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Takao Hayakawa

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TOP 3
Kazuo Takayama; Katsuhisa Tashiro; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Miho Kusuda Furue; Takao Hayakawa; Katsuhiro Kanda; Kenji Kawabata; Keisuke Kishimoto; Hiroyuki Mizuguchi
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
Kazuo Takayama; Katsuhisa Tashiro; Hitoshi Watanabe; Yasuhito Nagamoto; Fuminori Sakurai; Michiko Sugawara; Miho Kusuda Furue; Takao Hayakawa; Maiko Higuchi; Mitsuru Inamura; Kenji Kawabata; Kiyomi Kikuchi; Hiroyuki Mizuguchi
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.
Yasuhito Nagamoto; Kazuo Ohashi; Fuminori Sakurai; Masashi Tachibana; Kazuo Takayama; Katsuhisa Tashiro; Miho Kusuda Furue; Takao Hayakawa; Kenji Kawabata; Hiroyuki Mizuguchi
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets.

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All Publications

2013: Kazuo Takayama; Katsuhisa Tashiro; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Miho Kusuda Furue; Takao Hayakawa; Katsuhiro Kanda; Kenji Kawabata; Keisuke Kishimoto; Hiroyuki Mizuguchi
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
Biomaterials 2013;34(7):1781-9.
2012: Kazuo Takayama; Katsuhisa Tashiro; Hitoshi Watanabe; Yasuhito Nagamoto; Fuminori Sakurai; Michiko Sugawara; Miho Kusuda Furue; Takao Hayakawa; Maiko Higuchi; Mitsuru Inamura; Kenji Kawabata; Kiyomi Kikuchi; Hiroyuki Mizuguchi
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.
Journal of hepatology 2012;57(3):628-36.
2012: Yasuhito Nagamoto; Kazuo Ohashi; Fuminori Sakurai; Masashi Tachibana; Kazuo Takayama; Katsuhisa Tashiro; Miho Kusuda Furue; Takao Hayakawa; Kenji Kawabata; Hiroyuki Mizuguchi
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets.
Biomaterials 2012;33(18):4526-34.
2011: Satoshi Yasuda; Tetsuya Hasegawa; Takao Hayakawa; Tetsuji Hosono; Kageyoshi Ono; Mitsutoshi Satoh; Shunichi Shimizu; Kazuhiro Suzuki; Kei Watanabe; Teruhide Yamaguchi; Yoji Sato
AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells.
The Biochemical journal 2011;437(2):345-55.
2011: Takayuki Suzuki; Tomomi Sasaki; Koyori Yano; Fuminori Sakurai; Kenji Kawabata; Masuo Kondoh; Takao Hayakawa; Kiyohito Yagi; Hiroyuki Mizuguchi
Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome.
Virus research 2011;158(1-2):154-60.
2011: Kumiko Sugio; Katsuhisa Tashiro; Fuminori Sakurai; Toshiyoshi Fujiwara; Takao Hayakawa; Masahiro Iwaki; Kazufumi Katayama; Kenji Kawabata; Atsushi Kawase; Hayato Matsui; Hiroyuki Mizuguchi
Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2807-18.
2011: Mitsuru Inamura; Kenji Kawabata; Kazuo Takayama; Katsuhisa Tashiro; Fuminori Sakurai; Kazufumi Katayama; Masashi Toyoda; Hidenori Akutsu; Yoshitaka Miyagawa; Hajime Okita; Nobutaka Kiyokawa; Akihiro Umezawa; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(2):400-7.
2010: Fuminori Sakurai; Kazuko Nakashima; Tomoko Yamaguchi; Takako Ichinose; Kenji Kawabata; Takao Hayakawa; Hiroyuki Mizuguchi
Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(2):212-8.
2009: Katsuhisa Tashiro; Mitsuru Inamura; Kenji Kawabata; Fuminori Sakurai; Koichi Yamanishi; Takao Hayakawa; Hiroyuki Mizuguchi
Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction.
Stem cells (Dayton, Ohio) 2009;27(8):1802-11.
2009: Fuminori Sakurai; S-i Nakamura; K Akitomo; H Shibata; K Terao; Kenji Kawabata; Takao Hayakawa; Hiroyuki Mizuguchi
Adenovirus serotype 35 vector-mediated transduction following direct administration into organs of nonhuman primates.
Gene therapy 2009;16(2):297-302.
2009: Katsuhisa Tashiro; Asami Kondo; Kenji Kawabata; Haruna Sakurai; Fuminori Sakurai; Koichi Yamanishi; Takao Hayakawa; Hiroyuki Mizuguchi
Efficient osteoblast differentiation from mouse bone marrow stromal cells with polylysin-modified adenovirus vectors.
Biochemical and biophysical research communications 2009;379(1):127-32.
2008: Satsuki Itoh; Akiko Hachisuka; Nana Kawasaki; Noritaka Hashii; Reiko Teshima; Takao Hayakawa; Toru Kawanishi; Teruhide Yamaguchi
Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry.
Biochemistry 2008;47(38):10132-54.
2008: Fuminori Sakurai; Shin-ichiro Nakamura; Kimiyo Akitomo; Hiroaki Shibata; Keiji Terao; Kenji Kawabata; Takao Hayakawa; Hiroyuki Mizuguchi
Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(4):726-33.
2007: S Murakami; Fuminori Sakurai; Kenji Kawabata; Naoki Okada; T Fujita; A Yamamoto; Takao Hayakawa; Hiroyuki Mizuguchi
Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells.
Gene therapy 2007;14(21):1525-33.
2007: Kenji Kawabata; Katsuhisa Tashiro; Fuminori Sakurai; Naoki Osada; Jun Kusuda; Takao Hayakawa; Koichi Yamanishi; Hiroyuki Mizuguchi
Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP.
Gene therapy 2007;14(16):1199-207.
2007: Fuminori Sakurai; K Akitomo; Kenji Kawabata; Takao Hayakawa; Hiroyuki Mizuguchi
Downregulation of human CD46 by adenovirus serotype 35 vectors.
Gene therapy 2007;14(11):912-9.
2007: Toshie Kanayasu-Toyoda; Takayoshi Suzuki; Tadashi Oshizawa; Eriko Uchida; Takao Hayakawa; Teruhide Yamaguchi
Granulocyte colony-stimulating factor promotes the translocation of protein kinase Ciota in neutrophilic differentiation cells.
Journal of cellular physiology 2007;211(1):189-96.
2007: Hiroshi Kawai; Takuo Suzuki; Tetsu Kobayashi; Akiko Ishii-Watabe; Haruna Sakurai; Hisayuki Ohata; Kazuo Honda; Kazutaka Momose; Takao Hayakawa; Toru Kawanishi
Caspase cascade proceeds rapidly after cytochrome c release from mitochondria in tumor necrosis factor-alpha-induced cell death.
Journal of pharmacological sciences 2007;103(2):159-67.
2007: Naoya Koizumi; Tomoko Yamaguchi; Kenji Kawabata; Fuminori Sakurai; Tomomi Sasaki; Yoshiteru Watanabe; Takao Hayakawa; Hiroyuki Mizuguchi
Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1767-73.
2007: Shinnosuke Kurachi; Naoya Koizumi; Fuminori Sakurai; Kenji Kawabata; Haruna Sakurai; Shinsaku Nakagawa; Takao Hayakawa; Hiroyuki Mizuguchi
Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon.
Gene therapy 2007;14(3):266-74.
2006: Fuminori Sakurai; Sayaka Murakami; Kenji Kawabata; Naoki Okada; Akira Yamamoto; Tsukasa Seya; Takao Hayakawa; Hiroyuki Mizuguchi
The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.
Journal of controlled release : official journal of the Controlled Release Society 2006;113(3):271-8.
2006: Mizuho Harashima; Shingo Niimi; Hitomi Koyanagi; Masashi Hyuga; Seiji Noma; Taiichiro Seki; Toyohiko Ariga; Toru Kawanishi; Takao Hayakawa
Change in annexin A3 expression by regulatory factors of hepatocyte growth in primary cultured rat hepatocytes.
Biological & pharmaceutical bulletin 2006;29(7):1339-43.
2006: Fuminori Sakurai; Kenji Kawabata; Naoya Koizumi; N Inoue; M Okabe; Teruhide Yamaguchi; Takao Hayakawa; Hiroyuki Mizuguchi
Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice.
Gene therapy 2006;13(14):1118-26.
2006: Kenji Kawabata; Fuminori Sakurai; Naoya Koizumi; Takao Hayakawa; Hiroyuki Mizuguchi
Adenovirus vector-mediated gene transfer into stem cells.
Molecular pharmaceutics 2006;3(2):95-103.
2006: Shinya Kida; Mitsuko Maeda; Keiko Hojo; Yusuke Eto; Jian-Qing Gao; Shinnosuke Kurachi; Hiroyuki Mizuguchi; Takao Hayakawa; Tadanori Mayumi; Shinsaku Nakagawa; Koichi Kawasaki
Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells.
Bioorganic & medicinal chemistry letters 2006;16(3):743-5.
2006: Satsuki Itoh; Nana Kawasaki; Noritaka Hashii; Akira Harazono; Yukari Matsuishi; Takao Hayakawa; Toru Kawanishi
N-linked oligosaccharide analysis of rat brain Thy-1 by liquid chromatography with graphitized carbon column/ion trap-Fourier transform ion cyclotron resonance mass spectrometry in positive and negative ion modes.
Journal of chromatography. A 2006;1103(2):296-306.
2006: Akira Harazono; Nana Kawasaki; Satsuki Itoh; Noritaka Hashii; Akiko Ishii-Watabe; Toru Kawanishi; Takao Hayakawa
Site-specific N-glycosylation analysis of human plasma ceruloplasmin using liquid chromatography with electrospray ionization tandem mass spectrometry.
Analytical biochemistry 2006;348(2):259-68.
2005: Hiroyuki Mizuguchi; Zhi-Li Xu; Fuminori Sakurai; Kenji Kawabata; Teruhide Yamaguchi; Takao Hayakawa
Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):202-11.
2005: Noritaka Hashii; Nana Kawasaki; Satsuki Itoh; Masashi Hyuga; Toru Kawanishi; Takao Hayakawa
Glycomic/glycoproteomic analysis by liquid chromatography/mass spectrometry: analysis of glycan structural alteration in cells.
Proteomics 2005;5(18):4665-72.
2005: Satsuki Itoh; Nana Kawasaki; Akira Harazono; Noritaka Hashii; Yukari Matsuishi; Toru Kawanishi; Takao Hayakawa
Characterization of a gel-separated unknown glycoprotein by liquid chromatography/multistage tandem mass spectrometry: analysis of rat brain Thy-1 separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Journal of chromatography. A 2005;1094(1-2):105-17.
2005: Fuminori Sakurai; Kenji Kawabata; Teruhide Yamaguchi; Takao Hayakawa; Hiroyuki Mizuguchi
Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities.
Gene therapy 2005;12(19):1424-33.
2005: Kenji Kawabata; Fuminori Sakurai; Teruhide Yamaguchi; Takao Hayakawa; Hiroyuki Mizuguchi
Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):547-54.
2005: Hiroyuki Mizuguchi; Tomomi Sasaki; Kenji Kawabata; Fuminori Sakurai; Takao Hayakawa
Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cells.
Biochemical and biophysical research communications 2005;332(4):1101-6.
2005: Yuka Okada; Naoki Okada; Hiroyuki Mizuguchi; Takao Hayakawa; Shinsaku Nakagawa; Tadanori Mayumi
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma.
Cancer gene therapy 2005;12(7):608-16.
2005: Jian-Qing Gao; Toshiki Sugita; Naoko Kanagawa; Keisuke Iida; Naoki Okada; Hiroyuki Mizuguchi; Takashi Nakayama; Takao Hayakawa; Osamu Yoshie; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa
Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector.
Biological & pharmaceutical bulletin 2005;28(6):1066-70.
2005: Shingo Niimi; Mizuho Harashima; Kazuko Takayama; Mayumi Hara; Masashi Hyuga; Taiichiro Seki; Toyohiko Ariga; Toru Kawanishi; Takao Hayakawa
Thrombomodulin enhances the invasive activity of mouse mammary tumor cells.
Journal of biochemistry 2005;137(5):579-86.
2005: Akira Harazono; Nana Kawasaki; Toru Kawanishi; Takao Hayakawa
Site-specific glycosylation analysis of human apolipoprotein B100 using LC/ESI MS/MS.
Glycobiology 2005;15(5):447-62.
2005: Yusuke Eto; Jian-Qing Gao; Fumiko Sekiguchi; Shinnosuke Kurachi; Kazufumi Katayama; Mitsuko Maeda; Koichi Kawasaki; Hiroyuki Mizuguchi; Takao Hayakawa; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa
PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability.
The journal of gene medicine 2005;7(5):604-12.
2005: Zhi-Li Xu; Hiroyuki Mizuguchi; Fuminori Sakurai; Naoya Koizumi; Tetsuji Hosono; Kenji Kawabata; Yoshiteru Watanabe; Teruhide Yamaguchi; Takao Hayakawa
Approaches to improving the kinetics of adenovirus-delivered genes and gene products.
Advanced drug delivery reviews 2005;57(5):781-802.
2005: Tetsuji Hosono; Hiroyuki Mizuguchi; Kazufumi Katayama; Naoya Koizumi; Kenji Kawabata; Teruhide Yamaguchi; Shinsaku Nakagawa; Yoshiteru Watanabe; Tadanori Mayumi; Takao Hayakawa
RNA interference of PPARgamma using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells.
Gene 2005;348():157-65.
2005: Jian-Qing Gao; Toshiki Sugita; Naoko Kanagawa; Keisuke Iida; Yusuke Eto; Yoshiaki Motomura; Hiroyuki Mizuguchi; Yasuo Tsutsumi; Takao Hayakawa; Tadanori Mayumi; Shinsaku Nakagawa
A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma.
Biochemical and biophysical research communications 2005;328(4):1043-50.
2005: Jin Yuan; Noritaka Hashii; Nana Kawasaki; Satsuki Itoh; Toru Kawanishi; Takao Hayakawa
Isotope tag method for quantitative analysis of carbohydrates by liquid chromatography-mass spectrometry.
Journal of chromatography. A 2005;1067(1-2):145-52.
2005: Hiroshi Kawai; Takuo Suzuki; Tetsu Kobayashi; Haruna Sakurai; Hisayuki Ohata; Kazuo Honda; Kazutaka Momose; Iyuki Namekata; Hikaru Tanaka; Koki Shigenobu; Ryu Nakamura; Takao Hayakawa; Toru Kawanishi
Simultaneous real-time detection of initiator- and effector-caspase activation by double fluorescence resonance energy transfer analysis.
Journal of pharmacological sciences 2005;97(3):361-8.
2005: Shingo Niimi; Mizuho Harashima; Masaru Gamou; Masashi Hyuga; Taiichiro Seki; Toyohiko Ariga; Toru Kawanishi; Takao Hayakawa
Expression of annexin A3 in primary cultured parenchymal rat hepatocytes and inhibition of DNA synthesis by suppression of annexin A3 expression using RNA interference.
Biological & pharmaceutical bulletin 2005;28(3):424-8.
2005: Mitsuko Maeda; Shinya Kida; Keiko Hojo; Yusuke Eto; Jian-Qing Gaob; Shinnosuke Kurachi; Fumiko Sekiguchi; Hiroyuki Mizuguchi; Takao Hayakawa; Tadanori Mayumi; Shinsaku Nakagawa; Koichi Kawasaki
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells.
Bioorganic & medicinal chemistry letters 2005;15(3):621-4.
2005: Noritaka Hashii; Nana Kawasaki; Satsuki Itoh; Akira Harazono; Yukari Matsuishi; Takao Hayakawa; Toru Kawanishi
Specific detection of Lewis x-carbohydrates in biological samples using liquid chromatography/multiple-stage tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(22):3315-21.
2005: Jin Yuan; Nana Kawasaki; Noritaka Hashii; Satsuki Itoh; Toru Kawanishi; Takao Hayakawa
Monosaccharide composition analysis of glycoproteins by isotope-tag method and capillary LC/ESI-MS.
Yao xue xue bao = Acta pharmaceutica Sinica 2005;40(1):43-8.
2005: Kayoko Takagi; Reiko Teshima; Haruyo Okunuki; Satsuki Itoh; Nana Kawasaki; Toru Kawanishi; Takao Hayakawa; Yoichi Kohno; Atsuo Urisu; Jun-ichi Sawada
Kinetic analysis of pepsin digestion of chicken egg white ovomucoid and allergenic potential of pepsin fragments.
International archives of allergy and immunology 2005;136(1):23-32.
2004: Hiroko Shibata; Yasuo Yoshioka; Shinji Ikemizu; Kyoko Kobayashi; Yoko Yamamoto; Yohei Mukai; Takayuki Okamoto; Madoka Taniai; Maki Kawamura; Yasuhiro Abe; Shinsaku Nakagawa; Takao Hayakawa; Satoshi Nagata; Yuriko Yamagata; Tadanori Mayumi; Haruhiko Kamada; Yasuo Tsutsumi
Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8293-300.
2004: Shingo Niimi; Masashi Hyuga; Mizuho Harashima; Taiichiro Seki; Toyohiko Ariga; Toru Kawanishi; Takao Hayakawa
Isolated small rat hepatocytes express both annexin III and terminal differentiated hepatocyte markers, tyrosine aminotransferase and tryptophan oxygenase, at the mRNA level.
Biological & pharmaceutical bulletin 2004;27(11):1864-6.
2004: Takayuki Okamoto; Yohei Mukai; Yasuo Yoshioka; Hiroko Shibata; Maki Kawamura; Yoko Yamamoto; Shinsaku Nakagawa; Haruhiko Kamada; Takao Hayakawa; Tadanori Mayumi; Yasuo Tsutsumi
Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen.
Biochemical and biophysical research communications 2004;323(2):583-91.
2004: Eriko Uchida; Koei Sato; Akiko Iwata; Akiko Ishii-Watabe; Hiroyuki Mizuguchi; Mikio Hikata; Mitsuhiro Murata; Teruhide Yamaguchi; Takao Hayakawa
An improved method for detection of replication-competent retrovirus in retrovirus vector products.
Biologicals : journal of the International Association of Biological Standardization 2004;32(3):139-46.
2004: Hiroshi Kawai; Takuo Suzuki; Tetsu Kobayashi; Hiroyuki Mizuguchi; Takao Hayakawa; Toru Kawanishi
Simultaneous imaging of initiator/effector caspase activity and mitochondrial membrane potential during cell death in living HeLa cells.
Biochimica et biophysica acta 2004;1693(2):101-10.
2004: Tetsuji Hosono; Hiroyuki Mizuguchi; Kazufumi Katayama; Zhi-Li Xu; Fuminori Sakurai; Akiko Ishii-Watabe; Kenji Kawabata; Teruhide Yamaguchi; Shinsaku Nakagawa; Tadanori Mayumi; Takao Hayakawa
Adenovirus vector-mediated doxycycline-inducible RNA interference.
Human gene therapy 2004;15(8):813-9.
2004: Jian-Qing Gao; S Inoue; Y Tsukada; Kazufumi Katayama; Yusuke Eto; Shinnosuke Kurachi; Hiroyuki Mizuguchi; Takao Hayakawa; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber.
Die Pharmazie 2004;59(7):571-2.
2004: Masashi Hyuga; Satsuki Itoh; Nana Kawasaki; Miyako Ohta; Akiko Ishii; Sumiko Hyuga; Takao Hayakawa
Analysis of site-specific glycosylation in recombinant human follistatin expressed in Chinese hamster ovary cells.
Biologicals : journal of the International Association of Biological Standardization 2004;32(2):70-7.
2004: Yusuke Eto; Jian-Qing Gao; Fumiko Sekiguchi; Shinnosuke Kurachi; Kazufumi Katayama; Hiroyuki Mizuguchi; Takao Hayakawa; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa
Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA).
Biological & pharmaceutical bulletin 2004;27(6):936-8.
2004: Masashi Hyuga; Sumiko Hyuga; Nana Kawasaki; Miyako Ohta; Satsuki Itoh; Shingo Niimi; Toru Kawanishi; Takao Hayakawa
Enhancement of hepatocyte growth factor-induced cell scattering in N-acetylglucosaminyltransferase III-transfected HepG2 cells.
Biological & pharmaceutical bulletin 2004;27(6):781-5.
2004: Jian-Qing Gao; L S Alexandre; Yasuhiro Tsuda; Kazufumi Katayama; Yusuke Eto; Fumiko Sekiguchi; Hiroyuki Mizuguchi; Takao Hayakawa; Takashi Nakayama; Osamu Yoshie; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa
Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors.
Die Pharmazie 2004;59(3):238-9.
2004: Kazufumi Katayama; Koichiro Wada; Hiroyuki Miyoshi; Kozo Ohashi; Masashi Tachibana; Rie Furuki; Hiroyuki Mizuguchi; Takao Hayakawa; Atsushi Nakajima; Takashi Kadowaki; Yasuo Tsutsumi; Shinsaku Nakagawa; Yoshinori Kamisaki; Tadanori Mayumi
RNA interfering approach for clarifying the PPARgamma pathway using lentiviral vector expressing short hairpin RNA.
FEBS letters 2004;560(1-3):178-82.
2004: Jun Okabe; Akiko Eguchi; Renu Wadhwa; Randeep Rakwal; Rumi Tsukinoki; Takao Hayakawa; Mahito Nakanishi
Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts.
Human molecular genetics 2004;13(3):285-93.
2004: Tetsu Kobayashi; Hiroshi Kawai; Takuo Suzuki; Toru Kawanishi; Takao Hayakawa
Improved sensitivity for insulin in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry by premixing alpha-cyano-4-hydroxycinnamic acid matrix with transferrin.
Rapid communications in mass spectrometry : RCM 2004;18(10):1156-60.
2004: Nana Kawasaki; Miyako Ohta; Satsuki Itoh; Takao Hayakawa
Analyses of glycopeptides and glycoproteins by liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2004;251():263-74.
2003: Tadashi Oshizawa; Teruhide Yamaguchi; Kazuhiro Suzuki; Yukio Yamamoto; Takao Hayakawa
Possible involvement of optimally phosphorylated L-plastin in activation of superoxide-generating NADPH oxidase.
Journal of biochemistry 2003;134(6):827-34.
2003: Akiko Ishii-Watabe; Eriko Uchida; Akiko Iwata; Ryuji Nagata; Kouei Satoh; Kejun Fan; Mitsuhiro Murata; Hiroyuki Mizuguchi; Nana Kawasaki; Toru Kawanishi; Teruhide Yamaguchi; Takao Hayakawa
Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(6):1009-16.
2003: Naoya Koizumi; Hiroyuki Mizuguchi; Fuminori Sakurai; Teruhide Yamaguchi; Yoshiteru Watanabe; Takao Hayakawa
Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.
Journal of virology 2003;77(24):13062-72.
2003: Koei Satoh; Akiko Iwata; Mitsuhiro Murata; Mikio Hikata; Takao Hayakawa; Teruhide Yamaguchi
Virus concentration using polyethyleneimine-conjugated magnetic beads for improving the sensitivity of nucleic acid amplification tests.
Journal of virological methods 2003;114(1):11-9.
2003: Fuminori Sakurai; Hiroyuki Mizuguchi; Teruhide Yamaguchi; Takao Hayakawa
Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(5):813-21.
2003: Hiroyuki Mizuguchi; Zhi-Li Xu; Fuminori Sakurai; Tadanori Mayumi; Takao Hayakawa
Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions.
Human gene therapy 2003;14(13):1265-77.
2003: Akiko Iwata; Koei Satoh; Mitsuhiro Murata; Mikio Hikata; Takao Hayakawa; Teruhide Yamaguchi
Virus concentration using sulfonated magnetic beads to improve sensitivity in nucleic acid amplification tests.
Biological & pharmaceutical bulletin 2003;26(8):1065-9.
2003: Jian-Qing Gao; Yasuhiro Tsuda; Kazufumi Katayama; Takashi Nakayama; Yutaka Hatanaka; Yoichi Tani; Hiroyuki Mizuguchi; Takao Hayakawa; Osamu Yoshie; Yasuo Tsutsumi; Tadanori Mayumi; Shinsaku Nakagawa
Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector.
Cancer research 2003;63(15):4420-5.
2003: Toshie Kanayasu-Toyoda; Teruhide Yamaguchi; Tadashi Oshizawa; Eriko Uchida; Takao Hayakawa
The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells.
Biochemical pharmacology 2003;66(1):133-40.
2003: Zhi-Li Xu; Hiroyuki Mizuguchi; Tadanori Mayumi; Takao Hayakawa
Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors.
Biochimica et biophysica acta 2003;1621(3):266-71.
2003: Fuminori Sakurai; Hiroyuki Mizuguchi; Takao Hayakawa
Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector.
Gene therapy 2003;10(12):1041-8.
2003: Zhi-Li Xu; Hiroyuki Mizuguchi; Tadanori Mayumi; Takao Hayakawa
Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems.
Gene 2003;309(2):145-51.
2003: Kazufumi Katayama; Koichiro Wada; Atsushi Nakajima; Hiroyuki Mizuguchi; Takao Hayakawa; Shinsaku Nakagawa; Takashi Kadowaki; Ryozo Nagai; Yoshinori Kamisaki; Richard S Blumberg; Tadanori Mayumi
A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model.
Gastroenterology 2003;124(5):1315-24.
2003: Nana Kawasaki; Satsuki Itoh; Miyako Ohta; Takao Hayakawa
Microanalysis of N-linked oligosaccharides in a glycoprotein by capillary liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry.
Analytical biochemistry 2003;316(1):15-22.
2003: Naoya Koizumi; Hiroyuki Mizuguchi; Naoki Utoguchi; Yoshiteru Watanabe; Takao Hayakawa
Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob.
The journal of gene medicine 2003;5(4):267-76.
2003: Toshie Kanayasu-Toyoda; Teruhide Yamaguchi; Tadashi Oshizawa; Takao Hayakawa
CD31 (PECAM-1)-bright cells derived from AC133-positive cells in human peripheral blood as endothelial-precursor cells.
Journal of cellular physiology 2003;195(1):119-29.
2003: Tetsu Kobayashi; Shingo Niimi; Toru Kawanishi; Masamichi Fukuoka; Takao Hayakawa
Changes in peroxisome proliferator-activated receptor gamma-regulated gene expression and inhibin/activin-follistatin system gene expression in rat testis after an administration of di-n-butyl phthalate.
Toxicology letters 2003;138(3):215-25.
2003: Risako Nakano; Tetsuhiko Nakagawa; Susumu Imazu; Kazufumi Katayama; Hiroyuki Mizuguchi; Takao Hayakawa; Yasuo Tsutsumi; Shinsaku Nakagawa; Tadanori Mayumi
A novel T7 system utilizing mRNA coding for T7 RNA polymerase.
Biochemical and biophysical research communications 2003;301(4):974-8.
2003: Shingo Niimi; Tadashi Oshizawa; Teruhide Yamaguchi; Mizuho Harashima; Taiichiro Seki; Toyohiko Ariga; Toru Kawanishi; Takao Hayakawa
Specific expression of annexin III in rat-small-hepatocytes.
Biochemical and biophysical research communications 2003;300(3):770-4.
2002: Satsuki Itoh; Nana Kawasaki; Miyako Ohta; Takao Hayakawa
Structural analysis of a glycoprotein by liquid chromatography-mass spectrometry and liquid chromatography with tandem mass spectrometry. Application to recombinant human thrombomodulin.
Journal of chromatography. A 2002;978(1-2):141-52.
2002: Shingo Niimi; Masashi Hyuga; Hiromi Kazama; Masami Inagawa; Taiichiro Seki; Toyohiko Ariga; Tetsu Kobayashi; Takao Hayakawa
Activins A, AB, and B inhibit hepatocyte growth factor synthesis by MRC-5 human lung fibroblasts.
Biological & pharmaceutical bulletin 2002;25(11):1405-8.
2002: Teruo Akuta; Akiko Eguchi; Hajime Okuyama; Takao Senda; Hachiro Inokuchi; Yosuke Suzuki; Emi Nagoshi; Hiroyuki Mizuguchi; Takao Hayakawa; Katsuo Takeda; Mamoru Hasegawa; Mahito Nakanishi
Enhancement of phage-mediated gene transfer by nuclear localization signal.
Biochemical and biophysical research communications 2002;297(4):779-86.
2002: Tetsu Kobayashi; Shingo Niimi; Masamichi Fukuoka; Takao Hayakawa
Regulation of inhibin beta chains and follistatin mRNA levels during rat hepatocyte growth induced by the peroxisome proliferator di-n-butyl phthalate.
Biological & pharmaceutical bulletin 2002;25(9):1214-6.
2002: Miyako Ohta; Nana Kawasaki; Satsuki Itoh; Takao Hayakawa
Usefulness of glycopeptide mapping by liquid chromatography/mass spectrometry in comparability assessment of glycoprotein products.
Biologicals : journal of the International Association of Biological Standardization 2002;30(3):235-44.
2002: Toshie Kanayasu-Toyoda; Teruhide Yamaguchi; Tadashi Oshizawa; Mieko Kogi; Eriko Uchida; Takao Hayakawa
Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells.
Archives of biochemistry and biophysics 2002;405(1):21-31.
2002: Satsuki Itoh; Nana Kawasaki; Miyako Ohta; Masashi Hyuga; Sumiko Hyuga; Takao Hayakawa
Simultaneous microanalysis of N-linked oligosaccharides in a glycoprotein using microbore graphitized carbon column liquid chromatography-mass spectrometry.
Journal of chromatography. A 2002;968(1-2):89-100.
2002: Eriko Uchida; Hiroyuki Mizuguchi; Akiko Ishii-Watabe; Takao Hayakawa
Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells.
Biological & pharmaceutical bulletin 2002;25(7):891-7.
2002: Nana Kawasaki; Miyako Ohta; Satsuki Itoh; Masashi Hyuga; Sumiko Hyuga; Takao Hayakawa
Usefulness of sugar mapping by liquid chromatography/mass spectrometry in comparability assessments of glycoprotein products.
Biologicals : journal of the International Association of Biological Standardization 2002;30(2):113-23.
2002: Hiroyuki Mizuguchi; Naoya Koizumi; Tetsuji Hosono; Akiko Ishii-Watabe; Eriko Uchida; Naoki Utoguchi; Yoshiteru Watanabe; Takao Hayakawa
CAR- or alphav integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice.
Gene therapy 2002;9(12):769-76.
2002: Zhi-Li Xu; Hiroyuki Mizuguchi; Akiko Ishii-Watabe; Eriko Uchida; Tadanori Mayumi; Takao Hayakawa
Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):155-63.
2002: Hiroyuki Mizuguchi; Takao Hayakawa
The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector.
The journal of gene medicine 2002;4(3):240-7.
2002: Shingo Niimi; Mai Horikawa; Taiichiro Seki; Toyohiko Ariga; Tetsu Kobayashi; Takao Hayakawa
Effect of activins AB and B on DNA synthesis stimulated by epidermal growth factor in primary cultured rat hepatocytes.
Biological & pharmaceutical bulletin 2002;25(4):437-40.
2002: Hiroyuki Mizuguchi; Takao Hayakawa
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.
Cancer gene therapy 2002;9(3):236-42.
2002: Shingo Niimi; Tadashi Oshizawa; Masaaki Naotsuka; Sumiaki Ohba; Akira Yokozawa; Tomoyo Murata; Takao Hayakawa
Establishment of a standard assay method for human thrombomodulin and determination of the activity of the Japanese reference standard.
Biologicals : journal of the International Association of Biological Standardization 2002;30(1):69-76.
2002: Hiroyuki Mizuguchi; Takao Hayakawa
Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes.
Gene 2002;285(1-2):69-77.
2001: Nana Kawasaki; Yuji Haishima; Miyako Ohta; Satsuki Itoh; Masashi Hyuga; Sumiko Hyuga; Takao Hayakawa
Structural analysis of sulfated N-linked oligosaccharides in erythropoietin.
Glycobiology 2001;11(12):1043-9.
2001: Hiroyuki Mizuguchi; M A Kay; Takao Hayakawa
Approaches for generating recombinant adenovirus vectors.
Advanced drug delivery reviews 2001;52(3):165-76.
2001: Hiroyuki Mizuguchi; Takao Hayakawa
Characteristics of adenovirus-mediated tetracycline-controllable expression system.
Biochimica et biophysica acta 2001;1568(1):21-9.
2001: Naoya Koizumi; Hiroyuki Mizuguchi; Tetsuji Hosono; Akiko Ishii-Watabe; Eriko Uchida; Naoki Utoguchi; Yoshiteru Watanabe; Takao Hayakawa
Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide.
Biochimica et biophysica acta 2001;1568(1):13-20.
2001: Sumiko Hyuga; Nana Kawasaki; Masashi Hyuga; Miyako Ohta; R Shibayama; Toru Kawanishi; S Yamagata; T Yamagata; Takao Hayakawa
Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met.
International journal of cancer. Journal international du cancer 2001;94(3):328-34.
2001: T Kawanishi; T Kiuchi; H Asoh; R Shibayama; H Kawai; H Ohata; K Momose; Takao Hayakawa
Effect of tributyltin chloride on the release of calcium ion from intracellular calcium stores in rat hepatocytes.
Biochemical pharmacology 2001;62(7):863-72.
2001: Akiko Ishii-Watabe; Eriko Uchida; Hiroyuki Mizuguchi; Takao Hayakawa
Involvement of a calcium-independent pathway in plasmin-induced platelet shape change.
Life sciences 2001;69(8):945-60.
2001: Akiko Eguchi; Teruo Akuta; H Okuyama; Takao Senda; H Yokoi; Hachiro Inokuchi; Shinobu C Fujita; Takao Hayakawa; Kiyoshi Takeda; Mamoru Hasegawa; Mahito Nakanishi
Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells.
The Journal of biological chemistry 2001;276(28):26204-10.
2001: Zhi-Li Xu; Hiroyuki Mizuguchi; Akiko Ishii-Watabe; Eriko Uchida; Tadanori Mayumi; Takao Hayakawa
Optimization of transcriptional regulatory elements for constructing plasmid vectors.
Gene 2001;272(1-2):149-56.
2001: Hiroyuki Mizuguchi; Naoya Koizumi; Tetsuji Hosono; Naoki Utoguchi; Yoshiteru Watanabe; M A Kay; Takao Hayakawa
A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob.
Gene therapy 2001;8(9):730-5.
2001: Hiroyuki Mizuguchi; M A Kay; Takao Hayakawa
In vitro ligation-based cloning of foreign DNAs into the E3 and E1 deletion regions for generation of recombinant adenovirus vectors.
BioTechniques 2001;30(5):1112-4, 1116.
2001: Miyako Ohta; Nana Kawasaki; Sumiko Hyuga; Masashi Hyuga; Takao Hayakawa
Selective glycopeptide mapping of erythropoietin by on-line high-performance liquid chromatography--electrospray ionization mass spectrometry.
Journal of chromatography. A 2001;910(1):1-11.
2001: Satsuki Itoh; Nana Kawasaki; Miyako Ohta; Masashi Hyuga; Sumiko Hyuga; Takao Hayakawa
[Study on evaluating methods for the quality control of glycoprotein products. (III)--Erythropoietin products. Part 3].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2001;(119):65-9.
2001: Masashi Hyuga; Nana Kawasaki; Sumiko Hyuga; Miyako Ohta; Satsuki Itoh; Takao Hayakawa
[Rapid quantitation of follistatin by surface plasmon resonance (SPR) immunoassay].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2001;(119):57-60.
2001: Sachiko Matsui; Reiko Adachi; Kaoru Kusui; Teruhide Yamaguchi; Tadashi Kasahara; Takao Hayakawa; Kazuhiro Suzuki
U73122 inhibits the dephosphorylation and translocation of cofilin in activated macrophage-like U937 cells.
Cellular signalling 2001;13(1):17-22.
2000: Jun Okabe; Akiko Eguchi; A Masago; Takao Hayakawa; Mahito Nakanishi
TRF1 is a critical trans-acting factor required for de novo telomere formation in human cells.
Human molecular genetics 2000;9(18):2639-50.
2000: Nana Kawasaki; Miyako Ohta; Sumiko Hyuga; Masashi Hyuga; Takao Hayakawa
Application of liquid chromatography/mass spectrometry and liquid chromatography with tandem mass spectrometry to the analysis of the site-specific carbohydrate heterogeneity in erythropoietin.
Analytical biochemistry 2000;285(1):82-91.
2000: Osamu Hashimoto; Nana Kawasaki; Kunihiro Tsuchida; Shunichi Shimasaki; Takao Hayakawa; Hiromu Sugino
Difference between follistatin isoforms in the inhibition of activin signalling: activin neutralizing activity of follistatin isoforms is dependent on their affinity for activin.
Cellular signalling 2000;12(8):565-71.
2000: Akiko Eguchi; T Kondoh; H Kosaka; Toshihiko Suzuki; H Momota; A Masago; Takuya Yoshida; H Taira; A Ishii-Watabe; Jun Okabe; J Hu; N Miura; Shigeru Ueda; Yasuhiko Suzuki; T Taki; Takao Hayakawa; Mahito Nakanishi
Identification and characterization of cell lines with a defect in a post-adsorption stage of Sendai virus-mediated membrane fusion.
The Journal of biological chemistry 2000;275(23):17549-55.
2000: Tetsu Kobayashi; Shingo Niimi; Osamu Hashimoto; Takao Hayakawa
Expression of inhibin betaA, betaB and follistatin mRNAs in the carbon tetrachloride induced rat liver regeneration model.
Biological & pharmaceutical bulletin 2000;23(6):755-7.
2000: Akiko Ishii-Watabe; Eriko Uchida; Hiroyuki Mizuguchi; Takao Hayakawa
On the mechanism of plasmin-induced platelet aggregation. Implications of the dual role of granule ADP.
Biochemical pharmacology 2000;59(11):1345-55.
2000: Sumiko Hyuga; Nana Kawasaki; Osamu Hashimoto; Masashi Hyuga; Miyako Ohta; S Yamagata; T Yamagata; Takao Hayakawa
Possible role of hepatocyte growth factor/scatter factor and activin A produced by the target organ in liver metastasis.
Cancer letters 2000;153(1-2):137-43.
2000: Hiroyuki Mizuguchi; T Hosono; Takao Hayakawa
Long-term replication of Epstein-Barr virus-derived episomal vectors in the rodent cells.
FEBS letters 2000;472(2-3):173-8.
2000: Hiroyuki Mizuguchi; Z Xu; Akiko Ishii-Watabe; Eriko Uchida; Takao Hayakawa
IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(4):376-82.
2000: Eiji Kohmura; Takamichi Yuguchi; T Sakaki; M Nonaka; Toshiyuki Fujinaka; Takao Hayakawa; Toshiki Yoshimine
Changes in tissue-plasminogen activator mRNA expression following cortical ablation in the rat brain.
Journal of molecular neuroscience : MN 2000;14(1-2):53-9.
1999: Eiji Kohmura; Takamichi Yuguchi; Toshiki Yoshimine; Toshiyuki Fujinaka; N Koseki; A Sano; Akiyoshi Kishino; Chikao Nakayama; T Sakaki; M Nonaka; O Takemoto; Takao Hayakawa
BDNF atelocollagen mini-pellet accelerates facial nerve regeneration.
Brain research 1999;849(1-2):235-8.
1999: M Nonaka; Toshiki Yoshimine; Eiji Kumura; Eiji Kohmura; Akatsuki Wakayama; Takao Hayakawa
Decrease in N-acetylaspartate without commensurate accumulation of acetate in focal cerebral ischemia in rat.
Neurological research 1999;21(8):771-4.
1999: Toshie Kanayasu-Toyoda; Teruhide Yamaguchi; Eriko Uchida; Takao Hayakawa
Commitment of neutrophilic differentiation and proliferation of HL-60 cells coincides with expression of transferrin receptor. Effect of granulocyte colony stimulating factor on differentiation and proliferation.
The Journal of biological chemistry 1999;274(36):25471-80.
1999: Masaaki Taniguchi; H Takimoto; Toshiki Yoshimine; N Shimada; Y Miyao; Masayuki Hirata; Motohiko Maruno; Amami Kato; Eiji Kohmura; Takao Hayakawa
Application of a rigid endoscope to the microsurgical management of 54 cerebral aneurysms: results in 48 patients.
Journal of neurosurgery 1999;91(2):231-7.
1999: M Nonaka; Eiji Kohmura; Toshihide Yamashita; A Yamauchi; Toshiyuki Fujinaka; Toshiki Yoshimine; Masaya Tohyama; Takao Hayakawa
Kainic acid-induced seizure upregulates Na(+)/myo-inositol cotransporter mRNA in rat brain.
Brain research. Molecular brain research 1999;70(2):179-86.
1999: Yoshihisa Hagihara; Youichi Saitoh; N Arita; Yutaka Eguchi; Y Tsujimoto; Toshiki Yoshimine; Takao Hayakawa
Long-term functional assessment of encapsulated cells transfected with Tet-On system.
Cell transplantation 1999;8(4):431-4.
1999: Nana Kawasaki; Y C Lee; Osamu Hashimoto; M Yamamoto; Toru Kawanishi; Takao Hayakawa
Fluorometric determination of aminopolycarboxylates using Fluo-3.
Analytical biochemistry 1999;270(2):329-31.
1999: Teruhide Yamaguchi; T Mukasa; Eriko Uchida; Toshie Kanayasu-Toyoda; Takao Hayakawa
The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3.
The Journal of biological chemistry 1999;274(22):15575-81.
1999: Nana Kawasaki; Miyako Ohta; Sumiko Hyuga; Osamu Hashimoto; Takao Hayakawa
Analysis of carbohydrate heterogeneity in a glycoprotein using liquid chromatography/mass spectrometry and liquid chromatography with tandem mass spectrometry.
Analytical biochemistry 1999;269(2):297-303.
1999: K Nagaishi; Reiko Adachi; Toru Kawanishi; Teruhide Yamaguchi; Tadashi Kasahara; Takao Hayakawa; Kazuhiro Suzuki
Participation of cofilin in opsonized zymosan-triggered activation of neutrophil-like HL-60 cells through rapid dephosphorylation and translocation to plasma membranes.
Journal of biochemistry 1999;125(5):891-8.
1999: T Kawanishi; H Asoh; T Kato; C Uneyama; K Toyoda; R Teshima; H Ikebuchi; H Ohata; K Momose; Takao Hayakawa; M Takahashi
Suppression of calcium oscillation by tri-n-butyltin chloride in cultured rat hepatocytes.
Toxicology and applied pharmacology 1999;155(1):54-61.
1999: K Hara; S Nakatani; K Ozaki; Takao Hayakawa
Evaluation of the pressure transfer system in the intracranial cavity by coherency.
Neurologia medico-chirurgica 1999;39(2):127-32; discussion 132-3.
1999: A Watabe; T Yamaguchi; Toru Kawanishi; Eriko Uchida; Akiko Eguchi; Hiroyuki Mizuguchi; Tadanori Mayumi; Mahito Nakanishi; Takao Hayakawa
Target-cell specificity of fusogenic liposomes: membrane fusion-mediated macromolecule delivery into human blood mononuclear cells.
Biochimica et biophysica acta 1999;1416(1-2):339-48.
1999: Motohiko Maruno; Toshiki Yoshimine; AK Muhammad; Hirotomo Ninomiya; Amami Kato; Takao Hayakawa
Chromosomal aberrations detected by comparative genomic hybridization (CGH) in human astrocytic tumors.
Cancer letters 1999;135(1):61-6.
1999: Mahito Nakanishi; Hiroyuki Mizuguchi; K Ashihara; Takao Senda; Akiko Eguchi; A Watabe; Tsuyoshi Nakanishi; M Kondo; T Nakagawa; A Masago; Jun Okabe; Shigeru Ueda; Tadanori Mayumi; Takao Hayakawa
Gene delivery systems using the Sendai virus.
Molecular membrane biology 1999;16(1):123-7.
1999: K Morimoto; N Maeda; A A Abdel-Alim; S Toyoshima; Takao Hayakawa
Structural characterization of recombinant human erythropoietins by fluorophore-assisted carbohydrate electrophoresis.
Biological & pharmaceutical bulletin 1999;22(1):5-10.
1999: Haruhiko Kishima; Kiyonori Shimizu; K Tamura; Y Miyao; E Mabuchi; E Tominaga; J Matsuzaki; Takao Hayakawa
Monoclonal antibody ONS-M21 recognizes integrin alpha3 in gliomas and medulloblastomas.
British journal of cancer 1999;79(2):333-9.
1998: Hiroyuki Mizuguchi; Tsutomu Nakagawa; Satoru Toyosawa; Mahito Nakanishi; Susumu Imazu; Tsuyoshi Nakanishi; Yasuo Tsutsumi; Shinsaku Nakagawa; Takao Hayakawa; Naokuni Ijuhin; Tadanori Mayumi
Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors.
Cancer research 1998;58(24):5725-30.
1998: S Nakajima; Toshiki Yoshimine; S Wakita; Y Sato; N Hata; M Yamada; M Fujiwara; S Tamura; Amami Kato; Takao Hayakawa
Scalp localization using a simple algorithm.
Neurological research 1998;20(8):751-3.
1998: Amami Kato; Toshiki Yoshimine; Masayuki Hirata; S Nakajima; Motohiko Maruno; Mamoru Taneda; Takao Hayakawa
Mobile fluoroscopic open stereotaxy for MRI-negative angiographic microlesions.
Neurological research 1998;20(8):713-8.
1998: Toshiki Yoshimine; Amami Kato; Y Nii; M Maruno; Takao Hayakawa
[Anatomical and surgical note: functional hemispherectomy].
No shinkei geka. Neurological surgery 1998;26(11):956-68.
1998: S Nimi; Teruhide Yamaguchi; Takao Hayakawa
Effect of dexamethasone pretreatment on the dexamethasone-dependent induction of tyrosine aminotransferase activity in primary cultured rat hepatocytes.
Biological & pharmaceutical bulletin 1998;21(10):1009-12.
1998: Motohiko Maruno; Toshiki Yoshimine; AK Muhammad; Hirotomo Ninomiya; Takao Hayakawa
Chromosomal losses and gains in meningiomas: comparative genomic hybridization (CGH) study of the whole genome.
Neurological research 1998;20(7):612-6.
1998: Toshiki Yoshimine; Amami Kato; Masaaki Taniguchi; Hirotomo Ninomiya; Masayuki Hirata; Y Nii; Motohiko Maruno; Norio Hirabuki; Hideji Nakamura; J K Lee; T S Ko; Takao Hayakawa
Translucence stereoscopy of interictal magnetoencephalographic epileptiform discharge.
Neurological research 1998;20(7):572-6.
1998: KC Park; Kiyonori Shimizu; Takao Hayakawa
Interferon yield and MHC antigen expression of human medulloblastoma cells and its suppression during dibutyryl cyclic AMP-induced differentiation: do medulloblastoma cells derive from bipotent neuronal and glial progenitors?
Cellular and molecular neurobiology 1998;18(5):497-507.
1998: Hirotomo Ninomiya; Toshiki Yoshimine; Motohiko Maruno; Amami Kato; Takao Hayakawa
A peritoneal marker for optimal timing of ventriculo-peritoneal shunt revision in early childhood.
Neurological research 1998;20(6):526-8.
1998: Masayuki Hirata; Amami Kato; Toshiki Yoshimine; S Nakajima; Motohiko Maruno; S Tamura; F Kishino; Takao Hayakawa
Spatial perception in macroscopic and microscopic surgical manipulations: differences between experienced and inexperienced surgeons.
Neurological research 1998;20(6):509-12.
1998: K Yamanaka; Eiji Kumura; Toshiki Yoshimine; Motohiko Maruno; Manabu Taniguchi; H Kosaka; Takao Hayakawa
Cellular expression of inducible nitric oxide synthase following rat cortical incision and its suppression by hydroxyl radical scavenger, 1,2-bis(nicotinamido)propane.
Neuroscience research 1998;31(4):347-50.
1998: Teruhide Yamaguchi; Tadashi Oshizawa; T Yamaguchi; Kazuhiro Suzuki; Yukio Yamamoto; Takao Hayakawa
Granulocyte colony-stimulating factor-induced dephosphorylation of a 45 kD cytosolic protein in HL-60 cells differentiating into neutrophils.
British journal of haematology 1998;102(3):798-803.
1998: T Ohnishi; H Matsumura; Shuichi Izumoto; S Hiraga; Takao Hayakawa
A novel model of glioma cell invasion using organotypic brain slice culture.
Cancer research 1998;58(14):2935-40.
1998: Masaaki Taniguchi; Toshiki Yoshimine; Amami Kato; Motohiko Maruno; Norio Hirabuki; Hideji Nakamura; Katsumi Imai; S Okada; Takao Hayakawa
Dysembryoplastic neuroepithelial tumor in the insular cortex. Three dimensional magnetoencephalographic localization of epileptic discharges.
Neurological research 1998;20(5):433-8.
1998: Koichi Iwatsuki; Eiji Kumura; Toshiki Yoshimine; K Yamamoto; M Sato; Takao Hayakawa
Increase in jugular levels of polymorphonuclear neutrophil elastase in patients with acute cerebral infarction.
Neurological research 1998;20(5):397-402.
1998: Mahito Nakanishi; H Mizuguchia; K Ashihara; Takao Senda; Teruo Akuta; Jun Okabe; Emi Nagoshi; A Masago; Akiko Eguchi; Yasuhiko Suzuki; Hachiro Inokuchi; A Watabe; Shigeru Ueda; Takao Hayakawa; Tadanori Mayumi
Gene transfer vectors based on Sendai virus.
Journal of controlled release : official journal of the Controlled Release Society 1998;54(1):61-8.
1998: KC Park; Kiyonori Shimizu; Takao Hayakawa; N Tanaka
Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor-1 and -2.
British journal of cancer 1998;77(12):2081-7.
1998: Amami Kato; Masayuki Hirata; Toshiki Yoshimine; S Tamura; F Kishino; Takao Hayakawa
[Discrepancy between surgeon's binocular parallax perception and manipulation in the neurosurgical operation].
No shinkei geka. Neurological surgery 1998;26(6):517-22.
1998: Masayuki Hirata; Toshiki Yoshimine; Amami Kato; M Ito; Norio Hirabuki; Masaaki Taniguchi; Hideji Nakamura; Takao Hayakawa
Computational imaging of cerebral perfusion by real time processing of DSA images. Clinical applications.
Neurological research 1998;20(4):327-32.
1998: Kiyonori Shimizu; KC Park; K Tamura; Haruhiko Kishima; H Kawata; Y Yoshimura; Y Sekimori; Y Miyao; Takao Hayakawa
Internalization with high targeting potential of mouse monoclonal antibody ONS-M21 recognizing human malignant glioma antigen.
Cancer letters 1998;127(1-2):171-6.
1998: Masaaki Taniguchi; Toshiki Yoshimine; Douglas Cheyne; Amami Kato; T Kihara; Hirotomo Ninomiya; Masayuki Hirata; Norio Hirabuki; Hideji Nakamura; Takao Hayakawa
Neuromagnetic fields preceding unilateral movements in dextrals and sinistrals.
Neuroreport 1998;9(7):1497-502.
1998: Toshiki Yoshimine; Motohiko Maruno; Eiji Kumura; A K M Ghulam Muhammad; Hirotomo Ninomiya; Amami Kato; Takao Hayakawa
Stochastic determination of the chromosomal region responsible for expression of human glial fibrillary acidic protein in astrocytic tumors.
Neuroscience letters 1998;247(1):29-32.
1998: Youichi Saitoh; Yutaka Eguchi; Yoshihisa Hagihara; N Arita; M Watahiki; Y Tsujimoto; Takao Hayakawa
Dose-dependent doxycycline-mediated adrenocorticotropic hormone secretion from encapsulated Tet-on proopiomelanocortin Neuro2A cells in the subarachnoid space.
Human gene therapy 1998;9(7):997-1002.
1998: Teruhide Yamaguchi; T Yamaguchi; Takao Hayakawa
Granulocyte colony-stimulating factor promotes functional maturation of O-2 generating system during differentiation of HL-60 cells to neutrophil-like cells.
Archives of biochemistry and biophysics 1998;353(1):93-100.
1998: M Nonaka; Toshiki Yoshimine; Eiji Kohmura; Akatsuki Wakayama; T Yamashita; Takao Hayakawa
Changes in brain organic osmolytes in experimental cerebral ischemia.
Journal of the neurological sciences 1998;157(1):25-30.
1998: M Nonaka; Eiji Kohmura; Toshihide Yamashita; Shoichi Shimada; K Tanaka; Toshiki Yoshimine; Masaya Tohyama; Takao Hayakawa
Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure.
Brain research. Molecular brain research 1998;55(1):54-60.
1998: Toshiki Yoshimine; H Tanabe; Motohiko Maruno; Amami Kato; S Hirano; Manabu Taniguchi; Y Nakagawa; Takashi Nishikawa; Masatoshi Takeda; Takao Hayakawa
Aberrant muscle activation in patients after resection of non-primary motor areas: demonstration by surface electromyography.
Neuroscience letters 1998;244(3):153-6.
1998: O Takemoto; Toshiki Yoshimine; AK Muhammad; Motohiko Maruno; S Yamamoto; K Fujioka; N Koseki; Y Takada; A Sano; H Maeda; Takao Hayakawa
Distribution of nerve growth factor in cat brains following topical application of solution or Minipellet.
Neurological research 1998;20(2):116-20.
1998: Haruhiko Kishima; Kiyonori Shimizu; Y Miyao; E Mabuchi; Takao Hayakawa
Possible common origin of alpha-fetoprotein- and human chorionic gonadotropin--secreting cells in intracranial germ cell tumor. Case report.
Journal of neurosurgery 1998;88(3):576-80.
1998: N Kawasaki; K Morimoto; Takao Hayakawa
Control of hemoglobin synthesis in erythroid differentiating K562 cells. II. Studies of iron mobilization in erythroid cells by high-performance liquid chromatography-electrochemical detection.
Journal of chromatography. B, Biomedical sciences and applications 1998;705(2):193-201.
1998: Kiyofumi Yamada; T Kishiguchi; M Ito; H Otsuki; E Kohmura; M Taneda; Takao Hayakawa
Restenosis following carotid endarterectomy--clinical profiles and pathological findings.
Neurologia medico-chirurgica 1998;38 Suppl():284-8.
1998: Nana Kawasaki; Miyako Ohta; Sumiko Hyuga; O Hashimoto; K Morimoto; Takao Hayakawa
[Study on evaluating methods for the quality control of glycoprotein products. (II)--Erythropoietin products. Part 2].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 1998;(116):117-21.
1998: M Yamamoto; Toru Kawanishi; T Kiuchi; M Ohta; I Yokota; H Ohata; K Momose; Koichi Inoue; Takao Hayakawa
Discrepant intracellular pH changes following intracellular Ca2+ increases induced by glutamate and Ca2+ ionophores in rat hippocampal neurons.
Life sciences 1998;63(1):55-63.
1998: T Fujita; Toshiki Yoshimine; Motohiko Maruno; Takao Hayakawa
Cellular dynamics of macrophages and microglial cells in reaction to stab wounds in rat cerebral cortex.
Acta neurochirurgica 1998;140(3):275-9.
1998: Masaaki Taniguchi; Amami Kato; Toshiki Yoshimine; N Shimada; H Takimoto; Takao Hayakawa
Temperature distribution produced by laser irradiation in a ventricle model. The use of airflow in neuroendoscopic surgery.
Neurological research 1998;20(1):11-4.
1997: I Kasugai; K Morimoto; Takao Hayakawa
A variant of the HL-60 cell line expressing a high level of PTP1C exhibits increased susceptibility to differentiation by phorbol 12-myristate 13-acetate.
Cancer letters 1997;120(2):223-7.
1997: H Matsumura; Toshiki Yoshimine; S Yamamoto; Motohiko Maruno; Takao Hayakawa; Y Ono; N Kondoh; M Namiki
Single solitary metastasis of the slowly progressive type of renal cell carcinoma to the choroid plexus--case report.
Neurologia medico-chirurgica 1997;37(12):916-9.
1997: Teruhide Yamaguchi; T Yamaguchi; Mieko Kogi; Yukio Yamamoto; Takao Hayakawa
Bioassay of human granulocyte colony-stimulating factor using human promyelocytic HL-60 cells.
Biological & pharmaceutical bulletin 1997;20(9):943-7.
1997: Yoshihisa Hagihara; Youichi Saitoh; H Iwata; T Taki; S Hirano; N Arita; Takao Hayakawa
Transplantation of xenogeneic cells secreting beta-endorphin for pain treatment: analysis of the ability of components of complement to penetrate through polymer capsules.
Cell transplantation 1997;6(5):527-30.
1997: Y Miyao; Kazuhiro Ikenaka; Haruhiko Kishima; M Tamura; K Nakamura; M Kurumi; Takao Hayakawa; Kiyonori Shimizu
FUT-175, a synthetic inhibitor of the complement pathway, protects against the inactivation of infectious retroviruses by human serum.
Human gene therapy 1997;8(13):1575-83.
1997: E Mabuchi; Kiyonori Shimizu; Y Miyao; Yasufumi Kaneda; Haruhiko Kishima; M Tamura; Kazuhiro Ikenaka; Takao Hayakawa
Gene delivery by HVJ-liposome in the experimental gene therapy of murine glioma.
Gene therapy 1997;4(8):768-72.
1997: AK Muhammad; Toshiki Yoshimine; Motohiko Maruno; K Tokiyoshi; O Takemoto; Takao Hayakawa
Chromosome 22q allelic losses at microsatellite loci in human astrocytic tumors.
Neurologia medico-chirurgica 1997;37(8):606-10; discussion 611.
1997: Y Miyao; Kiyonori Shimizu; M Tamura; H Akita; K Ikeda; E Mabuchi; Haruhiko Kishima; Takao Hayakawa; Kazuhiro Ikenaka
Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells.
Japanese journal of cancer research : Gann 1997;88(7):678-86.
1997: Takamichi Yuguchi; Eiji Kohmura; T Sakaki; M Nonaka; Kiyofumi Yamada; Toshihide Yamashita; T Kishiguchi; T Sakaguchi; Takao Hayakawa
Expression of growth inhibitory factor mRNA after focal ischemia in rat brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(7):745-52.
1997: AK Muhammad; Toshiki Yoshimine; Motohiko Maruno; K Tokiyoshi; O Takemoto; Hirotomo Ninomiya; Takao Hayakawa
Chromosome 17 allelic loss in astrocytic tumors and its clinico-pathologic implications.
Clinical neuropathology 1997;16(4):220-6.
1997: A Watabe; M Ohta; N Matsuyama; K Mizuno; N el Borai; T Tanimoto; Toru Kawanishi; Takao Hayakawa
Characterization of plasmin-induced platelet aggregation.
Research communications in molecular pathology and pharmacology 1997;96(3):341-52.
1997: Toshihide Yamashita; Shoichi Shimada; A Yamauchi; W Guo; Eiji Kohmura; Takao Hayakawa; Masaya Tohyama
Induction of Na+/myo-inositol co-transporter mRNA after rat cryogenic injury.
Brain research. Molecular brain research 1997;46(1-2):236-42.
1997: Hiroyuki Mizuguchi; Tsutomu Nakagawa; Y Morioka; Susumu Imazu; Mahito Nakanishi; T Kondo; Takao Hayakawa; Tadanori Mayumi
Cytoplasmic gene expression system enhances the efficiency of cationic liposome-mediated in vivo gene transfer into mouse brain.
Biochemical and biophysical research communications 1997;234(1):15-8.
1997: Takahisa Hirose; T Kuroda; Michio Otsuki; M Takagi; Hiroyasu Yamamoto; T Motomura; Shogo Kurebayashi; Y Miyashita; Masafumi Koga; Norio Arita; Takao Hayakawa; Tadamitsu Kishimoto; Soji Kasayama
A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide.
Internal medicine (Tokyo, Japan) 1997;36(5):345-50.
1997: Toshihide Yamashita; Shoichi Shimada; W Guo; K Sato; E Kohmura; Takao Hayakawa; T Takagi; Masaya Tohyama
Cloning and functional expression of a brain peptide/histidine transporter.
The Journal of biological chemistry 1997;272(15):10205-11.
1997: Shingo Niimi; Teruhide Yamaguchi; Takao Hayakawa
Regulation of glucocorticoid receptor by the tyrosine kinase inhibitor herbimycin A in the cytosolic fraction of primary cultured rat hepatocytes.
The Journal of steroid biochemistry and molecular biology 1997;61(1-2):65-71.
1997: A K M Ghulam Muhammad; Toshiki Yoshimine; Motohiko Maruno; O Takemoto; Takao Hayakawa
Topical application of fibrin adhesive in the rat brain: effects on different cellular elements of the wound.
Neurological research 1997;19(1):84-8.
1997: Shuichi Izumoto; Norio Arita; T Ohnishi; S Hiraga; T Taki; Naruya Tomita; Masayuki Ohue; Takao Hayakawa
Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas.
Cancer letters 1997;112(2):251-6.
1997: Takamichi Yuguchi; Eiji Kohmura; Kiyofumi Yamada; H Otsuki; T Sakaki; Toshihide Yamashita; M Nonaka; T Sakaguchi; Akio Wanaka; Takao Hayakawa
Expression of tPA mRNA in the facial nucleus following facial nerve transection in the rat.
Neuroreport 1997;8(2):419-22.
1997: Eiji Kohmura; Takamichi Yuguchi; T Sakaki; Toshihide Yamashita; M Nonaka; Takao Hayakawa
Altered expression of Growth Inhibitory Factor (GIF / MT-III) mRNA in the rat facial nucleus after facial nerve injury is closely related with facial function.
Restorative neurology and neuroscience 1997;11(3):169-75.
1997: Youichi Saitoh; Norio Arita; Takanori Ohnishi; S Ekramullah; K Takemura; Takao Hayakawa
Absence of apoptosis in somatotropinomas treated with octreotide.
Acta neurochirurgica 1997;139(9):851-6.
1997: T Sakaki; Eiji Kohmura; T Kishiguchi; Takamichi Yuguchi; Toshihide Yamashita; Takao Hayakawa
Loss and apoptosis of smooth muscle cells in intracranial aneurysms. Studies with in situ DNA end labeling and antibody against single-stranded DNA.
Acta neurochirurgica 1997;139(5):469-74; discussion 474-5.
1996: K Tokiyoshi; Toshiki Yoshimine; Motohiko Maruno; A K Muhammad; Takao Hayakawa
Accumulation of allelic losses on chromosome 10 in human gliomas at recurrence.
Clinical molecular pathology 1996;49(4):M218-22.
1994: T Sakaguchi; Kiyofumi Yamada; Akio Wanaka; Eiji Kohmura; Takamichi Yuguchi; Mamoru Taneda; K Kataoka; Masaya Tohyama; Takao Hayakawa
Expression of basic fibroblast growth factor receptor messenger RNA in the periinfarcted brain tissue.
Restorative neurology and neuroscience 1994;7(1):29-36.
1994: Eiji Kohmura; Takamichi Yuguchi; Kiyofumi Yamada; T Sakaguchi; Takao Hayakawa
Recombinant basic fibroblast growth factor spares thalamic neurons from retrograde degeneration after ablation of the somatosensory cortex in rats.
Restorative neurology and neuroscience 1994;6(4):309-16.