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William Hauswirth

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Deng Wen-Tao; Sakurai Keisuke; Liu Jianwen; Dinculescu Astra; Li Jie; Pang Jijing; Min Seok-Hong; Chiodo Vince A; Boye Sanford L; Chang Bo; Kefalov Vladimir J; Hauswirth William W
Functional interchangeability of rod and cone transducin alpha-subunits.
Cideciyan Artur V; Hauswirth William W; Aleman Tomas S; Kaushal Shalesh; Schwartz Sharon B; Boye Sanford L; Windsor Elizabeth A M; Conlon Thomas J; Sumaroka Alexander; Pang Ji-Jing; Roman Alejandro J; Byrne Barry J; Jacobson Samuel G
Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year.
Tian Guilian; Zhou Yun; Hajkova Dagmar; Miyagi Masaru; Dinculescu Astra; Hauswirth William W; Palczewski Krzysztof; Geng Ruishuang; Alagramam Kumar N; Isosomppi Juha; Sankila Eeva-Marja; Flannery John G; Imanishi Yoshikazu
Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton.

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All Publications

2009: Deng Wen-Tao; Sakurai Keisuke; Liu Jianwen; Dinculescu Astra; Li Jie; Pang Jijing; Min Seok-Hong; Chiodo Vince A; Boye Sanford L; Chang Bo; Kefalov Vladimir J; Hauswirth William W
Functional interchangeability of rod and cone transducin alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17681-6.
2009: Cideciyan Artur V; Hauswirth William W; Aleman Tomas S; Kaushal Shalesh; Schwartz Sharon B; Boye Sanford L; Windsor Elizabeth A M; Conlon Thomas J; Sumaroka Alexander; Pang Ji-Jing; Roman Alejandro J; Byrne Barry J; Jacobson Samuel G
Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year.
Human gene therapy 2009;20(9):999-1004.
2009: Tian Guilian; Zhou Yun; Hajkova Dagmar; Miyagi Masaru; Dinculescu Astra; Hauswirth William W; Palczewski Krzysztof; Geng Ruishuang; Alagramam Kumar N; Isosomppi Juha; Sankila Eeva-Marja; Flannery John G; Imanishi Yoshikazu
Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton.
The Journal of biological chemistry 2009;284(28):18980-93.
2009: Petrs-Silva Hilda; Dinculescu Astra; Li Qiuhong; Min Seok-Hong; Chiodo Vince; Pang Ji-Jing; Zhong Li; Zolotukhin Sergei; Srivastava Arun; Lewin Alfred S; Hauswirth William W
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(3):463-71.
2009: Zadro-Lamoureux Laura A; Zacks David N; Baker Adam N; Zheng Qiong-Duan; Hauswirth William W; Tsilfidis Catherine
XIAP effects on retinal detachment-induced photoreceptor apoptosis [corrected].
Investigative ophthalmology & visual science 2009;50(3):1448-53.
2009: Li Wensheng; Kong Fansheng; Li Xia; Dai Xufeng; Liu Xiaoqiang; Zheng Qinxiang; Wu Ronghan; Zhou Xiangtian; Lü Fan; Chang Bo; Li Qiuhong; Hauswirth William W; Qu Jia; Pang Ji-Jing
Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye.
Molecular vision 2009;15():267-75.
2008: Hauswirth William W; Aleman Tomas S; Kaushal Shalesh; Cideciyan Artur V; Schwartz Sharon B; Wang Lili; Conlon Thomas J; Boye Sanford L; Flotte Terence R; Byrne Barry J; Jacobson Samuel G
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial.
Human gene therapy 2008;19(10):979-90.
2008: Li Qiuhong; Dinculescu Astra; Shan Zhiying; Miller Rehae; Pang Jijing; Lewin Alfred S; Raizada Mohan K; Hauswirth William W
Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(10):1688-94.
2008: Pang Ji-Jing; Boye Sanford L; Kumar Ashok; Dinculescu Astra; Deng Wentao; Li Jie; Li Qiuhong; Rani Asha; Foster Thomas C; Chang Bo; Hawes Norman L; Boatright Jeffrey H; Hauswirth William W
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.
Investigative ophthalmology & visual science 2008;49(10):4278-83.
2008: Cideciyan Artur V; Aleman Tomas S; Boye Sanford L; Schwartz Sharon B; Kaushal Shalesh; Roman Alejandro J; Pang Ji-Jing; Sumaroka Alexander; Windsor Elizabeth A M; Wilson James M; Flotte Terence R; Fishman Gerald A; Heon Elise; Stone Edwin M; Byrne Barry J; Jacobson Samuel G; Hauswirth William W
Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15112-7.
2008: Komáromy A M; Alexander J J; Cooper A E; Chiodo V A; Glushakova L G; Acland G M; Hauswirth W W; Aguirre G D
Targeting gene expression to cones with human cone opsin promoters in recombinant AAV.
Gene therapy 2008;15(14):1049-55.
2008: Alexander John J; Hauswirth William W
Prospects for retinal cone-targeted gene therapy.
Drug news & perspectives 2008;21(5):267-71.
2008: Janssen Andreas; Min Seok H; Molday Laurie L; Tanimoto Naoyuki; Seeliger Mathias W; Hauswirth William W; Molday Robert S; Weber Bernhard H F
Effect of late-stage therapy on disease progression in AAV-mediated rescue of photoreceptor cells in the retinoschisin-deficient mouse.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1010-7.
2008: Mauck Matthew C; Mancuso Katherine; Kuchenbecker James A; Connor Thomas B; Hauswirth William W; Neitz Jay; Neitz Maureen
Longitudinal evaluation of expression of virally delivered transgenes in gerbil cone photoreceptors.
Visual neuroscience 2008;25(3):273-82.
2008: Damiani Devid; Alexander John J; O'Rourke Jason R; McManus Mike; Jadhav Ashutosh P; Cepko Constance L; Hauswirth William W; Harfe Brian D; Strettoi Enrica
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(19):4878-87.
2008: Pang Ji-jing; Lauramore Amanda; Deng Wen-tao; Li Qiuhong; Doyle Thomas J; Chiodo Vince; Li Jie; Hauswirth William W
Comparative analysis of in vivo and in vitro AAV vector transduction in the neonatal mouse retina: effects of serotype and site of administration.
Vision research 2008;48(3):377-85.
2008: Li Qiuhong; Timmers Adrian M; Guy John; Pang Jijing; Hauswirth William W
Cone-specific expression using a human red opsin promoter in recombinant AAV.
Vision research 2008;48(3):332-8.
2008: Liu J; Saghizadeh M; Tuli S S; Kramerov A A; Lewin A S; Bloom D C; Hauswirth W W; Castro M G; Schultz G S; Ljubimov A V
Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy.
Molecular vision 2008;14():2087-96.
2008: Li Qiuhong; Miller Rehae; Han Ping-Yang; Pang Jijing; Dinculescu Astra; Chiodo Vince; Hauswirth William W
Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential.
Molecular vision 2008;14():1760-9.
2008: Raisler Brian J; Nozaki Miho; Baffi Judit; Hauswirth William W; Ambati Jayakrishna
Toward a higher fidelity model of AMD.
Advances in experimental medicine and biology 2008;613():185-92.
2008: Alexander John J; Hauswirth William W
Adeno-associated viral vectors and the retina.
Advances in experimental medicine and biology 2008;613():121-8.
2008: Gorbatyuk Marina S; Hauswirth William W; Lewin Alfred S
Gene therapy for mouse models of ADRP.
Advances in experimental medicine and biology 2008;613():107-12.
2007: McGill Trevor J; Prusky Glen T; Douglas Robert M; Yasumura Douglas; Matthes Michael T; Nune George; Donohue-Rolfe Kate; Yang Haidong; Niculescu Diana; Hauswirth William W; Girman Sergej V; Lund Raymond D; Duncan Jacque L; LaVail Matthew M
Intraocular CNTF reduces vision in normal rats in a dose-dependent manner.
Investigative ophthalmology & visual science 2007;48(12):5756-66.
2007: Qi Xiaoping; Sun Liang; Lewin Alfred S; Hauswirth William W; Guy John
Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy.
Investigative ophthalmology & visual science 2007;48(12):5360-70.
2007: Justilien Verline; Pang Ji-Jing; Renganathan Kutralanathan; Zhan Xianquan; Crabb John W; Kim So Ra; Sparrow Janet R; Hauswirth William W; Lewin Alfred S
SOD2 knockdown mouse model of early AMD.
Investigative ophthalmology & visual science 2007;48(10):4407-20.
2007: Aarnisalo A A; Pietola L; Joensuu J; Isosomppi J; Aarnisalo P; Dinculescu A; Lewin A S; Flannery J; Hauswirth W W; Sankila E-M; Jero J
Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse cochlea.
Hearing research 2007;230(1-2):9-16.
2007: Aguirre Geoffrey K; Komáromy András M; Cideciyan Artur V; Brainard David H; Aleman Tomas S; Roman Alejandro J; Avants Brian B; Gee James C; Korczykowski Marc; Hauswirth William W; Acland Gregory M; Aguirre Gustavo D; Jacobson Samuel G
Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation.
PLoS medicine 2007;4(6):e230.
2007: Alexander John J; Umino Yumiko; Everhart Drew; Chang Bo; Min Seok H; Li Qiuhong; Timmers Adrian M; Hawes Norman L; Pang Ji-Jing; Barlow Robert B; Hauswirth William W
Restoration of cone vision in a mouse model of achromatopsia.
Nature medicine 2007;13(6):685-7.
2007: Kwon Brian K; Liu Jie; Lam Clarrie; Plunet Ward; Oschipok Loren W; Hauswirth William; Di Polo Adriana; Blesch Armin; Tetzlaff Wolfram
Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury.
Spine 2007;32(11):1164-73.
2007: White D Alan; Fritz Jason J; Hauswirth William W; Kaushal Shalesh; Lewin Alfred S
Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease.
Investigative ophthalmology & visual science 2007;48(5):1942-51.
2007: Gorbatyuk M; Justilien V; Liu J; Hauswirth W W; Lewin A S
Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery.
Vision research 2007;47(9):1202-8.
2007: Rhee Kun Do; Ruiz Alberto; Duncan Jacque L; Hauswirth William W; Lavail Matthew M; Bok Dean; Yang Xian-Jie
Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa.
Investigative ophthalmology & visual science 2007;48(3):1389-400.
2007: Qi Xiaoping; Sun Liang; Hauswirth William W; Lewin Alfred S; Guy John
Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation.
Archives of ophthalmology 2007;125(2):268-72.
2007: Qi Xiaoping; Lewin Alfred S; Sun Liang; Hauswirth William W; Guy John
Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis.
Investigative ophthalmology & visual science 2007;48(2):681-91.
2007: Qi Xiaoping; Sun Liang; Lewin Alfred S; Hauswirth William W; Guy John
The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse.
Investigative ophthalmology & visual science 2007;48(1):1-10.
2007: Gorbatyuk M; Justilien V; Liu J; Hauswirth W W; Lewin A S
Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme.
Experimental eye research 2007;84(1):44-52.
2007: Andino Lourdes M; Conlon Thomas J; Porvasnik Stacy L; Boye Sanford L; Hauswirth William W; Lewin Alfred S
Rapid, widespread transduction of the murine myocardium using self-complementary Adeno-associated virus.
Genetic vaccines and therapy 2007;5():13.
2007: Roman Alejandro J; Boye Sanford L; Aleman Tomas S; Pang Ji-jing; McDowell J Hugh; Boye Shannon E; Cideciyan Artur V; Jacobson Samuel G; Hauswirth William W
Electroretinographic analyses of Rpe65-mutant rd12 mice: developing an in vivo bioassay for human gene therapy trials of Leber congenital amaurosis.
Molecular vision 2007;13():1701-10.
2007: Leonard Kevin C; Petrin Dino; Coupland Stuart G; Baker Adam N; Leonard Brian C; LaCasse Eric C; Hauswirth William W; Korneluk Robert G; Tsilfidis Catherine
XIAP protection of photoreceptors in animal models of retinitis pigmentosa.
PloS one 2007;2(3):e314.
2007: Qi Xiaoping; Hauswirth William W; Guy John
Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis.
Molecular vision 2007;13():1-11.
2006: Qi Xiaoping; Lewin Alfred S; Sun Liang; Hauswirth William W; Guy John
Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis.
The Journal of biological chemistry 2006;281(42):31950-62.
2006: Nusinowitz S; Ridder W H; Pang J J; Chang B; Noorwez S M; Kaushal S; Hauswirth W W; Heckenlively J R
Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function.
Vision research 2006;46(22):3926-34.
2006: Haire Shannon E; Pang Jijing; Boye Sanford L; Sokal Izabel; Craft Cheryl M; Palczewski Krzysztof; Hauswirth William W; Semple-Rowland Susan L
Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1.
Investigative ophthalmology & visual science 2006;47(9):3745-53.
2006: Jacobson Samuel G; Boye Sanford L; Aleman Tomas S; Conlon Thomas J; Zeiss Caroline J; Roman Alejandro J; Cideciyan Artur V; Schwartz Sharon B; Komaromy Andras M; Doobrajh Michelle; Cheung Andy Y; Sumaroka Alexander; Pearce-Kelling Susan E; Aguirre Gustavo D; Kaushal Shalesh; Maguire Albert M; Flotte Terence R; Hauswirth William W
Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis.
Human gene therapy 2006;17(8):845-58.
2006: Glushakova Lyudmyla G; Timmers Adrian M; Pang Jijing; Teusner Jacqueline T; Hauswirth William W
Human blue-opsin promoter preferentially targets reporter gene expression to rat s-cone photoreceptors.
Investigative ophthalmology & visual science 2006;47(8):3505-13.
2006: Jacobson Samuel G; Acland Gregory M; Aguirre Gustavo D; Aleman Tomas S; Schwartz Sharon B; Cideciyan Artur V; Zeiss Caroline J; Komaromy Andras M; Kaushal Shalesh; Roman Alejandro J; Windsor Elizabeth A M; Sumaroka Alexander; Pearce-Kelling Susan E; Conlon Thomas J; Chiodo Vincent A; Boye Sanford L; Flotte Terence R; Maguire Albert M; Bennett Jean; Hauswirth William W
Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(6):1074-84.
2006: Sapieha Przemyslaw S; Hauswirth William W; Di Polo Adriana
Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2.
Journal of neuroscience research 2006;83(6):985-95.
2006: Pang Ji-jing; Chang Bo; Kumar Ashok; Nusinowitz Steven; Noorwez Syed M; Li Jie; Rani Asha; Foster Thomas C; Chiodo Vince A; Doyle Thomas; Li Huashi; Malhotra Ritu; Teusner Jacqueline T; McDowell J Hugh; Min Seok-Hong; Li Qiuhong; Kaushal Shalesh; Hauswirth William W
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):565-72.
2006: Renwick J; Narang M A; Coupland S G; Xuan J Y; Baker A N; Brousseau J; Petrin D; Munger R; Leonard B C; Hauswirth W W; Korneluk R G; Tsilfidis C
XIAP-mediated neuroprotection in retinal ischemia.
Gene therapy 2006;13(4):339-47.
2006: Molday Laurie L; Min Seok-Hong; Seeliger Mathias W; Wu Winco W H; Dinculescu Astra; Timmers Adrian M; Janssen Andreas; Tonagel Felix; Hudl Kristiane; Weber Bernhard H F; Hauswirth William W; Molday Robert S
Disease mechanisms and gene therapy in a mouse model for X-linked retinoschisis.
Advances in experimental medicine and biology 2006;572():283-9.
2006: Teusner Jacqueline T; Lewin Alfred S; Hauswirth William W
Down-regulation of rhodopsin gene expression by AAV-vectored short interfering RNA.
Advances in experimental medicine and biology 2006;572():233-8.
2006: Glushakova Lyudmyla G; Timmers Adrian M; Issa Tawfik M; Cortez Nenita G; Pang Jijing; Teusner Jacqueline T; Hauswirth William W
Does recombinant adeno-associated virus-vectored proximal region of mouse rhodopsin promoter support only rod-type specific expression in vivo?
Molecular vision 2006;12():298-309.
2005: Hauswirth William W
The consortium project to treat RPE65 deficiency in humans.
Retina (Philadelphia, Pa.) 2005;25(8 Suppl):S60.
2005: Mu Wei; Ouyang Xiaosen; Agarwal Anupam; Zhang Li; Long David A; Cruz Pedro E; Roncal Carlos A; Glushakova Olena Y; Chiodo Vince A; Atkinson Mark A; Hauswirth William W; Flotte Terry R; Rodriguez-Iturbe Bernardo; Johnson Richard J
IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease.
Journal of the American Society of Nephrology : JASN 2005;16(12):3651-60.
2005: Acland Gregory M; Aguirre Gustavo D; Bennett Jean; Aleman Tomas S; Cideciyan Artur V; Bennicelli Jeannette; Dejneka Nadine S; Pearce-Kelling Susan E; Maguire Albert M; Palczewski Krzysztof; Hauswirth William W; Jacobson Samuel G
Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1072-82.
2005: Deng Wen-Tao; Yan Zuan; Dinculescu Astra; Pang Jijing; Teusner Jacqueline T; Cortez Nenita G; Berns Kenneth I; Hauswirth William W
Adeno-associated virus-mediated expression of vascular endothelial growth factor peptides inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Human gene therapy 2005;16(11):1247-54.
2005: Liu Jianwen; Timmers Adrian M; Lewin Alfred S; Hauswirth William W
Ribozyme knockdown of the gamma-subunit of rod cGMP phosphodiesterase alters the ERG and retinal morphology in wild-type mice.
Investigative ophthalmology & visual science 2005;46(10):3836-44.
2005: Min Seok H; Molday Laurie L; Seeliger Mathias W; Dinculescu Astra; Timmers Adrian M; Janssen Andreas; Tonagel Felix; Tanimoto Naoyuki; Weber Bernhard H F; Molday Robert S; Hauswirth William W
Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of x-linked juvenile retinoschisis.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):644-51.
2005: Loiler Scott A; Tang Qiushi; Clarke Tracy; Campbell-Thompson Martha L; Chiodo Vince; Hauswirth William; Cruz Pedro; Perret-Gentil Marcel; Atkinson Mark A; Ramiya Vijayakumar K; Flotte Terence R
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):519-27.
2005: Zhou Yu; Pernet Vincent; Hauswirth William W; Di Polo Adriana
Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):402-12.
2005: Dinculescu Astra; Glushakova Lyudmyla; Min Seok-Hong; Hauswirth William W
Adeno-associated virus-vectored gene therapy for retinal disease.
Human gene therapy 2005;16(6):649-63.
2005: Chen Sifeng; Kapturczak Matthias H; Wasserfall Clive; Glushakova Olena Y; Campbell-Thompson Martha; Deshane Jessy S; Joseph Reny; Cruz Pedro E; Hauswirth William W; Madsen Kirsten M; Croker Byron P; Berns Kenneth I; Atkinson Mark A; Flotte Terence R; Tisher C Craig; Agarwal Anupam
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7251-6.
2005: Pernet Vincent; Hauswirth William W; Di Polo Adriana
Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo.
Journal of neurochemistry 2005;93(1):72-83.
2005: Pang Ji-Jing; Chang Bo; Hawes Norman L; Hurd Ronald E; Davisson Muriel T; Li Jie; Noorwez Syed M; Malhotra Ritu; McDowell J Hugh; Kaushal Shalesh; Hauswirth William W; Nusinowitz Steven; Thompson Debra A; Heckenlively John R
Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA).
Molecular vision 2005;11():152-62.
2005: Chen Sifeng; Kapturczak Matthias; Loiler Scott A; Zolotukhin Sergei; Glushakova Olena Y; Madsen Kirsten M; Samulski Richard J; Hauswirth William W; Campbell-Thompson Martha; Berns Kenneth I; Flotte Terence R; Atkinson Mark A; Tisher C Craig; Agarwal Anupam
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy 2005;16(2):235-47.
2005: Gorbatyuk M S; Pang J J; Thomas J; Hauswirth William W; Lewin Alfred S
Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approach.
Molecular vision 2005;11():648-56.
2004: Qi Xiaoping; Lewin Alfred S; Sun Liang; Hauswirth William W; Guy John
SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I.
Annals of neurology 2004;56(2):182-91.
2004: Fritz Jason J; Gorbatyuk Marina; Lewin Alfred S; Hauswirth William W
Design and validation of therapeutic hammerhead ribozymes for autosomal dominant diseases.
Methods in molecular biology (Clifton, N.J.) 2004;252():221-36.
2004: Hauswirth William W; Li Quihong; Raisler Brian; Timmers Adrian M; Berns Kenneth I; Flannery John G; LaVail Matthew M; Lewin Alfred S
Range of retinal diseases potentially treatable by AAV-vectored gene therapy.
Novartis Foundation symposium 2004;255():179-88; discussion 188-94.
2003: Kanadia Rahul N; Johnstone Karen A; Mankodi Ami; Lungu Codrin; Thornton Charles A; Esson Douglas; Timmers Adrian M; Hauswirth William W; Swanson Maurice S
A muscleblind knockout model for myotonic dystrophy.
Science (New York, N.Y.) 2003;302(5652):1978-80.
2003: Petrin Dino; Baker Adam; Coupland Stuart G; Liston Peter; Narang Monica; Damji Karim; Leonard Brian; Chiodo Vince A; Timmers Adrian; Hauswirth William; Korneluk Robert G; Tsilfidis Catherine
Structural and functional protection of photoreceptors from MNU-induced retinal degeneration by the X-linked inhibitor of apoptosis.
Investigative ophthalmology & visual science 2003;44(6):2757-63.
2003: Chen Sifeng; Agarwal Anupam; Glushakova Olena Y; Jorgensen Marda S; Salgar Shashikumar K; Poirier Amy; Flotte Terence R; Croker Byron P; Madsen Kirsten M; Atkinson Mark A; Hauswirth William W; Berns Kenneth I; Tisher C Craig
Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors.
Journal of the American Society of Nephrology : JASN 2003;14(4):947-58.
2003: Qi Xiaoping; Lewin Alfred S; Hauswirth William W; Guy John
Optic neuropathy induced by reductions in mitochondrial superoxide dismutase.
Investigative ophthalmology & visual science 2003;44(3):1088-96.
2003: Qi Xiaoping; Lewin Alfred S; Hauswirth William W; Guy John
Suppression of complex I gene expression induces optic neuropathy.
Annals of neurology 2003;53(2):198-205.
2003: Petrin Dino; Baker Adam; Brousseau Jennifer; Coupland Stuart; Liston Peter; Hauswirth William W; Komeluk Robert G; Tsilfidis Catherine
XIAP protects photoreceptors from n-methyl-n-nitrosourea-induced retinal degeneration.
Advances in experimental medicine and biology 2003;533():385-93.
2002: Guy John; Qi Xiaoping; Pallotti Francesco; Schon Eric A; Manfredi Giovanni; Carelli Valerio; Martinuzzi Andrea; Hauswirth William W; Lewin Alfred S
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
Annals of neurology 2002;52(5):534-42.
2002: Fritz Jason Jon; Lewin Alfred; Hauswirth William; Agarwal Anupam; Grant Maria; Shaw Lynn
Development of hammerhead ribozymes to modulate endogenous gene expression for functional studies.
Methods (San Diego, Calif.) 2002;28(2):276-85.
2002: Zolotukhin Sergei; Potter Mark; Zolotukhin Irene; Sakai Yoshihisa; Loiler Scott; Fraites Thomas J; Chiodo Vince A; Phillipsberg Tina; Muzyczka Nicholas; Hauswirth William W; Flotte Terance R; Byrne Barry J; Snyder Richard O
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.
Methods (San Diego, Calif.) 2002;28(2):158-67.
2002: Bok Dean; Yasumura Douglas; Matthes Michael T; Ruiz Alberto; Duncan Jacque L; Chappelow Aimee V; Zolutukhin Sergei; Hauswirth William; LaVail Matthew M
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation.
Experimental eye research 2002;74(6):719-35.
2002: Raisler Brian J; Berns Kenneth I; Grant Maria B; Beliaev Denis; Hauswirth William W
Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8909-14.
2002: Mori Keisuke; Gehlbach Peter; Yamamoto Satoru; Duh Elia; Zack Donald J; Li Quihong; Berns Kenneth I; Raisler Brian J; Hauswirth William W; Campochiaro Peter A
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.
Investigative ophthalmology & visual science 2002;43(6):1994-2000.
2002: McKinnon Stuart J; Lehman Donna M; Tahzib N Grace; Ransom Nancy L; Reitsamer Herbert A; Liston Peter; LaCasse Eric; Li Qiuhong; Korneluk Robert G; Hauswirth William W
Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(6):780-7.
2002: Cheng Li; Sapieha Przemyslaw; Kittlerova Pavla; Hauswirth William W; Di Polo Adriana
TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):3977-86.
2002: Ghivizzani Steven C; Madsen Cort S; Ammini Chandramohan V; Hauswirth William W
In organello footprinting of mtDNA.
Methods in molecular biology (Clifton, N.J.) 2002;197():363-75.
2002: Fritz Jason J; White D Alan; Lewin Alfred S; Hauswirth William W
Designing and characterizing hammerhead ribozymes for use in AAV vector-mediated retinal gene therapies.
Methods in enzymology 2002;346():358-77.
2001: McGee Sanftner L H; Abel H; Hauswirth W W; Flannery J G
Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):622-9.
2001: Li Q; Timmers A M; Hunter K; Gonzalez-Pola C; Lewin A S; Reitze D H; Hauswirth W W
Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse.
Investigative ophthalmology & visual science 2001;42(12):2981-9.
2001: Acland G M; Aguirre G D; Ray J; Zhang Q; Aleman T S; Cideciyan A V; Pearce-Kelling S E; Anand V; Zeng Y; Maguire A M; Jacobson S G; Hauswirth W W; Bennett J
Gene therapy restores vision in a canine model of childhood blindness.
Nature genetics 2001;28(1):92-5.
2001: Lewin A S; Hauswirth W W
Ribozyme gene therapy: applications for molecular medicine.
Trends in molecular medicine 2001;7(5):221-8.
2001: Shaw L C; Skold A; Wong F; Petters R; Hauswirth W W; Lewin A S
An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa.
Molecular vision 2001;7():6-13.
2001: Berns K I; Meneses P; Duvoisin R; Laipis P; Hauswirth W
Use of recombinant angiostatin to prevent retinal neovascularization.
Transactions of the American Clinical and Climatological Association 2001;112():68-75; discussion 75-6.
2000: Hauswirth W W; Lewin A S
Ribozyme uses in retinal gene therapy.
Progress in retinal and eye research 2000;19(6):689-710.
2000: Owen R I V; Lewin A P; Peel A; Wang J; Guy J; Hauswirth W W; Stacpoole P W; Flotte T R
Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism.
Human gene therapy 2000;11(15):2067-78.
2000: LaVail M M; Yasumura D; Matthes M T; Drenser K A; Flannery J G; Lewin A S; Hauswirth W W
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11488-93.
2000: Hauswirth W W; Beaufrere L
Ocular gene therapy: quo vadis?
Investigative ophthalmology & visual science 2000;41(10):2821-6.
2000: Hauswirth W W; LaVail M M; Flannery J G; Lewin A S
Ribozyme gene therapy for autosomal dominant retinal disease.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(2):147-53.
2000: Hauswirth W W; Timmers A M
The eyes have it.
Molecular medicine today 2000;6(2):51.
2000: Shaw L C; Whalen P O; Drenser K A; Yan W; Hauswirth W W; Lewin A S
Ribozymes in treatment of inherited retinal disease.
Methods in enzymology 2000;316():761-76.
2000: Hauswirth W W; Lewin A S; Zolotukhin S; Muzyczka N
Production and purification of recombinant adeno-associated virus.
Methods in enzymology 2000;316():743-61.
1999: Guy J; Qi X; Wang H; Hauswirth W W
Adenoviral gene therapy with catalase suppresses experimental optic neuritis.
Archives of ophthalmology 1999;117(11):1533-9.
1999: Guy J; Qi X; Muzyczka N; Hauswirth W W
Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve.
Archives of ophthalmology 1999;117(7):929-37.
1999: Ammini C V; Hauswirth W W
Mitochondrial gene expression is regulated at the level of transcription during early embryogenesis of Xenopus laevis.
The Journal of biological chemistry 1999;274(10):6265-71.
1998: Yan W; Lewin A; Hauswirth W
Selective degradation of nonsense beta-phosphodiesterase mRNA in the heterozygous rd mouse.
Investigative ophthalmology & visual science 1998;39(13):2529-36.
1998: Guy J; Qi X; Hauswirth W W
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13847-52.
1998: Lewin A S; Drenser K A; Hauswirth W W; Nishikawa S; Yasumura D; Flannery J G; LaVail M M
Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.
Nature medicine 1998;4(8):967-71.
1998: Hauswirth W W; McInnes R R
Retinal gene therapy 1998: summary of a workshop.
Molecular vision 1998;4():11.
1998: Drenser K A; Timmers A M; Hauswirth W W; Lewin A S
Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa.
Investigative ophthalmology & visual science 1998;39(5):681-9.
1997: Flannery J G; Zolotukhin S; Vaquero M I; LaVail M M; Muzyczka N; Hauswirth W W
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6916-21.
1996: Zolotukhin S; Potter M; Hauswirth W W; Guy J; Muzyczka N
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells.
Journal of virology 1996;70(7):4646-54.
1996: DesJardin L E; Hauswirth W W
Developmentally important DNA elements within the bovine opsin upstream region.
Investigative ophthalmology & visual science 1996;37(1):154-65.
1996: Ammini C V; Ghivizzani S C; Madsen C S; Hauswirth W W
Genomic footprinting of mitochondrial DNA: II. In vivo analysis of protein-mitochondrial DNA interactions in Xenopus laevis eggs and embryos.
Methods in enzymology 1996;264():23-36.
1996: Madsen C S; Ghivizzani S C; Ammini C V; Nelen M R; Hauswirth W W
Genomic footprinting of mitochondrial DNA: I. In organello analysis of protein-mitochondrial DNA interactions in bovine mitochondria.
Methods in enzymology 1996;264():12-22.
1995: van Ginkel P R; Timmers A M; Szél A; Hauswirth W W
Topographical regulation of cone and rod opsin genes: parallel, position dependent levels of transcription.
Brain research. Developmental brain research 1995;89(1):146-9.
1995: Timmers A M; Wintjes E T; Hauswirth W W
Fetal topography of bovine rhodopsin mRNA suggests retinotopographically determined gene expression.
Investigative ophthalmology & visual science 1995;36(10):2008-19.
1995: Muise R C; Hauswirth W W
Selective DNA amplification regulates transcript levels in plant mitochondria.
Current genetics 1995;28(2):113-21.
1995: DesJardin L E; Lockwood M K; Hauswirth W W
Bovine opsin gene expression exhibits a late fetal to adult regulatory switch.
Journal of neuroscience research 1995;40(6):728-36.
1994: Ghivizzani S C; Madsen C S; Nelen M R; Ammini C V; Hauswirth W W
In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replication.
Molecular and cellular biology 1994;14(12):7717-30.
1994: Hauswirth W W; Dickel C D; Rowold D J; Hauswirth M A
Inter- and intrapopulation studies of ancient humans.
Experientia 1994;50(6):585-91.
1994: Hauswirth W W
Ancient DNA: an introduction.
Experientia 1994;50(6):521-3.
1994: van Ginkel P R; Hauswirth W W
Parallel regulation of fetal gene expression in different photoreceptor cell types.
The Journal of biological chemistry 1994;269(7):4986-92.
1993: Madsen C S; Ghivizzani S C; Hauswirth W W
In vivo and in vitro evidence for slipped mispairing in mammalian mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7671-5.
1993: Ghivizzani S C; Mackay S L; Madsen C S; Laipis P J; Hauswirth W W
Transcribed heteroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region.
Journal of molecular evolution 1993;37(1):36-7.
1993: Ghivizzani S C; Madsen C S; Hauswirth W W
In organello footprinting. Analysis of protein binding at regulatory regions in bovine mitochondrial DNA.
The Journal of biological chemistry 1993;268(12):8675-82.
1993: DesJardin L E; Timmers A M; Hauswirth W W
Transcription of photoreceptor genes during fetal retinal development. Evidence for positive and negative regulation.
The Journal of biological chemistry 1993;268(10):6953-60.
1993: Madsen C S; Ghivizzani S C; Hauswirth W W
Protein binding to a single termination-associated sequence in the mitochondrial DNA D-loop region.
Molecular and cellular biology 1993;13(4):2162-71.
1993: Timmers A M; Newton B R; Hauswirth W W
Synthesis and stability of retinal photoreceptor mRNAs are coordinately regulated during bovine fetal development.
Experimental eye research 1993;56(3):257-65.
1992: Muise R C; Hauswirth W W
Transcription in maize mitochondria: effects of tissue and mitochondrial genotype.
Current genetics 1992;22(3):235-42.
1992: Hehman G L; Hauswirth W W
DNA helicase from mammalian mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8562-6.
1992: Hauswirth W W; Langerijt A V; Timmers A M; Adamus G; Ulshafer R J
Early expression and localization of rhodopsin and interphotoreceptor retinoid-binding protein (IRBP) in the developing fetal bovine retina.
Experimental eye research 1992;54(5):661-70.
1991: Lawlor D A; Dickel C D; Hauswirth W W; Parham P
Ancient HLA genes from 7,500-year-old archaeological remains.
Nature 1991;349(6312):785-8.
1989: Ashley M V; Laipis P J; Hauswirth W W
Rapid segregation of heteroplasmic bovine mitochondria.
Nucleic acids research 1989;17(18):7325-31.
1988: Laipis P J; Van de Walle M J; Hauswirth W W
Unequal partitioning of bovine mitochondrial genotypes among siblings.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8107-10.
1988: McCarty D M; Hehman G L; Hauswirth W W
Nucleotide sequence of the Zea mays mitochondrial cytochrome oxidase subunit III gene.
Nucleic acids research 1988;16(20):9873.
1988: Fejes E; Masters B S; McCarty D M; Hauswirth W W
Sequence and transcriptional analysis of a chloroplast insert in the mitochondrial genome of Zea mays.
Current genetics 1988;13(6):509-15.
1986: Doran G H; Dickel D N; Ballinger W E; Agee O F; Laipis P J; Hauswirth W W
Anatomical, cellular and molecular analysis of 8,000-yr-old human brain tissue from the Windover archaeological site.
Nature 1986;323(6091):803-6.
1986: MacKay S L; Olivo P D; Laipis P J; Hauswirth W W
Template-directed arrest of mammalian mitochondrial DNA synthesis.
Molecular and cellular biology 1986;6(4):1261-7.
1986: Tanhauser S M; Hauswirth W W; Laipis P J
Conserved restriction sites within the ribosomal RNA genes of vertebrates.
Biochimica et biophysica acta 1986;866(1):19-25.
1984: Hauswirth W W; Van de Walle M J; Laipis P J; Olivo P D
Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue.
Cell 1984;37(3):1001-7.
1983: Olivo P D; Van de Walle M J; Laipis P J; Hauswirth W W
Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop.
Nature 1983;306(5941):400-2.
1982: Michaels G S; Hauswirth W W; Laipis P J
Mitochondrial DNA copy number in bovine oocytes and somatic cells.
Developmental biology 1982;94(1):246-51.
1982: Hauswirth W W; Laipis P J
Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4686-90.
1980: Hauswirth W W; Laipis P J; Gilman M E; O'Brien T W; Michaels G S; Rayfield M A
Genetic mapping of bovine mitochondrial DNA from a single animal.
Gene 1980;8(2):193-209.

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