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Hirotoshi Hayasawa

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

Procedures

Administration, Oral

Disorders

Experimental Melanomas

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Publications

TOP 3
Miyuki Tanaka; Eriko Misawa; Yousuke Ito; Noriko Habara; Kouji Nomaguchi; Muneo Yamada; Tomohiro Toida; Hirotoshi Hayasawa; Mitunori Takase; Masanori Inagaki; Ryuuichi Higuchi
Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds.
Yoshihiko Ushida; Yukiko Shimokawa; Hiroshi Matsumoto; Tomohiro Toida; Hirotoshi Hayasawa
Effects of bovine alpha-lactalbumin on gastric defense mechanisms in naive rats.
Eriko Misawa; Takuma Sakurai; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Booster effect of interleukin-2 on natural killer 1.1+ cells stimulated by administration of macrophage colony-stimulating factor in mice.

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All Publications

2006: Miyuki Tanaka; Eriko Misawa; Yousuke Ito; Noriko Habara; Kouji Nomaguchi; Muneo Yamada; Tomohiro Toida; Hirotoshi Hayasawa; Mitunori Takase; Masanori Inagaki; Ryuuichi Higuchi
Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds.
Biological & pharmaceutical bulletin 2006;29(7):1418-22.
2003: Yoshihiko Ushida; Yukiko Shimokawa; Hiroshi Matsumoto; Tomohiro Toida; Hirotoshi Hayasawa
Effects of bovine alpha-lactalbumin on gastric defense mechanisms in naive rats.
Bioscience, biotechnology, and biochemistry 2003;67(3):577-83.
2003: Eriko Misawa; Takuma Sakurai; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Booster effect of interleukin-2 on natural killer 1.1+ cells stimulated by administration of macrophage colony-stimulating factor in mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2003;26(1):21-30.
2002: Takuma Sakurai; Eriko Misawa; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Comparative study and effects of macrophage colony-stimulating factor (M-CSF) administration on NK1.1+ cells in mouse spleen and bone marrow.
Immunopharmacology and immunotoxicology 2002;24(4):547-66.
2002: Shinya Suzu; Yokichi Hayashi; Tatsuo Harumi; Kouji Nomaguchi; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.
Biochemical and biophysical research communications 2002;296(5):1215-21.
2002: Yuko Mishima; Yuko Matsumoto-Mishima; Yasuhito Terui; Misa Katsuyama; Muneo Yamada; Masaki Mori; Yukihito Ishizaka; Kazuma Ikeda; Jun-ichiro Watanabe; Nobuyuki Mizunuma; Hirotoshi Hayasawa; Kiyohiko Hatake
Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.
Journal of the National Cancer Institute 2002;94(13):1020-8.
2002: Takuma Sakurai; Eriko Misawa; Miyuki Tanaka-Douzono; Hiroaki Hagesita; Kouji Nomaguchi; Kuhara Tetsuya; Shinya Suzu; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Effect of coadministration of M-CSF and IFN-alpha on NK1.1+ cells in mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(6):701-8.
2002: Yuko Mishima; Yasuhito Terui; Yuko Mishima; Misa Katsuyama; Masaki Mori; Hiroshi Tomizuka; Toshiyuki Takizawa; Akira Miyazato; Masuzu Ueda; Muneo Yamada; Hirotoshi Hayasawa; Nobuyuki Mizunuma; Yukihito Ishizaka; Kazuma Ikeda; Takashi Kato; Keiya Ozawa; Kiyohiko Hatake
New human myelodysplastic cell line, TER-3: G-CSF specific downregulation of Ca2+/calmodulin-dependent protein kinase IV.
Journal of cellular physiology 2002;191(2):183-90.
2002: Kouichirou Shin; Koji Yamauchi; Susumu Teraguchi; Hirotoshi Hayasawa; I Imoto
Susceptibility of Helicobacter pylori and its urease activity to the peroxidase-hydrogen peroxide-thiocyanate antimicrobial system.
Journal of medical microbiology 2002;51(3):231-7.
2002: M Tomita; Hiroyuki Wakabayashi; Koji Yamauchi; Susumu Teraguchi; Hirotoshi Hayasawa
Bovine lactoferrin and lactoferricin derived from milk: production and applications.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(1):109-12.
2001: Miyuki Tanaka-Douzono; Shinya Suzu; Muneo Yamada; N Wakimoto; Hirotoshi Hayasawa; Kiyohiko Hatake; Kazuo Motoyoshi
Detection of murine adult bone marrow stroma-initiating cells in Lin(-)c-fms(+)c-kit(low)VCAM-1(+) cells.
Journal of cellular physiology 2001;189(1):45-53.
2001: Hidefumi Kuwata; Koji Yamauchi; Susumu Teraguchi; Yoshihiko Ushida; Yukiko Shimokawa; Tomohiro Toida; Hirotoshi Hayasawa
Functional fragments of ingested lactoferrin are resistant to proteolytic degradation in the gastrointestinal tract of adult rats.
The Journal of nutrition 2001;131(8):2121-7.
2001: Kouji Nomaguchi; Shinya Suzu; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Expression of Jagged1 gene in macrophages and its regulation by hematopoietic growth factors.
Experimental hematology 2001;29(7):850-5.
2001: Masaki Mori; Yasuhito Terui; M Tanaka; Hiroshi Tomizuka; Yuko Mishima; M Ikeda; Tadashi Kasahara; M Uwai; Masuzu Ueda; R Inoue; T Itoh; Muneo Yamada; Hirotoshi Hayasawa; Y Furukawa; Yukihito Ishizaka; Keiya Ozawa; Kiyohiko Hatake
Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity: activation of caspase-3 and nuclear factor-kappaB.
Cancer research 2001;61(11):4414-7.
2001: H Matsumoto; Yukiko Shimokawa; Yoshihiko Ushida; Tomohiro Toida; Hirotoshi Hayasawa
New biological function of bovine alpha-lactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats.
Bioscience, biotechnology, and biochemistry 2001;65(5):1104-11.
2001: Kouichirou Shin; Hirotoshi Hayasawa; Bo Lonnerdal
Purification and quantification of lactoperoxidase in human milk with use of immunoadsorbents with antibodies against recombinant human lactoperoxidase.
The American journal of clinical nutrition 2001;73(5):984-9.
2001: Kouichirou Shin; Hirotoshi Hayasawa; Bo Lonnerdal
Inhibition of Escherichia coli respiratory enzymes by the lactoperoxidase-hydrogen peroxide-thiocyanate antimicrobial system.
Journal of applied microbiology 2001;90(4):489-93.
2001: Kouichirou Shin; Hirotoshi Hayasawa; Bo Lonnerdal
Mutations affecting the calcium-binding site of myeloperoxidase and lactoperoxidase.
Biochemical and biophysical research communications 2001;281(4):1024-9.
2000: Eriko Misawa; Takuma Sakurai; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Effects of macrophage colony-stimulating factor and interleukin-2 administration on NK1.1(+) cells in mice.
International journal of immunopharmacology 2000;22(11):967-77.
2000: M Uwai; Yasuhito Terui; Yuko Mishima; Hiroshi Tomizuka; M Ikeda; T Itoh; Masaki Mori; Masuzu Ueda; R Inoue; Muneo Yamada; Hirotoshi Hayasawa; T Horiuchi; Y Niho; M Matsumoto; Yukihito Ishizaka; Kazuma Ikeda; Keiya Ozawa; Kiyohiko Hatake
A new apoptotic pathway for the complement factor B-derived fragment Bb.
Journal of cellular physiology 2000;185(2):280-92.
2000: Shinya Suzu; Miyuki Tanaka-Douzono; Kouji Nomaguchi; Muneo Yamada; Hirotoshi Hayasawa; F Kimura; Kazuo Motoyoshi
p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction.
The EMBO journal 2000;19(19):5114-22.
2000: Hiroyuki Wakabayashi; Katsuhisa Uchida; Koji Yamauchi; Susumu Teraguchi; Hirotoshi Hayasawa; Hideyo Yamaguchi
Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models.
The Journal of antimicrobial chemotherapy 2000;46(4):595-602.
2000: Muneo Yamada; Shinya Suzu; Miyuki Tanaka-Douzono; N Wakimoto; Kiyohiko Hatake; Hirotoshi Hayasawa; Kazuo Motoyoshi
Effect of cytokines on the proliferation/differentiation of stroma-initiating cells.
Journal of cellular physiology 2000;184(3):351-5.
2000: Koji Yamauchi; Tomohiro Toida; S Nishimura; E Nagano; O Kusuoka; Susumu Teraguchi; Hirotoshi Hayasawa; S Shimamura; M Tomita
13-Week oral repeated administration toxicity study of bovine lactoferrin in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(6):503-12.
2000: Kouichirou Shin; Hirotoshi Hayasawa; Bo Lonnerdal
PCR cloning and baculovirus expression of human lactoperoxidase and myeloperoxidase.
Biochemical and biophysical research communications 2000;271(3):831-6.
2000: Koji Yamauchi; Tomohiro Toida; A Kawai; S Nishimura; Susumu Teraguchi; Hirotoshi Hayasawa
Mutagenicity of bovine lactoferrin in reverse mutation test.
The Journal of toxicological sciences 2000;25(2):63-6.
2000: Takuma Sakurai; Eriko Misawa; Muneo Yamada; Hirotoshi Hayasawa; Kazuo Motoyoshi
Effects of macrophage-colony-stimulating factor on cyclophosphamide-injected mouse NK1.1+ cell activity.
Cancer immunology, immunotherapy : CII 2000;49(2):94-100.
2000: Koji Yamauchi; M Hiruma; N Yamazaki; Hiroyuki Wakabayashi; Hidefumi Kuwata; Susumu Teraguchi; Hirotoshi Hayasawa; N Suegara; Hideyo Yamaguchi
Oral administration of bovine lactoferrin for treatment of tinea pedis. A placebo-controlled, double-blind study.
Mycoses 2000;43(5):197-202.
1999: K Takahashi; Hirotoshi Hayasawa; M Tomita
[A predictive model for affect of atopic dermatitis in infancy by neural network and multiple logistic regression].
Arerugī = [Allergy] 1999;48(11):1222-9.
1999: Hiroyuki Wakabayashi; H Matsumoto; K Hashimoto; Susumu Teraguchi; Mitsunori Takase; Hirotoshi Hayasawa
Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives.
Bioscience, biotechnology, and biochemistry 1999;63(5):955-7.
1999: Hiroyuki Wakabayashi; H Matsumoto; K Hashimoto; Susumu Teraguchi; Mitsunori Takase; Hirotoshi Hayasawa
N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity.
Antimicrobial agents and chemotherapy 1999;43(5):1267-9.
1999: T Hagiwara; K Ozawa; Y Fukuwatari; Hirotoshi Hayasawa; Y Hirohata; Akiko Adachi; K Aihara; S Kanda
Numerous huge iron particles appeared around micro blood vessels under intestinal epithelial cells in infant mice fed excess iron with protein.
Journal of submicroscopic cytology and pathology 1999;31(2):215-9.
1999: Yoshihiro Kanamaru; M Etoh; X G Song; Takashi MIKOGAMI; Hirotoshi Hayasawa; T Ebina; Nobuyuki Minamoto
A high-Mr glycoprotein fraction from cow's milk potent in inhibiting replication of human rotavirus in vitro.
Bioscience, biotechnology, and biochemistry 1999;63(1):246-9.
1998: Hidefumi Kuwata; Tai-Tung Yip; Koji Yamauchi; Susumu Teraguchi; Hirotoshi Hayasawa; M Tomita; T William Hutchens
The survival of ingested lactoferrin in the gastrointestinal tract of adult mice.
The Biochemical journal 1998;334 ( Pt 2)():321-3.
1998: H Miyauchi; S Hashimoto; M Nakajima; I Shinoda; Y Fukuwatari; Hirotoshi Hayasawa
Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain.
Cellular immunology 1998;187(1):34-7.
1998: Hiroyuki Wakabayashi; Shigeru Abe; Susumu Teraguchi; Hirotoshi Hayasawa; Hideyo Yamaguchi
Inhibition of hyphal growth of azole-resistant strains of Candida albicans by triazole antifungal agents in the presence of lactoferrin-related compounds.
Antimicrobial agents and chemotherapy 1998;42(7):1587-91.
1998: Kouichirou Shin; Koji Yamauchi; Susumu Teraguchi; Hirotoshi Hayasawa; M Tomita; Y Otsuka; S Yamazaki
Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic Escherichia coli O157:H7.
Letters in applied microbiology 1998;26(6):407-11.
1998: Y Hirohata; Akiko Adachi; K Aihara; S Kanda; T Hagiwara; K Ozawa; Y Fukuwatari; Hirotoshi Hayasawa
Investigation of morphological changes in absorptive cells in young adult and infant mice fed different amounts of iron for a long-term.
Journal of submicroscopic cytology and pathology 1998;30(2):279-83.
1998: M Nakajima; I Shinoda; Y Fukuwatari; Hirotoshi Hayasawa
Arbutin increases the pigmentation of cultured human melanocytes through mechanisms other than the induction of tyrosinase activity.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1998;11(1):12-7.
1998: Koji Yamauchi; Hiroyuki Wakabayashi; S Hashimoto; Susumu Teraguchi; Hirotoshi Hayasawa; M Tomita
Effects of orally administered bovine lactoferrin on the immune system of healthy volunteers.
Advances in experimental medicine and biology 1998;443():261-5.
1998: T Ogata; Susumu Teraguchi; Kouichirou Shin; M Kingaku; Y Fukuwatari; K Kawase; Hirotoshi Hayasawa; M Tomita
The mechanism of in vivo bacteriostasis of bovine lactoferrin.
Advances in experimental medicine and biology 1998;443():239-46.
1998: Hiroyuki Wakabayashi; T Okutomi; Shigeru Abe; Hirotoshi Hayasawa; M Tomita; Hideyo Yamaguchi
Enhanced anti-Candida activity of neutrophils and azole antifungal agents in the presence of lactoferrin-related compounds.
Advances in experimental medicine and biology 1998;443():229-37.
1998: M Tomita; Koji Yamauchi; Susumu Teraguchi; Hirotoshi Hayasawa
Host defensive effects of orally administered bovine lactoferrin.
Advances in experimental medicine and biology 1998;443():189-97.
1997: M Nakajima; I Shinoda; Takashi MIKOGAMI; H Iwamoto; S Hashimoto; H Miyauchi; Y Fukuwatari; Hirotoshi Hayasawa
Beta-lactoglobulin suppresses melanogenesis in cultured human melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1997;10(6):410-3.
1997: H Miyauchi; A Kaino; I Shinoda; Y Fukuwatari; Hirotoshi Hayasawa
Immunomodulatory effect of bovine lactoferrin pepsin hydrolysate on murine splenocytes and Peyer's patch cells.
Journal of dairy science 1997;80(10):2330-9.
1997: M Nakajima; I Shinoda; Y Samejima; H Miyauchi; Y Fukuwatari; Hirotoshi Hayasawa
A simple and quantitative cell-blotting assay for evaluation of pigmentation of cultured melanocytes and its use in demonstrating the depigmenting effect of lactoferrin.
Archives of dermatological research 1997;289(3):180-3.
1997: M Nakajima; I Shinoda; Y Samejima; H Miyauchi; Y Fukuwatari; Hirotoshi Hayasawa
Lactoferrin as a suppressor of cell migration of gastrointestinal cell lines.
Journal of cellular physiology 1997;170(2):101-5.
1996: M Nakajima; I Shinoda; Y Samejima; H Miyauchi; Y Fukuwatari; Hirotoshi Hayasawa
Kappa-casein suppresses melanogenesis in cultured pigment cells.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1996;9(5):235-9.