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Toshio Hayashi

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Toshio Hayashi; Koichiro Ina; Seinosuke Kawashima; Kiyoshi Kubota; Mitsuhiko Noda; Hideki Nomura; Hiroshi Noto; Takashi Ohrui; Hirohito Sone; Minoru Takemoto; Hiroshi Watanabe; Koutaro Yokote; Atsushi Araki
Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age.
Hiroyuki Umegaki; Madoka Yanagawa; Toshio Hayashi; Hirotaka Nakshima; Hideki Nomura; Zen Nonogaki; Masafumi Kuzuya
Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly.
Toshio Hayashi; Takahisa Hirose; Koichiro Ina; Toshiaki Kato; Hideki Nomura; Zen Nonogaki; Yusuke Suzuki
Place of death for the elderly in need of end-of-life home care: a study in Japan.

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2013: Toshio Hayashi; Koichiro Ina; Seinosuke Kawashima; Kiyoshi Kubota; Mitsuhiko Noda; Hideki Nomura; Hiroshi Noto; Takashi Ohrui; Hirohito Sone; Minoru Takemoto; Hiroshi Watanabe; Koutaro Yokote; Atsushi Araki
Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age.
Cardiovascular diabetology 2013;12(1):10.
2013: Hiroyuki Umegaki; Madoka Yanagawa; Toshio Hayashi; Hirotaka Nakshima; Hideki Nomura; Zen Nonogaki; Masafumi Kuzuya
Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly.
Geriatrics & gerontology international 2013;13(1):28-34.
2011: Toshio Hayashi; Takahisa Hirose; Koichiro Ina; Toshiaki Kato; Hideki Nomura; Zen Nonogaki; Yusuke Suzuki
Place of death for the elderly in need of end-of-life home care: a study in Japan.
Archives of gerontology and geriatrics 2011;53(2):242-4.
2011: Toshio Hayashi
[Estrogen, SERM].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(7):1270-4.
2011: Koichiro Ina; Asako Ishitsuka; Hideki Nomura; Toshio Hayashi; Hisako Hirai; Akihisa Iguchi
Depression, quality of life (QoL) and will to live of community-dwelling postmenopausal women in three Asian countries: Korea, China and Japan.
Archives of gerontology and geriatrics 2011;53(1):8-12.
2011: Hisako Matsui-Hirai; Toshio Hayashi; Seiji Yamamoto; Koichiro Ina; Morihiko Maeda; Hitoshi Kotani; Akihisa Iguchi; Louis J Ignarro; Yuichi Hattori
Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide.
The Journal of pharmacology and experimental therapeutics 2011;337(3):591-9.
2011: Toshio Hayashi; Koichiro Ina; Morihiko Maeda; Hideki Nomura
The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;24(4):199-203.
2011: Toshio Hayashi; Koichiro Ina; Hideki Itoh; Seinosuke Kawashima; Kiyoshi Kubota; Hideki Nomura; Takashi Ohrui; Hirohito Sone; Hiroshi Watanabe; Koutaro Yokote; Masao Yoshizumi; Yoshiyuki Hattori
Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients.
Cardiovascular diabetology 2011;10():86.
2010: Noriaki Kishimoto; Toshio Hayashi; Ichiro Sakuma; Hatsuyo Kano-Hayashi; Taku Tsunekawa; Masako Osawa; Kouichiro Ina; Akihisa Iguchi
A hydroxymethylglutaryl coenzyme A reductase inhibitor improves endothelial function within 7 days in patients with chronic hemodialysis.
International journal of cardiology 2010;145(1):21-6.
2010: Toshio Hayashi; Akihisa Iguchi
Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers.
Geriatrics & gerontology international 2010;10(2):115-30.
2009: Jun Funami; Toshio Hayashi; Hideki Nomura; Qun-Fang Ding; Asako Ishitsuka-Watanabe; Hisako Matsui-Hirai; Koichiro Ina; Jie Zhang; Ze-Yun Yu; Akihisa Iguchi
Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women.
Life sciences 2009;85(7-8):316-21.
2009: Toshio Hayashi; Seinosuke Kawashima; Hideki Itoh; Nobuhiro Yamada; Hirohito Sone; Hiroshi Watanabe; Yoshiyuki Hattori; Takashi Ohrui; Koutaro Yokote; Hideki Nomura; Hiroyuki Umegaki; Akihisa Iguchi
Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages.
Diabetes care 2009;32(7):1221-3.
2008: Toshio Hayashi; Kumiko Yano; Hisako Matsui-Hirai; Hiroki Yokoo; Yuichi Hattori; Akihisa Iguchi
Nitric oxide and endothelial cellular senescence.
Pharmacology & therapeutics 2008;120(3):333-9.
2008: Toshio Hayashi; Seinosuke Kawashima; Hideki Itoh; Nobuhiro Yamada; Hirohito Sone; Hiroshi Watanabe; Yoshiyuki Hattori; Takashi Ohrui; Masashi Yoshizumi; Koutaro Yokote; Kiyoshi Kubota; Hideki Nomura; Hiroyuki Umegaki; Akihisa Iguchi
Importance of lipid levels in elderly diabetic individuals: baseline characteristics and 1-year survey of cardiovascular events.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(2):218-25.
2007: Toshio Hayashi; Koutaro Yokote; Yasushi Saito; Akihisa Iguchi
Pitavastatin: efficacy and safety in intensive lipid lowering.
Expert opinion on pharmacotherapy 2007;8(14):2315-27.
2007: Qun-Fang Ding; Toshio Hayashi; Xin-Jun Zhang; Jun Funami; Ling Ge; Jun Li; Xiao-Li Huang; Li Cao; Jun Zhang; Iguchi Akihisa
Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopausal women.
Journal of diabetes and its complications 2007;21(5):315-9.
2007: Toshio Hayashi; Hideki Nomura; Masako Osawa; Jun Funami; Asaka Miyazaki; Akihisa Iguchi
Nitric oxide metabolites are associated with survival in older patients.
Journal of the American Geriatrics Society 2007;55(9):1398-403.
2007: Toshio Hayashi
[Hormone replacement Up-to-date. The effect of estrogen on vascular function and atherosclerosis].
Clinical calcium 2007;17(9):1355-63.
2007: Toshio Hayashi
[Pathophysiology and treatment strategy for post-menopausal hyperlipidemia].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():522-6.
2007: Akiko Fukatsu; Toshio Hayashi; Asaka Miyazaki-Akita; Hisako Matsui-Hirai; Yukie Furutate; Asako Ishitsuka; Yuichi Hattori; Akihisa Iguchi
Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H790-7.
2007: Toshio Hayashi; Packiasamy A R Juliet; Asaka Miyazaki; Louis J Ignarro; Akihisa Iguchi
High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis.
Biochimica et biophysica acta 2007;1772(3):364-72.
2007: Asaka Miyazaki-Akita; Toshio Hayashi; Qun-Fang Ding; Hiroaki Shiraishi; Takahide Nomura; Yuichi Hattori; Akihisa Iguchi
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.
The Journal of pharmacology and experimental therapeutics 2007;320(2):591-8.
2007: Masako Osawa; Toshio Hayashi; Hideki Nomura; Jun Funami; Asaka Miyazaki; Louis J Ignarro; Akihisa Iguchi
Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;16(1):157-63.
2007: Toshio Hayashi; Packiasamy A R Juliet; Asaka Miyazaki-Akita; Jun Funami; Hisako Matsui-Hirai; Akiko Fukatsu; Akihisa Iguchi
beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes.
Life sciences 2007;80(6):592-9.
2006: Toshio Hayashi; Hisako Matsui-Hirai; Asaka Miyazaki-Akita; Akiko Fukatsu; Jun Funami; Qun-Fang Ding; Sumitra Kamalanathan; Yuichi Hattori; Louis J Ignarro; Akihisa Iguchi
Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):17018-23.
2006: Toshio Hayashi; Hisako Matsui-Hirai; Akiko Fukatsu; Daigo Sumi; Hatsuyo Kano-Hayashi; Juliet Arockia Rani P; Akihisa Iguchi
Selective iNOS inhibitor, ONO1714 successfully retards the development of high-cholesterol diet induced atherosclerosis by novel mechanism.
Atherosclerosis 2006;187(2):316-24.
2006: Toshio Hayashi; Teiji Esaki; Daigo Sumi; Tapan Mukherjee; Akihisa Iguchi; Gautam Chaudhuri
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10485-90.
2005: Toshio Hayashi; Packiasamy A R Juliet; Hisako Matsui-Hirai; Asaka Miyazaki; Akiko Fukatsu; Jun Funami; Akihisa Iguchi; Louis J Ignarro
l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13681-6.
2005: Toshio Hayashi; Hideki Nomura; Teiji Esaki; Ayako Hattori; Hatsuyo Kano-Hayashi; Akihisa Iguchi
The treadmill exercise-tolerance test is useful for the prediction and prevention of ischemic coronary events in elderly diabetics.
Journal of diabetes and its complications 2005;19(5):264-8.
2005: Toshio Hayashi; Packiasamy A R Juliet; Hatsuyo Kano-Hayashi; Taku Tsunekawa; D Dingqunfang; Daigo Sumi; Hisako Matsui-Hirai; Akiko Fukatsu; Akihisa Iguchi
NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction.
Diabetes, obesity & metabolism 2005;7(4):334-43.
2004: Qun-Fang Ding; Toshio Hayashi; A R Juliet Packiasamy; Asaka Miyazaki; Akiko Fukatsu; Hiroaki Shiraishi; Takahide Nomura; Akihisa Iguchi
The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase.
Life sciences 2004;75(26):3185-94.
2004: Toshio Hayashi; Juliet Arockia Rani P; Akiko Fukatsu; Hisako Matsui-Hirai; Masako Osawa; Asaka Miyazaki; Taku Tsunekawa; Hatsuyo Kano-Hayashi; Akihisa Iguchi; Daigo Sumi; Louis J Ignarro
A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits.
Atherosclerosis 2004;176(2):255-63.
2004: Packiasamy A R Juliet; Toshio Hayashi; Sumi Daigo; Hisako Matsui-Hirai; Asaka Miyazaki; Akiko Fukatsu; Jun Funami; Akihisa Iguchi; Louis J Ignarro
Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells.
Biochimica et biophysica acta 2004;1693(3):185-91.
2004: Toshio Hayashi; Akihisa Iguchi
[Diabetic macroangiopathy and NO].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():548-54.
2004: Toshio Hayashi
[Anti-thrombotic effect of nitric oxide].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():505-9.
2004: Toshio Hayashi
[From the standpoint in department of geriatrics in university hospital].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2004;41(3):294-7.
2004: Toshio Hayashi; Daigo Sumi; Packiasamy A R Juliet; Hisako Matsui-Hirai; Yukako Asai-Tanaka; Hatsuyo Kano; Akiko Fukatsu; Taku Tsunekawa; Asaka Miyazaki; Akihisa Iguchi; Louis J Ignarro
Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits.
Cardiovascular research 2004;61(2):339-51.
2003: Packiasamy A R Juliet; Toshio Hayashi; Akihisa Iguchi; Louis J Ignarro
Concomitant production of nitric oxide and superoxide in human macrophages.
Biochemical and biophysical research communications 2003;310(2):367-70.
2003: Daigo Sumi; Toshio Hayashi; Hisako Matsui-Hirai; Aaron T Jacobs; Louis J Ignarro; Akihisa Iguchi
17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells.
Biochimica et biophysica acta 2003;1640(2-3):113-8.
2003: Toshio Hayashi; Daigo Sumi; Hisako Matsui-Hirai; Akiko Fukatsu; Juliet Arockia Rani P; Hatsuyo Kano; Taku Tsunekawa; Akihisa Iguchi
Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism.
Atherosclerosis 2003;168(1):23-31.
2003: Taku Tsunekawa; Toshio Hayashi; Yusuke Suzuki; Hisako Matsui-Hirai; Hatsuyo Kano; Akiko Fukatsu; Noriko Nomura; Asaka Miyazaki; Akihisa Iguchi
Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects.
Diabetes care 2003;26(2):285-9.
2002: Toshio Hayashi
[Quality of life in elderly with atherosclerotic diseases].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2002;39(4):404-8.
2002: Hatsuyo Kano; Toshio Hayashi; Daigo Sumi; Hisako Matusi-Hirai; Taku Tsunekawa; Hidetoshi Endo; Akihisa Iguchi
Estriol retards and stabilizes atherosclerosis through an NO-mediated system.
Life sciences 2002;71(1):31-42.
2002: Navin Kumar Thakur; Toshio Hayashi; Daigo Sumi; Hatsuyo Kano; Hisako Matsui-Hirai; Taku Tsunekawa; Akihisa Iguchi
Anti-atherosclerotic effect of beta-blocker with nitric oxide-releasing action on the severe atherosclerosis.
Journal of cardiovascular pharmacology 2002;39(2):298-309.
2001: M Jayachandran; Toshio Hayashi; Daigo Sumi; Akihisa Iguchi; V M Miller
Temporal effects of 17beta-estradiol on caveolin-1 mRNA and protein in bovine aortic endothelial cells.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1327-33.
2001: Daigo Sumi; Toshio Hayashi; M Jayachandran; Akihisa Iguchi
Estrogen prevents destabilization of endothelial nitric oxide synthase mRNA induced by tumor necrosis factor alpha through estrogen receptor mediated system.
Life sciences 2001;69(14):1651-60.
2001: Taku Tsunekawa; Toshio Hayashi; Hatsuyo Kano; Daigo Sumi; Hisako Matsui-Hirai; Navin Kumar Thakur; K Egashira; Akihisa Iguchi
Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days.
Circulation 2001;104(4):376-9.
2001: Navin Kumar Thakur; Toshio Hayashi; Daigo Sumi; Hatsuyo Kano; Taku Tsunekawa; Akihisa Iguchi
HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide.
American journal of physiology. Heart and circulatory physiology 2001;281(1):H75-83.
2001: Daigo Sumi; Toshio Hayashi; Navin Kumar Thakur; M Jayachandran; Y Asai; Hatsuyo Kano; Hideo Matsui; Akihisa Iguchi
A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects--the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action.
Atherosclerosis 2001;155(2):347-57.
2001: M Jayachandran; Toshio Hayashi; Daigo Sumi; Navin Kumar Thakur; Hatsuyo Kano; Louis J Ignarro; Akihisa Iguchi
Up-regulation of endothelial nitric oxide synthase through beta(2)-adrenergic receptor--the role of a beta-blocker with NO-releasing action.
Biochemical and biophysical research communications 2001;280(3):589-94.
2000: Teiji Esaki; Toshio Hayashi; E Muto; Hatsuyo Kano; T N Kumar; Y Asai; Daigo Sumi; Akihisa Iguchi
Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2000;4(6):561-71.
2000: Osamu Ogawa; Hiroyuki Umegaki; Daigo Sumi; Toshio Hayashi; A Nakamura; Navin Kumar Thakur; Juri Yoshimura; Hidetoshi Endo; Akihisa Iguchi
Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells.
European journal of pharmacology 2000;408(2):137-41.
2000: Toshio Hayashi; M Jayachandran; Daigo Sumi; Navin Kumar Thakur; Teiji Esaki; E Muto; Hatsuyo Kano; Y Asai; Akihisa Iguchi
Physiological concentration of 17beta-estradiol retards the progression of severe atherosclerosis induced by a high-cholesterol diet plus balloon catheter injury: role of NO.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1613-21.
2000: Toshio Hayashi; I Ito; Hatsuyo Kano; Hidetoshi Endo; Akihisa Iguchi
Estriol (E3) replacement improves endothelial function and bone mineral density in very elderly women.
The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(4):B183-90; discussion B191-3.
2000: Toshio Hayashi; Teiji Esaki; E Muto; Hatsuyo Kano; Y Asai; Navin Kumar Thakur; Daigo Sumi; M Jayachandran; Akihisa Iguchi
Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(3):782-92.
1999: Toshio Hayashi; Kiyofumi Yamada; Teiji Esaki; Hatsuyo Kano; Y Asai; N Kumar Thakur; M Jayachandran; Daigo Sumi; Akihisa Iguchi
Endothelium-dependent relaxation of rabbit atherosclerotic aorta was not restored by control of hyperlipidemia: the possible role of peroxynitrite (ONOO(-)).
Atherosclerosis 1999;147(2):349-63.
1999: Hatsuyo Kano; Toshio Hayashi; Daigo Sumi; Teiji Esaki; Y Asai; Navin Kumar Thakur; M Jayachandran; Akihisa Iguchi
A HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA.
Biochemical and biophysical research communications 1999;259(2):414-9.
1998: MA Ramos; Masafumi Kuzuya; Teiji Esaki; S Miura; S Satake; Toru Asai; Shigeru Kanda; Toshio Hayashi; Akihisa Iguchi
Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(7):1188-96.
1998: Toshio Hayashi; Kiyofumi Yamada; Teiji Esaki; E Muto; G Chaudhuri; Akihisa Iguchi
Physiological concentrations of 17beta-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system.
Journal of cardiovascular pharmacology 1998;31(2):292-8.
1997: Teiji Esaki; Toshio Hayashi; E Muto; Kiyofumi Yamada; Masafumi Kuzuya; Akihisa Iguchi
Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits.
Atherosclerosis 1997;128(1):39-46.
1997: Teiji Esaki; Toshio Hayashi; Y Asai; T N Kumar; Hatsuyo Kano; E Muto; Akihisa Iguchi
Expression of inducible nitric oxide synthase in T lymphocytes and macrophages in vessels with advanced atherosclerosis.
Heart and vessels 1997;Suppl 12():89-92.
1997: Toshio Hayashi; Kiyofumi Yamada; Teiji Esaki; E Muto; Akihisa Iguchi
The beta adrenoreceptor antagonist, nipradilol, preserves the endothelial nitric oxide response in atherosclerotic vessels of rabbit.
Life sciences 1997;61(14):1379-87.
1997: Toshio Hayashi; Kiyofumi Yamada; Teiji Esaki; E Mutoh; Akihisa Iguchi
Effect of estrogen on isoforms of nitric oxide synthase: possible mechanism of anti-atherosclerotic effect of estrogen.
Gerontology 1997;43 Suppl 1():24-34.
1996: Masafumi Kuzuya; S Satake; H Miura; Toshio Hayashi; Akihisa Iguchi
Inhibition of endothelial cell differentiation on a glycosylated reconstituted basement membrane complex.
Experimental cell research 1996;226(2):336-45.
1996: E Muto; Toshio Hayashi; K Yamada; Teiji Esaki; M Sagai; Akihisa Iguchi
Endothelial-constitutive nitric oxide synthase exists in airways and diesel exhaust particles inhibit the effect of nitric oxide.
Life sciences 1996;59(18):1563-70.
1996: K Yamada; Toshio Hayashi; Masafumi Kuzuya; Michitaka Naito; K Asai; Akihisa Iguchi
Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1.
Artery 1996;22(1):24-35.
1995: Kazuro Fujimoto; Keiko Yamamura; Toshio Hayashi; T Osada; T Sakurai
Effect of levofloxacin-albumin Dacron graft on graft infection.
Japanese journal of pharmacology 1995;69(4):443-5.
1995: Toshio Hayashi; K Yamada; Teiji Esaki; Masafumi Kuzuya; S Satake; T Ishikawa; H Hidaka; Akihisa Iguchi
Estrogen increases endothelial nitric oxide by a receptor-mediated system.
Biochemical and biophysical research communications 1995;214(3):847-55.
1995: Masafumi Kuzuya; S Satake; Teiji Esaki; K Yamada; Toshio Hayashi; Michitaka Naito; K Asai; Akihisa Iguchi
Induction of angiogenesis by smooth muscle cell-derived factor: possible role in neovascularization in atherosclerotic plaque.
Journal of cellular physiology 1995;164(3):658-67.
1995: I Ito; Toshio Hayashi; K Yamada; Masafumi Kuzuya; M Naito; Akihisa Iguchi
Physiological concentration of estradiol inhibits polymorphonuclear leukocyte chemotaxis via a receptor mediated system.
Life sciences 1995;56(25):2247-53.
1994: Toshio Hayashi; T Ishikawa; K Yamada; Masafumi Kuzuya; M Naito; H Hidaka; Akihisa Iguchi
Biphasic effect of estrogen on neuronal constitutive nitric oxide synthase via Ca(2+)-calmodulin dependent mechanism.
Biochemical and biophysical research communications 1994;203(2):1013-9.
1994: K Yamada; Toshio Hayashi; Takaaki Hasegawa; S Ishihara; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori; T Nabeshima
Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (2): changes in GABAA and benzodiazepine receptor binding.
Japanese journal of pharmacology 1994;66(1):53-8.
1994: S Ishihara; K Yamada; Toshio Hayashi; Takaaki Hasegawa; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori; T Nabeshima
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding.
Biological & pharmaceutical bulletin 1994;17(8):1132-4.
1994: Toshio Hayashi; K Yamada; Takaaki Hasegawa; S Ishihara; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori; T Nabeshima
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (1): Changes in the [3H]QNB binding.
Japanese journal of pharmacology 1994;64(4):303-6.
1994: T Nabeshima; K Yamada; Toshio Hayashi; Takaaki Hasegawa; S Ishihara; T Kameyama; T Morimasa; T Kaneyuki; T Shohmori
Changes in muscarinic cholinergic, PCP, GABAA, D1, and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats.
Life sciences 1994;55(20):1585-93.
1994: Michitaka Naito; K Yamada; Toshio Hayashi; K Asai; N Yoshimine; Akihisa Iguchi
Comparative toxicity of oxidatively modified low-density lipoprotein and lysophosphatidylcholine in cultured vascular endothelial cells.
Heart and vessels 1994;9(4):183-7.
1994: Toshio Hayashi; T Ishikawa; Masafumi Kuzuya; Michitaka Naito; K Yamada; K Asai; H Hidaka; Akihisa Iguchi
Chelation of copper reduces inhibition by oxidized lipoproteins of endothelium-dependent relaxation in porcine coronary arteries.
Heart and vessels 1994;9(6):283-91.
1993: K Asai; C Funaki; Toshio Hayashi; K Yamada; Michitaka Naito; Masafumi Kuzuya; F Yoshida; N Yoshimine; F Kuzuya
Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits. Possible mechanisms.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(6):892-9.
1993: K Yamada; Michitaka Naito; Toshio Hayashi; K Asai; N Yoshimine; Akihisa Iguchi
Effects of dexamethasone on migration of human monocytes in response to oxidized beta-very low density lipoprotein.
Artery 1993;20(5):253-67.
1993: Michitaka Naito; Toshio Hayashi; K Yamada; K Asai; N Yoshimine; Akihisa Iguchi
Protective effects of idebenone on vascular endothelial cells against toxicity induced by oxidatively modified low density lipoprotein.
Artery 1993;20(6):314-23.
1992: Michitaka Naito; C Funaki; Toshio Hayashi; K Yamada; K Asai; N Yoshimine; F Kuzuya
Substrate-bound fibrinogen, fibrin and other cell attachment-promoting proteins as a scaffold for cultured vascular smooth muscle cells.
Atherosclerosis 1992;96(2-3):227-34.
1992: Michitaka Naito; M Yasue; K Asai; K Yamada; Toshio Hayashi; Masafumi Kuzuya; C Funaki; N Yoshimine; F Kuzuya
Effects of dexamethasone on experimental atherosclerosis in cholesterol-fed rabbits.
Journal of nutritional science and vitaminology 1992;38(3):255-64.
1992: Masafumi Kuzuya; K Yamada; Toshio Hayashi; C Funaki; Michitaka Naito; K Asai; F Kuzuya
Role of lipoprotein-copper complex in copper catalyzed-peroxidation of low-density lipoprotein.
Biochimica et biophysica acta 1992;1123(3):334-41.
1992: Toshio Hayashi; N Yoshimine; Michitaka Naito; C Funaki; K Yamada; K Asai; F Kuzuya
HDL does not promote cholesterol efflux from macrophages of hypercholesterolemic rabbit: efflux differences between species.
Artery 1992;19(4):184-98.
1991: Masafumi Kuzuya; K Yamada; Toshio Hayashi; C Funaki; Michitaka Naito; K Asai; F Kuzuya
Oxidation of low-density lipoprotein by copper and iron in phosphate buffer.
Biochimica et biophysica acta 1991;1084(2):198-201.
1991: Michitaka Naito; Toshio Hayashi; C Funaki; Masafumi Kuzuya; K Asai; K Yamada; F Kuzuya
Vitronectin-induced haptotaxis of vascular smooth muscle cells in vitro.
Experimental cell research 1991;194(1):154-6.
1991: Toshio Hayashi; T Ishikawa; Michitaka Naito; Masafumi Kuzuya; C Funaki; K Asai; H Hidaka; F Kuzuya
Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators.
Atherosclerosis 1991;87(1):23-38.
1991: Masafumi Kuzuya; Michitaka Naito; C Funaki; Toshio Hayashi; K Asai; F Kuzuya
Lipid peroxide and transition metals are required for the toxicity of oxidized low density lipoprotein to cultured endothelial cells.
Biochimica et biophysica acta 1991;1096(2):155-61.
1991: Masafumi Kuzuya; Michitaka Naito; C Funaki; Toshio Hayashi; K Asai; F Kuzuya
Probucol prevents oxidative injury to endothelial cells.
Journal of lipid research 1991;32(2):197-204.
1991: Masafumi Kuzuya; Michitaka Naito; C Funaki; Toshio Hayashi; K Yamada; K Asai; F Kuzuya
Antioxidants stimulate endothelial cell proliferation in culture.
Artery 1991;18(3):115-24.
1991: K Asai; Toshio Hayashi; C Funaki; Masafumi Kuzuya; Michitaka Naito; F Kuzuya
Comparison of plasma clearance of low density lipoprotein with beta-very low density lipoprotein or acetoacetylated low density lipoprotein in cholesterol-fed rabbits.
Biochemistry international 1991;23(2):327-34.
1990: Masafumi Kuzuya; Michitaka Naito; K Yamada; C Funaki; Toshio Hayashi; K Asai; F Kuzuya
Involvement of intracellular iron in the toxicity of oxidized low density lipoprotein to cultured endothelial cells.
Biochemistry international 1990;22(3):567-73.
1990: Michitaka Naito; Toshio Hayashi; Masafumi Kuzuya; C Funaki; K Asai; F Kuzuya
Effects of fibrinogen and fibrin on the migration of vascular smooth muscle cells in vitro.
Atherosclerosis 1990;83(1):9-14.
1990: K Asai; Toshio Hayashi; Masafumi Kuzuya; C Funaki; Michitaka Naito; F Kuzuya
Delayed clearance of beta-very low density lipoprotein after feeding cholesterol to splenectomized rabbits.
Artery 1990;18(1):32-46.
1989: Masafumi Kuzuya; M Naito; C Funaki; Toshio Hayashi; K Asai; F Kuzuya
Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells.
Biochemical and biophysical research communications 1989;163(3):1466-72.
1989: Toshio Hayashi; Michitaka Naito; Masafumi Kuzuya; C Funaki; T Tateishi; K Asai; F Kuzuya
Role of platelet secretory products in modified lipoprotein metabolism in macrophages.
Artery 1989;16(5):248-62.
1989: Michitaka Naito; Toshio Hayashi; Masafumi Kuzuya; C Funaki; K Asai; F Kuzuya
Vascular endothelial cell migration in vitro roles of cyclic nucleotides, calcium ion and cytoskeletal system.
Artery 1989;17(1):21-31.
1989: Toshio Hayashi; Michitaka Naito; T Ishikawa; Masafumi Kuzuya; C Funaki; T Tateishi; K Asai; H Hidaka; F Kuzuya
Beta-migrating very low density lipoprotein attenuates endothelium-dependent relaxation in rabbit atherosclerotic aortas.
Blood vessels 1989;26(5):290-9.
1988: Michitaka Naito; Toshio Hayashi; C Funaki; Masafumi Kuzuya; K Asai; F Kuzuya
Chemotactic response of vascular smooth muscle cells to acetoacetylated low-density lipoprotein.
Heart and vessels 1988;4(2):100-3.