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Frits Haverkate

Research Profile

Chemicals & Drugs

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Angina Pectoris

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Piet Meijer; Frits Haverkate; Cornelis Kluft
Performance goals for the laboratory testing of antithrombin, protein C and protein S.
Piet Meijer; Frits Haverkate
An external quality assessment program for von Willebrand factor laboratory analysis: an overview from the European concerted action on thrombosis and disabilities foundation.
Piet Meijer; Frits Haverkate; Cornelis Kluft; Philippe de Moerloose; Bert Verbruggen; Michael Spannagl
A model for the harmonisation of test results of different quantitative D-dimer methods.

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All Publications

2006: Piet Meijer; Frits Haverkate; Cornelis Kluft
Performance goals for the laboratory testing of antithrombin, protein C and protein S.
Thrombosis and haemostasis 2006;96(5):584-9.
2006: Piet Meijer; Frits Haverkate
An external quality assessment program for von Willebrand factor laboratory analysis: an overview from the European concerted action on thrombosis and disabilities foundation.
Seminars in thrombosis and hemostasis 2006;32(5):485-91.
2006: Piet Meijer; Frits Haverkate; Cornelis Kluft; Philippe de Moerloose; Bert Verbruggen; Michael Spannagl
A model for the harmonisation of test results of different quantitative D-dimer methods.
Thrombosis and haemostasis 2006;95(3):567-72.
2006: Rogier M Bertina; Nico H van Tilburg; Frits Haverkate; Bonno N Bouma; Peter A von dem Borne; Joost C M Meijers; W Campbell; D Eaton; Dirk F Hendriks; Johan L Willemse
Discovery of thrombin activatable fibrinolysis inhibitor (TAFI).
Journal of thrombosis and haemostasis : JTH 2006;4(1):256-7.
2005: Michael Spannagl; Frits Haverkate; Hans Reinauer; Piet Meijer
The performance of quantitative D-dimer assays in laboratory routine.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2005;16(6):439-43.
2005: Piet Meijer; Frits Haverkate
External quality assessment and the laboratory diagnosis of thrombophilia.
Seminars in thrombosis and hemostasis 2005;31(1):59-65.
2003: Piet Meijer; Cornelis Kluft; Frits Haverkate; Moniek P M de Maat
The long-term within- and between-laboratory variability for assay of antithrombin, and proteins C and S: results derived from the external quality assessment program for thrombophilia screening of the ECAT Foundation.
Journal of thrombosis and haemostasis : JTH 2003;1(4):748-53.
2003: Johanna van der Bom; Michiel Bots; Frits Haverkate; Cornelis Kluft; Diederick Grobbee
The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1.
Blood 2003;101(5):1841-4.
2002: Moniek P M de Maat; Frits Haverkate; Cornelis Kluft
Relationship between CRP and clinical course of unstable angina depends on assay method.
Vascular pharmacology 2002;39(3):113-5.
2002: Piet Meijer; Moniek P M de Maat; Cornelis Kluft; Frits Haverkate; Hans C van Houwelingen
Long-term analytical performance of hemostasis field methods as assessed by evaluation of the results of an external quality assessment program for antithrombin.
Clinical chemistry 2002;48(7):1011-5.
2001: Johanna van der Bom; Michiel Bots; Frits Haverkate; Piet Meijer; Albert Hofman; Cornelis Kluft; Diederick Grobbee
Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease.
Thrombosis and haemostasis 2001;85(2):234-9.
2000: Moniek P M de Maat; J M Ossewaarde; PW Verheggen; Cornelis Kluft; VM Cats; Frits Haverkate
Antibodies to Chlamydia pneumoniae and clinical course in patients with unstable angina pectoris.
Atherosclerosis 2000;153(2):499-504.
2000: Moniek P M de Maat; Piet Meijer; W Nieuwenhuizen; Frits Haverkate; Cornelis Kluft
Performance of semiquantitative and quantitative D-dimer assays in the ECAT external quality assessment program.
Seminars in thrombosis and hemostasis 2000;26(6):625-30.
1999: PW Verheggen; Moniek P M de Maat; VM Cats; Frits Haverkate; Aeilko H Zwinderman; Cornelis Kluft; A V G Bruschke
Inflammatory status as a main determinant of outcome in patients with unstable angina, independent of coagulation activation and endothelial cell function.
European heart journal 1999;20(8):567-74.
1999: Johanna van der Bom; Michiel Bots; Frits Haverkate; P Meyer; Albert Hofman; Diederick Grobbee; Cornelis Kluft
Fibrinolytic activity in peripheral atherosclerosis in the elderly.
Thrombosis and haemostasis 1999;81(2):275-80.
1998: Frits Haverkate; J Koopman; Moniek P M de Maat
Statins and fibrinogen.
Lancet 1998;351(9113):1430-1; author reply 1431-2.
1998: Michiel Bots; Monique Breteler; F van Kooten; Frits Haverkate; Piet Meijer; Peter J Koudstaal; Diederick Grobbee; Cornelis Kluft
Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study.
Haemostasis 1998;28(3-4):216-22.
1998: Michiel Bots; F van Kooten; Monique Breteler; P Eline Slagboom; Albert Hofman; Frits Haverkate; Piet Meijer; Peter J Koudstaal; Diederick Grobbee; Cornelis Kluft
Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study.
Haemostasis 1998;28(3-4):209-15.
1998: Johanna van der Bom; Moniek P M de Maat; Michiel Bots; Frits Haverkate; P T de Jong; Albert Hofman; Cornelis Kluft; Diederick Grobbee
Elevated plasma fibrinogen: cause or consequence of cardiovascular disease?
Arteriosclerosis, thrombosis, and vascular biology 1998;18(4):621-5.
1998: F van Kooten; Michiel Bots; Monique Breteler; Frits Haverkate; John C van Swieten; Diederick Grobbee; Peter J Koudstaal; Cornelis Kluft
The Dutch Vascular Factors in Dementia Study: rationale and design.
Journal of neurology 1998;245(1):32-9.
1997: Johanna van der Bom; P de Knijff; Frits Haverkate; Michiel Bots; Piet Meijer; P T de Jong; Albert Hofman; Cornelis Kluft; Diederick Grobbee
Tissue plasminogen activator and risk of myocardial infarction. The Rotterdam Study.
Circulation 1997;95(12):2623-7.
1997: PW Verheggen; B T Heymans; P Eline Slagboom; Frits Haverkate; VM Cats
Normal prevalence of factor V Leiden gene mutation in patients with severe unstable angina.
Thrombosis and haemostasis 1997;77(6):1218.
1997: Frits Haverkate; Simon G Thompson; S D Pyke; J R Gallimore; M B Pepys
Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group.
Lancet 1997;349(9050):462-6.
1996: I Juhan-Vague; S D Pyke; M C Alessi; J Jespersen; Frits Haverkate; Simon G Thompson
Fibrinolytic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. ECAT Study Group. European Concerted Action on Thrombosis and Disabilities.
Circulation 1996;94(9):2057-63.
1996: Johanna van der Bom; Michiel Bots; Frits Haverkate; P Eline Slagboom; Piet Meijer; P T de Jong; Albert Hofman; Diederick Grobbee; Cornelis Kluft
Reduced response to activated protein C is associated with increased risk for cerebrovascular disease.
Annals of internal medicine 1996;125(4):265-9.
1995: Frits Haverkate; Simon G Thompson; F Duckert
Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group.
Thrombosis and haemostasis 1995;73(4):561-7.
1995: Simon G Thompson; Joachim Kienast; S D Pyke; Frits Haverkate; Jürgen van de Loo
Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group.
The New England journal of medicine 1995;332(10):635-41.
1993: P Grailhe; C Boyer-Neumann; Frits Haverkate; J Grimbergen; M J Larrieu; Eduardo Anglés-Cano
The mutation in fibrinogen Bicêtre II (gamma Asn308-->Lys) does not affect the binding of t-PA and plasminogen to fibrin.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(5):679-87.
1993: J Koopman; Frits Haverkate; J Grimbergen; Susan T Lord; M W Mosesson; J P DiOrio; K S Siebenlist; C Legrand; J Soria; C Soria
Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.
The Journal of clinical investigation 1993;91(4):1637-43.
1993: N J de Fouw; N H van Tilburg; Frits Haverkate; R M Bertina
Activated protein C accelerates clot lysis by virtue of its anticoagulant activity.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(2):201-10.
1992: R M Bertina; N H van Tilburg; N J de Fouw; Frits Haverkate
Thrombin, a link between coagulation activation and fibrinolysis.
Annals of the New York Academy of Sciences 1992;667():239-48.
1992: J Koopman; Frits Haverkate; J Grimbergen; R Egbring; Susan T Lord
Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA).
Blood 1992;80(8):1972-9.
1992: J Koopman; Frits Haverkate; Susan T Lord; J Grimbergen; P M Mannucci
Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr.
The Journal of clinical investigation 1992;90(1):238-44.
1992: Frits Haverkate; Simon G Thompson; J C van de Loo
The relationship between hemostatic tests and cardiovascular risk factors in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities (ECAT) Angina Pectoris Group.
Annals of epidemiology 1992;2(4):521-4.
1992: J Koopman; Frits Haverkate; J Grimbergen; L Engesser; I Nováková; A F Kerst; Susan T Lord
Abnormal fibrinogens IJmuiden (B beta Arg14----Cys) and Nijmegen (B beta Arg44----Cys) form disulfide-linked fibrinogen-albumin complexes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3478-82.
1991: J Koopman; Frits Haverkate; E Briët; Susan T Lord
A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization.
The Journal of biological chemistry 1991;266(20):13456-61.
1991: Simon G Thompson; G Calori; J M Thomson; Frits Haverkate; F Duckert
The impact of sequential quality assessment exercises on laboratory performance: the multicentre ECAT Angina Pectoris Study. Report from the European Concerted Action on Thrombosis and Disabilities (ECAT).
Thrombosis and haemostasis 1991;65(2):149-52.
1990: N J de Fouw; Frits Haverkate; R M Bertina
Protein C and fibrinolysis: a link between coagulation and fibrinolysis.
Advances in experimental medicine and biology 1990;281():235-43.
1989: Simon G Thompson; F Duckert; Frits Haverkate; J M Thomson
The measurement of haemostatic factors in 16 European laboratories: quality assessment for the Multicentre ECAT Angina Pectoris Study. Report from the European Concerted Action on Thrombosis and Disabilities (ECAT).
Thrombosis and haemostasis 1989;61(2):301-6.
1988: N J de Fouw; Y F de Jong; Frits Haverkate; R M Bertina
Activated protein C increases fibrin clot lysis by neutralization of plasminogen activator inhibitor--no evidence for a cofactor role of protein S.
Thrombosis and haemostasis 1988;60(2):328-33.
1988: L Engesser; J Koopman; G de Munk; Frits Haverkate; I Nováková; Jan H Verheijen; E Briët; E J Brommer
Fibrinogen Nijmegen: congenital dysfibrinogenemia associated with impaired t-PA mediated plasminogen activation and decreased binding of t-PA.
Thrombosis and haemostasis 1988;60(1):113-20.
1987: Frits Haverkate; J Koopman; C Kluft; A D'Angelo; M Cattaneo; P M Mannucci
Fibrinogens "Milano II"- and "Naples".
Thrombosis and haemostasis 1987;57(3):375.
1987: N J de Fouw; V W van Hinsbergh; Y F de Jong; Frits Haverkate; R M Bertina
The interaction of activated protein C and thrombin with the plasminogen activator inhibitor released from human endothelial cells.
Thrombosis and haemostasis 1987;57(2):176-82.
1987: J W Jansen; Frits Haverkate; J Koopman; H K Nieuwenhuis; C Kluft; T A Boschman
Influence of factor XIIIa activity on human whole blood clot lysis in vitro.
Thrombosis and haemostasis 1987;57(2):171-5.
1987: J Koopman; Frits Haverkate; P Koppert; W Nieuwenhuizen; E J Brommer; W G Van der Werf
New enzyme immunoassay of fibrin-fibrinogen degradation products in plasma using a monoclonal antibody.
The Journal of laboratory and clinical medicine 1987;109(1):75-84.
1986: P W Koppert; J Koopman; Frits Haverkate; W Nieuwenhuizen
Production and characterization of a monoclonal antibody reactive with a specific neoantigenic determinant (comprising B beta 54-118) in degradation products of fibrin and of fibrinogen.
Blood 1986;68(2):437-41.
1986: N J de Fouw; Frits Haverkate; R M Bertina; J Koopman; A van Wijngaarden; V W van Hinsbergh
The cofactor role of protein S in the acceleration of whole blood clot lysis by activated protein C in vitro.
Blood 1986;67(4):1189-92.
1986: Frits Haverkate; J Koopman; C Kluft; A D'Angelo; M Cattaneo; P M Mannucci
Fibrinogen Milano II: a congenital dysfibrinogenaemia associated with juvenile arterial and venous thrombosis.
Thrombosis and haemostasis 1986;55(1):131-5.
1985: E J Brommer; A L Boks; J Koopman; Frits Haverkate
Protraction of whole blood and plasma clot lysis in patients with high levels of an inhibitor of tissue-type plasminogen activator.
Thrombosis research 1985;39(3):271-80.
1985: V W van Hinsbergh; R M Bertina; A van Wijngaarden; N H van Tilburg; J J Emeis; Frits Haverkate
Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium.
Blood 1985;65(2):444-51.
1983: L Sterrenberg; M Gravesen; Frits Haverkate; W Nieuwenhuizen
Granulocyte enzyme mediated degradation of human fibrinogen in plasma in vitro.
Thrombosis research 1983;31(5):719-28.
1981: A Hensen; E J Brommer; M Gravesen; Frits Haverkate
[Familial dysfibrinogenemia; fibrinogen Haarlem I and II].
Nederlands tijdschrift voor geneeskunde 1981;125(19):734-7.