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Tomoichiro Asano

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Yuichiro Otani; Hideyuki Sakoda; Shin-Ichiro Takahashi; Yoshihiro Tsuchiya; Midori Fujishiro; Toshiaki Fukushima; Hideaki Kamata; Hideki Katagiri; Akifumi Kushiyama; Yusuke Nakatsu; Fusanori Nishimura; Haruya Ohno; Hirofumi Okubo; Tomoichiro Asano
Integrator complex plays an essential role in adipose differentiation.
Tokuo Saito; Tatsuo Shimosawa; Kenji Uno; Tetsuya Yamada; Takehide Ogihara; Yoshitomo Oka; Tomoichiro Asano; Toshiro Fujita; Junhong Gao; Yutaka Hasegawa; Junta Imai; Yasushi Ishigaki; Keizo Kaneko; Hideki Katagiri
Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation.
Toshiaki Fukushima; Fumihiko Hakuno; Shiro Minami; Yusaku Nakamura; Takashi Shibano; Tomoichiro Asano; Kazuhiro Chida; Daisuke Yamanaka; Shin-Ichiro Takahashi
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

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All Publications

2013: Yuichiro Otani; Hideyuki Sakoda; Shin-Ichiro Takahashi; Yoshihiro Tsuchiya; Midori Fujishiro; Toshiaki Fukushima; Hideaki Kamata; Hideki Katagiri; Akifumi Kushiyama; Yusuke Nakatsu; Fusanori Nishimura; Haruya Ohno; Hirofumi Okubo; Tomoichiro Asano
Integrator complex plays an essential role in adipose differentiation.
Biochemical and biophysical research communications 2013;434(2):197-202.
2013: Tokuo Saito; Tatsuo Shimosawa; Kenji Uno; Tetsuya Yamada; Takehide Ogihara; Yoshitomo Oka; Tomoichiro Asano; Toshiro Fujita; Junhong Gao; Yutaka Hasegawa; Junta Imai; Yasushi Ishigaki; Keizo Kaneko; Hideki Katagiri
Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation.
Cardiovascular research 2013;97(1):106-14.
2012: Toshiaki Fukushima; Fumihiko Hakuno; Shiro Minami; Yusaku Nakamura; Takashi Shibano; Tomoichiro Asano; Kazuhiro Chida; Daisuke Yamanaka; Shin-Ichiro Takahashi
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
The Journal of biological chemistry 2012;287(35):29713-21.
2012: Hidehito Yoshihara; Keiji Tanaka; Minoru Yoshida; Tomoichiro Asano; Kazuhiro Chida; Toshiaki Fukushima; Leonard Girnita; Fumihiko Hakuno; Shun-ichiro Iemura; Akihiro Ito; Tohru Natsume; Yasushi Saeki; Shin-Ichiro Takahashi
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Biochemical and biophysical research communications 2012;423(1):122-7.
2012: Yutaka Hasegawa; Junta Imai; Yasushi Ishigaki; Keizo Kaneko; Takehide Ogihara; Yoshitomo Oka; Tokuo Saito; Tatsuo Shimosawa; Kenji Uno; Tetsuya Yamada; Tomoichiro Asano; Toshiro Fujita; Junhong Gao; Hideki Katagiri
Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans.
Circulation 2012;125(9):1122-33.
2011: Toshiaki Fukushima; Fumihiko Hakuno; Akihiro Ito; Shinji Nagata; Hiroshi Okajima; Miyako Ariga; Tomoichiro Asano; Kazuhiro Chida; Daisuke Yamanaka; Minoru Yoshida; Shin-Ichiro Takahashi
HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells.
Molecular and cellular endocrinology 2011;344(1-2):81-9.
2011: Kazuo Tonami; Yukiko Kurihara; Satoshi Arima; Koichi Nishiyama; Yasunobu Uchijima; Tomoichiro Asano; Hiroyuki Sorimachi; Hiroki Kurihara
Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1.
Journal of cell science 2011;124(Pt 8):1214-23.
2011: Toshiaki Fukushima; Toshiya Arai; Miyako Ariga-Nedachi; Hiroshi Okajima; Yuko Ooi; Yumi Iijima; Meri Sone; Yoshitake Cho; Yasutoshi Ando; Kohei Kasahara; Atsufumi Ozoe; Hidehito Yoshihara; Kazuhiro Chida; Shigeru Okada; John J Kopchick; Tomoichiro Asano; Fumihiko Hakuno; Shin-Ichiro Takahashi
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.
Biochemical and biophysical research communications 2011;404(3):767-73.
2011: Haruya Ohno; Tomoichiro Asano
[Skeletal muscle insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 1():176-9.
2010: Hideaki Kamata; Yoshihiro Tsuchiya; Tomoichiro Asano
IκBβ is a positive and negative regulator of NF-κB activity during inflammation.
Cell research 2010;20(11):1178-80.
2010: Yoshihiro Tsuchiya; Tomoichiro Asano; Keiko Nakayama; Tomohisa Kato; Michael Karin; Hideaki Kamata
Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.
Molecular cell 2010;39(4):570-82.
2010: Michihiro Shibata; Fumihiko Hakuno; Daisuke Yamanaka; Hiroshi Okajima; Toshiaki Fukushima; Takashi Hasegawa; Tomomi Ogata; Yuka Toyoshima; Kazuhiro Chida; Kumi Kimura; Hideyuki Sakoda; A Takenaka; Tomoichiro Asano; Shin-Ichiro Takahashi
Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.
The Journal of biological chemistry 2010;285(27):20915-25.
2010: Tomohiro Kabuta; Fumihiko Hakuno; Yoshitake Cho; Daisuke Yamanaka; Kazuhiro Chida; Tomoichiro Asano; Keiji Wada; Shin-Ichiro Takahashi
Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity.
Biochemical and biophysical research communications 2010;394(3):697-702.
2010: Victoria Rotter Sopasakis; Pixu Liu; Ryo Suzuki; Tatsuya Kondo; Jonathon Winnay; Thien T Tran; Tomoichiro Asano; Graham Smyth; Mini P Sajan; Robert V Farese; C Ronald Kahn; Jean J Zhao
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Cell metabolism 2010;11(3):220-30.
2010: Xinglong Cui; Akifumi Kushiyama; Masayasu Yoneda; Yusuke Nakatsu; Ying Guo; Jun Zhang; Hiraku Ono; Machi Kanna; Hideyuki Sakoda; Hiraku Ono; Takako Kikuchi; Midori Fujishiro; Masashi Shiomi; Hideaki Kamata; Hiroki Kurihara; Masatoshi Kikuchi; Shoji Kawazu; Fusanori Nishimura; Tomoichiro Asano
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.
Diabetes research and clinical practice 2010;87(1):57-63.
2009: Norio Ishii; Takeshi Matsumura; Hiroyuki Kinoshita; Hiroyuki Motoshima; Kanou Kojima; Atsuyuki Tsutsumi; Shuji Kawasaki; Miyuki Yano; Takafumi Senokuchi; Tomoichiro Asano; Takeshi Nishikawa; Eiichi Araki
Activation of AMP-activated protein kinase suppresses oxidized low-density lipoprotein-induced macrophage proliferation.
The Journal of biological chemistry 2009;284(50):34561-9.
2009: Naoko Sasaki-Suzuki; K i Arai; Tomomi Ogata; Kouhei Kasahara; Hideyuki Sakoda; Kazuhiro Chida; Tomoichiro Asano; Jeffrey Pessin; Fumihiko Hakuno; Shin-Ichiro Takahashi
Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway.
The Journal of biological chemistry 2009;284(10):6061-70.
2008: Frank Kuhnert; Michael R Mancuso; Jessica Hampton; Kryn Stankunas; Tomoichiro Asano; Chang-Zheng Chen; Calvin J Kuo
Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126.
Development (Cambridge, England) 2008;135(24):3989-93.
2008: M Egawa; H Kamata; Akifumi Kushiyama; H Sakoda; Midori Fujishiro; N Horike; Masayasu Yoneda; Yusuke Nakatsu; Guo Ying; Zhang Jun; Y Tsuchiya; K Takata; H Kurihara; Tomoichiro Asano
Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells.
Placenta 2008;29(12):1003-8.
2008: Junta Imai; Hideki Katagiri; Tetsuya Yamada; Yasushi Ishigaki; Toshinobu Suzuki; Hirohito Kudo; Kenji Uno; Yutaka Hasegawa; Junhong Gao; Keizo Kaneko; Hisamitsu Ishihara; Akira Niijima; Masamitsu Nakazato; Tomoichiro Asano; Yasuhiko Minokoshi; Yoshitomo Oka
Regulation of pancreatic beta cell mass by neuronal signals from the liver.
Science (New York, N.Y.) 2008;322(5905):1250-4.
2008: Hiraku Ono; Alessandro Pocai; Yuhua Wang; Hideyuki Sakoda; Tomoichiro Asano; Jonathan M Backer; Gary J Schwartz; Luciano Rossetti
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats.
The Journal of clinical investigation 2008;118(8):2959-68.
2008: Yuko Koketsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Yasushi Fukushima; Hiraku Ono; Motonobu Anai; Takako Kikuchi; Takeshi Fukuda; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.
American journal of physiology. Endocrinology and metabolism 2008;294(4):E719-25.
2008: Ryosuke Makita; Yasunobu Uchijima; Koichi Nishiyama; Tomokazu Amano; Qin Chen; Takumi Takeuchi; Akihisa Mitani; Takahide Nagase; Yutaka Yatomi; Hiroyuki Aburatani; Osamu Nakagawa; Erin V Small; Patricia Cobo-Stark; Peter Igarashi; Masao Murakami; Junji Tominaga; Takahiro Sato; Tomoichiro Asano; Yukiko Kurihara; Hiroki Kurihara
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.
American journal of physiology. Renal physiology 2008;294(3):F542-53.
2008: Yuichi Ikegami; Kouichi Inukai; Takuya Awata; Tomoichiro Asano; Shigehiro Katayama
SH3 domain of the phosphatidylinositol 3-kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1.
Biochemical and biophysical research communications 2008;365(3):433-8.
2008: Yukiko Kurihara; Yumiko Kawamura; Yasunobu Uchijima; Tomokazu Amamo; Hiroshi Kobayashi; Tomoichiro Asano; Hiroki Kurihara
Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1.
Developmental biology 2008;313(1):335-46.
2008: Junko Fujio; Akifumi Kushiyama; Hideyuki Sakoda; Midori Fujishiro; Takehide Ogihara; Yasushi Fukushima; Motonobu Anai; Nanao Horike; Hideaki Kamata; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Regulation of gut-derived resistin-like molecule beta expression by nutrients.
Diabetes research and clinical practice 2008;79(1):2-10.
2007: Hiraku Ono; Hideyuki Sakoda; Midori Fujishiro; Motonobu Anai; Akifumi Kushiyama; Yasushi Fukushima; Hideki Katagiri; Takehide Ogihara; Yoshitomo Oka; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.
American journal of physiology. Cell physiology 2007;293(5):C1576-85.
2007: Tomoichiro Asano; Midori Fujishiro; Akifumi Kushiyama; Yusuke Nakatsu; Masayasu Yoneda; Hideaki Kamata; Hideyuki Sakoda
Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions.
Biological & pharmaceutical bulletin 2007;30(9):1610-6.
2007: Hiromitsu Takagi; Yutaka Matsui; Shinichi Hirotani; Hideyuki Sakoda; Tomoichiro Asano; Junichi Sadoshima
AMPK mediates autophagy during myocardial ischemia in vivo.
Autophagy 2007;3(4):405-7.
2007: Koichi Nishiyama; Kentaro Takaji; Yasunobu Uchijima; Yukiko Kurihara; Tomoichiro Asano; Michihiro Yoshimura; Hisao Ogawa; Hiroki Kurihara
Protein kinase A-regulated nucleocytoplasmic shuttling of Id1 during angiogenesis.
The Journal of biological chemistry 2007;282(23):17200-9.
2007: Yasuhiro Yamaguchi; Takashi Nagase; Tetsuji Tomita; Kyoko Nakamura; Shigetomo Fukuhara; Tomokazu Amano; Hiroshi Yamamoto; Yukie Ide; Misao Suzuki; Shinji Teramoto; Tomoichiro Asano; Kenji Kangawa; Naomi Nakagata; Yasuyoshi Ouchi; Hiroki Kurihara
Beta-defensin overexpression induces progressive muscle degeneration in mice.
American journal of physiology. Cell physiology 2007;292(6):C2141-9.
2007: Cullen M Taniguchi; José O Aleman; Kohjiro Ueki; Ji Luo; Tomoichiro Asano; Hideaki Kaneto; Gregory Stephanopoulos; Lewis C Cantley; C Ronald Kahn
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2007: Kazuo Tonami; Yukiko Kurihara; Hiroyuki Aburatani; Yasunobu Uchijima; Tomoichiro Asano; Hiroki Kurihara
Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.
Molecular and cellular biology 2007;27(7):2548-61.
2007: Yutaka Matsui; Hiromitsu Takagi; Xueping Qu; Maha Abdellatif; Hideyuki Sakoda; Tomoichiro Asano; Beth Levine; Junichi Sadoshima
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.
Circulation research 2007;100(6):914-22.
2006: Tomoichiro Asano
[Muscular insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():139-44.
2006: Tomoichiro Asano; Hideyuki Sakosda; Midori Fujishiro; Motonobu Anai; Akifumi Kushiyama; Nanao Horike; Hideaki Kamata; Takehide Ogihara; Hiroki Kurihara; Yasunobu Uchijima
Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance.
Current diabetes reviews 2006;2(4):449-54.
2006: Lindsay C Spender; Walter Lucchesi; Gustavo Bodelon; Antonio Bilancio; Claudio Elgueta Karstegl; Tomoichiro Asano; Oliver Dittrich-Breiholz; Michael Kracht; Bart Vanhaesebroeck; Paul J Farrell
Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
The Journal of general virology 2006;87(Pt 10):2859-67.
2006: Amelia Y I Viana; Hideyuki Sakoda; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Akifumi Kushiyama; Yasushi Fukushima; Yuzo Sato; Yoshiharu Oshida; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.
Diabetes research and clinical practice 2006;73(2):135-42.
2006: Kenji Uno; Hideki Katagiri; Tetsuya Yamada; Yasushi Ishigaki; Takehide Ogihara; Junta Imai; Yutaka Hasegawa; Junhong Gao; Keizo Kaneko; Hiroko Iwasaki; Hisamitsu Ishihara; Hironobu Sasano; Kouichi Inukai; Hiroyuki Mizuguchi; Tomoichiro Asano; Masakazu Shiota; Masamitsu Nakazato; Yoshitomo Oka
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
Science (New York, N.Y.) 2006;312(5780):1656-9.
2006: Cullen M Taniguchi; Tatsuya Kondo; Mini P Sajan; Ji Luo; Roderick Bronson; Tomoichiro Asano; Robert Farese; Lewis C Cantley; C Ronald Kahn
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
Cell metabolism 2006;3(5):343-53.
2006: Tetsuya Yamada; Hideki Katagiri; Yasushi Ishigaki; Takehide Ogihara; Junta Imai; Kenji Uno; Yutaka Hasegawa; Junhong Gao; Hisamitsu Ishihara; Akira Niijima; Hiroyuki Mano; Hiroyuki Aburatani; Tomoichiro Asano; Yoshitomo Oka
Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation.
Cell metabolism 2006;3(3):223-9.
2006: Masao Murakami; Junji Tominaga; Ryosuke Makita; Yasunobu Uchijima; Yukiko Kurihara; Osamu Nakagawa; Tomoichiro Asano; Hiroki Kurihara
Transcriptional activity of Pax3 is co-activated by TAZ.
Biochemical and biophysical research communications 2006;339(2):533-9.
2005: Akifumi Kushiyama; Nobuhiro Shojima; Takehide Ogihara; Kouichi Inukai; Hideyuki Sakoda; Midori Fujishiro; Yasushi Fukushima; Motonobu Anai; Hiraku Ono; Nanao Horike; Amelia Y I Viana; Yasunobu Uchijima; Koichi Nishiyama; Tatsuo Shimosawa; Toshiro Fujita; Hideki Katagiri; Yoshitomo Oka; Hiroki Kurihara; Tomoichiro Asano
Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.
The Journal of biological chemistry 2005;280(51):42016-25.
2005: Motoyuki Igata; Hiroyuki Motoshima; Kaku Tsuruzoe; Kanou Kojima; Takeshi Matsumura; Tatsuya Kondo; Tetsuya Taguchi; Kazuhiko Nakamaru; Miyuki Yano; Daisuke Kukidome; Kazuya Matsumoto; Tetsushi Toyonaga; Tomoichiro Asano; Takeshi Nishikawa; Eiichi Araki
Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression.
Circulation research 2005;97(8):837-44.
2005: Hideyuki Sakoda; Midori Fujishiro; Junko Fujio; Nobuhiro Shojima; Takehide Ogihara; Akifumi Kushiyama; Yasushi Fukushima; Motonobu Anai; Hiraku Ono; Masatoshi Kikuchi; Nanao Horike; Amelia Y I Viana; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E474-81.
2005: Motonobu Anai; Nobuhiro Shojima; Hideki Katagiri; Takehide Ogihara; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Yasushi Fukushima; Nanao Horike; Amelia Y I Viana; Masatoshi Kikuchi; Noriko Noguchi; Shinichiro Takahashi; Kuniaki Takata; Yoshitomo Oka; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
The Journal of biological chemistry 2005;280(18):18525-35.
2005: Nobuhiro Shojima; Toshio Ogihara; Kouichi Inukai; Midori Fujishiro; Hideyuki Sakoda; Akifumi Kushiyama; Hideki Katagiri; Motonobu Anai; Hiraku Ono; Yasushi Fukushima; Nanao Horike; Amelia Y I Viana; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.
Diabetologia 2005;48(5):984-92.
2005: Kathrine Abell; Antonio Bilancio; Richard W E Clarkson; Paul G Tiffen; Anton I Altaparmakov; Thomas G Burdon; Tomoichiro Asano; Bart Vanhaesebroeck; Christine J Watson
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition.
Nature cell biology 2005;7(4):392-8.
2005: Nanao Horike; Tomoichiro Asano
[Disorder of glucose metabolism in skeletal muscle].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():136-40.
2005: Yasushi Ishigaki; Hideki Katagiri; Tetsuya Yamada; Takehide Ogihara; Junta Imai; Kenji Uno; Yutaka Hasegawa; Junhong Gao; Hisamitsu Ishihara; Tooru Shimosegawa; Hideyuki Sakoda; Tomoichiro Asano; Yoshitomo Oka
Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.
Diabetes 2005;54(2):322-32.
2005: Velen L Nelson-DeGrave; Jessica K Wickenheisser; Karen L Hendricks; Tomoichiro Asano; Midori Fujishiro; Richard S Legro; Scot R Kimball; Jerome F Strauss; Jan M McAllister
Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):379-90.
2005: Junta Imai; Hideki Katagiri; Tetsuya Yamada; Yasushi Ishigaki; Takehide Ogihara; Kenji Uno; Yutaka Hasegawa; Junhong Gao; Hisamitsu Ishihara; Hironobu Sasano; Hiroyuki Mizuguchi; Tomoichiro Asano; Yoshitomo Oka
Constitutively active PDX1 induced efficient insulin production in adult murine liver.
Biochemical and biophysical research communications 2005;326(2):402-9.
2004: Takashi Okamoto; Kazuhiko Namikawa; Tomoichiro Asano; Kunio Takaoka; Hiroshi Kiyama
Differential regulation of the regulatory subunits for phosphatidylinositol 3-kinase in response to motor nerve injury.
Brain research. Molecular brain research 2004;131(1-2):119-25.
2004: Tomoichiro Asano; Yasushi Saito; Masanobu Kawakami; Nobuhiro Yamada; Hisakuni Sekino; Setsuo Hasegawa
Erythrocytic sorbitol contents in diabetic patients correlate with blood aldose reductase protein contents and plasma glucose levels, and are normalized by the potent aldose reductase inhibitor fidarestat (SNK-860).
Journal of diabetes and its complications 2004;18(6):336-42.
2004: Yasushi Fukushima; Toshimitsu Matsui; Toshihito Saitoh; Masao Ichinose; Keisuke Tateishi; Takayuki Shindo; Midori Fujishiro; Hideyuki Sakoda; Nobuhiro Shojima; Akifumi Kushiyama; Satoru Fukuda; Motonobu Anai; Hiraku Ono; Masashi Oka; Yasuhito Shimizu; Hiroki Kurihara; Ryozo Nagai; Takashi Ishikawa; Tomoichiro Asano; Masao Omata
Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.
European journal of pharmacology 2004;502(3):243-52.
2004: Tomoichiro Asano; Takehide Ogihara; Hideki Katagiri; Hideyuki Sakoda; Hiraku Ono; Midori Fujishiro; Motonobu Anai; Hiroki Kurihara; Yasunobu Uchijima
Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs.
Current medicinal chemistry 2004;11(20):2717-24.
2004: Guangqun Xing; Tatsuo Shimosawa; Takehide Ogihara; Hiromitsu Matsui; Kanami Itakura; Xu Qingyou; Tomoichiro Asano; Katsuyuki Ando; Toshiro Fujita
Angiotensin II-induced insulin resistance is enhanced in adrenomedullin-deficient mice.
Endocrinology 2004;145(8):3647-51.
2004: Soichi Obara; Masanori Nakata; Hideo Takeshima; Hideki Katagiri; Tomoichiro Asano; Yoshitomo Oka; Ikuro Maruyama; Jun-ichi Kuratsu
Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398.
Cancer letters 2004;208(1):115-22.
2004: Toshio Ogihara; Tomoichiro Asano; Hideki Katagiri; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Midori Fujishiro; Akifumi Kushiyama; Yasushi Fukushima; Masatoshi Kikuchi; Noriko Noguchi; Hiroyuki Aburatani; Yukiko Gotoh; Issei Komuro; Toshiro Fujita
Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Diabetologia 2004;47(5):794-805.
2003: Hiraku Ono; Hitoshi Shimano; Hideki Katagiri; Naoya Yahagi; Hideyuki Sakoda; Yukiko Onishi; Motonobu Anai; Takehide Ogihara; Midori Fujishiro; Amelia Y I Viana; Yasushi Fukushima; Miho Abe; Nobuhiro Shojima; Masatoshi Kikuchi; Nobuhiro Yamada; Yoshitomo Oka; Tomoichiro Asano
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Diabetes 2003;52(12):2905-13.
2003: Kohjiro Ueki; David A Fruman; Claudine M Yballe; Mathias Fasshauer; Johannes Klein; Tomoichiro Asano; Lewis C Cantley; C Ronald Kahn
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
The Journal of biological chemistry 2003;278(48):48453-66.
2003: Aiichiro Yamamoto; Akira Fukuda; Hiroaki Seto; Tsuyoshi Miyazaki; Yuho Kadono; Yasuhiro Sawada; Ichiro Nakamura; Hideki Katagiri; Tomoichiro Asano; Yoshiya Tanaka; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts.
Arthritis and rheumatism 2003;48(9):2682-92.
2003: Hideyuki Sakoda; Yukiko Gotoh; Hideki Katagiri; Mineo Kurokawa; Hiraku Ono; Yukiko Onishi; Motonobu Anai; Takehide Ogihara; Midori Fujishiro; Yasushi Fukushima; Miho Abe; Nobuhiro Shojima; Masatoshi Kikuchi; Yoshitomo Oka; Hisamaru Hirai; Tomoichiro Asano
Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.
The Journal of biological chemistry 2003;278(28):25802-7.
2003: Takehide Ogihara; Tomoichiro Asano
[Hemodynamic factors].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(7):1099-104.
2003: Takehide Ogihara; Tomoichiro Asano; Toshiro Fujita
Contribution of salt intake to insulin resistance associated with hypertension.
Life sciences 2003;73(5):509-23.
2003: Nanao Horike; Hiroshi Takemori; Yoshiko Katoh; Junko Doi; Li Min; Tomoichiro Asano; Xiao Jian Sun; Hiroyasu Yamamoto; Soji Kasayama; Masaaki Muraoka; Yasuki Nonaka; Mitsuhiro Okamoto
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
The Journal of biological chemistry 2003;278(20):18440-7.
2003: Yasushi Fukushima; Takayuki Shindo; Motonobu Anai; Toshihito Saitoh; Yuhui Wang; Midori Fujishiro; Yoshio Ohashi; Takehide Ogihara; Kouichi Inukai; Hiraku Ono; Hideyuki Sakoda; Yukiko Kurihara; Miho Honda; Nobuhiro Shojima; Harumi Fukushima; Yukiko Haraikawa-Onishi; Hideki Katagiri; Yasuhito Shimizu; Masao Ichinose; Takashi Ishikawa; Masao Omata; Ryozo Nagai; Hiroki Kurihara; Tomoichiro Asano
Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.
European journal of pharmacology 2003;468(1):47-58.
2003: Tatsuo Shimosawa; Takehide Ogihara; Hiromitsu Matsui; Tomoichiro Asano; Katsuyuki Ando; Toshiro Fujita
Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress.
Hypertension 2003;41(5):1080-5.
2003: Yukiko Onishi; Miho Honda; Takehide Ogihara; Hideyuki Sakoda; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Nobuhiro Shojima; Yasushi Fukushima; Kouichi Inukai; Hideki Katagiri; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation.
Biochemical and biophysical research communications 2003;303(3):788-94.
2003: Midori Fujishiro; Takehide Ogihara; Katsunori Tsukuda; Nobuhiro Shojima; Yasushi Fukushima; Satoshi Kimura; Yoshitomo Oka; Tomoichiro Asano
A case showing an association between type 1 diabetes mellitus and Kabuki syndrome.
Diabetes research and clinical practice 2003;60(1):25-31.
2003: Harumi Suzuki; Satoshi Matsuda; Yasuo Terauchi; Mari Fujiwara; Toshiaki Ohteki; Tomoichiro Asano; timothy wayne behrens; Taku Kouro; Kiyoshi Takatsu; Takashi Kadowaki; Shigeo Koyasu
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.
Nature immunology 2003;4(3):280-6.
2003: Midori Fujishiro; Yukiko Gotoh; Hideki Katagiri; Hideyuki Sakoda; Takehide Ogihara; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Miho Abe; Nobuhiro Shojima; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2003;17(3):487-97.
2003: Yasushi Fukushima; Takashi Ishikawa; Toshihito Saitoh; Keisuke Tateishi; Takehide Ogihara; Midori Fujishiro; Nobuhiro Shojima; Miho Honda; Akifumi Kushiyama; Motonobu Anai; Hideyuki Sakoda; Hiraku Ono; Yukiko Onishi; Hiroko Otsuka; Hideki Katagiri; Ryozo Nagai; Masao Omata; Tomoichiro Asano
Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells.
Digestion 2003;68(2-3):145-52.
2002: Miho Honda; Seiji Fukumoto; Toshiro Fujita; Yoshitomo Oka; Tomoichiro Asano
Association of HLA-CW3 with type 1 diabetes mellitus and idiopathic hypoparathyroidism in the Japanese.
Endocrine journal 2002;49(6):653-4.
2002: Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Yuko Chiba; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Hideki Katagiri; Yasushi Fukushima; Masatoshi Kikuchi; Noriko Noguchi; Hiroyuki Aburatani; Issei Komuro; Toshiro Fujita
Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.
Hypertension 2002;40(6):872-9.
2002: Haiyan Song; Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; Hitoshi Shimano; Nobuhiro Yamada; Yoshitomo Oka; Tomoichiro Asano
Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.
Biochemical and biophysical research communications 2002;299(2):291-8.
2002: Miho Honda; Tomoichiro Asano
[Indices of body weight and body fat distribution].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():685-90.
2002: Katsunori Tsukuda; Tomoichiro Asano
[Importance of dietary fat composition in dietary treatment of diabetes mellitus].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():232-7.
2002: Taro Fukao; Masanobu Tanabe; Yasuo Terauchi; Takayuki Ota; Satoshi Matsuda; Tomoichiro Asano; Takashi Kadowaki; Tsutomu Takeuchi; Shigeo Koyasu
PI3K-mediated negative feedback regulation of IL-12 production in DCs.
Nature immunology 2002;3(9):875-81.
2002: Masatoshi Tsuru; Hideki Katagiri; Tomoichiro Asano; Tetsuya Yamada; Shigeo Ohno; Takehide Ogihara; Yoshitomo Oka
Role of PKC isoforms in glucose transport in 3T3-L1 adipocytes: insignificance of atypical PKC.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E338-45.
2002: Takehide Ogihara; Tomoichiro Asano
[Glucose transporter (GLUT4)].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():577-82.
2002: Tomoichiro Asano
[Signal transduction from the insulin receptor].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():240-5.
2002: Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Toshiro Fujita
High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.
Hypertension 2002;40(1):83-9.
2002: Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
Diabetes 2002;51(6):1737-44.
2002: Tetsuya Yamada; Hideki Katagiri; Tomoichiro Asano; Masatoshi Tsuru; Kouichi Inukai; Hiraku Ono; Tatsuhiko Kodama; Masatoshi Kikuchi; Yoshitomo Oka
Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1385-94.
2002: Hideyuki Sakoda; Takehide Ogihara; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Yukiko Onishi; Hideki Katagiri; Miho Abe; Yasushi Fukushima; Nobuhiro Shojima; Kouichi Inukai; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1239-44.
2002: Hideki Katagiri; Tomoichiro Asano; Tetsuya Yamada; Toshifumi Aoyama; Yasushi Fukushima; Masatoshi Kikuchi; Tatsuhiko Kodama; Yoshitomo Oka
Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1049-59.
2002: Tomoichiro Asano; Yasushi Saito; Masanobu Kawakami; Nobuhiro Yamada
Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients.
Journal of diabetes and its complications 2002;16(2):133-8.
2002: Kaoruko Tada Iida; Hiroaki Suzuki; Hirohito Sone; Hitoshi Shimano; Hideo Toyoshima; Shigeru Yatoh; Tomoichiro Asano; Yukichi Okuda; Nobuhiro Yamada
Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):380-6.
2002: Moritoshi Sato; Takeaki Ozawa; Kouichi Inukai; Tomoichiro Asano; Yoshio Umezawa
Fluorescent indicators for imaging protein phosphorylation in single living cells.
Nature biotechnology 2002;20(3):287-94.
2002: Taro Fukao; Taketo Yamada; Masanobu Tanabe; Yasuo Terauchi; Takayuki Ota; Tetsuro Takayama; Tomoichiro Asano; Tsutomu Takeuchi; Takashi Kadowaki; Jun-ichi Hata Ji; Shigeo Koyasu
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice.
Nature immunology 2002;3(3):295-304.
2002: Tomohiro Kabuta; Fumihiko Hakuno; Tomoichiro Asano; Shin-Ichiro Takahashi
Insulin receptor substrate-3 functions as transcriptional activator in the nucleus.
The Journal of biological chemistry 2002;277(9):6846-51.
2002: Toshihiro Mochizuki; Akio Asai; Nobuhito Saito; Sakae Tanaka; Hideki Katagiri; Tomoichiro Asano; Makoto Nakane; Akira Tamura; Yoshiyuki Kuchino; Chifumi Kitanaka; Takaaki Kirino
Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide.
The Journal of biological chemistry 2002;277(4):2790-7.
2001: Y Onishi-Haraikawa; Masako Funaki; N Gotoh; Masabumi Shibuya; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Motonobu Anai; Toshio Ogihara; Hideyuki Sakoda; Hiraku Ono; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.
Biochemical and biophysical research communications 2001;288(2):476-82.
2001: Kaoruko Tada Iida; Hitoshi Shimano; Y Kawakami; Hirohito Sone; Hideo Toyoshima; S Suzuki; Tomoichiro Asano; Y Okuda; Nobuhiro Yamada
Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway.
The Journal of biological chemistry 2001;276(35):32531-7.
2001: Hiraku Ono; Hideki Katagiri; Masako Funaki; Motonobu Anai; Kouichi Inukai; Yasushi Fukushima; Hideyuki Sakoda; Toshio Ogihara; Yukiko Onishi; Midori Fujishiro; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1411-22.
2001: Yasushi Fukushima; Tatsuya Saitoh; Motonobu Anai; Toshio Ogihara; Kouichi Inukai; Masako Funaki; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Takashi Ishikawa; K Takata; Ryozo Nagai; Masao Omata; Tomoichiro Asano
Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting.
Biochimica et biophysica acta 2001;1539(3):181-91.
2001: Midori Fujishiro; Yukiko Gotoh; Hideki Katagiri; Hideyuki Sakoda; Toshio Ogihara; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Masako Funaki; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.
The Journal of biological chemistry 2001;276(23):19800-6.
2001: Akira Oku; Masao Nawano; Kiichiro Ueta; T Fujita; I Umebayashi; Kenji Arakawa; T Kano-Ishihara; Aya Saito; Motonobu Anai; Masako Funaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E816-24.
2001: Toshio Ogihara; Tomoichiro Asano; K Ando; Yuko Chiba; N Sekine; Hideyuki Sakoda; Motonobu Anai; Yukiko Onishi; Midori Fujishiro; Hiraku Ono; Nobuhiro Shojima; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; T Fujita
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.
Diabetes 2001;50(3):573-83.
2001: Tetsuya Yamada; Hideki Katagiri; Tomoichiro Asano; K Inukai; Masatoshi Tsuru; T Kodama; M Kikuchi; Yoshitomo Oka
3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells.
The Journal of biological chemistry 2001;276(7):5339-45.
2001: Kouichi Inukai; Masako Funaki; Motonobu Anai; Toshio Ogihara; Hideki Katagiri; Yasushi Fukushima; Hideyuki Sakoda; Y Onishi; H Ono; M Fujishiro; M Abe; Y Oka; M Kikuchi; Tomoichiro Asano
Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.
FEBS letters 2001;490(1-2):32-8.
2001: Yasushi Fukushima; Tatsuya Saitoh; Motonobu Anai; K Tsukuda; Yukiko Onishi; Hideyuki Sakoda; Kouichi Inukai; Toshio Ogihara; Masako Funaki; Hiraku Ono; Midori Fujishiro; Takashi Ishikawa; Ryozo Nagai; Masao Omata; Tomoichiro Asano
G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure.
The pharmacogenomics journal 2001;1(1):78-83.
2001: Yasushi Fukushima; H Otsuka; M Ishikawa; Tomoichiro Asano; Motonobu Anai; T Katsube; K Ogawa; T Kajiwara; S Ohkawa; Takashi Ishikawa; Masao Omata; Tatsuya Saitoh
Potent and long-lasting action of lafutidine on the human histamine H(2) receptor.
Digestion 2001;64(3):155-60.
2000: Ryuichi Aikawa; Masao Nawano; Y Gu; Hideki Katagiri; Tomoichiro Asano; Weidong Zhu; Ryozo Nagai; Issei Komuro
Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt.
Circulation 2000;102(23):2873-9.
2000: Toshiki Miura; Sakae Tanaka; Atsushi Seichi; Makoto Arai; Takahiro Goto; Hideki Katagiri; Tomoichiro Asano; Hiromi Oda; Kozo Nakamura
Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1.
Experimental neurology 2000;166(1):115-26.
2000: Hideyuki Sakoda; Toshio Ogihara; Motonobu Anai; Masako Funaki; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
Diabetes 2000;49(10):1700-8.
2000: Tomoichiro Asano; A Kanda; Hideki Katagiri; Masao Nawano; Toshio Ogihara; Kouichi Inukai; Motonobu Anai; Yasushi Fukushima; Yoshio Yazaki; Masatoshi Kikuchi; R Hooshmand-Rad; C H Heldin; Yoshitaka Oka; Masako Funaki
p110beta is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity.
The Journal of biological chemistry 2000;275(23):17671-6.
2000: Takeshi Ijuin; Y Mochizuki; Kiyoko Fukami; Masako Funaki; Tomoichiro Asano; Tadaomi Takenawa
Identification and characterization of a novel inositol polyphosphate 5-phosphatase.
The Journal of biological chemistry 2000;275(15):10870-5.
2000: Akira Oku; Kiichiro Ueta; Masao Nawano; Kenji Arakawa; T Kano-Ishihara; M Matsumoto; Aya Saito; K Tsujihara; Motonobu Anai; Tomoichiro Asano
Antidiabetic effect of T-1095, an inhibitor of Na(+)-glucose cotransporter, in neonatally streptozotocin-treated rats.
European journal of pharmacology 2000;391(1-2):183-92.
2000: Masao Nawano; Akira Oku; Kiichiro Ueta; I Umebayashi; T Ishirahara; Kenji Arakawa; Aya Saito; Motonobu Anai; Masatoshi Kikuchi; Tomoichiro Asano
Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats.
American journal of physiology. Endocrinology and metabolism 2000;278(3):E535-43.
2000: Kouichi Inukai; Masako Funaki; Masao Nawano; Hideki Katagiri; Toshio Ogihara; Motonobu Anai; Yukiko Onishi; Hideyuki Sakoda; Hiraku Ono; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin.
The Biochemical journal 2000;346 Pt 2():483-9.
2000: Tsuyoshi Miyazaki; H Katagiri; Yumi Kanegae; Hiroshi Takayanagi; Y Sawada; Aiichiro Yamamoto; Matthew Pando; Tomoichiro Asano; Inder M Verma; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts.
The Journal of cell biology 2000;148(2):333-42.
1999: Masao Nawano; Kiichiro Ueta; Akira Oku; Kenji Arakawa; Aya Saito; Masako Funaki; Motonobu Anai; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver.
Biochemical and biophysical research communications 1999;266(1):252-6.
1999: Yasushi Fukushima; Y Ohmachi; Tomoichiro Asano; Masao Nawano; Masako Funaki; Motonobu Anai; Toshio Ogihara; Kouichi Inukai; Yukiko Onishi; Hideyuki Sakoda; Tatsuya Saitoh; Nobuyuki Matsuhashi; Yoshio Yazaki; K Sugano
Localization of the histamine H(2) receptor, a target for antiulcer drugs, in gastric parietal cells.
Digestion 1999;60(6):522-7.
1999: Masao Nawano; Motonobu Anai; Masako Funaki; H Kobayashi; A Kanda; Yasushi Fukushima; Kouichi Inukai; Toshio Ogihara; Hideyuki Sakoda; Yukiko Onishi; Masatoshi Kikuchi; Yoshio Yazaki; Yoshitaka Oka; Tomoichiro Asano
Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.
Metabolism: clinical and experimental 1999;48(10):1248-55.
1999: Akira Oku; Kiichiro Ueta; Kenji Arakawa; Tomomi Ishihara; Masao Nawano; Y Kuronuma; M Matsumoto; Aya Saito; K Tsujihara; Motonobu Anai; Tomoichiro Asano; Y Kanai; H Endou
T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.
Diabetes 1999;48(9):1794-800.
1999: Masako Funaki; Hideki Katagiri; A Kanda; Motonobu Anai; Masao Nawano; Toshio Ogihara; Kouichi Inukai; Yasushi Fukushima; Hiraku Ono; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring.
The Journal of biological chemistry 1999;274(31):22019-24.
1999: Hideyuki Sakoda; Toshio Ogihara; Motonobu Anai; Masako Funaki; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Yukiko Onishi; Hiraku Ono; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.
Diabetes 1999;48(7):1365-71.
1999: H Ishihara; Teiji Wada; N Kizuki; Tomoichiro Asano; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka
Enhanced phosphoinositide hydrolysis via overexpression of phospholipase C beta1 or delta1 inhibits stimulus-induced insulin release in insulinoma MIN6 cells.
Biochemical and biophysical research communications 1999;254(1):77-82.
1999: Motonobu Anai; Masako Funaki; Toshio Ogihara; A Kanda; Yukiko Onishi; Hideyuki Sakoda; Kouichi Inukai; Masao Nawano; Yasushi Fukushima; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.
Diabetes 1999;48(1):158-69.
1998: Motonobu Anai; Hiraku Ono; Masako Funaki; Yasushi Fukushima; Kouichi Inukai; Toshio Ogihara; Hideyuki Sakoda; Yukiko Onishi; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2.
The Journal of biological chemistry 1998;273(45):29686-92.
1998: Takahiko Matsuda; Yuichi Hashimoto; H Ueda; Tomoichiro Asano; Yoshiharu Matsuura; T Doi; Toshifumi Takao; Y Shimonishi; Yoshitaka Fukada
Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.
Biochemistry 1998;37(27):9843-50.
1998: H Ishihara; Yoshikazu Shibasaki; N Kizuki; Teiji Wada; Yoshio Yazaki; Tomoichiro Asano; Yoshitaka Oka
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.
The Journal of biological chemistry 1998;273(15):8741-8.
1998: J Terasaki; Motonobu Anai; Masako Funaki; T Shibata; Kouichi Inukai; Toshio Ogihara; H Ishihara; Hideki Katagiri; Yukiko Onishi; Hideyuki Sakoda; Yasushi Fukushima; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet.
Diabetologia 1998;41(4):400-9.
1998: Motonobu Anai; Masako Funaki; Toshio Ogihara; J Terasaki; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.
Diabetes 1998;47(1):13-23.
1997: Toshio Ogihara; Toshiaki Isobe; Tohru Ichimura; Masato Taoka; Masako Funaki; Hideyuki Sakoda; Yukiko Onishi; Kouichi Inukai; Motonobu Anai; Yasushi Fukushima; Masatoshi Kikuchi; Yoshio Yazaki; Yoshitaka Oka; Tomoichiro Asano
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
The Journal of biological chemistry 1997;272(40):25267-74.
1997: Toshio Ogihara; Tomoichiro Asano
[Glucose transporter gene].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():473-7.
1997: Yukio Tanizawa; Shigeru Okuya; H Ishihara; Tomoichiro Asano; T Yada; Yoshitomo Oka
Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells.
Endocrinology 1997;138(10):4513-6.
1997: Yasushi Fukushima; Tomoichiro Asano; K Takata; Masako Funaki; Toshio Ogihara; Motonobu Anai; K Tsukuda; Tatsuya Saitoh; Hideki Katagiri; M Aihara; Nobuyuki Matsuhashi; Yoshitaka Oka; Yoshio Yazaki; K Sugano
Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonist-induced internalization.
The Journal of biological chemistry 1997;272(31):19464-70.
1997: Yasushi Fukushima; Tomoichiro Asano; T Saitoh; Motonobu Anai; Masako Funaki; Toshio Ogihara; Hideki Katagiri; Nobuyuki Matsuhashi; Yoshio Yazaki; K Sugano
Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells.
FEBS letters 1997;409(2):283-6.
1997: Toshio Ogihara; B C Shin; Motonobu Anai; Hideki Katagiri; Kouichi Inukai; Masako Funaki; Yasushi Fukushima; H Ishihara; K Takata; Masatoshi Kikuchi; Yoshio Yazaki; Yoshitaka Oka; Tomoichiro Asano
Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells.
The Journal of biological chemistry 1997;272(19):12868-73.
1997: T Murata; Hideki Katagiri; H Ishihara; Y Shibasaki; Tomoichiro Asano; Y Toyoda; B Pekiner; Can Pekiner; Ichitomo Miwa; Y Oka
Co-localization of glucokinase with actin filaments.
FEBS letters 1997;406(1-2):109-13.
1997: Kouichi Inukai; K Takata; Tomoichiro Asano; Hideki Katagiri; H Ishihara; Mitsuhiro Nakazaki; Yasushi Fukushima; Y Yazaki; Masatoshi Kikuchi; Yoshitaka Oka
Targeting of GLUT1-GLUT5 chimeric proteins in the polarized cell line Caco-2.
Molecular endocrinology (Baltimore, Md.) 1997;11(4):442-9.
1997: Kouichi Inukai; Masako Funaki; Toshio Ogihara; Hideki Katagiri; A Kanda; Motonobu Anai; Yasushi Fukushima; T Hosaka; Masato Suzuki; B C Shin; K Takata; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.
The Journal of biological chemistry 1997;272(12):7873-82.
1997: Yoshikazu Shibasaki; H Ishihara; N Kizuki; Tomoichiro Asano; Yoshitaka Oka; Yoshio Yazaki
Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo.
The Journal of biological chemistry 1997;272(12):7578-81.
1997: Hideki Katagiri; Tomoichiro Asano; Kouichi Inukai; Toshio Ogihara; H Ishihara; Yoshikazu Shibasaki; T Murata; J Terasaki; Masatoshi Kikuchi; Yoshio Yazaki; Yoshitaka Oka
Roles of PI 3-kinase and Ras on insulin-stimulated glucose transport in 3T3-L1 adipocytes.
The American journal of physiology 1997;272(2 Pt 1):E326-31.
1997: K Ueda; Yukio Tanizawa; Y Oota; H Inoue; N Kizuki; H Inoue; K Tsukuda; Tomoichiro Asano; Yoshitomo Oka
Prevalence of the Trp64Arg missense mutation of the beta3-adrenergic receptor gene in Japanese subjects.
Metabolism: clinical and experimental 1997;46(2):199-202.
1997: Yoshitaka Oka; T Hosaka; Hideki Katagiri; Tomoichiro Asano
Molecular mechanism of insulin-stimulated glucose transport in 3T3-L1 adipocytes.
The Japanese journal of physiology 1997;47 Suppl 1():S49.