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Ravi Acharya

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
21
Leonidas, Demetres
20
Shapiro, Robert
19
Papageorgiou, Anastassios
16
Oikonomakos, Nikos
16
Brew, Keith
14
Holloway, Daniel
12
Swaminathan, Jawahar
11
Natesh, Ramanathan
11
Stuart, David
11
Sturrock, Edward
10
Thiyagarajan, Nethaji
10
Tranter, Howard
10
Johnson, Louise
9
Baker, Matthew
9
Barford, David

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Publications

TOP 3
Holloway Daniel E; Chavali Gayatri B; Leonidas Demetres D; Baker Matthew D; Acharya K Ravi
Influence of naturally-occurring 5'-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic study.
Sundriyal Amit; Roberts April K; Shone Clifford C; Acharya K Ravi
Structural basis for substrate recognition in the enzymatic component of ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
Mitsiki Eirini; Papageorgiou Anastassios C; Iyer Shalini; Thiyagarajan Nethaji; Prior Steven H; Sleep Darrell; Finnis Chris; Acharya K Ravi
Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

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All Publications

2009: Holloway Daniel E; Chavali Gayatri B; Leonidas Demetres D; Baker Matthew D; Acharya K Ravi
Influence of naturally-occurring 5'-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic study.
Biopolymers 2009;91(12):995-1008.
2009: Sundriyal Amit; Roberts April K; Shone Clifford C; Acharya K Ravi
Structural basis for substrate recognition in the enzymatic component of ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
The Journal of biological chemistry 2009;284(42):28713-9.
2009: Mitsiki Eirini; Papageorgiou Anastassios C; Iyer Shalini; Thiyagarajan Nethaji; Prior Steven H; Sleep Darrell; Finnis Chris; Acharya K Ravi
Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.
Biochemical and biophysical research communications 2009;386(4):666-70.
2009: Jamaluddin Haryati; Tumbale Percy; Ferns Tyrone A; Thiyagarajan Nethaji; Brew Keith; Acharya K Ravi
Crystal structure of alpha-1,3-galactosyltransferase (alpha3GT) in a complex with p-nitrophenyl-beta-galactoside (pNPbetaGal).
Biochemical and biophysical research communications 2009;385(4):601-4.
2009: Masuyer Geoffrey; Thiyagarajan Nethaji; James Peter L; Marks Philip M H; Chaddock John A; Acharya K Ravi
Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A.
Biochemical and biophysical research communications 2009;381(1):50-3.
2008: Leonard Philip; Scotney Pierre D; Jabeen Talat; Iyer Shalini; Fabri Louis J; Nash Andrew D; Acharya K Ravi
Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment.
Journal of molecular biology 2008;384(5):1203-17.
2008: Tumbale Percy; Jamaluddin Haryati; Thiyagarajan Nethaji; Acharya K Ravi; Brew Keith
Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase.
Glycobiology 2008;18(12):1036-43.
2008: Holbourn Kenneth P; Acharya K Ravi; Perbal Bernard
The CCN family of proteins: structure-function relationships.
Trends in biochemical sciences 2008;33(10):461-73.
2008: Ulrich Martina; Petre Alina; Youhnovski Nikolay; Prömm Franziska; Schirle Markus; Schumm Michael; Pero Ralph S; Doyle Alfred; Checkel James; Kita Hirohito; Thiyagarajan Nethaji; Acharya K Ravi; Schmid-Grendelmeier Peter; Simon Hans-Uwe; Schwarz Heinz; Tsutsui Masato; Shimokawa Hiroaki; Bellon Gabriel; Lee James J; Przybylski Michael; Döring Gerd
Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.
The Journal of biological chemistry 2008;283(42):28629-40.
2008: Tumbale Percy; Jamaluddin Haryati; Thiyagarajan Nethaji; Brew Keith; Acharya K Ravi
Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity.
Biochemistry 2008;47(33):8711-8.
2008: Jabeen Talat; Leonard Philip; Jamaluddin Haryati; Acharya K Ravi
Structure of mouse IP-10, a chemokine.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 6):611-9.
2008: Kazakou Konstantina; Holloway Daniel E; Prior Stephen H; Subramanian Vasanta; Acharya K Ravi
Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications.
Journal of molecular biology 2008;380(1):206-22.
2008: Subramanian Vasanta; Crabtree Benedict; Acharya K Ravi
Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons.
Human molecular genetics 2008;17(1):130-49.
2007: Crabtree Benedict; Thiyagarajan Nethaji; Prior Stephen H; Wilson Peter; Iyer Shalini; Ferns Tyrone; Shapiro Robert; Brew Keith; Subramanian Vasanta; Acharya K Ravi
Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.
Biochemistry 2007;46(42):11810-8.
2007: Hamze Asmaa B; Wei Shuo; Bahudhanapati Harinath; Kota Smitha; Acharya K Ravi; Brew Keith
Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors.
Protein science : a publication of the Protein Society 2007;16(9):1905-13.
2007: Singh Umesh P; Ardelt Wojciech; Saxena Shailendra K; Holloway Daniel E; Vidunas Eugene; Lee Hung-Suen; Saxena Abha; Shogen Kuslima; Acharya K Ravi
Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes.
Journal of molecular biology 2007;371(1):93-111.
2007: Jamaluddin Haryati; Tumbale Percy; Withers Stephen G; Acharya K Ravi; Brew Keith
Conformational changes induced by binding UDP-2F-galactose to alpha-1,3 galactosyltransferase- implications for catalysis.
Journal of molecular biology 2007;369(5):1270-81.
2007: Corradi Hazel R; Chitapi Itai; Sewell B Trevor; Georgiadis Dimitris; Dive Vincent; Sturrock Edward D; Acharya K Ravi
The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Biochemistry 2007;46(18):5473-8.
2007: Crabtree Benedict; Holloway Daniel E; Baker Matthew D; Acharya K Ravi; Subramanian Vasanta
Biological and structural features of murine angiogenin-4, an angiogenic protein.
Biochemistry 2007;46(9):2431-43.
2007: Rummel Andreas; Eichner Timo; Weil Tanja; Karnath Tino; Gutcaits Aleksandrs; Mahrhold Stefan; Sandhoff Konrad; Proia Richard L; Acharya K Ravi; Bigalke Hans; Binz Thomas
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):359-64.
2007: Iyer Shalini; Wei Shuo; Brew Keith; Acharya K Ravi
Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1.
The Journal of biological chemistry 2007;282(1):364-71.
2006: Corradi Hazel R; Corrigall Anne V; Boix Ester; Mohan C Gopi; Sturrock Edward D; Meissner Peter N; Acharya K Ravi
Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen.
The Journal of biological chemistry 2006;281(50):38625-33.
2006: Watermeyer Jean M; Sewell B Trevor; Schwager Sylva L; Natesh Ramanathan; Corradi Hazel R; Acharya K Ravi; Sturrock Edward D
Structure of testis ACE glycosylation mutants and evidence for conserved domain movement.
Biochemistry 2006;45(42):12654-63.
2006: Holbourn Kenneth P; Shone Clifford C; Acharya K R
A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins.
The FEBS journal 2006;273(20):4579-93.
2006: Iyer Shalini; Visse Robert; Nagase Hideaki; Acharya K Ravi
Crystal structure of an active form of human MMP-1.
Journal of molecular biology 2006;362(1):78-88.
2006: Mandron Marie; Ariès Marie-Françoise; Brehm Rossalyn D; Tranter Howard S; Acharya K Ravi; Charveron Marie; Davrinche Christian
Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote TH2 cell polarization.
The Journal of allergy and clinical immunology 2006;117(5):1141-7.
2006: Greenway Matthew J; Andersen Peter M; Russ Carsten; Ennis Sean; Cashman Susan; Donaghy Colette; Patterson Victor; Swingler Robert; Kieran Dairin; Prehn Jochen; Morrison Karen E; Green Andrew; Acharya K Ravi; Brown Robert H; Hardiman Orla
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.
Nature genetics 2006;38(4):411-3.
2006: Corradi Hazel R; Schwager Sylva L U; Nchinda Aloysius T; Sturrock Edward D; Acharya K Ravi
Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.
Journal of molecular biology 2006;357(3):964-74.
2006: Baker Matthew D; Holloway Daniel E; Swaminathan G Jawahar; Acharya K Ravi
Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.
Biochemistry 2006;45(2):416-26.
2005: Holloway Daniel E; Chavali Gayatri B; Hares Michelle C; Subramanian Vasanta; Acharya K Ravi
Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 12):1568-78.
2005: Swaminathan G Jawahar; Myszka David G; Katsamba Phinikoula S; Ohnuki Lyo E; Gleich Gerald J; Acharya K Ravi
Eosinophil-granule major basic protein, a C-type lectin, binds heparin.
Biochemistry 2005;44(43):14152-8.
2005: Sundara Baalaji N; Acharya K Ravi; Singh T P; Krishnaswamy S
High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 8):773-5.
2005: Lloyd Matthew D; Thiyagarajan Nethaji; Ho Yaik T; Woo L W Lawrence; Sutcliffe Oliver B; Purohit Atul; Reed Michael J; Acharya K Ravi; Potter Barry V L
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.
Biochemistry 2005;44(18):6858-66.
2005: Holbourn Kenneth P; Sutton J Mark; Evans Hazel R; Shone Clifford C; Acharya K Ravi
Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(15):5357-62.
2005: Iyer Shalini; Holloway Daniel E; Kumar Kapil; Shapiro Robert; Acharya K Ravi
Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor.
Journal of molecular biology 2005;347(3):637-55.
2005: Balyasnikova Irina V; Woodman Zenda L; Albrecht Ronald F; Natesh Ramanathan; Acharya K Ravi; Sturrock Edward D; Danilov Sergei M
Localization of an N-domain region of angiotensin-converting enzyme involved in the regulation of ectodomain shedding using monoclonal antibodies.
Journal of proteome research 2005;4(2):258-67.
2005: Jenkins Cara L; Thiyagarajan Nethaji; Sweeney Rozamond Y; Guy Michael P; Kelemen Bradley R; Acharya K Ravi; Raines Ronald T
Binding of non-natural 3'-nucleotides to ribonuclease A.
The FEBS journal 2005;272(3):744-55.
2005: Lloyd Matthew D; Pederick Richard L; Natesh Ramanathan; Woo L W Lawrence; Purohit Atul; Reed Michael J; Acharya K Ravi; Potter Barry V L
Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
The Biochemical journal 2005;385(Pt 3):715-20.
2005: Acharya K Ravi; Lloyd Matthew D
The advantages and limitations of protein crystal structures.
Trends in pharmacological sciences 2005;26(1):10-4.
2004: Zhang Yingnan; Deshpande Ashlesha; Xie Zhihong; Natesh Ramanathan; Acharya K Ravi; Brew Keith
Roles of active site tryptophans in substrate binding and catalysis by alpha-1,3 galactosyltransferase.
Glycobiology 2004;14(12):1295-302.
2004: Sturrock E D; Natesh R; van Rooyen J M; Acharya K R
Structure of angiotensin I-converting enzyme.
Cellular and molecular life sciences : CMLS 2004;61(21):2677-86.
2004: Errico Michela; Riccioni Teresa; Iyer Shalini; Pisano Claudio; Acharya K Ravi; Persico M Graziella; De Falco Sandro
Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor.
The Journal of biological chemistry 2004;279(42):43929-39.
2004: Turton Kathryn; Natesh Ramanathan; Thiyagarajan Nethaji; Chaddock John A; Acharya K Ravi
Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose.
Glycobiology 2004;14(10):923-9.
2004: Baker Matthew D; Gendlina Inessa; Collins Carleen M; Acharya K Ravi
Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1).
Protein science : a publication of the Protein Society 2004;13(9):2285-90.
2004: Evans Hazel R; Holloway Daniel E; Sutton J Mark; Ayriss Joanne; Shone Clifford C; Acharya K Ravi
C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 8):1502-5.
2004: Natesh Ramanathan; Schwager Sylva L U; Evans Hazel R; Sturrock Edward D; Acharya K Ravi
Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.
Biochemistry 2004;43(27):8718-24.
2004: Baker Matthew D; Acharya K Ravi
Superantigens: structure-function relationships.
International journal of medical microbiology : IJMM 2004;293(7-8):529-37.
2004: Holloway Daniel E; Chavali Gayatri B; Hares Michelle C; Baker Matthew D; Subbarao Gowtham V; Shapiro Robert; Acharya K Ravi
Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41.
Biochemistry 2004;43(5):1230-41.
2004: Papageorgiou Anastassios C; Baker Matthew D; McLeod Julie D; Goda Sayed K; Manzotti Claire N; Sansom David M; Tranter Howard S; Acharya K Ravi
Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition.
The Journal of biological chemistry 2004;279(2):1297-303.
2003: Acharya K Ravi; Sturrock Edward D; Riordan James F; Ehlers Mario R W
Ace revisited: a new target for structure-based drug design.
Nature reviews. Drug discovery 2003;2(11):891-902.
2003: Zhang Yingnan; Swaminathan G Jawahar; Deshpande Ashlesha; Boix Ester; Natesh Ramanathan; Xie Zhihong; Acharya K Ravi; Brew Keith
Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity.
Biochemistry 2003;42(46):13512-21.
2003: Guy Jodie L; Jackson Richard M; Acharya K Ravi; Sturrock Edward D; Hooper Nigel M; Turner Anthony J
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence.
Biochemistry 2003;42(45):13185-92.
2003: Leonidas Demetres D; Chavali Gayatri B; Oikonomakos Nikos G; Chrysina Evangelia D; Kosmopoulou Magda N; Vlassi Metaxia; Frankling Claire; Acharya K Ravi
High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
Protein science : a publication of the Protein Society 2003;12(11):2559-74.
2003: Evans Hazel R; Sutton J Mark; Holloway Daniel E; Ayriss Joanne; Shone Clifford C; Acharya K Ravi
The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD.
The Journal of biological chemistry 2003;278(46):45924-30.
2003: Chavali Gayatri B; Papageorgiou Anastassios C; Olson Karen A; Fett James W; Hu Guo fu; Shapiro Robert; Acharya K Ravi
The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody.
Structure (London, England : 1993) 2003;11(7):875-85.
2003: Swaminathan G Jawahar; Holloway Daniel E; Colvin Richard A; Campanella Gabriele K; Papageorgiou Anastassios C; Luster Andrew D; Acharya K Ravi
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.
Structure (London, England : 1993) 2003;11(5):521-32.
2003: Gordon Kerry; Redelinghuys Pierre; Schwager Sylva L U; Ehlers Mario R W; Papageorgiou Anastassios C; Natesh Ramanathan; Acharya K Ravi; Sturrock Edward D
Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.
The Biochemical journal 2003;371(Pt 2):437-42.
2003: Teufel Daniel P; Kao Richard Y T; Acharya K Ravi; Shapiro Robert
Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2).
Biochemistry 2003;42(6):1451-9.
2003: Natesh Ramanathan; Schwager Sylva L U; Sturrock Edward D; Acharya K Ravi
Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.
Nature 2003;421(6922):551-4.
2003: Baker Matthew D; Acharya K Ravi
Superantigens. Structure, function, and diversity.
Methods in molecular biology (Clifton, N.J.) 2003;214():1-31.
2002: Turton Kathryn; Chaddock John A; Acharya K Ravi
Botulinum and tetanus neurotoxins: structure, function and therapeutic utility.
Trends in biochemical sciences 2002;27(11):552-8.
2002: Mohan C Gopi; Boix Ester; Evans Hazel R; Nikolovski Zoran; Nogués M Victòria; Cuchillo Claudi M; Acharya K Ravi
The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site.
Biochemistry 2002;41(40):12100-6.
2002: Holloway Daniel E; Shapiro Robert; Hares Michelle C; Leonidas Demetres D; Acharya K Ravi
Guest-host crosstalk in an angiogenin-RNase A chimeric protein.
Biochemistry 2002;41(33):10482-9.
2002: Boix Ester; Zhang Yingnan; Swaminathan G Jawahar; Brew Keith; Acharya K Ravi
Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase.
The Journal of biological chemistry 2002;277(31):28310-8.
2002: Iyer Shalini; Acharya K Ravi
Role of placenta growth factor in cardiovascular health.
Trends in cardiovascular medicine 2002;12(3):128-34.
2002: Ackerman Steven J; Liu Li; Kwatia Mark A; Savage Michael P; Leonidas Demetres D; Swaminathan G Jawahar; Acharya K Ravi
Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion.
The Journal of biological chemistry 2002;277(17):14859-68.
2002: Swaminathan G Jawahar; Holloway Daniel E; Veluraja Kasinadar; Acharya K Ravi
Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin.
Biochemistry 2002;41(10):3341-52.
2002: Leonidas Demetres D; Shapiro Robert; Subbarao Gowtham V; Russo Aniello; Acharya K Ravi
Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.
Biochemistry 2002;41(8):2552-62.
2002: Baker Matthew D; Papageorgiou Anastassios C; Titball Richard W; Miller Julie; White Sarah; Lingard Bryan; Lee Jeong Jin; Cavanagh David; Kehoe Michael A; Robinson John H; Acharya K Ravi
Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B.
The Journal of biological chemistry 2002;277(4):2756-62.
2001: Boix E; Swaminathan G J; Zhang Y; Natesh R; Brew K; Acharya K R
Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus.
The Journal of biological chemistry 2001;276(51):48608-14.
2001: Greene L H; Chrysina E D; Irons L I; Papageorgiou A C; Acharya K R; Brew K
Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily.
Protein science : a publication of the Protein Society 2001;10(11):2301-16.
2001: Jardine A M; Leonidas D D; Jenkins J L; Park C; Raines R T; Acharya K R; Shapiro R
Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin.
Biochemistry 2001;40(34):10262-72.
2001: Leonidas D D; Chavali G B; Jardine A M; Li S; Shapiro R; Acharya K R
Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography.
Protein science : a publication of the Protein Society 2001;10(8):1669-76.
2001: Holloway D E; Hares M C; Shapiro R; Subramanian V; Acharya K R
High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins.
Protein expression and purification 2001;22(2):307-17.
2001: Poulas K; Eliopoulos E; Vatzaki E; Navaza J; Kontou M; Oikonomakos N; Acharya K R; Tzartos S J
Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies.
European journal of biochemistry / FEBS 2001;268(13):3685-93.
2001: Swaminathan G J; Weaver A J; Loegering D A; Checkel J L; Leonidas D D; Gleich G J; Acharya K R
Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity.
The Journal of biological chemistry 2001;276(28):26197-203.
2001: Baker M; Gutman D M; Papageorgiou A C; Collins C M; Acharya K R
Structural features of a zinc binding site in the superantigen strepococcal pyrogenic exotoxin A (SpeA1): implications for MHC class II recognition.
Protein science : a publication of the Protein Society 2001;10(6):1268-73.
2001: Leonidas D D; Boix E; Prill R; Suzuki M; Turton R; Minson K; Swaminathan G J; Youle R J; Acharya K R
Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.
The Journal of biological chemistry 2001;276(18):15009-17.
2001: Iyer S; Leonidas D D; Swaminathan G J; Maglione D; Battisti M; Tucci M; Persico M G; Acharya K R
The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
The Journal of biological chemistry 2001;276(15):12153-61.
2000: Chrysina E D; Brew K; Acharya K R
Crystal structures of apo- and holo-bovine alpha-lactalbumin at 2. 2-A resolution reveal an effect of calcium on inter-lobe interactions.
The Journal of biological chemistry 2000;275(47):37021-9.
2000: Papageorgiou A C; Acharya K R
Microbial superantigens: from structure to function.
Trends in microbiology 2000;8(8):369-75.
2000: Kontou M; Leonidas D D; Vatzaki E H; Tsantili P; Mamalaki A; Oikonomakos N G; Acharya K R; Tzartos S J
The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor.
European journal of biochemistry / FEBS 2000;267(8):2389-97.
2000: Papageorgiou A C; Plano L R; Collins C M; Acharya K R
Structural similarities and differences in Staphylococcus aureus exfoliative toxins A and B as revealed by their crystal structures.
Protein science : a publication of the Protein Society 2000;9(3):610-8.
1999: Boix E; Leonidas D D; Nikolovski Z; Nogués M V; Cuchillo C M; Acharya K R
Crystal structure of eosinophil cationic protein at 2.4 A resolution.
Biochemistry 1999;38(51):16794-801.
1999: Swaminathan G J; Leonidas D D; Savage M P; Ackerman S J; Acharya K R
Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution.
Biochemistry 1999;38(42):13837-43.
1999: Leonidas D D; Shapiro R; Irons L I; Russo N; Acharya K R
Toward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor.
Biochemistry 1999;38(32):10287-97.
1999: Greene L H; Grobler J A; Malinovskii V A; Tian J; Acharya K R; Brew K
Stability, activity and flexibility in alpha-lactalbumin.
Protein engineering 1999;12(7):581-7.
1999: Vatzaki E H; Allen S C; Leonidas D D; Trautwein-Fritz K; Stackhouse J; Benner S A; Acharya K R
Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease--the basic surface, at 2.0 A resolution.
European journal of biochemistry / FEBS 1999;260(1):176-82.
1999: Leonidas D D; Shapiro R; Allen S C; Subbarao G V; Veluraja K; Acharya K R
Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.
Journal of molecular biology 1999;285(3):1209-33.
1999: Papageorgiou A C; Collins C M; Gutman D M; Kline J B; O'Brien S M; Tranter H S; Acharya K R
Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors.
The EMBO journal 1999;18(1):9-21.
1998: Leonidas D D; Vatzaki E H; Vorum H; Celis J E; Madsen P; Acharya K R
Structural basis for the recognition of carbohydrates by human galectin-7.
Biochemistry 1998;37(40):13930-40.
1998: Chandra N; Brew K; Acharya K R
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin.
Biochemistry 1998;37(14):4767-72.
1998: Papageorgiou A C; Tranter H S; Acharya K R
Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.
Journal of molecular biology 1998;277(1):61-79.
1997: Papageorgiou A C; Shapiro R; Acharya K R
Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.
The EMBO journal 1997;16(17):5162-77.
1997: Papageorgiou A C; Acharya K R
Superantigens as immunomodulators: recent structural insights.
Structure (London, England : 1993) 1997;5(8):991-6.
1997: Leonidas D D; Shapiro R; Irons L I; Russo N; Acharya K R
Crystal structures of ribonuclease A complexes with 5'-diphosphoadenosine 3'-phosphate and 5'-diphosphoadenosine 2'-phosphate at 1.7 A resolution.
Biochemistry 1997;36(18):5578-88.
1996: Oikonomakos N G; Zographos S E; Tsitsanou K E; Johnson L N; Acharya K R
Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal.
Protein science : a publication of the Protein Society 1996;5(12):2416-28.
1996: Calderone V; Giuffrida M G; Viterbo D; Napolitano L; Fortunato D; Conti A; Acharya K R
Amino acid sequence and crystal structure of buffalo alpha-lactalbumin.
FEBS letters 1996;394(1):91-5.
1996: Papageorgiou A C; Quinn C P; Beer D; Brehm R D; Tranter H S; Bonventre P F; Acharya K R
Crystal structure of a biologically inactive mutant of toxic shock syndrome toxin-1 at 2.5 A resolution.
Protein science : a publication of the Protein Society 1996;5(8):1737-41.
1996: Kontou M; Vatzaki E H; Kokla A; Acharya K R; Oikonomakos N G; Tzartos S J
Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptor.
FEBS letters 1996;389(2):195-8.
1996: Papageorgiou A C; Brehm R D; Leonidas D D; Tranter H S; Acharya K R
The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.
Journal of molecular biology 1996;260(4):553-69.
1996: Pike A C; Brew K; Acharya K R
Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase.
Structure (London, England : 1993) 1996;4(6):691-703.
1996: Russo N; Acharya K R; Vallee B L; Shapiro R
A combined kinetic and modeling study of the catalytic center subsites of human angiogenin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):804-8.
1995: Leonidas D D; Elbert B L; Zhou Z; Leffler H; Ackerman S J; Acharya K R
Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins.
Structure (London, England : 1993) 1995;3(12):1379-93.
1995: Oikonomakos N G; Kontou M; Zographos S E; Watson K A; Johnson L N; Bichard C J; Fleet G W; Acharya K R
N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
Protein science : a publication of the Protein Society 1995;4(12):2469-77.
1995: Oikonomakos N G; Zographos S E; Johnson L N; Papageorgiou A C; Acharya K R
The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies.
Journal of molecular biology 1995;254(5):900-17.
1995: Papageorgiou A C; Acharya K R; Shapiro R; Passalacqua E F; Brehm R D; Tranter H S
Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site.
Structure (London, England : 1993) 1995;3(8):769-79.
1995: Acharya K R; Shapiro R; Riordan J F; Vallee B L
Crystal structure of bovine angiogenin at 1.5-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2949-53.
1994: Allen S C; Acharya K R; Palmer K A; Shapiro R; Vallee B L; Scheraga H A
A comparison of the predicted and X-ray structures of angiogenin. Implications for further studies of model building of homologous proteins.
Journal of protein chemistry 1994;13(7):649-58.
1994: Acharya K R; Stuart D I; Phillips D C; McKenzie H A; Teahan C G
Models of the three-dimensional structures of echidna, horse, and pigeon lysozymes: calcium-binding lysozymes and their relationship with alpha-lactalbumins.
Journal of protein chemistry 1994;13(6):569-84.
1994: Russo N; Shapiro R; Acharya K R; Riordan J F; Vallee B L
Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):2920-4.
1994: Acharya K R; Shapiro R; Allen S C; Riordan J F; Vallee B L
Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):2915-9.
1994: Pike A C; Acharya K R
A structural basis for the interaction of urea with lysozyme.
Protein science : a publication of the Protein Society 1994;3(4):706-10.
1994: Acharya K R; Passalacqua E F; Jones E Y; Harlos K; Stuart D I; Brehm R D; Tranter H S
Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1.
Nature 1994;367(6458):94-7.
1993: Vatzaki E H; Acharya K R; Oikonomakos N G; Tzartos S J
Crystallization and preliminary crystallographic study of an Fab fragment of a pathogenic rat monoclonal antibody against the nicotinic acetylcholine receptor.
Protein science : a publication of the Protein Society 1993;2(10):1770-2.
1993: Passalacqua E F; Brehm R D; Acharya K R; Tranter H S
Crystallization and preliminary X-ray analysis of a microbial superantigen staphylococcal enterotoxin C2.
Journal of molecular biology 1993;233(1):170-2.
1993: Johnson L N; Snape P; Martin J L; Acharya K R; Barford D; Oikonomakos N G
Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b.
Journal of molecular biology 1993;232(1):253-67.
1992: Acharya K R; Subramanian V; Shapiro R; Riordan J F; Vallee B L
Crystallization and preliminary X-ray analysis of human angiogenin.
Journal of molecular biology 1992;228(4):1269-70.
1992: Passalacqua E F; Brehm R D; Acharya K R; Tranter H S
Purification, crystallization and preliminary X-ray analysis of toxic shock syndrome toxin-1 from Staphylococcus aureus.
Journal of molecular biology 1992;228(3):983-6.
1992: Leonidas D D; Oikonomakos N G; Papageorgiou A C; Acharya K R; Barford D; Johnson L N
Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate.
Protein science : a publication of the Protein Society 1992;1(9):1112-22.
1991: Acharya K R; Ren J S; Stuart D I; Phillips D C; Fenna R E
Crystal structure of human alpha-lactalbumin at 1.7 A resolution.
Journal of molecular biology 1991;221(2):571-81.
1990: Acharya K R; Stuart D I; Phillips D C; Scheraga H A
A critical evaluation of the predicted and X-ray structures of alpha-lactalbumin.
Journal of protein chemistry 1990;9(5):549-63.
1989: Acharya K R; Stuart D I; Walker N P; Lewis M; Phillips D C
Refined structure of baboon alpha-lactalbumin at 1.7 A resolution. Comparison with C-type lysozyme.
Journal of molecular biology 1989;208(1):99-127.
1989: Oikonomakos N G; Acharya K R; Melpidou A E; Stuart D I; Johnson L N
The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal.
Archives of biochemistry and biophysics 1989;270(1):62-8.
1988: Barford D; Schwabe J W; Oikonomakos N G; Acharya K R; Hajdu J; Papageorgiou A C; Martin J L; Knott J C; Vasella A; Johnson L N
Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane.
Biochemistry 1988;27(18):6733-41.
1988: Oikonomakos N G; Acharya K R; Stuart D I; Melpidou A E; McLaughlin P J; Johnson L N
Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
European journal of biochemistry / FEBS 1988;173(3):569-78.
1988: Hajdu J; Acharya K R; Stuart D I; Barford D; Johnson L N
Catalysis in enzyme crystals.
Trends in biochemical sciences 1988;13(3):104-9.
1988: Johnson L N; Cheetham J; McLaughlin P J; Acharya K R; Barford D; Phillips D C
Protein-oligosaccharide interactions: lysozyme, phosphorylase, amylases.
Current topics in microbiology and immunology 1988;139():81-134.
1987: Oikonomakos N G; Johnson L N; Acharya K R; Stuart D I; Barford D; Hajdu J; Varvill K M; Melpidou A E; Papageorgiou T; Graves D J
Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
Biochemistry 1987;26(25):8381-9.
1987: Johnson L N; Acharya K R; Stuart D I; Barford D; Oikonomakos N G; Hajdu J; Varvill K M
Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
Biochemical Society transactions 1987;15(5):1001-5.
1987: Phillips D C; Acharya K R; Handoll H H; Stuart D I
From lysozyme to alpha-lactalbumin: protein engineering and evolution.
Biochemical Society transactions 1987;15(4):737-44.
1987: Hajdu J; Acharya K R; Stuart D I; McLaughlin P J; Barford D; Oikonomakos N G; Klein H; Johnson L N
Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
The EMBO journal 1987;6(2):539-46.
1986: Stuart D I; Acharya K R; Walker N P; Smith S G; Lewis M; Phillips D C
Alpha-lactalbumin possesses a novel calcium binding loop.
Nature 1986;324(6092):84-7.
1986: Hajdu J; Acharya K R; Stuart D I; McLaughlin P J; Barford D; Klein H; Johnson L N
Time-resolved structural studies on catalysis in the crystal with glycogen phosphorylase b.
Biochemical Society transactions 1986;14(3):538-41.

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