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Meredith Hawkins

Research Profile

Chemicals & Drugs

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Glucose Clamp Technique

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TOP 3
Sudha Koppaka; Do-Eun Lee; Hanna Lee; Weijie Li; Elizabeth Sanchez; Kehao Zhang; Michelle Carey; Emilce Carrasco; Julie Chen; Sylvia Kehlenbrink; Preeti Kishore; Meredith Hawkins
Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans.
Yonah B Esterson; Nir Barzilai; Jill Crandall; Sylvia Kehlenbrink; Preeti Kishore; Sudha Koppaka; Stephanie Lawrence; Do-Eun Lee; Weijie Li; Julia Tonelli; Kehao Zhang; Meredith Hawkins
Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants.
S Kehlenbrink; R Basu; Min-Hui Cui; Meredith Hawkins; Jong-Hee Hwang; S Koppaka; Y Li; M Martin; R Relwani; Preeti Kishore
Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis.

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All Publications

2013: Sudha Koppaka; Do-Eun Lee; Hanna Lee; Weijie Li; Elizabeth Sanchez; Kehao Zhang; Michelle Carey; Emilce Carrasco; Julie Chen; Sylvia Kehlenbrink; Preeti Kishore; Meredith Hawkins
Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans.
Diabetes 2013;62(6):1843-54.
2012: Yonah B Esterson; Nir Barzilai; Jill Crandall; Sylvia Kehlenbrink; Preeti Kishore; Sudha Koppaka; Stephanie Lawrence; Do-Eun Lee; Weijie Li; Julia Tonelli; Kehao Zhang; Meredith Hawkins
Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(12):1321-8.
2012: S Kehlenbrink; R Basu; Min-Hui Cui; Meredith Hawkins; Jong-Hee Hwang; S Koppaka; Y Li; M Martin; R Relwani; Preeti Kishore
Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis.
Diabetologia 2012;55(11):3021-8.
2012: Preeti Kishore; S Koppaka; K Zhang; M R El-Maghrabi; Roger Gutierrez-Juarez; M Hu; S Kehlenbrink; Meredith Hawkins
Xylitol prevents NEFA-induced insulin resistance in rats.
Diabetologia 2012;55(6):1808-12.
2012: Allen Spiegel; Meredith Hawkins
'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?
Health affairs (Project Hope) 2012;31(1):43-9.
2011: Preeti Kishore; Sudha Koppaka; Weijie Li; Deeksha Mehta; Radhika Muzumdar; Anna Schiwek; Gary J Schwartz; Ya Su; Kehao Zhang; Laura Boucai; Samar Bursheh; Yonah B Esterson; Roger Gutierrez-Juarez; Sylvia Kehlenbrink; Meredith Hawkins
Activation of K(ATP) channels suppresses glucose production in humans.
The Journal of clinical investigation 2011;121(12):4916-20.
2011: Daorong Feng; Meredith Hawkins; Richard N Kitsis; Hyok Joon Kwon; Yan Tang; Haihong Zong; Jeffrey Pessin
High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation.
Diabetes 2011;60(8):2134-43.
2010: Pingping Li; Min Lu; M T Audrey Nguyen; Eun Ju Bae; Justin Chapman; Daorong Feng; Meredith Hawkins; Jeffrey Pessin; Dorothy D Sears; Anh-Khoi Nguyen; Arezou Amidi; Steven M Watkins; Uyenthao Nguyen; Jerrold M Olefsky
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice.
The Journal of biological chemistry 2010;285(20):15333-45.
2010: Preeti Kishore; Weijie Li; Julia Tonelli; Do-Eun Lee; Sudha Koppaka; Kehao Zhang; Ying Lin; Sylvia Kehlenbrink; Philipp E Scherer; Meredith Hawkins
Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages.
Science translational medicine 2010;2(20):20ra15.
2009: Sylvia Kehlenbrink; Julia Tonelli; Sudha Koppaka; Visvanathan Chandramouli; Meredith Hawkins; Preeti Kishore
Inhibiting gluconeogenesis prevents fatty acid-induced increases in endogenous glucose production.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E165-73.
2009: Do-Eun Lee; Sylvia Kehlenbrink; Hanna Lee; Meredith Hawkins; John S Yudkin
Getting the message across: mechanisms of physiological cross talk by adipose tissue.
American journal of physiology. Endocrinology and metabolism 2009;296(6):E1210-29.
2008: Todd Schraw; Zhao V Wang; Nils Halberg; Meredith Hawkins; Philipp E Scherer
Plasma adiponectin complexes have distinct biochemical characteristics.
Endocrinology 2008;149(5):2270-82.
2007: Jong-Hee Hwang; Daniel Stein; Nir Barzilai; Min-Hui Cui; Julia Tonelli; Preeti Kishore; Meredith Hawkins
Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1663-9.
2007: Yiwen Peng; D Stewart; Weijie Li; Meredith Hawkins; S Kulak; B Ballermann; Nadia Jahroudi
Irradiation modulates association of NF-Y with histone-modifying cofactors PCAF and HDAC.
Oncogene 2007;26(54):7576-83.
2007: Weijie Li; Julia Tonelli; Preeti Kishore; Randall P Owen; Elliot Goodman; Philipp E Scherer; Meredith Hawkins
Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle.
American journal of physiology. Endocrinology and metabolism 2007;292(5):E1301-7.
2007: Eugene Fine; Do-Eun Lee; Meredith Hawkins
Sweet clarity: less invasive measures of hepatic glucose metabolism.
Gastroenterology 2007;132(2):794-7.
2006: Preeti Kishore; Julia Tonelli; Sudha Koppaka; Corina Fratila; Anita Bose; Do-Eun Lee; Kalpana Reddy; Meredith Hawkins
Time-dependent effects of free fatty acids on glucose effectiveness in type 2 diabetes.
Diabetes 2006;55(6):1761-8.
2006: Thomas S Hermann; Weijie Li; Helena Dominguez; Nikolaj Ihlemann; Christian Rask-Madsen; Atheline Major-Pedersen; Dorthe Baunbjerg Nielsen; Kaj Winther Hansen; Meredith Hawkins; Lars Kober; Christian Torp-Pedersen
Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2006;91(3):1001-8.
2005: Amira Klip; Meredith Hawkins
Desperately seeking sugar: glial cells as hypoglycemia sensors.
The Journal of clinical investigation 2005;115(12):3403-5.
2005: Julia Tonelli; Preeti Kishore; Do-Eun Lee; Meredith Hawkins
The regulation of glucose effectiveness: how glucose modulates its own production.
Current opinion in clinical nutrition and metabolic care 2005;8(4):450-6.
2005: Ying Lin; Anders H Berg; Puneeth Iyengar; Tony K T Lam; Adria Giacca; Terry P Combs; Michael W Rajala; Xue-Liang Du; Brent Rollman; Weijie Li; Meredith Hawkins; Nir Barzilai; Christopher J Rhodes; I George Fantus; Michael Brownlee; Philipp E Scherer
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
The Journal of biological chemistry 2005;280(6):4617-26.
2004: Meredith Hawkins
Markers of increased cardiovascular risk: are we measuring the most appropriate parameters?
Obesity research 2004;12 Suppl 2():107S-14S.
2004: Julia Tonelli; Weijie Li; Preeti Kishore; Utpal B Pajvani; Elize Kwon; Charles Weaver; Philipp E Scherer; Meredith Hawkins
Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes.
Diabetes 2004;53(6):1621-9.
2004: Utpal B Pajvani; Meredith Hawkins; Terry P Combs; Michael W Rajala; Thomas W Doebber; Joel P Berger; John A Wagner; Margaret Wu; Annemie Knopps; Anny H Xiang; Kristina M Utzschneider; Steven E Kahn; Jerrold M Olefsky; Thomas A Buchanan; Philipp E Scherer
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.
The Journal of biological chemistry 2004;279(13):12152-62.
2003: Meredith Hawkins; Julia Tonelli; Preeti Kishore; Daniel Stein; Enzo Ragucci; Alon Gitig; Kalpana Reddy
Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes.
Diabetes 2003;52(11):2748-58.
2003: Weijie Li; Biao Xi; Wancai Yang; Meredith Hawkins; Ulrich Schubart
Complex DNA melting profiles of small PCR products revealed using SYBR Green I.
BioTechniques 2003;35(4):702-4, 706.
2002: Meredith Hawkins; Ilan Gabriely; Robert Wozniak; Kalpana Reddy; Luciano Rossetti; Harry Shamoon
Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects.
Diabetes 2002;51(7):2179-89.
2002: Ilan Gabriely; Meredith Hawkins; Cristian Vilcu; Luciano Rossetti; Harry Shamoon
Fructose amplifies counterregulatory responses to hypoglycemia in humans.
Diabetes 2002;51(4):893-900.
2002: Meredith Hawkins; Ilan Gabriely; Robert Wozniak; Cristian Vilcu; Harry Shamoon; Luciano Rossetti
Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes.
Diabetes 2002;51(3):606-14.
2001: Ilan Gabriely; Robert Wozniak; Meredith Hawkins; Harry Shamoon
Troglitazone amplifies counterregulatory responses to hypoglycemia in nondiabetic subjects.
The Journal of clinical endocrinology and metabolism 2001;86(2):521-8.
1999: Meredith Hawkins; M Hu; J Yu; H Eder; Patricia Vuguin; li she; Nir Barzilai; M Leiser; Jonathan M Backer; Luciano Rossetti
Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity.
The Journal of biological chemistry 1999;274(44):31312-9.
1998: L Liu; George Karkanias; Jose C Morales; Meredith Hawkins; Nir Barzilai; J Wang; Luciano Rossetti
Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes.
The Journal of biological chemistry 1998;273(47):31160-7.
1998: M Mevorach; A Giacca; Y Aharon; Meredith Hawkins; Harry Shamoon; Luciano Rossetti
Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.
The Journal of clinical investigation 1998;102(4):744-53.
1998: J Wang; R Liu; Meredith Hawkins; Nir Barzilai; Luciano Rossetti
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.
Nature 1998;393(6686):684-8.
1998: Nir Barzilai; S Banerjee; Meredith Hawkins; W Chen; Luciano Rossetti
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
The Journal of clinical investigation 1998;101(7):1353-61.
1998: Nir Barzilai; S Banerjee; Meredith Hawkins; C J Chang; W Chen; L Rossetti
The effect of age-dependent increase in fat mass on peripheral insulin action is saturable.
The journals of gerontology. Series A, Biological sciences and medical sciences 1998;53(2):B141-6.
1998: D Massillon; W Chen; Nir Barzilai; D Prus-Wertheimer; Meredith Hawkins; R Liu; R Taub; Luciano Rossetti
Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats.
The Journal of biological chemistry 1998;273(1):228-34.
1997: Nir Barzilai; J Wang; D Massilon; Patricia Vuguin; Meredith Hawkins; Luciano Rossetti
Leptin selectively decreases visceral adiposity and enhances insulin action.
The Journal of clinical investigation 1997;100(12):3105-10.
1997: Luciano Rossetti; D Massillon; Nir Barzilai; Patricia Vuguin; W Chen; Meredith Hawkins; J Wu; J Wang
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action.
The Journal of biological chemistry 1997;272(44):27758-63.
1997: Luciano Rossetti; W Chen; M Hu; Meredith Hawkins; Nir Barzilai; S Efrat
Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
The American journal of physiology 1997;273(4 Pt 1):E743-50.
1997: Meredith Hawkins; Nir Barzilai; R Liu; M Hu; W Chen; Luciano Rossetti
Role of the glucosamine pathway in fat-induced insulin resistance.
The Journal of clinical investigation 1997;99(9):2173-82.
1997: Meredith Hawkins; I Angelov; R Liu; Nir Barzilai; L Rossetti
The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake.
The Journal of biological chemistry 1997;272(8):4889-95.
1997: D Massillon; Nir Barzilai; Meredith Hawkins; D Prus-Wertheimer; Luciano Rossetti
Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion.
Diabetes 1997;46(1):153-7.
1996: Meredith Hawkins; Nir Barzilai; W Chen; I Angelov; M Hu; P Cohen; Luciano Rossetti
Increased hexosamine availability similarly impairs the action of insulin and IGF-1 on glucose disposal.
Diabetes 1996;45(12):1734-43.
1996: Nir Barzilai; Meredith Hawkins; I Angelov; M Hu; Luciano Rossetti
Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.
Diabetes 1996;45(10):1329-35.
1995: D Massillon; W Chen; Meredith Hawkins; R Liu; Nir Barzilai; Luciano Rossetti
Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice.
The American journal of physiology 1995;269(6 Pt 1):E1037-43.
1995: Luciano Rossetti; Meredith Hawkins; W Chen; J Gindi; Nir Barzilai
In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.
The Journal of clinical investigation 1995;96(1):132-40.