinical neurology 2010;50(11):863.
2010: Momo Tani; Hideki Hayakawa; Toru Yasuda; Tomoko Nihira; Nobutaka Hattori; Yoshikuni Mizuno; Hideki Mochizuki
Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone.
Journal of neurochemistry 2010;115(4):854-63.
2010: Manabu Funayama; Hiroyuki Tomiyama; Ruey-Meei Wu; Kotaro Ogaki; Hiroyo Yoshino; Yoshikuni Mizuno; Nobutaka Hattori
Rapid screening of ATP13A2 variant with high-resolution melting analysis.
Movement disorders : official journal of the Movement Disorder Society 2010;25(14):2434-7.
2010: Hiroyo Yoshino; Hiroyuki Tomiyama; N Tachibana; K Ogaki; Yuanzhe Li; Manabu Funayama; T Hashimoto; S Takashima; Nobutaka Hattori
Phenotypic spectrum of patients with PLA2G6 mutation and PARK14-linked parkinsonism.
Neurology 2010;75(15):1356-61.
2010: Genko Oyama; Kenji Yoshimi; Shihoko Natori; Yoko Chikaoka; Yong-Ri Ren; Manabu Funayama; Yasushi Shimo; Ryosuke Takahashi; Taizo Nakazato; Shigeru Kitazawa; Nobutaka Hattori
Impaired in vivo dopamine release in parkin knockout mice.
Brain research 2010;1352():214-22.
2010: Sumihiro Kawajiri; Yutaka Machida; Shinji Saiki; Shigeto Sato; Nobutaka Hattori
Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.
Neuroscience letters 2010;481(2):88-91.
2010: Nobukazu Miyamoto; Yasutaka Tanaka; Yuji Ueno; Ryota Tanaka; Nobutaka Hattori; Takao Urabe
Comparison of clinical backgrounds with anterior versus posterior circulation infarcts.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2010;19(5):393-7.
2010: Lin Li; Manabu Funayama; Hiroyuki Tomiyama; Yuanzhe Li; Hiroyo Yoshino; Ryogen Sasaki; Yasumasa Kokubo; Shigeki Kuzuhara; Yoshikuni Mizuno; Nobutaka Hattori
No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients.
Neuroscience letters 2010;479(3):245-8.
2010: Jun Mitsui; Yuji K Takahashi; Jun Goto; Hiroyuki Tomiyama; Shunpei Ishikawa; Hiroyo Yoshino; Narihiro Minami; David I Smith; Suzanne Lesage; Hiroyuki Aburatani; Ichizo Nishino; Alexis Brice; Nobutaka Hattori; Shoji Tsuji
Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines.
American journal of human genetics 2010;87(1):75-89.
2010: Zhuo Xu; Naoki Ichikawa; Keisuke Kosaki; Yoshihiko Yamada; Takako Sasaki; Lynn Y Sakai; Hisashi Kurosawa; Nobutaka Hattori; Eri Arikawa-Hirasawa
Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(6):461-70.
2010: Hiromi Shiotsuki; Kenji Yoshimi; Yasushi Shimo; Manabu Funayama; Yukio Takamatsu; Kazutaka Ikeda; Ryosuke Takahashi; Shigeru Kitazawa; Nobutaka Hattori
A rotarod test for evaluation of motor skill learning.
Journal of neuroscience methods 2010;189(2):180-5.
2010: Suzanne Lesage; Etienne Patin; Christel Condroyer; Anne-Louise Leutenegger; Ebba Lohmann; Nir Giladi; Anat Bar-Shira; Soraya Belarbi; Nassima Hecham; Pierre Pollak; Anne-Marie Ouvrard-Hernandez; Soraya Bardien; Jonathan Carr; Traki Benhassine; Hiroyuki Tomiyama; Caroline Pirkevi; Tarik Hamadouche; Cécile Cazeneuve; A Nazli Basak; Nobutaka Hattori; Alexandra Dürr; Meriem Tazir; Avi Orr-Urtreger; Lluis Quintana-Murci; Alexis Brice
Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans.
Human molecular genetics 2010;19(10):1998-2004.
2010: Noriyuki Matsuda; Shigeto Sato; Kahori Shiba; Kei Okatsu; Keiko Saisho; Clement A Gautier; Yu-Shin Sou; Shinji Saiki; Sumihiro Kawajiri; Fumiaki Sato; Mayumi Kimura; Masaaki Komatsu; Nobutaka Hattori; Keiji Tanaka
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
The Journal of cell biology 2010;189(2):211-21.
2010: Sumihiro Kawajiri; Shinji Saiki; Shigeto Sato; Fumiaki Sato; Taku Hatano; Hiroto Eguchi; Nobutaka Hattori
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.
FEBS letters 2010;584(6):1073-9.
2010: Tadaaki Kawanabe; Asako Yoritaka; Hideki Shimura; Hideki Oizumi; Shigeki Tanaka; Nobutaka Hattori
Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia.
Progress in neuro-psychopharmacology & biological psychiatry 2010;34(2):284-7.
2010: Nobukazu Miyamoto; Ryota Tanaka; Hideki Shimura; Terubumi Watanabe; Hideo Mori; Masafumi Onodera; Hideki Mochizuki; Nobutaka Hattori; Takao Urabe
Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(2):299-310.
2010: Jiro Fukae; Shigeki Tanaka; Nobutaka Hattori
Retroperitoneal fibrosis secondary to pergolide therapy.
Internal medicine (Tokyo, Japan) 2010;49(15):1687.
2010: Kazuyuki Noda; Momo Tani; Jiro Fukae; Kenji Fujishima; Nobutaka Hattori; Yasuyuki Okuma
Isolated proximal leg paresis due to a small cortical infarction.
Internal medicine (Tokyo, Japan) 2010;49(15):1633-6.
2010: Yuji Ueno; Yoshiaki Shimada; Ryota Tanaka; Nobukazu Miyamoto; Yasutaka Tanaka; Nobutaka Hattori; Takao Urabe
Patent foramen ovale with atrial septal aneurysm may contribute to white matter lesions in stroke patients.
Cerebrovascular diseases (Basel, Switzerland) 2010;30(1):15-22.
2010: Jiro Fukae; Kazuyuki Noda; Kenji Fujishima; Toshiyuki Takahashi; Nobutaka Hattori; Yasuyuki Okuma
Subacute longitudinal myelitis associated with Behcet's disease.
Internal medicine (Tokyo, Japan) 2010;49(4):343-7.
2009: Kotaro Ogaki; Jiro Fukae; Kazuyuki Noda; Kenji Fujishima; Nobutaka Hattori; Yasuyuki Okuma
Blurred vision with acute hypertension indicating hypertensive brainstem encephalopathy-case report-.
Neurologia medico-chirurgica 2009;49(12):625-30.
2009: Wataru Satake; Yuko Nakabayashi; Ikuko Mizuta; Yushi Hirota; Chiyomi Ito; Michiaki Kubo; Takahisa Kawaguchi; Tatsuhiko Tsunoda; Masahiko Watanabe; Atsushi Takeda; Hiroyuki Tomiyama; Kenji Nakashima; Kazuko Hasegawa; Fumiya Obata; Takeo Yoshikawa; Hideshi Kawakami; Saburo Sakoda; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Yusuke Nakamura; Tatsushi Toda
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
Nature genetics 2009;41(12):1303-7.
2009: Taku Hatano; Shin-Ichiro Kubo; Shigeto Sato; Nobutaka Hattori
Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease.
Journal of neurochemistry 2009;111(5):1075-93.
2009: Kenji Yatomi; Nobukazu Miyamoto; Miki Komine-Kobayashi; Meizi Liu; Hidenori Oishi; Hajime Arai; Nobutaka Hattori; Takao Urabe
Pathophysiological dual action of adiponectin after transient focal ischemia in mouse brain.
Brain research 2009;1297():169-76.
2009: Shuichi Asakawa; Nobutaka Hattori; Atsushi Shimizu; Yoshiko Shimizu; Shinsei Minoshima; Yoshikuni Mizuno; Nobuyoshi Shimizu
Analysis of eighteen deletion breakpoints in the parkin gene.
Biochemical and biophysical research communications 2009;389(1):181-6.
2009: Nobukazu Miyamoto; Ryota Tanaka; Tatsuo Shimosawa; Yutaka Yatomi; Toshiro Fujita; Nobutaka Hattori; Takao Urabe
Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(11):1769-79.
2009: Masahiro Iijima; M Tomita; S Morozumi; Y Kawagashira; T Nakamura; Haruki Koike; Masahisa Katsuno; Nobutaka Hattori; Fumiaki Tanaka; Masayuki Yamamoto; Gen Sobue
Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.
Neurology 2009;73(17):1348-52.
2009: Yasuyuki Okuma; Satoshi Kamei; Akihiko Morita; Fumihito Yoshii; Toshimasa Yamamoto; Shiori Hashimoto; Hiroya Utsumi; Taku Hatano; Nobutaka Hattori; Miyuki Matsumura; Kazushi Takahashi; Shigeru Nogawa; Yuka Watanabe; Tomoyuki Miyamoto; Masayuki Miyamoto; Koichi Hirata
Fatigue in Japanese patients with Parkinson's disease: a study using Parkinson fatigue scale.
Movement disorders : official journal of the Movement Disorder Society 2009;24(13):1977-83.
2009: Meizi Liu; N Eguchi; Y Yamasaki; Y Urade; Nobutaka Hattori; Takao Urabe
Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice.
Neuroscience 2009;163(1):296-307.
2009: Kenya Nishioka; Owen A Ross; Kenji Ishii; Jennifer Kachergus; Kiichi Ishiwata; Mayumi Kitagawa; Satoshi Kono; Tomokazu Obi; Koichi Mizoguchi; Yuichi Inoue; H Imai; Masashi Takanashi; Yoshikuni Mizuno; Matthew J Farrer; Nobutaka Hattori
Expanding the clinical phenotype of SNCA duplication carriers.
Movement disorders : official journal of the Movement Disorder Society 2009;24(12):1811-9.
2009: Shinji Saiki; Yuji Ueno; Toshio Moritani; Takeshi Sato; Takeshi Sekine; Sumihiro Kawajiri; Satoshi Adachi; Kazumasa Yokoyama; Yuji Tomizawa; Yumiko Motoi; Nobutaka Hattori
Extensive hemispheric lesions with radiological evidence of blood-brain barrier integrity in a patient with neuromyelitis optica.
Journal of the neurological sciences 2009;284(1-2):217-9.
2009: Sayaka Funabe; Ryota Tanaka; Takao Urabe; Seiji Kawasaki; Keiko Kobayashi; Nobutaka Hattori
[A case of adult-onset type II citrullinemia with repeated nonconvulsive status epilepticus].
Rinshō shinkeigaku = Clinical neurology 2009;49(9):571-5.
2009: N Miyamoto; Ryota Tanaka; Ning Zhang; H Shimura; M Onodera; Hideki Mochizuki; Nobutaka Hattori; Takao Urabe
Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion.
Neuroscience 2009;162(2):525-36.
2009: Y Ueno; Ning Zhang; N Miyamoto; Ryota Tanaka; Nobutaka Hattori; Takao Urabe
Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model.
Neuroscience 2009;162(2):317-27.
2009: Shinji Saiki; Takeshi Sekine; Yuji Ueno; Hiroyo Yoshino; Junko Takahashi; Yoshihiko Tani; Yasunori Kambe; Yumiko Motoi; Nobutaka Hattori
[Adult-onset case of idiopathic neurodegeneration with brain iron accumulation without mutations in the PANK2 and PLA2G6 genes].
Rinshō shinkeigaku = Clinical neurology 2009;49(8):474-8.
2009: Kuniaki Tatsuta; Shusuke Yoshihara; Nobutaka Hattori; Shinpei Yoshida; Seijiro Hosokawa
The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities.
The Journal of antibiotics 2009;62(8):469-70.
2009: Kazuaki Kanai; Masato Asahina; Kimihito Arai; Hiroyuki Tomiyama; Yoichi Kuwabara; Tomoyuki Uchiyama; Yukari Sekiguchi; Manabu Funayama; Satoshi Kuwabara; Nobutaka Hattori; Takamichi Hattori
Preserved cardiac (123)I-MIBG uptake and lack of severe autonomic dysfunction in a PARK9 patient.
Movement disorders : official journal of the Movement Disorder Society 2009;24(9):1403-4.
2009: Kumi Sasaki; Hideki Shimura; Masako Itaya; Ryota Tanaka; Hideo Mori; Yoshikuni Mizuno; Kenneth S Kosik; Shigeki Tanaka; Nobutaka Hattori
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
FEBS letters 2009;583(13):2194-200.
2009: C Pirkevi; S Lesage; C Condroyer; H Tomiyama; Nobutaka Hattori; S Ertan; Alexis Brice; A N Başak
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype.
Neurogenetics 2009;10(3):271-3.
2009: Kahori Shiba; Takeo Arai; Shigeto Sato; Shin-ichiro Kubo; Yusuke Ohba; Yoshikuni Mizuno; Nobutaka Hattori
Parkin stabilizes PINK1 through direct interaction.
Biochemical and biophysical research communications 2009;383(3):331-5.
2009: Shinji Saiki; Nobutaka Hattori
[Molecular genetics and pathogenesis of Parkinson disease].
No shinkei geka. Neurological surgery 2009;37(6):531-41.
2009: Hiroyuki Tomiyama; Yuanzhe Li; Hiroyo Yoshino; Yoshikuni Mizuno; Shin-Ichiro Kubo; Tatsushi Toda; Nobutaka Hattori
Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism.
Neuroscience letters 2009;455(3):159-61.
2009: T Hatano; S-I Kubo; Y Shimo; K Nishioka; Nobutaka Hattori
Unmet needs of patients with Parkinson's disease: interview survey of patients and caregivers.
The Journal of international medical research 2009;37(3):717-26.
2009: Jun Mitsui; Ikuko Mizuta; Atsushi Toyoda; Ryo Ashida; Yuji K Takahashi; Jun Goto; Yoko Fukuda; Hidetoshi Date; Atsushi Iwata; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Tatsushi Toda; Shoji Tsuji
Mutations for Gaucher disease confer high susceptibility to Parkinson disease.
Archives of neurology 2009;66(5):571-6.
2009: Shihoko Natori; Kenji Yoshimi; Toshimitsu Takahashi; Maki Kagohashi; Genko Oyama; Yasushi Shimo; Nobutaka Hattori; Shigeru Kitazawa
Subsecond reward-related dopamine release in the mouse dorsal striatum.
Neuroscience research 2009;63(4):267-72.
2009: Takao Urabe; Hirotaka Watada; Yasuyuki Okuma; Ryota Tanaka; Yuji Ueno; Nobukazu Miyamoto; Yasutaka Tanaka; Nobutaka Hattori; Ryuzo Kawamori
Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients.
Stroke; a journal of cerebral circulation 2009;40(4):1289-95.
2009: Genko Oyama; Akito Hayashi; Yoshikuni Mizuno; Nobutaka Hattori
Mechanism and treatment of dropped head syndrome associated with parkinsonism.
Parkinsonism & related disorders 2009;15(3):181-6.
2009: Jiro Fukae; Shigeto Sato; Kahori Shiba; Ken-ichi Sato; Hideo Mori; Philip A Sharp; Yoshikuni Mizuno; Nobutaka Hattori
Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.
FEBS letters 2009;583(3):521-5.
2009: R Kamigaichi; S Kubo; K Ishikawa; K Yokoyama; K Ogaki; C Usui; K Hatta; Heii Arai; H Mochizuki; Nobutaka Hattori
Effective control of catatonia in Parkinson's disease by electroconvulsive therapy: a case report.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2009;16(2):e6.
2009: Toru Yasuda; Tomoko Nihira; Yong-Ri Ren; Xu-Qing Cao; Keiichiro Wada; Rieko Setsuie; Tomohiro Kabuta; Keiichiro Wada; Nobutaka Hattori; Yoshikuni Mizuno; Hideki Mochizuki
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.
Journal of neurochemistry 2009;108(4):932-44.
2009: Kazunari Momma; Manabu Funayama; Yuanzhe Li; Hiroshi Ichinose; Kazuo Motoyoshi; Nobutaka Hattori; Yoshikuni Mizuno; Keiko Kamakura
A new mutation in the GCH1 gene presents as early-onset Parkinsonism.
Parkinsonism & related disorders 2009;15(2):160-1.
2009: George D Mellick; Gerhard A Siebert; Manabu Funayama; Daniel D Buchanan; Yuanzhe Li; Yoko Imamichi; Hiroyo Yoshino; Peter A Silburn; Nobutaka Hattori
Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia.
Parkinsonism & related disorders 2009;15(2):105-9.
2009: Naoki Ichikawa; Kazuhisa Iwabuchi; Hidetake Kurihara; Kumiko Ishii; Toshihide Kobayashi; Takako Sasaki; Nobutaka Hattori; Yoshikuni Mizuno; Kentaro Hozumi; Yoshihiko Yamada; Eri Arikawa-Hirasawa
Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.
Journal of cell science 2009;122(Pt 2):289-99.
2009: Yuji Tomizawa; Jiro Fukae; Kazuyuki Noda; Kenji Fujishima; Kazumasa Yokoyama; Nobutaka Hattori; Toshiyuki Takahashi; Yasuyuki Okuma
Linear medullary pericanal lesion with longitudinal myelitis can be diagnostic of neuromyelitis optica.
Internal medicine (Tokyo, Japan) 2009;48(3):175-6.
2009: Asako Yoritaka; Hideki Ohizumi; Shigeki Tanaka; Nobutaka Hattori
Parkinson's disease with and without REM sleep behaviour disorder: are there any clinical differences?
European neurology 2009;61(3):164-70.
2009: Katsumi Miyauchi; Norihide Takaya; Takahisa Hirose; Fuki Ikeda; Ryuzo Kawamori; Hidenori Ohishi; Kensaku Yoshida; Munetaka Yamamoto; Hajime Arai; Takao Urabe; Nobutaka Hattori; Michimasa Suzuki; Tadayuki Maehara; Kazuhiro Sase; Thomas S Hatsukami; Chun Yuan; Hiroyuki Daida
Rationale and design of the carotid plaque in human for all evaluations with aggressive rosuvastatin therapy (CHALLENGER trial): evaluation by magnetic resonance imaging.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(1):111-5.
2009: Takuro Arimura; Yukiko K Hayashi; Terumi Murakami; Yasushi Oya; Sayaka Funabe; Eri Arikawa-Hirasawa; Nobutaka Hattori; Ichizo Nishino; Akinori Kimura
Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(1):158-61.
2009: Keisuke Suzuki; Masayuki Miyamoto; Tomoyuki Miyamoto; Yasuyuki Okuma; Nobutaka Hattori; Satoshi Kamei; Fumihito Yoshii; Hiroya Utsumi; Yasuo Iwasaki; Mutsumi Iijima; Koichi Hirata
Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson's disease.
Parkinsonism & related disorders 2009;15(1):15-9.
2008: Hiroyuki Tomiyama; Yasumasa Kokubo; Ryogen Sasaki; Yuanzhe Li; Yoko Imamichi; Manabu Funayama; Yoshikuni Mizuno; Nobutaka Hattori; Shigeki Kuzuhara
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.
Movement disorders : official journal of the Movement Disorder Society 2008;23(16):2344-8.
2008: Francisco J Diaz-Corrales; Masato Asanuma; Ikuko Miyazaki; Ko Miyoshi; Nobutaka Hattori; Norio Ogawa
Dopamine induces supernumerary centrosomes and subsequent cell death through Cdk2 up-regulation in dopaminergic neuronal cells.
Neurotoxicity research 2008;14(4):295-305.
2008: Nobutaka Hattori
[Recent progress in Parkinson's disease].
Rinshō shinkeigaku = Clinical neurology 2008;48(11):980.
2008: Baek-Soo Han; Lorraine Iacovitti; Taku Katano; Nobutaka Hattori; Wongi Seol; Kwang-Soo Kim
Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra.
Neuroscience letters 2008;442(3):190-4.
2008: Hiroshi Yamashita; Tatsuo Kohriyama; Tomohiko Ohshita; Tetsuya Takahashi; Kazuo Hashikawa; Nobutaka Hattori; Hidenao Fukuyama; Masayasu Matsumoto
[Case of a 30-year history of PARK6 --findings from functional imaging of the brain].
Rinshō shinkeigaku = Clinical neurology 2008;48(9):662-5.
2008: Keisuke Suzuki; Tomoyuki Miyamoto; Masayuki Miyamoto; Yasuyuki Okuma; Nobutaka Hattori; Satoshi Kamei; Fumihito Yoshii; Hiroya Utsumi; Yasuo Iwasaki; Mutsumi Iijima; Koichi Hirata
Excessive daytime sleepiness and sleep episodes in Japanese patients with Parkinson's disease.
Journal of the neurological sciences 2008;271(1-2):47-52.
2008: Ikuko Mizuta; Tatsuhiko Tsunoda; Wataru Satake; Yuko Nakabayashi; Masahiko Watanabe; Atsushi Takeda; Kazuko Hasegawa; Kenji Nakashima; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Tatsushi Toda
Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.
Human genetics 2008;124(1):89-94.
2008: Manabu Funayama; Yuanzhe Li; Tak-Hong Tsoi; Ching-Wan Lam; Takekazu Ohi; Shogo Yazawa; Eiichiro Uyama; Ruth Djaldetti; Eldad Melamed; Hiroyo Yoshino; Yoko Imamichi; Hiroshi Takashima; Kenya Nishioka; Kenichi Sato; Hiroyuki Tomiyama; Shin-Ichiro Kubo; Yoshikuni Mizuno; Nobutaka Hattori
Familial Parkinsonism with digenic parkin and PINK1 mutations.
Movement disorders : official journal of the Movement Disorder Society 2008;23(10):1461-5.
2008: Nobukazu Miyamoto; Ning Zhang; Ryota Tanaka; Meizi Liu; Nobutaka Hattori; Takao Urabe
Neuroprotective role of angiotensin II type 2 receptor after transient focal ischemia in mice brain.
Neuroscience research 2008;61(3):249-56.
2008: Owen A Ross; Yih-Ru Wu; Mei-Ching Lee; Manabu Funayama; Meng-Ling Chen; Alexandra I Soto; Ignacio Mata; Guey-Jen Lee-Chen; Chiung-Mei Chen; Michelle Tang; Yi Zhao; Nobutaka Hattori; Matthew J Farrer; Eng-King Tan; Ruey-Meei Wu
Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.
Annals of neurology 2008;64(1):88-92.
2008: Yoshikuni Mizuno; Nobutaka Hattori; Shin-Ichiro Kubo; Shigeto Sato; Kenya Nishioka; Taku Hatano; Hiroyuki Tomiyama; Manabu Funayama; Yutaka Machida; Hideki Mochizuki
Progress in the pathogenesis and genetics of Parkinson's disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1500):2215-27.
2008: Narae Shin; Hyerhan Jeong; Jungsun Kwon; Hye Young Heo; Jung June Kwon; Hye Jin Yun; Cy-Hyun Kim; Baek Soo Han; Youren Tong; Jie Shen; Taku Hatano; Nobutaka Hattori; Kwang-Soo Kim; Sunghoe Chang; Wongi Seol
LRRK2 regulates synaptic vesicle endocytosis.
Experimental cell research 2008;314(10):2055-65.
2008: Owen A Ross; Adam T Braithwaite; Lisa Skipper; Jennifer Kachergus; Mary Hulihan; Frank A Middleton; Kenya Nishioka; Julia Fuchs; Thomas Gasser; Demetrius M Maraganore; Charles H Adler; Lydie Larvor; Marie-Christine Chartier-Harlin; Christer Nilsson; J William Langston; Katrina Gwinn-Hardy; Nobutaka Hattori; Matthew J Farrer
Genomic investigation of alpha-synuclein multiplication and parkinsonism.
Annals of neurology 2008;63(6):743-50.
2008: Ryuya Kumazawa; Hiroyuki Tomiyama; Yuanzhe Li; Yoko Imamichi; Manabu Funayama; Hiroyo Yoshino; Fusako Yokochi; Toshihiro Fukusako; Yasushi Takehisa; Kenichi Kashihara; Tomoyoshi Kondo; Bulent Elibol; Sevasti Bostantjopoulou; Tatsushi Toda; Hirohide Takahashi; Fumihito Yoshii; Yoshikuni Mizuno; Nobutaka Hattori
Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease.
Archives of neurology 2008;65(6):802-8.
2008: Kazuo Yamashiro; Miki Komine-Kobayashi; Taku Hatano; Takao Urabe; Hideki Mochizuki; Nobutaka Hattori; Yoshitaka Iwama; Hiroyuki Daida; Michi Sakai; Takeo Nakayama; Yoshikuni Mizuno
The frequency of cardiac valvular regurgitation in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2008;23(7):935-41.
2008: Daniel Kam Yin Chan; Vincent Mok; Ping-Wing Ng; Jonas Yeung; John B Kwok; Zhi Fang; Raymond Clarke; Lawrence Wong; Peter R Schofield; Nobutaka Hattori
PARK2 mutations and clinical features in a Chinese population with early-onset Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(5):715-9.
2008: Y P Ning; K Kanai; Hiroyuki Tomiyama; Yuanzhe Li; Manabu Funayama; Hiroyo Yoshino; Shigeto Sato; Masato Asahina; S Kuwabara; Atsushi Takeda; T Hattori; Yoshikuni Mizuno; Nobutaka Hattori
PARK9-linked parkinsonism in eastern Asia: mutation detection in ATP13A2 and clinical phenotype.
Neurology 2008;70(16 Pt 2):1491-3.
2008: T Hirayama; Jiro Fukae; K Noda; Kenji Fujishima; T Yamamoto; K Mori; M Maeda; Nobutaka Hattori; N Shiroma; S Tsurui; Y Okuma
Adult-onset Alexander disease with palatal myoclonus and intraventricular tumour.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2008;15(2):e16-7.
2008: Tomokazu Obi; K Nishioka; O A Ross; T Terada; K Yamazaki; A Sugiura; M Takanashi; Kouichi Mizoguchi; H Mori; Yoshikuni Mizuno; Nobutaka Hattori
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.
Neurology 2008;70(3):238-41.
2008: Hiroyuki Tomiyama; Ikuko Mizuta; Yuanzhe Li; Manabu Funayama; Hiroyo Yoshino; Lin Li; Miho Murata; Mitsutoshi Yamamoto; Shin-Ichiro Kubo; Yoshikuni Mizuno; Tatsushi Toda; Nobutaka Hattori
LRRK2 P755L variant in sporadic Parkinson's disease.
Journal of human genetics 2008;53(11-12):1012-5.
2008: Maki Kagohashi; Taizo Nakazato; Kenji Yoshimi; Shunjiro Moizumi; Nobutaka Hattori; Shigeru Kitazawa
Wireless voltammetry recording in unanesthetised behaving rats.
Neuroscience research 2008;60(1):120-7.
2008: Shin-Ichiro Kubo; Akira Iwatake; Nobuyuki Ebihara; Akira Murakami; Nobutaka Hattori
Visual impairment in Parkinson's disease treated with amantadine: case report and review of the literature.
Parkinsonism & related disorders 2008;14(2):166-9.
2007: Jiro Fukae; Kazuyuki Noda; Kenji Fujishima; Ryo Wada; Takashi Yoshiike; Nobutaka Hattori; Yasuyuki Okuma
Successful treatment of relapsing neuro-Sweet's disease with corticosteroid and dapsone combination therapy.
Clinical neurology and neurosurgery 2007;109(10):910-3.
2007: Akane Suzuki; Tribidasari A Ivandini; Kenji Yoshimi; Akira Fujishima; Genko Oyama; Taizo Nakazato; Nobutaka Hattori; Shigeru Kitazawa; Yasuaki Einaga
Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection.
Analytical chemistry 2007;79(22):8608-15.
2007: Nobutaka Hattori; Shin-ichiro Kubo
[The pathogenesis of Parkinson's disease: a hint from insights of familial Parkinson's disease].
Rinshō shinkeigaku = Clinical neurology 2007;47(11):774-8.
2007: Nobutaka Hattori; Shigeto Sato
Animal models of Parkinson's disease: similarities and differences between the disease and models.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(5):479-83.
2007: Sumihiro Kawajiri; Momo Tani; Kazuyuki Noda; Kenji Fujishima; Nobutaka Hattori; Yasuyuki Okuma
Segmental zoster paresis of limbs: report of three cases and review of literature.
The neurologist 2007;13(5):313-7.
2007: Yuji Ueno; Kazumi Kimura; Yasuyuki Iguchi; Kensaku Shibazaki; Takeshi Inoue; Nobutaka Hattori; Takao Urabe
Mobile aortic plaques are a cause of multiple brain infarcts seen on diffusion-weighted imaging.
Stroke; a journal of cerebral circulation 2007;38(9):2470-6.
2007: Nobutaka Hattori
[Neuromuscular disorders due to adverse effects of antiparkinson agents].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2007;96(8):1614-20.
2007: Hiroyuki Tomiyama; Taku Hatano; Nobutaka Hattori
[Clinical molecular genetics for PARK8 (LRRK2)].
Brain and nerve = Shinkei kenkyū no shinpo 2007;59(8):839-50.
2007: Manabu Funayama; Nobutaka Hattori
[Molecular genetics of PINK1].
Brain and nerve = Shinkei kenkyū no shinpo 2007;59(8):831-8.
2007: Kenya Nishioka; Nobutaka Hattori
[Relationship between alpha-synuclein and Parkinson's disease].
Brain and nerve = Shinkei kenkyū no shinpo 2007;59(8):825-30.
2007: Toru Yasuda; Momo Fukuda-Tani; Tomoko Nihira; Keiichiro Wada; Nobutaka Hattori; Yoshikuni Mizuno; Hideki Mochizuki
Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease.
Experimental neurology 2007;206(2):308-17.
2007: Keisuke Suzuki; Yasuyuki Okuma; Nobutaka Hattori; Satoshi Kamei; Fumihito Yoshii; Hiroya Utsumi; Yasuo Iwasaki; Mutsumi Iijima; Tomoyuki Miyamoto; Masayuki Miyamoto; Koichi Hirata
Characteristics of sleep disturbances in Japanese patients with Parkinson's disease. A study using Parkinson's disease sleep scale.
Movement disorders : official journal of the Movement Disorder Society 2007;22(9):1245-51.
2007: Kazuo Yamashiro; R Liu; M Maeda; Nobutaka Hattori; Takao Urabe
Induction and selective accumulation of mutant ubiquitin in CA1 pyramidal neurons after transient global ischemia.
Neuroscience 2007;147(1):71-9.
2007: Wataru Satake; Ikuko Mizuta; Satoko Suzuki; Yuko Nakabayashi; Chiyomi Ito; Masahiko Watanabe; Atsushi Takeda; Kazuko Hasegawa; Saburo Sakoda; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Tatsushi Toda
Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.
Neuroreport 2007;18(9):937-40.
2007: Wakako Tamo; Tadaatsu Imaizumi; Kunikazu Tanji; Hidemi Yoshida; Shingo Takanashi; Koichi Wakabayashi; Ryosuke Takahashi; Nobutaka Hattori; Kei Satoh
Parkin is expressed in vascular endothelial cells.
Neuroscience letters 2007;419(3):199-201.
2007: Misuzu Saiki; Shinji Saiki; Koichiro Sakai; Ichiro Matsunari; Kotaro Higashi; Ken-Ya Murata; Nobutaka Hattori; Genjiro Hirose
Neurological deficits are associated with increased brain calcinosis, hypoperfusion, and hypometabolism in idiopathic basal ganglia calcification.
Movement disorders : official journal of the Movement Disorder Society 2007;22(7):1027-30.
2007: Shinji Saiki; Koichiro Sakai; Ken-ya Murata; Misuzu Saiki; Megumi Nakanishi; Yoko Kitagawa; Muichi Kaito; Yuichiro Gondo; Toshihide Kumamoto; Makoto Matsui; Nobutaka Hattori; Genjiro Hirose
Primary skeletal muscle involvement in chorea-acanthocytosis.
Movement disorders : official journal of the Movement Disorder Society 2007;22(6):848-52.
2007: Yukiko Takata; Kazuyuki Noda; Kenji Fujishima; Nobutaka Hattori; Yoshikuni Mizuno; Yasuyuki Okuma
[A case of neuralgic amyotrophy in the lower extremity (lumbosacral radiculoplexus neuropathy)].
Brain and nerve = Shinkei kenkyū no shinpo 2007;59(4):435-8.
2007: M Liu; N Eguchi; Y Yamasaki; Y Urade; Nobutaka Hattori; Takao Urabe
Focal cerebral ischemia/reperfusion injury in mice induces hematopoietic prostaglandin D synthase in microglia and macrophages.
Neuroscience 2007;145(2):520-9.
2007: Taku Hatano; Shin-Ichiro Kubo; Satoshi Imai; Masahiro Maeda; Kiyoshi Ishikawa; Yoshikuni Mizuno; Nobutaka Hattori
Leucine-rich repeat kinase 2 associates with lipid rafts.
Human molecular genetics 2007;16(6):678-90.
2007: Lilach Ephraty; Omer Porat; David Israeli; Oren S Cohen; Olga Tunkel; Shinar Yael; Yasuko Hatano; Nobutaka Hattori; Sharon Hassin-Baer
Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations.
Movement disorders : official journal of the Movement Disorder Society 2007;22(4):566-9.
2007: Masafumi Ihara; Nobuyuki Yamasaki; Akari Hagiwara; Ai Tanigaki; Ayumi Kitano; Rie Hikawa; Hidekazu Tomimoto; Makoto Noda; Masashi Takanashi; Hideo Mori; Nobutaka Hattori; Tsuyoshi Miyakawa; Makoto Kinoshita
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.
Neuron 2007;53(4):519-33.
2007: Manabu Funayama; Yuanzhe Li; Hiroyuki Tomiyama; Hiroyo Yoshino; Yoko Imamichi; Mitsutoshi Yamamoto; Miho Murata; Tatsushi Toda; Yoshikuni Mizuno; Nobutaka Hattori
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
Neuroreport 2007;18(3):273-5.
2007: Jiro Fukae; Yoshikuni Mizuno; Nobutaka Hattori
Mitochondrial dysfunction in Parkinson's disease.
Mitochondrion 2007;7(1-2):58-62.
2007: Satoshi Kono; Kentaro Shirakawa; Yasuomi Ouchi; Masanobu Sakamoto; Hiroyuki Ida; Takeshi Sugiura; Hiroyuki Tomiyama; Hitoshi Suzuki; Yoshitomo Takahashi; Hiroaki Miyajima; Nobutaka Hattori; Yoshikuni Mizuno
Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier.
Journal of the neurological sciences 2007;252(2):181-4.
2007: Yoshikuni Mizuno; Nobutaka Hattori; Hideki Mochizuki
Genetic aspects of Parkinson's disease.
Handbook of clinical neurology 2007;83():217-44.
2007: Momo Tani; Shihoko Natori; Kazuyuki Noda; Kenji Fujishima; Nobutaka Hattori; Yoshikuni Mizuno; Yasuyuki Okuma
Isolated reversible splenial lesion in adult meningitis: a case report and review of the literature.
Internal medicine (Tokyo, Japan) 2007;46(18):1597-600.
2007: Lianna Ishihara; Rachel A Gibson; Liling Warren; Rim Amouri; Kelly E Lyons; Catherine Wielinski; Christine Hunter; Jina Swartz; Ramu Elango; P Anthony Akkari; David Leppert; Linda Surh; Kevin H Reeves; Siwan Thomas; Leigh Ragone; Nobutaka Hattori; Rajesh Pahwa; Joseph Jankovic; Martha Nance; Alan Freeman; Neziha Gouider-Khouja; Mounir Kefi; Mourad Zouari; Samia Ben Sassi; Samia Ben Yahmed; Ghada El Euch-Fayeche; Lefkos T Middleton; David J Burn; Ray L Watts; Faycal Hentati
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.
Movement disorders : official journal of the Movement Disorder Society 2007;22(1):55-61.
2006: Shigeto Sato; Tomoki Chiba; Shingo Nishiyama; Takeharu Kakiuchi; Hideo Tsukada; Taku Hatano; Takahiro Fukuda; Yasunobu Yasoshima; Nobuyuki Kai; Kazuto Kobayashi; Yoshikuni Mizuno; Keiji Tanaka; Nobutaka Hattori
Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography.
Journal of neuroscience research 2006;84(6):1350-7.
2006: Atsuko Nakamura; Toshiaki Kitami; Hideo Mori; Yoshikuni Mizuno; Nobutaka Hattori
Nuclear localization of the 20S proteasome subunit in Parkinson's disease.
Neuroscience letters 2006;406(1-2):43-8.
2006: Lianna Ishihara; Liling Warren; Rachel Gibson; Rim Amouri; Suzanne Lesage; Alexandra Dürr; Meriem Tazir; Zbigniew K Wszolek; Ryan Uitti; William C Nichols; Alida Griffith; Nobutaka Hattori; David Leppert; Ray L Watts; Cyrus Zabetian; Tatiana Foroud; Matthew J Farrer; Alexis Brice; Lefkos T Middleton; Faycal Hentati
Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.
Archives of neurology 2006;63(9):1250-4.
2006: Kenichi Sato; Taku Hatano; Kazuo Yamashiro; Maki Kagohashi; Kenya Nishioka; Nana Izawa; Hideki Mochizuki; Nobutaka Hattori; Hideo Mori; Yoshikuni Mizuno
Prognosis of Parkinson's disease: time to stage III, IV, V, and to motor fluctuations.
Movement disorders : official journal of the Movement Disorder Society 2006;21(9):1384-95.
2006: Demetrius M Maraganore; Mariza de Andrade; Alexis Elbaz; Matthew J Farrer; John Ioannidis; Rejko Krüger; Walter A Rocca; Nicole K Schneider; Timothy G Lesnick; Sarah J Lincoln; Mary Hulihan; Jan Aasly; Tetsuo Ashizawa; Marie-Christine Chartier-Harlin; Harvey Checkoway; Carlo Ferrarese; Georgios M Hadjigeorgiou; Nobutaka Hattori; Hideshi Kawakami; jean-charles lambert; Timothy Lynch; George D Mellick; Spiridon Papapetropoulos; Abbas Parsian; Aldo Quattrone; Olaf Riess; Eng-King Tan; Christine Van Broeckhoven
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.
JAMA : the journal of the American Medical Association 2006;296(6):661-70.
2006: Takeo Arai; Jiro Fukae; Taku Hatano; Shin-ichiro Kubo; Toshio Ohtsubo; Yusaku Nakabeppu; Hideo Mori; Yoshikuni Mizuno; Nobutaka Hattori
Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease.
Acta neuropathologica 2006;112(2):139-45.
2006: Hiroyuki Tomiyama; Yuanzhe Li; Manabu Funayama; Kazuko Hasegawa; Hiroyo Yoshino; Shin-Ichiro Kubo; Kenichi Sato; Tatsuya Hattori; Chin-Song Lu; Rivka Inzelberg; Ruth Djaldetti; Eldad Melamed; Rim Amouri; Neziha Gouider-Khouja; Faycal Hentati; Yasuko Hatano; Mei Wang; Yoko Imamichi; Koichi Mizoguchi; Hiroaki Miyajima; Fumiya Obata; Tatsushi Toda; Matthew J Farrer; Yoshikuni Mizuno; Nobutaka Hattori
Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.
Movement disorders : official journal of the Movement Disorder Society 2006;21(8):1102-8.
2006: Shin-ichiro Kubo; Nobutaka Hattori; Yoshikuni Mizuno
Recessive Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2006;21(7):885-93.
2006: Mitsugu Akagawa; Sohei Ito; Kazuyo Toyoda; Yoshihisa Ishii; Emi Tatsuda; Takahiro Shibata; Satoru Yamaguchi; Yoshichika Kawai; Kousuke Ishino; Yusuke Kishi; Takahiro Adachi; Takeshi Tsubata; Yoshinari Takasaki; Nobutaka Hattori; Tsukasa Matsuda; Koji Uchida
Bispecific abs against modified protein and DNA with oxidized lipids.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6160-5.
2006: Shoji Yamamoto; Jiro Fukae; Hideo Mori; Yoshikuni Mizuno; Nobutaka Hattori
Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra.
Neuroscience letters 2006;396(3):187-91.
2006: Ikuko Mizuta; Wataru Satake; Yuko Nakabayashi; Chiyomi Ito; Satoko Suzuki; Yoshio Momose; Yoshitaka Nagai; Akira Oka; Hidetoshi Inoko; Jiro Fukae; Yuko Saito; Motoji Sawabe; Shigeo Murayama; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Tatsushi Toda
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.
Human molecular genetics 2006;15(7):1151-8.
2006: Masahiko Atsumi; Yuanzhe Li; Hiroyuki Tomiyama; Kenichi Sato; Nobutaka Hattori
[A 62-year-old woman with early-onset Parkinson's disease associated with the PINKi gene deletion].
Rinshō shinkeigaku = Clinical neurology 2006;46(3):199-202.
2006: Noriyuki Matsuda; Toshiaki Kitami; Toshiaki Suzuki; Yoshikuni Mizuno; Nobutaka Hattori; Keiji Tanaka
Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro.
The Journal of biological chemistry 2006;281(6):3204-9.
2006: Kenya Nishioka; Shin Hayashi; Matthew J Farrer; Andrew Singleton; Hiroyo Yoshino; Hisamasa Imai; Toshiaki Kitami; Kenichi Sato; Ryu Kuroda; Hiroyuki Tomiyama; Koichi Mizoguchi; Miho Murata; Tatsushi Toda; Issei Imoto; Johji Inazawa; Yoshikuni Mizuno; Nobutaka Hattori
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.
Annals of neurology 2006;59(2):298-309.
2006: Makiko-Iijima Kitami; Toshiaki Kitami; Masami Nagahama; Mitsuo Tagaya; Seiji Hori; Akira Kakizuka; Yoshikuni Mizuno; Nobutaka Hattori
Dominant-negative effect of mutant valosin-containing protein in aggresome formation.
FEBS letters 2006;580(2):474-8.
2006: Shigeto Sato; Tomoki Chiba; Eri Sakata; Koichi Kato; Yoshikuni Mizuno; Nobutaka Hattori; Keiji Tanaka
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
The EMBO journal 2006;25(1):211-21.
2006: Nobutaka Hattori; Yutaka Machida; Shigeto Sato; Kazuyuki Noda; M Iijima-Kitami; S i Kubo; Yoshikuni Mizuno
Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins.
Journal of neural transmission. Supplementum 2006;(70):205-8.
2006: Yoshikuni Mizuno; Nobutaka Hattori; Hiroyo Yoshino; Y Hatano; K Satoh; Hiroyuki Tomiyama; Y Li
Progress in familial Parkinson's disease.
Journal of neural transmission. Supplementum 2006;(70):191-204.
2005: Rivka Inzelberg; Nobutaka Hattori; Yoshikuni Mizuno
Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation.
Neurology 2005;65(11):1843.
2005: Hideki Shimura; Hideo Mori; Yasuko Komatsuzaki; Kazuhiro Nakamura; Masashi Takanashi; Nobutaka Hattori; Yoshikuni Mizuno
[A 54-year-old man with familial parkinsonism, gaze palsy, and dementia].
Nō to shinkei = Brain and nerve 2005;57(12):1104-12.
2005: Xiaobing Li; Toshiaki Kitami; Mei Wang; Yoshikuni Mizuno; Nobutaka Hattori
Geographic and ethnic differences in frequencies of two polymorphisms (D/N394 and L/I272) of the parkin gene in sporadic Parkinson's disease.
Parkinsonism & related disorders 2005;11(8):485-91.
2005: Chin-Song Lu; Erik J Simons; Yah-Huei Wu Chou; Alessio Di Fonzo; Hsiu-Chen Chang; Rou-Shayn Chen; Yi-Hsin Weng; Christan F Rohé; Guido J Breedveld; Nobutaka Hattori; Thomas Gasser; Ben A Oostra; Vincenzo Bonifati
The LRRK2 I2012T, G2019S, and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson's disease.
Parkinsonism & related disorders 2005;11(8):521-2.
2005: Nobutaka Hattori; Yutaka Machida; Kazuyuki Noda
[Pathogenesis of Parkinson's disease: a common pathway between alpha-synuclein and parkin and the mechanism of Lewy bodies formation].
Rinshō shinkeigaku = Clinical neurology 2005;45(11):905-7.
2005: Taku Hatano; Masashi Takanashi; Teiko Sumino; Ying Liu; Hideo Mori; Nobutaka Hattori; Yoshikuni Mizuno
[A 73-year-old woman with depression, dementia, and parkinsonism].
Nō to shinkei = Brain and nerve 2005;57(10):907-14.
2005: Masayuki Ide; Kazuo Yamada; Tomoko Toyota; Yoshimi Iwayama; Yuichi Ishitsuka; Yoshio Minabe; Kazuhiko Nakamura; Nobutaka Hattori; Takashi Asada; Yoshikuni Mizuno; Norio Mori; Takeo Yoshikawa
Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease.
Human genetics 2005;117(6):520-7.
2005: Satoshi Orimo; Takeshi Amino; Masayuki Yokochi; Tohru Kojo; Toshiki Uchihara; Atsushi Takahashi; Koichi Wakabayashi; Hitoshi Takahashi; Nobutaka Hattori; Yoshikuni Mizuno
Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2.
Movement disorders : official journal of the Movement Disorder Society 2005;20(10):1350-3.
2005: Shin-ichiro Kubo; Venu M Nemani; Robert J Chalkley; Malcolm D Anthony; Nobutaka Hattori; Yoshikuni Mizuno; Robert H Edwards; Doris L Fortin
A combinatorial code for the interaction of alpha-synuclein with membranes.
The Journal of biological chemistry 2005;280(36):31664-72.
2005: Yuh Machida; Makiko Lijima; Kazuhiro Nakamura; Satoshi Ota; Nobutaka Hattori; Yoshikuni Mizuno
[A 60-year-old man with intention tremor as an initial symptom followed by cerebellar ataxia, peripheral neuropathy and dementia].
Nō to shinkei = Brain and nerve 2005;57(8):710-9.
2005: Jordi Clarimon; Janel Johnson; Ruth Djaldetti; Dena Hernandez; Nobutaka Hattori; Hava Sroka; Yael Barhom; Andrew Singleton
Mutation of the Parkin gene in a Persian family: clinical progression over a 40-year period.
Movement disorders : official journal of the Movement Disorder Society 2005;20(7):887-90.
2005: Yutaka Machida; Tomoki Chiba; Atsushi Takayanagi; Yoshikazu Tanaka; Masato Asanuma; Norio Ogawa; Akihiko Koyama; Takeshi Iwatsubo; Shosuke Ito; Poul Hening Jansen; Nobuyoshi Shimizu; Keiji Tanaka; Yoshikuni Mizuno; Nobutaka Hattori
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.
Biochemical and biophysical research communications 2005;332(1):233-40.
2005: Yuanzhe Li; Hiroyuki Tomiyama; Kenichi Sato; Yasuko Hatano; Hiroyo Yoshino; Masahiko Atsumi; Masataka Kitaguchi; S Sasaki; S Kawaguchi; H Miyajima; Tatsushi Toda; Yoshikuni Mizuno; Nobutaka Hattori
Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism.
Neurology 2005;64(11):1955-7.
2005: Jiro Fukae; Shin-Ichiro Kubo; Nobutaka Hattori; Kaoru Komatsu; Masaaki Kato; Masashi Aoki; Yoshikuni Mizuno
Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2005;6(2):122-4.
2005: Kazuyuki Noda; Toshiaki Kitami; Wei Ping Gai; Fariba Chegini; Poul Henning Jensen; Tsutomu Fujimura; Kimie Murayama; Keiji Tanaka; Yoshikuni Mizuno; Nobutaka Hattori
Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's disease.
Biochemical and biophysical research communications 2005;331(1):309-17.
2005: Masahiko Suzuki; Nobutaka Hattori; Satoshi Orimo; Nobuyoshi Fukumitsu; Masahiro Abo; Yu Kono; Renpei Sengoku; Akira Kurita; Hidehiko Honda; Kiyoharu Inoue
Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: first case report.
Movement disorders : official journal of the Movement Disorder Society 2005;20(5):634-6.
2005: Yasuko Hatano; Gyohyo Ri; Nobutaka Hattori; Yoshikuni Mizuno
[Gene abnormalities in Parkinson disease].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2005;94(4):775-81.
2005: Shigeto Sato; Yoshikuni Mizuno; Nobutaka Hattori
Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease.
Neurology 2005;64(6):1081-3.
2005: Jiro Fukae; Masashi Takanashi; Shin-ichiro Kubo; Ken-ichi Nishioka; Yusaku Nakabeppu; Hideo Mori; Yoshikuni Mizuno; Nobutaka Hattori
Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders.
Acta neuropathologica 2005;109(3):256-62.
2005: Darren J Moore; Li Zhang; Juan C Troncoso; Michael K Lee; Nobutaka Hattori; Yoshikuni Mizuno; Ted M Dawson; Valina Dawson
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.
Human molecular genetics 2005;14(1):71-84.
2004: Tomoo Namihira; Nobutaka Hattori; Seigo Shiroma; Yoshikazu Miyazato
Autosomal recessive juvenile Parkinson's disease with partial trisomy of chromosome 6q syndrome: a case report.
Psychiatry and clinical neurosciences 2004;58(6):672-3.
2004: Keiji Tanaka; Toshiaki Suzuki; Nobutaka Hattori; Yoshikuni Mizuno
Ubiquitin, proteasome and parkin.
Biochimica et biophysica acta 2004;1695(1-3):235-47.
2004: Nobutaka Hattori
[The gene products for familial Parkinson's disease provide us hints to elucidate the mechanisms of nigral degeneration].
Rinshō shinkeigaku = Clinical neurology 2004;44(11):821-3.
2004: Yasuko Hatano; Kenichi Sato; B Elibol; Hiroyo Yoshino; Yasuhiro Yamamura; Vincenzo Bonifati; Hitoshi Shinotoh; Masato Asahina; S Kobayashi; A R Ng; R L Rosales; Sharon Hassin-Baer; Y Shinar; Chin-Song Lu; H C Chang; Yah-Huei Wu Chou; F Belgin Ataç; Tomonori Kobayashi; Tatsushi Toda; Yoshikuni Mizuno; Nobutaka Hattori
PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.
Neurology 2004;63(8):1482-5.
2004: Masashi Tanaka; Vicente M Cabrera; Ana M González; José M Larruga; Takeshi Takeyasu; Noriyuki Fuku; Li-Jun Guo; Raita Hirose; Yasunori Fujita; Miyuki Kurata; Ken-ichi Shinoda; Kazuo Umetsu; Yoshiji Yamada; Yoshiharu Oshida; Yuzo Sato; Nobutaka Hattori; Yoshikuni Mizuno; Yasumichi Arai; Nobuyoshi Hirose; Shigeo Ohta; Osamu Ogawa; Yasushi Tanaka; Ryuzo Kawamori; Masayo Shamoto-Nagai; Wakako Maruyama; Hiroshi Shimokata; Ryota Suzuki; Hidetoshi Shimodaira
Mitochondrial genome variation in eastern Asia and the peopling of Japan.
Genome research 2004;14(10A):1832-50.
2004: Kahori Shiba; Nobutaka Hattori
[Molecular biology for familial Parkinson's disease].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(9):1617-22.
2004: Yasuko Hatano; Yuanzhe Li; Kenichi Sato; Shuichi Asakawa; Yasuhiro Yamamura; Hiroyuki Tomiyama; Hiroyo Yoshino; Masato Asahina; Susumu Kobayashi; Sharon Hassin-Baer; Chin-Song Lu; Arlene R Ng; Raymond L Rosales; Nobuyoshi Shimizu; Tatsushi Toda; Yoshikuni Mizuno; Nobutaka Hattori
Novel PINK1 mutations in early-onset parkinsonism.
Annals of neurology 2004;56(3):424-7.
2004: Nobutaka Hattori; Yoshikuni Mizuno
Pathogenetic mechanisms of parkin in Parkinson's disease.
Lancet 2004;364(9435):722-4.
2004: Youichirou Higashi; Masato Asanuma; Ikuko Miyazaki; Nobutaka Hattori; Yoshikuni Mizuno; Norio Ogawa
Parkin attenuates manganese-induced dopaminergic cell death.
Journal of neurochemistry 2004;89(6):1490-7.
2004: Nobutaka Hattori
[Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].
Rinshō shinkeigaku = Clinical neurology 2004;44(4-5):241-62.
2004: Takashi Nomiyama; Yasushi Tanaka; Lianshan Piao; Nobutaka Hattori; Hiroshi Uchino; Hirotaka Watada; Ryuzo Kawamori; Shigeo Ohta
Accumulation of somatic mutation in mitochondrial DNA and atherosclerosis in diabetic patients.
Annals of the New York Academy of Sciences 2004;1011():193-204.
2004: Demetrius M Maraganore; Timothy G Lesnick; Alexis Elbaz; Marie-Christine Chartier-Harlin; Thomas Gasser; Rejko Krüger; Nobutaka Hattori; George D Mellick; Aldo Quattrone; Jun-Ichi Satoh; Tatsushi Toda; Jian Wang; John Ioannidis; Mariza de Andrade; Walter A Rocca; Taksushi Toda
UCHL1 is a Parkinson's disease susceptibility gene.
Annals of neurology 2004;55(4):512-21.
2003: Yoshito Nagano; Hiroshi Yamashita; Tetsuya Takahashi; Shosei Kishida; Takeshi Nakamura; Eizo Iseki; Nobutaka Hattori; Yoshikuni Mizuno; Akira Kikuchi; Masayasu Matsumoto
Siah-1 facilitates ubiquitination and degradation of synphilin-1.
The Journal of biological chemistry 2003;278(51):51504-14.
2003: Nobutaka Hattori
Appropriate dosing of pergolide in monotherapy and adjunctive therapy in Parkinson's disease.
Current opinion in neurology 2003;16 Suppl 1():S21-5.
2003: Se Jung Kim; Jee Young Sung; Ji Won Um; Nobutaka Hattori; Yoshikuni Mizuno; Keiji Tanaka; Seung R Paik; Jongsun Kim; Kwang Chul Chung
Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain.
The Journal of biological chemistry 2003;278(43):41890-9.
2003: Tatsushi Toda; Yoshio Momose; Miho Murata; Gen Tamiya; Mitsutoshi Yamamoto; Nobutaka Hattori; Hidetoshi Inoko
Toward identification of susceptibility genes for sporadic Parkinson's disease.
Journal of neurology 2003;250 Suppl 3():III40-3.
2003: Nobutaka Hattori; Hirokazu Kobayashi; Yasuko Sasaki-Hatano; Kenichi Sato; Yoshikuni Mizuno
Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration.
Journal of neurology 2003;250 Suppl 3():III2-10.
2003: Nobutaka Hattori; Yasuko Hatano; Kenichi Sato; Yoshikuni Mizuno
[Juvenile parkinsonism].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(8):1406-13.
2003: Ryosuke Takahashi; Yuzuru Imai; Nobutaka Hattori; Yoshikuni Mizuno
Parkin and endoplasmic reticulum stress.
Annals of the New York Academy of Sciences 2003;991():101-6.
2003: Yasuyuki Okuma; Nobutaka Hattori; Yoshikuni Mizuno
Sensory neuropathy in autosomal recessive juvenile parkinsonism (PARK2).
Parkinsonism & related disorders 2003;9(5):313-4.
2003: Neziha Gouider-Khouja; Abdelmajid Larnaout; Rim Amouri; Sana Sfar; Samir Belal; Christiane Ben Hamida; Mongi Ben Hamida; Nobutaka Hattori; Yoshikuni Mizuno; Faycal Hentati
Autosomal recessive parkinsonism linked to parkin gene in a Tunisian family. Clinical, genetic and pathological study.
Parkinsonism & related disorders 2003;9(5):247-51.
2003: Rivka Inzelberg; Nobutaka Hattori; Puiu Nisipeanu; S Abo Mouch; Sergiu C Blumen; Ralph L Carasso; Yoshikuni Mizuno
Camptocormia, axial dystonia, and parkinsonism: phenotypic heterogeneity of a parkin mutation.
Neurology 2003;60(8):1393-4.
2003: Nina Rawal; Magali Periquet; Ebba Lohmann; Christoph B Lücking; Hélio A G Teive; G Ambrosio; Salmo Raskin; Sarah J Lincoln; Nobutaka Hattori; Joao Guimaraes; Martin Horstink; W Dos Santos Bele; E Brousolle; Alain Destée; Yoshikuni Mizuno; Matthew J Farrer; Jean-François Deleuze; Giuseppe De Michele; Yves Agid; Alexandra Dürr; Alexis Brice
New parkin mutations and atypical phenotypes in families with autosomal recessive parkinsonism.
Neurology 2003;60(8):1378-81.
2003: Tomonori Kobayashi; Hiroto Matsumine; JiaLin Zhang; Yoko Imamichi; Yoshikuni Mizuno; Nobutaka Hattori
Pseudo-autosomal dominant inheritance of PARK2: two families with parkin gene mutations.
Journal of the neurological sciences 2003;207(1-2):11-7.
2003: Hideo Mori; Nobutaka Hattori; Yoshikuni Mizuno
Genotype-phenotype correlation: familial Parkinson disease.
Neuropathology : official journal of the Japanese Society of Neuropathology 2003;23(1):90-4.
2003: Eri Sakata; Yoshiki Yamaguchi; Eiji Kurimoto; Jun Kikuchi; Shigeyuki Yokoyama; Shingo Yamada; Hiroyuki Kawahara; Hideyoshi Yokosawa; Nobutaka Hattori; Yoshikuni Mizuno; Keiji Tanaka; Koichi Kato
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain.
EMBO reports 2003;4(3):301-6.
2003: Tsuyoshi Furuya; Tomoo Namihira; Shigetaka Yamazaki; Hideo Mori; Nobutaka Hattori; Yoshikuni Mizuno
[A 65-year-old woman with progressive loss of vision and visual field defects].
Nō to shinkei = Brain and nerve 2003;55(1):87-96.
2003: Hirokazu Kobayashi; Rejko Krüger; Katerina Markopoulou; Zbigniew K Wszolek; Bruce Chase; Hikari Taka; Reiko Mineki; Kimie Murayama; Olaf Riess; Yoshikuni Mizuno; Nobutaka Hattori
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.
Brain : a journal of neurology 2003;126(Pt 1):32-42.
2002: Nobutaka Hattori
[Parkin gene: its mutations and function].
Rinshō shinkeigaku = Clinical neurology 2002;42(11):1077-81.
2002: Takashi Nomiyama; Yasushi Tanaka; Nobutaka Hattori; K Nishimaki; K Nagasaka; Ryuzo Kawamori; S Ohta
Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients.
Diabetologia 2002;45(11):1577-83.
2002: Masashi Tanaka; Noriyuki Fuku; Takeshi Takeyasu; Li-Jun Guo; Raita Hirose; Miyuki Kurata; Harm-Jan W Borgeld; Yoshiji Yamada; Wakako Maruyama; Yasumichi Arai; Nobuyoshi Hirose; Yoshiharu Oshida; Yuzo Sato; Nobutaka Hattori; Yoshikuni Mizuno; So Iwata; Kunio Yagi
Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease.
Journal of neuroscience research 2002;70(3):347-55.
2002: Masashi Takanashi; Hideo Mori; Kunimasa Arima; Yoshikuni Mizuno; Nobutaka Hattori
Expression patterns of tau mRNA isoforms correlate with susceptible lesions in progressive supranuclear palsy and corticobasal degeneration.
Brain research. Molecular brain research 2002;104(2):210-9.
2002: Dong-Hoon Hyun; MoonHee Lee; Nobutaka Hattori; Shin-Ichiro Kubo; Yoshikuni Mizuno; Barry Halliwell; Peter Jenner
Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome.
The Journal of biological chemistry 2002;277(32):28572-7.
2002: Michael G Schlossmacher; Matthew P Frosch; Wei Ping Gai; Miguel Medina; Nutan Sharma; Lysia Forno; Tomoyo Ochiishi; Hideki Shimura; Ronit Sharon; Nobutaka Hattori; J William Langston; Yoshikuni Mizuno; Bradley T Hyman; Dennis J Selkoe; Kenneth S Kosik
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology 2002;160(5):1655-67.
2002: Nobutaka Hattori; Yoshikuni Mizuno
[Mitochondrial dysfunction in Parkinson's disease].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 4():406-11.
2002: Kenichi Sato; Nobutaka Hattori; Yoshikuni Mizuno
[Malignant migraine].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 4():278-81.
2002: Takashi Nomiyama; Ryuzo Kawamori; Nobutaka Hattori
[Pathogenesis and contribution of mitochondria to diabetes or deafness].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 4():273-7.
2001: A Suzuki; Shin-ichiro Ikebe; Yasuko Komatsuzaki; Masashi Takanashi; Hideo Mori; Nobutaka Hattori; Yoshikuni Mizuno
[A 64-year-old man with parkinsonism as an initial symptom followed by dementia associated with marked abnormal behaviours].
Nō to shinkei = Brain and nerve 2001;53(11):1075-87.
2001: Keiichi Tanaka; T Suzuki; Tsutomu Chiba; H Shimura; Nobutaka Hattori; Yoshikuni Mizuno
Parkin is linked to the ubiquitin pathway.
Journal of molecular medicine (Berlin, Germany) 2001;79(9):482-94.
2001: Yoshikuni Mizuno; Nobutaka Hattori; Hideo Mori; T Suzuki; Keiji Tanaka
Parkin and Parkinson's disease.
Current opinion in neurology 2001;14(4):477-82.
2001: Hideki Shimura; Michael G Schlossmacher; Nobutaka Hattori; Matthew P Frosch; A Trockenbacher; R Schneider; Yoshikuni Mizuno; Kenneth S Kosik; Dennis J Selkoe
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
Science (New York, N.Y.) 2001;293(5528):263-9.
2001: Yumi Shimo-Nakanishi; Takao Urabe; Nobutaka Hattori; Yoshiro Watanabe; T Nagao; Masayuki Yokochi; Makoto Hamamoto; Yoshikuni Mizuno
Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese.
Stroke; a journal of cerebral circulation 2001;32(7):1481-6.
2001: S i Kubo; Toshiaki Kitami; S Noda; Hideki Shimura; Yasuo Uchiyama; Shuichi Asakawa; Shinsei Minoshima; Nobuyoshi Shimizu; Yoshikuni Mizuno; Nobutaka Hattori
Parkin is associated with cellular vesicles.
Journal of neurochemistry 2001;78(1):42-54.
2001: Yuzuru Imai; Mariko Soda; Haruhisa Inoue; Nobutaka Hattori; Yoshikuni Mizuno; Ryosuke Takahashi
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.
Cell 2001;105(7):891-902.
2001: Puiu Nisipeanu; Rivka Inzelberg; S Abo Mouch; Ralph L Carasso; Sergiu C Blumen; J Zhang; H Matsumine; Nobutaka Hattori; Yoshikuni Mizuno
Parkin gene causing benign autosomal recessive juvenile parkinsonism.
Neurology 2001;56(11):1573-5.
2001: M Wang; T Suzuki; Tohru Kitada; Shuichi Asakawa; Shinsei Minoshima; Nobuyoshi Shimizu; Keiji Tanaka; Yoshikuni Mizuno; Nobutaka Hattori
Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain.
Journal of neurochemistry 2001;77(6):1561-8.
2001: B S Jeon; J M Kim; D S Lee; Nobutaka Hattori; Yoshikuni Mizuno
An apparently sporadic case with parkin gene mutation in a Korean woman.
Archives of neurology 2001;58(6):988-9.
2001: Hiroto Matsumine; Nobutaka Hattori; Yoshikuni Mizuno
Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis.
Methods in molecular medicine 2001;62():13-29.
2001: Yoshikuni Mizuno; Nobutaka Hattori; Tohru Kitada; Hiroto Matsumine; Hideo Mori; Hideki Shimura; S i Kubo; Hirokazu Kobayashi; Shuichi Asakawa; Shinsei Minoshima; Nobuyoshi Shimizu
Familial Parkinson's disease. Alpha-synuclein and parkin.
Advances in neurology 2001;86():13-21.
2001: Chin-Song Lu; J C Wu; C H Tsai; Rou-Shayn Chen; Y H Chou; Nobutaka Hattori; H Yoshino; Yoshikuni Mizuno
Clinical and genetic studies on familial parkinsonism: the first report on a parkin gene mutation in a Taiwanese family.
Movement disorders : official journal of the Movement Disorder Society 2001;16(1):164-6.
2000: Nobutaka Hattori; H Shimura; S Kubo; T Suzuki; K Tanaka; Yoshikuni Mizuno
[Autosomal recessive juvenile parkinsonism: its pathogenesis is involved in the ubiquitin-proteasome pathway].
Rinshō shinkeigaku = Clinical neurology 2000;40(12):1293-6.
2000: S Kubo; T Hattori; Masashi Takanashi; Hideo Mori; Y Mizutani; Koichi Suda; Nobutaka Hattori; Yoshikuni Mizuno
[A 57-year-old woman with progressive disturbance of gait and mental deterioration].
Nō to shinkei = Brain and nerve 2000;52(11):1035-44.
2000: Yoshikuni Mizuno; Nobutaka Hattori
[Progress in studies of Parkinson's disease].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2000;89(9):1970-6.
2000: Nobutaka Hattori; Hideki Shimura; S i Kubo; Tohru Kitada; M Wang; Shuichi Asakawa; S Minashima; Nobuyoshi Shimizu; T Suzuki; Keiji Tanaka; Yoshikuni Mizuno
Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease.
Neuropathology : official journal of the Japanese Society of Neuropathology 2000;20 Suppl():S85-90.
2000: Yasuhiro Yamamura; Nobutaka Hattori; H Matsumine; S Kuzuhara; Yoshikuni Mizuno
Autosomal recessive early-onset parkinsonism with diurnal fluctuation: clinicopathologic characteristics and molecular genetic identification.
Brain & development 2000;22 Suppl 1():S87-91.
2000: Hideki Shimura; Nobutaka Hattori; S i Kubo; Yoshikuni Mizuno; Shuichi Asakawa; Shinsei Minoshima; Nobuyoshi Shimizu; K Iwai; Tomoki Chiba; Keiji Tanaka; T Suzuki
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase.
Nature genetics 2000;25(3):302-5.
2000: Tohru Kitada; Shuichi Asakawa; Hiroto Matsumine; Nobutaka Hattori; Hideki Shimura; Shinsei Minoshima; Nobuyoshi Shimizu; Yoshikuni Mizuno
Progress in the clinical and molecular genetics of familial parkinsonism.
Neurogenetics 2000;2(4):207-18.
2000: Nobutaka Hattori; Hideki Shimura; S i Kubo; M Wang; Nobuyoshi Shimizu; Keiji Tanaka; Yoshikuni Mizuno
Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease.
Journal of neural transmission. Supplementum 2000;(60):101-16.
2000: Nobuyoshi Shimizu; Shuichi Asakawa; Shinsei Minoshima; Tohru Kitada; Nobutaka Hattori; Hiroto Matsumine; Masayuki Yokochi; Yasuhiro Yamamura; Yoshikuni Mizuno
PARKIN as a pathogenic gene for autosomal recessive juvenile parkinsonism.
Journal of neural transmission. Supplementum 2000;(58):19-30.
2000: Takao Urabe; Y Yamasaki; Nobutaka Hattori; M Yoshikawa; K Uchida; Yoshikuni Mizuno
Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain.
Neuroscience 2000;100(2):241-50.
1999: Tohru Kitada; Shuichi Asakawa; Hiroto Matsumine; Nobutaka Hattori; Shinsei Minoshima; Nobuyoshi Shimizu; Yoshikuni Mizuno
Positional cloning of the autosomal recessive juvenile parkinsonism (AR-JP) gene and its diversity in deletion mutations.
Parkinsonism & related disorders 1999;5(4):163-8.
1999: Nobutaka Hattori; Yoshikuni Mizuno
[Parkin gene and its function; a key to understand nigral degeneration].
Rinshō shinkeigaku = Clinical neurology 1999;39(12):1259-61.
1999: H Shimura-Miura; Nobutaka Hattori; D Kang; K Miyako; Yusaku Nakabeppu; Yoshikuni Mizuno
Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease.
Annals of neurology 1999;46(6):920-4.
1999: Puiu Nisipeanu; Rivka Inzelberg; Sergiu C Blumen; Ralph L Carasso; Nobutaka Hattori; H Matsumine; Yoshikuni Mizuno
Autosomal-recessive juvenile parkinsonism in a Jewish Yemenite kindred: mutation of Parkin gene.
Neurology 1999;53(7):1602-4.
1999: Nobutaka Hattori; S Sumino; Masashi Takanashi; Hideo Mori; M Wakiya; T Shirai; H Sugita; Yoshikuni Mizuno
[An 80-year-old woman with parkinsonism and progressive dementia].
Nō to shinkei = Brain and nerve 1999;51(6):541-50.
1999: Nobutaka Hattori; Yoshikuni Mizuno
[The Parkin gene and its product in AR-JP].
Nō to shinkei = Brain and nerve 1999;51(6):493-500.
1999: Hideki Shimura; Nobutaka Hattori; S i Kubo; M Yoshikawa; Tohru Kitada; Hiroto Matsumine; Shuichi Asakawa; Shinsei Minoshima; Yasuhiro Yamamura; Nobuyoshi Shimizu; Yoshikuni Mizuno
Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients.
Annals of neurology 1999;45(5):668-72.
1999: M Wang; Nobutaka Hattori; Hiroto Matsumine; Tomonori Kobayashi; Hiroyo Yoshino; A Morioka; Tohru Kitada; Shuichi Asakawa; Shinsei Minoshima; Nobuyoshi Shimizu; Yoshikuni Mizuno
Polymorphism in the parkin gene in sporadic Parkinson's disease.
Annals of neurology 1999;45(5):655-8.
1999: Yoshikuni Mizuno; Nobutaka Hattori; Hideo Mori
Genetics of Parkinson's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1999;53(3):109-16.
1999: A Yoritaka; Y Nakagawa-Hattori; Nobutaka Hattori; A Kitahara; Yoshikuni Mizuno
A large Japanese family with Machado-Joseph disease: clinical and genetic analysis.
Acta neurologica Scandinavica 1999;99(4):241-4.
1999: Yoshikuni Mizuno; S Shimoda-Matsubayashi; Hiroto Matsumine; N Morikawa; Nobutaka Hattori; Tomoyoshi Kondo
Genetic and environmental factors in the pathogenesis of Parkinson's disease.
Advances in neurology 1999;80():171-9.
1998: Nobutaka Hattori; Tohru Kitada; Hiroto Matsumine; Shuichi Asakawa; Yasuhiro Yamamura; Hiroyo Yoshino; Tomonori Kobayashi; Masayuki Yokochi; M Wang; A Yoritaka; Tomoyoshi Kondo; S Kuzuhara; S Nakamura; Nobuyoshi Shimizu; Yoshikuni Mizuno
Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the Parkin gene in affected individuals.
Annals of neurology 1998;44(6):935-41.
1998: Yoshikuni Mizuno; Hiroyo Yoshino; Shin-ichiro Ikebe; Nobutaka Hattori; Tomonori Kobayashi; S Shimoda-Matsubayashi; Hiroto Matsumine; Tomoyoshi Kondo
Mitochondrial dysfunction in Parkinson's disease.
Annals of neurology 1998;44(3 Suppl 1):S99-109.
1998: Yoshikuni Mizuno; Nobutaka Hattori; Hiroto Matsumine
Neurochemical and neurogenetic correlates of Parkinson's disease.
Journal of neurochemistry 1998;71(3):893-902.
1998: Nobutaka Hattori; Hiroto Matsumine; Shuichi Asakawa; Tohru Kitada; Hiroyo Yoshino; B Elibol; A J Brookes; Yasuhiro Yamamura; Tomonori Kobayashi; M Wang; A Yoritaka; Shinsei Minoshima; Nobuyoshi Shimizu; Yoshikuni Mizuno
Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene.
Biochemical and biophysical research communications 1998;249(3):754-8.
1998: Yasuyuki Okuma; Nobutaka Hattori; Bunsei Nobukawa; Hideo Mori; Koichi Suda; Hideki Takubo; Yoshikuni Mizuno
[A 74-year-old woman with parkinsonism and dementia who died four years after the onset].
Nō to shinkei = Brain and nerve 1998;50(7):671-82.
1998: T Urabe; Nobutaka Hattori; M Yoshikawa; H Yoshino; K Uchida; Yoshikuni Mizuno
Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat brain following transient focal ischemia.
Neuroscience letters 1998;247(2-3):159-62.
1998: Hideki Takubo; Nobutaka Hattori; S Irie; Y Mizutani; Hideo Mori; Koichi Suda; Tomoyoshi Kondo; K Oshimi; Yoshikuni Mizuno
[A 45-year-old man with peripheral monocytosis and right hemiparesis].
Nō to shinkei = Brain and nerve 1998;50(5):481-9.
1998: Tohru Kitada; Shuichi Asakawa; Nobutaka Hattori; Hiroto Matsumine; Yasuhiro Yamamura; Shinsei Minoshima; Masayuki Yokochi; Yoshikuni Mizuno; Nobuyoshi Shimizu
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
Nature 1998;392(6676):605-8.
1998: Hiroto Matsumine; Yasuhiro Yamamura; Nobutaka Hattori; Tomonori Kobayashi; Tohru Kitada; A Yoritaka; Yoshikuni Mizuno
A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2).
Genomics 1998;49(1):143-6.
1998: Nobutaka Hattori; Hiroyo Yoshino; M Tanaka; H Suzuki; Yoshikuni Mizuno
Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease.
Genomics 1998;49(1):52-8.
1998: S Sato; Nobutaka Hattori; Hiroto Matsumine; H Imai; Yoshikuni Mizuno
[A patient with focal bi-parietal atrophy presenting motor clumsiness and cortical sensory loss].
Rinshō shinkeigaku = Clinical neurology 1998;38(3):246-51.
1997: H Yoshino; Nobutaka Hattori; T Urabe; K Uchida; M Tanaka; Yoshikuni Mizuno
Postischemic accumulation of lipid peroxidation products in the rat brain: immunohistochemical detection of 4-hydroxy-2-nonenal modified proteins.
Brain research 1997;767(1):81-6.
1997: A Yoritaka; Nobutaka Hattori; Hideo Mori; K Kato; Yoshikuni Mizuno
An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease.
Journal of the neurological sciences 1997;148(2):181-6.
1997: A Yoritaka; Nobutaka Hattori; Hiroyo Yoshino; Yoshikuni Mizuno
Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(11-12):1313-7.
1996: Nobutaka Hattori; K Goto; Hideo Mori; I Tominaga; T Kondo; Yoshikuni Mizuno
[A 46-year-old man with right-side dominant parkinsonism, who suffered a sudden death].
Nō to shinkei = Brain and nerve 1996;48(11):1059-67.
1996: N Nakamura; Nobutaka Hattori; M Tanaka; Yoshikuni Mizuno
Specific detection of deleted mitochondrial DNA by in situ hybridization using a chimera probe.
Biochimica et biophysica acta 1996;1308(3):215-21.
1996: T Urabe; Nobutaka Hattori; S Nagamatsu; H Sawa; Yoshikuni Mizuno
Expression of glucose transporters in rat brain following transient focal ischemic injury.
Journal of neurochemistry 1996;67(1):265-71.
1996: A Yoritaka; Nobutaka Hattori; K Uchida; M Tanaka; E R Stadtman; Yoshikuni Mizuno
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2696-701.
1995: Nobutaka Hattori; H Suzuki; Y Wang; Shinsei Minoshima; Nobuyoshi Shimizu; Hiroyo Yoshino; R Kurashima; M Tanaka; T Ozawa; Yoshikuni Mizuno
Structural organization and chromosomal localization of the human nuclear gene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial respiratory chain.
Biochemical and biophysical research communications 1995;216(3):771-7.
1995: Nobutaka Hattori; K Sugano; M Wakiya; Hideo Mori; T Shirai; Yoshikuni Mizuno
[A 56-year-old woman with parkinsonism and dementia with the age of onset at 41 years].
Nō to shinkei = Brain and nerve 1995;47(9):911-9.
1995: Yoshikuni Mizuno; S Ikebe; Nobutaka Hattori; Y Nakagawa-Hattori; Hideki Mochizuki; M Tanaka; T Ozawa
Role of mitochondria in the etiology and pathogenesis of Parkinson's disease.
Biochimica et biophysica acta 1995;1271(1):265-74.
1994: Yoshikuni Mizuno; S Ikebe; Nobutaka Hattori; Hideki Mochizuki; Y Nakagawa-Hattori; T Kondo
Studies on the pathogenesis of Parkinson's disease in Japan.
Archives of gerontology and geriatrics 1994;19(2):105-21.
1994: Hideki Mochizuki; H Imai; K Endo; K Yokomizo; Y Murata; Nobutaka Hattori; Yoshikuni Mizuno
Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys.
Neuroscience letters 1994;168(1-2):251-3.
1994: Yoshikuni Mizuno; S Matuda; Hiroyo Yoshino; Hideo Mori; Nobutaka Hattori; S Ikebe
An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease.
Annals of neurology 1994;35(2):204-10.
1993: Yoshikuni Mizuno; S Ikebe; Nobutaka Hattori; T Kondo; M Tanaka; T Ozawa
Mitochondrial energy crisis in Parkinson's disease.
Advances in neurology 1993;60():282-7.
1993: Nobutaka Hattori; S Ikebe; M Tanaka; T Ozawa; Yoshikuni Mizuno
Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.
Advances in neurology 1993;60():292-6.
1991: Nobutaka Hattori; M Tanaka; T Ozawa; Yoshikuni Mizuno
Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.
Annals of neurology 1991;30(4):563-71.
1990: S Shimoda-Matsubayashi; Y Kuru; H Sumie; T Ito; Nobutaka Hattori; Y Okuma; Yoshikuni Mizuno
MRI findings in the mild type of mucopolysaccharidosis II (Hunter's syndrome).
Neuroradiology 1990;32(4):328-30.