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Phillip Hawkins

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Chemicals & Drugs

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Karen E Anderson; Jonathan Clark; Tom N Durrant; Veronique Juvin; Anna Kielkowska; Len R Stephens; Phillip T Hawkins
Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.
Laure Gambardella; Phillip T Hawkins; Zoltán Jakus; Miklós Kovács; Attila Mócsai; Len Stephens; Karen E Anderson; Susann Voigt; Sonja Vermeren
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.
Laure Gambardella; Phillip T Hawkins; Thomas Ludwig; Tânia Margarido; Laura Norton; Claudia Nussbaum; Anne Segonds-Pichon; Markus Sperandio; Len Stephens; Karen E Anderson; Sonja Vermeren
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.

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2013: Karen E Anderson; Jonathan Clark; Tom N Durrant; Veronique Juvin; Anna Kielkowska; Len R Stephens; Phillip T Hawkins
Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.
PloS one 2013;8(3):e58425.
2013: Laure Gambardella; Phillip T Hawkins; Zoltán Jakus; Miklós Kovács; Attila Mócsai; Len Stephens; Karen E Anderson; Susann Voigt; Sonja Vermeren
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):381-91.
2011: Laure Gambardella; Phillip T Hawkins; Thomas Ludwig; Tânia Margarido; Laura Norton; Claudia Nussbaum; Anne Segonds-Pichon; Markus Sperandio; Len Stephens; Karen E Anderson; Sonja Vermeren
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.
Blood 2011;118(4):1087-98.
2011: Jonathan Clark; Karen E Anderson; Veronique Juvin; Trevor S Smith; Fredrik Karpe; Michael J O Wakelam; Len R Stephens; Phillip T Hawkins
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.
Nature methods 2011;8(3):267-72.
2011: Keith B Boyle; David Gyori; Anca Sindrilaru; Karin Scharffetter-Kochanek; Philip R Taylor; Attila Mócsai; Len R Stephens; Phillip T Hawkins
Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2978-89.
2011: Suhasini Kulkarni; Cassian Sitaru; Zoltan Jakus; Karen E Anderson; George Damoulakis; Keith Davidson; Misa Hirose; Jatinder Juss; David Oxley; Tamara A M Chessa; Faruk Ramadani; Herve Guillou; Anne Segonds-Pichon; Anja Fritsch; Gavin E Jarvis; Klaus Okkenhaug; Ralf Ludwig; Detlef Zillikens; Attila Mócsai; Bart Vanhaesebroeck; Len R Stephens; Phillip T Hawkins
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
Science signaling 2011;4(168):ra23.
2010: Tamara A M Chessa; Karen E Anderson; Yanhua Hu; Qingbo Xu; Oliver Rausch; Len R Stephens; Phillip T Hawkins
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood 2010;116(26):6027-36.
2010: Karen E Anderson; Tamara A M Chessa; Keith Davidson; Robert B Henderson; Simon Walker; Tanya Tolmachova; Katarzyna Grys; Oliver Rausch; Miguel C Seabra; Victor L J Tybulewicz; Len R Stephens; Phillip T Hawkins
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.
Blood 2010;116(23):4978-89.
2010: Stuart Conway; James Gardiner; Simon J A Grove; Melloney K Johns; Ze-Yi Lim; GF Painter; Diane E J E Robinson; Christine Schieber; Jan W Thuring; Leon S-M Wong; Meng-Xin Yin; Antony W Burgess; Bruno Catimel; Phillip T Hawkins; Nicholas T Ktistakis; Len R Stephens; Andrew B Holmes
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.
Organic & biomolecular chemistry 2010;8(1):66-76.
2010: Phillip T Hawkins; Len R Stephens; Sabine Suire; Michael Wilson
PI3K signaling in neutrophils.
Current topics in microbiology and immunology 2010;346():183-202.
2008: Karen E Anderson; Keith B Boyle; Keith Davidson; Tamara A M Chessa; Suhasini Kulkarni; Gavin E Jarvis; Anca Sindrilaru; Karin Scharffetter-Kochanek; Oliver Rausch; Len R Stephens; Phillip T Hawkins
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.
Blood 2008;112(13):5202-11.
2007: Simon Andrews; Len R Stephens; Phillip T Hawkins
PI3K class IB pathway in neutrophils.
Science's STKE : signal transduction knowledge environment 2007;2007(407):cm3.
2007: Simon Andrews; Len R Stephens; Phillip T Hawkins
PI3K class IB pathway.
Science's STKE : signal transduction knowledge environment 2007;2007(407):cm2.
2007: Phillip T Hawkins; Len R Stephens
PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis.
Science (New York, N.Y.) 2007;318(5847):64-6.
2007: Varuni Paranavitane; Len R Stephens; Phillip T Hawkins
Structural determinants of LL5beta subcellular localisation and association with filamin C.
Cellular signalling 2007;19(4):817-24.
2007: Hervé Guillou; Charlotte Lécureuil; Karen E Anderson; Sabine Suire; Gordon ferguson; Chris D Ellson; Alexander Gray; Nullin Divecha; Phillip T Hawkins; Len R Stephens
Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach.
Journal of lipid research 2007;48(3):726-32.
2007: Hervé Guillou; Len R Stephens; Phillip T Hawkins
Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate.
Methods in enzymology 2007;434():117-30.
2007: Phillip T Hawkins; Keith Davidson; Len R Stephens
The role of PI3Ks in the regulation of the neutrophil NADPH oxidase.
Biochemical Society symposium 2007;(74):59-67.
2007: Gordon ferguson; Laura Milne; Suhasini Kulkarni; Takehiko Sasaki; Simon Walker; Simon Andrews; Tom Crabbe; Peter Finan; Gareth Jones; Shaun Jackson; Montserrat Camps; Christian Rommel; Matthias P Wymann; Emilio Hirsch; Phillip T Hawkins; Len Stephens
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
Nature cell biology 2007;9(1):86-91.
2006: Phillip T Hawkins; K E Anderson; K Davidson; Len R Stephens
Signalling through Class I PI3Ks in mammalian cells.
Biochemical Society transactions 2006;34(Pt 5):647-62.
2006: Sabine Suire; Alison M Condliffe; Gordon ferguson; Chris D Ellson; Hervé Guillou; Keith Davidson; Heidi Welch; John Coadwell; Martin Turner; Edwin R Chilvers; Phillip T Hawkins; Len Stephens
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.
Nature cell biology 2006;8(11):1303-9.
2006: Chris D Ellson; Keith Davidson; Karen Anderson; Len R Stephens; Phillip T Hawkins
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation.
The EMBO journal 2006;25(19):4468-78.
2006: Chris D Ellson; Keith Davidson; Gordon ferguson; Rod O'Connor; Len R Stephens; Phillip T Hawkins
Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.
The Journal of experimental medicine 2006;203(8):1927-37.
2006: Alison M Condliffe; Louise M C Webb; Gordon ferguson; Keith Davidson; Martin Turner; Elena Vigorito; Maria Manifava; Edwin R Chilvers; Len R Stephens; Phillip T Hawkins
RhoG regulates the neutrophil NADPH oxidase.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5314-20.
2006: Sonja Krugmann; Simon Andrews; Len Stephens; Phillip T Hawkins
ARAP3 is essential for formation of lamellipodia after growth factor stimulation.
Journal of cell science 2006;119(Pt 3):425-32.
2006: Sonja Krugmann; Len Stephens; Phillip T Hawkins
Purification of ARAP3 and characterization of GAP activities.
Methods in enzymology 2006;406():91-103.
2005: Heidi C E Welch; Alison M Condliffe; Laura Milne; Gordon ferguson; Kirsti Hill; Louise M C Webb; Klaus Okkenhaug; W John Coadwell; Simon R Andrews; Marcus Thelen; Gareth E Jones; Phillip T Hawkins; Len R Stephens
P-Rex1 regulates neutrophil function.
Current biology : CB 2005;15(20):1867-73.
2005: Alison M Condliffe; Keith Davidson; Karen E Anderson; Chris D Ellson; Tom Crabbe; Klaus Okkenhaug; Bart Vanhaesebroeck; Martin Turner; Louise Webb; Matthias P Wymann; Emilio Hirsch; Thomas Ruckle; Montserrat Camps; Christian Rommel; Shaun P Jackson; Edwin R Chilvers; Len R Stephens; Phillip T Hawkins
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Blood 2005;106(4):1432-40.
2005: Len Stephens; Roger Williams; Phillip T Hawkins
Phosphoinositide 3-kinases as drug targets in cancer.
Current opinion in pharmacology 2005;5(4):357-65.
2005: Sabine Suire; John Coadwell; Gordon ferguson; Keith Davidson; Phillip T Hawkins; Len Stephens
p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.
Current biology : CB 2005;15(6):566-70.
2005: Kirsti Hill; Sonja Krugmann; Simon R Andrews; W John Coadwell; Peter Finan; Heidi C E Welch; Phillip T Hawkins; Len R Stephens
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.
The Journal of biological chemistry 2005;280(6):4166-73.
2004: Sarah Donald; Kirsti Hill; Charlotte Lecureuil; Romain Barnouin; Sonja Krugmann; W John Coadwell; Simon R Andrews; Simon A Walker; Phillip T Hawkins; Len R Stephens; Heidi C E Welch
P-Rex2, a new guanine-nucleotide exchange factor for Rac.
FEBS letters 2004;572(1-3):172-6.
2004: Sonja Krugmann; Roger Williams; Len Stephens; Phillip T Hawkins
ARAP3 is a PI3K- and rap-regulated GAP for RhoA.
Current biology : CB 2004;14(15):1380-4.
2004: Olga Perisic; Michael I Wilson; Dimitrios Karathanassis; Jerónimo Bravo; Michael E Pacold; Chris D Ellson; Phillip T Hawkins; Len Stephens; Roger L Williams
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.
Advances in enzyme regulation 2004;44():279-98.
2003: Heidi C E Welch; W John Coadwell; Len R Stephens; Phillip T Hawkins
Phosphoinositide 3-kinase-dependent activation of Rac.
FEBS letters 2003;546(1):93-7.
2003: Varuni Paranavitane; W John Coadwell; Alicia Eguinoa; Phillip T Hawkins; Len Stephens
LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin.
The Journal of biological chemistry 2003;278(2):1328-35.
2002: Sabine Suire; Phillip T Hawkins; Len Stephens
Activation of phosphoinositide 3-kinase gamma by Ras.
Current biology : CB 2002;12(13):1068-75.
2002: Len Stephens; Chris D Ellson; Phillip T Hawkins
Roles of PI3Ks in leukocyte chemotaxis and phagocytosis.
Current opinion in cell biology 2002;14(2):203-13.
2002: Heidi C E Welch; W John Coadwell; Chris D Ellson; Gordon ferguson; Simon R Andrews; Hediye Erdjument-Bromage; Paul Tempst; Phillip T Hawkins; Len R Stephens
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.
Cell 2002;108(6):809-21.
2002: Chris D Ellson; Simon Andrews; Len R Stephens; Phillip T Hawkins
The PX domain: a new phosphoinositide-binding module.
Journal of cell science 2002;115(Pt 6):1099-105.
2002: Sonja Krugmann; Matthew A Cooper; Dudley H Williams; Phillip T Hawkins; Len R Stephens
Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits.
The Biochemical journal 2002;362(Pt 3):725-31.
2002: Sonja Krugmann; Karen E Anderson; SH Ridley; N Risso; Alex McGregor; John Coadwell; Keith Davidson; Alicia Eguinoa; Chris D Ellson; Peter Lipp; Maria Manifava; Nicholas T Ktistakis; GF Painter; Jan W Thuring; Matthew A Cooper; Ze-Yi Lim; Andrew B Holmes; Stephen K Dove; Robert H Michell; A Grewal; A Nazarian; Hediye Erdjument-Bromage; Paul Tempst; Len R Stephens; Phillip T Hawkins
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Molecular cell 2002;9(1):95-108.
2001: Len R Stephens; K E Anderson; Phillip T Hawkins
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.
The Journal of biological chemistry 2001;276(46):42767-73.
2001: SH Ridley; Nicholas T Ktistakis; Keith Davidson; Karen E Anderson; Maria Manifava; Chris D Ellson; Peter Lipp; Martin D Bootman; John Coadwell; A Nazarian; Hediye Erdjument-Bromage; Paul Tempst; Matthew A Cooper; Jan W Thuring; Ze-Yi Lim; Andrew B Holmes; Len R Stephens; Phillip T Hawkins
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.
Journal of cell science 2001;114(Pt 22):3991-4000.
2001: Chris D Ellson; Karen E Anderson; G Morgan; Edwin R Chilvers; Peter Lipp; Len R Stephens; Phillip T Hawkins
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.
Current biology : CB 2001;11(20):1631-5.
2001: Jerónimo Bravo; Dimitrios Karathanassis; C M Pacold; Michael E Pacold; Chris D Ellson; Karen E Anderson; P J Butler; I Lavenir; Olga Perisic; Phillip T Hawkins; Len Stephens; Roger L Williams
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
Molecular cell 2001;8(4):829-39.
2001: Chris D Ellson; S Gobert-Gosse; Karen E Anderson; Keith Davidson; Hediye Erdjument-Bromage; Paul Tempst; Jan W Thuring; Matthew A Cooper; Ze-Yi Lim; Andrew B Holmes; PR Gaffney; John Coadwell; Edwin R Chilvers; Phillip T Hawkins; Len R Stephens
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox).
Nature cell biology 2001;3(7):679-82.
2000: Michael E Pacold; Sabine Suire; Olga Perisic; S Lara-Gonzalez; Colin T Davis; EH Walker; Phillip T Hawkins; Len Stephens; John F Eccleston; Roger L Williams
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.
Cell 2000;103(6):931-43.
2000: Karen E Anderson; Peter Lipp; Martin D Bootman; SH Ridley; John Coadwell; L Rönnstrand; Johan Lennartsson; Andrew B Holmes; GF Painter; Jan W Thuring; Ze-Yi Lim; Hediye Erdjument-Bromage; A Grewal; Paul Tempst; Len R Stephens; Phillip T Hawkins
DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation.
Current biology : CB 2000;10(22):1403-12.
2000: EH Walker; Michael E Pacold; Olga Perisic; Len Stephens; Phillip T Hawkins; Matthias P Wymann; Roger L Williams
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
Molecular cell 2000;6(4):909-19.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Y Horie; Kurt Bachmaier; Jimmie E Fata; M Li; Akira Suzuki; Denis Bouchard; Alexandra Ho; Mark Redston; Steven Gallinger; Rama Khokha; Tak W Mak; Phillip T Hawkins; Len Stephens; Stephen W Scherer; May Tsao; Josef M Penninger
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Alison M Condliffe; Phillip T Hawkins
Cell biology. Moving in mysterious ways.
Nature 2000;404(6774):135, 137.
2000: L Wang; Hiroshige Hayashi; Kyoichi Kishi; L Huang; A Hagi; K Tamaoka; Phillip T Hawkins; Yousuke Ebina
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase.
The Biochemical journal 2000;345 Pt 3():543-55.
1999: Sonja Krugmann; Phillip T Hawkins; N Pryer; S Braselmann
Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits.
The Journal of biological chemistry 1999;274(24):17152-8.
1999: W Davis; Len R Stephens; Phillip T Hawkins; J Saklatvala
Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42.
The Biochemical journal 1999;338 ( Pt 2)():387-92.
1998: Alison M Condliffe; Phillip T Hawkins; Len R Stephens; Christopher Haslett; Edwin R Chilvers
Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation.
FEBS letters 1998;439(1-2):147-51.
1998: Karen E Anderson; John Coadwell; Len R Stephens; Phillip T Hawkins
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.
Current biology : CB 1998;8(12):684-91.
1998: Heidi Welch; Alicia Eguinoa; Len R Stephens; Phillip T Hawkins
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway.
The Journal of biological chemistry 1998;273(18):11248-56.
1998: Len Stephens; Karen Anderson; David Stokoe; Hediye Erdjument-Bromage; GF Painter; Andrew B Holmes; PR Gaffney; CB Reese; F McCormick; Paul Tempst; John Coadwell; Phillip T Hawkins
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
Science (New York, N.Y.) 1998;279(5351):710-4.
1997: Z Li; Matthew I Wahl; Alicia Eguinoa; Len R Stephens; Phillip T Hawkins; Owen N Witte
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13820-5.
1997: Sonja Krugmann; Alicia Eguinoa; A H McGregor; Phillip T Hawkins; Len R Stephens
Structural analysis of a novel isoform of phosphoinositide 3OH-kinase.
Biochemical Society transactions 1997;25(4):S604.
1997: Phillip T Hawkins; Heidi Welch; Alex McGregor; Alicia Eguinoa; S Gobert; Sonja Krugmann; Karen Anderson; David Stokoe; Len Stephens
Signalling via phosphoinositide 3OH kinases.
Biochemical Society transactions 1997;25(4):1147-51.
1997: David Stokoe; Len R Stephens; T Copeland; PR Gaffney; CB Reese; GF Painter; Andrew B Holmes; F McCormick; Phillip T Hawkins
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.
Science (New York, N.Y.) 1997;277(5325):567-70.
1997: Len R Stephens; Alicia Eguinoa; Hediye Erdjument-Bromage; M Lui; F Cooke; John Coadwell; A S Smrcka; M Thelen; Karen A Cadwallader; Paul Tempst; Phillip T Hawkins
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.
Cell 1997;89(1):105-14.
1996: R J Walters; Phillip T Hawkins; F T Cooke; Alicia Eguinoa; Len R Stephens
Insulin and ATP stimulate actin polymerization in U937 cells by a wortmannin-sensitive mechanism.
FEBS letters 1996;392(1):66-70.
1996: Len Stephens; Phillip T Hawkins; Alicia Eguinoa; F Cooke
A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):211-5.
1996: Trevor Jackson; Ira J Blader; L P Hammonds-Odie; C R Burga; F Cooke; Phillip T Hawkins; A G Wolf; K A Heldman; Anne Theibert
Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.
Journal of cell science 1996;109 ( Pt 2)():289-300.
1995: Phillip T Hawkins; Alicia Eguinoa; R G Qiu; David Stokoe; F T Cooke; R Walters; S Wennström; Lena Claesson-Welsh; T Evans; Marc Symons
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.
Current biology : CB 1995;5(4):393-403.
1994: Len Stephens; A Smrcka; F T Cooke; Trevor Jackson; Paul C Sternweis; Phillip T Hawkins
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits.
Cell 1994;77(1):83-93.
1994: Len Stephens; F T Cooke; R Walters; T Jackson; Stefano Volinia; Ivan T Gout; M D Waterfield; Phillip T Hawkins
Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells.
Current biology : CB 1994;4(3):203-14.
1993: Len Stephens; Trevor Jackson; Phillip T Hawkins
Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues.
The Biochemical journal 1993;296 ( Pt 2)():481-8.
1993: Len R Stephens; Trevor Jackson; Phillip T Hawkins
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?
Biochimica et biophysica acta 1993;1179(1):27-75.
1993: Phillip T Hawkins; David R Poyner; Trevor Jackson; A J Letcher; D A Lander; Robin F Irvine
Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo-inositol hexakisphosphate.
The Biochemical journal 1993;294 ( Pt 3)():929-34.
1993: Len Stephens; T Jackson; Phillip T Hawkins
Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins.
The Journal of biological chemistry 1993;268(23):17162-72.
1993: Seth J Corey; Alicia Eguinoa; K Puyana-Theall; J B Bolen; L Cantley; Faustino Mollinedo; Trevor Jackson; Phillip T Hawkins; Len R Stephens
Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.
The EMBO journal 1993;12(7):2681-90.
1993: Len Stephens; Alicia Eguinoa; Seth J Corey; T Jackson; Phillip T Hawkins
Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.
The EMBO journal 1993;12(6):2265-73.
1993: David R Poyner; M R Hanley; Trevor Jackson; Phillip T Hawkins
Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-I.
The Biochemical journal 1993;290 ( Pt 3)():901-5.
1993: Len Stephens; T Radenberg; U Thiel; G Vogel; K H Khoo; A Dell; Trevor Jackson; Phillip T Hawkins; G W Mayr
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s).
The Journal of biological chemistry 1993;268(6):4009-15.
1993: Phillip T Hawkins; Len R Stephens; J R Piggott
Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation.
The Journal of biological chemistry 1993;268(5):3374-83.
1993: David R Poyner; F Cooke; M R Hanley; David John Morton Reynolds; Phillip T Hawkins
Characterization of metal ion-induced [3H]inositol hexakisphosphate binding to rat cerebellar membranes.
The Journal of biological chemistry 1993;268(2):1032-8.
1992: Trevor Jackson; Len R Stephens; Phillip T Hawkins
Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells.
The Journal of biological chemistry 1992;267(23):16627-36.
1992: Phillip T Hawkins; Trevor Jackson; Len R Stephens
Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase.
Nature 1992;358(6382):157-9.
1992: A F Stanley; Phillip T Hawkins; David R Poyner; M R Hanley
Metabolism of myo-inositol pentakisphosphates in mammalian brain.
Biochemical Society transactions 1992;20(2):149S.
1992: David R Poyner; Trevor Jackson; Phillip T Hawkins
Stimulation of phosphatidylinositol-3-kinase by insulin-like growth factor 1 and other agonists.
Biochemical Society transactions 1992;20(2):140S.
1991: Len R Stephens; Phillip T Hawkins; A F Stanley; T Moore; David R Poyner; P J Morris; M R Hanley; R R Kay; R F Irvine
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate.
The Biochemical journal 1991;275 ( Pt 2)():485-99.
1991: F Cooke; David R Poyner; Phillip T Hawkins; C B Erlebach; M Hanley
Inositol hexakisphosphate-membranes interactions: the role of metal ions.
Biochemical Society transactions 1991;19(2):152S.
1991: M R Hanley; David R Poyner; Phillip T Hawkins
Inositol phospholipids and phosphates for investigation of intact cell phospholipase C substrates and products.
Methods in enzymology 1991;197():149-58.
1990: David R Poyner; Phillip T Hawkins; H P Benton; M R Hanley
Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli.
The Biochemical journal 1990;271(3):605-11.
1990: ET Ulug; Phillip T Hawkins; M R Hanley; Sara A Courtneidge
Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen.
Journal of virology 1990;64(8):3895-904.
1990: A F Stanley; Phillip T Hawkins; M R Hanley
Inositol hexakisphosphate biosynthesis in mammalian brain: identification of a novel inositol pentakisphosphate kinase.
Biochemical Society transactions 1990;18(3):460-1.
1990: David R Poyner; Phillip T Hawkins; M Hanley
Phosphatidylinositol-3-phosphate and inositol phosphates in mitogenesis.
Biochemical Society transactions 1990;18(3):450-1.
1990: Phillip T Hawkins; David John Morton Reynolds; David R Poyner; M R Hanley
Identification of a novel inositol phosphate recognition site: specific [3H]inositol hexakisphosphate binding to brain regions and cerebellar membranes.
Biochemical and biophysical research communications 1990;167(2):819-27.
1990: M R Hanley; W T Cheung; Phillip T Hawkins; David R Poyner; H P Benton; L Blair; Trevor Jackson; Michel Goedert
The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.
Ciba Foundation symposium 1990;150():23-38; discussion 38-46.
1989: Len R Stephens; Phillip T Hawkins; C P Downes
An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes.
The Biochemical journal 1989;262(3):727-37.
1989: C E King; Phillip T Hawkins; Len R Stephens; Robert H Michell
Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes.
The Biochemical journal 1989;259(3):893-6.
1989: Len Stephens; Phillip T Hawkins; C P Downes
Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate.
The Biochemical journal 1989;259(1):267-76.
1989: C P Berrie; Phillip T Hawkins; Len R Stephens; T Kendall Harden; C P Downes
Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors.
Molecular pharmacology 1989;35(4):526-32.
1989: D Carpenter; M R Hanley; Phillip T Hawkins; Trevor Jackson; Len R Stephens; M Vallejo
The metabolism and functions of inositol pentakisphosphate and inositol hexakisphosphate.
Biochemical Society transactions 1989;17(1):3-5.
1988: Len R Stephens; Phillip T Hawkins; C J Barker; C P Downes
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation.
The Biochemical journal 1988;253(3):721-33.
1988: C P Downes; C P Berrie; Phillip T Hawkins; Len Stephens; José L Boyer; T Kendall Harden
Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;320(1199):267-80.
1988: T Kendall Harden; Phillip T Hawkins; Len Stephens; José L Boyer; C P Downes
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes.
The Biochemical journal 1988;252(2):583-93.
1988: Len Stephens; Phillip T Hawkins; N Carter; S B Chahwala; Andrew J Morris; A D Whetton; P C Downes
L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells.
The Biochemical journal 1988;249(1):271-82.
1988: M R Hanley; Trevor Jackson; W T Cheung; M Dreher; A Gatti; Phillip T Hawkins; S I Patterson; M Vallejo; Alan P Dawson; O Thastrup
Molecular mechanisms of phospholipid signaling pathways in mammalian nerve cells.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():435-45.
1988: Len R Stephens; Phillip T Hawkins; Andrew J Morris; P C Downes
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
The Biochemical journal 1988;249(1):283-92.
1987: T Kendall Harden; Len Stephens; Phillip T Hawkins; C P Downes
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides.
The Journal of biological chemistry 1987;262(19):9057-61.
1987: C E King; Len R Stephens; Phillip T Hawkins; G R Guy; Robert H Michell
Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate.
The Biochemical journal 1987;244(1):209-17.
1987: Phillip T Hawkins; C P Berrie; Andrew J Morris; C P Downes
Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands.
The Biochemical journal 1987;243(1):211-8.
1987: L Best; S Tomlinson; Phillip T Hawkins; C P Downes
Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets.
Biochimica et biophysica acta 1987;927(1):112-6.
1987: Robert H Michell; C E King; G R Guy; Phillip T Hawkins; Len Stephens
Metabolic pooling of inositol lipids in mature erythrocytes and in hormone-stimulated mammalian cells.
Progress in clinical and biological research 1987;249():159-67.
1986: Phillip T Hawkins; Len Stephens; C P Downes
Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate.
The Biochemical journal 1986;238(2):507-16.
1986: S Palmer; Phillip T Hawkins; R H Michell; C J Kirk
The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes.
The Biochemical journal 1986;238(2):491-9.
1986: C P Downes; Phillip T Hawkins; R F Irvine
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.
The Biochemical journal 1986;238(2):501-6.
1984: Phillip T Hawkins; R H Michell; C J Kirk
Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes.
The Biochemical journal 1984;218(3):785-93.
1983: J A Creba; C P Downes; Phillip T Hawkins; G Brewster; R H Michell; C J Kirk
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.
The Biochemical journal 1983;212(3):733-47.
1983: Phillip T Hawkins; R H Michell; C J Kirk
A simple assay method for determination of the specific radioactivity of the gamma-phosphate group of 32P-labelled ATP.
The Biochemical journal 1983;210(3):717-20.
1983: C J Kirk; J A Creba; Phillip T Hawkins; R H Michell
Is vasopressin-stimulated inositol lipid breakdown intrinsic to the mechanism of Ca2+-mobilization at V1 vasopressin receptors?
Progress in brain research 1983;60():405-11.