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Nissim Hay

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TOP 3
Nahum Sonenberg; Nissim Hay
Cancer genomics: the post-transcriptional era.
Benjamin N Gantner; Nissim Hay; Bin He; Huali Jin; Feng Qian; Richard D Ye
The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.
Kelly A O'Brien; T Kent Gartner; Nissim Hay; Xiaoping Du
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.

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All Publications

2013: Nahum Sonenberg; Nissim Hay
Cancer genomics: the post-transcriptional era.
Current opinion in genetics & development 2013;23(1):1-2.
2012: Benjamin N Gantner; Nissim Hay; Bin He; Huali Jin; Feng Qian; Richard D Ye
The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):3104-11.
2012: Kelly A O'Brien; T Kent Gartner; Nissim Hay; Xiaoping Du
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(9):2232-40.
2012: Liang Ding; Maria Febbraio; Nissim Hay; Richard E Morton; Sudipta Biswas; Tatiana V Byzova; Jonathan D Smith; Eugene A Podrez
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Cell metabolism 2012;15(6):861-72.
2012: Sang-Min Jeon; Navdeep S Chandel; Nissim Hay
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.
Nature 2012;485(7400):661-5.
2012: Nava Segev; Nissim Hay
Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1.
Molecular cell 2012;46(1):4-6.
2012: Veronique Nogueira; Xiao-ding Peng; Neha Sarvepalli; Nahum Sonenberg; Deepa Sundararajan; Jennifer M Kwan; Nissim Hay
Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis.
The EMBO journal 2012;31(5):1134-46.
2012: Pei-Zhang Xu; Mei-Ling Chen; S-M Jeon; Xiao-ding Peng; Nissim Hay
The effect Akt2 deletion on tumor development in Pten(+/-) mice.
Oncogene 2012;31(4):518-26.
2011: Guri Tzivion; Nissim Hay
PI3K-AKT-FoxO axis in cancer and aging.
Biochimica et biophysica acta 2011;1813(11):1925.
2011: Nissim Hay
Interplay between FOXO, TOR, and Akt.
Biochimica et biophysica acta 2011;1813(11):1965-70.
2011: Kelly A O'Brien; Aleksandra Stojanovic-Terpo; Nissim Hay; Xiaoping Du
An important role for Akt3 in platelet activation and thrombosis.
Blood 2011;118(15):4215-23.
2011: Raelene Endersby; Nissim Hay; Xiaoyan Zhu; David W Ellison; Suzanne J Baker
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.
Cancer research 2011;71(12):4106-16.
2011: Nissim Hay
Akt isoforms and glucose homeostasis - the leptin connection.
Trends in endocrinology and metabolism: TEM 2011;22(2):66-73.
2011: Hyun Jung Park; Galina Gusarova; Zebin Wang; Janai R Carr; Jing Li; Ki-Hyun Kim; Jin Qiu; Yoon-Dong Park; Peter R Williamson; Nissim Hay; Angela L Tyner; Lester F Lau; Robert H Costa; Pradip Raychaudhuri
Deregulation of FoxM1b leads to tumour metastasis.
EMBO molecular medicine 2011;3(1):21-34.
2010: Jennifer Woodard; Sonali Joshi; Benoit Viollet; Nissim Hay; Leonidas C Platanias
AMPK as a therapeutic target in renal cell carcinoma.
Cancer biology & therapy 2010;10(11):1168-77.
2010: Nissim Hay
Mnk earmarks eIF4E for cancer therapy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):13975-6.
2010: Ivana Tonic; Wan-Ni Yu; Youngku Park; Chia-Chen Chen; Nissim Hay
Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci.
The Journal of biological chemistry 2010;285(31):23790-8.
2010: Peifeng Li; Shankar Jayarama; Lakshmy Ganesh; David Mordi; Ryan Carr; Prasad Vk Kanteti; Nissim Hay; Bellur S Prabhakar
Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.
The Journal of biological chemistry 2010;285(29):22713-22.
2010: Jia Chen; Hai Yang Tang; Nissim Hay; Jingsong Xu; Richard D Ye
Akt isoforms differentially regulate neutrophil functions.
Blood 2010;115(21):4237-46.
2010: Chia-Chen Chen; Sang-Min Jeon; Prashanth T Bhaskar; Veronique Nogueira; Deepa Sundararajan; Ivana Tonic; Youngkyu Park; Nissim Hay
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Developmental cell 2010;18(4):592-604.
2010: Zhiwei Wang; Yiwei Li; Sanjeev Banerjee; Dejuan Kong; Aamir Ahmad; Veronique Nogueira; Nissim Hay; Asfar S Azmi
Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways.
Journal of cellular biochemistry 2010;109(4):726-36.
2009: Hyun Jung Park; Janai R Carr; Zebin Wang; Veronique Nogueira; Nissim Hay; Angela L Tyner; Lester F Lau; Robert H Costa; Pradip Raychaudhuri
FoxM1, a critical regulator of oxidative stress during oncogenesis.
The EMBO journal 2009;28(19):2908-18.
2009: Prashanth T Bhaskar; Veronique Nogueira; Krushna C Patra; Sang-Min Jeon; Youngkyu Park; R Brooks Robey; Nissim Hay
mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
Molecular and cellular biology 2009;29(18):5136-47.
2009: William S Chen; Xiao-ding Peng; Yong Wang; Pei-Zhang Xu; Mei-Ling Chen; Yongmei Luo; Sang-Min Jeon; Kevin Coleman; Wanda M Haschek; Joseph Bass; Louis H Philipson; Nissim Hay
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.
Molecular and cellular biology 2009;29(11):3151-62.
2009: Mohd Minhajuddin; Kaiser M Bijli; Fabeha Fazal; Antonella Sassano; Keiichi I Nakayama; Nissim Hay; Leonidas C Platanias; Arshad Rahman
Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.
The Journal of biological chemistry 2009;284(7):4052-61.
2009: R Brooks Robey; Nissim Hay
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.
Seminars in cancer biology 2009;19(1):25-31.
2008: Veronique Nogueira; Youngkyu Park; Chia-Chen Chen; Pei-Zhang Xu; Mei-Ling Chen; Ivana Tonic; Terry G Unterman; Nissim Hay
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis.
Cancer cell 2008;14(6):458-70.
2008: Nissim Hay
p53 strikes mTORC1 by employing sestrins.
Cell metabolism 2008;8(3):184-5.
2008: Jennifer Woodard; Antonella Sassano; Nissim Hay; Leonidas C Platanias
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4640-9.
2008: Padma Kannan-Thulasiraman; Blazej Dolniak; Surinder Kaur; Antonella Sassano; Dhan V Kalvakolanu; Nissim Hay; Leonidas C Platanias
Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids.
Biochemical and biophysical research communications 2008;368(4):983-9.
2008: Surinder Kaur; Antonella Sassano; Blazej Dolniak; Sonali Joshi; Beata Majchrzak-Kita; Darren P Baker; Nissim Hay; Eleanor N Fish; Leonidas C Platanias
Role of the Akt pathway in mRNA translation of interferon-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4808-13.
2008: Scott J Cotler; Nissim Hay; Hui Xie; Mei-Ling Chen; Pei-Zhang Xu; Thomas J Layden; Grace Guzman-Hartman
Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease.
Digestive diseases and sciences 2008;53(3):844-9.
2008: Jessica K Altman; Patrick Yoon; Efstratios Katsoulidis; Barbara Kroczynska; Antonella Sassano; Amanda J Redig; Heather Glaser; Alison Jordan; Martin S Tallman; Nissim Hay; Leonidas C Platanias
Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses.
The Journal of biological chemistry 2008;283(4):1992-2001.
2008: Hong Yin; Aleksandra Stojanovic; Nissim Hay; Xiaoping Du
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation.
Blood 2008;111(2):658-65.
2007: Somanath Shenoy; Eugene S Kandel; Nissim Hay; Tatiana V Byzova
Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
The Journal of biological chemistry 2007;282(31):22964-76.
2007: Xiaoming Ju; SANJAY kATIYAR; Chenguang Wang; Manran Liu; Xuanmao Jiao; Shengwen Li; Jie Zhou; Jacob Turner; Michael P Lisanti; R Graham G Russell; Susette C Mueller; John Ojeifo; William S Chen; Nissim Hay; Richard G Pestell
Akt1 governs breast cancer progression in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7438-43.
2007: Prashanth T Bhaskar; Nissim Hay
The two TORCs and Akt.
Developmental cell 2007;12(4):487-502.
2007: Surinder Kaur; Lakhvir Lal; Antonella Sassano; Beata Majchrzak-Kita; Maya Srikanth; Darren P Baker; Emmanuel Petroulakis; Nissim Hay; Nahum Sonenberg; Eleanor N Fish; Leonidas C Platanias
Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling.
The Journal of biological chemistry 2007;282(3):1757-68.
2007: Naohiro Kawamura; Fumitaka Kugimiya; Yasushi Oshima; Shinsuke Ohba; Toshiyuki Ikeda; Taku Saito; Yusuke Shinoda; Yosuke Kawasaki; Naoshi Ogata; Kazuto Hoshi; Toru Akiyama; William S Chen; Nissim Hay; Kazuyuki Tobe; Takashi Kadowaki; Yoshiaki Azuma; Sakae Tanaka; Kozo Nakamura; Ung-il Chung; Hiroshi Kawaguchi
Akt1 in osteoblasts and osteoclasts controls bone remodeling.
PloS one 2007;2(10):e1058.
2006: Jennifer E Skeen; Prashanth T Bhaskar; Chia-Chen Chen; William S Chen; Xiao-ding Peng; Veronique Nogueira; Annett Hahn-Windgassen; Hiroaki Kiyokawa; Nissim Hay
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.
Cancer cell 2006;10(4):269-80.
2006: R B Robey; Nissim Hay
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.
Oncogene 2006;25(34):4683-96.
2006: Aleksandra Stojanovic; Jasna A Marjanovic; Viktor Brovkovych; Xiao-ding Peng; Nissim Hay; Randal A Skidgel; Xiaoping Du
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation.
The Journal of biological chemistry 2006;281(24):16333-9.
2006: Mei-Ling Chen; Pei-Zhang Xu; Xiao-ding Peng; William S Chen; Grace Guzman-Hartman; Ximing Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Nissim Hay
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Genes & development 2006;20(12):1569-74.
2005: Viktor Todorovic; Chih-Chiun Chen; Nissim Hay; Lester F Lau
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts.
The Journal of cell biology 2005;171(3):559-68.
2005: Juhua Chen; Somanath Shenoy; Olga V Razorenova; William S Chen; Nissim Hay; Paul Bornstein; Tatiana V Byzova
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Nature medicine 2005;11(11):1188-96.
2005: Annett Hahn-Windgassen; Veronique Nogueira; Chia-Chen Chen; Jennifer E Skeen; Nahum Sonenberg; Nissim Hay
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.
The Journal of biological chemistry 2005;280(37):32081-9.
2005: Nissim Hay
The Akt-mTOR tango and its relevance to cancer.
Cancer cell 2005;8(3):179-83.
2005: R Brooks Robey; Nissim Hay
Mitochondrial hexokinases: guardians of the mitochondria.
Cell cycle (Georgetown, Tex.) 2005;4(5):654-8.
2005: Yan M Li; Binhua P Zhou; Jiong Deng; Yong Pan; Nissim Hay; Mien-Chie Hung
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Cancer research 2005;65(8):3257-63.
2005: Lakhvir Lal; Yongzhong Li; Jessica Smith; Antonella Sassano; Shahab Uddin; Simrit Parmar; Martin S Tallman; Saverio Minucci; Nissim Hay; Leonidas C Platanias
Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells.
Blood 2005;105(4):1669-77.
2004: Nathan Majewski; Veronique Nogueira; Prashanth T Bhaskar; Platina E Coy; Jennifer E Skeen; Kathrin Gottlob; Navdeep S Chandel; Craig Thompson; R Brooks Robey; Nissim Hay
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.
Molecular cell 2004;16(5):819-30.
2004: Juhua Chen; Sarmishtha De; Derek S Damron; William S Chen; Nissim Hay; Tatiana V Byzova
Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice.
Blood 2004;104(6):1703-10.
2004: Abhishek Datta; Alo Nag; Wei Pan; Nissim Hay; Andrei L Gartel; Oscar R Colamonici; Yasuji Mori; Pradip Raychaudhuri
Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.
The Journal of biological chemistry 2004;279(35):36698-707.
2004: Nissim Hay; Nahum Sonenberg
Upstream and downstream of mTOR.
Genes & development 2004;18(16):1926-45.
2004: Frank W King; Jennifer E Skeen; Nissim Hay; Emma Shtivelman
Inhibition of Chk1 by activated PKB/Akt.
Cell cycle (Georgetown, Tex.) 2004;3(5):634-7.
2004: Fatima Lekmine; Antonella Sassano; Shahab Uddin; Jessica Smith; Beata Majchrzak; Saskia M Brachmann; Nissim Hay; Eleanor N Fish; Leonidas C Platanias
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.
Experimental cell research 2004;295(1):173-82.
2004: Joslyn K Brunelle; Matthew T Santore; G R Scott Budinger; Yueming Tang; Terrence Anthony Barrett; Wei-Xing Zong; Eugene Kandel; Brian Keith; M Celeste Simon; Craig Thompson; Nissim Hay; Navdeep S Chandel
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.
The Journal of biological chemistry 2004;279(6):4305-12.
2004: Nathan Majewski; Veronique Nogueira; R Brooks Robey; Nissim Hay
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases.
Molecular and cellular biology 2004;24(2):730-40.
2003: Francesca Zazzeroni; Salvatore Papa; Alicia Algeciras-Schimnich; Kellean Alvarez; Tiziana Melis; Concetta Bubici; Nathan Majewski; Nissim Hay; enrico de smaele; Marcus E Peter; Guido Franzoso
Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis.
Blood 2003;102(9):3270-9.
2003: Fatima Lekmine; Shahab Uddin; Antonella Sassano; Simrit Parmar; Saskia M Brachmann; Beata Majchrzak; Nahum Sonenberg; Nissim Hay; Eleanor N Fish; Leonidas C Platanias
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.
The Journal of biological chemistry 2003;278(30):27772-80.
2003: Xiao-ding Peng; Pei-Zhang Xu; Mei-Ling Chen; Annett Hahn-Windgassen; Jennifer E Skeen; Joel Jacobs; Deepa Sundararajan; William S Chen; Susan E Crawford; Kevin G Coleman; Nissim Hay
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.
Genes & development 2003;17(11):1352-65.
2002: Eugene S Kandel; Jennifer E Skeen; Nathan Majewski; Antonio Di Cristofano; Pier Paolo Pandolfi; Claudine S Feliciano; Andrei L Gartel; Nissim Hay
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Molecular and cellular biology 2002;22(22):7831-41.
2002: Jane M Bryson; Platina E Coy; Kathrin Gottlob; Nissim Hay; R Brooks Robey
Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death.
The Journal of biological chemistry 2002;277(13):11392-400.
2002: David S McClintock; Matthew T Santore; Vivian Y Lee; Joslyn K Brunelle; G R Scott Budinger; Wei-Xing Zong; Craig Thompson; Nissim Hay; Navdeep S Chandel
Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death.
Molecular and cellular biology 2002;22(1):94-104.
2001: William S Chen; Pei-Zhang Xu; Kathrin Gottlob; Mei-Ling Chen; K Sokol; T Shiyanova; I Roninson; W Weng; R Suzuki; K Tobe; T Kadowaki; Nissim Hay
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.
Genes & development 2001;15(17):2203-8.
2001: M Wert; S Kennedy; H Clive Palfrey; Nissim Hay
Myc drives apoptosis in PC12 cells in the absence of Max.
Oncogene 2001;20(28):3746-50.
2001: Kathrin Gottlob; Nathan Majewski; S Kennedy; Eugene S Kandel; R Brooks Robey; Nissim Hay
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase.
Genes & development 2001;15(11):1406-18.
2001: Andrei L Gartel; X Ye; E Goufman; P Shianov; Nissim Hay; Feridoon Najmabadi; Angela L Tyner
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4510-5.
2001: John M Kokontis; Andrew J Wagner; Maura O'Leary; Shutsung Liao; Nissim Hay
A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function.
Oncogene 2001;20(6):659-68.
2000: P Xie; Darren Browning; Nissim Hay; Nigel Mackman; Richard D Ye
Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt.
The Journal of biological chemistry 2000;275(32):24907-14.
2000: Suzanne D Conzen; Kathrin Gottlob; Eugene S Kandel; P Khanduri; Andrew J Wagner; Maura O'Leary; Nissim Hay
Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis.
Molecular and cellular biology 2000;20(16):6008-18.
1999: E S Kandel; Nissim Hay
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.
Experimental cell research 1999;253(1):210-29.
1999: SG Kennedy; Eugene S Kandel; T K Cross; Nissim Hay
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria.
Molecular and cellular biology 1999;19(8):5800-10.
1999: CC Weihl; Ghanashyam D Ghadge; SG Kennedy; Nissim Hay; Richard J Miller; Raymond P Roos
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(13):5360-9.
1998: John M Kokontis; Nissim Hay; Shutsung Liao
Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest.
Molecular endocrinology (Baltimore, Md.) 1998;12(7):941-53.
1998: Eva M Eves; Wencheng Xiong; A Bellacosa; SG Kennedy; Philip Tsichlis; Marsha Rich Rosner; Nissim Hay
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
Molecular and cellular biology 1998;18(4):2143-52.
1998: Anne-Claude Gingras; SG Kennedy; M A O'Leary; Nahum Sonenberg; Nissim Hay
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.
Genes & development 1998;12(4):502-13.
1997: Mahesh P Gupta; C S Amin; Madhu Gupta; Nissim Hay; R Zak
Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression.
Molecular and cellular biology 1997;17(7):3924-36.
1997: SG Kennedy; Andrew J Wagner; Suzanne D Conzen; Joaquín Jordán; A Bellacosa; Philip Tsichlis; Nissim Hay
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
Genes & development 1997;11(6):701-13.
1996: Eva M Eves; Lawrence Boise; Craig Thompson; A J Wagner; Nissim Hay; Marsha Rich Rosner
Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
Journal of neurochemistry 1996;67(5):1908-20.
1996: J Xu; S Kim; M Chen; S Rockow; S E Yi; A J Wagner; Nissim Hay; R R Weichselbaum; Wenhui Li
Retraction. Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1.
Blood 1996;88(3):1133.
1996: E J Uhlmann; C D'Sa-Eipper; Thirugnana Subramanian; A J Wagner; Nissim Hay; Govindaswamy Chinnadurai
Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation.
Cancer research 1996;56(11):2506-9.
1996: P Shiyanov; Srilata Bagchi; Guy R Adami; John M Kokontis; Nissim Hay; M Arroyo; A Morozov; Pradip Raychaudhuri
p21 Disrupts the interaction between cdk2 and the E2F-p130 complex.
Molecular and cellular biology 1996;16(3):737-44.
1995: J Xu; S Kim; Mei Chen; S Rockow; S E Yi; A J Wagner; Nissim Hay; R R Weichselbaum; Wenhui Li
Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1.
Blood 1995;86(7):2774-88.
1994: A J Wagner; John M Kokontis; Nissim Hay
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
Genes & development 1994;8(23):2817-30.
1994: John M Kokontis; K Takakura; Nissim Hay; Shutsung Liao
Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation.
Cancer research 1994;54(6):1566-73.
1993: A J Wagner; C Meyers; Laimonis A Laimins; Nissim Hay
c-Myc induces the expression and activity of ornithine decarboxylase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(11):879-83.
1993: E DesJardins; Nissim Hay
Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters.
Molecular and cellular biology 1993;13(9):5710-24.
1993: A J Wagner; M B Small; Nissim Hay
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.
Molecular and cellular biology 1993;13(4):2432-40.
1993: C Amin; A J Wagner; Nissim Hay
Sequence-specific transcriptional activation by Myc and repression by Max.
Molecular and cellular biology 1993;13(1):383-90.
1992: A J Wagner; Michelle M Le Beau; Manuel O Diaz; Nissim Hay
Expression, regulation, and chromosomal localization of the Max gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3111-5.
1989: Nissim Hay; M Takimoto; John M Bishop
A FOS protein is present in a complex that binds a negative regulator of MYC.
Genes & development 1989;3(3):293-303.
1988: O Resnekov; E Ben-Asher; E Bengal; Mordechai Choder; Nissim Hay; M Kessler; N Ragimov; M Seiberg; H Skolnik-David; Y Aloni
Transcription termination in animal viruses and cells.
Gene 1988;72(1-2):91-104.
1987: Nissim Hay; John M Bishop; D Levens
Regulatory elements that modulate expression of human c-myc.
Genes & development 1987;1(7):659-71.
1987: M B Small; Nissim Hay; M Schwab; John M Bishop
Neoplastic transformation by the human gene N-myc.
Molecular and cellular biology 1987;7(5):1638-45.
1986: C C Huang; Nissim Hay; John M Bishop
The role of RNA molecules in transduction of the proto-oncogene c-fps.
Cell 1986;44(6):935-40.
1986: Nissim Hay; O Amster-Choder; Y Aloni
Efficient and accurate in vitro processing of simian virus 40-associated small RNA.
Journal of virology 1986;57(1):402-7.
1985: Nissim Hay; Y Aloni
Attenuation of late simian virus 40 mRNA synthesis is enhanced by the agnoprotein and is temporally regulated in isolated nuclear systems.
Molecular and cellular biology 1985;5(6):1327-34.
1985: Y Aloni; Nissim Hay
Attenuation may regulate gene expression in animal viruses and cells.
CRC critical reviews in biochemistry 1985;18(4):327-83.
1984: Nissim Hay; M Kessler; Y Aloni
SV40 deletion mutant (d1861) with agnoprotein shortened by four amino acids.
Virology 1984;137(1):160-70.
1984: Nissim Hay; Y Aloni
Attenuation in SV40 as a mechanism of transcription-termination by RNA polymerase B.
Nucleic acids research 1984;12(3):1401-14.
1984: R Abulafia; A Ben-Ze'ev; Nissim Hay; Y Aloni
Control of late simian virus 40 transcription by the attenuation mechanism and transcriptionally active ternary complexes are associated with the nuclear matrix.
Journal of molecular biology 1984;172(4):467-87.
1983: Y Aloni; Nissim Hay
Attenuation and modulation of mRNA secondary structure in a feedback control system regulating SV40 gene expression.
Molecular biology reports 1983;9(1-2):91-100.
1983: P Pfeiffer; Nissim Hay; R Pruzan; E B Jakobovits; Y Aloni
In vitro premature termination in SV40 late transcription.
The EMBO journal 1983;2(2):185-91.
1982: Nissim Hay; H Skolnik-David; Y Aloni
Attenuation in the control of SV40 gene expression.
Cell 1982;29(1):183-93.
1982: H Skolnik-David; Nissim Hay; Y Aloni
Site of premature termination of late transcription of simian virus 40 DNA: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(9):2743-7.