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Michael Hayden

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TOP 3
Liam R Brunham; Michael R Hayden
Hunting human disease genes: lessons from the past, challenges for the future.
Joanna M Karasinska; Janine K Kruit; Dieter Lütjohann; Piers Ruddle; Sophie Stukas; Cheryl L Wellington; Willeke de Haan; Jianjia Fan; Sonia Franciosi; David H Gutmann; Michael R Hayden
ABCA1 influences neuroinflammation and neuronal death.
Colin J D Ross; Henk Visscher; Amina Barhdadi; Beth Brooks; Andrew M K Brown; Bruce Carleton; Marie-Pierre Dubé; Yassamin Feroz-Zada; Michael R Hayden; Hagit Katzov-Eckert; Michael S Phillips; S Rod Rassekh; Michael J Rieder; Paul C Rogers
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

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All Publications

2013: Liam R Brunham; Michael R Hayden
Hunting human disease genes: lessons from the past, challenges for the future.
Human genetics 2013;132(6):603-17.
2013: Joanna M Karasinska; Janine K Kruit; Dieter Lütjohann; Piers Ruddle; Sophie Stukas; Cheryl L Wellington; Willeke de Haan; Jianjia Fan; Sonia Franciosi; David H Gutmann; Michael R Hayden
ABCA1 influences neuroinflammation and neuronal death.
Neurobiology of disease 2013;54():445-55.
2013: Colin J D Ross; Henk Visscher; Amina Barhdadi; Beth Brooks; Andrew M K Brown; Bruce Carleton; Marie-Pierre Dubé; Yassamin Feroz-Zada; Michael R Hayden; Hagit Katzov-Eckert; Michael S Phillips; S Rod Rassekh; Michael J Rieder; Paul C Rogers
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Nature genetics 2013;45(5):578.
2013: Shahrad Rod Rassekh; Colin J D Ross; Bruce Carleton; Michael R Hayden
Cancer pharmacogenomics in children: research initiatives and progress to date.
Paediatric drugs 2013;15(2):71-81.
2013: A Semaka; Lynda G Balneaves; Michael R Hayden
"Grasping the grey": patient understanding and interpretation of an intermediate allele predictive test result for Huntington disease.
Journal of genetic counseling 2013;22(2):200-17.
2013: Roshni R Singaraja; Suthesh Sivapalaratnam; Ian Tietjen; Mieke D Trip; Cornelia van Duijn; Margaret van Heek; Leonie van Vark-van der Zee; Germaine Verwoert; Michael Winther; Kenny Wong; Albert Hofman; Kees Hovingh; Brian Hubbard; John J Kastelein; Ulf Landmesser; Linus Lin; Jasmin Manz; A David Marais; Jason McEwen; Lyndon J Mitnaul; Meliana Riwanto; Thomas A Roddy; Eric Sijbrands; Steven J Adelman; Bela Asztalos; José Castro-Perez; Heidi L Collins; Geesje Dallinge-Thie; Marie-Pierre Dubé; Michael R Hayden
The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Circulation. Cardiovascular genetics 2013;6(1):54-62.
2013: Liza M Sutton; Fiona B Young; Weining Zhang; Stefanie L Butland; Crystal N Doty; Sonia Franciosi; Vlad Kovalik; Katherine K N Mui; Shaun S Sanders; Mandi E Schmidt; Roshni R Singaraja; Amber L Southwell; Michael R Hayden
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
Human molecular genetics 2013;22(3):452-65.
2013: Alice K Hawkins; Susan Creighton; Michael R Hayden
When access is an issue: exploring barriers to predictive testing for Huntington disease in British Columbia, Canada.
European journal of human genetics : EJHG 2013;21(2):148-53.
2012: Mahmoud A Pouladi; Yuanyun Xie; Weining Zhang; Chiara Zuccato; Jean-Claude Maurel; Christian Néri; Patrick Poucheret; Elsa Brillaud; Elena Cattaneo; Elsa Compte; Paola Conforti; Dagmar Ehrnhoefer; Sonia Franciosi; Rona K Graham; Michael R Hayden
NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease.
Neurobiology of disease 2012;48(3):282-9.
2012: Amber L Southwell; Niels H Skotte; C Frank Bennett; Michael R Hayden
Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases.
Trends in molecular medicine 2012;18(11):634-43.
2012: Jessica Lam; Bruce Carleton; Michael R Hayden; Jeremy N Matlow; Colin J D Ross; Parvaz Madadi
Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: the devil is in the details.
Therapeutic drug monitoring 2012;34(4):378-80.
2012: Liam R Brunham; Michael R Hayden
Medicine. Whole-genome sequencing: the new standard of care?
Science (New York, N.Y.) 2012;336(6085):1112-3.
2012: Liam R Brunham; Bruce Carleton; C Carter; G Kees Hovingh; J W Jukema; J J P Kastelein; Peter J Lansberg; Fudan Miao; Colin J D Ross; A F Stalenhoef; Henk Visscher; L Zhang; Michael R Hayden
Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.
The pharmacogenomics journal 2012;12(3):233-7.
2012: Mahmoud A Pouladi; Lamya S Shihabuddin; Amber L Southwell; Lisa M Stanek; Yuanyun Xie; Weining Zhang; Stefanie Butland; Seng H Cheng; Yu Deng; Sonia Franciosi; Michael R Hayden
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.
Human molecular genetics 2012;21(10):2219-32.
2012: Lauren E Kelly; Bruce Carleton; Michael R Hayden; Parvaz Madadi; Becky Malkin; Michael N Neely; Michael Rieder; Colin Ross; John van den Anker; Gideon Koren
More codeine fatalities after tonsillectomy in North American children.
Pediatrics 2012;129(5):e1343-7.
2012: Valeria Uribe; Kuljeet Vaid; Bibiana K Y Wong; Yuanyun Xie; Weining Zhang; David Howland; Freda D Miller; Yimiao Ou; Yingbin Ouyang; Mahmoud A Pouladi; Niels H Skotte; Amanda Spreeuw; Nagat Bissada; Corey L Cusack; Yu Deng; Mohanish Deshmukh; Dagmar Ehrnhoefer; Konstantin Feinberg; Sonia Franciosi; Graham Kyrenia Rona; Michael R Hayden
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Human molecular genetics 2012;21(9):1954-67.
2012: Fiona B Young; Stefanie L Butland; Shaun S Sanders; Liza M Sutton; Michael R Hayden
Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.
Progress in neurobiology 2012;97(2):220-38.
2012: Henk Visscher; Hesham Al-Saloos; Amina Barhdadi; Andrew M K Brown; Bruce Carleton; Huib N Caron; Marie-Pierre Dubé; Michael R Hayden; leontien c kremer; Michael S Phillips; S Rod Rassekh; Michael J Rieder; Paul C Rogers; Colin J D Ross; George S Sandor; Elvira C van Dalen; H J H van der Pal
Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(13):1422-8.
2012: J Sistonen; M Yazdanpanah; B C Carleton; G Koren; M L A Landsmeer; J W Lee; P Madadi; M Nauta; Colin J D Ross; Michael R Hayden
Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers.
Clinical pharmacology and therapeutics 2012;91(4):692-9.
2012: M E Ketelaar; E M W Hofstra; Michael R Hayden
What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration.
Clinical genetics 2012;81(4):325-33.
2012: Jong-Min Lee; Diane Lucente; Marcy E MacDonald; Karen Marder; Russell L Margolis; Elizabeth McCusker; Patrick J Morrison; Richard H Myers; Jayalakshmi Srinidhi Mysore; Martha Nance; Andrea Novelletto; Eliana Marisa Ramos; Herminia D Rosas; Christopher A Ross; Marie-Helene Saint-Hilaire; Jorge Sequeiros; Ferdinando Squitieri; Oksana Suchowersky; Ronald J Trent; Andrea Zanko; Ruth K Abramson; Tetsuo Ashizawa; Carmen Ayuso; Stefano Di Donato; Samuel Frank; Marina Frontali; Tammy Gillis; Estrella Gomez-Tortosa; Annamaria Griguoli; Madaline B Harrison; Michael R Hayden; Steven M Hersch; Randi Jones; James F Gusella
Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.
American journal of human genetics 2012;90(3):434-44.
2012: J-M Lee; D Lucente; Marcy E MacDonald; K Marder; Russell L Margolis; E McCusker; P Morrison; R H Myers; J S Mysore; M Nance; A Novelletto; S Orobello; Jane S Paulsen; E M Ramos; H D Rosas; Christopher A Ross; M H Saint-Hilaire; J Sequeiros; F Squitieri; O Suchowersky; R J A Trent; S C Warby; A Zanko; R K Abramson; T Ashizawa; C Ayuso; S Di Donato; S Frank; M Frontali; T Gillis; E Gomez-Tortosa; J F Gusella; M B Harrison; Michael R Hayden; Steven M Hersch; R Jones; G B Landwehrmeyer; J-H Lee
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
Neurology 2012;78(10):690-5.
2012: Nadeeja Wijesekara; Lin-hua Zhang; Thomas Abraham; Alpana Bhattacharjee; Martin H Kang; C Bruce Verchere; Garth L Warnock; Michael R Hayden
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.
Diabetes 2012;61(3):653-8.
2012: Janine K Kruit; Dieter Lütjohann; Renmei Tang; Tim Vanmierlo; C Bruce Verchere; Cheryl L Wellington; Clara Westwell-Roper; Nadeeja Wijesekara; Alpana Bhattacharjee; Liam R Brunham; Willeke de Haan; James D Johnson; Michael R Hayden
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.
Diabetes 2012;61(3):659-64.
2012: Yvonne Bombard; Joan L Bottorff; Susan Creighton; Jan M Friedman; Michael R Hayden; JoAnne Palin; Gerry Veenstra
Beyond the patient: the broader impact of genetic discrimination among individuals at risk of Huntington disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2012;159B(2):217-26.
2012: Ian Tietjen; Elden Chan; G Kees Hovingh; John J P Kastelein; Annick Legendre; Maryanne Mattice; Jason McEwen; Christopher C Radomski; Roshni Singaraja; Michael R Hayden
Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT.
Biochimica et biophysica acta 2012;1821(3):416-24.
2012: Elaine Waldron-Roby; XiaoFang Wang; Erin Watkin; Deborah Swing; Lino Tessarollo; nicolas arbez; WENZHEN DUAN; Graham Kyrenia Rona; Michael R Hayden; Zhipeng Hou; Mali Jiang; Susumu Mori; Mikhail V Pletnikov; TAMARA RATOVITSKI; Christopher A Ross
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(1):183-93.
2012: Ian Tietjen; Amina Barhdadi; Elden Chan; Marie-Pierre Dubé; Patrick L Franchini; G Kees Hovingh; John J P Kastelein; Annick Legendre; Maryanne Mattice; Jason McEwen; Christopher C Radomski; Roshni R Singaraja; Michael R Hayden
Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol.
PloS one 2012;7(8):e37437.
2012: Fiona B Young; Weining Zhang; Nagat Bissada; Yu Deng; Sonia Franciosi; Kun Huang; Chris Kay; Shaun Sanders; Roshni R Singaraja; Amanda Spreeuw; Natalie C M Tam; Michael R Hayden
Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.
PloS one 2012;7(5):e36315.
2012: Yigal Paul Goldberg; Charles Jay Cohen; Robin Sherrington; Henry Verschoof; Nicola Price; Clint E Young; Simon Neil Pimstone; Mieke H Lamers; Rostam Namdari; Conrad Winters; James Price; Michael R Hayden
Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker.
Pain 2012;153(1):80-5.
2012: Sonia Franciosi; Michael R Hayden; Austin Hill; James G McLarnon; Jae K Ryu; Yaein Shim; Colum Connolly; Blair R Leavitt
Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease.
Neurobiology of disease 2012;45(1):438-49.
2012: Jessica Lam; Bruce C Carleton; Catherine Ciszkowski; Marieke Nauta; Parvaz Madadi; Lauren Kelly; Michael R Hayden; Marieke L A Landsmeer; Gideon Koren
Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia.
The Journal of pediatrics 2012;160(1):33-7.e2.
2012: Y Bombard; A Semaka; Michael R Hayden
Adoption and the communication of genetic risk: experiences in Huntington disease.
Clinical genetics 2012;81(1):64-9.
2011: Graham Kyrenia Rona; Dagmar Ehrnhoefer; Michael R Hayden
Caspase-6 and neurodegeneration.
Trends in neurosciences 2011;34(12):646-56.
2011: Janine K Kruit; Peter E Light; Patrick E MacDonald; Brad J Marsh; Garry P Morgan; Gavin J Searle; Renmei Tang; C Bruce Verchere; Nadeeja Wijesekara; Alpana Bhattacharjee; Liam R Brunham; Adam J Costin; Xiao-Qing Dai; Jocelyn E Manning Fox; James D Johnson; Michael R Hayden
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.
Diabetes 2011;60(12):3186-96.
2011: Jeffrey B Carroll; Crystal N Doty; Susan M Freier; Sarah Greenlee; Gene Hung; Niels Skotte; Amber L Southwell; Simon Warby; C Frank Bennett; Michael R Hayden
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(12):2178-85.
2011: Dagmar Ehrnhoefer; Bibiana K Y Wong; Michael R Hayden
Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.
Nature reviews. Drug discovery 2011;10(11):853-67.
2011: Roshni R Singaraja; Kuljeet Vaid; Junmei Wan; Fiona B Young; Nagat Bissada; Nicholas G Davis; Crystal Doty; Renaldo C Drisdel; Sonia Franciosi; William N Green; R Mark Henkelman; Rochelle Hines; Kun Huang; Jason P Lerch; Austen J Milnerwood; Lynn A Raymond; Shaun S Sanders; Michael R Hayden
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
Human molecular genetics 2011;20(20):3899-909.
2011: Alice K Hawkins; Anita Ho; Michael R Hayden
Lessons from predictive testing for Huntington disease: 25 years on.
Journal of medical genetics 2011;48(10):649-50.
2011: Joanna M Karasinska; Michael R Hayden
Cholesterol metabolism in Huntington disease.
Nature reviews. Neurology 2011;7(10):561-72.
2011: Dagmar Ehrnhoefer; Liza Sutton; Michael R Hayden
Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2011;17(5):475-92.
2011: Yann Joly; Georgia Koutrikas; Emma Ramos-Paque; Ma'n Zawati; Jennifer Gardy; Michael R Hayden; Bruce Carleton
Diagnostic testing for vaccinomics: is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe.
Omics : a journal of integrative biology 2011;15(9):597-605.
2011: Kun Huang; Rujun Kang; Lili Liu; Shaun S Sanders; Roshni R Singaraja; Liza Sutton; Junmei Wan; Fiona B Young; Jeffrey B Carroll; Nicholas G Davis; Alaa El-Husseini; Michael R Hayden
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Human molecular genetics 2011;20(17):3356-65.
2011: Henk Visscher; Ursula Amstutz; Michael R Hayden; Colin J Ross; Johanna Sistonen; Bruce C Carleton
Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.
Journal of cardiovascular pharmacology 2011;58(3):228-39.
2011: Sondra VanderVaart; Howard Berger; Bruce Carleton; Saskia N de Wildt; Violette M G J Gijsen; Michael R Hayden; Parvaz Madadi; Ilan Matok; Colin J D Ross; Johanna Sistonen; Anna Taddio; Gideon Koren
CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study.
Therapeutic drug monitoring 2011;33(4):425-32.
2011: Jeffrey B Carroll; Jason P Lerch; Sonia Franciosi; Amanda Spreeuw; Nagat Bissada; R Mark Henkelman; Michael R Hayden
Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease.
Neurobiology of disease 2011;43(1):257-65.
2011: L R Brunham; P L Franchini; G K Hovingh; J J P Kastelein; R R Singaraja; I Tietjen; C Radomski; M Mattice; A Legendre; A E Bochem; Michael R Hayden
Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans.
Clinical genetics 2011;79(6):575-81.
2011: Simon C Warby; Henk Visscher; Jennifer A Collins; Crystal N Doty; Catherine Carter; Stefanie L Butland; Anna R Hayden; Ichiro Kanazawa; Colin J Ross; Michael R Hayden
HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.
European journal of human genetics : EJHG 2011;19(5):561-6.
2011: Wenjun Song; Jin Chen; Alejandra Petrilli; Geraldine Liot; Eva Klinglmayr; Yue Zhou; Patrick Poquiz; Jonathan Tjong; Mahmoud A Pouladi; Michael R Hayden; Eliezer Masliah; Mark Ellisman; Isabelle Rouiller; Robert Schwarzenbacher; Blaise Bossy; Guy Perkins; Ella Bossy-Wetzel
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
Nature medicine 2011;17(3):377-82.
2011: Alice K Hawkins; Michael R Hayden
A grand challenge: providing benefits of clinical genetics to those in need.
Genetics in medicine : official journal of the American College of Medical Genetics 2011;13(3):197-200.
2011: Jessica M Simpson; Joana Gil-Mohapel; Mahmoud A Pouladi; Mohamed Ghilan; Yuanyun Xie; Michael R Hayden; Brian R Christie
Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease.
Neurobiology of disease 2011;41(2):249-60.
2011: Dagmar Ehrnhoefer; Li-Ping Cao; Edie Dullaghan; Safia Ladha; Yen T N Nguyen; Jane Savill; Niels H Skotte; Michael R Hayden
A quantitative method for the specific assessment of caspase-6 activity in cell culture.
PloS one 2011;6(11):e27680.
2011: Yinyuan Ding; Michael R Hayden; Wei Huang; Colin J D Ross; Yin Tang; Yuhui Wang; Ling Zhang; Lu Bai; George Liu
Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL.
PloS one 2011;6(9):e25620.
2011: Jeffrey B Carroll; Yu Deng; Dagmar Ehrnhoefer; Graham Kyrenia Rona; R Mark Henkelman; Jason P Lerch; Amber L Southwell; Wei-Ning Zhang; Nagat Bissada; Li-Ping Cao; Michael R Hayden
Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.
Molecular neurodegeneration 2011;6():59.
2011: Parvaz Madadi; Yann Joly; Denise Avard; David C Chitayat; M Anne Smith; Colin J D Ross; Bruce Carleton; Michael R Hayden; Gideon Koren
The communication of pharmacogenetic research results: participants weigh in on their informational needs in a pilot study.
Journal of population therapeutics and clinical pharmacology = Journal de la thérapeutique des populations et de la pharamcologie clinique 2011;18():e152-5.
2011: Colin J D Ross; Henk Visscher; S Rod Rassekh; Lucila I Castro-Pastrana; Evan Shereck; Bruce Carleton; Michael R Hayden
Pharmacogenomics of serious adverse drug reactions in pediatric oncology.
Journal of population therapeutics and clinical pharmacology = Journal de la thérapeutique des populations et de la pharamcologie clinique 2011;18():e134-51.
2011: Lucila I Castro-Pastrana; Reza Ghannadan; Michael J Rieder; Erin Dahlke; Michael R Hayden; Bruce Carleton
Cutaneous adverse drug reactions in children: an analysis of reports from the Canadian Pharmacogenomics Network for Drug Safety (CPNDS).
Journal of population therapeutics and clinical pharmacology = Journal de la thérapeutique des populations et de la pharamcologie clinique 2011;18():e106-20.
2011: Dan Ye; Ying Zhao; Reeni B Hildebrand; Roshni R Singaraja; Michael R Hayden; Theo Van berkel; Miranda van Eck
The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice.
The American journal of pathology 2011;178(1):413-22.
2011: Yvonne Bombard; JoAnne Palin; Jan M Friedman; Gerry Veenstra; Susan Creighton; Jane S Paulsen; Joan L Bottorff; Michael R Hayden
Factors associated with experiences of genetic discrimination among individuals at risk for Huntington disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(1):19-27.
2010: P Madadi; Y Joly; D Avard; D C Chitayat; M A Smith; Colin J D Ross; B C Carleton; Michael R Hayden; Gideon Koren
Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits.
Clinical pharmacology and therapeutics 2010;88(6):792-5.
2010: Graham Kyrenia Rona; Yu Deng; Jeffery Carroll; Kuljeet Vaid; Catherine Cowan; Mahmoud A Pouladi; Martina Metzler; Nagat Bissada; Lili Wang; Richard L M Faull; Michelle Gray; X William Yang; Lynn A Raymond; Michael R Hayden
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(45):15019-29.
2010: A Sturrock; C Laule; J Decolongon; R Dar Santos; A J Coleman; S Creighton; N Bechtel; R Reilmann; Michael R Hayden; S J Tabrizi; A L Mackay; Blair R Leavitt
Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease.
Neurology 2010;75(19):1702-10.
2010: Yuxiang Xie; Michael R Hayden; Baoji Xu
BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(44):14708-18.
2010: Martina Metzler; Lu Gan; Gelareh Mazarei; Graham Kyrenia Rona; Lili Liu; Nagat Bissada; Ge Lu; Blair R Leavitt; Michael R Hayden
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14318-29.
2010: Parvaz Madadi; Doris Hildebrandt; Inna Y Gong; Ute I Schwarz; Catherine Ciszkowski; Colin J D Ross; Johanna Sistonen; Bruce C Carleton; Michael R Hayden; Albert E Lauwers; Gideon Koren
Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.
Pediatrics 2010;126(4):e986-9.
2010: Kun Huang; Martin H Kang; Caitlin Askew; Rujun Kang; Shaun S Sanders; Junmei Wan; Nicholas G Davis; Michael R Hayden
Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease.
Neurobiology of disease 2010;40(1):207-15.
2010: Tenneille T Loo; Colin J D Ross; Johanna Sistonen; Henk Visscher; Parvaz Madadi; Gideon Koren; Michael R Hayden; Bruce Carleton
Pharmacogenomics and active surveillance for serious adverse drug reactions in children.
Pharmacogenomics 2010;11(9):1269-85.
2010: Janet K Williams; Cheryl Erwin; Andrew R Juhl; Michelle Mengeling; Yvonne Bombard; Michael R Hayden; Kimberly Quaid; Ira Shoulson; Sandra Taylor; Jane S Paulsen
In their own words: reports of stigma and genetic discrimination by people at risk for Huntington disease in the International RESPOND-HD study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(6):1150-9.
2010: Marta Valenza; Valerio Leoni; Joanna M Karasinska; Lara Petricca; Jianjia Fan; Jeffrey Carroll; Mahmoud A Pouladi; Elisa Fossale; Huu-Phuc Nguyen; Olaf Riess; Marcy E MacDonald; Cheryl L Wellington; Stefano DiDonato; Michael R Hayden; Elena Cattaneo
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(32):10844-50.
2010: Victor Acuna Alonzo; Teresa Flores-Dorantes; Janine K Kruit; Teresa Villarreal-Molina; Olimpia Arellano-Campos; Tábita Hünemeier; Andrés Moreno-Estrada; Ma Guadalupe Ortiz-López; Hugo Villamil-Ramírez; Paola León-Mimila; Marisela Villalobos-Comparan; Leonor Jacobo-Albavera; Salvador Ramírez-Jiménez; Martin Sikora; Lin-Hua Zhang; Terry D Pape; Ma de Angeles Granados-Silvestre; Isela Montufar-Robles; Ana M Tito-Alvarez; Camilo Zurita-Salinas; José Bustos-Arriaga; Leticia Cedillo-Barrón; Celta Gómez-Trejo; Rodrigo Barquera-Lozano; Joao P Vieira-Filho; Julio Granados; Sandra Romero-Hidalgo; Adriana Huertas-Vázquez; Antonio González-Martín; Amaya Gorostiza; Sandro L Bonatto; Maricela Rodríguez-Cruz; Li Wang; Teresa Tusié-Luna; Carlos A Aguilar-Salinas; Ruben Lisker; Regina S Moises; Marta Menjivar; Francisco M Salzano; William C Knowler; M Cátira Bortolini; Michael R Hayden; Leslie J Baier; Samuel Canizales-Quinteros
A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans.
Human molecular genetics 2010;19(14):2877-85.
2010: Colin J D Ross; Henk Visscher; Johanna Sistonen; Liam R Brunham; Kusala Pussegoda; Tenneille T Loo; Michael J Rieder; Gideon Koren; Bruce Carleton; Michael R Hayden
The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.
Thyroid : official journal of the American Thyroid Association 2010;20(7):681-7.
2010: Cheryl Erwin; Janet K Williams; Andrew R Juhl; Michelle Mengeling; James A Mills; Yvonne Bombard; Michael R Hayden; Kimberly Quaid; Ira Shoulson; Sandra Taylor; Jane S Paulsen
Perception, experience, and response to genetic discrimination in Huntington disease: the international RESPOND-HD study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(5):1081-93.
2010: Sander I van Leuven; Diederik F van Wijk; Oscar L Volger; Jean-Paul P M de Vries; Chris M van der Loos; Dominique V P de Kleijn; Anton J G Horrevoets; Paul P Tak; Allard C van der Wal; Onno J de Boer; Gerard Pasterkamp; Michael R Hayden; John J P Kastelein; Erik S G Stroes
Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis.
Atherosclerosis 2010;211(1):231-6.
2010: Janine K Kruit; Liam R Brunham; C Bruce Verchere; Michael R Hayden
HDL and LDL cholesterol significantly influence beta-cell function in type 2 diabetes mellitus.
Current opinion in lipidology 2010;21(3):178-85.
2010: Janine K Kruit; P H C Kremer; L Dai; R Tang; P Ruddle; W de Haan; Liam R Brunham; C Bruce Verchere; Michael R Hayden
Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice.
Diabetologia 2010;53(6):1110-9.
2010: Gunilla Olivecrona; Ewa Ehrenborg; Henrik Semb; Elena Makoveichuk; Anna Lindberg; Michael R Hayden; Peter Gin; Brandon S J Davies; Michael M Weinstein; Loren G Fong; Anne P Beigneux; Stephen G Young; Thomas Olivecrona; Olle Hernell
Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia.
Journal of lipid research 2010;51(6):1535-45.
2010: Soonkyu Chung; Jenelle M Timmins; MyNgan Duong; Chiara Degirolamo; Shunxing Rong; Janet K Sawyer; Roshni R Singaraja; Michael R Hayden; Nobuyo Maeda; Lawrence L Rudel; Gregory S Shelness; John S Parks
Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
The Journal of biological chemistry 2010;285(16):12197-209.
2010: Mahmoud A Pouladi; Yuanyun Xie; Niels Henning Skotte; Dagmar Ehrnhoefer; Graham Kyrenia Rona; Jeong Eun Kim; Nagat Bissada; X William Yang; Paolo Paganetti; Robert M Friedlander; Blair R Leavitt; Michael R Hayden
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
Human molecular genetics 2010;19(8):1528-38.
2010: Kristina Becanovic; Mahmoud A Pouladi; Raymond S Lim; Alexandre Kuhn; Paul Pavlidis; Ruth Luthi-Carter; Michael R Hayden; Blair R Leavitt
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.
Human molecular genetics 2010;19(8):1438-52.
2010: Menno Vergeer; Liam R Brunham; Joris Koetsveld; Janine K Kruit; C Bruce Verchere; John J P Kastelein; Michael R Hayden; Erik S G Stroes
Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction.
Diabetes care 2010;33(4):869-74.
2010: Douglas R Langbehn; Michael R Hayden; Jane S Paulsen
CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(2):397-408.
2010: Martin H Kang; Roshni R Singaraja; Michael R Hayden
Adenosine-triphosphate-binding cassette transporter-1 trafficking and function.
Trends in cardiovascular medicine 2010;20(2):41-9.
2010: Liam R Brunham; Janine K Kruit; Michael R Hayden; C Bruce Verchere
Cholesterol in beta-cell dysfunction: the emerging connection between HDL cholesterol and type 2 diabetes.
Current diabetes reports 2010;10(1):55-60.
2010: Austen J Milnerwood; Clare M Gladding; Mahmoud A Pouladi; Alexandra M Kaufman; Rochelle M Hines; Jamie D Boyd; Rebecca W Y Ko; Oana C Vasuta; Graham Kyrenia Rona; Michael R Hayden; Timothy H Murphy; Lynn A Raymond
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.
Neuron 2010;65(2):178-90.
2010: A Semaka; J A Collins; Michael R Hayden
Unstable familial transmissions of Huntington disease alleles with 27-35 CAG repeats (intermediate alleles).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(1):314-20.
2010: Yi-Lei Ding; Yu-Hui Wang; Wei Huang; George Liu; Colin Ross; Michael R Hayden; Jin-Kui Yang
Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia.
Experimental biology and medicine (Maywood, N.J.) 2010;235(1):40-6.
2010: Melissa B Glier; Pavlos Pissios; Sandra L Babich; Marcia L E MacDonald; Michael R Hayden; Eleftheria Maratos-Flier; William T Gibson
The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone.
Peptides 2010;31(1):123-9.
2009: Leslie Michels Thompson; Charity T Aiken; Linda S Kaltenbach; Namita Agrawal; Katalin Illes; Ali Khoshnan; Marta Martinez-Vincente; Montserrat Arrasate; Jacqueline Gire O'Rourke; Hasan Khashwji; Tamas Lukacsovich; Ya-Zhen Zhu; Alice L Lau; Ashish Massey; Michael R Hayden; Scott O Zeitlin; Steven Finkbeiner; Kim N Green; Frank M LaFerla; Gillian P Bates; Lan Huang; Paul H Patterson; Donald C Lo; Ana Maria Cuervo; J Lawrence Marsh; Joan S Steffan
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
The Journal of cell biology 2009;187(7):1083-99.
2009: Simon C Warby; Henk Visscher; Stefanie Butland; Christopher E Pearson; Michael R Hayden
Response to Falush: a role for cis-element polymorphisms in HD.
American journal of human genetics 2009;85(6):942-5.
2009: Shu-ichi Okamoto; Mahmoud A Pouladi; Maria Talantova; Dongdong Yao; Peng Xia; Dagmar Ehrnhoefer; Rameez Zaidi; Arjay Clemente; Marcus Kaul; Graham Kyrenia Rona; Dongxian Zhang; H-S Vincent Chen; Gang Tong; Michael R Hayden; Stuart A Lipton
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.
Nature medicine 2009;15(12):1407-13.
2009: Colin J D Ross; Hagit Katzov-Eckert; Marie-Pierre Dubé; Beth Brooks; S Rod Rassekh; Amina Barhdadi; Yassamin Feroz-Zada; Henk Visscher; Andrew M K Brown; Michael J Rieder; Paul C Rogers; Michael S Phillips; Bruce Carleton; Michael R Hayden
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
Nature genetics 2009;41(12):1345-9.
2009: Marcia L E MacDonald; Nagat Bissada; Bruce A Vallance; Michael R Hayden
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis.
Biochimica et biophysica acta 2009;1791(12):1166-72.
2009: Henk Visscher; Colin J D Ross; Marie-Pierre Dubé; A M K Brown; M S Phillips; Bruce Carleton; Michael R Hayden
Application of principal component analysis to pharmacogenomic studies in Canada.
The pharmacogenomics journal 2009;9(6):362-72.
2009: Jing Fan; Catherine M Cowan; Lily Y J Zhang; Michael R Hayden; Lynn A Raymond
Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(35):10928-38.
2009: Xunde Xian; Yu Ding; Ling Zhang; Yanan Wang; Michael A McNutt; Colin Ross; Michael R Hayden; Xuming Deng; George Liu
Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice.
Biochemical and biophysical research communications 2009;385(4):563-9.
2009: Bruce Carleton; Rl Poole; Ma Smith; Js Leeder; R Ghannadan; Cjd Ross; Ms Phillips; Michael R Hayden
Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Pharmacoepidemiology and drug safety 2009;18(8):713-21.
2009: Kun Huang; Shaun Sanders; Roshni R Singaraja; Paul Orban; Tony Cijsouw; Pamela Arstikaitis; Anat Yanai; Michael R Hayden; Alaa El-Husseini
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2605-15.
2009: Roshni R Singaraja; Martin H Kang; Kuljeet Vaid; Shaun S Sanders; Gonzalo L Vilas; Pamela Arstikaitis; Jonathan Coutinho; Renaldo C Drisdel; Alaa El Din El-Husseini; William N Green; Luc Berthiaume; Michael R Hayden
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.
Circulation research 2009;105(2):138-47.
2009: Garabet Yeretssian; Karine Doiron; Wei Shao; Blair R Leavitt; Michael R Hayden; Donald W Nicholson; Maya Saleh
Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):9016-20.
2009: Stefan F C Vaessen; Geesje M Dallinga-Thie; Colin J D Ross; L J Splint; L W Castellani; P C N Rensen; Michael R Hayden; Frank G Schaap; Jan Albert Kuivenhoven
Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.
Journal of lipid research 2009;50(5):880-4.
2009: TAMARA RATOVITSKI; Marjan Gucek; Haibing Jiang; Ekaterine Chighladze; Elaine Waldron; James D'Ambola; Zhipeng Hou; Yideng Liang; Michelle A Poirier; RICKY HIRSCHHORN; Graham Kyrenia Rona; Michael R Hayden; Robert N Cole; Christopher A Ross
Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.
The Journal of biological chemistry 2009;284(16):10855-67.
2009: Xunde Xian; Tingting Liu; Jia Yu; Yuhui Wang; Yifei Miao; Jianjun Zhang; Yan Yu; Colin Ross; Joanna M Karasinska; Michael R Hayden; George Liu; Dehua Chui
Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(14):4681-5.
2009: Mahmoud A Pouladi; Graham Kyrenia Rona; Joanna M Karasinska; Yuanyun Xie; Rachelle Dar Santos; Asa Petersén; Michael R Hayden
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.
Brain : a journal of neurology 2009;132(Pt 4):919-32.
2009: Liam R Brunham; Roshni R Singaraja; MyNgan Duong; Jenelle M Timmins; Catherine Fievet; Nagat Bissada; Martin H Kang; Amrit Samra; Jean-Charles Fruchart; Bruce McManus; Bart Staels; John S Parks; Michael R Hayden
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):548-54.
2009: Joanna M Karasinska; Franz Rinninger; Dieter Lütjohann; Piers Ruddle; Sonia Franciosi; Janine K Kruit; Roshni R Singaraja; Veronica Hirsch-Reinshagen; Jianjia Fan; Liam R Brunham; Nagat Bissada; Rajasekhar Ramakrishnan; Cheryl L Wellington; John S Parks; Michael R Hayden
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3579-89.
2009: Dagmar Ehrnhoefer; Stefanie L Butland; Mahmoud A Pouladi; Michael R Hayden
Mouse models of Huntington disease: variations on a theme.
Disease models & mechanisms 2009;2(3-4):123-9.
2009: Simon C Warby; Alexandre Montpetit; Anna R Hayden; Jeffrey B Carroll; Stefanie L Butland; Henk Visscher; Jennifer A Collins; Alicia Semaka; Thomas J Hudson; Michael R Hayden
CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.
American journal of human genetics 2009;84(3):351-66.
2009: Marcia L E MacDonald; Miranda van Eck; Reeni B Hildebrand; Brian W C Wong; Nagat Bissada; Piers Ruddle; Anatol Kontush; Hala Hussein; Mahmoud A Pouladi; M John Chapman; Catherine Fievet; Theo Van berkel; Bart Staels; Bruce M McManus; Michael R Hayden
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(3):341-7.
2009: Yu Wang; L Sternfeld; F Yang; J A Rodriguez; Christopher A Ross; Michael R Hayden; F Carriere; Gang Liu; W Hofer; I Schulz
Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells.
Gut 2009;58(3):422-30.
2009: Prasad R Joshi; Nan-Ping Wu; Veronique Andre; Damian M Cummings; Carlos Cepeda; John A Joyce; Jeffrey B Carroll; Blair R Leavitt; Michael R Hayden; Michael S Levine; Nigel S Bamford
Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(8):2414-27.
2009: Graham Kyrenia Rona; Mahmoud A Pouladi; Prasad Joshi; Ge Lu; Yu Deng; Nan-Ping Wu; Bryan E Figueroa; Martina Metzler; Veronique Andre; Elizabeth J Slow; Lynn Raymond; Robert Friedlander; Michael S Levine; Blair R Leavitt; Michael R Hayden
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2193-204.
2009: Iván Bartha; Tamás Dinya; Ildikó Seres; György Paragh; Colin Ross; Michael R Hayden; Sándor Biró; György Vargha
Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation.
Clinica chimica acta; international journal of clinical chemistry 2009;400(1-2):137-8.
2009: Simon Warby; Crystal N Doty; Graham Kyrenia Rona; Jonathan Shively; Roshni R Singaraja; Michael R Hayden
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
Molecular and cellular neurosciences 2009;40(2):121-7.
2009: Yvonne Bombard; Gerry Veenstra; Jan M Friedman; Susan Creighton; Lauren Currie; Jane S Paulsen; Joan L Bottorff; Michael R Hayden
Perceptions of genetic discrimination among people at risk for Huntington's disease: a cross sectional survey.
BMJ (Clinical research ed.) 2009;338():b2175.
2009: E Wong; B C Carleton; D F B Wright; M A Smith; L Verbeek; C A Hildebrand; P Stannard; regis vaillancourt; P Elliot-Miller; C J D Ross; Michael R Hayden
Genotypic Approaches to Therapy in Children (GATC): using information technology to improve drug safety.
Studies in health technology and informatics 2009;143():209-14.
2009: Michael R Hayden; Blair R Leavitt; Uma Yasothan; Peter Kirkpatrick
Tetrabenazine.
Nature reviews. Drug discovery 2009;8(1):17-8.
2009: F Yang; Y Wang; L Sternfeld; J A Rodriguez; Christopher A Ross; Michael R Hayden; F Carriere; G Liu; I Schulz
The role of free fatty acids, pancreatic lipase and Ca+ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice.
Acta physiologica (Oxford, England) 2009;195(1):13-28.
2009: P Madadi; C J D Ross; Michael R Hayden; B C Carleton; A Gaedigk; J S Leeder; G Koren
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Clinical pharmacology and therapeutics 2009;85(1):31-5.
2008: Erik S G Stroes; Melchior C Nierman; Janneke J Meulenberg; Remco Franssen; Jaap Twisk; C Pieter Henny; Mario M Maas; Aeilko H Zwinderman; Colin Ross; Eleonora Aronica; Katherine A High; Marcel M Levi; Michael R Hayden; John J Kastelein; Jan Albert Kuivenhoven
Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2303-4.
2008: Catherine M Cowan; Mannie M Y Fan; Jing Fan; Jacqueline Shehadeh; Lily Y J Zhang; Graham Kyrenia Rona; Michael R Hayden; Lynn A Raymond
Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12725-35.
2008: Liam R Brunham; John J P Kastelein; Michael R Hayden
ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease.
JAMA : the journal of the American Medical Association 2008;300(17):1997-8; author reply 1998.
2008: Alicia Semaka; Simon Warby; Blair R Leavitt; Michael R Hayden
Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats.
Movement disorders : official journal of the Movement Disorder Society 2008;23(12):1794-5; author reply 1793.
2008: Chuan-En Wang; Suzanne Tydlacka; Adam L Orr; Shang-Hsun Yang; Graham Kyrenia Rona; Michael R Hayden; Shihua Li; Anthony W S Chan; Xiao-Jiang Li
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
Human molecular genetics 2008;17(17):2738-51.
2008: Maria Björkqvist; Edward J Wild; Jenny Thiele; Aurelio Silvestroni; Ralph Andre; Nayana Lahiri; Elsa Raibon; Richard V Lee; Caroline L Benn; Denis Soulet; Anna Magnusson; Ben Woodman; Christian Landles; Mahmoud A Pouladi; Michael R Hayden; Azadeh Khalili-Shirazi; Mark W Lowdell; Patrik Brundin; Gillian P Bates; Blair R Leavitt; Thomas Möller; Sarah J Tabrizi
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
The Journal of experimental medicine 2008;205(8):1869-77.
2008: Simon Warby; Crystal N Doty; Graham Kyrenia Rona; Jeffrey B Carroll; Yu-Zhou Yang; Roshni R Singaraja; Christopher M Overall; Michael R Hayden
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Human molecular genetics 2008;17(15):2390-404.
2008: Jane S Paulsen; Douglas R Langbehn; Julie C Stout; Elizabeth H Aylward; Christopher A Ross; Martha Nance; Mark Guttman; S Johnson; Marcy E MacDonald; Leigh J Beglinger; Kevin Duff; Elise Kayson; K Biglan; Ira Shoulson; David Oakes; Michael R Hayden
Detection of Huntington's disease decades before diagnosis: the Predict-HD study.
Journal of neurology, neurosurgery, and psychiatry 2008;79(8):874-80.
2008: Hua Zhang; Qin Li; Graham Kyrenia Rona; Elizabeth J Slow; Michael R Hayden; Ilya Bezprozvanny
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
Neurobiology of disease 2008;31(1):80-8.
2008: Jason P Lerch; Jeffrey B Carroll; Adrienne Dorr; Shoshana Spring; Alan C Evans; Michael R Hayden; John G Sled; R Mark Henkelman
Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease.
NeuroImage 2008;41(2):243-51.
2008: Elizabeth Penziner; Janet K Williams; Cheryl Erwin; Yvonne Bombard; Anne Wallis; Leigh J Beglinger; Michael R Hayden; Jane S Paulsen
Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147(3):320-5.
2008: Yvonne Bombard; Elizabeth Penziner; Oksana Suchowersky; Mark Guttman; Jane S Paulsen; Joan L Bottorff; Michael R Hayden
Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease.
European journal of human genetics : EJHG 2008;16(3):279-89.
2008: Liam R Brunham; Janine K Kruit; C Bruce Verchere; Michael R Hayden
Cholesterol in islet dysfunction and type 2 diabetes.
The Journal of clinical investigation 2008;118(2):403-8.
2008: Xiaohong Zhang; Rong Qi; Xunde Xian; Fei Yang; Michael Blackstein; Xuming Deng; Jianglin Fan; Colin Ross; Joanna Karasinska; Michael R Hayden; George Liu
Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.
Circulation research 2008;102(2):250-6.
2008: Mannie M Y Fan; Hong Zhang; Michael R Hayden; Steven Pelech; Lynn A Raymond
Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.
Journal of neurochemistry 2008;104(3):790-805.
2008: Marcia L E MacDonald; Roshni R Singaraja; Nagat Bissada; Piers Ruddle; Russell Watts; Joanna M Karasinska; William T Gibson; Catherine Fievet; Jean E Vance; Bart Staels; Michael R Hayden
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.
Journal of lipid research 2008;49(1):217-29.
2008: Jason P Lerch; Jeffrey B Carroll; Shoshana Spring; Lisa N Bertram; Claudia Schwab; Michael R Hayden; R Mark Henkelman
Automated deformation analysis in the YAC128 Huntington disease mouse model.
NeuroImage 2008;39(1):32-9.
2007: Herman B Fernandes; Kenneth G Baimbridge; John Church; Michael R Hayden; Lynn A Raymond
Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13614-23.
2007: TAMARA RATOVITSKI; Masayuki Nakamura; James D'Ambola; Ekaterine Chighladze; Yideng Liang; Wenfei Wang; Graham Kyrenia Rona; Michael R Hayden; David R Borchelt; RICKY HIRSCHHORN; Christopher A Ross
N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.
Cell cycle (Georgetown, Tex.) 2007;6(23):2970-81.
2007: Alex Parker; Martina Metzler; John Georgiou; Marilyne Mage; John C Roder; Ann M Rose; Michael R Hayden; Christian Néri
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):11056-64.
2007: Marta Valenza; Jeffrey B Carroll; Valerio Leoni; Lisa N Bertram; Ingeman Björkhem; Roshni R Singaraja; Stefano Di Donato; Dieter Lutjohann; Michael R Hayden; Elena Cattaneo
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.
Human molecular genetics 2007;16(18):2187-98.
2007: William Thomas Gibson; Michael R Hayden
Mycophenolate mofetil and atherosclerosis: results of animal and human studies.
Annals of the New York Academy of Sciences 2007;1110():209-21.
2007: Colin J D Ross; Bruce Carleton; Dana G Warn; Sunita B Stenton; Shahrad Rod Rassekh; Michael R Hayden
Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children.
Annals of the New York Academy of Sciences 2007;1110():177-92.
2007: Alexandre Kuhn; Darlene R Goldstein; Angela Hodges; Andrew D Strand; Thierry Sengstag; Charles Kooperberg; Kristina Becanovic; Mahmoud A Pouladi; Kirupa Sathasivam; Jang-Ho Cha; Anthony J Hannan; Michael R Hayden; Blair R Leavitt; Stephen B Dunnett; Robert J Ferrante; Roger L Albin; Peggy F Shelbourne; Mauro Delorenzi; Sarah J Augood; Richard L M Faull; James M Olson; Gillian P Bates; Lesley Jones; Ruth Luthi-Carter
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Human molecular genetics 2007;16(15):1845-61.
2007: Shannon A Johnson; Julie C Stout; Andrea C Solomon; Douglas R Langbehn; Elizabeth H Aylward; Christina B Cruce; Christopher A Ross; Martha Nance; Elise Kayson; Elaine Julian-Baros; Michael R Hayden; Karl Kieburtz; Mark Guttman; David Oakes; Ira Shoulson; Leigh J Beglinger; Kevin Duff; Elizabeth Penziner; Jane S Paulsen
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease.
Brain : a journal of neurology 2007;130(Pt 7):1732-44.
2007: Caroline L Benn; E J Slow; Laurie A Farrell; Graham Kyrenia Rona; Y Deng; Michael R Hayden; Jang-Ho Cha
Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.
Neuroscience 2007;147(2):354-72.
2007: Jeremy M van Raamsdonk; Zoe Murphy; David M Selva; Reza Hamidizadeh; Jacqueline Pearson; Asa Petersén; Maria Björkqvist; Cameron Muir; Ian R A Mackenzie; Geoffrey L Hammond; A Wayne Vogl; Michael R Hayden; Blair R Leavitt
Testicular degeneration in Huntington disease.
Neurobiology of disease 2007;26(3):512-20.
2007: Jeremy M van Raamsdonk; Simon Warby; Michael R Hayden
Selective degeneration in YAC mouse models of Huntington disease.
Brain research bulletin 2007;72(2-3):124-31.
2007: Kathleen M Giacomini; Ronald M Krauss; Dan Mark Roden; Michel Eichelbaum; Michael R Hayden; Yusuke Nakamura
When good drugs go bad.
Nature 2007;446(7139):975-7.
2007: Andrea C Solomon; Julie C Stout; Shannon A Johnson; Douglas R Langbehn; Elizabeth H Aylward; Jason Brandt; Christopher A Ross; Leigh J Beglinger; Michael R Hayden; Karl Kieburtz; Elise Kayson; Elaine Julian-Baros; Kevin Duff; Mark Guttman; Martha Nance; David Oakes; Ira Shoulson; Elizabeth Penziner; Jane S Paulsen
Verbal episodic memory declines prior to diagnosis in Huntington's disease.
Neuropsychologia 2007;45(8):1767-76.
2007: Mannie M Y Fan; Herman B Fernandes; Lily Y J Zhang; Michael R Hayden; Lynn A Raymond
Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3768-79.
2007: Y Paul Goldberg; Julie MacFarlane; Marcia L E MacDonald; Jay Thompson; M-P Dube; M Mattice; R Fraser; Clint Young; S Hossain; T Pape; B Payne; Christopher C Radomski; G Donaldson; E Ives; J Cox; H Banfield Younghusband; Roger C Green; A Duff; E Boltshauser; G A Grinspan; J H Dimon; B G Sibley; Generoso Andria; Ennio Toscano; J Kerdraon; D Bowsher; Simon N Pimstone; Mark E Samuels; R Sherrington; Michael R Hayden
Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations.
Clinical genetics 2007;71(4):311-9.
2007: Jeremy M van Raamsdonk; Martina Metzler; Elizabeth J Slow; Jacqueline Pearson; Claudia Schwab; Jeffrey Carroll; Graham Kyrenia Rona; Blair R Leavitt; Michael R Hayden
Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.
Neurobiology of disease 2007;26(1):189-200.
2007: Veronica Hirsch-Reinshagen; Jeniffer Y Chan; Anna Wilkinson; Tracie Tanaka; Jianjia Fan; George Ou; Luis F Maia; Roshni R Singaraja; Michael R Hayden; Cheryl L Wellington
Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.
Journal of lipid research 2007;48(4):914-23.
2007: Colin J D Ross; Hagit Katzov; Bruce Carleton; Michael R Hayden
Pharmacogenomics and its implications for autoimmune disease.
Journal of autoimmunity 2007;28(2-3):122-8.
2007: Liam R Brunham; Janine K Kruit; Terry D Pape; Jenelle M Timmins; Anne Q Reuwer; Zainisha Vasanji; Brad J Marsh; Brian Rodrigues; James D Johnson; John S Parks; C Bruce Verchere; Michael R Hayden
Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Nature medicine 2007;13(3):340-7.
2007: Yvonne Bombard; Elizabeth Penziner; J Decolongon; M L N Klimek; Susan Creighton; Oksana Suchowersky; Mark Guttman; Jane S Paulsen; J L Bottorff; Michael R Hayden
Managing genetic discrimination: strategies used by individuals found to have the Huntington disease mutation.
Clinical genetics 2007;71(3):220-31.
2007: Karine Khatchadourian; Charles E Smith; Martina Metzler; Mary Gregory; Michael R Hayden; Daniel G Cyr; Louis Hermo
Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice.
Molecular reproduction and development 2007;74(3):341-59.
2007: Martina Metzler; Lu Gan; Tak Pan Wong; Lidong Liu; Jeffrey R Helm; Lili Liu; John Georgiou; Yushan Wang; Nagat Bissada; Kevin Cheng; John C Roder; Yu Tian Wang; Michael R Hayden
NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(9):2298-308.
2007: Paul C Orban; Rebecca S Devon; Michael R Hayden; Blair R Leavitt
Chapter 15 Juvenile amyotrophic lateral sclerosis.
Handbook of clinical neurology 2007;82():301-12.
2007: Stefanie L Butland; Rebecca S Devon; Yong Huang; Carri-Lyn Mead; Alison M Meynert; Scott J Neal; Soo Sen Lee; Anna Wilkinson; George S Yang; Macaire M S Yuen; Michael R Hayden; Robert A Holt; Blair R Leavitt; B F Francis Ouellette
CAG-encoded polyglutamine length polymorphism in the human genome.
BMC genomics 2007;8():126.
2007: Jinyu Wang; Xunde Xian; Wei Huang; Li Chen; Liling Wu; Yi Zhu; Jianglin Fan; Colin Ross; Michael R Hayden; George Liu
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):197-203.
2006: Caroline Houde; Robin J Dickinson; Vicky M Houtzager; Rebecca Cullum; Rachel Montpetit; Martina Metzler; Elizabeth M Simpson; Sophie Roy; Michael R Hayden; Pamela A Hoodless; Donald W Nicholson
Hippi is essential for node cilia assembly and Sonic hedgehog signaling.
Developmental biology 2006;300(2):523-33.
2006: Yu Zhang; Blair R Leavitt; Jeremy M van Raamsdonk; Ioannis Dragatsis; Dan Goldowitz; Marcy E MacDonald; Michael R Hayden; Robert M Friedlander
Huntingtin inhibits caspase-3 activation.
The EMBO journal 2006;25(24):5896-906.
2006: Shotaro Kishikawa; Jian-Liang Li; Tammy Gillis; Michael M Hakky; Simon Warby; Michael R Hayden; Marcy E MacDonald; Richard H Myers; James Gusella
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.
Neurobiology of disease 2006;24(2):280-5.
2006: Jorge Oliveira; Sylvia Chen; Sandra Almeida; Rebeccah Riley; Jorge Gonçalves; Catarina R Oliveira; Michael R Hayden; David G Nicholls; Lisa M Ellerby; A Cristina Rego
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):11174-86.
2006: Blair R Leavitt; Michael R Hayden
Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?
Nature clinical practice. Neurology 2006;2(10):536-7.
2006: A Semaka; Susan Creighton; Simon Warby; Michael R Hayden
Predictive testing for Huntington disease: interpretation and significance of intermediate alleles.
Clinical genetics 2006;70(4):283-94.
2006: Braydon L Burgess; Sean A McIsaac; Kathryn E Naus; Jeniffer Y Chan; Gavin H Tansley; Jing Yang; Fudan Miao; Colin J D Ross; Miranda van Eck; Michael R Hayden; William E Van Nostrand; Peter St George-Hyslop; David Westaway; Cheryl L Wellington
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Neurobiology of disease 2006;24(1):114-27.
2006: Liam R Brunham; Janine K Kruit; Terry D Pape; John S Parks; Folkert Kuipers; Michael R Hayden
Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Circulation research 2006;99(7):672-4.
2006: Roshni R Singaraja; Miranda van Eck; Nagat Bissada; Francesca Zimetti; Heidi L Collins; Reeni B Hildebrand; Anna Hayden; Liam R Brunham; Martin H Kang; Jean-Charles Fruchart; Theo Van berkel; John S Parks; Bart Staels; George H Rothblat; Catherine Fiévet; Michael R Hayden
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Circulation 2006;114(12):1301-9.
2006: Roshni R Singaraja; Henk Visscher; Erick R James; Angeliki Chroni; Jonathan M Coutinho; Liam R Brunham; Martin H Kang; Vassilis I Zannis; Giovanna Chimini; Michael R Hayden
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
Circulation research 2006;99(4):389-97.
2006: C Alvarez; Stephen J Tredwell; Mary A De Vera; Michael R Hayden
The genotype-phenotype correlation of hereditary multiple exostoses.
Clinical genetics 2006;70(2):122-30.
2006: Elizabeth J Slow; Graham Kyrenia Rona; Michael R Hayden
To be or not to be toxic: aggregations in Huntington and Alzheimer disease.
Trends in genetics : TIG 2006;22(8):408-11.
2006: Roshni R Singaraja; Bjorn Stahmer; May Brundert; Martin Merkel; Joerg Heeren; Nagat Bissada; Martin Kang; Jenelle M Timmins; Rajasekhar Ramakrishnan; John S Parks; Michael R Hayden; Franz Rinninger
Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1821-7.
2006: Maria Björkqvist; Asa Petersén; J Nielsen; D Ecker; Hindrik Mulder; Michael R Hayden; B Landwehrmeyer; Patrik Brundin; Blair R Leavitt
Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.
Clinical genetics 2006;70(1):78-9.
2006: Paolo Guidetti; Gillian P Bates; Graham Kyrenia Rona; Michael R Hayden; Blair R Leavitt; Marcy E MacDonald; Elizabeth J Slow; Vanessa C Wheeler; Ben Woodman; Robert Schwarcz
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Neurobiology of disease 2006;23(1):190-7.
2006: Rebecca S Devon; Paul C Orban; Kimberly Gerrow; M A Barbieri; Claudia Schwab; Li-Ping Cao; Jeffrey R Helm; Nagat Bissada; R Cruz-Aguado; T-L Davidson; J Witmer; Martina Metzler; C K Lam; Wolfram Tetzlaff; Elizabeth M Simpson; J M McCaffery; A E El-Husseini; Blair R Leavitt; Michael R Hayden
Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9595-600.
2006: Graham Kyrenia Rona; Yu Deng; Elizabeth J Slow; Brendan Haigh; Nagat Bissada; Ge Lu; Jacqueline Pearson; Jacqueline Shehadeh; Lisa N Bertram; Zoe Murphy; Simon Warby; Crystal N Doty; Sophie Roy; Cheryl L Wellington; Blair R Leavitt; Lynn A Raymond; Donald W Nicholson; Michael R Hayden
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Cell 2006;125(6):1179-91.
2006: Jane S Paulsen; Michael R Hayden; Julie C Stout; Douglas R Langbehn; Elizabeth H Aylward; Christopher A Ross; Mark Guttman; Martha Nance; Karl Kieburtz; David Oakes; Ira Shoulson; Elise Kayson; Shannon Johnson; Elizabeth Penziner
Preparing for preventive clinical trials: the Predict-HD study.
Archives of neurology 2006;63(6):883-90.
2006: Anat Yanai; Kun Huang; Rujun Kang; Roshni R Singaraja; Pamela Arstikaitis; Lu Gan; Paul C Orban; Asher Mullard; Catherine M Cowan; Lynn A Raymond; Renaldo C Drisdel; William N Green; Brinda Ravikumar; David C Rubinsztein; Alaa El-Husseini; Michael R Hayden
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nature neuroscience 2006;9(6):824-31.
2006: Jaap Rip; Melchior C Nierman; Colin J D Ross; J Wouter Jukema; Michael R Hayden; John J P Kastelein; Erik S G Stroes; Jan Albert Kuivenhoven
Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):1236-45.
2006: Colin J D Ross; Jaap Twisk; Andrew C Bakker; Fudan Miao; Dennis Verbart; Jaap Rip; Tamara Godbey; Paul A Dijkhuizen; Wim T Hermens; John J P Kastelein; Jan Albert Kuivenhoven; Janneke M Meulenberg; Michael R Hayden
Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation.
Human gene therapy 2006;17(5):487-99.
2006: Jeremy M van Raamsdonk; William T Gibson; Jacqueline Pearson; Zoe Murphy; Ge Lu; Blair R Leavitt; Michael R Hayden
Body weight is modulated by levels of full-length huntingtin.
Human molecular genetics 2006;15(9):1513-23.
2006: Liam R Brunham; Janine K Kruit; Jahangir Iqbal; Catherine Fievet; Jenelle M Timmins; Terry D Pape; Bryan Coburn; Nagat Bissada; Bart Staels; Albert K Groen; M Mahmood Hussain; John S Parks; Folkert Kuipers; Michael R Hayden
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
The Journal of clinical investigation 2006;116(4):1052-62.
2006: Miranda van Eck; Roshni R Singaraja; Dan Ye; Reeni B Hildebrand; Erick R James; Michael R Hayden; Theo Van berkel
Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):929-34.
2006: Tieqiang Zhao; Jun Guo; Hui Li; Wei Huang; Xunde Xian; Colin J D Ross; Michael R Hayden; Zongyao Wen; George Liu
Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia.
Biochemical and biophysical research communications 2006;341(4):1066-71.
2006: Byoung-Il Bae; Makoto R Hara; Matthew Cascio; Cheryl L Wellington; Michael R Hayden; Christopher A Ross; Hyo Chol Ha; Xiao-Jiang Li; Solomon H Snyder; Akira Sawa
Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3405-9.
2006: Blair R Leavitt; Jeremy M van Raamsdonk; Jacqueline Shehadeh; Herman B Fernandes; Zoe Murphy; Graham Kyrenia Rona; Cheryl L Wellington; Lynn A Raymond; Michael R Hayden
Wild-type huntingtin protects neurons from excitotoxicity.
Journal of neurochemistry 2006;96(4):1121-9.
2006: Simon Warby; Marcia MacDonald; Michael R Hayden; Stefanie Butland; Francis Ouellette
FASA-57 cDNA shares no homology with coding sequence of HD gene.
Journal of reproductive immunology 2006;69(1):9-10; author reply 11.
2006: Sander I van Leuven; John J P Kastelein; Anthony C Allison; Michael R Hayden; Erik S G Stroes
Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles?
Cardiovascular research 2006;69(2):341-7.
2006: Graham Kyrenia Rona; Elizabeth J Slow; Yu Deng; Nagat Bissada; Ge Lu; Jacqueline Pearson; Jacqueline Shehadeh; Blair R Leavitt; Lynn A Raymond; Michael R Hayden
Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.
Neurobiology of disease 2006;21(2):444-55.
2006: Jacqueline Shehadeh; Herman B Fernandes; Melinda M Zeron Mullins; Graham Kyrenia Rona; Blair R Leavitt; Michael R Hayden; Lynn A Raymond
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease.
Neurobiology of disease 2006;21(2):392-403.
2006: Jeremy M van Raamsdonk; Jacqueline Pearson; Zoe Murphy; Michael R Hayden; Blair R Leavitt
Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.
BMC neuroscience 2006;7():80.
2006: Jian-Liang Li; Michael R Hayden; Simon Warby; Alexandra Durr; Patrick J Morrison; Martha Nance; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Ferdinando Squitieri; Luigi Frati; Estrella Gómez-Tortosa; Carmen Ayuso García; Oksana Suchowersky; Mary Lou Klimek; Ronald J A Trent; Elizabeth McCusker; Andrea Novelletto; Marina Frontali; Jane S Paulsen; Randi Jones; Tetsuo Ashizawa; Alice Lazzarini; Vanessa C Wheeler; Ranjana Prakash; Gang Xu; Luc Djoussé; Jayalakshmi Srinidhi Mysore; Tammy Gillis; Michael Hakky; L Adrienne Cupples; Marie H Saint-Hilaire; Jang-Ho Cha; Steven M Hersch; John B Penney; Madaline B Harrison; Susan L Perlman; Andrea Zanko; Ruth K Abramson; Anthony J Lechich; Ayana Duckett; Karen Marder; P Michael Conneally; James Gusella; Marcy E MacDonald; Richard H Myers
Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.
BMC medical genetics 2006;7():71.
2006: Liam R Brunham; Roshni R Singaraja; Michael R Hayden
Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.
Annual review of nutrition 2006;26():105-29.
2005: Veronica Hirsch-Reinshagen; Luis F Maia; Braydon L Burgess; Jean-Francois Blain; Kathryn E Naus; Sean A McIsaac; Pamela F Parkinson; Jeniffer Y Chan; Gavin H Tansley; Michael R Hayden; Judes Poirier; William E Van Nostrand; Cheryl L Wellington
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
The Journal of biological chemistry 2005;280(52):43243-56.
2005: Jeremy M van Raamsdonk; Zoe Murphy; Elizabeth J Slow; Blair R Leavitt; Michael R Hayden
Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.
Human molecular genetics 2005;14(24):3823-35.
2005: Liam R Brunham; Roshni R Singaraja; Terry D Pape; Anish Kejariwal; Paul D Thomas; Michael R Hayden
Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene.
PLoS genetics 2005;1(6):e83.
2005: Jeremy M van Raamsdonk; Jacqueline Pearson; Daniel A Rogers; Ge Lu; Vilte E Barakauskas; Alasdair M Barr; William Honer; Michael R Hayden; Blair R Leavitt
Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.
Experimental neurology 2005;196(2):266-72.
2005: Jaap Rip; Melchior C Nierman; Jeroen A Sierts; Wilma Petersen; Karin van den Oever; Daniel Van Raalte; Colin J D Ross; Michael R Hayden; Andrew C Bakker; Paul A Dijkhuizen; Wim T Hermens; Jaap Twisk; Erik S G Stroes; John J P Kastelein; Jan Albert Kuivenhoven; Janneke M Meulenberg
Gene therapy for lipoprotein lipase deficiency: working toward clinical application.
Human gene therapy 2005;16(11):1276-86.
2005: Kimberly B Kegel; Ellen Sapp; Jennifer Yoder; Benjamin G Cuiffo; Lindsay Sobin; Yun J Kim; Zheng-Hong Qin; Michael R Hayden; Neil Aronin; David L Scott; Gerhard Isenberg; Wolfgang H Goldmann; Marian DiFiglia
Huntingtin associates with acidic phospholipids at the plasma membrane.
The Journal of biological chemistry 2005;280(43):36464-73.
2005: Jeremy M van Raamsdonk; Jacqueline Pearson; Craig D C Bailey; Daniel A Rogers; Gail Johnson; Michael R Hayden; Blair R Leavitt
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.
Journal of neurochemistry 2005;95(1):210-20.
2005: Sander I van Leuven; John J P Kastelein; Michael R Hayden; David d'Cruz; Graham R Hughes; Erik S G Stroes
Cardiovascular disease in systemic lupus erythematosus: has the time for action come?
Current opinion in lipidology 2005;16(5):501-6.
2005: Bruce G Jenkins; Ole A Andreassen; Alpaslan Dedeoglu; Blair R Leavitt; Michael R Hayden; David R Borchelt; Christopher A Ross; Robert J Ferrante; M Flint Beal
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
Journal of neurochemistry 2005;95(2):553-62.
2005: Roshni R Singaraja; Erick R James; Jennifer Crim; Henk Visscher; Alu Chatterjee; Michael R Hayden
Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1.
Journal of lipid research 2005;46(10):2061-71.
2005: Colin J D Ross; Guoqing Liu; Jan Albert Kuivenhoven; Jaap Twisk; Jaap Rip; Willemijn van Dop; Katherine J D Ashbourne Excoffon; Suzanne M E Lewis; John J Kastelein; Michael R Hayden
Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2143-50.
2005: Elizabeth J Slow; Graham Kyrenia Rona; Alexander Osmand; Rebecca S Devon; Ge Lu; Yu Deng; Jacqueline Pearson; Kuljeet S Vaid; Nagat Bissada; Ronald B. Wetzel; Blair R Leavitt; Michael R Hayden
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11402-7.
2005: John Pinto; Jeremy M van Raamsdonk; Blair R Leavitt; Michael R Hayden; Thomas M Jeitner; Howard T Thaler; Boris Krasnikov; Arthur J L Cooper
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
Journal of neurochemistry 2005;94(4):1087-101.
2005: Basant K Puri; Blair R Leavitt; Michael R Hayden; Christopher A Ross; Adam Rosenblatt; J Timothy Greenamyre; Steven M Hersch; Krishna S Vaddadi; A Sword; David F Horrobin; Mehar Manku; Harald Murck
Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial.
Neurology 2005;65(2):286-92.
2005: Simon Warby; Edmond Y W Chan; Martina Metzler; Lu Gan; Roshni R Singaraja; Susan F Crocker; Harold A Robertson; Michael R Hayden
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Human molecular genetics 2005;14(11):1569-77.
2005: Jonathan M Coutinho; Roshni R Singaraja; Martin Kang; David J Arenillas; Lisa N Bertram; Nagat Bissada; Bart Staels; Jean-Charles Fruchart; Catherine Fievet; Ann M Joseph-George; Wyeth W Wasserman; Michael R Hayden
Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis.
Journal of lipid research 2005;46(6):1113-23.
2005: Jeremy M van Raamsdonk; Jacqueline Pearson; Daniel A Rogers; Nagat Bissada; A Wayne Vogl; Michael R Hayden; Blair R Leavitt
Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.
Human molecular genetics 2005;14(10):1379-92.
2005: Jenelle M Timmins; Ji-Young Lee; Elena Boudyguina; Kimberly D Kluckman; Liam R Brunham; Anny Mulya; Abraham K Gebre; Jonathan M Coutinho; Perry L Colvin; Thomas L Smith; Michael R Hayden; Nobuyo Maeda; John S Parks
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.
The Journal of clinical investigation 2005;115(5):1333-42.
2005: Jeremy M van Raamsdonk; Jacqueline Pearson; Elizabeth J Slow; Sazzad M Hossain; Blair R Leavitt; Michael R Hayden
Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(16):4169-80.
2005: Rebecca S Devon; Claudia Schwab; Justin D Topp; Paul C Orban; Yu-Zhou Yang; Terry D Pape; Jeffrey R Helm; Tara-Lynne Davidson; Daniel A Rogers; François Gros-Louis; Guy Rouleau; Bruce F Horazdovsky; Blair R Leavitt; Michael R Hayden
Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood.
Neurobiology of disease 2005;18(2):243-57.
2005: Valerie Legendre-Guillemin; Martina Metzler; Jean-Francois Lemaire; Jacynthe Philie; Lu Gan; Michael R Hayden; Peter S McPherson
Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.
The Journal of biological chemistry 2005;280(7):6101-8.
2005: Tie-Shan Tang; Elizabeth J Slow; Vitalie Lupu; Irina G Stavrovskaya; Mutsuyuki Sugimori; Rodolfo R Llinás; Bruce Kristal; Michael R Hayden; Ilya Bezprozvanny
Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2602-7.
2005: Michael R Hayden; Yvonne Bombard
Psychosocial effects of predictive testing for Huntington's disease.
Advances in neurology 2005;96():226-39.
2004: Kun Huang; Anat Yanai; Rujun Kang; Pamela Arstikaitis; Roshni R Singaraja; Martina Metzler; Asher Mullard; Brendan Haigh; Catherine Gauthier-Campbell; Claire-Anne Gutekunst; Michael R Hayden; Alaa El-Husseini
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Neuron 2004;44(6):977-86.
2004: Russell L Margolis; Susan E Holmes; Adam Rosenblatt; Lisa M Gourley; Elizabeth O'Hearn; Christopher A Ross; William K Seltzer; Ruth H Walker; Tetsuo Ashizawa; Astrid Rasmussen; Michael R Hayden; Elisabeth W Almqvist; Juliette Harris; Stanley Fahn; Marcy E MacDonald; Jayalakshmi Mysore; Takayoshi Shimohata; Shoji Tsuji; Nicholas T Potter; Kazuhiro Nakaso; Yoshiki Adachi; Kenji Nakashima; Thomas D Bird; Amanda Krause; Penny Greenstein
Huntington's Disease-like 2 (HDL2) in North America and Japan.
Annals of neurology 2004;56(5):670-4.
2004: Jing-Zhi Guan; Naoki Tamasawa; Liam R Brunham; Jun Matsui; Hiroshi Murakami; Toshihiro Suda; Shigeru Ochiai; Masahiro Tsutsui; Kenji Kudou; Kei Satoh; Michael R Hayden
A case of Tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1.
American journal of medical genetics. Part A 2004;130A(4):398-401.
2004: Lijun Li; Timothy H Murphy; Michael R Hayden; Lynn A Raymond
Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease.
Journal of neurophysiology 2004;92(5):2738-46.
2004: G Kees Hovingh; Alison Brownlie; Radjesh J Bisoendial; Marie Pierre Dube; Johannes Levels; Wilma Petersen; R P F Dullaart; Erik S G Stroes; Aeilko H Zwinderman; Eric de Groot; Michael R Hayden; Jan Albert Kuivenhoven; John J P Kastelein
A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease.
Journal of the American College of Cardiology 2004;44(7):1429-35.
2004: Tie-Shan Tang; Huiping Tu; Paul C Orban; Edmond Y W Chan; Michael R Hayden; Ilya Bezprozvanny
HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons.
The European journal of neuroscience 2004;20(7):1779-87.
2004: Ilya Bezprozvanny; Michael R Hayden
Deranged neuronal calcium signaling and Huntington disease.
Biochemical and biophysical research communications 2004;322(4):1310-7.
2004: Veronica Hirsch-Reinshagen; Steven Zhou; Braydon L Burgess; Lise Bernier; Sean A McIsaac; Jeniffer Y Chan; Gavin H Tansley; Jeffrey S Cohn; Michael R Hayden; Cheryl L Wellington
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.
The Journal of biological chemistry 2004;279(39):41197-207.
2004: Colin J D Ross; Jaap Twisk; Janneke M Meulenberg; Guoqing Liu; Karin van den Oever; Ewoud Moraal; Wim T Hermens; Jaap Rip; John J P Kastelein; Jan Albert Kuivenhoven; Michael R Hayden
Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL(S447X) beneficial mutation.
Human gene therapy 2004;15(9):906-19.
2004: Luc Djoussé; Beth Knowlton; Michael R Hayden; Elisabeth W Almqvist; Ryan R Brinkman; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Alexandra Durr; Catherine Dode; Patrick J Morrison; Andrea Novelletto; Marina Frontali; Ronald J Trent; Elizabeth A McCusker; Estrella Gómez-Tortosa; David Mayo Cabrero; Randi Jones; Andrea Zanko; Martha Nance; Ruth K Abramson; Oksana Suchowersky; Jane S Paulsen; Madaline B Harrison; Qiong Yang; L Adrienne Cupples; Jayalakshmi Mysore; James Gusella; Marcy E MacDonald; Richard H Myers
Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.
Neurogenetics 2004;5(2):109-14.
2004: David M Selva; Veronica Hirsch-Reinshagen; Braydon L Burgess; Steven Zhou; Jeniffer Chan; Sean A McIsaac; Michael R Hayden; Geoffrey L Hammond; A Wayne Vogl; Cheryl L Wellington
The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.
Journal of lipid research 2004;45(6):1040-50.
2004: Juliette Gafni; Evan Hermel; Jessica E Young; Cheryl L Wellington; Michael R Hayden; Lisa M Ellerby
Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
The Journal of biological chemistry 2004;279(19):20211-20.
2004: Maya Saleh; John P Vaillancourt; Graham Kyrenia Rona; Matthew Huyck; Srinivasa M Srinivasula; Emad S Alnemri; Martin H Steinberg; Vikki G Nolan; Clinton T Baldwin; Richard S Hotchkiss; Timothy G Buchman; Barbara A Zehnbauer; Michael R Hayden; Lindsay A Farrer; Sophie Roy; Donald W Nicholson
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2004: Martin B Delatycki; Katrina J Allen; P Gow; Julie MacFarlane; Christopher C Radomski; Jay Thompson; Michael R Hayden; Y Paul Goldberg; Mark E Samuels
A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis.
Clinical genetics 2004;65(5):378-83.
2004: Ronald G Lafreniere; Marcia L E MacDonald; Marie-Pierre Dube; Julie MacFarlane; Mary O'Driscoll; Bernard Brais; Sebastien Meilleur; Ryan R Brinkman; Owen Dadivas; Terry Pape; Christele Platon; Christopher C Radomski; Jenni Risler; Jay Thompson; Ana-Maria Guerra-Escobio; Gudarz Davar; Xandra O Breakefield; Simon N Pimstone; Roger C Green; William Pryse-Phillips; Y Paul Goldberg; H Banfield Younghusband; Michael R Hayden; Robin Sherrington; Guy Rouleau; Mark E Samuels
Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates.
American journal of human genetics 2004;74(5):1064-73.
2004: Peter S Harper; Sjef Gevers; Guido de Wert; Susan Creighton; Yvonne Bombard; Michael R Hayden
Genetic testing and Huntington's disease: issues of employment.
Lancet neurology 2004;3(4):249-52.
2004: Douglas R Langbehn; Ryan R Brinkman; D Falush; Jane S Paulsen; Michael R Hayden
A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.
Clinical genetics 2004;65(4):267-77.
2004: Evan Hermel; Juliette Gafni; Stephanie Propp; Blair R Leavitt; Cheryl L Wellington; Jessica E Young; Abigail S Hackam; Anna Logvinova; Alyson Peel; Sylvia F Chen; Vivian Y H Hook; Roshni R Singaraja; Stan Krajewski; Paul Goldsmith; H Michael Ellerby; Michael R Hayden; Dale E Bredesen; Lisa M Ellerby
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Cell death and differentiation 2004;11(4):424-38.
2004: Melinda M Zeron; Herman B Fernandes; Claudia Krebs; Jacqueline Shehadeh; Cheryl L Wellington; Blair R Leavitt; Kenneth G Baimbridge; Michael R Hayden; Lynn A Raymond
Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease.
Molecular and cellular neurosciences 2004;25(3):469-79.
2004: G Kees Hovingh; Jan Albert Kuivenhoven; Radjesh J Bisoendial; Albert K Groen; Marjel J van Dam; Arie Van Tol; Cheryl L Wellington; Michael R Hayden; August Smelt; J J P Kastelein
HDL deficiency and atherosclerosis: lessons from Tangier disease.
Journal of internal medicine 2004;255(2):299-301.
2004: Zheng-Hong Qin; Yumei Wang; Ellen Sapp; Benjamin G Cuiffo; Erich E Wanker; Michael R Hayden; Kimberly B Kegel; Neil Aronin; Marian DiFiglia
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(1):269-81.
2004: Diana Zala; Jean-Charles Bensadoun; Luis de Almeida; Blair R Leavitt; Claire-Anne Gutekunst; Patrick Aebischer; Michael R Hayden; Nicole Deglon
Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice.
Experimental neurology 2004;185(1):26-35.
2004: George Papanikolaou; Mark E Samuels; Erwin H Ludwig; Marcia L E MacDonald; Patrick L Franchini; Marie-Pierre Dubé; Lisa Andres; Julie MacFarlane; Nikos Sakellaropoulos; Marianna Politou; Elizabeta Nemeth; Jay Thompson; Jenni K Risler; Catherine Zaborowska; Ryan Babakaiff; Christopher C Radomski; Terry D Pape; Owen Davidas; John Christakis; Pierre Brissot; Gillian Lockitch; Tomas Ganz; Michael R Hayden; Y Paul Goldberg
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.
Nature genetics 2004;36(1):77-82.
2003: Elizabeth H Aylward; Adam Rosenblatt; Katherine M Field; Venu Yallapragada; Karl Kieburtz; M McDermott; Lynn A Raymond; Elisabeth W Almqvist; Michael R Hayden; Christopher A Ross
Caudate volume as an outcome measure in clinical trials for Huntington's disease: a pilot study.
Brain research bulletin 2003;62(2):137-41.
2003: Ferdinando Squitieri; E W Almqvist; Milena Cannella; giuliana cislaghi; Michael R Hayden
Predictive testing for persons at risk for homozygosity for CAG expansion in the Huntington disease gene.
Clinical genetics 2003;64(6):524-5.
2003: Collette K Hand; Rebecca S Devon; François Gros-Louis; Daniel Rochefort; Jawad Khoris; Vincent Meininger; Jean-Pierre Bouchard; William Camu; Michael R Hayden; Guy Rouleau
Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis.
Archives of neurology 2003;60(12):1768-71.
2003: Jan Albert Kuivenhoven; G Kees Hovingh; Arie Van Tol; M Jauhiainen; C Ehnholm; Jean-Charles Fruchart; E A Brinton; J D Otvos; August Smelt; A Brownlee; Aeilko H Zwinderman; Michael R Hayden; J J P Kastelein
Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size.
Atherosclerosis 2003;171(2):311-9.
2003: Lijun Li; Mannie Fan; Carolyn D Icton; Nansheng Chen; Blair R Leavitt; Michael R Hayden; Timothy H Murphy; Lynn A Raymond
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.
Neurobiology of aging 2003;24(8):1113-21.
2003: Liam R Brunham; Michael R Hayden
Clarity is essential when using nucleotide number systems.
Atherosclerosis 2003;170(2):349.
2003: Elisabeth W Almqvist; Ryan R Brinkman; S Wiggins; Michael R Hayden
Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease.
Clinical genetics 2003;64(4):300-9.
2003: Yu Zhang; Mingwei Li; Martin Drozda; Minghua Chen; Shengjun Ren; Rene O Mejia Sanchez; Blair R Leavitt; Elena Cattaneo; Robert J Ferrante; Michael R Hayden; Robert M Friedlander
Depletion of wild-type huntingtin in mouse models of neurologic diseases.
Journal of neurochemistry 2003;87(1):101-6.
2003: Rebecca S Devon; Jeffrey R Helm; Guy Rouleau; Y Leitner; Tally Lerman-Sagie; D Lev; Michael R Hayden
The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings.
Clinical genetics 2003;64(3):210-5.
2003: Jian-Liang Li; Michael R Hayden; Elisabeth W Almqvist; Ryan R Brinkman; Alexandra Durr; Catherine Dodé; Patrick J Morrison; Oksana Suchowersky; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Estrella Gómez-Tortosa; David Mayo Cabrero; Andrea Novelletto; Marina Frontali; Martha Nance; Ronald J A Trent; Elizabeth McCusker; Randi Jones; Jane S Paulsen; Madeline Harrison; Andrea Zanko; Ruth K Abramson; Ana L Russ; Beth Knowlton; Luc Djoussé; Jayalakshmi S Mysore; Suzanne Tariot; Michael F Gusella; Vanessa C Wheeler; Larry D Atwood; L Adrienne Cupples; Marie Saint-Hilaire; Jang-Ho J Cha; Steven M Hersch; Walter J Koroshetz; James Gusella; Marcy E MacDonald; Richard H Myers
A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study.
American journal of human genetics 2003;73(3):682-7.
2003: Chiara Zuccato; Marzia Tartari; Andrea Crotti; Donato Goffredo; Marta Valenza; Luciano Conti; Tiziana Cataudella; Blair R Leavitt; Michael R Hayden; Tõnis Timmusk; Dorotea Rigamonti; Elena Cattaneo
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Nature genetics 2003;35(1):76-83.
2003: CF Hoogendijk; Charlotte L Scholtz; S M Pimstone; E Ehrenborg; J J P Kastelein; JC Defesche; Rochelle Thiart; Lana du Plessis; Nico de Villiers; Monique G Zaahl; Rhena Delport; David C Rubinsztein; L J Raffel; Clarence Grim; S Mediene-Benchekor; P Amouyel; T Brousseau; Krisela Steyn; Carl Lombard; Michael R Hayden; Maritha J Kotze
Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element.
Molecular and cellular probes 2003;17(4):175-81.
2003: Roshni R Singaraja; Liam R Brunham; Henk Visscher; John J P Kastelein; Michael R Hayden
Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1322-32.
2003: Natasha Hussain; Montarop Yamabhai; Asha L Bhakar; Martina Metzler; Stephen S G Ferguson; Michael R Hayden; Peter S McPherson; Brian Kay
A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding.
The Journal of biological chemistry 2003;278(31):28823-30.
2003: Cheryl L Wellington; Liam R Brunham; Steven Zhou; Roshni R Singaraja; Henk Visscher; Allison Gelfer; Colin Ross; Erick James; Guoqing Liu; Mary T Huber; Yu-Zhou Yang; Robin J Parks; Albert Groen; Jamila Fruchart-Najib; Michael R Hayden
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.
Journal of lipid research 2003;44(8):1470-80.
2003: Tie-Shan Tang; Huiping Tu; Edmond Y W Chan; Anton Maximov; Zhengnan Wang; Cheryl L Wellington; Michael R Hayden; Ilya Bezprozvanny
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.
Neuron 2003;39(2):227-39.
2003: Martina Metzler; Bo Li; Lu Gan; John Georgiou; Claire-Anne Gutekunst; Yushan Wang; Enrique Torre; Rebecca S Devon; Rosemary Oh; Valerie Legendre-Guillemin; Mark Rich; Christine Alvarez; Marina Gertsenstein; Peter S McPherson; Andras Nagy; Yu Tian Wang; John C Roder; Lynn A Raymond; Michael R Hayden
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
The EMBO journal 2003;22(13):3254-66.
2003: Elizabeth J Slow; Jeremy M van Raamsdonk; Daniel Rogers; Sarah H Coleman; Graham Kyrenia Rona; Yu Deng; Rosemary Oh; Nagat Bissada; Sazzad M Hossain; Yu-Zhou Yang; Xiao-Jiang Li; Elizabeth M Simpson; Claire-Anne Gutekunst; Blair R Leavitt; Michael R Hayden
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Human molecular genetics 2003;12(13):1555-67.
2003: Radjesh J Bisoendial; G Kees Hovingh; Johannes Levels; Peter G Lerch; Irmgard Andresen; Michael R Hayden; John J P Kastelein; Erik S G Stroes
Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein.
Circulation 2003;107(23):2944-8.
2003: Luc Djoussé; Beth Knowlton; Michael R Hayden; Elisabeth W Almqvist; Ryan R Brinkman; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Alexandra Durr; Catherine Dode; P J Morrison; Andrea Novelletto; Marina Frontali; Ronald J Trent; Elizabeth A McCusker; Estrella Gómez-Tortosa; D Mayo; R Jones; A Zanko; Martha Nance; Ruth K Abramson; Oksana Suchowersky; Jane S Paulsen; M Harrison; Qiong Yang; L Adrienne Cupples; James Gusella; Marcy E MacDonald; Richard H Myers
Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease.
American journal of medical genetics. Part A 2003;119A(3):279-82.
2003: S Creighton; Elisabeth W Almqvist; D Macgregor; B Fernandez; H Hogg; J Beis; J Philip Welch; C Riddell; R Lokkesmoe; M Khalifa; J MacKenzie; A Sajoo; S Farrell; F Robert; A Shugar; A Summers; Wendy S Meschino; D Allingham-Hawkins; T Chiu; A Hunter; J Allanson; H Hare; J Schween; L Collins; S Sanders; C Greenberg; S Cardwell; Edmond G Lemire; Patrick M MacLeod; Michael R Hayden
Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000.
Clinical genetics 2003;63(6):462-75.
2003: G Kees Hovingh; Michel J A Van Wijland; Alison Brownlie; Radjesh J Bisoendial; Michael R Hayden; John J P Kastelein; Albert K Groen
The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia.
Journal of lipid research 2003;44(6):1251-5.
2003: Jacob D Mulligan; Matthew Flowers; Angie Tebon; J James Bitgood; Cheryl L Wellington; Michael R Hayden; Alan D Attie
ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens.
The Journal of biological chemistry 2003;278(15):13356-66.
2003: Frederick C Nucifora; Lisa M Ellerby; Cheryl L Wellington; Jonathan D Wood; William Joseph Herring; Akira Sawa; Michael R Hayden; Valina Dawson; Ted M Dawson; Christopher A Ross
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.
The Journal of biological chemistry 2003;278(15):13047-55.
2003: Ferdinando Squitieri; Cinzia Gellera; Milena Cannella; Caterina Mariotti; giuliana cislaghi; David C Rubinsztein; Elisabeth W Almqvist; David Turner; Anne-Catherine Bachoud-Lévi; Sheila A Simpson; Martin B Delatycki; Vittorio Maglione; Michael R Hayden; Stefano Di Donato
Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course.
Brain : a journal of neurology 2003;126(Pt 4):946-55.
2003: Michael R Hayden
Predictive testing for Huntington's disease: a universal model?
Lancet neurology 2003;2(3):141-2.
2003: Christy L Beever; Mary D Stephenson; Maria S Peñaherrera; R H Jiang; Dagmar K Kalousek; Michael R Hayden; Leigh Field; Carolyn J Brown; Wendy P Robinson
Skewed X-chromosome inactivation is associated with trisomy in women ascertained on the basis of recurrent spontaneous abortion or chromosomally abnormal pregnancies.
American journal of human genetics 2003;72(2):399-407.
2003: François Gros-Louis; Inge A Meijer; Collette K Hand; Marie-Pierre Dubé; Daune L MacGregor; Marie-Hélène Seni; Rebecca S Devon; Michael R Hayden; Frederick Andermann; Eva Andermann; Guy Rouleau
An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred.
Annals of neurology 2003;53(1):144-5.
2003: Claudine Laurent; Dana J H Niehaus; Stéphanie Bauché; Douglas F Levinson; Stéphane Soubigou; Simon Pimstone; Michael R Hayden; Irena Mbanga; Robin Emsley; Jean-François Deleuze; Jacques Mallet
CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;116B(1):45-50.
2002: Cheryl L Wellington; Yu-Zhou Yang; Stephen Zhou; Susanne M Clee; Bing Tan; Kenichi Hirano; Karin Zwarts; Anita Kwok; Allison Gelfer; Michel Marcil; Scott Newman; Kirsten Roomp; Roshni R Singaraja; Jennifer Collins; Lin-Hua Zhang; Albert K Groen; Kees Hovingh; Alison Brownlie; Sherrie R Tafuri; Jacques Genest; John J P Kastelein; Michael R Hayden
Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.
Journal of lipid research 2002;43(11):1939-49.
2002: Alan D Attie; Ronald M Krauss; Mark P Gray-Keller; Alison Brownlie; Makoto Miyazaki; John J Kastelein; Aldons J Lusis; Anton F H Stalenhoef; Jonathan P Stoehr; Michael R Hayden; James M Ntambi
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia.
Journal of lipid research 2002;43(11):1899-907.
2002: Roshni R Singaraja; Shinji Hadano; Martina Metzler; Scott Givan; Cheryl L Wellington; Simon Warby; Anat Yanai; Claire-Anne Gutekunst; Blair R Leavitt; Hong Yi; Keith Fichter; Lu Gan; Krista McCutcheon; Vikramjit Chopra; Jennifer Michel; Steven M Hersch; Joh-E Ikeda; Michael R Hayden
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Human molecular genetics 2002;11(23):2815-28.
2002: Raymond H See; Rosalinda A Caday-Malcolm; Roshni R Singaraja; Steven Zhou; Anthony Silverston; Mary T Huber; Josh Moran; Erick R James; Rozmin Janoo; Jane M Savill; Veronique Rigot; Lin-Hua Zhang; Minghan Wang; Giovanna Chimini; Cheryl L Wellington; Sherrie R Tafuri; Michael R Hayden
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
The Journal of biological chemistry 2002;277(44):41835-42.
2002: Alan D Attie; Yannick Hamon; Angela R Brooks-Wilson; Mark P Gray-Keller; Marcia L E MacDonald; Veronique Rigot; Angie Tebon; Lin-Hua Zhang; Jacob D Mulligan; Roshni R Singaraja; J James Bitgood; Mark E Cook; John J P Kastelein; Giovanna Chimini; Michael R Hayden
Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.
Journal of lipid research 2002;43(10):1610-7.
2002: Johane Robitaille; Marcia L E MacDonald; Ajamete Kaykas; Laird C Sheldahl; Jutta Zeisler; Marie-Pierre Dubé; Lin-Hua Zhang; Roshni R Singaraja; Duane L Guernsey; Binyou Zheng; Lee F Siebert; Ann Hoskin-Mott; Michael T Trese; Simon N Pimstone; Barkur S Shastry; Randall T Moon; Michael R Hayden; Y Paul Goldberg; Mark E Samuels
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.
Nature genetics 2002;32(2):326-30.
2002: Cheryl L Wellington; Lisa M Ellerby; Claire-Anne Gutekunst; Danny Rogers; Simon Warby; Graham Kyrenia Rona; Odell Loubser; Jeremy M van Raamsdonk; Roshni R Singaraja; Yu-Zhou Yang; Juliette Gafni; Dale E Bredesen; Steven M Hersch; Blair R Leavitt; Sophie Roy; Donald W Nicholson; Michael R Hayden
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7862-72.
2002: Edmond Y W Chan; Ruth Luthi-Carter; Andrew D Strand; Steven M Solano; Sarah A Hanson; Molly M DeJohn; Charles Kooperberg; Kathryn O Chase; Marian DiFiglia; Anne B Young; Blair R Leavitt; Jang-Ho Cha; Neil Aronin; Michael R Hayden; James M Olson
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Human molecular genetics 2002;11(17):1939-51.
2002: Alexander V Panov; Claire-Anne Gutekunst; Blair R Leavitt; Michael R Hayden; James R Burke; Warren J Strittmatter; J Timothy Greenamyre
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
Nature neuroscience 2002;5(8):731-6.
2002: Roshni R Singaraja; Catherine Fievet; Graciela Castro; Erick R James; Nathalie Hennuyer; Susanne M Clee; Nagat Bissada; Jonathan C Choy; Jean-Charles Fruchart; Bruce M McManus; Bart Staels; Michael R Hayden
Increased ABCA1 activity protects against atherosclerosis.
The Journal of clinical investigation 2002;110(1):35-42.
2002: Lei Bu; Yiping Jin; Yuefeng Shi; Renyuan Chu; Airong Ban; Hans Eiberg; Lisa Andres; Haisong Jiang; Guangyong Zheng; Meiqian Qian; Bin Cui; Yu Xia; Jing Liu; Landian Hu; Guoping Zhao; Michael R Hayden; Xiangyin Kong
Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract.
Nature genetics 2002;31(3):276-8.
2002: Marjorie A Ariano; Neil Aronin; Marian DiFiglia; Danilo A Tagle; David R Sibley; Blair R Leavitt; Michael R Hayden; Michael S Levine
Striatal neurochemical changes in transgenic models of Huntington's disease.
Journal of neuroscience research 2002;68(6):716-29.
2002: Valerie Legendre-Guillemin; Martina Metzler; Martine Charbonneau; Lu Gan; Vikramjit Chopra; Jacynthe Philie; Michael R Hayden; Peter S McPherson
HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
The Journal of biological chemistry 2002;277(22):19897-904.
2002: Edmond Y W Chan; Jamal Nasir; Claire-Anne Gutekunst; Sarah Coleman; Alan Maclean; Alex Maas; Martina Metzler; Marina Gertsenstein; Christopher A Ross; Andras Nagy; Michael R Hayden
Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior.
Human molecular genetics 2002;11(8):945-59.
2002: Melinda M Zeron; Oskar Hansson; Nansheng Chen; Cheryl L Wellington; Blair R Leavitt; Patrik Brundin; Michael R Hayden; Lynn A Raymond
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease.
Neuron 2002;33(6):849-60.
2002: Cheryl L Wellington; Elizabeth K-Y Walker; Agripina Suarez; Anita Kwok; Nagat Bissada; Roshni R Singaraja; Yu-Zhou Yang; Lin-Hua Zhang; Erick James; Janet E Wilson; Omar L Francone; Bruce M McManus; Michael R Hayden
ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation.
Laboratory investigation; a journal of technical methods and pathology 2002;82(3):273-83.
2002: Jonas Peterson; Amir F Ayyobi; Yuanhong Ma; Howard Henderson; Manuel Reina; Samir S Deeb; Silvia Santamarina-Fojo; Michael R Hayden; John D Brunzell
Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene.
Journal of lipid research 2002;43(3):398-406.
2002: Karin Zwarts; Susanne M Clee; Aeilko H Zwinderman; J C Engert; Roshni R Singaraja; Odell Loubser; Erick James; Kirsten Roomp; T J Hudson; J Wouter Jukema; J J P Kastelein; Michael R Hayden
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
Clinical genetics 2002;61(2):115-25.
2002: François G Gervais; Roshni R Singaraja; Steven Xanthoudakis; Claire-Anne Gutekunst; Blair R Leavitt; Martina Metzler; Abigail S Hackam; John Tam; John P Vaillancourt; Vicky Houtzager; Dita M Rasper; Sophie Roy; Michael R Hayden; Donald W Nicholson
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nature cell biology 2002;4(2):95-105.
2002: Yoshiharu Nishida; Kenichi Hirano; Kosuke Tsukamoto; Makoto Nagano; Chiaki Ikegami; Kirsten Roomp; Mitsuaki Ishihara; Naoki Sakane; Zhongyan Zhang; Ken-ichi Tsujii Ki; Akifumi Matsuyama; Tohru Ohama; Fumihiko Matsuura; Masato Ishigami; Naohiko Sakai; Hisatoyo Hiraoka; Hiroaki Hattori; Cheryl L Wellington; Yoshihide Yoshida; Susumu Misugi; Michael R Hayden; Toru Egashira; Shizuya Yamashita; Yuji Matsuzawa
Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency.
Biochemical and biophysical research communications 2002;290(2):713-21.
2002: Marjel J van Dam; Eric de Groot; Susanne M Clee; G Kees Hovingh; Roosje Roelants; Angela R Brooks-Wilson; Aeilko H Zwinderman; Andries J Smit; August Smelt; Albert K Groen; Michael R Hayden; John J P Kastelein
Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study.
Lancet 2002;359(9300):37-42.
2001: Carlos Cepeda; Marjorie A Ariano; Christopher R Calvert; Jorge Flores-Hernández; Scott H Chandler; Blair R Leavitt; Michael R Hayden; Michael S Levine
NMDA receptor function in mouse models of Huntington disease.
Journal of neuroscience research 2001;66(4):525-39.
2001: Ferdinando Squitieri; Milena Cannella; Patrizia Giallonardo; Vittorio Maglione; Caterina Mariotti; Michael R Hayden
Onset and pre-onset studies to define the Huntington's disease natural history.
Brain research bulletin 2001;56(3-4):233-8.
2001: Alan D Attie; J P Kastelein; Michael R Hayden
Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis.
Journal of lipid research 2001;42(11):1717-26.
2001: Martina Metzler; Valerie Legendre-Guillemin; Lu Gan; Vikramjit Chopra; Anita Kwok; Peter S McPherson; Michael R Hayden
HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.
The Journal of biological chemistry 2001;276(42):39271-6.
2001: Susanne M Clee; Odell Loubser; J Collins; John J P Kastelein; Michael R Hayden
The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.
Clinical genetics 2001;60(4):293-300.
2001: Shinji Hadano; Collette K Hand; Hitoshi Osuga; Yoshiko Yanagisawa; Asako Otomo; Rebecca S Devon; N Miyamoto; Junko Showguchi-Miyata; Y Okada; Roshni R Singaraja; D A Figlewicz; T Kwiatkowski; B A Hosler; Tally Lerman-Sagie; Jennifer Skaug; Jamal Nasir; R H Brown; Stephen W Scherer; Guy Rouleau; Michael R Hayden; Joh-E Ikeda
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Nature genetics 2001;29(2):166-73.
2001: Roshni R Singaraja; V Bocher; Erick R James; Susanne M Clee; Lin-Hua Zhang; Blair R Leavitt; B Tan; Angela R Brooks-Wilson; Anita Kwok; Nagat Bissada; Yu-Zhou Yang; Guoqing Liu; Sherrie R Tafuri; Catherine Fievet; Cheryl L Wellington; Bart Staels; Michael R Hayden
Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.
The Journal of biological chemistry 2001;276(36):33969-79.
2001: Elisabeth W Almqvist; D S Elterman; Patrick M MacLeod; Michael R Hayden
High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia.
Clinical genetics 2001;60(3):198-205.
2001: Jane S Paulsen; H Zhao; Julie C Stout; Ryan R Brinkman; Mark Guttman; Christopher A Ross; Peter G Como; C Manning; Michael R Hayden; Ira Shoulson
Clinical markers of early disease in persons near onset of Huntington's disease.
Neurology 2001;57(4):658-62.
2001: Chiara Zuccato; Andrea Ciammola; Dorotea Rigamonti; Blair R Leavitt; Donato Goffredo; Luciano Conti; Marcy E MacDonald; R M Friedlander; Vincenzo Silani; Michael R Hayden; Tõnis Timmusk; Simonetta Sipione; Elena Cattaneo
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
Science (New York, N.Y.) 2001;293(5529):493-8.
2001: Alyson Peel; Rammohan V Rao; Barbara A Cottrell; Michael R Hayden; Lisa M Ellerby; Dale E Bredesen
Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.
Human molecular genetics 2001;10(15):1531-8.
2001: Adam Rosenblatt; Ryan R Brinkman; Kung-Yee Liang; Elisabeth W Almqvist; Russell L Margolis; C Y Huang; M Sherr; ML Franz; Margaret H Abbott; Michael R Hayden; Christopher A Ross
Familial influence on age of onset among siblings with Huntington disease.
American journal of medical genetics 2001;105(5):399-403.
2001: Sandra H McGladdery; Simon Pimstone; Susanne M Clee; J F Bowden; Michael R Hayden; Jiri J Frohlich
Common mutations in the lipoprotein lipase gene (LPL): effects on HDL-cholesterol levels in a Chinese Canadian population.
Atherosclerosis 2001;156(2):401-7.
2001: Susanne M Clee; Aeilko H Zwinderman; J C Engert; Karin Zwarts; Henri O F Molhuizen; Kirsten Roomp; J Wouter Jukema; M van Wijland; Marjel J van Dam; T J Hudson; Angela R Brooks-Wilson; Jacques Genest; John J P Kastelein; Michael R Hayden
Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease.
Circulation 2001;103(9):1198-205.
2001: Robin Emsley; Dana J H Niehaus; N Irene Mbanga; Piet P Oosthuizen; Dan Stein; J Stephanus Maritz; Simon Pimstone; Michael R Hayden; Claudine Laurent; Jean-François Deleuze; Jacques Mallet
The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia.
Schizophrenia research 2001;47(2-3):149-57.
2001: Sébastien Holbert; I Denghien; T Kiechle; Adam Rosenblatt; Cheryl L Wellington; Michael R Hayden; Russell L Margolis; Christopher A Ross; Jean Dausset; Robert J Ferrante; Christian Néri
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1811-6.
2001: CJ Otto; Elisabeth W Almqvist; Michael R Hayden; Susan E Andrew
The "flap" endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease.
Clinical genetics 2001;59(2):122-7.
2001: D Falush; E W Almqvist; R R Brinkmann; Yoh Iwasa; Michael R Hayden
Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases.
American journal of human genetics 2001;68(2):373-85.
2001: Robert C Backus; DG Ginzinger; KJ Ashbourne-Excoffon; Susanne M Clee; Michael R Hayden; R H Eckel; M Anne Hickman; Quinton R Rogers
Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency.
American journal of veterinary research 2001;62(2):264-9.
2001: Blair R Leavitt; Julian A Guttman; JG Hodgson; Gil Kimel; Roshni R Singaraja; A Wayne Vogl; Michael R Hayden
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
American journal of human genetics 2001;68(2):313-24.
2001: Shinji Hadano; Yoshiko Yanagisawa; Jennifer Skaug; Keith Fichter; Jamal Nasir; Duane W Martindale; BF Koop; Stephen W Scherer; Donald W Nicholson; Guy Rouleau; J Ikeda; Michael R Hayden
Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.
Genomics 2001;71(2):200-13.
2001: Melinda M Zeron; Nansheng Chen; ali moshaver; A T Lee; Cheryl L Wellington; Michael R Hayden; Lynn A Raymond
Mutant huntingtin enhances excitotoxic cell death.
Molecular and cellular neurosciences 2001;17(1):41-53.
2000: Abigail S Hackam; A S Yassa; Roshni R Singaraja; Martina Metzler; Claire-Anne Gutekunst; Lu Gan; Simon Warby; Cheryl L Wellington; John P Vaillancourt; Nansheng Chen; François G Gervais; L Raymond; Donald W Nicholson; Michael R Hayden
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
The Journal of biological chemistry 2000;275(52):41299-308.
2000: Michael R Hayden
Predictive testing for Huntington's disease: the calm after the storm.
Lancet 2000;356(9246):1944-5.
2000: Debby W Tsuang; E W Almqvist; H Lipe; F Strgar; Lillian DiGiacomo; D Hoff; Charisma J Eugenio; Michael R Hayden; Thomas D Bird
Familial aggregation of psychotic symptoms in Huntington's disease.
The American journal of psychiatry 2000;157(12):1955-9.
2000: Susanne M Clee; John J P Kastelein; Marjel J van Dam; Michel Marcil; Kirsten Roomp; Karin Zwarts; JA Collins; R Roelants; N Tamasawa; Tomas Stulc; T Suda; R Ceska; Betsie Boucher; C Rondeau; C DeSouich; Angela R Brooks-Wilson; Henri O F Molhuizen; J Frohlich; Jacques Genest; Michael R Hayden
Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.
The Journal of clinical investigation 2000;106(10):1263-70.
2000: Vikramjit Chopra; Martina Metzler; Dita M Rasper; Asa E Y Engqvist-Goldstein; Roshni R Singaraja; Lu Gan; Keith Fichter; Krista McCutcheon; David G Drubin; Donald W Nicholson; Michael R Hayden
HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):1006-15.
2000: John J P Kastelein; J Wouter Jukema; Aeilko H Zwinderman; S Clee; Ad J van Boven; Hans Jansen; ton rabelink; Ron J G Peters; KI Lie; G Liu; A V G Bruschke; Michael R Hayden
Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group.
Circulation 2000;102(14):1629-33.
2000: Jamal Nasir; M J Lafuente; K Duan; Veronica F Colomer Gould; Simone Engelender; R Ingersoll; Russell L Margolis; Christopher A Ross; Michael R Hayden
Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.
Gene 2000;254(1-2):181-7.
2000: Geoff Clarke; R A Collins; Blair R Leavitt; D F Andrews; Michael R Hayden; Charles J Lumsden; Roderick R McInnes
A one-hit model of cell death in inherited neuronal degenerations.
Nature 2000;406(6792):195-9.
2000: Cheryl L Wellington; Roshni R Singaraja; Lisa M Ellerby; J Savill; Sophie Roy; Blair R Leavitt; Elena Cattaneo; Abigail S Hackam; A Sharp; N Thornberry; Donald W Nicholson; Dale E Bredesen; Michael R Hayden
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
The Journal of biological chemistry 2000;275(26):19831-8.
2000: Dorotea Rigamonti; Johannes Bauer; C De Fraja; Luciano Conti; Simonetta Sipione; Clara Sciorati; Emilio Clementi; Abigail S Hackam; Michael R Hayden; Yun Li; J K Cooper; Christopher A Ross; Stefano Govoni; Claudius Vincenz; Elena Cattaneo
Wild-type huntingtin protects from apoptosis upstream of caspase-3.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3705-13.
2000: Michael R Hayden; Susanne M Clee; Angela R Brooks-Wilson; Jacques Genest; Alan D Attie; John J P Kastelein
Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency.
Current opinion in lipidology 2000;11(2):117-22.
2000: Susanne M Clee; Nagat Bissada; Fudan Miao; L Miao; Adrian David Marais; Howard E Henderson; P Steures; J McManus; Bruce McManus; R C LeBoeuf; John J P Kastelein; Michael R Hayden
Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis.
Journal of lipid research 2000;41(4):521-31.
2000: Martina Metzler; Cheryl D Helgason; Ioannis Dragatsis; T Zhang; Lu Gan; Nicolas Pineault; Scott Zeitlin; R Keith Humphries; Michael R Hayden
Huntingtin is required for normal hematopoiesis.
Human molecular genetics 2000;9(3):387-94.
2000: Cheryl L Wellington; Blair R Leavitt; Michael R Hayden
Huntington disease: new insights on the role of huntingtin cleavage.
Journal of neural transmission. Supplementum 2000;(58):1-17.
2000: Cheryl L Wellington; Michael R Hayden
Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.
Clinical genetics 2000;57(1):1-10.
2000: Guoqing Liu; KJ Ashbourne-Excoffon; Janet E Wilson; Bruce M McManus; Quinton R Rogers; L Miao; John J P Kastelein; ME Lewis; Michael R Hayden
Phenotypic correction of feline lipoprotein lipase deficiency by adenoviral gene transfer.
Human gene therapy 2000;11(1):21-32.
1999: Asa E Y Engqvist-Goldstein; Michael kessels; Vikramjit Chopra; Michael R Hayden; David G Drubin
An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles.
The Journal of cell biology 1999;147(7):1503-18.
1999: ME Wittekoek; Etelka Moll; Simon Pimstone; Mieke D Trip; Peter J Lansberg; Joep C Defesche; J J van Doormaal; Michael R Hayden; John J P Kastelein
A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2708-13.
1999: Michel Marcil; Angela R Brooks-Wilson; Susanne M Clee; Kirsten Roomp; Lin-Hua Zhang; L Yu; JA Collins; Marjel J van Dam; Henri O F Molhuizen; O Loubster; B F Ouellette; Christoph Wilhelm Sensen; Keith Fichter; S Mott; Maxime Denis; Betsie Boucher; Simon Pimstone; Jacques Genest; John J P Kastelein; Michael R Hayden
Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux.
Lancet 1999;354(9187):1341-6.
1999: John J P Kastelein; Jose Ordovas; ME Wittekoek; Simon Pimstone; W F Wilson; SE Gagné; M G Larson; Ernst Schaefer; JM Boer; C Gerdes; Michael R Hayden
Two common mutations (D9N, N291S) in lipoprotein lipase: a cumulative analysis of their influence on plasma lipids and lipoproteins in men and women.
Clinical genetics 1999;56(4):297-305.
1999: B Kremer; CM Clark; Elisabeth W Almqvist; Lynn A Raymond; P Graf; Claudia Jacova; MM Mezei; M A Hardy; BJ Snow; W Martin; Michael R Hayden
Influence of lamotrigine on progression of early Huntington disease: a randomized clinical trial.
Neurology 1999;53(5):1000-11.
1999: Angela R Brooks-Wilson; Michel Marcil; Susanne M Clee; Lin-Hua Zhang; Kirsten Roomp; Marjel J van Dam; L Yu; Carl G Brewer; JA Collins; Henri O F Molhuizen; Odell Loubser; B F Ouelette; Keith Fichter; KJ Ashbourne-Excoffon; Christoph Wilhelm Sensen; S Scherer; S Mott; Maxime Denis; Duane W Martindale; J Frohlich; K Morgan; BF Koop; Simon Pimstone; John J P Kastelein; Jacques Genest; Michael R Hayden
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency.
Nature genetics 1999;22(4):336-45.
1999: Shinji Hadano; Jamal Nasir; K Nichol; Dita M Rasper; John P Vaillancourt; S W Sherer; B G Beatty; Joh-E Ikeda; Donald W Nicholson; Michael R Hayden
Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(7):757-60.
1999: Abigail S Hackam; JG Hodgson; Roshni R Singaraja; T Zhang; Lu Gan; Claire-Anne Gutekunst; Steven M Hersch; Michael R Hayden
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1047-55.
1999: SE Gagné; M G Larson; Simon Pimstone; Ernst Schaefer; John J P Kastelein; P W Wilson; Jose Ordovas; Michael R Hayden
A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study.
Clinical genetics 1999;55(6):450-4.
1999: JG Hodgson; N Agopyan; Claire-Anne Gutekunst; Blair R Leavitt; F LePiane; Roshni R Singaraja; Desmond J Smith; Nagat Bissada; Krista McCutcheon; Jamal Nasir; Laure Jamot; Xiao-Jiang Li; M E Stevens; E Rosemond; John C Roder; A G Phillips; E M Rubin; Steven M Hersch; Michael R Hayden
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Neuron 1999;23(1):181-92.
1999: Nansheng Chen; T Luo; Cheryl L Wellington; Martina Metzler; Krista McCutcheon; Michael R Hayden; Lynn A Raymond
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
Journal of neurochemistry 1999;72(5):1890-8.
1999: Elisabeth W Almqvist; M Bloch; Ryan R Brinkman; D Craufurd; Michael R Hayden
A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease.
American journal of human genetics 1999;64(5):1293-304.
1999: Howard E Henderson; John J P Kastelein; Aeilko H Zwinderman; E Gagné; J Wouter Jukema; PW Reymer; BE Groenemeyer; KI Lie; A V G Bruschke; Michael R Hayden; Hans Jansen
Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins.
Journal of lipid research 1999;40(4):735-43.
1999: Jamal Nasir; Alan Maclean; Simone Engelender; K Duan; Russell L Margolis; John Kleiderlein; Christopher A Ross; Michael R Hayden
Chromosomal localization of the Huntingtin associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):397-8.
1999: Lisa M Ellerby; RL Andrusiak; Cheryl L Wellington; Abigail S Hackam; Stephanie Propp; J D Wood; A H Sharp; Russell L Margolis; Christopher A Ross; Guy S Salvesen; Michael R Hayden; Dale E Bredesen
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
The Journal of biological chemistry 1999;274(13):8730-6.
1999: Ove Bruland; EW Almqvist; Y P Goldberg; Helge Boman; Michael R Hayden; Per M Knappskog
Accurate determination of the number of CAG repeats in the Huntington disease gene using a sequence-specific internal DNA standard.
Clinical genetics 1999;55(3):198-202.
1999: Martina Metzler; Nansheng Chen; C D Helgason; Graham Kyrenia Rona; K Nichol; Krista McCutcheon; Jamal Nasir; R K Humphries; Lynn A Raymond; Michael R Hayden
Life without huntingtin: normal differentiation into functional neurons.
Journal of neurochemistry 1999;72(3):1009-18.
1999: John R O'Kusky; Jamal Nasir; F Cicchetti; A Parent; Michael R Hayden
Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene.
Brain research 1999;818(2):468-79.
1999: Blair R Leavitt; Cheryl L Wellington; Michael R Hayden
Recent insights into the molecular pathogenesis of Huntington disease.
Seminars in neurology 1999;19(4):385-95.
1999: M Kim; J Velier; Kathryn O Chase; Genevieve Laforet; M A Kalchman; Michael R Hayden; L Won; A Heller; Neil Aronin; Marian DiFiglia
Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.
Neuroscience 1999;89(4):1159-67.
1999: DG Ginzinger; Susanne M Clee; J Dallongeville; ME Lewis; Howard E Henderson; E Bauje; Quinton R Rogers; D R Jensen; R H Eckel; Roger Dyer; Sheila M Innis; B Jones; Jean-Charles Fruchart; Michael R Hayden
Lipid and lipoprotein analysis of cats with lipoprotein lipase deficiency.
European journal of clinical investigation 1999;29(1):17-26.
1999: Shinji Hadano; K Nichol; Ryan R Brinkman; Jamal Nasir; Duane W Martindale; BF Koop; Donald W Nicholson; Stephen W Scherer; Joh-E Ikeda; Michael R Hayden
A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
Genomics 1999;55(1):106-12.
1999: Abigail S Hackam; Roshni R Singaraja; T Zhang; Lu Gan; Michael R Hayden
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
Human molecular genetics 1999;8(1):25-33.
1999: Lisa M Ellerby; Abigail S Hackam; Stephanie Propp; H Michael Ellerby; Shahrooz Rabizadeh; N R Cashman; Mark Trifiro; Leonard Pinsky; Cheryl L Wellington; Guy S Salvesen; Michael R Hayden; Dale E Bredesen
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
Journal of neurochemistry 1999;72(1):185-95.
1998: Michael R Hayden
In vitro and in vivo models for Huntington disease: lessons for the polyglutamine expansion disorders.
Pathologie-biologie 1998;46(9):695-6.
1998: Fengqing Xiang; E W Almqvist; M Huq; Anders Lundin; Michael R Hayden; Lars Edström; Maria Anvret; Z Zhang
A Huntington disease-like neurodegenerative disorder maps to chromosome 20p.
American journal of human genetics 1998;63(5):1431-8.
1998: Guoqing Liu; Katherine J D Ashbourne Excoffon; Janet E Wilson; Bruce M McManus; L Miao; Pierre Benoit; Nicolas Duverger; Didier Branellec; Patrice DENEFLE; Michael R Hayden; ME Lewis
Enhanced lipolysis in normal mice expressing liver-derived human lipoprotein lipase after adenoviral gene transfer.
Clinical and investigative medicine. Médecine clinique et experimentale 1998;21(4-5):172-85.
1998: Howard E Henderson; S M Bijvoet; marcel mannens; T Bruin; D W Erkelens; Michael R Hayden; John J P Kastelein
Ile225Thr loop mutation in the lipoprotein lipase (LPL) gene is a de novo event.
American journal of medical genetics 1998;78(4):313-6.
1998: Jamal Nasir; K Duan; K Nichol; Simone Engelender; Roxann Ashworth; Veronica F Colomer Gould; S Thomas; C M Disteche; Michael R Hayden; Christopher A Ross
Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(7):565-70.
1998: Abigail S Hackam; Roshni R Singaraja; Cheryl L Wellington; Martina Metzler; Krista McCutcheon; T Zhang; M Kalchman; Michael R Hayden
The influence of huntingtin protein size on nuclear localization and cellular toxicity.
The Journal of cell biology 1998;141(5):1097-105.
1998: Cheryl L Wellington; Lisa M Ellerby; Abigail S Hackam; Russell L Margolis; Mark Trifiro; Roshni R Singaraja; Krista McCutcheon; Guy S Salvesen; Stephanie Propp; M Bromm; K J Rowland; T Zhang; Dita M Rasper; Sophie Roy; N Thornberry; Leonard Pinsky; A Kakizuka; Christopher A Ross; Donald W Nicholson; Dale E Bredesen; Michael R Hayden
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
1998: Dita M Rasper; John P Vaillancourt; Shinji Hadano; Vicky Houtzager; I Seiden; S L Keen; Paul Tawa; Steven Xanthoudakis; Jamal Nasir; Duane W Martindale; BF Koop; EP Peterson; Nancy A Thornberry; J Huang; D P MacPherson; SC Black; Felicita Hornung; Michael J Lenardo; Michael R Hayden; Sophie Roy; Donald W Nicholson
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
Cell death and differentiation 1998;5(4):271-88.
1998: Abigail S Hackam; Cheryl L Wellington; Michael R Hayden
The fatal attraction of polyglutamine-containing proteins.
Clinical genetics 1998;53(4):233-42.
1998: ME Wittekoek; Simon Pimstone; PW Reymer; L Feuth; G J Botma; Joep C Defesche; M Prins; Michael R Hayden; John J P Kastelein
A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia.
Circulation 1998;97(8):729-35.
1998: Simon Pimstone; X M Sun; C du Souich; Jiri J Frohlich; Michael R Hayden; A K Soutar
Phenotypic variation in heterozygous familial hypercholesterolemia: a comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):309-15.
1998: Duane W Martindale; Abigail S Hackam; A Wieczorek; Lisa M Ellerby; Cheryl L Wellington; Krista McCutcheon; Roshni R Singaraja; P Kazemi-Esfarjani; Rebecca S Devon; Seung Kim; Dale E Bredesen; F Tufaro; Michael R Hayden
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.
Nature genetics 1998;18(2):150-4.
1998: Howard E Henderson; Felicity Leisegang; F Hassan; Michael R Hayden; Dianne J Marais
A novel Glu421Lys substitution in the lipoprotein lipase gene in pregnancy-induced hypertriglyceridemic pancreatitis.
Clinica chimica acta; international journal of clinical chemistry 1998;269(1):1-12.
1998: John J P Kastelein; BE Groenemeyer; D M Hallman; Howard E Henderson; PW Reymer; SE Gagné; Hans Jansen; jacob seidell; Daan Kromhout; J Wouter Jukema; A V G Bruschke; E Boerwinkle; Michael R Hayden
The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group.
Clinical genetics 1998;53(1):27-33.
1998: Pierre Julien; Claude Gagné; M R Murthy; G Lévesque; Sital Moorjani; François Cadelis; Michael R Hayden; Paul J Lupien
Dyslipidemias associated with heterozygous lipoprotein lipase mutations in the French-Canadian population.
Human mutation 1998;Suppl 1():S148-53.
1998: Luc Foubert; Jean Luc de Gennes; Pascale Benlian; J Truffert; L Miao; Michael R Hayden
Compound heterozygosity for frameshift mutations in the gene for lipoprotein lipase in a patient with early-onset chylomicronemia.
Human mutation 1998;Suppl 1():S141-4.
1997: L O Abdel-Wareth; Simon Pimstone; J P Lagarde; Alain Raisonnier; Pascale Benlian; Peter Pritchard; Michael R Hayden; Jiri J Frohlich
Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: identification of a unique haplotype of the apolipoprotein B-100 allele.
Atherosclerosis 1997;135(2):181-5.
1997: E Ehrenborg; Susanne M Clee; Simon Pimstone; PW Reymer; Pascale Benlian; CF Hoogendijk; H J Davis; Nagat Bissada; L Miao; SE Gagné; L J Greenberg; R Henry; Howard E Henderson; Jose Ordovas; Ernst Schaefer; John J P Kastelein; Maritha J Kotze; Michael R Hayden
Ethnic variation and in vivo effects of the -93t-->g promoter variant in the lipoprotein lipase gene.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2672-8.
1997: Katherine J D Ashbourne Excoffon; Guoqing Liu; L Miao; Janet E Wilson; Bruce M McManus; C F Semenkovich; T Coleman; Pierre Benoit; Nicolas Duverger; Didier Branellec; Patrice DENEFLE; Michael R Hayden; ME Lewis
Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2532-9.
1997: DG Ginzinger; Janet E Wilson; DM Redenbach; ME Lewis; Susanne M Clee; Katherine J D Ashbourne Excoffon; Quinton R Rogers; Michael R Hayden; Bruce M McManus
Diet-induced atherosclerosis in the domestic cat.
Laboratory investigation; a journal of technical methods and pathology 1997;77(5):409-19.
1997: S E Andrew; Y P Goldberg; Michael R Hayden
Rethinking genotype and phenotype correlations in polyglutamine expansion disorders.
Human molecular genetics 1997;6(12):2005-10.
1997: Elisabeth W Almqvist; S Adam; M Bloch; A Fuller; P Welch; D Eisenberg; D Whelan; D Macgregor; Wendy S Meschino; Michael R Hayden
Risk reversals in predictive testing for Huntington disease.
American journal of human genetics 1997;61(4):945-52.
1997: Susanne M Clee; H Zhang; Nagat Bissada; L Miao; E Ehrenborg; Pascale Benlian; Garry X Shen; A Angel; R C LeBoeuf; Michael R Hayden
Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: modulation by cholesteryl ester transfer protein and dietary status.
Journal of lipid research 1997;38(10):2079-89.
1997: Michael M Burgess; S Adam; M Bloch; Michael R Hayden
Dilemmas of anonymous predictive testing for Huntington disease: privacy vs. optimal care.
American journal of medical genetics 1997;71(2):197-201.
1997: Luc Foubert; Jean Luc de Gennes; JP Lagarde; E Ehrenborg; Alain Raisonnier; Jean-Philippe Girardet; Michael R Hayden; Pascale Benlian
Assessment of French patients with LPL deficiency for French Canadian mutations.
Journal of medical genetics 1997;34(8):672-5.
1997: Cheryl L Wellington; Michael R Hayden
Of molecular interactions, mice and mechanisms: new insights into Huntington's disease.
Current opinion in neurology 1997;10(4):291-8.
1997: Jamal Nasir; JL Theilmann; John P Vaillancourt; N A Munday; A Ali; S Scherer; B Beatty; Donald W Nicholson; Michael R Hayden
Interleukin-1beta-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(8):611-3.
1997: Cheryl L Wellington; R R Brinkman; J R O'Kusky; Michael R Hayden
Toward understanding the molecular pathology of Huntington's disease.
Brain pathology (Zurich, Switzerland) 1997;7(3):979-1002.
1997: B E Groenemeijer; M D Hallman; PW Reymer; E Gagné; Jan Albert Kuivenhoven; T Bruin; Hans Jansen; KI Lie; A V G Bruschke; E Boerwinkle; Michael R Hayden; John J P Kastelein
Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. REGRESS Study Group.
Circulation 1997;95(12):2628-35.
1997: Simon Pimstone; Joep C Defesche; Susanne M Clee; Henk D Bakker; Michael R Hayden; John J P Kastelein
Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(5):826-33.
1997: Ryan R Brinkman; MM Mezei; JL Theilmann; Elisabeth W Almqvist; Michael R Hayden
The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size.
American journal of human genetics 1997;60(5):1202-10.
1997: M A Kalchman; H B Koide; Krista McCutcheon; Graham Kyrenia Rona; K Nichol; K Nishiyama; P Kazemi-Esfarjani; Francis C Lynn; Cheryl L Wellington; Martina Metzler; Y Paul Goldberg; I Kanazawa; R D Gietz; Michael R Hayden
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.
Nature genetics 1997;16(1):44-53.
1997: GM Goellner; D Tester; S Thibodeau; EW Almqvist; Y Paul Goldberg; Michael R Hayden; Cynthia T McMurray
Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer.
American journal of human genetics 1997;60(4):879-90.
1997: Morten S Nielsen; J Brejning; R García; H Zhang; Michael R Hayden; S Vilaró; Jørgen Gliemann
Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans.
The Journal of biological chemistry 1997;272(9):5821-7.
1997: CM Clark; Claudia Jacova; H Klonoff; B Kremer; Michael R Hayden; D Paty
Pathological association and dissociation of functional systems in multiple sclerosis and Huntington's disease.
Journal of clinical and experimental neuropsychology 1997;19(1):63-76.
1997: Samuel S Chong; EW Almqvist; H Telenius; L LaTray; K Nichol; B Bourdelat-Parks; Y Paul Goldberg; B R Haddad; F Richards; D Sillence; C R Greenberg; E Ives; Ger van den Engh; M R Hughes; Michael R Hayden
Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington disease: evidence from single sperm analyses.
Human molecular genetics 1997;6(2):301-9.
1997: Guoqing Liu; Katherine J D Ashbourne Excoffon; Pierre Benoit; DG Ginzinger; L Miao; E Ehrenborg; Nicolas Duverger; Patrice DENEFLE; Michael R Hayden; ME Lewis
Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells.
Human gene therapy 1997;8(2):205-14.
1997: Luc Foubert; T Bruin; Jean Luc de Gennes; E Ehrenborg; J Furioli; John J P Kastelein; Pascale Benlian; Michael R Hayden
A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry.
Human mutation 1997;10(3):179-85.
1997: Jamal Nasir; JL Theilmann; Vikramjit Chopra; A M Jones; D Walker; Dita M Rasper; John P Vaillancourt; J E Hewitt; Donald W Nicholson; Michael R Hayden
Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(1):56-9.
1996: J G Hodgson; Desmond J Smith; Krista McCutcheon; H B Koide; K Nishiyama; M B Dinulos; M E Stevens; Nagat Bissada; Jamal Nasir; I Kanazawa; C M Disteche; Edward M Rubin; Michael R Hayden
Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype.
Human molecular genetics 1996;5(12):1875-85.
1996: S M Bijvoet; Heiko Wiebusch; Y Ma; PW Reymer; T Bruin; Henk D Bakker; Harald Funke; G Assmann; Michael R Hayden; John J P Kastelein
Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency.
The Netherlands journal of medicine 1996;49(5):189-95.
1996: J Wouter Jukema; Ad J van Boven; B Groenemeijer; A H Zwinderman; Johan H C Reiber; A V G Bruschke; J A Henneman; G P Molhoek; T Bruin; Hans Jansen; E Gagné; Michael R Hayden; John J P Kastelein
The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study.
Circulation 1996;94(8):1913-8.
1996: Howard E Henderson; F Hassan; Dianne J Marais; Michael R Hayden
A new mutation destroying disulphide bridging in the C-terminal domain of lipoprotein lipase.
Biochemical and biophysical research communications 1996;227(1):189-94.
1996: S Wiggins; T Green; S Adam; Michael R Hayden
A long term (ca 5 years) prospective assessment of psychological consequences of predictive testing for Huntington disease (HD)
American journal of human genetics 1996;59(4):A7.
1996: K Lawson; S Wiggins; T Green; S Adam; M Bloch; Michael R Hayden
Adverse psychological events occurring in the first year after predictive testing for Huntington's disease. The Canadian Collaborative Study Predictive Testing.
Journal of medical genetics 1996;33(10):856-62.
1996: Pascale Benlian; Jean Luc de Gennes; Luc Foubert; H Zhang; SE Gagné; Michael R Hayden
Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene.
The New England journal of medicine 1996;335(12):848-54.
1996: M A Kalchman; Graham Kyrenia Rona; G Xia; H B Koide; J G Hodgson; K C Graham; Y Paul Goldberg; R Daniel Gietz; Cecile M Pickart; Michael R Hayden
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.
The Journal of biological chemistry 1996;271(32):19385-94.
1996: JD Bagdade; M C Ritter; H Lithell; D Bassett; F Mailly; Philippa J Talmud; Michael R Hayden
Reduced cholesteryl ester transfer in plasma of patients with lipoprotein lipase deficiency.
Journal of lipid research 1996;37(8):1696-703.
1996: Simon Pimstone; Susanne M Clee; SE Gagné; L Miao; H Zhang; E A Stein; Michael R Hayden
A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers.
Journal of lipid research 1996;37(8):1675-84.
1996: Pascale Benlian; Luc Foubert; E Gagné; L Bernard; Jean Luc de Gennes; Sylvie Langlois; W Robinson; Michael R Hayden
Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency.
American journal of human genetics 1996;59(2):431-6.
1996: Y Paul Goldberg; Donald W Nicholson; Dita M Rasper; M A Kalchman; H B Koide; Graham Kyrenia Rona; M Bromm; P Kazemi-Esfarjani; Nancy A Thornberry; John P Vaillancourt; Michael R Hayden
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.
Nature genetics 1996;13(4):442-9.
1996: H Zhang; Howard E Henderson; S E Gagne; Susanne M Clee; L Miao; Guoqing Liu; Michael R Hayden
Common sequence variants of lipoprotein lipase: standardized studies of in vitro expression and catalytic function.
Biochimica et biophysica acta 1996;1302(2):159-66.
1996: David C Rubinsztein; J Leggo; R Coles; E Almqvist; V Biancalana; J J Cassiman; K Chotai; M Connarty; D Crauford; A Curtis; D Curtis; M J Davidson; A M Differ; C Dode; A Dodge; M Frontali; NG Ranen; O Colin Stine; M Sherr; Margaret H Abbott; ML Franz; C A Graham; P S Harper; J C Hedreen; Michael R Hayden
Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats.
American journal of human genetics 1996;59(1):16-22.
1996: F Squitieri; G Campanella; Michael R Hayden
Update on genetics of Huntington's disease: availability of direct and accurate predictive test.
Italian journal of neurological sciences 1996;17(3):185-7.
1996: Joep C Defesche; Denise Van Diermen; Michael R Hayden; J P Kastelein
Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia.
Gene geography : a computerized bulletin on human gene frequencies 1996;10(1):1-10.
1996: M M Burgess; Michael R Hayden
Patients' rights to laboratory data: trinucleotide repeat length in Huntington disease.
American journal of medical genetics 1996;62(1):6-9.
1996: S Bijvoet; SE Gagné; Sital Moorjani; Claude Gagné; Howard E Henderson; J C Fruchart; J Dallongeville; P Alaupovic; M Prins; John J P Kastelein; Michael R Hayden
Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency.
Journal of lipid research 1996;37(3):640-50.
1996: Y Paul Goldberg; M A Kalchman; Martina Metzler; Jamal Nasir; J Zeisler; Graham Kyrenia Rona; H B Koide; John R O'Kusky; A H Sharp; Christopher A Ross; Frank R Jirik; Michael R Hayden
Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript.
Human molecular genetics 1996;5(2):177-85.
1996: Jamal Nasir; Y Paul Goldberg; Michael R Hayden
Huntington disease: new insights into the relationship between CAG expansion and disease.
Human molecular genetics 1996;5 Spec No():1431-5.
1995: A Krapp; H Zhang; DG Ginzinger; M S Liu; A Lindberg; Gunilla Olivecrona; Michael R Hayden; Ulrike Beisiegel
Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells.
Journal of lipid research 1995;36(11):2362-73.
1995: Y Paul Goldberg; Cynthia T McMurray; J Zeisler; Elisabeth W Almqvist; D Sillence; F Richards; AM Gacy; J Buchanan; H Telenius; Michael R Hayden
Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population.
Human molecular genetics 1995;4(10):1911-8.
1995: H Zhang; PW Reymer; M S Liu; I J Forsythe; B E Groenemeyer; J Frohlich; J D Brunzell; John J P Kastelein; Michael R Hayden; Y Ma
Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291-->Ser mutation in the human LPL gene.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1695-703.
1995: S E Andrew; Michael R Hayden
Origins and evolution of Huntington disease chromosomes.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1995;4(3):239-44.
1995: B Kremer; Elisabeth W Almqvist; J Theilmann; N Spence; H Telenius; Y Paul Goldberg; Michael R Hayden
Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes.
American journal of human genetics 1995;57(2):343-50.
1995: Tobin Copley; S Wiggins; S Dufrasne; M Bloch; S Adam; W McKellin; Michael R Hayden
Are we all of one mind? Clinicians' and patients' opinions regarding the development of a service protocol for predictive testing for Huntington disease. Canadian Collaborative Study for Predictive Testing for Huntington Disease.
American journal of medical genetics 1995;58(1):59-69.
1995: ME Lewis; I J Forsythe; Jamey D Marth; J D Brunzell; Michael R Hayden; R Keith Humphries
Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells.
Human gene therapy 1995;6(7):853-63.
1995: Jamal Nasir; Stan B Floresco; John R O'Kusky; V M Diewert; Joy M Richman; J Zeisler; A Borowski; Jamey D Marth; Anthony G Phillips; Michael R Hayden
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
Cell 1995;81(5):811-23.
1995: Peter C K Leung; J Squire; C Peng; N Fan; Michael R Hayden; Jan Olofsson
Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(4):309-10.
1995: J W Britton; Ryan Uitti; J Eric Ahlskog; R G Robinson; B Kremer; Michael R Hayden
Hereditary late-onset chorea without significant dementia: genetic evidence for substantial phenotypic variation in Huntington's disease.
Neurology 1995;45(3 Pt 1):443-7.
1995: B Lin; Jamal Nasir; M A Kalchman; H McDonald; J Zeisler; Y Paul Goldberg; Michael R Hayden
Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms.
Genomics 1995;25(3):707-15.
1995: Michael R Hayden; M Bloch; S Wiggins
Psychological effects of predictive testing for Huntington's disease.
Advances in neurology 1995;65():201-10.
1995: B Lin; Jamal Nasir; H McDonald; Graham Kyrenia Rona; Johanna M Rommens; Y Paul Goldberg; Michael R Hayden
Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms.
Genomics 1995;25(1):93-9.
1995: Michael R Hayden; M Reidy
Many roads lead to atheroma.
Nature medicine 1995;1(1):22-3.
1994: Lorne A Clarke; Jamal Nasir; H Zhang; H McDonald; Derek A Applegarth; Michael R Hayden; Jennifer R Toone
Murine alpha-L-iduronidase: cDNA isolation and expression.
Genomics 1994;24(2):311-6.
1994: H Shinotoh; Donald B Calne; B Snow; M Hayward; B Kremer; J Theilmann; Michael R Hayden
Normal CAG repeat length in the Huntington's disease gene in senile chorea.
Neurology 1994;44(11):2183-4.
1994: Y Ma; Howard E Henderson; M S Liu; H Zhang; I J Forsythe; I Clarke-Lewis; Michael R Hayden; J D Brunzell
Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase.
Journal of lipid research 1994;35(11):2049-59.
1994: E Gagné; J Genest; H Zhang; Lorne A Clarke; Michael R Hayden
Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1250-7.
1994: Elisabeth W Almqvist; S Andrew; J Theilmann; P Goldberg; J Zeisler; U Drugge; U Grandell; M Tapper-Persson; Bengt Winblad; Michael R Hayden
Geographical distribution of haplotypes in Swedish families with Huntington's disease.
Human genetics 1994;94(2):124-8.
1994: Y Paul Goldberg; H Telenius; Michael R Hayden
The molecular genetics of Huntington's disease.
Current opinion in neurology 1994;7(4):325-32.
1994: S Tuzgöl; S M Bijvoet; T Bruin; John J P Kastelein; Michael R Hayden
Apolipoprotein CII-Padova (Tyr37-->stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana.
Journal of medical genetics 1994;31(8):622-6.
1994: Michael R Hayden; M S Liu; Y Ma
Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase.
Clinical genetics 1994;46(1 Spec No):15-8.
1994: Jamal Nasir; B Lin; M Bucan; T Koizumi; J H Nadeau; Michael R Hayden
The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3.
Genomics 1994;22(1):198-201.
1994: Y Ma; T C Ooi; M S Liu; H Zhang; R McPherson; A L Edwards; I J Forsythe; Jiri Frohlich; J D Brunzell; Michael R Hayden
High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: possible association with apolipoprotein E2 isoform.
Journal of lipid research 1994;35(6):1066-75.
1994: S M Bijvoet; T Bruin; S Tuzgöl; Henk D Bakker; Michael R Hayden; John J P Kastelein
Homozygosity for a mutation in the lipoprotein lipase gene (Gly139-->Ser) causes chylomicronaemia in a boy of Spanish descent.
Human genetics 1994;93(3):339-43.
1994: T Bruin; S Tuzgöl; W J Mulder; A E van den Ende; Hans Jansen; Michael R Hayden; John J P Kastelein
A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression.
Journal of lipid research 1994;35(3):438-45.
1994: J Davignon; G Roederer; M Montigny; Michael R Hayden; Meng Tan; P W Connelly; R Hegele; R McPherson; P J Lupien; Claude Gagné
Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia.
The American journal of cardiology 1994;73(5):339-45.
1994: Olaf Riess; U Thies; I Siedlaczck; S Potisek; Graham Kyrenia Rona; J Theilmann; T Grimm; J T Epplen; Michael R Hayden
Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16.
Genomics 1994;19(2):298-302.
1994: B Lin; Jamal Nasir; H MacDonald; G Hutchinson; Graham Kyrenia Rona; Johanna M Rommens; Michael R Hayden
Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat [corrected].
Human molecular genetics 1994;3(1):85-92.
1994: S E Andrew; Y Paul Goldberg; J Theilmann; J Zeisler; Michael R Hayden
A CCG repeat polymorphism adjacent to the CAG repeat in the Huntington disease gene: implications for diagnostic accuracy and predictive testing.
Human molecular genetics 1994;3(1):65-7.
1994: H Karlinsky; A D Sadovnick; Michael M Burgess; S Langlois; Michael R Hayden; J M Berg
Issues in molecular genetic testing of individuals with suspected early-onset familial Alzheimer's disease.
Alzheimer disease and associated disorders 1994;8(2):116-25.
1993: T Bruin; S Tuzgöl; Denise Van Diermen; N Hoogerbrugge-van der Linden; J D Brunzell; Michael R Hayden; John J P Kastelein
Recurrent pancreatitis and chylomicronemia in an extended Dutch kindred is caused by a Gly154-->Ser substitution in lipoprotein lipase.
Journal of lipid research 1993;34(12):2109-19.
1993: B Kremer; F Squitieri; H Telenius; S E Andrew; J Theilmann; N Spence; Y Paul Goldberg; Michael R Hayden
Molecular analysis of late onset Huntington's disease.
Journal of medical genetics 1993;30(12):991-5.
1993: Y Paul Goldberg; S E Andrew; J Theilmann; B Kremer; F Squitieri; H Telenius; J D Brown; Michael R Hayden
Familial predisposition to recurrent mutations causing Huntington's disease: genetic risk to sibs of sporadic cases.
Journal of medical genetics 1993;30(12):987-90.
1993: Joep C Defesche; Denise Van Diermen; P J Lansberg; R J Lamping; PW Reymer; Michael R Hayden; John J P Kastelein
South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population.
Human genetics 1993;92(6):567-70.
1993: R Babul; S Adam; B Kremer; S Dufrasne; S Wiggins; M Huggins; J Theilmann; M Bloch; Michael R Hayden
Attitudes toward direct predictive testing for the Huntington disease gene. Relevance for other adult-onset disorders. The Canadian Collaborative Group on Predictive Testing for Huntington Disease.
JAMA : the journal of the American Medical Association 1993;270(19):2321-5.
1993: Joep C Defesche; K L Pricker; Michael R Hayden; B E van der Ende; John J P Kastelein
Familial defective apolipoprotein B-100 is clinically indistinguishable from familial hypercholesterolemia.
Archives of internal medicine 1993;153(20):2349-56.
1993: B Lin; Johanna M Rommens; Graham Kyrenia Rona; M Kalchman; H MacDonald; Jamal Nasir; A Delaney; Y Paul Goldberg; Michael R Hayden
Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression.
Human molecular genetics 1993;2(10):1541-5.
1993: Michael R Hayden; R Josephson
Development of a program for identification of patients with familial hypercholesterolemia in British Columbia: a model for prevention of coronary disease.
The American journal of cardiology 1993;72(10):25D-29D.
1993: Howard E Henderson; Y Ma; M S Liu; I Clark-Lewis; Dennis L Maeder; John J P Kastelein; J D Brunzell; Michael R Hayden
Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region.
Journal of lipid research 1993;34(9):1593-602.
1993: M Bloch; S Adam; A Fuller; B Kremer; J P Welch; S Wiggins; P Whyte; M Huggins; J Theilmann; Michael R Hayden
Diagnosis of Huntington disease: a model for the stages of psychological response based on experience of a predictive testing program.
American journal of medical genetics 1993;47(3):368-74.
1993: G B Hutchinson; S E Andrew; H McDonald; Y Paul Goldberg; Graham Kyrenia Rona; Johanna M Rommens; Michael R Hayden
An Alu element retroposition in two families with Huntington disease defines a new active Alu subfamily.
Nucleic acids research 1993;21(15):3379-83.
1993: C Collins; C Duff; AM Duncan; Rosa Planells-Cases; W Sun; A Norremolle; E Michaelis; Mauricio Montal; R Worton; Michael R Hayden
Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively.
Genomics 1993;17(1):237-9.
1993: Y Ma; M S Liu; H Zhang; I J Forsythe; J D Brunzell; Michael R Hayden
A 4 basepair deletion in exon 4 of the human lipoprotein lipase gene results in type I hyperlipoproteinemia.
Human molecular genetics 1993;2(7):1049-50.
1993: B Weber; Olaf Riess; H Daneshvar; Graham Kyrenia Rona; Michael R Hayden
(CA)n-dinucleotide repeat at the PDEB locus in 4p16.3.
Human molecular genetics 1993;2(6):827.
1993: S Andrew; J Theilmann; Elisabeth W Almqvist; A Norremolle; G Lucotte; Maria Anvret; S A Sorensen; J C Turpin; Michael R Hayden
DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease.
Clinical genetics 1993;43(6):286-94.
1993: Y Paul Goldberg; S E Andrew; Lorne A Clarke; Michael R Hayden
A PCR method for accurate assessment of trinucleotide repeat expansion in Huntington disease.
Human molecular genetics 1993;2(6):635-6.
1993: Y Ma; M S Liu; DG Ginzinger; Jiri Frohlich; J D Brunzell; Michael R Hayden
Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene.
The Journal of clinical investigation 1993;91(5):1953-8.
1993: Michael R Hayden
On planting alfalfa and growing orchids: the cloning of the gene causing Huntington disease.
Clinical genetics 1993;43(5):217-22.
1993: Michael R Hayden; John J P Kastelein; Harald Funke; J D Brunzell; Y Ma
Phenotypic variation of mutations in the human lipoprotein-lipase gene.
Biochemical Society transactions 1993;21(2):506-9.
1993: N Durbach; Michael R Hayden
George Huntington: the man behind the eponym.
Journal of medical genetics 1993;30(5):406-9.
1993: S Wood; Mike Schertzer; Michael R Hayden; Y Ma
Support for founder effect for two lipoprotein lipase (LPL) gene mutations in French Canadians by analysis of GT microsatellites flanking the LPL gene.
Human genetics 1993;91(4):312-6.
1993: A Zambon; A Torres; S Bijvoet; C Gagne; Sital Moorjani; Paul J Lupien; Michael R Hayden; J D Brunzell
Prevention of raised low-density lipoprotein cholesterol in a patient with familial hypercholesterolaemia and lipoprotein lipase deficiency.
Lancet 1993;341(8853):1119-21.
1993: I Tooyama; H P Kremer; Michael R Hayden; H Kimura; Edith G McGeer; Patrick L McGeer
Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease.
Brain research 1993;610(1):1-7.
1993: Edith G McGeer; B Kremer; Michael R Hayden
Monoamines and their metabolites in Huntington's disease brain: evidence for decreased catechol-O-methyltransferase activity.
Biological psychiatry 1993;33(7):551-3.
1992: Joep C Defesche; M A van de Ree; John J P Kastelein; Denise Van Diermen; N W Janssens; J J van Doormaal; Michael R Hayden
Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada.
Clinical genetics 1992;42(6):273-80.
1992: C Collins; K Schappert; Michael R Hayden
The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates.
Human molecular genetics 1992;1(9):727-33.
1992: S Wiggins; P Whyte; M Huggins; S Adam; J Theilmann; M Bloch; Sam Sheps; Martin T Schechter; Michael R Hayden
The psychological consequences of predictive testing for Huntington's disease. Canadian Collaborative Study of Predictive Testing.
The New England journal of medicine 1992;327(20):1401-5.
1992: B Weber; Olaf Riess; G Wolff; S Andrew; C Collins; Graham Kyrenia Rona; J Theilmann; Michael R Hayden
Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.
Nature genetics 1992;2(3):216-22.
1992: B Kremer; B Weber; Michael R Hayden
New insights into the clinical features, pathogenesis and molecular genetics of Huntington disease.
Brain pathology (Zurich, Switzerland) 1992;2(4):321-35.
1992: Olaf Riess; A Noerremoelle; B Weber; Maria A Musarella; Michael R Hayden
The search for mutations in the gene for the beta subunit of the cGMP phosphodiesterase (PDEB) in patients with autosomal recessive retinitis pigmentosa.
American journal of human genetics 1992;51(4):755-62.
1992: S M Bijvoet; Michael R Hayden
Mismatch PCR: a rapid method to screen for the Pro207-->Leu mutation in the lipoprotein lipase (LPL) gene.
Human molecular genetics 1992;1(7):541.
1992: M S Liu; Y Ma; Michael R Hayden; J D Brunzell
Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activity.
Biochimica et biophysica acta 1992;1128(1):113-5.
1992: T Bruin; John J P Kastelein; Denise Van Diermen; Y Ma; Howard E Henderson; P M Stuyt; A F Stalenhoef; Augueste Sturk; J D Brunzell; Michael R Hayden
A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity.
European journal of biochemistry / FEBS 1992;208(2):267-72.
1992: Olaf Riess; B Weber; Michael R Hayden
(CA)n-dinucleotide repeat polymorphism at the locus for the alpha2C adrenergic receptor (ADRA2C) on 4p16.
Human molecular genetics 1992;1(6):452.
1992: Michael R Hayden; Y Ma
Molecular genetics of human lipoprotein lipase deficiency.
Molecular and cellular biochemistry 1992;113(2):171-6.
1992: G B Hutchinson; Michael R Hayden
The prediction of exons through an analysis of spliceable open reading frames.
Nucleic acids research 1992;20(13):3453-62.
1992: C Collins; G Hutchinson; D Kowbel; Olaf Riess; B Weber; Michael R Hayden
The human beta-subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal cDNA sequence and evidence for expression in brain.
Genomics 1992;13(3):698-704.
1992: S Andrew; J Theilmann; A Hedrick; D Mah; B Weber; Michael R Hayden
Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.
Genomics 1992;13(2):301-11.
1992: Olaf Riess; A Noerremoelle; C Collins; D Mah; B Weber; Michael R Hayden
Exclusion of DNA changes in the beta-subunit of the c-GMP phosphodiesterase gene as the cause for Huntington's disease.
Nature genetics 1992;1(2):104-8.
1992: Jean Bergeron; T Normand; A Bharucha; M R Ven Murthy; Pierre Julien; Claude Gagné; C Dionne; M De Braekeleer; D Brun; Michael R Hayden
Prevalence, geographical distribution and genealogical investigations of mutation 188 of lipoprotein lipase gene in the French Canadian population of Québec.
Clinical genetics 1992;41(4):206-10.
1992: M Huggins; Michael R Hayden
Predictive testing for Huntington disease.
Journal of medical ethics 1992;18(1):47-8.
1992: M Bloch; S Adam; S Wiggins; M Huggins; Michael R Hayden
Predictive testing for Huntington disease in Canada: the experience of those receiving an increased risk.
American journal of medical genetics 1992;42(4):499-507.
1992: Howard E Henderson; F Hassan; G M Berger; Michael R Hayden
The lipoprotein lipase Gly188----Glu mutation in South Africans of Indian descent: evidence suggesting common origins and an increased frequency.
Journal of medical genetics 1992;29(2):119-22.
1992: B Weber; A Hedrick; S Andrew; Olaf Riess; C Collins; D Kowbel; Michael R Hayden
Isolation and characterization of new highly polymorphic DNA markers from the Huntington disease region.
American journal of human genetics 1992;50(2):382-93.
1992: Y H Ma; T Bruin; S Tuzgol; B I Wilson; G Roederer; M S Liu; J Davignon; John J P Kastelein; J D Brunzell; Michael R Hayden
Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis.
The Journal of biological chemistry 1992;267(3):1918-23.
1992: W R Wayne Martin; C Clark; W Ammann; A Jon Stoessl; W Shtybel; Michael R Hayden
Cortical glucose metabolism in Huntington's disease.
Neurology 1992;42(1):223-9.
1992: C Dionne; Claude Gagné; Pierre Julien; M R Murthy; M Lambert; G Roederer; J Davignon; Michael R Hayden; P J Lupien; Marc de Braekeleer
Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Québec, Canada).
Annales de génétique 1992;35(2):89-92.
1992: Olaf Riess; B Weber; A Noeremolle; R A Shaikh; Michael R Hayden; Maria A Musarella
Linkage studies and mutation analysis of the PDEB gene in 23 families with Leber congenital amaurosis.
Human mutation 1992;1(6):478-85.
1991: B Weber; C Collins; D Kowbel; Olaf Riess; Michael R Hayden
Identification of multiple CpG islands and associated conserved sequences in a candidate region for the Huntington disease gene.
Genomics 1991;11(4):1113-24.
1991: B Weber; Olaf Riess; G Hutchinson; C Collins; B Y Lin; D Kowbel; S Andrew; K Schappert; Michael R Hayden
Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3.
Nucleic acids research 1991;19(22):6263-8.
1991: L J Greenberg; R W Martell; J Theilman; Michael R Hayden; J Joubert
Genetic linkage between Huntington disease and the D4S10 locus in South African families: further evidence against non-allelic heterogeneity.
Human genetics 1991;87(6):701-8.
1991: Michael R Hayden
Predictive testing for Huntington disease: are we ready for widespread community implementation?
American journal of medical genetics 1991;40(4):515-7.
1991: Howard E Henderson; Y Ma; M F Hassan; Maria Victoria Monsalve; A D Marais; F Winkler; K Gubernator; J Peterson; J D Brunzell; Michael R Hayden
Amino acid substitution (Ile194----Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands. Support for a multicentric origin.
The Journal of clinical investigation 1991;87(6):2005-11.
1991: B Weber; Olaf Riess; C N Kreklywich; S Wood; Michael R Hayden
A polymorphic DNA marker at the D8S131 locus.
Nucleic acids research 1991;19(7):1725.
1991: B Weber; Olaf Riess; Michael R Hayden
A polymorphic DNA marker at the D10S106 locus.
Nucleic acids research 1991;19(7):1725.
1991: J S Hill; Michael R Hayden; J Frohlich; P Haydn Pritchard
Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(2):290-7.
1991: C M Clark; W Ammann; W R Wayne Martin; P Ty; Michael R Hayden
The FDG/PET methodology for early detection of disease onset: a statistical model.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(2):A96-102.
1991: S Adam; J Theilmann; K Buetow; A Hedrick; C Collins; B Weber; M Huggins; Michael R Hayden
Linkage disequilibrium and modification of risk for Huntington disease.
American journal of human genetics 1991;48(3):595-603.
1991: B Weber; L Allen; R Ellen Magenis; Paul J Goodfellow; L Smith; Michael R Hayden
Intrachromosomal location of the telomeric repeat (TTAGGG)n.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):211-6.
1991: B Weber; L Allen; R Ellen Magenis; Michael R Hayden
A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini.
Cytogenetics and cell genetics 1991;57(4):179-83.
1990: Howard E Henderson; R Devlin; J Peterson; J D Brunzell; Michael R Hayden
Frameshift mutation in exon 3 of the lipoprotein lipase gene causes a premature stop codon and lipoprotein lipase deficiency.
Molecular biology & medicine 1990;7(6):511-7.
1990: L N Peritz; J D Brunzell; C Harvey-Clarke; P Haydn Pritchard; B R Jones; Michael R Hayden
Characterization of a lipoprotein lipase class III type defect in hypertriglyceridemic cats.
Clinical and investigative medicine. Médecine clinique et experimentale 1990;13(5):259-63.
1990: M Huggins; M Bloch; S Kanani; O W Quarrell; J Theilman; A Hedrick; B Dickens; A Lynch; Michael R Hayden
Ethical and legal dilemmas arising during predictive testing for adult-onset disease: the experience of Huntington disease.
American journal of human genetics 1990;47(1):4-12.
1990: B Weber; C Collins; C Robbins; R Ellen Magenis; A D Delaney; Joe Gray; Michael R Hayden
Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n.
Nucleic acids research 1990;18(11):3353-61.
1990: C Clark; H Klonoff; Michael R Hayden
Regional cerebral glucose metabolism in Turner syndrome.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1990;17(2):140-4.
1990: M Bloch; Michael R Hayden
DNA testing for Huntington disease results in a modification of risk and not diagnosis of disease.
European journal of pediatrics 1990;149(7):513.
1990: John J P Kastelein; Jonathan L Haines; Michael R Hayden
The gene causing familial hypoalphalipoproteinemia is not caused by a defect in the apo AI-CIII-AIV gene cluster in a Spanish family.
Human genetics 1990;84(5):396-400.
1990: Robert H Devlin; S Deeb; J Brunzell; Michael R Hayden
Partial gene duplication involving exon-Alu interchange results in lipoprotein lipase deficiency.
American journal of human genetics 1990;46(1):112-9.
1990: M Bloch; Michael R Hayden
Opinion: predictive testing for Huntington disease in childhood: challenges and implications.
American journal of human genetics 1990;46(1):1-4.
1989: Andrew Eisen; S Bohlega; M Bloch; Michael R Hayden
Silent periods, long-latency reflexes and cortical MEPs in Huntington's disease and at-risk relatives.
Electroencephalography and clinical neurophysiology 1989;74(6):444-9.
1989: J L Theilmann; C A Robbins; Michael R Hayden
Methylation at the D4S95 locus and predictive testing.
American journal of human genetics 1989;45(3):477-9.
1989: Michael R Hayden
The genetic aspects of atherosclerosis and hyperlipidemia.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1989;141(2):135.
1989: R B Lowry; B J Wood; T A Cox; Michael R Hayden
Epiphyseal dysplasia, microcephaly, nystagmus, and retinitis pigmentosa.
American journal of medical genetics 1989;33(3):341-5.
1989: M Fahy; C Robbins; M Bloch; R W Turnell; Michael R Hayden
Different options for prenatal testing for Huntington's disease using DNA probes.
Journal of medical genetics 1989;26(6):353-7.
1989: D Chitayat; E B Davis; B C McGillivray; Michael R Hayden; J G Hall
Perinatal and first year follow-up of patients with Prader-Willi syndrome: normal size of hands and feet.
Clinical genetics 1989;35(3):161-6.
1989: C Robbins; J Theilmann; S Youngman; Jonathan L Haines; M J Altherr; Peter S Harper; C Payne; A Junker; J Wasmuth; Michael R Hayden
Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.
American journal of human genetics 1989;44(3):422-5.
1989: Sylvie Langlois; S Deeb; J D Brunzell; John J P Kastelein; Michael R Hayden
A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):948-52.
1989: M Bloch; M Fahy; S Fox; Michael R Hayden
Predictive testing for Huntington disease: II. Demographic characteristics, life-style patterns, attitudes, and psychosocial assessments of the first fifty-one test candidates.
American journal of medical genetics 1989;32(2):217-24.
1989: S Fox; M Bloch; M Fahy; Michael R Hayden
Predictive testing for Huntington disease: I. Description of a pilot project in British Columbia.
American journal of medical genetics 1989;32(2):211-6.
1988: Michael R Hayden; C Robbins; D Allard; Jonathan L Haines; S Fox; J Wasmuth; M Fahy; M Bloch
Improved predictive testing for Huntington disease by using three linked DNA markers.
American journal of human genetics 1988;43(5):689-94.
1988: Raymond Lam; M Bloch; B D Jones; A M Marcus; S Fox; W Amman; Michael R Hayden
Psychiatric morbidity associated with early clinical diagnosis of Huntington disease in a predictive testing program.
The Journal of clinical psychiatry 1988;49(11):444-7.
1988: S W Rabkin; Michael R Hayden; Jiri Frohlich
Comparison of gemfibrozil and clofibrate on serum lipids in familial combined hyperlipidemia. A randomized placebo-controlled, double-blind, crossover clinical trial.
Atherosclerosis 1988;73(2-3):233-40.
1988: Michael R Hayden; M Bloch; M Fahy
Predictive testing for Huntington's disease using linked DNA markers.
The New England journal of medicine 1988;319(9):583-4.
1988: G W Jason; E M Pajurkova; Oksana Suchowersky; J Hewitt; C Hilbert; J Reed; Michael R Hayden
Presymptomatic neuropsychological impairment in Huntington's disease.
Archives of neurology 1988;45(7):769-73.
1988: Sylvie Langlois; John J P Kastelein; Michael R Hayden
Characterization of six partial deletions in the low-density-lipoprotein (LDL) receptor gene causing familial hypercholesterolemia (FH).
American journal of human genetics 1988;43(1):60-8.
1988: D Chitayat; A Lao; R D Wilson; C Fagerstrom; Michael R Hayden
Prenatal diagnosis of asplenia/polysplenia syndrome.
American journal of obstetrics and gynecology 1988;158(5):1085-7.
1988: JJ Wasmuth; J Hewitt; B Smith; D Allard; Jonathan L Haines; Douglas W Skarecky; E Partlow; Michael R Hayden
A highly polymorphic locus very tightly linked to the Huntington's disease gene.
Nature 1988;332(6166):734-6.
1988: Michael R Hayden; J Hewitt; J J Wasmuth; John J P Kastelein; Sylvie Langlois; M Conneally; Jonathan L Haines; B Smith; C Hilbert; D Allard
A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene.
American journal of human genetics 1988;42(1):125-31.
1987: Michael R Hayden; M Bloch; S Fox; D Crauford
Ethical issues in preclinical testing in Huntington disease: response to Margery Shaw's invited editorial comment.
American journal of medical genetics 1987;28(3):761-3.
1987: Jiri Frohlich; B Fong; P Julien; J P Despres; A Angel; Michael R Hayden; R McLeod; C Chow; R H Davison; H Pritchard
Interaction of high density lipoprotein with adipocytes in a new patient with Tangier disease.
Clinical and investigative medicine. Médecine clinique et experimentale 1987;10(5):377-82.
1987: Michael R Hayden; J Hewitt; A Jon Stoessl; C Clark; W Ammann; W R Wayne Martin
The combined use of positron emission tomography and DNA polymorphisms for preclinical detection of Huntington's disease.
Neurology 1987;37(9):1441-7.
1987: Marcy E MacDonald; M A Anderson; T C Gilliam; L Tranejaerg; N J Carpenter; E Magenis; Michael R Hayden; S T Healey; T I Bonner; James Gusella
A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene.
Genomics 1987;1(1):29-34.
1987: W R Wayne Martin; Michael R Hayden
Cerebral glucose and dopa metabolism in movement disorders.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1987;14(3 Suppl):448-51.
1987: M Bloch; Michael R Hayden
Preclinical testing in Huntington disease.
American journal of medical genetics 1987;27(3):733-4.
1987: Michael R Hayden; J Goldblatt; G Wallis; I M Winship; P Beighton
Molecular genetics and Huntington's disease. The South African situation.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1987;71(11):683-6.
1987: Michael R Hayden; J Hewitt; J J Kastelein; S Langlois; R D Wilson; S Fox; C Hilbert; M Bloch
First-trimester prenatal diagnosis for Huntington's disease with DNA probes.
Lancet 1987;1(8545):1284-5.
1986: C M Clark; Michael R Hayden; A Jon Stoessl; W R Martin
Regression model for predicting dissociations of regional cerebral glucose metabolism in individuals at risk for Huntington's disease.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1986;6(6):756-62.
1986: Thomas D Bird; J Hewitt; P M Conneally; Michael R Hayden
Linkage of the G8 marker on chromosome 4 to Huntington's disease in a large American black family.
The New England journal of medicine 1986;315(18):1165-6.
1986: H S Wang; C R Greenberg; J Hewitt; D Kalousek; Michael R Hayden
Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3.
American journal of human genetics 1986;39(3):392-6.
1986: Michael R Hayden; W R Wayne Martin; A Jon Stoessl; C Clark; S Hollenberg; M J Adam; W Ammann; R Harrop; J Rogers; Thomas J Ruth
Positron emission tomography in the early diagnosis of Huntington's disease.
Neurology 1986;36(7):888-94.
1986: U G Froster-Iskenius; Michael R Hayden; H S Wang; D K Kalousek; D Horsman; R A Pfeiffer; A Schottky; E Schwinger
A family with Huntington disease and reciprocal translocation 4;5.
American journal of human genetics 1986;38(5):759-67.
1986: J D Brunzell; P H Iverius; M S Scheibel; W Y Fujimoto; Michael R Hayden; R McLeod; J Frolich
Primary lipoprotein lipase deficiency.
Advances in experimental medicine and biology 1986;201():227-39.
1986: Oksana Suchowersky; Michael R Hayden; W R Wayne Martin; A Jon Stoessl; A M Hildebrand; B D Pate
Cerebral metabolism of glucose in benign hereditary chorea.
Movement disorders : official journal of the Movement Disorder Society 1986;1(1):33-44.
1985: James Gusella; Rudolph E Tanzi; P I Bader; M C Phelan; R Stevenson; Michael R Hayden; K J Hofman; A G Faryniarz; K Gibbons
Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.
Nature 1985;318(6041):75-8.
1985: Michael R Hayden; J A Soles; R H Ward
Age of onset in siblings of persons with juvenile Huntington disease.
Clinical genetics 1985;28(2):100-5.
1983: Michael R Hayden; J L Nichols
Molecular genetic approaches to the study of the nervous system.
Developmental neuroscience 1983;6(4-5):189-214.
1982: Michael R Hayden; J M MacGregor; D S Saffer; P H Beighton
The high frequency of juvenile Huntington's chorea in South Africa.
Journal of medical genetics 1982;19(2):94-7.
1982: Michael R Hayden; P Beighton
Genetic aspects of Huntington's chorea: results of a national survey.
American journal of medical genetics 1982;11(2):135-41.
1981: Michael R Hayden; A L Berkowicz; P H Beighton; C Yiptong
Huntington's chorea on the island of Mauritius.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1981;60(26):1001-2.
1981: P Beighton; Michael R Hayden
Huntington's chorea.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1981;59(8):250.
1980: Michael R Hayden; R Ehrlich; H Parker; S J Ferera
Social perspectives in Huntington's chorea.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1980;58(5):201-3.
1980: Michael R Hayden; H C Hopkins; M Macrea; P H Beighton
The origin of Huntington's chorea in the Afrikaner population of South Africa.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1980;58(5):197-200.
1980: Michael R Hayden; J M MacGregor; P H Beighton
The prevalence of Huntington's chorea in South Africa.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1980;58(5):193-6.
1977: Michael R Hayden; P Beighton
Huntington's chorea in the Cape coloured community of South Africa.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1977;52(22):886-8.
1977: Michael R Hayden; A I Vinik; M Paul; P Beighton
Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess.
Lancet 1977;2(8035):423-6.