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Simon Hawley

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D Grahame Hardie; Fiona A Ross; Simon A Hawley
AMP-activated protein kinase: a target for drugs both ancient and modern.
Simon A Hawley; Bruce E Kemp; Kirsty J Mustard; Mark W Peggie; Fiona A Ross; Kei Sakamoto; Jonathan D Schertzer; Gregory R Steinberg; Katherine J Walker; Darya Zibrova; Cyrille Chevtzoff; Morgan D Fullerton; Kevin A Green; D Grahame Hardie
The ancient drug salicylate directly activates AMP-activated protein kinase.
D Grahame Hardie; Fiona A Ross; Simon A Hawley
AMPK: a nutrient and energy sensor that maintains energy homeostasis.

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All Publications

2012: D Grahame Hardie; Fiona A Ross; Simon A Hawley
AMP-activated protein kinase: a target for drugs both ancient and modern.
Chemistry & biology 2012;19(10):1222-36.
2012: Simon A Hawley; Bruce E Kemp; Kirsty J Mustard; Mark W Peggie; Fiona A Ross; Kei Sakamoto; Jonathan D Schertzer; Gregory R Steinberg; Katherine J Walker; Darya Zibrova; Cyrille Chevtzoff; Morgan D Fullerton; Kevin A Green; D Grahame Hardie
The ancient drug salicylate directly activates AMP-activated protein kinase.
Science (New York, N.Y.) 2012;336(6083):918-22.
2012: D Grahame Hardie; Fiona A Ross; Simon A Hawley
AMPK: a nutrient and energy sensor that maintains energy homeostasis.
Nature reviews. Molecular cell biology 2012;13(4):251-62.
2010: Simon A Hawley; Fiona A Ross; Cyrille Chevtzoff; Kevin A Green; Ashleigh Evans; Sarah Fogarty; Mhairi C Towler; Laura J Brown; Oluseye A Ogunbayo; A Mark Evans; D Grahame Hardie
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.
Cell metabolism 2010;11(6):554-65.
2010: Sarah Fogarty; Simon A Hawley; Kevin A Green; Nazan Saner; Kirsty J Mustard; D Grahame Hardie
Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
The Biochemical journal 2010;426(1):109-18.
2008: Mhairi C Towler; Sarah Fogarty; Simon A Hawley; David A Pan; David M A Martin; Nick A Morrice; Afshan McCarthy; María N Galardo; Silvina B Meroni; Selva B Cigorraga; Alan Ashworth; Kei Sakamoto; D Grahame Hardie
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
The Biochemical journal 2008;416(1):1-14.
2007: Olga Göransson; Andrew McBride; Simon A Hawley; Fiona A Ross; Natalia Shpiro; Marc Foretz; Benoit Viollet; D Grahame Hardie; Kei Sakamoto
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
The Journal of biological chemistry 2007;282(45):32549-60.
2007: Richard M Reznick; Haihong Zong; Li Ji; Katsutaro Morino; Irene K Moore; Hannah J Yu; Zhen-Xiang Liu; Jianying Dong; Kirsty J Mustard; Simon A Hawley; Douglas Befroy; Marc Pypaert; D Grahame Hardie; Lawrence H Young; Gerald I Shulman
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.
Cell metabolism 2007;5(2):151-6.
2006: Peter Tamás; Simon A Hawley; Rosemary G Clarke; Kirsty J Mustard; Kevin Green; D Grahame Hardie; Doreen A Cantrell
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.
The Journal of experimental medicine 2006;203(7):1665-70.
2006: D Grahame Hardie; Simon A Hawley; John W Scott
AMP-activated protein kinase--development of the energy sensor concept.
The Journal of physiology 2006;574(Pt 1):7-15.
2005: Simon A Hawley; David A Pan; Kirsty J Mustard; Louise Ross; Jenny Bain; Arthur M Edelman; Bruno G Frenguelli; D Grahame Hardie
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Cell metabolism 2005;2(1):9-19.
2004: Anne E Gadalla; Tim Pearson; Ailsa J Currie; Nicholas Dale; Simon A Hawley; Mike Sheehan; Warren Hirst; Anton D Michel; Andrew Randall; D Grahame Hardie; Bruno G Frenguelli
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.
Journal of neurochemistry 2004;88(5):1272-82.
2004: Jose Lizcano; Olga Göransson; Rachel Toth; Maria Deak; Nick A Morrice; Jérôme Boudeau; Simon A Hawley; Lina Udd; Tomi Mäkelä; D Grahame Hardie; Dario R Alessi
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
The EMBO journal 2004;23(4):833-43.
2004: John W Scott; Simon A Hawley; Kevin A Green; Miliea Anis; Greg Stewart; Gillian A Scullion; David G Norman; D Grahame Hardie
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.
The Journal of clinical investigation 2004;113(2):274-84.
2003: Catherine M Sutherland; Simon A Hawley; Rhonda R McCartney; Anna Leech; Michael J R Stark; Martin C Schmidt; D Grahame Hardie
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.
Current biology : CB 2003;13(15):1299-305.
2003: Emma R Hudson; David A Pan; John James; John M Lucocq; Simon A Hawley; Kevin A Green; Otto Baba; Tatsuo Terashima; D Grahame Hardie
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.
Current biology : CB 2003;13(10):861-6.
2003: Simon A Hawley; Jérôme Boudeau; Jennifer L Reid; Kirsty J Mustard; Lina Udd; Tomi Mäkelä; Dario R Alessi; D Grahame Hardie
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Journal of biology 2003;2(4):28.
2002: Simon A Hawley; Anne E Gadalla; Grith S Olsen; D Grahame Hardie
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.
Diabetes 2002;51(8):2420-5.
2002: John W Scott; David G Norman; Simon A Hawley; Luke Kontogiannis; D Grahame Hardie
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.
Journal of molecular biology 2002;317(2):309-23.
1999: D Grahame Hardie; IP Salt; Simon A Hawley; SP Davies
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.
The Biochemical journal 1999;338 ( Pt 3)():717-22.
1998: IP Salt; J W Celler; Simon A Hawley; Alan R Prescott; A Woods; D Carling; D Grahame Hardie
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.
The Biochemical journal 1998;334 ( Pt 1)():177-87.
1997: D Grahame Hardie; J Corton; Y P Ching; SP Davies; Simon A Hawley
Regulation of lipid metabolism by the AMP-activated protein kinase.
Biochemical Society transactions 1997;25(4):1229-31.
1996: Simon A Hawley; M Davison; A Woods; SP Davies; R K Beri; David Carling; D Grahame Hardie
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.
The Journal of biological chemistry 1996;271(44):27879-87.
1995: Simon A Hawley; M A Selbert; E G Goldstein; Arthur M Edelman; David Carling; D Grahame Hardie
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.
The Journal of biological chemistry 1995;270(45):27186-91.
1995: J M Corton; J G Gillespie; Simon A Hawley; D Grahame Hardie
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
European journal of biochemistry / FEBS 1995;229(2):558-65.
1995: A J Verhoeven; A Woods; C H Brennan; Simon A Hawley; D Grahame Hardie; James Scott; R K Beri; David Carling
The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA.
European journal of biochemistry / FEBS 1995;228(2):236-43.
1994: SP Davies; Simon A Hawley; A Woods; David Carling; T A Haystead; D Grahame Hardie
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.
European journal of biochemistry / FEBS 1994;223(2):351-7.
1994: J Weekes; Simon A Hawley; J Corton; D Shugar; D Grahame Hardie
Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.
European journal of biochemistry / FEBS 1994;219(3):751-7.