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Jacek Hawiger

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TOP 3
Yan Liu; Amy S Major; Daniel Moore; Ruth Ann Veach; Jozef Zienkiewicz; Robert D Collins; Curtis L Gabriel; Jacek Hawiger
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
Qing Lin; Yan Liu; Daniel Moore; Sydney K Elizer; Jacek Hawiger; Ruth A Veach; H Earl Ruley
Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
Ruth Ann Veach; Jozef Zienkiewicz; Robert D Collins; Jacek Hawiger
Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy.

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All Publications

2013: Yan Liu; Amy S Major; Daniel Moore; Ruth Ann Veach; Jozef Zienkiewicz; Robert D Collins; Curtis L Gabriel; Jacek Hawiger
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
Journal of the American Heart Association 2013;2(2):e000093.
2012: Qing Lin; Yan Liu; Daniel Moore; Sydney K Elizer; Jacek Hawiger; Ruth A Veach; H Earl Ruley
Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(6):2493-7.
2012: Ruth Ann Veach; Jozef Zienkiewicz; Robert D Collins; Jacek Hawiger
Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy.
PloS one 2012;7(1):e30527.
2010: Tynetta C Fletcher; Antonio DiGiandomenico; Jacek Hawiger
Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3.
The Journal of biological chemistry 2010;285(24):18727-36.
2010: Daniel Moore; Jozef Zienkiewicz; Peggy L Kendall; Danya Liu; Xueyan Liu; Ruth Ann Veach; Robert D Collins; Jacek Hawiger
In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes.
PloS one 2010;5(10):e13235.
2009: Danya Liu; Jozef Zienkiewicz; Antonio DiGiandomenico; Jacek Hawiger
Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(5):796-802.
2009: Antonio DiGiandomenico; Lukasz S Wylezinski; Jacek Hawiger
Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling.
Science signaling 2009;2(80):ra37.
2008: Cristina Zanchi; Carla Zoja; Marina Morigi; Federica Valsecchi; Xue Yan Liu; Daniela Rottoli; Monica Locatelli; Simona Buelli; Anna Pezzotta; Paola Mapelli; Joyce Geelen; Giuseppe Remuzzi; Jacek Hawiger
Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1460-9.
2006: Jelena S Bezbradica; Laura E Gordy; Aleksandar Stanic; Srdjan Dragovic; Timothy Hill; Jacek Hawiger; Derya Unutmaz; Luc Van Kaer; Sebastian JOYCE
Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.
Immunity 2006;25(3):487-97.
2005: Daewoong Jo; Danya Liu; Shan Yao; Robert D Collins; Jacek Hawiger
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis.
Nature medicine 2005;11(8):892-8.
2005: Chunsheng Li; Jozef Zienkiewicz; Jacek Hawiger
Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway.
The Journal of biological chemistry 2005;280(28):26152-9.
2004: Danya Liu; Chunsheng Li; Yiliu Chen; Christie Burnett; Xue Yan Liu; Sheila Downs; Robert D Collins; Jacek Hawiger
Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide.
The Journal of biological chemistry 2004;279(46):48434-42.
2004: Danya Liu; Xue Yan Liu; Daniel Robinson; Christie Burnett; Charity Jackson; Louis Seele; Ruth Ann Veach; Sheila Downs; Robert D Collins; Dean W Ballard; Jacek Hawiger
Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor.
The Journal of biological chemistry 2004;279(18):19239-46.
2004: Ruth Ann Veach; Danya Liu; Shan Yao; Yiliu Chen; Xue Yan Liu; Sheila Downs; Jacek Hawiger
Receptor/transporter-independent targeting of functional peptides across the plasma membrane.
The Journal of biological chemistry 2004;279(12):11425-31.
2001: Jacek Hawiger
Innate immunity and inflammation: a transcriptional paradigm.
Immunologic research 2001;23(2-3):99-109.
2001: Eugene M Oltz; Jacek Hawiger
Immunology at Vanderbilt University.
Immunologic research 2001;23(2-3):97-8.
2000: X Y Liu; D Robinson; Ruth Ann Veach; Danya Liu; S Timmons; Robert D Collins; Jacek Hawiger
Peptide-directed suppression of a pro-inflammatory cytokine response.
The Journal of biological chemistry 2000;275(22):16774-8.
1999: S Ware; John P Donahue; Jacek Hawiger; Wayne F Anderson
Structure of the fibrinogen gamma-chain integrin binding and factor XIIIa cross-linking sites obtained through carrier protein driven crystallization.
Protein science : a publication of the Protein Society 1999;8(12):2663-71.
1999: Jacek Hawiger; Ruth Ann Veach; Xue Yan Liu; S Timmons; Dean W Ballard
IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells.
Blood 1999;94(5):1711-6.
1999: Jacek Hawiger
Noninvasive intracellular delivery of functional peptides and proteins.
Current opinion in chemical biology 1999;3(1):89-94.
1998: T R Torgerson; A D Colosia; John P Donahue; YZ Lin; Jacek Hawiger
Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6084-92.
1998: L Zhang; T R Torgerson; Xue Yan Liu; S Timmons; A D Colosia; Jacek Hawiger; James P Tam
Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9184-9.
1998: ZL Chu; J A DiDonato; Jacek Hawiger; Dean W Ballard
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta.
The Journal of biological chemistry 1998;273(26):15891-4.
1997: Jacek Hawiger
Cellular import of functional peptides to block intracellular signaling.
Current opinion in immunology 1997;9(2):189-94.
1996: X Y Liu; S Timmons; Y Z Lin; Jacek Hawiger
Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11819-24.
1996: Y Z Lin; S Y Yao; Jacek Hawiger
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways.
The Journal of biological chemistry 1996;271(10):5305-8.
1995: Y Z Lin; S Y Yao; R A Veach; T R Torgerson; Jacek Hawiger
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence.
The Journal of biological chemistry 1995;270(24):14255-8.
1995: Jacek Hawiger
Adhesive ends of fibrinogen and its antiadhesive peptides: the end of a saga?
Seminars in hematology 1995;32(2):99-109.
1995: R Donald; Dean W Ballard; Jacek Hawiger
Proteolytic processing of NF-kappa B/I kappa B in human monocytes. ATP-dependent induction by pro-inflammatory mediators.
The Journal of biological chemistry 1995;270(1):9-12.
1994: John P Donahue; H Patel; W F Anderson; Jacek Hawiger
Three-dimensional structure of the platelet integrin recognition segment of the fibrinogen gamma chain obtained by carrier protein-driven crystallization.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12178-82.
1994: John P Donahue; N Sugg; Jacek Hawiger
The integrin alpha v gene: identification and characterization of the promoter region.
Biochimica et biophysica acta 1994;1219(1):228-32.
1993: M A Read; S R Cordle; R A Veach; C D Carlisle; Jacek Hawiger
Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9887-91.
1993: S R Cordle; R Donald; M A Read; Jacek Hawiger
Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.
The Journal of biological chemistry 1993;268(16):11803-10.
1992: M Blumenstein; G R Matsueda; S Timmons; Jacek Hawiger
A beta-turn is present in the 392-411 segment of the human fibrinogen gamma-chain. Effects of structural changes in this segment on affinity to antibody 4A5.
Biochemistry 1992;31(44):10692-8.
1992: Jacek Hawiger
Introduction to platelet structural and functional organization.
Methods in enzymology 1992;215():3-5.
1992: Jacek Hawiger; S Timmons
Binding of fibrinogen and von Willebrand factor to platelet glycoprotein IIb-IIIa complex.
Methods in enzymology 1992;215():228-43.
1992: Jacek Hawiger
Repertoire of platelet receptors.
Methods in enzymology 1992;215():131-6.
1991: C S Chen; Jacek Hawiger
Reactivity of synthetic peptide analogs of adhesive proteins in regard to the interaction of human endothelial cells with extracellular matrix.
Blood 1991;77(10):2200-6.
1991: E Shiba; J N Lindon; L Kushner; G R Matsueda; Jacek Hawiger; M Kloczewiak; B Kudryk; E W Salzman
Antibody-detectable changes in fibrinogen adsorption affecting platelet activation on polymer surfaces.
The American journal of physiology 1991;260(5 Pt 1):C965-74.
1991: Jacek Hawiger
Adhesive interactions of platelets and their blockade.
Annals of the New York Academy of Sciences 1991;614():270-8.
1990: Kenneth A Bauer; B L Kass; Hugo ten Cate; Jacek Hawiger; R D Rosenberg
Factor IX is activated in vivo by the tissue factor mechanism.
Blood 1990;76(4):731-6.
1990: J Grabarek; G R Her; V N Reinhold; Jacek Hawiger
Endotoxic lipid A interaction with human platelets. Structure-function analysis of lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide.
The Journal of biological chemistry 1990;265(14):8117-21.
1990: R S Johnson; G R Her; J Grabarek; Jacek Hawiger; V N Reinhold
Structural characterization of monophosphoryl lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide.
The Journal of biological chemistry 1990;265(14):8108-16.
1990: Mario Romano; Jacek Hawiger
Interaction of endotoxic lipid A and lipid X with purified human platelet protein kinase C.
The Journal of biological chemistry 1990;265(3):1765-70.
1989: Kenneth A Bauer; B L Kass; Hugo ten Cate; M A Bednarek; Jacek Hawiger; R D Rosenberg
Detection of factor X activation in humans.
Blood 1989;74(6):2007-15.
1989: S Timmons; M A Bednarek; M Kloczewiak; Jacek Hawiger
Antiplatelet "hybrid" peptides analogous to receptor recognition domains on gamma and alpha chains of human fibrinogen.
Biochemistry 1989;28(7):2919-23.
1989: M Kloczewiak; S Timmons; M A Bednarek; M Sakon; Jacek Hawiger
Platelet receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogues.
Biochemistry 1989;28(7):2915-9.
1989: Jacek Hawiger; M Kloczewiak; M A Bednarek; S Timmons
Platelet receptor recognition domains on the alpha chain of human fibrinogen: structure-function analysis.
Biochemistry 1989;28(7):2909-14.
1989: S Timmons; Jacek Hawiger
Isolation of human platelets by albumin gradient and gel filtration.
Methods in enzymology 1989;169():11-21.
1988: J Grabarek; S Timmons; Jacek Hawiger
Modulation of human platelet protein kinase C by endotoxic lipid A.
The Journal of clinical investigation 1988;82(3):964-71.
1987: M Kloczewiak; S Timmons; Jacek Hawiger
Reactivity of chemically cross-linked fibrinogen and its fragments D toward the staphylococcal clumping receptor.
Biochemistry 1987;26(19):6152-6.
1987: Jacek Hawiger
Macromolecules that link platelets following vessel wall injury.
Annals of the New York Academy of Sciences 1987;509():131-41.
1986: S Timmons; J Grabarek; M Kloczewiak; Jacek Hawiger
Mechanism of human platelet activation by endotoxic glycolipid-bearing mutant Re595 of Salmonella minnesota.
Blood 1986;68(5):1015-23.
1986: G McManama; J N Lindon; M Kloczewiak; M A Smith; J A Ware; Jacek Hawiger; E W Merrill; E W Salzman
Platelet aggregation by fibrinogen polymers crosslinked across the E domain.
Blood 1986;68(2):363-71.
1986: S Timmons; Jacek Hawiger
von Willebrand factor can substitute for plasma fibrinogen in ADP-induced platelet aggregation.
Transactions of the Association of American Physicians 1986;99():226-35.
1984: S Timmons; M Kloczewiak; Jacek Hawiger
ADP-dependent common receptor mechanism for binding of von Willebrand factor and fibrinogen to human platelets.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(15):4935-9.
1984: R L Nachman; L L Leung; M Kloczewiak; Jacek Hawiger
Complex formation of platelet membrane glycoproteins IIb and IIIa with the fibrinogen D domain.
The Journal of biological chemistry 1984;259(13):8584-8.
1984: M Kloczewiak; S Timmons; T J Lukas; Jacek Hawiger
Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain.
Biochemistry 1984;23(8):1767-74.
1983: Jacek Hawiger; M Kloczewiak; S Timmons; D Strong; R F Doolittle
Interaction of fibrinogen with staphylococcal clumping factor and with platelets.
Annals of the New York Academy of Sciences 1983;408():521-35.
1983: M Kloczewiak; S Timmons; Jacek Hawiger
Recognition site for the platelet receptor is present on the 15-residue carboxy-terminal fragment of the gamma chain of human fibrinogen and is not involved in the fibrin polymerization reaction.
Thrombosis research 1983;29(2):249-55.
1982: M Kloczewiak; S Timmons; Jacek Hawiger
Localization of a site interacting with human platelet receptor on carboxy-terminal segment of human fibrinogen gamma chain.
Biochemical and biophysical research communications 1982;107(1):181-7.
1982: Donna Strong; A P Laudano; Jacek Hawiger; R F Doolittle
Isolation, characterization, and synthesis of peptides from human fibrinogen that block the staphylococcal clumping reaction and construction of a synthetic clumping particle.
Biochemistry 1982;21(6):1414-20.
1982: Jacek Hawiger; S Timmons; Donna Strong; B A Cottrell; M Riley; R F Doolittle
Identification of a region of human fibrinogen interacting with staphylococcal clumping factor.
Biochemistry 1982;21(6):1407-13.
1982: Jacek Hawiger; S Timmons; M Kloczewiak; Donna Strong; R F Doolittle
gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(6):2068-71.