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Louis Havekes

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
63
Frants, Rune
57
Hofker, Marten
51
Willems van Dijk, Ko
47
Romijn, Johannes
41
Voshol, Peter
39
van Vlijmen, Bart
30
Rensen, Patrick
26
Princen, Hans
23
Dahlmans, Vivian
21
Jong, Miek
21
Smelt, August
21
Kuipers, Folkert
19
de Knijff, Peter
19
de Wit, Elly
18
Jukema, Wouter

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Publications

TOP 3
de Vries-van der Weij Jitske; Zadelaar Susanne; Toet Karin; Havekes Louis M; Kooistra Teake; Rensen Patrick C N
Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice.
Voshol Peter J; Rensen Patrick C N; van Dijk Ko Willems; Romijn Johannes A; Havekes Louis M
Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models.
de Vries-van der Weij Jitske; de Haan Willeke; Hu Lihui; Kuif Maarten; Oei H Ling D W; van der Hoorn José W A; Havekes Louis M; Princen Hans M G; Romijn Johannes A; Smit Johannes W A; Rensen Patrick C N
Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.

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All Publications

2009: de Vries-van der Weij Jitske; Zadelaar Susanne; Toet Karin; Havekes Louis M; Kooistra Teake; Rensen Patrick C N
Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice.
Atherosclerosis 2009;206(1):153-8.
2009: Voshol Peter J; Rensen Patrick C N; van Dijk Ko Willems; Romijn Johannes A; Havekes Louis M
Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models.
Biochimica et biophysica acta 2009;1791(6):479-85.
2009: de Vries-van der Weij Jitske; de Haan Willeke; Hu Lihui; Kuif Maarten; Oei H Ling D W; van der Hoorn José W A; Havekes Louis M; Princen Hans M G; Romijn Johannes A; Smit Johannes W A; Rensen Patrick C N
Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.
Endocrinology 2009;150(5):2368-75.
2009: Henneman Peter; van der Sman-de Beer Femke; Moghaddam Payman Hanifi; Huijts Petra; Stalenhoef Anton F H; Kastelein John J P; van Duijn Cornelia M; Havekes Louis M; Frants Rune R; van Dijk Ko Willems; Smelt Augustinus H M
The expression of type III hyperlipoproteinemia: involvement of lipolysis genes.
European journal of human genetics : EJHG 2009;17(5):620-8.
2009: de Haan Willeke; de Vries-van der Weij Jitske; Mol Isabel M; Hoekstra Menno; Romijn Johannes A; Jukema J Wouter; Havekes Louis M; Princen Hans M G; Rensen Patrick C N
PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice.
Biochimica et biophysica acta 2009;1791(3):191-7.
2008: de Haan Willeke; Out Ruud; Berbée Jimmy F P; van der Hoogt Caroline C; van Dijk Ko Willems; van Berkel Theo J C; Romijn Johannes A; Jukema J Wouter; Havekes Louis M; Rensen Patrick C N
Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.
Biochemical and biophysical research communications 2008;377(4):1294-8.
2008: van der Hoorn José W A; de Haan Willeke; Berbée Jimmy F P; Havekes Louis M; Jukema J Wouter; Rensen Patrick C N; Princen Hans M G
Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(11):2016-22.
2008: van den Hoek Anita M; van Heijningen Caroline; Schröder-van der Elst Janny P; Ouwens D Margriet; Havekes Louis M; Romijn Johannes A; Kalsbeek Andries; Pijl Hanno
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation.
Diabetes 2008;57(9):2304-10.
2008: DeRuiter Marco C; Alkemade Fanneke E; Gittenberger-de Groot Adriana C; Poelmann Robert E; Havekes Louis M; van Dijk Ko Willems
Maternal transmission of risk for atherosclerosis.
Current opinion in lipidology 2008;19(4):333-7.
2008: Schippers Emile F; Berbée Jimmy F P; van Disseldorp Inge M; Versteegh Michael I M; Havekes Louis M; Rensen Patrick C N; van Dissel Jaap T
Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery.
Intensive care medicine 2008;34(8):1492-7.
2008: Romijn Johannes A; Corssmit Eleonora P; Havekes Louis M; Pijl Hanno
Gut-brain axis.
Current opinion in clinical nutrition and metabolic care 2008;11(4):518-21.
2008: Hu Lihui; van der Hoogt Caroline C; Espirito Santo Sonia M S; Out Ruud; Kypreos Kyriakos E; van Vlijmen Bart J M; Van Berkel Theo J C; Romijn Johannes A; Havekes Louis M; van Dijk Ko Willems; Rensen Patrick C N
The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI.
Journal of lipid research 2008;49(7):1553-61.
2008: de Haan Willeke; de Vries-van der Weij Jitske; van der Hoorn José W A; Gautier Thomas; van der Hoogt Caroline C; Westerterp Marit; Romijn Johannes A; Jukema J Wouter; Havekes Louis M; Princen Hans M G; Rensen Patrick C N
Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin.
Circulation 2008;117(19):2515-22.
2008: Gerritsen Gery; van der Hoogt Caroline C; Schaap Frank G; Voshol Peter J; Kypreos Kyriakos E; Maeda Nobuyo; Groen Albert K; Havekes Louis M; Rensen Patrick C N; van Dijk Ko Willems
ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency.
Journal of lipid research 2008;49(5):1048-55.
2008: Berbée Jimmy F P; van der Hoogt Caroline C; de Haas Carla J C; van Kessel Kok P M; Dallinga-Thie Geesje M; Romijn Johannes A; Havekes Louis M; van Leeuwen Henk J; Rensen Patrick C N
Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis.
Intensive care medicine 2008;34(5):907-11.
2008: Nagelkerken Lex; Verzaal Perry; Lagerweij Tonny; Persoon-Deen Carla; Berbee Jimmy F P; Prens Errol P; Havekes Louis M; Oranje Arnold P
Development of atopic dermatitis in mice transgenic for human apolipoprotein C1.
The Journal of investigative dermatology 2008;128(5):1165-72.
2008: Abildayeva Karlygash; Berbée Jimmy F P; Blokland Arjan; Jansen Paula J; Hoek Frans J; Meijer Onno; Lütjohann Dieter; Gautier Thomas; Pillot Thierry; De Vente Jan; Havekes Louis M; Ramaekers Frans C S; Kuipers Folkert; Rensen Patrick C N; Mulder Monique
Human apolipoprotein C-I expression in mice impairs learning and memory functions.
Journal of lipid research 2008;49(4):856-69.
2008: de Haan Willeke; van der Hoogt Caroline C; Westerterp Marit; Hoekstra Menno; Dallinga-Thie Geesje M; Princen Hans M G; Romijn Johannes A; Jukema J Wouter; Havekes Louis M; Rensen Patrick C N
Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice.
Atherosclerosis 2008;197(1):57-63.
2008: Berbée Jimmy F P; Mooijaart Simon P; de Craen Anton J M; Havekes Louis M; van Heemst Diana; Rensen Patrick C N; Westendorp Rudi G J
Plasma apolipoprotein CI protects against mortality from infection in old age.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(2):122-6.
2008: van den Hoek A M; Teusink B; Voshol P J; Havekes L M; Romijn J A; Pijl H
Leptin deficiency per se dictates body composition and insulin action in ob/ob mice.
Journal of neuroendocrinology 2008;20(1):120-7.
2008: Parlevliet Edwin T; Heijboer Annemieke C; Schröder-van der Elst Janny P; Havekes Louis M; Romijn Johannes A; Pijl Hanno; Corssmit Eleonora P M
Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E142-7.
2007: van der Hoorn José W A; Kleemann Robert; Havekes Louis M; Kooistra Teake; Princen Hans M G; Jukema J Wouter
Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice.
Journal of hypertension 2007;25(12):2454-62.
2007: Westerterp Marit; Berbée Jimmy F P; Pires Nuno M M; van Mierlo Geertje J D; Kleemann Robert; Romijn Johannes A; Havekes Louis M; Rensen Patrick C N
Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice.
Circulation 2007;116(19):2173-81.
2007: Hu L; Bovenschen N; Havekes L M; van Vlijmen B J M; Tamsma J T
Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein.
Journal of thrombosis and haemostasis : JTH 2007;5(11):2301-4.
2007: Mulder Monique; Koopmans Guido; Wassink Guido; Al Mansouri Ghais; Simard Marie-Lune; Havekes Louis M; Prickaerts Jos; Blokland Arjan
LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus.
Neuroscience research 2007;59(3):251-6.
2007: Westerterp Marit; Van Eck Miranda; de Haan Willeke; Offerman Erik H; Van Berkel Theo J C; Havekes Louis M; Rensen Patrick C N
Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages.
Atherosclerosis 2007;195(1):e9-16.
2007: van Ginneken V; Verhey E; Poelmann R; Ramakers R; van Dijk K Willems; Ham Lisanne; Voshol P; Havekes L; Van Eck M; van der Greef J
Metabolomics (liver and blood profiling) in a mouse model in response to fasting: a study of hepatic steatosis.
Biochimica et biophysica acta 2007;1771(10):1263-70.
2007: Alkemade Fanneke E; Gittenberger-de Groot Adriana C; Schiel Anja E; VanMunsteren J Conny; Hogers Bianca; van Vliet Leontien S J; Poelmann Robert E; Havekes Louis M; Willems van Dijk Ko; DeRuiter Marco C
Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2228-35.
2007: Moen Corina J A; Tholens Aart P; Voshol Peter J; de Haan Willeke; Havekes Louis M; Gargalovic Peter; Lusis Aldons J; van Dyk Ko Willems; Frants Rune R; Hofker Marten H; Rensen Patrick C N
The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.
Journal of lipid research 2007;48(10):2182-92.
2007: van der Hoogt Caroline C; de Haan Willeke; Westerterp Marit; Hoekstra Menno; Dallinga-Thie Geesje M; Romijn Johannes A; Princen Hans M G; Jukema J Wouter; Havekes Louis M; Rensen Patrick C N
Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression.
Journal of lipid research 2007;48(8):1763-71.
2007: Henneman Peter; Schaap Frank G; Havekes Louis M; Rensen Patrick C N; Frants Rune R; van Tol Arie; Hattori Hiroaki; Smelt August H M; van Dijk Ko Willems
Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism.
Atherosclerosis 2007;193(1):129-34.
2007: Westerterp Marit; Berbée Jimmy F P; Delsing Dianne J M; Jong Miek C; Gijbels Marion J J; Dahlmans Vivian E H; Offerman Erik H; Romijn Johannes A; Havekes Louis M; Rensen Patrick C N
Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.
Journal of lipid research 2007;48(6):1353-61.
2007: Ferreira Valérie; van Dijk Ko Willems; Groen Albert K; Vos Rogier M; van der Kaa Jos; Gijbels Marion J J; Havekes Louis M; Pannekoek Hans
Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation.
Atherosclerosis 2007;192(2):283-90.
2007: Krom Yvonne D; Pires Nuno M M; Jukema J Wouter; de Vries Margreet R; Frants Rune R; Havekes Louis M; van Dijk Ko Willems; Quax Paul H A
Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists.
Cardiovascular research 2007;73(1):217-26.
2007: Gautier Thomas; Tietge Uwe J F; Boverhof Renze; Perton Frank G; Le Guern Naig; Masson David; Rensen Patrick C N; Havekes Louis M; Lagrost Laurent; Kuipers Folkert
Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.
Journal of lipid research 2007;48(1):30-40.
2007: van den Hoek Anita M; Heijboer Annemieke C; Voshol Peter J; Havekes Louis M; Romijn Johannes A; Corssmit Eleonora P M; Pijl Hanno
Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E238-45.
2006: Heijboer A C; Pijl H; Van den Hoek A M; Havekes L M; Romijn J A; Corssmit E P M
Gut-brain axis: regulation of glucose metabolism.
Journal of neuroendocrinology 2006;18(12):883-94.
2006: Hu L; Boesten L S M; May P; Herz J; Bovenschen N; Huisman M V; Berbée J F P; Havekes L M; van Vlijmen B J M; Tamsma J T
Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2710-5.
2006: Korsheninnikova E; van der Zon G C M; Voshol P J; Janssen G M; Havekes L M; Grefhorst A; Kuipers F; Reijngoud D-J; Romijn J A; Ouwens D M; Maassen J A
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.
Diabetologia 2006;49(12):3049-57.
2006: den Boer Marion A M; Voshol Peter J; Kuipers Folkert; Romijn Johannes A; Havekes Louis M
Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1360-4.
2006: Boesten L S M; Zadelaar S M; De Clercq S; Francoz S; van Nieuwkoop A; Biessen E A L; Hofmann F; Feil S; Feil R; Jochemsen A G; Zurcher C; Havekes L M; van Vlijmen B J M; Marine J-C
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death.
Cell death and differentiation 2006;13(12):2089-98.
2006: Westerterp Marit; van der Hoogt Caroline C; de Haan Willeke; Offerman Erik H; Dallinga-Thie Geesje M; Jukema J Wouter; Havekes Louis M; Rensen Patrick C N
Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2552-9.
2006: Zadelaar A Susanne M; Boesten Lianne S M; Jukema J Wouter; van Vlijmen Bart J M; Kooistra Teake; Emeis Jef J; Lundholm Erik; Camejo German; Havekes Louis M
Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2560-6.
2006: Berbée Jimmy F P; van der Hoogt Caroline C; Kleemann Robert; Schippers Emile F; Kitchens Richard L; van Dissel Jaap T; Bakker-Woudenberg Irma A J M; Havekes Louis M; Rensen Patrick C N
Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2162-4.
2006: den Boer Marion A M; Voshol Peter J; Schröder-van der Elst Janny P; Korsheninnikova Elena; Ouwens D Margriet; Kuipers Folkert; Havekes Louis M; Romijn Johannes A
Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice.
Endocrinology 2006;147(10):4553-8.
2006: Duivenvoorden Ilse; Voshol Peter J; Rensen Patrick C N; van Duyvenvoorde Wim; Romijn Johannes A; Emeis Jef J; Havekes Louis M; Nieuwenhuizen Willem F
Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice.
The American journal of clinical nutrition 2006;84(2):312-21.
2006: Mooijaart Simon P; Berbée Jimmy F P; van Heemst Diana; Havekes Louis M; de Craen Anton J M; Slagboom P Eline; Rensen Patrick C N; Westendorp Rudi G J
ApoE plasma levels and risk of cardiovascular mortality in old age.
PLoS medicine 2006;3(6):e176.
2006: Westerterp Marit; de Haan Willeke; Berbée Jimmy F P; Havekes Louis M; Rensen Patrick C N
Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL.
Journal of lipid research 2006;47(6):1203-11.
2006: Emile Gras J C; Verkuijlen Paul; Frants Rune R; Havekes Louis M; van Berkel Theo J C; Biessen Erik A L; van Dijk K Willems
Specific and efficient targeting of adenovirus vectors to macrophages: application of a fusion protein between an adenovirus-binding fragment and avidin, linked to a biotinylated oligonucleotide.
The journal of gene medicine 2006;8(6):668-78.
2006: Boesten Lianne S M; Zadelaar A Susanne M; van Nieuwkoop Anita; Hu Lihui; Jonkers Jos; van de Water Bob; Gijbels Marion J J; van der Made Ingeborg; de Winther Menno P J; Havekes Louis M; van Vlijmen Bart J M
Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):953-5.
2006: Rensen Patrick C N; Havekes Louis M
Cholesteryl ester transfer protein inhibition: effect on reverse cholesterol transport?
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):681-4.
2006: Heijboer A C; van den Hoek A M; Parlevliet E T; Havekes L M; Romijn J A; Pijl H; Corssmit E P M
Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice.
Diabetologia 2006;49(4):732-8.
2006: van der Hoogt Caroline C; Berbée Jimmy F P; Espirito Santo Sonia M S; Gerritsen Gery; Krom Yvonne D; van der Zee André; Havekes Louis M; van Dijk Ko Willems; Rensen Patrick C N
Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.
Biochimica et biophysica acta 2006;1761(2):213-20.
2006: Zadelaar Susanne M; Boesten Lianne S M; Pires Nuno M M; van Nieuwkoop Anita; Biessen Erik A L; Jukema Wouter; Havekes Louis M; van Vlijmen Bart J M; Willems van Dijk Ko
Local Cre-mediated gene recombination in vascular smooth muscle cells in mice.
Transgenic research 2006;15(1):31-6.
2006: Trion Astrid; de Maat Moniek; Jukema Wouter; Maas Annemarie; Offerman Erik; Havekes Louis; Szalai Alex; van der Laarse Arnoud; Princen Hans; Emeis Jef
Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice.
Journal of cardiovascular pharmacology 2006;47(1):89-95.
2006: den Boer Marion A M; Berbée Jimmy F P; Reiss Peter; van der Valk Marc; Voshol Peter J; Kuipers Folkert; Havekes Louis M; Rensen Patrick C N; Romijn Johannes A
Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(1):124-9.
2005: Monraats Pascalle S; Pires Nuno M M; Schepers Abbey; Agema Willem R P; Boesten Lianne S M; de Vries Margreet R; Zwinderman Aeilko H; de Maat Moniek P M; Doevendans Pieter A F M; de Winter Robbert J; Tio René A; Waltenberger Johannes; 't Hart Leen M; Frants Rune R; Quax Paul H A; van Vlijmen Bart J M; Havekes Louis M; van der Laarse Arnoud; van der Wall Ernst E; Jukema J Wouter
Tumor necrosis factor-alpha plays an important role in restenosis development.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):1998-2004.
2005: Rensen Patrick C N; van Dijk Ko Willems; Havekes Louis M
Apolipoprotein AV: low concentration, high impact.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2445-7.
2005: Krom Y D; Gras J C E; Frants R R; Havekes L M; van Berkel T J; Biessen E A L; van Dijk K Willems
Efficient targeting of adenoviral vectors to integrin positive vascular cells utilizing a CAR-cyclic RGD linker protein.
Biochemical and biophysical research communications 2005;338(2):847-54.
2005: Heijboer A C; Voshol P J; Donga E; van Eden C G; Havekes L M; Romijn J A; Pijl H; Corssmit E P M
High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice.
Peptides 2005;26(12):2554-8.
2005: Zadelaar A Susanne M; von der Thüsen Jan H; Boesten Lianne S M; Hoeben Rob C; Kockx Mark M; Versnel Marjan A; van Berkel Theo J C; Havekes Louis M; Biessen Erik A L; van Vlijmen Bart J M
Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer.
Atherosclerosis 2005;183(2):244-50.
2005: Grefhorst Aldo; van Dijk Theo H; Hammer Anke; van der Sluijs Fjodor H; Havinga Rick; Havekes Louis M; Romijn Johannes A; Groot Pieter H; Reijngoud Dirk-Jan; Kuipers Folkert
Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.
American journal of physiology. Endocrinology and metabolism 2005;289(5):E829-38.
2005: Kreeft Arja J; Moen Corina J A; Porter Gordon; Kasanmoentalib Soemini; Sverdlov Ronit; van Gorp Patrick J; Havekes Louis M; Frants Rune R; Hofker Marten H
Genomic analysis of the response of mouse models to high-fat feeding shows a major role of nuclear receptors in the simultaneous regulation of lipid and inflammatory genes.
Atherosclerosis 2005;182(2):249-57.
2005: Goudriaan Jeltje R; den Boer Marion A M; Rensen Patrick C N; Febbraio Maria; Kuipers Folkert; Romijn Johannes A; Havekes Louis M; Voshol Peter J
CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance.
Journal of lipid research 2005;46(10):2175-81.
2005: Grefhorst Aldo; Hoekstra Jildou; Derks Terry G J; Ouwens D Margriet; Baller Julius F W; Havinga Rick; Havekes Louis M; Romijn Johannes A; Kuipers Folkert
Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(3):G592-8.
2005: Pires Nuno M M; van der Hoeven Barend L; de Vries Margreet R; Havekes Louis M; van Vlijmen Bart J; Hennink Wim E; Quax Paul H A; Jukema J Wouter
Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff.
Biomaterials 2005;26(26):5386-94.
2005: Heijboer A C; van den Hoek A M; Pijl H; Voshol P J; Havekes L M; Romijn J A; Corssmit E P M
Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice.
Diabetologia 2005;48(8):1621-6.
2005: Trion A; de Maat M P M; Jukema J W; van der Laarse A; Maas M C; Offerman E H; Havekes L M; Szalai A J; Princen H M G; Emeis J J
No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1635-40.
2005: Bovenschen Niels; Mertens Koen; Hu Lihui; Havekes Louis M; van Vlijmen Bart J M
LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.
Blood 2005;106(3):906-12.
2005: Gerritsen Gery; Rensen Patrick C N; Kypreos Kyriakos E; Zannis Vassilis I; Havekes Louis M; Willems van Dijk Ko
ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression.
Journal of lipid research 2005;46(7):1466-73.
2005: Bovenschen N; Rijken D C; Havekes L M; van Vlijmen B J M; Mertens K
The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor.
Journal of thrombosis and haemostasis : JTH 2005;3(6):1257-65.
2005: Espirito Santo Sonia M S; Rensen Patrick C N; Goudriaan Jeltje R; Bensadoun André; Bovenschen Niels; Voshol Peter J; Havekes Louis M; van Vlijmen Bart J M
Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice.
Journal of lipid research 2005;46(6):1097-102.
2005: de Roos Baukje; Duivenvoorden Ilse; Rucklidge Garry; Reid Martin; Ross Karen; Lamers Robert-Jan A N; Voshol Peter J; Havekes Louis M; Teusink Bas
Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: combining liver proteomics with physiological data.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(7):813-5.
2005: Duivenvoorden Ilse; Teusink Bas; Rensen Patrick C N; Kuipers Folkert; Romijn Johannes A; Havekes Louis M; Voshol Peter J
Acute inhibition of hepatic beta-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity.
Journal of lipid research 2005;46(5):988-93.
2005: Boesten Lianne S M; Zadelaar A Susanne M; van Nieuwkoop Anita; Gijbels Marion J J; de Winther Menno P J; Havekes Louis M; van Vlijmen Bart J M
Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic mice.
Cardiovascular research 2005;66(1):179-85.
2005: Wang Mei; Lamers Robert-Jan A N; Korthout Henrie A A J; van Nesselrooij Joop H J; Witkamp Renger F; van der Heijden Rob; Voshol Peter J; Havekes Louis M; Verpoorte Rob; van der Greef Jan
Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology.
Phytotherapy research : PTR 2005;19(3):173-82.
2005: Duivenvoorden Ilse; Teusink Bas; Rensen Patrick C; Romijn Johannes A; Havekes Louis M; Voshol Peter J
Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.
Diabetes 2005;54(3):664-71.
2005: Yan Xuedong; Kuipers Folkert; Havekes Louis M; Havinga Rick; Dontje Bert; Poelstra Klaas; Scherphof Gerrit L; Kamps Jan A A M
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse.
Biochemical and biophysical research communications 2005;328(1):57-62.
2005: Heijboer Annemieke C; Donga Esther; Voshol Peter J; Dang Zhi-Chao; Havekes Louis M; Romijn Johannes A; Corssmit Eleonora P M
Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice.
Journal of lipid research 2005;46(3):582-8.
2005: Berbée Jimmy F P; van der Hoogt Caroline C; Sundararaman Deepa; Havekes Louis M; Rensen Patrick C N
Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL.
Journal of lipid research 2005;46(2):297-306.
2005: Kypreos Kyriakos E; van Dijk Ko W; Havekes Louis M; Zannis Vassilis I
Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia.
The Journal of biological chemistry 2005;280(8):6276-84.
2005: Delsing Dianne J M; Post Sabine M; Groenendijk Martine; Solaas Karianne; van der Boom Hans; van Duyvenvoorde Wim; de Wit Elly C M; Bloks Vincent W; Kuipers Folkert; Havekes Louis M; Princen Hans M G
Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-leiden mice.
Journal of cardiovascular pharmacology 2005;45(1):53-60.
2005: Gautier Thomas; Masson David; Jong Miek C; Pais de Barros Jean-Paul; Duverneuil Linda; Le Guern Naig; Deckert Valérie; Dumont Laure; Bataille Amandine; Zak Zoulika; Jiang Xian-Cheng; Havekes Louis M; Lagrost Laurent
Apolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic mice.
The Biochemical journal 2005;385(Pt 1):189-95.
2005: Berbée Jimmy F P; Havekes Louis M; Rensen Patrick C N
Apolipoproteins modulate the inflammatory response to lipopolysaccharide.
Journal of endotoxin research 2005;11(2):97-103.
2004: Espirito Santo Sonia M S; van Vlijmen Bart J M; van Duyvenvoorde Wim; Offerman Erik H; Havekes Louis M; Arnault Ingrid; Auger Jacques; Princen Hans M G
Absence of an atheroprotective effect of the garlic powder printanor in APOE*3-Leiden transgenic mice.
Atherosclerosis 2004;177(2):291-7.
2004: van den Hoek Anita M; Voshol Peter J; Karnekamp Barbara N; Buijs Ruud M; Romijn Johannes A; Havekes Louis M; Pijl Hanno
Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin.
Diabetes 2004;53(10):2529-34.
2004: Bovenschen Niels; van Dijk Ko Willems; Havekes Louis M; Mertens Koen; van Vlijmen Bart J M
Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.
British journal of haematology 2004;126(5):722-5.
2004: van den Hoek Anita M; Heijboer Annemieke C; Corssmit Eleonora P M; Voshol Peter J; Romijn Johannes A; Havekes Louis M; Pijl Hanno
PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet.
Diabetes 2004;53(8):1949-52.
2004: Goudriaan Jeltje R; Espirito Santo Sonia M S; Voshol Peter J; Teusink Bas; van Dijk Ko Willems; van Vlijmen Bart J M; Romijn Johannes A; Havekes Louis M; Rensen Patrick C N
The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis.
Journal of lipid research 2004;45(8):1475-81.
2004: Patsouris David; Mandard Stéphane; Voshol Peter J; Escher Pascal; Tan Nguan Soon; Havekes Louis M; Koenig Wolfgang; März Winfried; Tafuri Sherrie; Wahli Walter; Müller Michael; Kersten Sander
PPARalpha governs glycerol metabolism.
The Journal of clinical investigation 2004;114(1):94-103.
2004: Schaap Frank G; Rensen Patrick C N; Voshol Peter J; Vrins Carlos; van der Vliet Hendrik N; Chamuleau Robert A F M; Havekes Louis M; Groen Albert K; van Dijk Ko Willems
ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis.
The Journal of biological chemistry 2004;279(27):27941-7.
2004: Mulder Monique; Jansen Paula J; Janssen Ben J A; van de Berg Wilma D J; van der Boom Hans; Havekes Louis M; de Kloet Ron E; Ramaekers Frans C S; Blokland Arjan
Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus.
Neurobiology of disease 2004;16(1):212-9.
2004: Espirito Santo Sonia M S; van Vlijmen Bart J M; Buytenhek Rien; van Duyvenvoorde Wim; Havekes Louis M; Arnault Ingrid; Auger Jacques; Princen Hans M G
Well-characterized garlic-derived materials are not hypolipidemic in APOE*3-Leiden transgenic mice.
The Journal of nutrition 2004;134(6):1500-3.
2004: van Dijk Ko Willems; Rensen Patrick C N; Voshol Peter J; Havekes Louis M
The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism?
Current opinion in lipidology 2004;15(3):239-46.
2004: Espirito Santo Sonia M S; Pires Nuno M M; Boesten Lianne S M; Gerritsen Gery; Bovenschen Niels; van Dijk Ko Willems; Jukema J Wouter; Princen Hans M G; Bensadoun André; Li Wei-Ping; Herz Joachim; Havekes Louis M; van Vlijmen Bart J M
Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol.
Blood 2004;103(10):3777-82.
2004: Mensenkamp Arjen R; Van Luyn Marja J A; Havinga Rick; Teusink Bas; Waterman Ian J; Mann Christopher J; Elzinga Baukje M; Verkade Henkjan J; Zammit Victor A; Havekes Louis M; Shoulders Carol C; Kuipers Folkert
The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice.
Journal of hepatology 2004;40(4):599-606.
2004: den Boer M; Voshol P J; Kuipers F; Havekes L M; Romijn J A
Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):644-9.
2004: Muurling Martin; van den Hoek Anita M; Mensink Ronald P; Pijl Hanno; Romijn Johannes A; Havekes Louis M; Voshol Peter J
Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance.
Journal of lipid research 2004;45(1):9-16.
2004: Davidov Eugene; Clish Clary B; Oresic Matej; Meys Michael; Stochaj Wayne; Snell Philip; Lavine Gary; Londo Thomas R; Adourian Aram; Zhang Xiang; Johnston Mark; Morel Nicole; Marple Edward W; Plasterer Thomas N; Neumann Eric; Verheij Elwin; Vogels Jack T W E; Havekes Louis M; van der Greef Jan; Naylor Stephen
Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model.
Omics : a journal of integrative biology 2004;8(4):267-88.
2004: Oresic Matej; Clish Clary B; Davidov Eugene J; Verheij Elwin; Vogels Jack; Havekes Louis M; Neumann Eric; Adourian Aram; Naylor Stephen; van der Greef Jan; Plasterer Thomas
Phenotype characterisation using integrated gene transcript, protein and metabolite profiling.
Applied bioinformatics 2004;3(4):205-17.
2004: Clish Clary B; Davidov Eugene; Oresic Matej; Plasterer Thomas N; Lavine Gary; Londo Tom; Meys Michael; Snell Philip; Stochaj Wayne; Adourian Aram; Zhang Xiang; Morel Nicole; Neumann Eric; Verheij Elwin; Vogels Jack T W E; Havekes Louis M; Afeyan Noubar; Regnier Fred; van der Greef Jan; Naylor Stephen
Integrative biological analysis of the APOE*3-leiden transgenic mouse.
Omics : a journal of integrative biology 2004;8(1):3-13.
2003: Goudriaan Jeltje R; Dahlmans Vivian E H; Teusink Bas; Ouwens D Margriet; Febbraio Maria; Maassen J Anton; Romijn Johannes A; Havekes Louis M; Voshol Peter J
CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice.
Journal of lipid research 2003;44(12):2270-7.
2003: Fliers E; Kreier F; Voshol P J; Havekes L M; Sauerwein H P; Kalsbeek A; Buijs R M; Romijn J A
White adipose tissue: getting nervous.
Journal of neuroendocrinology 2003;15(11):1005-10.
2003: Muurling Martin; Mensink Ronald P; Pijl Hanno; Romijn Johannes A; Havekes Louis M; Voshol Peter J
A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice.
The Journal of nutrition 2003;133(11):3350-5.
2003: Kleemann Robert; Princen Hans M G; Emeis Jef J; Jukema J Wouter; Fontijn Ruud D; Horrevoets Anton J G; Kooistra Teake; Havekes Louis M
Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin.
Circulation 2003;108(11):1368-74.
2003: Kypreos Kyriakos E; Li Xiaoping; van Dijk Ko Willems; Havekes Louis M; Zannis Vassilis I
Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype.
Biochemistry 2003;42(33):9841-53.
2003: Muurling Martin; Mensink Ronald P; Pijl Hanno; Romijn Johannes A; Havekes Louis M; Voshol Peter J
Rosiglitazone improves muscle insulin sensitivity, irrespective of increased triglyceride content, in ob/ob mice.
Metabolism: clinical and experimental 2003;52(8):1078-83.
2003: Voshol Peter J; Haemmerle Guenter; Ouwens D Margriet; Zimmermann Robert; Zechner Rudolf; Teusink Bas; Maassen J Antonie; Havekes Louis M; Romijn Johannes A
Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice.
Endocrinology 2003;144(8):3456-62.
2003: Delsing Dianne J M; Jukema J Wouter; van de Wiel Mark A; Emeis Jef J; van der Laarse Arnoud; Havekes Louis M; Princen Hans M G
Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice.
Journal of cardiovascular pharmacology 2003;42(1):63-70.
2003: Bovenschen Niels; Herz Joachim; Grimbergen Jos M; Lenting Peter J; Havekes Louis M; Mertens Koen; van Vlijmen Bart J M
Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency.
Blood 2003;101(10):3933-9.
2003: Teusink Bas; Voshol Peter J; Dahlmans Vivian E H; Rensen Patrick C N; Pijl Hanno; Romijn Johannes A; Havekes Louis M
Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake.
Diabetes 2003;52(3):614-20.
2003: Gerritsen Gery; Kypreos Kyriakos E; van der Zee André; Teusink Bas; Zannis Vassilis I; Havekes Louis M; van Dijk Ko Willems
Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.
Journal of lipid research 2003;44(2):408-14.
2003: van de Poll Sweder W E; Delsing Dianne J M; Wouter Jukema J; Princen Hans M G; Havekes Louis M; Puppels Gerwin J; van der Laarse Arnoud
Effects of amlodipine, atorvastatin and combination of both on advanced atherosclerotic plaque in APOE*3-Leiden transgenic mice.
Journal of molecular and cellular cardiology 2003;35(1):109-18.
2002: Kreier Felix; Fliers Eric; Voshol Peter J; Van Eden Corbert G; Havekes Louis M; Kalsbeek Andries; Van Heijningen Caroline L; Sluiter Arja A; Mettenleiter Thomas C; Romijn Johannes A; Sauerwein Hans P; Buijs Ruud M
Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications.
The Journal of clinical investigation 2002;110(9):1243-50.
2002: Goudriaan Jeltje R; Dahlmans Vivian E H; Febbraio Maria; Teusink Bas; Romijn Johannes A; Havekes Louis M; Voshol Peter J
Intestinal lipid absorption is not affected in CD36 deficient mice.
Molecular and cellular biochemistry 2002;239(1-2):199-202.
2002: Lardenoye J H P; De Vries M R; Grimbergen J M; Havekes L M; Knaapen M W M; Kockx M M; van Hinsbergh V W M; van Bockel J H; Quax P H A
Inhibition of accelerated atherosclerosis in vein grafts by placement of external stent in apoE*3-Leiden transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1433-8.
2002: van Dam M; Zwart M; de Beer F; Smelt A H M; Prins M H; Trip M D; Havekes L M; Lansberg P J; Kastelein J J P
Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia.
Heart (British Cardiac Society) 2002;88(3):234-8.
2002: van de Poll Sweder W E; Delsing Dianne J M; Jukema J Wouter; Princen Hans M G; Havekes Louis M; Puppels Gerwin J; van der Laarse Arnoud
Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice.
Atherosclerosis 2002;164(1):65-71.
2002: Grefhorst Aldo; Elzinga Baukje M; Voshol Peter J; Plösch Torsten; Kok Tineke; Bloks Vincent W; van der Sluijs Fjodor H; Havekes Louis M; Romijn Johannes A; Verkade Henkjan J; Kuipers Folkert
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles.
The Journal of biological chemistry 2002;277(37):34182-90.
2002: Gautier Thomas; Masson David; Jong Miek C; Duverneuil Linda; Le Guern Naig; Deckert Valérie; Pais de Barros Jean-Paul; Dumont Laure; Bataille Amandine; Zak Zoulika; Jiang Xian-Cheng; Tall Alan R; Havekes Louis M; Lagrost Laurent
Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice.
The Journal of biological chemistry 2002;277(35):31354-63.
2002: Muurling Martin; Jong Miek C; Mensink Ronald P; Hornstra Gerard; Dahlmans Vivian E H; Pijl Hanno; Voshol Peter J; Havekes Louis M
A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice.
Metabolism: clinical and experimental 2002;51(6):695-701.
2002: Draijer Richard; Volger Oscar L; Dahlmans Vivian E H; de Wit Elly C M; Havekes Louis M; Princen Hans M G
HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice.
Biochemical pharmacology 2002;63(9):1755-61.
2002: Tacken Paul J; Delsing Dianne J M; Gijbels Marion J J; Quax Paul H A; Havekes Louis M; Hofker Marten H; van Dijk Ko Willems
VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area.
Atherosclerosis 2002;162(1):103-10.
2002: von der Thüsen Jan H; van Vlijmen Bart J M; Hoeben Rob C; Kockx Mark M; Havekes Louis M; van Berkel Theo J C; Biessen Erik A L
Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53.
Circulation 2002;105(17):2064-70.
2002: de Beer F; Smelt A H M; van Vark L C; Hoogerbrugge N; Havekes L M; Gevers Leuven J A
The effect of tibolone on the lipoprotein profile of postmenopausal women with type III hyperlipoproteinemia.
Journal of internal medicine 2002;251(2):148-55.
2002: de Beer Femke; Stalenhoef Anton F H; Hoogerbrugge Nicoline; Kastelein John J P; Gevers Leuven Jan A; van Duijn Cornelia M; Havekes Louis M; Smelt Augustinus H M
Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):294-9.
2001: Kreeft A J; Moen C J; Hofker M H; Frants R R; Vreugdenhil E; Gijbels M J; Havekes L M; Datson N A
Identification of differentially regulated genes in mildly hyperlipidemic ApoE3-Leiden mice by use of serial analysis of gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1984-90.
2001: Mensenkamp A R; Havekes L M; Romijn J A; Kuipers F
Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E.
Journal of hepatology 2001;35(6):816-22.
2001: Jong M C; Voshol P J; Muurling M; Dahlmans V E; Romijn J A; Pijl H; Havekes L M
Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1.
Diabetes 2001;50(12):2779-85.
2001: Voshol P J; Jong M C; Dahlmans V E; Kratky D; Levak-Frank S; Zechner R; Romijn J A; Havekes L M
In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake.
Diabetes 2001;50(11):2585-90.
2001: Teusink B; Mensenkamp A R; van der Boom H; Kuipers F; van Dijk K W; Havekes L M
Stimulation of the in vivo production of very low density lipoproteins by apolipoprotein E is independent of the presence of the low density lipoprotein receptor.
The Journal of biological chemistry 2001;276(44):40693-7.
2001: van De Poll S W; Römer T J; Volger O L; Delsing D J; Bakker Schut T C; Princen H M; Havekes L M; Jukema J W; van Der Laarse A; Puppels G J
Raman spectroscopic evaluation of the effects of diet and lipid-lowering therapy on atherosclerotic plaque development in mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1630-5.
2001: Jong M C; Rensen P C; Dahlmans V E; van der Boom H; van Berkel T J; Havekes L M
Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice.
Journal of lipid research 2001;42(10):1578-85.
2001: Goudriaan J R; Tacken P J; Dahlmans V E; Gijbels M J; van Dijk K W; Havekes L M; Jong M C
Protection from obesity in mice lacking the VLDL receptor.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1488-93.
2001: Mensenkamp A R; Teusink B; Baller J F; Wolters H; Havinga R; van Dijk K W; Havekes L M; Kuipers F
Mice expressing only the mutant APOE3Leiden gene show impaired VLDL secretion.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(8):1366-72.
2001: Volger O L; Mensink R P; Plat J; Hornstra G; Havekes L M; Princen H M
Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE*3-Leiden transgenic mice.
Atherosclerosis 2001;157(2):375-81.
2001: Mulder M; Blokland A; van den Berg D J; Schulten H; Bakker A H; Terwel D; Honig W; de Kloet E R; Havekes L M; Steinbusch H W; de Lange E C
Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging.
Laboratory investigation; a journal of technical methods and pathology 2001;81(7):953-60.
2001: Kypreos K E; Teusink B; Van Dijk K W; Havekes L M; Zannis V I
Analysis of the structure and function relationship of the human apolipoprotein E in vivo, using adenovirus-mediated gene transfer.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1598-600.
2001: Tacken P J; van der Zee A; Beumer T L; Florijn R J; Gijpels M J; Havekes L M; Frants R R; van Dijk K W; Hofker M H
Effective generation of very low density lipoprotein receptor transgenic mice by overlapping genomic DNA fragments: high testis expression and disturbed spermatogenesis.
Transgenic research 2001;10(3):211-21.
2001: Volger O L; van der Boom H; de Wit E C; van Duyvenvoorde W; Hornstra G; Plat J; Havekes L M; Mensink R P; Princen H M
Dietary plant stanol esters reduce VLDL cholesterol secretion and bile saturation in apolipoprotein E*3-Leiden transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(6):1046-52.
2001: Tacken P J; Hofker M H; Havekes L M; van Dijk K W
Living up to a name: the role of the VLDL receptor in lipid metabolism.
Current opinion in lipidology 2001;12(3):275-9.
2001: Kypreos K E; van Dijk K W; van Der Zee A; Havekes L M; Zannis V I
Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.
The Journal of biological chemistry 2001;276(23):19778-86.
2001: Kypreos K E; Morani P; van Dijk K W; Havekes L M; Zannis V I
The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.
Biochemistry 2001;40(20):6027-35.
2001: Koopmans S J; Jong M C; Que I; Dahlmans V E; Pijl H; Radder J K; Frölich M; Havekes L M
Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1.
Diabetologia 2001;44(4):437-43.
2001: van Vlijmen B J; Gerritsen G; Franken A L; Boesten L S; Kockx M M; Gijbels M J; Vierboom M P; van Eck M; van De Water B; van Berkel T J; Havekes L M
Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice.
Circulation research 2001;88(8):780-6.
2001: Delsing D J; Offerman E H; van Duyvenvoorde W; van Der Boom H; de Wit E C; Gijbels M J; van Der Laarse A; Jukema J W; Havekes L M; Princen H M
Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice.
Circulation 2001;103(13):1778-86.
2000: de Man F H; de Beer F; van der Laarse A; Jansen H; Leuven J A; Souverijn J H; Vroom T F; Schoormans S C; Fruchart J C; Havekes L M; Smelt A H
The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to lipolysis or LDL receptor binding.
Atherosclerosis 2000;153(2):363-71.
2000: Van Eck M; De Winther M P; Herijgers N; Havekes L M; Hofker M H; Groot P H; Van Berkel T J
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2600-6.
2000: Tacken P J; Teusink B; Jong M C; Harats D; Havekes L M; van Dijk K W; Hofker M H
LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice.
Journal of lipid research 2000;41(12):2055-62.
2000: Herijgers N; de Winther M P; Van Eck M; Havekes L M; Hofker M H; Hoogerbrugge P M; Van Berkel T J
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.
Journal of lipid research 2000;41(9):1402-9.
2000: Mensenkamp A R; van Luyn M J; van Goor H; Bloks V; Apostel F; Greeve J; Hofker M H; Jong M C; van Vlijmen B J; Havekes L M; Kuipers F
Hepatic lipid accumulation, altered very low density lipoprotein formation and apolipoprotein E deposition in apolipoprotein E3-Leiden transgenic mice.
Journal of hepatology 2000;33(2):189-98.
2000: Lardenoye J H; Delsing D J; de Vries M R; Deckers M M; Princen H M; Havekes L M; van Hinsbergh V W; van Bockel J H; Quax P H
Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3Leiden transgenic mice.
Circulation research 2000;87(3):248-53.
2000: de Beer F; van Dijk K W; Jong M C; van Vark L C; van der Zee A; Hofker M H; Fallaux F J; Hoeben R C; Smelt A H; Havekes L M
Apolipoprotein E2 (Lys146-->Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1800-6.
2000: Post S M; de Roos B; Vermeulen M; Afman L; Jong M C; Dahlmans V E; Havekes L M; Stellaard F; Katan M B; Princen H M
Cafestol increases serum cholesterol levels in apolipoprotein E*3-Leiden transgenic mice by suppression of bile acid synthesis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1551-6.
2000: Tacken P J; Beer F D; Vark L C; Havekes L M; Hofker M H; Willems Van Dijk K
Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E.
The Biochemical journal 2000;347(Pt 2):357-61.
2000: Sijbrands E J; Westendorp R G; Paola Lombardi M; Havekes L M; Frants R R; Kastelein J J; Smelt A H
Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia.
Atherosclerosis 2000;149(2):421-5.
2000: Rensen P C; Jong M C; van Vark L C; van der Boom H; Hendriks W L; van Berkel T J; Biessen E A; Havekes L M
Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis.
The Journal of biological chemistry 2000;275(12):8564-71.
2000: Lombardi M P; Redeker E J; Defesche J C; Kamerling S W; Trip M D; Mannens M M; Havekes L M; Kastelein J J
Molecular genetic testing for familial hypercholesterolemia: spectrum of LDL receptor gene mutations in The Netherlands.
Clinical genetics 2000;57(2):116-24.
2000: de Winther M P; van Dijk K W; Havekes L M; Hofker M H
Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):290-7.
2000: Jong M C; Hendriks W L; van Vark L C; Dahlmans V E; Groener J E; Havekes L M
Oxidized VLDL induces less triglyceride accumulation in J774 macrophages than native VLDL due to an impaired extracellular lipolysis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):144-51.
2000: Van Eck M; Herijgers N; Van Dijk K W; Havekes L M; Hofker M H; Groot P H; Van Berkel T J
Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158-->Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):119-27.
2000: De Winther M P; Gijbels M J; Van Dijk K W; Havekes L M; Hofker M H
Transgenic mouse models to study the role of the macrophage scavenger receptor class A in atherosclerosis.
International journal of tissue reactions 2000;22(2-3):85-91.
2000: Jong M C; Havekes L M
Insights into apolipoprotein C metabolism from transgenic and gene-targeted mice.
International journal of tissue reactions 2000;22(2-3):59-66.
2000: Willems Van Dijk K; Hofker M H; Havekes L M
Use of transgenic mice to study the role of apolipoprotein E in lipid metabolism and atherosclerosis.
International journal of tissue reactions 2000;22(2-3):49-58.
1999: van Dijk K W; van Vlijmen B J; de Winther M P; van 't Hof B; van der Zee A; van der Boom H; Havekes L M; Hofker M H
Hyperlipidemia of ApoE2(Arg(158)-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2945-51.
1999: Mensenkamp A R; Jong M C; van Goor H; van Luyn M J; Bloks V; Havinga R; Voshol P J; Hofker M H; van Dijk K W; Havekes L M; Kuipers F
Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver.
The Journal of biological chemistry 1999;274(50):35711-8.
1999: van Vlijmen B J; Rohlmann A; Page S T; Bensadoun A; Bos I S; van Berkel T J; Havekes L M; Herz J
An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins.
The Journal of biological chemistry 1999;274(49):35219-26.
1999: de Winther M P; van Dijk K W; van Vlijmen B J; Gijbels M J; Heus J J; Wijers E R; van den Bos A C; Breuer M; Frants R R; Havekes L M; Hofker M H
Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.
Atherosclerosis 1999;147(2):339-47.
1999: Sijbrands E J; Hoffer M J; Meinders A E; Havekes L M; Frants R R; Smelt A H; De Knijff P
Severe hyperlipidemia in apolipoprotein E2 homozygotes due to a combined effect of hyperinsulinemia and an SstI polymorphism.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2722-9.
1999: van Dijk K W; Hofker M H; Havekes L M
Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models.
Current atherosclerosis reports 1999;1(2):101-7.
1999: Lansink M; Jong M; Bijsterbosch M; Bekkers M; Toet K; Havekes L; Emeis J; Kooistra T
Increased clearance explains lower plasma levels of tissue-type plasminogen activator by estradiol: evidence for potently enhanced mannose receptor expression in mice.
Blood 1999;94(4):1330-6.
1999: de Winther M P; Gijbels M J; van Dijk K W; van Gorp P J; suzuki H; Kodama T; Frants R R; Havekes L M; Hofker M H
Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice.
Atherosclerosis 1999;144(2):315-21.
1999: de Beer F; Hendriks W L; van Vark L C; Kamerling S W; van Dijk K W; Hofker M H; Smelt A H; Havekes L M
Binding of beta-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas ApoE only modulates binding affinity.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):633-7.
1999: Jong M C; Hofker M H; Havekes L M
Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):472-84.
1999: Jong M C; van Dijk K W; Dahlmans V E; Van der Boom H; Kobayashi K; Oka K; Siest G; Chan L; Hofker M H; Havekes L M
Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor.
The Biochemical journal 1999;338 ( Pt 2)():281-7.
1999: van Dijk K W; van Vlijmen B J; van't Hof H B; van der Zee A; Santamarina-Fojo S; van Berkel T J; Havekes L M; Hofker M H
In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE.
Journal of lipid research 1999;40(2):336-44.
1999: Lutgens E; Daemen M; Kockx M; Doevendans P; Hofker M; Havekes L; Wellens H; de Muinck E D
Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage.
Circulation 1999;99(2):276-83.
1998: Jong M C; Dahlmans V E; Princen H M; Hofker M H; Havekes L M
Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice.
Atherosclerosis 1998;141 Suppl 1():S77-80.
1998: Hoffer M J; Sijbrands E J; De Man F H; Havekes L M; Smelt A H; Frants R R
Increased risk for endogenous hypertriglyceridaemia is associated with an apolipoprotein C3 haplotype specified by the SstI polymorphism.
European journal of clinical investigation 1998;28(10):807-12.
1998: Mulder M; Ravid R; Swaab D F; de Kloet E R; Haasdijk E D; Julk J; van der Boom J J; Havekes L M
Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4.
Alzheimer disease and associated disorders 1998;12(3):198-203.
1998: van Vlijmen B J; Mensink R P; van 't Hof H B; Offermans R F; Hofker M H; Havekes L M
Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice.
Journal of lipid research 1998;39(6):1181-8.
1998: Hoffer M J; Bredie S J; Snieder H; Reymer P W; Demacker P N; Havekes L M; Boomsma D I; Stalenhoef A F; Frants R R; Kastelein J J
Gender-related association between the -93T-->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia.
Atherosclerosis 1998;138(1):91-9.
1998: van Vlijmen B J; Pearce N J; Bergö M; Staels B; Yates J W; Gribble A D; Bond B C; Hofker M H; Havekes L M; Groot P H
Apolipoprotein E*3-Leiden transgenic mice as a test model for hypolipidaemic drugs.
Arzneimittel-Forschung 1998;48(4):396-402.
1998: Hofker M H; van Vlijmen B J; Havekes L M
Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis.
Atherosclerosis 1998;137(1):1-11.
1998: Hendriks W L; Van Vark L C; Schoonderwoerd K; Jansen H; Havekes L M
Not the mature 56 kDa lipoprotein lipase protein but a 37 kDa protein co-purifying with the lipase mediates the binding of low density lipoproteins to J774 macrophages.
The Biochemical journal 1998;330 ( Pt 2)():765-9.
1998: de Man F H; de Beer F; van de Laarse A; Smelt A H; Leuven J A; Havekes L M
Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase.
Atherosclerosis 1998;136(2):255-62.
1998: Sijbrands E J; Lombardi M P; Westendorp R G; Leuven J A; Meinders A E; Van der Laarse A; Frants R R; Havekes L M; Smelt A H
Similar response to simvastatin in patients heterozygous for familial hypercholesterolemia with mRNA negative and mRNA positive mutations.
Atherosclerosis 1998;136(2):247-54.
1998: van Dijk K W; van Vlijmen B J; van der Zee A; van't Hof B; van der Boom H; Kobayashi K; Chan L; Havekes L M; Hofker M H
Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(1):7-12.
1998: Jong M C; Gijbels M J; Dahlmans V E; Gorp P J; Koopman S J; Ponec M; Hofker M H; Havekes L M
Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1.
The Journal of clinical investigation 1998;101(1):145-52.
1998: Lombardi P; Sijbrands E J; Kamerling S; Smelt A H; Havekes L M
Identification of three new mutations of the low density lipoprotein receptor gene in Dutch familial hypercholesterolemic patients.
Human mutation 1998;Suppl 1():S172-4.
1997: de Man F H; de Beer F; van der Laarse A; Smelt A H; Havekes L M
Lipolysis of very low density lipoproteins by heparan sulfate proteoglycan-bound lipoprotein lipase.
Journal of lipid research 1997;38(12):2465-72.
1997: Jong M C; Dahlmans V E; Hofker M H; Havekes L M
Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner.
The Biochemical journal 1997;328 ( Pt 3)():745-50.
1997: Kuipers F; Jong M C; Lin Y; Eck M; Havinga R; Bloks V; Verkade H J; Hofker M H; Moshage H; Berkel T J; Vonk R J; Havekes L M
Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes.
The Journal of clinical investigation 1997;100(11):2915-22.
1997: Havekes L M; van Vlijmen B J; Jong M C; van Dijk K W; Hofker M H
Use of transgenic mice in lipoprotein metabolism and atherosclerosis research.
Prostaglandins, leukotrienes, and essential fatty acids 1997;57(4-5):463-6.
1997: Lombardi P; Defesche J C; Kamerling S W; Kastelein J J; Havekes L M
A novel mutation M-21V in exon 1 of the low density lipoprotein receptor gene causing familial hypercholesterolemia.
Clinical genetics 1997;51(6):430-1.
1997: Lombardi P; Defesche J C; Kamerling S W; Kastelein J J; Havekes L M
A novel V415A mutation in exon 9 of the low density lipoprotein receptor gene causing familial hypercholesterolemia.
Clinical genetics 1997;51(4):286-7.
1997: Hendriks W L; van der Sman-de Beer F; van Vlijmen B J; van Vark L C; Hofker M H; Havekes L M
Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):498-504.
1997: Jong M C; van Ree J H; Dahlmans V E; Frants R R; Hofker M H; Havekes L M
Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient mice.
The Biochemical journal 1997;321 ( Pt 2)():445-50.
1997: Lombardi P; Sijbrands E J; Kamerling S; Leuven J A; Havekes L M
The T705I mutation of the low density lipoprotein receptor gene (FH Paris-9) does not cause familial hypercholesterolemia.
Human genetics 1997;99(1):106-7.
1996: Lombardi P; Kamerling S W; Defesche J C; Kastelein J J; Havekes L M
Identification of a double mutation in the low-density lipoprotein receptor gene causing familial hypercholesterolemia.
Clinical genetics 1996;50(6):525-6.
1996: Jong M C; Dahlmans V E; van Gorp P J; van Dijk K W; Breuer M L; Hofker M H; Havekes L M
In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.
The Journal of clinical investigation 1996;98(10):2259-67.
1996: van Vlijmen B J; van Dijk K W; van't Hof H B; van Gorp P J; van der Zee A; van der Boom H; Breuer M L; Hofker M H; Havekes L M
In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice.
The Journal of biological chemistry 1996;271(48):30595-602.
1996: Sijbrands E J; Westendorp R G; Hoffer M J; Frants R R; Meinders A E; Souverijn J H; Gevers Leuven J A; Van der Laarse A; Havekes L M; Smelt A H
Effect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients.
Atherosclerosis 1996;126(2):197-205.
1996: Hoffer M J; Niththyananthan S; Naoumova R P; Kibirige M S; Frants R R; Havekes L M; Thompson G R
Apolipoprotein E1-Hammersmith (Lys146-->Asn;Arg147-->Trp), due to a dinucleotide substitution, is associated with early manifestation of dominant type III hyperlipoproteinaemia.
Atherosclerosis 1996;124(2):183-9.
1996: Jong M C; Dahlmans V E; van Gorp P J; Breuer M L; Mol M J; van der Zee A; Frants R R; Hofker M H; Havekes L M
Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(8):934-40.
1996: Groot P H; van Vlijmen B J; Benson G M; Hofker M H; Schiffelers R; Vidgeon-Hart M; Havekes L M
Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(8):926-33.
1996: van Vlijmen B J; van Ree J H; Frants R R; Hofker M H; Havekes L M
Elevated levels of chylomicron- and VLDL-remnants leads to atherosclerosis in apoE transgenic mice.
Zeitschrift für Gastroenterologie 1996;34 Suppl 3():113-5.
1996: Hendriks W L; van der Boom H; van Vark L C; Havekes L M
Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages.
The Biochemical journal 1996;314 ( Pt 2)():563-8.
1996: van Vlijmen B J; van 't Hof H B; Mol M J; van der Boom H; van der Zee A; Frants R R; Hofker M H; Havekes L M
Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice.
The Journal of clinical investigation 1996;97(5):1184-92.
1996: Hoffer M J; Bredie S J; Boomsma D I; Reymer P W; Kastelein J J; de Knijff P; Demacker P N; Stalenhoef A F; Havekes L M; Frants R R
The lipoprotein lipase (Asn291-->Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia.
Atherosclerosis 1996;119(2):159-67.
1996: Boomsma D I; Kempen H J; Gevers Leuven J A; Havekes L; de Knijff P; Frants R R
Genetic analysis of sex and generation differences in plasma lipid, lipoprotein, and apolipoprotein levels in adolescent twins and their parents.
Genetic epidemiology 1996;13(1):49-60.
1995: van Ree J H; van den Broek W J; Dahlmans V E; Wieringa B; Frants R R; Havekes L M; Hofker M H
Variability in cholesterol content in serum and aortic tissue in apolipoprotein E-deficient mice is comparable in inbred (129/Sv) and outbred (mixed 129/Sv and C57BL/6) mice.
Atherosclerosis 1995;118(1):165-7.
1995: van Dijk K W; Steketee K; Havekes L; Frants R; Hofker M
Genomic and cDNA cloning of a novel mouse lipoxygenase gene.
Biochimica et biophysica acta 1995;1259(1):4-8.
1995: van Ree J H; van den Broek W J; van der Zee A; Dahlmans V E; Wieringa B; Frants R R; Havekes L M; Hofker M H
Inactivation of Apoe and Apoc1 by two consecutive rounds of gene targeting: effects on mRNA expression levels of gene cluster members.
Human molecular genetics 1995;4(8):1403-9.
1995: Lombardi P; Sijbrands E J; van de Giessen K; Smelt A H; Kastelein J J; Frants R R; Havekes L M
Mutations in the low density lipoprotein receptor gene of familial hypercholesterolemic patients detected by denaturing gradient gel electrophoresis and direct sequencing.
Journal of lipid research 1995;36(4):860-7.
1995: van Ree J H; Hofker M H; van den Broek W J; van Deursen J M; van der Boom H; Frants R R; Wieringa B; Havekes L M
Increased response to cholesterol feeding in apolipoprotein C1-deficient mice.
The Biochemical journal 1995;305 ( Pt 3)():905-11.
1995: van Ree J H; Gijbels M J; van den Broek W J; Hofker M H; Havekes L M
Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding.
Atherosclerosis 1995;112(2):237-43.
1994: Zhao S P; Smelt A H; Van den Maagdenberg A M; Van Tol A; Vroom T F; Gevers Leuven J A; Frants R R; Havekes L M; Van der Laarse A; Van 't Hooft F M
Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2(Arg158-->Cys), E3-Leiden, and E2(Lys146-->Gln), and effects of treatment with simvastatin.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1705-16.
1994: van Ree J H; van den Broek W J; Dahlmans V E; Groot P H; Vidgeon-Hart M; Frants R R; Wieringa B; Havekes L M; Hofker M H
Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice.
Atherosclerosis 1994;111(1):25-37.
1994: Sijbrands E J; Westendorp R G; Hoffer M J; Havekes L M; Frants R R; Meinders A E; Frölich M; Smelt A H
Effect of insulin resistance, apoE2 allele, and smoking on combined hyperlipidemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(10):1576-80.
1994: de Knijff P; van den Maagdenberg A M; Boomsma D I; Stalenhoef A F; Smelt A H; Kastelein J J; Marais A D; Frants R R; Havekes L M
Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2 (Lys146-->Gln) Allele carriers.
The Journal of clinical investigation 1994;94(3):1252-62.
1994: van der Zee A; Stas L; Hilleker C; van Leuven F; van Dijk K W; Havekes L; Frants R; Hofker M
Genomic cloning of the mouse LDL receptor related protein/alpha 2-macroglobulin receptor gene.
Genomics 1994;23(1):256-9.
1994: Mulder M; van der Boom H; de Knijff P; Braam C; van den Maagdenberg A; Leuven J A; Havekes L M
Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lys146-->Gln) are inefficiently converted to cholesterol-rich lipoproteins.
Atherosclerosis 1994;108(2):183-92.
1994: van Eck M M; Hoffer M J; Havekes L M; Frants R R; Hofker M H
The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster.
Genomics 1994;21(1):110-5.
1994: van Vlijmen B J; van den Maagdenberg A M; Gijbels M J; van der Boom H; HogenEsch H; Frants R R; Hofker M H; Havekes L M
Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.
The Journal of clinical investigation 1994;93(4):1403-10.
1994: Zhao S P; Van den Maagdenberg A M; Vroom T F; Van 't Hooft F M; Gevers Leuvens J A; Havekes L M; Frants R R; Van der Laarse A; Smelt A H
Lipoprotein profiles in a family with two mutants of apolipoprotein E: possible association with hypertriglyceridaemia but not with dysbetalipoproteinaemia.
Clinical science (London, England : 1979) 1994;86(3):323-9.
1994: de Knijff P; van den Maagdenberg A M; Frants R R; Havekes L M
Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels.
Human mutation 1994;4(3):178-94.
1993: Lombardi P; Mulder M; van der Boom H; Frants R R; Havekes L M
Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment.
The Journal of biological chemistry 1993;268(35):26113-9.
1993: Lombardi P; Hoffer M J; Top B; de Wit E; Gevers Leuven J A; Frants R R; Havekes L M
An acceptor splice site mutation in intron 16 of the low density lipoprotein receptor gene leads to an elongated, internalization defective receptor.
Atherosclerosis 1993;104(1-2):117-28.
1993: Hoffer M J; van Eck M M; Havekes L M; Hofker M H; Frants R R
The mouse apolipoprotein C1 gene: structure and expression.
Genomics 1993;18(1):37-42.
1993: Hoffer M J; van Eck M M; Havekes L M; Hofker M H; Frants R R
Structure and expression of the mouse apolipoprotein C2 gene.
Genomics 1993;17(1):45-51.
1993: Top B; van der Zee A; Havekes L M; van 't Hooft F M; Frants R R
Identification of a splice-site mutation in the low density lipoprotein receptor gene by denaturing gradient gel electrophoresis.
Human genetics 1993;91(5):480-4.
1993: Mulder M; Lombardi P; Jansen H; van Berkel T J; Frants R R; Havekes L M
Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase.
The Journal of biological chemistry 1993;268(13):9369-75.
1993: van den Maagdenberg A M; Hofker M H; Krimpenfort P J; de Bruijn I; van Vlijmen B; van der Boom H; Havekes L M; Frants R R
Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.
The Journal of biological chemistry 1993;268(14):10540-5.
1993: Mulder M; Smelt A H; Zhao S P; Frants R R; Havekes L M
Treatment of E2E2 homozygous familial dysbetalipoproteinemic subjects with gemfibrozil does not enhance the binding of their d < 1.019 lipoprotein fraction to the low-density lipoprotein receptor.
Metabolism: clinical and experimental 1993;42(3):327-33.
1993: Hoffer M J; van Eck M M; Petrij F; van der Zee A; de Wit E; Meijer D; Grosveld G; Havekes L M; Hofker M H; Frants R R
The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.
Biochemical and biophysical research communications 1993;191(3):880-6.
1993: Hoffer M J; Hofker M H; van Eck M M; Havekes L M; Frants R R
Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: structure and genetic variability in inbred mice.
Genomics 1993;15(1):62-7.
1992: Top B; Uitterlinden A G; van der Zee A; Kastelein J J; Leuven J A; Havekes L M; Frants R R
Absence of mutations in the promoter region of the low density lipoprotein receptor gene in a large number of familial hypercholesterolaemia patients as revealed by denaturing gradient gel electrophoresis.
Human genetics 1992;89(5):561-5.
1991: de Knijff P; van den Maagdenberg A M; Stalenhoef A F; Leuven J A; Demacker P N; Kuyt L P; Frants R R; Havekes L M
Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree.
The Journal of clinical investigation 1991;88(2):643-55.
1991: Top B; van den Boorn N; van der Zee A; Havekes L M; Frants R R
Detection of allele-specific transcripts by the polymerase chain reaction (AST-PCR).
Biochemical and biophysical research communications 1991;178(3):1319-25.
1991: Kempen H J; de Knijff P; Boomsma D I; van der Voort H A; Gevers Leuven J A; Havekes L
Plasma levels of lathosterol and phytosterols in relation to age, sex, anthropometric parameters, plasma lipids, and apolipoprotein E phenotype, in 160 Dutch families.
Metabolism: clinical and experimental 1991;40(6):604-11.
1991: Groot P H; van Stiphout W A; Krauss X H; Jansen H; van Tol A; van Ramshorst E; Chin-On S; Hofman A; Cresswell S R; Havekes L
Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(3):653-62.
1991: Kempen H J; Gevers Leuven J A; van der Voort H A; de Knijff P; Havekes L
Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia.
Metabolism: clinical and experimental 1991;40(3):231-5.
1991: Mulder M; de Wit E; Havekes L M
The binding of human lipoprotein lipase treated VLDL by the human hepatoma cell line HepG2.
Biochimica et biophysica acta 1991;1081(3):308-14.
1991: Kempen H J; Vermeer M; de Wit E; Havekes L M
Vastatins inhibit cholesterol ester accumulation in human monocyte-derived macrophages.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(1):146-53.
1990: Berkhout T A; Havekes L M; Pearce N J; Groot P H
The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2.
The Biochemical journal 1990;272(1):181-6.
1990: Top B; Koeleman B P; Gevers Leuven J A; Havekes L M; Frants R R
Rearrangements in the LDL receptor gene in Dutch familial hypercholesterolemic patients and the presence of a common 4 kb deletion.
Atherosclerosis 1990;83(2-3):127-36.
1990: De Knijff P; Stalenhoef A F; Mol M J; Gevers Leuven J A; Smit J; Erkelens D W; Schouten J; Frants R R; Havekes L M
Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia.
Atherosclerosis 1990;83(1):89-97.
1990: Gevers Leuven J A; Dersjant-Roorda M C; Helmerhorst F M; de Boer R; Neymeyer-Leloux A; Havekes L
Estrogenic effect of gestodene- or desogestrel-containing oral contraceptives on lipoprotein metabolism.
American journal of obstetrics and gynecology 1990;163(1 Pt 2):358-62.
1990: Lombardi P; de Wit E; Frants R R; Havekes L M
Characterisation of the LDL receptor in Epstein-Barr virus transformed lymphocytes.
Biochimica et biophysica acta 1990;1044(1):127-32.
1990: van Eyk R; Chan L; Top B; Stalenhoef A F; Havekes L M; Frants R R
An additional MspI RFLP at the human hepatic lipase (HL) gene locus.
Nucleic acids research 1990;18(10):3110.
1990: Smit M; de Knijff P; van der Kooij-Meijs E; Groenendijk C; van den Maagdenberg A M; Gevers Leuven J A; Stalenhoef A F; Stuyt P M; Frants R R; Havekes L M
Genetic heterogeneity in familial dysbetalipoproteinemia. The E2(lys146----gln) variant results in a dominant mode of inheritance.
Journal of lipid research 1990;31(1):45-53.
1989: van den Maagdenberg A M; de Knijff P; Stalenhoef A F; Gevers Leuven J A; Havekes L M; Frants R R
Apolipoprotein E*3-Leiden allele results from a partial gene duplication in exon 4.
Biochemical and biophysical research communications 1989;165(2):851-7.
1989: Kluft C; Jie A F; Los P; de Wit E; Havekes L
Functional analogy between lipoprotein(a) and plasminogen in the binding to the kringle 4 binding protein, tetranectin.
Biochemical and biophysical research communications 1989;161(2):427-33.
1988: de Knijff P; Rosseneu M; Beisiegel U; de Keersgieter W; Frants R R; Havekes L M
Apolipoprotein A-IV polymorphism and its effect on plasma lipid and apolipoprotein concentrations.
Journal of lipid research 1988;29(12):1621-7.
1988: Smit M; de Knijff P; Rosseneu M; Bury J; Klasen E; Frants R; Havekes L
Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels.
Human genetics 1988;80(3):287-92.
1988: Smit M; van der Kooij-Meijs E; Woudt L P; Havekes L M; Frants R R
Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene.
Biochemical and biophysical research communications 1988;152(3):1282-8.
1988: Smit M; van der Kooij-Meijs E; Frants R R; Havekes L; Klasen E C
Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia.
Human genetics 1988;78(1):90-3.
1988: Havekes L M; de Knijff P; Smit M; Frants R R
The effect of apolipoprotein E allele substitutions on plasma lipid and apolipoprotein levels.
Advances in experimental medicine and biology 1988;243():87-93.
1988: Smit M; de Knijff P; Sijts A; Klasen E C; Frants R R; Havekes L M
Rare apolipoprotein E variant cosegregating with a unique APOE-C1-C2 haplotype in a normolipidemic family.
Human heredity 1988;38(5):277-82.
1987: Smit M; de Knijff P; Frants R R; Klasen E C; Havekes L M
Familial dysbetalipoproteinemic subjects with the E3/E2 phenotype exhibit an E2 isoform with only one cysteine residue.
Clinical genetics 1987;32(5):335-41.
1987: Havekes L M; de Wit E C; Princen H M
Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity.
The Biochemical journal 1987;247(3):739-46.
1987: Havekes L M; de Knijff P; Beisiegel U; Havinga J; Smit M; Klasen E
A rapid micromethod for apolipoprotein E phenotyping directly in serum.
Journal of lipid research 1987;28(4):455-63.
1987: Kempen H J; van Son K; Cohen L H; Griffioen M; Verboom H; Havekes L
Effect of ketoconazole on cholesterol synthesis and on HMG-CoA reductase and LDL-receptor activities in Hep G2 cells.
Biochemical pharmacology 1987;36(8):1245-9.
1987: Klasen E C; Talmud P J; Havekes L; de Wit E; van der Kooij-Meijs E; Smit M; Hansson G; Humphries S E
A common restriction fragment length polymorphism of the human apolipoprotein E gene and its relationship to type III hyperlipidaemia.
Human genetics 1987;75(3):244-7.
1987: Klasen E C; Smit M; de Kniff P; Gevers Leuven J; Kempen-Voogd R; Havekes L
Apolipoprotein E phenotype and gene distribution in The Netherlands.
Human heredity 1987;37(6):340-4.
1987: Havekes L; Utermann G; de Knijff P; Klasen E
Characterisation and mode of inheritance of apolipoprotein E3-Leiden.
Advances in experimental medicine and biology 1987;210():41-5.
1987: Gevers Leuven J A; vd Voort H; Kempen H J; de Wit E; Havekes L
The effect of cyclandelate on cholesterol metabolism in patients with familial hypercholesterolaemia.
Drugs 1987;33 Suppl 2():131-5.
1986: Leuven J A; Havekes L; Kempen H J
Effect of deoxycholic acid on lipoprotein and apolipoprotein levels in patients with familial hypercholesterolemia.
Atherosclerosis 1986;62(1):21-5.
1986: Leuven J A; van Stiphout W A; van Gelderen H H; Reeser H M; Havekes L; Hofman A
The effect of large doses of ethinylestradiol on apolipoprotein levels in excessively tall prepubertal girls.
Metabolism: clinical and experimental 1986;35(10):978-80.
1986: van Hinsbergh V W; Scheffer M; Havekes L; Kempen H J
Role of endothelial cells and their products in the modification of low-density lipoproteins.
Biochimica et biophysica acta 1986;878(1):49-64.
1986: Havekes L; de Wit E; Leuven J G; Klasen E; Utermann G; Weber W; Beisiegel U
Apolipoprotein E3-Leiden. A new variant of human apolipoprotein E associated with familial type III hyperlipoproteinemia.
Human genetics 1986;73(2):157-63.
1985: Mirani-Oostdijk C P; Havekes L; Van Gent C M; Frölich M; Jansen H; Terpstra J
Diurnal changes in serum triglycerides as related to changes in lipolytic enzymes, lipoproteins and hormones in patients with primary endogenous hypertriglyceridaemia on a carbohydrate-rich diet.
Atherosclerosis 1985;57(2-3):129-37.
1985: Vermeer B J; Wijsman M C; Mommaas-Kienhuis A M; Ponec M; Havekes L
Modulation of low density lipoprotein receptor activity in squamous carcinoma cells by variation in cell density.
European journal of cell biology 1985;38(2):353-60.
1985: Havekes L; Mommaas-Kienhuis A M; Schouten D; De Wit E; Scheffer M; Van Hinsbergh V W
High-affinity uptake and degradation of acetylated low density lipoprotein by confluent human vascular endothelial cells.
Atherosclerosis 1985;56(1):81-92.
1985: Mirani-Oostdijk C P; Havekes L; den Boer P J; de Wit E; Terpstra J
Diurnal course of the suitability of serum samples obtained from normal subjects and from patients with primary endogenous hypertriglyceridaemia to serve as substrate for milk lipoprotein lipase.
Scandinavian journal of clinical and laboratory investigation 1985;45(3):207-15.
1984: Leuven J A; Havekes L; van der Kooij-Pontier H A; Starmans R J; Jansen H; Bouwhuis-Hoogerwerf M L; de Pagter H A; Hessel L W
Effect of low-dose oral contraceptives on lipoproteins and lipolytic enzymes: differences between two commonly used preparations.
Metabolism: clinical and experimental 1984;33(11):1039-42.
1984: Danner S A; Wieling W; Havekes L; Leuven J G; Smit E M; Dunning A J
Effect of physical exercise on blood lipids and adipose tissue composition in young healthy men.
Atherosclerosis 1984;53(1):83-90.
1984: van Niekerk J L; Hendriks T; Gevers Leuven J A; Havekes L; de Boer H H
The lipid-lowering effects of 3-hydroxy-3-methylglutaric acid and bile acid drainage in WHHL rabbits.
Clinical science (London, England : 1979) 1984;67(4):439-44.
1984: Cohen L H; Griffioen M; Havekes L; Schouten D; van Hinsbergh V; Kempen H J
Effects of compactin, mevalonate and low-density lipoprotein on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and low-density-lipoprotein-receptor activity in the human hepatoma cell line Hep G2.
The Biochemical journal 1984;222(1):35-9.
1984: Havekes L; Schouten D; van Hinsbergh V; de Wit E
Characterisation of the binding of apolipoprotein E-free high density lipoprotein to cultured human endothelial cells.
Biochemical and biophysical research communications 1984;122(2):785-90.
1984: Kooistra T; van Hinsbergh V; Havekes L; Kempen H J
In vitro studies on origin and site of action of enzyme activity responsible for conversion of human proapoprotein A-I into apoprotein A-I.
FEBS letters 1984;170(1):109-13.
1983: van Hinsbergh V W; Havekes L; Emeis J J; van Corven E; Scheffer M
Low density lipoprotein metabolism by endothelial cells from human umbilical cord arteries and veins.
Arteriosclerosis (Dallas, Tex.) 1983;3(6):547-59.
1983: Havekes L; van Hinsbergh V; Kempen H J; Emeis J
The metabolism in vitro of human low-density lipoprotein by the human hepatoma cell line Hep G2.
The Biochemical journal 1983;214(3):951-8.
1983: Mirani-Oostdijk C P; Havekes L; Terpstra J; Frölich M; Van Gent C M; Jansen H
Diurnal changes in serum triglycerides as related to changes in lipolytic enzymes, (apo) lipoproteins and hormones in normal subjects on a carbohydrate-rich diet.
European journal of clinical investigation 1983;13(4):301-9.
1982: Groot P H; Scheek L M; Havekes L; van Noort W L; van't Hooft F M
A one-step separation of human serum high density lipoproteins 2 and 3 by rate-zonal density gradient ultracentrifugation in a swinging bucket rotor.
Journal of lipid research 1982;23(9):1342-53.
1981: Havekes L; Hemmink J; de Wit E
Low-density-lipoprotein apoprotein B in plasma as measured by radial immunodiffusion and rocket immunoelectrophoresis.
Clinical chemistry 1981;27(11):1829-33.
1981: Havekes L; van Gent C M; Stegerhoek C I; Arntzenius A C; Hessel L W
High density lipoprotein cholesterol and apolipoprotein A-I levels in 32-33-year-old women on steroid contraceptives-differences between two frequently used low-estrogen pills.
Clinica chimica acta; international journal of clinical chemistry 1981;116(2):223-9.
1981: Havekes L; Vermeer B J; Brugman T; Emeis J
Binding of LP(a) to the low density lipoprotein receptor of human fibroblasts.
FEBS letters 1981;132(2):169-73.
1980: Havekes L; Vermeer B J; de Wit E; Emeis J J; Vaandrager H; van Gent C M; Koster J F
Suppression of cholesterol synthesis in cultured fibroblasts from a patient with homozygous familial hypercholesterolemia by her own low density lipoprotein density fraction. A possible role of apolipoprotein E.
Biochimica et biophysica acta 1980;617(3):529-35.

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