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Alastair Hawkins

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Charles E Nichols; K El Omari; P Thompson; Ian G Charles; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; David K Stammers
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.
Emilio Lence; Antonio Luis Llamas-Saiz; José M Otero; Antonio Peón; Verónica F V Prazeres; Lorena Tizón; Mark van Raaij; Gavin C Fox; Alastair R Hawkins; Heather Lamb; Concepción González-Bello
Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.
Beatriz Blanco; Luis Castedo; Alastair R Hawkins; Heather Lamb; Antonio Peón; Antía Sedes; Concepción González-Bello
Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency.

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2013: Charles E Nichols; K El Omari; P Thompson; Ian G Charles; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; David K Stammers
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex.
Protein science : a publication of the Protein Society 2013;22(5):628-40.
2013: Emilio Lence; Antonio Luis Llamas-Saiz; José M Otero; Antonio Peón; Verónica F V Prazeres; Lorena Tizón; Mark van Raaij; Gavin C Fox; Alastair R Hawkins; Heather Lamb; Concepción González-Bello
Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.
ACS chemical biology 2013;8(3):568-77.
2012: Beatriz Blanco; Luis Castedo; Alastair R Hawkins; Heather Lamb; Antonio Peón; Antía Sedes; Concepción González-Bello
Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency.
Organic & biomolecular chemistry 2012;10(18):3662-76.
2011: Kamel El Omari; Alastair R Hawkins; Michael Lockyer; K L Powell; Jingshan Ren; Nicola G A Abrescia; Balvinder Dhaliwal; David K Stammers
Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 10):1179-83.
2011: Lorena Tizón; Mark van Raaij; José A Ainsa; Luis Castedo; Gavin C Fox; Alastair R Hawkins; Heather Lamb; Antonio Luis Llamas-Saiz; José M Otero; Verónica F V Prazeres; Concepción González-Bello
A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
Journal of medicinal chemistry 2011;54(17):6063-84.
2011: Anna L Stamp; Ian G Charles; Kamel El Omari; Alastair R Hawkins; Heather K Lamb; Michael Lockyer; Paul Owen; David K Stammers
Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351.
Proteins 2011;79(7):2352-7.
2011: Sonia Paz; Lorena Tizón; José M Otero; Antonio L Llamas-Saiz; Gavin C Fox; Mark van Raaij; Heather Lamb; Alastair R Hawkins; Adrian J Lapthorn; Luis Castedo; Concepción González-Bello
Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase.
ChemMedChem 2011;6(2):266-72.
2010: Antonio Peón; José M Otero; Lorena Tizón; Verónica F V Prazeres; Antonio L Llamas-Saiz; Gavin C Fox; Mark van Raaij; Heather Lamb; Alastair R Hawkins; Federico Gago; Luis Castedo; Concepción González-Bello
Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids.
ChemMedChem 2010;5(10):1726-33.
2010: Anna L Stamp; Paul Owen; Kamel El Omari; Charles E Nichols; Michael Lockyer; Heather K Lamb; Ian G Charles; Alastair R Hawkins; David K Stammers
Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.
Protein science : a publication of the Protein Society 2010;19(10):1897-905.
2010: Xiao Zhao; Samantha L Hume; Christopher Johnson; Paul Thompson; Junyong Huang; Joe Gray; Heather K Lamb; Alastair R Hawkins
The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases.
Protein science : a publication of the Protein Society 2010;19(7):1405-19.
2010: Verónica F V Prazeres; Lorena Tizón; José M Otero; Pablo Guardado Calvo; Antonio L Llamas-Saiz; Mark van Raaij; Luis Castedo; Heather Lamb; Alastair R Hawkins; Concepción González-Bello
Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.
Journal of medicinal chemistry 2010;53(1):191-200.
2009: Verónica F V Prazeres; Luis Castedo; Heather Lamb; Alastair R Hawkins; Concepción González-Bello
2-substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase.
ChemMedChem 2009;4(12):1980-4.
2008: Kamel El Omari; K Scott; Balvinder Dhaliwal; Jingshan Ren; Nicola G A Abrescia; J Budworth; Michael Lockyer; K L Powell; Alastair R Hawkins; David K Stammers
Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 11):1019-23.
2008: Masayo Kotaka; Christopher Johnson; Heather K Lamb; Alastair R Hawkins; Jingshan Ren; David K Stammers
Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.
Journal of molecular biology 2008;381(2):373-82.
2008: Cristina Sánchez-Sixto; Verónica F V Prazeres; Luis Castedo; Se Won Suh; Heather Lamb; Alastair R Hawkins; F Javier Cañada; Jesús Jiménez-Barbero; Concepción González-Bello
Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies.
ChemMedChem 2008;3(5):756-70.
2007: Charles E Nichols; C Johnson; Heather K Lamb; Michael Lockyer; Ian G Charles; Alastair R Hawkins; David K Stammers
Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):922-8.
2007: Heather K Lamb; Paul Thompson; Catherine Elliott; Ian G Charles; Jamie Richards; Michael Lockyer; Nicholas Watkins; Charles Nichols; David K Stammers; Clive R Bagshaw; Alan Cooper; Alastair R Hawkins
Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.
Protein science : a publication of the Protein Society 2007;16(11):2391-402.
2007: Charles E Nichols; Heather K Lamb; Michael Lockyer; Ian G Charles; Susan Pyne; Alastair R Hawkins; David K Stammers
Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.
Proteins 2007;68(1):13-25.
2007: Verónica F V Prazeres; Cristina Sánchez-Sixto; Luis Castedo; Heather Lamb; Alastair R Hawkins; Alan Riboldi-Tunnicliffe; John R Coggins; Adrian J Lapthorn; Concepción González-Bello
Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase.
ChemMedChem 2007;2(2):194-207.
2006: Masayo Kotaka; Jingshan Ren; Michael Lockyer; Alastair R Hawkins; David K Stammers
Structures of R- and T-state Escherichia coli aspartokinase III. Mechanisms of the allosteric transition and inhibition by lysine.
The Journal of biological chemistry 2006;281(42):31544-52.
2006: Kamel El Omari; Balvinder Dhaliwal; Michael Lockyer; Ian G Charles; Alastair R Hawkins; David K Stammers
Structure of Staphylococcus aureus guanylate monophosphate kinase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 10):949-53.
2006: Verónica F V Prazeres; Cristina Sánchez-Sixto; Luis Castedo; Angeles Canales; F Javier Cañada; Jesús Jiménez-Barbero; Heather Lamb; Alastair R Hawkins; Concepción González-Bello
Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy.
ChemMedChem 2006;1(9):990-6.
2006: Balvinder Dhaliwal; Jingshan Ren; Michael Lockyer; Ian G Charles; Alastair R Hawkins; David K Stammers
Structure of Staphylococcus aureus cytidine monophosphate kinase in complex with cytidine 5'-monophosphate.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):710-5.
2006: Charles E Nichols; C Johnson; Michael Lockyer; Ian G Charles; Heather K Lamb; Alastair R Hawkins; David K Stammers
Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog.
Proteins 2006;64(1):111-23.
2006: Masayo Kotaka; Balvinder Dhaliwal; Jingshan Ren; Charles E Nichols; Richard Angell; Michael Lockyer; Alastair R Hawkins; David K Stammers
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.
Protein science : a publication of the Protein Society 2006;15(4):774-84.
2006: Heather K Lamb; Christopher Mee; Weiming XU; Lizhi Liu; Sylvie Blond; Alan Cooper; Ian G Charles; Alastair R Hawkins
The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP.
The Journal of biological chemistry 2006;281(13):8796-805.
2005: Jingshan Ren; Masayo Kotaka; Michael Lockyer; Heather K Lamb; Alastair R Hawkins; David K Stammers
GTP cyclohydrolase II structure and mechanism.
The Journal of biological chemistry 2005;280(44):36912-9.
2005: Cristina Sánchez-Sixto; Verónica F V Prazeres; Luis Castedo; Heather Lamb; Alastair R Hawkins; Concepción González-Bello
Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase.
Journal of medicinal chemistry 2005;48(15):4871-81.
2004: Heather K Lamb; Jingshan Ren; Alison Park; Christopher Johnson; Kris Leslie; Simon Cocklin; Paul Thompson; Christopher Mee; Alan Cooper; David K Stammers; Alastair R Hawkins
Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.
Protein science : a publication of the Protein Society 2004;13(12):3127-38.
2004: Charles E Nichols; Jingshan Ren; Kris Leslie; Balvinder Dhaliwal; Michael Lockyer; Ian G Charles; Alastair R Hawkins; David K Stammers
Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
Journal of molecular biology 2004;343(3):533-46.
2004: Balvinder Dhaliwal; Charles E Nichols; Jingshan Ren; Michael Lockyer; Ian G Charles; Alastair R Hawkins; David K Stammers
Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase.
FEBS letters 2004;574(1-3):49-54.
2004: Charles E Nichols; Michael Lockyer; Alastair R Hawkins; David K Stammers
Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments.
Proteins 2004;56(3):625-8.
2004: Charles E Nichols; Balvinder Dhaliwal; Michael Lockyer; Alastair R Hawkins; David K Stammers
High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate beta-semialdehyde dehydrogenase.
Journal of molecular biology 2004;341(3):797-806.
2004: Alison Park; Heather K Lamb; Charlie Nichols; Jonathan D Moore; Katherine A Brown; Alan Cooper; Ian G Charles; David K Stammers; Alastair R Hawkins
Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.
Protein science : a publication of the Protein Society 2004;13(8):2108-19.
2004: Charles E Nichols; Alastair R Hawkins; David K Stammers
Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 A resolution from crystals grown following enzyme turnover.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 5):971-3.
2003: Heather K Lamb; Kris Leslie; Anna L Dodds; Margaret Nutley; Alan Cooper; Christopher Johnson; Paul Thompson; David K Stammers; Alastair R Hawkins
The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
The Journal of biological chemistry 2003;278(34):32107-14.
2003: Katherine A Brown; E P Carpenter; K A Watson; John R Coggins; Alastair R Hawkins; M H J Koch; Dmitri I Svergun
Twists and turns: a tale of two shikimate-pathway enzymes.
Biochemical Society transactions 2003;31(Pt 3):543-7.
2003: Charles E Nichols; Jingshan Ren; Heather K Lamb; Alastair R Hawkins; David K Stammers
Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase.
Journal of molecular biology 2003;327(1):129-44.
2002: Louise Bird; Jingshan Ren; Jiancheng Zhang; Neale Foxwell; Alastair R Hawkins; Ian G Charles; David K Stammers
Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus.
Structure (London, England : 1993) 2002;10(12):1687-96.
2002: Alison Spiers; Heather K Lamb; Simon Cocklin; Kerry A Wheeler; Jo Budworth; Anna L Dodds; Mark J Pallen; Duncan J Maskell; Ian G Charles; Alastair R Hawkins
PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide.
The Journal of biological chemistry 2002;277(42):39443-9.
2002: Carys Watts; Shi Ming Si-Hoe; Heather K Lamb; Lisa J Levett; John R Coggins; Alastair R Hawkins
Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins.
Proteins 2002;48(2):161-8.
2001: David K Stammers; Jingshan Ren; Kris Leslie; Charles E Nichols; Heather K Lamb; Simon Cocklin; Anna L Dodds; Alastair R Hawkins
The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
The EMBO journal 2001;20(23):6619-26.
2001: Charles E Nichols; Simon Cocklin; Anna L Dodds; Jingshan Ren; Heather Lamb; Alastair R Hawkins; David K Stammers
Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1722-5.
2001: Charles E Nichols; Jingshan Ren; Heather Lamb; F Haldane; Alastair R Hawkins; David K Stammers
Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):306-9.
2000: Lisa J Levett; S M Si-Hoe; Stephen T Liddle; K Wheeler; D Smith; Heather K Lamb; G H Newton; John R Coggins; Alastair R Hawkins
Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein.
The Biochemical journal 2000;350 Pt 1():189-97.
2000: Emily J Parker; Concepción González-Bello; John R Coggins; Alastair R Hawkins; Chris Abell
Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids.
Bioorganic & medicinal chemistry letters 2000;10(3):231-4.
1999: David G Gourley; Annette K Shrive; Igor Polikarpov; Tino Krell; John R Coggins; Alastair R Hawkins; N W Isaacs; Lindsay Sawyer
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction.
Nature structural biology 1999;6(6):521-5.
1999: Nicholas C Price; Deborah J Boam; Sharon M Kelly; D Duncan; Tino Krell; David G Gourley; John R Coggins; R Virden; Alastair R Hawkins
The folding and assembly of the dodecameric type II dehydroquinases.
The Biochemical journal 1999;338 ( Pt 1)():195-202.
1998: Kerry A Wheeler; Alastair R Hawkins; RH Pain; R Virden
The slow step of folding of Staphylococcus aureus PC1 beta-lactamase involves the collapse of a surface loop rate limited by the trans to cis isomerization of a non-proline peptide bond.
Proteins 1998;33(4):550-7.
1998: E P Carpenter; Alastair R Hawkins; J W Frost; K A Brown
Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.
Nature 1998;394(6690):299-302.
1997: M A Skinner; A Günel-Ozcan; J Moore; Alastair R Hawkins; Katherine A Brown
Dehydroquinate synthase binds divalent and trivalent cations: role of metal binding in catalysis.
Biochemical Society transactions 1997;25(4):S609.
1997: Heather K Lamb; Anna L Dodds; D R Swatman; E Cairns; Alastair R Hawkins
Deletion of the N-terminal region of the AREA protein is correlated with a derepressed phenotype with respect to nitrogen metabolite repression.
Journal of bacteriology 1997;179(21):6649-56.
1996: J M Harris; C Gonzalez-Bello; Colin Kleanthous; Alastair R Hawkins; J R Coggins; C Abell
Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases.
The Biochemical journal 1996;319 ( Pt 2)():333-6.
1996: J R Bottomley; Alastair R Hawkins; Colin Kleanthous
Conformational changes and the role of metals in the mechanism of type II dehydroquinase from Aspergillus nidulans.
The Biochemical journal 1996;319 ( Pt 1)():269-78.
1996: Heather K Lamb; G H Newton; L J Levett; E Cairns; C F Roberts; Alastair R Hawkins
The QUTA activator and QUTR repressor proteins of Aspergillus nidulans interact to regulate transcription of the quinate utilization pathway genese.
Microbiology (Reading, England) 1996;142 ( Pt 6)():1477-90.
1996: K A Wheeler; Heather K Lamb; Alastair R Hawkins
Control of metabolic flux through the quinate pathway in Aspergillus nidulans.
The Biochemical journal 1996;315 ( Pt 1)():195-205.
1996: Heather K Lamb; J D Moore; J H Lakey; L J Levett; K A Wheeler; H Lago; J R Coggins; Alastair R Hawkins
Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme.
The Biochemical journal 1996;313 ( Pt 3)():941-50.
1996: I Levesley; G H Newton; Heather K Lamb; E van Schothorst; Raymond Dalgleish; A C Samson; C F Roberts; Alastair R Hawkins
Domain structure and function within the QUTA protein of Aspergillus nidulans: implications for the control of transcription.
Microbiology (Reading, England) 1996;142 ( Pt 1)():87-98.
1995: Alastair R Hawkins; Heather K Lamb
The molecular biology of multidomain proteins. Selected examples.
European journal of biochemistry / FEBS 1995;232(1):7-18.
1994: Alastair R Hawkins; Heather K Lamb; A Radford; J D Moore
Evolution of transcription-regulating proteins by enzyme recruitment: molecular models for nitrogen metabolite repression and ethanol utilisation in eukaryotes.
Gene 1994;146(2):145-58.
1994: David G Gourley; John R Coggins; Neil W Isaacs; J D Moore; I G Charles; Alastair R Hawkins
Crystallization of a type II dehydroquinase from Mycobacterium tuberculosis.
Journal of molecular biology 1994;241(3):488-91.
1994: J D Moore; J R Coggins; Richard Virden; Alastair R Hawkins
Efficient independent activity of a monomeric, monofunctional dehydroquinate synthase derived from the N-terminus of the pentafunctional AROM protein of Aspergillus nidulans.
The Biochemical journal 1994;301 ( Pt 1)():297-304.
1994: Alastair R Hawkins; Heather K Lamb; C F Roberts
Control of metabolic flux in the shikimate and quinate pathways.
Progress in industrial microbiology 1994;29():195-220.
1993: Alastair R Hawkins; Heather K Lamb; J D Moore; C F Roberts
Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme.
Gene 1993;136(1-2):49-54.
1993: Alastair R Hawkins; J D Moore; A M Adeokun
Characterization of the 3-dehydroquinase domain of the pentafunctional AROM protein, and the quinate dehydrogenase from Aspergillus nidulans, and the overproduction of the type II 3-dehydroquinase from neurospora crassa.
The Biochemical journal 1993;296 ( Pt 2)():451-7.
1993: Alastair R Hawkins; Heather K Lamb; J D Moore; Ian G Charles; C F Roberts
The pre-chorismate (shikimate) and quinate pathways in filamentous fungi: theoretical and practical aspects.
Journal of general microbiology 1993;139(12):2891-9.
1993: J D Moore; Alastair R Hawkins; Ian G Charles; R Deka; J R Coggins; A Cooper; S M Kelly; N C Price
Characterization of the type I dehydroquinase from Salmonella typhi.
The Biochemical journal 1993;295 ( Pt 1)():277-85.
1993: J D Moore; Alastair R Hawkins
Overproduction of, and interaction within, bifunctional domains from the amino- and carboxy-termini of the pentafunctional AROM protein of Aspergillus nidulans.
Molecular & general genetics : MGG 1993;240(1):92-102.
1993: Alastair R Hawkins; J D Moore; Heather K Lamb
The molecular biology of the pentafunctional AROM protein.
Biochemical Society transactions 1993;21(1):181-6.
1992: J D Moore; Heather K Lamb; T Garbe; S Servos; Gordon Dougan; Ian G Charles; Alastair R Hawkins
Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis.
The Biochemical journal 1992;287 ( Pt 1)():173-81.
1992: C W Boys; S M Bury; Lindsay Sawyer; J D Moore; I G Charles; Alastair R Hawkins; R Deka; Colin Kleanthous; J R Coggins
Crystallization of a type I 3-dehydroquinase from Salmonella typhi.
Journal of molecular biology 1992;227(1):352-5.
1992: J P van den Hombergh; J D Moore; Ian G Charles; Alastair R Hawkins
Overproduction in Escherichia coli of the dehydroquinate synthase domain of the Aspergillus nidulans pentafunctional AROM protein.
The Biochemical journal 1992;284 ( Pt 3)():861-7.
1992: Heather K Lamb; J P van den Hombergh; G H Newton; J D Moore; C F Roberts; Alastair R Hawkins
Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.
The Biochemical journal 1992;284 ( Pt 1)():181-7.
1992: R P Moon; Shiela E Unkles; J M Duncan; Alastair R Hawkins; James R Kinghorn
Sequence of the Phytophthora infestans glyceraldehyde-3-phosphate dehydrogenase-encoding gene (gpdA).
Plant molecular biology 1992;18(6):1209-11.
1992: Colin Kleanthous; R Deka; K Davis; Sharon M Kelly; Alan Cooper; S E Harding; Nicholas C Price; Alastair R Hawkins; John R Coggins
A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes.
The Biochemical journal 1992;282 ( Pt 3)():687-95.
1992: Heather K Lamb; C F Roberts; Alastair R Hawkins
A second gene (qutH) within the Aspergillus nidulans-quinic-acid utilisation gene cluster encodes a protein with a putative zinc-cluster motif.
Gene 1992;112(2):219-24.
1992: Shiela E Unkles; E I Campbell; Peter J Punt; K L Hawker; Roland Contreras; Alastair R Hawkins; Cees A M J J van den Hondel; James R Kinghorn
The Aspergillus niger niaD gene encoding nitrate reductase: upstream nucleotide and amino acid sequence comparisons.
Gene 1992;111(2):149-55.
1992: Alastair R Hawkins; Heather K Lamb; C F Roberts
Structure of the Aspergillus nidulans qut repressor-encoding gene: implications for the regulation of transcription initiation.
Gene 1992;110(1):109-14.
1991: Heather K Lamb; C R Bagshaw; Alastair R Hawkins
In vivo overproduction of the pentafunctional arom polypeptide in Aspergillus nidulans affects metabolic flux in the quinate pathway.
Molecular & general genetics : MGG 1991;227(2):187-96.
1991: Shiela E Unkles; R P Moon; Alastair R Hawkins; J M Duncan; James R Kinghorn
Actin in the oomycetous fungus Phytophthora infestans is the product of several genes.
Gene 1991;100():105-12.
1991: Alastair R Hawkins; M Smith
Domain structure and interaction within the pentafunctional arom polypeptide.
European journal of biochemistry / FEBS 1991;196(3):717-24.
1990: Heather K Lamb; Alastair R Hawkins; M Smith; I J Harvey; J Brown; G Turner; C F Roberts
Spatial and biological characterisation of the complete quinic acid utilisation gene cluster in Aspergillus nidulans.
Molecular & general genetics : MGG 1990;223(1):17-23.
1990: Ian G Charles; Heather K Lamb; Derek Pickard; Gordon Dougan; Alastair R Hawkins
Isolation, characterization and nucleotide sequences of the aroC genes encoding chorismate synthase from Salmonella typhi and Escherichia coli.
Journal of general microbiology 1990;136(2):353-8.
1990: R K Beri; S Grant; C F Roberts; M Smith; Alastair R Hawkins
Selective overexpression of the QUTE gene encoding catabolic 3-dehydroquinase in multicopy transformants of Aspergillus nidulans.
The Biochemical journal 1990;265(2):337-42.
1989: Alastair R Hawkins; S J Gurr; P Montague; James R Kinghorn
Nucleotide sequence and regulation of expression of the Aspergillus nidulans gdhA gene encoding NADP dependent glutamate dehydrogenase.
Molecular & general genetics : MGG 1989;218(1):105-11.
1988: Alastair R Hawkins; Heather K Lamb; M Smith; J W Keyte; C F Roberts
Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.
Molecular & general genetics : MGG 1988;214(2):224-31.
1988: I A Murray; Alastair R Hawkins; J W Keyte; William V Shaw
Nucleotide sequence analysis and overexpression of the gene encoding a type III chloramphenicol acetyltransferase.
The Biochemical journal 1988;252(1):173-9.
1988: S Grant; C F Roberts; H Lamb; M Stout; Alastair R Hawkins
Genetic regulation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans.
Journal of general microbiology 1988;134(2):347-58.
1987: R K Beri; H Whittington; C F Roberts; Alastair R Hawkins
Isolation and characterization of the positively acting regulatory gene QUTA from Aspergillus nidulans.
Nucleic acids research 1987;15(19):7991-8001.
1987: Alastair R Hawkins
The complex Arom locus of Aspergillus nidulans. Evidence for multiple gene fusions and convergent evolution.
Current genetics 1987;11(6-7):491-8.
1987: H A Whittington; S Grant; C F Roberts; H Lamb; Alastair R Hawkins
Identification and isolation of a putative permease gene in the quinic acid utilization (QUT) gene cluster of Aspergillus nidulans.
Current genetics 1987;12(2):135-9.
1986: A J Da Silva; H Whittington; J Clements; C Roberts; Alastair R Hawkins
Sequence analysis and transformation by the catabolic 3-dehydroquinase (QUTE) gene from Aspergillus nidulans.
The Biochemical journal 1986;240(2):481-8.
1986: I G Charles; J W Keyte; William Brammar; M Smith; Alastair R Hawkins
The isolation and nucleotide sequence of the complex AROM locus of Aspergillus nidulans.
Nucleic acids research 1986;14(5):2201-13.
1986: S J Gurr; Alastair R Hawkins; Constantin Drainas; James R Kinghorn
Isolation and identification of the Aspergillus nidulans gdhA gene encoding NADP-linked glutamate dehydrogenase.
Current genetics 1986;10(10):761-6.
1985: I G Charles; J W Keyte; William Brammar; Alastair R Hawkins
Nucleotide sequence encoding the biosynthetic dehydroquinase function of the penta-functional arom locus of Aspergillus nidulans.
Nucleic acids research 1985;13(22):8119-28.
1985: Alastair R Hawkins; A J Francisco Da Silva; C F Roberts
Cloning and characterization of the three enzyme structural genes QUTB, QUTC and QUTE from the quinic acid utilization gene cluster in Aspergillus nidulans.
Current genetics 1985;9(4):305-11.
1985: William V Shaw; D G Brenner; S F LeGrice; S E Skinner; Alastair R Hawkins
Chloramphenicol acetyltransferase gene of staphylococcal plasmid pC221. Nucleotide sequence analysis and expression studies.
FEBS letters 1985;179(1):101-6.
1984: Alastair R Hawkins; A J Francisco da Silva; C F Roberts
Evidence for two control genes regulating expression of the quinic acid utilization (qut) gene cluster in Aspergillus nidulans.
Journal of general microbiology 1984;130(3):567-74.
1982: Alastair R Hawkins; W R Reinert; N H Giles
Characterization of Neurospora crassa catabolic dehydroquinase purified from N. crassa and Escherichia coli.
The Biochemical journal 1982;203(3):769-73.
1982: Alastair R Hawkins; N H Giles; James R Kinghorn
Genetical and biochemical aspects of quinate breakdown in the filamentous fungus Aspergillus nidulans.
Biochemical genetics 1982;20(3-4):271-86.
1982: James R Kinghorn; Alastair R Hawkins
Cloning and expression in Escherichia coli K-12 of the biosynthetic dehydroquinase function of the arom cluster gene from the eucaryote, Aspergillus nidulans.
Molecular & general genetics : MGG 1982;186(1):145-52.