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Michael Hayden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Macdonald Marcia L E; Bissada Nagat; Vallance Bruce A; Hayden Michael R
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis.
Fan Jing; Cowan Catherine M; Zhang Lily Y J; Hayden Michael R; Raymond Lynn A
Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.
Xian Xunde; Ding Yu; Zhang Ling; Wang Yanan; McNutt Michael A; Ross Colin; Hayden Michael R; Deng Xuming; Liu George
Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice.

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All Publications

2009: Macdonald Marcia L E; Bissada Nagat; Vallance Bruce A; Hayden Michael R
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis.
Biochimica et biophysica acta 2009;1791(12):1166-72.
2009: Fan Jing; Cowan Catherine M; Zhang Lily Y J; Hayden Michael R; Raymond Lynn A
Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(35):10928-38.
2009: Xian Xunde; Ding Yu; Zhang Ling; Wang Yanan; McNutt Michael A; Ross Colin; Hayden Michael R; Deng Xuming; Liu George
Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice.
Biochemical and biophysical research communications 2009;385(4):563-9.
2009: Huang Kun; Sanders Shaun; Singaraja Roshni; Orban Paul; Cijsouw Tony; Arstikaitis Pamela; Yanai Anat; Hayden Michael R; El-Husseini Alaa
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2605-15.
2009: Singaraja Roshni R; Kang Martin H; Vaid Kuljeet; Sanders Shaun S; Vilas Gonzalo L; Arstikaitis Pamela; Coutinho Jonathan; Drisdel Renaldo C; El-Husseini Alaa El Din; Green William N; Berthiaume Luc; Hayden Michael R
Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.
Circulation research 2009;105(2):138-47.
2009: Yeretssian Garabet; Doiron Karine; Shao Wei; Leavitt Blair R; Hayden Michael R; Nicholson Donald W; Saleh Maya
Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):9016-20.
2009: Vaessen S F C; Dallinga-Thie G M; Ross C J D; Splint L J; Castellani L W; Rensen P C N; Hayden M R; Schaap F G; Kuivenhoven J A
Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.
Journal of lipid research 2009;50(5):880-4.
2009: Xian Xunde; Liu Tingting; Yu Jia; Wang Yuhui; Miao Yifei; Zhang Jianjun; Yu Yan; Ross Colin; Karasinska Joanna M; Hayden Michael R; Liu George; Chui Dehua
Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(14):4681-5.
2009: Pouladi Mahmoud A; Graham Rona K; Karasinska Joanna M; Xie Yuanyun; Santos Rachelle Dar; Petersén Asa; Hayden Michael R
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.
Brain : a journal of neurology 2009;132(Pt 4):919-32.
2009: Ratovitski Tamara; Gucek Marjan; Jiang Haibing; Chighladze Ekaterine; Waldron Elaine; D'Ambola James; Hou Zhipeng; Liang Yideng; Poirier Michelle A; Hirschhorn Ricky R; Graham Rona; Hayden Michael R; Cole Robert N; Ross Christopher A
Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.
The Journal of biological chemistry 2009;284(16):10855-67.
2009: Brunham Liam R; Singaraja Roshni R; Duong MyNgan; Timmins Jenelle M; Fievet Catherine; Bissada Nagat; Kang Martin H; Samra Amrit; Fruchart Jean-Charles; McManus Bruce; Staels Bart; Parks John S; Hayden Michael R
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):548-54.
2009: Karasinska Joanna M; Rinninger Franz; Lütjohann Dieter; Ruddle Piers; Franciosi Sonia; Kruit Janine K; Singaraja Roshni R; Hirsch-Reinshagen Veronica; Fan Jianjia; Brunham Liam R; Bissada Nagat; Ramakrishnan Rajasekhar; Wellington Cheryl L; Parks John S; Hayden Michael R
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3579-89.
2009: Ehrnhoefer Dagmar E; Butland Stefanie L; Pouladi Mahmoud A; Hayden Michael R
Mouse models of Huntington disease: variations on a theme.
Disease models & mechanisms 2009;2(3-4):123-9.
2009: Warby Simon C; Montpetit Alexandre; Hayden Anna R; Carroll Jeffrey B; Butland Stefanie L; Visscher Henk; Collins Jennifer A; Semaka Alicia; Hudson Thomas J; Hayden Michael R
CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.
American journal of human genetics 2009;84(3):351-66.
2009: MacDonald Marcia L E; van Eck Miranda; Hildebrand Reeni B; Wong Brian W C; Bissada Nagat; Ruddle Piers; Kontush Anatol; Hussein Hala; Pouladi Mahmoud A; Chapman M John; Fievet Catherine; van Berkel Theo J C; Staels Bart; McManus Bruce M; Hayden Michael R
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(3):341-7.
2009: Wang Y; Sternfeld L; Yang F; Rodriguez J A; Ross C; Hayden M R; Carriere F; Liu G; Hofer W; Schulz I
Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells.
Gut 2009;58(3):422-30.
2009: Graham Rona K; Pouladi Mahmoud A; Joshi Prasad; Lu Ge; Deng Yu; Wu Nan-Ping; Figueroa Bryan E; Metzler Martina; André Véronique M; Slow Elizabeth J; Raymond Lynn; Friedlander Robert; Levine Michael S; Leavitt Blair R; Hayden Michael R
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2193-204.
2009: Warby Simon C; Doty Crystal N; Graham Rona K; Shively Jonathan; Singaraja Roshni R; Hayden Michael R
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
Molecular and cellular neurosciences 2009;40(2):121-7.
2009: Bombard Yvonne; Veenstra Gerry; Friedman Jan M; Creighton Susan; Currie Lauren; Paulsen Jane S; Bottorff Joan L; Hayden Michael R;
Perceptions of genetic discrimination among people at risk for Huntington's disease: a cross sectional survey.
BMJ (Clinical research ed.) 2009;338():b2175.
2008: Stroes Erik S; Nierman Melchior C; Meulenberg Janneke J; Franssen Remco; Twisk Jaap; Henny C Pieter; Maas Mario M; Zwinderman Aeilko H; Ross Colin; Aronica Eleonora; High Katherine A; Levi Marcel M; Hayden Michael R; Kastelein John J; Kuivenhoven Jan Albert
Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2303-4.
2008: Cowan Catherine M; Fan Mannie M Y; Fan Jing; Shehadeh Jacqueline; Zhang Lily Y J; Graham Rona K; Hayden Michael R; Raymond Lynn A
Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12725-35.
2008: Brunham Liam R; Kastelein John J P; Hayden Michael R
ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease.
JAMA : the journal of the American Medical Association 2008;300(17):1997-8; author reply 1998.
2008: Björkqvist Maria; Wild Edward J; Thiele Jenny; Silvestroni Aurelio; Andre Ralph; Lahiri Nayana; Raibon Elsa; Lee Richard V; Benn Caroline L; Soulet Denis; Magnusson Anna; Woodman Ben; Landles Christian; Pouladi Mahmoud A; Hayden Michael R; Khalili-Shirazi Azadeh; Lowdell Mark W; Brundin Patrik; Bates Gillian P; Leavitt Blair R; Möller Thomas; Tabrizi Sarah J
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
The Journal of experimental medicine 2008;205(8):1869-77.
2008: Warby Simon C; Doty Crystal N; Graham Rona K; Carroll Jeffrey B; Yang Yu-Zhou; Singaraja Roshni R; Overall Christopher M; Hayden Michael R
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Human molecular genetics 2008;17(15):2390-404.
2008: Zhang Hua; Li Qin; Graham Rona K; Slow Elizabeth; Hayden Michael R; Bezprozvanny Ilya
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
Neurobiology of disease 2008;31(1):80-8.
2008: Lerch Jason P; Carroll Jeffrey B; Dorr Adrienne; Spring Shoshana; Evans Alan C; Hayden Michael R; Sled John G; Henkelman R Mark
Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease.
NeuroImage 2008;41(2):243-51.
2008: Penziner Elizabeth; Williams Janet K; Erwin Cheryl; Bombard Yvonne; Wallis Anne; Beglinger Leigh J; Hayden Michael R; Paulsen Jane S
Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147(3):320-5.
2008: Bombard Yvonne; Penziner Elizabeth; Suchowersky Oksana; Guttman Mark; Paulsen Jane S; Bottorff Joan L; Hayden Michael R
Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease.
European journal of human genetics : EJHG 2008;16(3):279-89.
2008: Brunham Liam R; Kruit Janine K; Verchere C Bruce; Hayden Michael R
Cholesterol in islet dysfunction and type 2 diabetes.
The Journal of clinical investigation 2008;118(2):403-8.
2008: Zhang Xiaohong; Qi Rong; Xian Xunde; Yang Fei; Blackstein Michael; Deng Xuming; Fan Jianglin; Ross Colin; Karasinska Joanna; Hayden Michael R; Liu George
Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.
Circulation research 2008;102(2):250-6.
2008: Fan Mannie M Y; Zhang Hong; Hayden Michael R; Pelech Steven L; Raymond Lynn A
Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.
Journal of neurochemistry 2008;104(3):790-805.
2008: MacDonald Marcia L E; Singaraja Roshni R; Bissada Nagat; Ruddle Piers; Watts Russell; Karasinska Joanna M; Gibson William T; Fievet Catherine; Vance Jean E; Staels Bart; Hayden Michael R
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.
Journal of lipid research 2008;49(1):217-29.
2008: Lerch Jason P; Carroll Jeffrey B; Spring Shoshana; Bertram Lisa N; Schwab Claudia; Hayden Michael R; Henkelman R Mark
Automated deformation analysis in the YAC128 Huntington disease mouse model.
NeuroImage 2008;39(1):32-9.
2007: Ratovitski Tamara; Nakamura Masayuki; D'Ambola James; Chighladze Ekaterine; Liang Yideng; Wang Wenfei; Graham Rona; Hayden Michael R; Borchelt David R; Hirschhorn Ricky R; Ross Christopher A
N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.
Cell cycle (Georgetown, Tex.) 2007;6(23):2970-81.
2007: Fernandes Herman B; Baimbridge Kenneth G; Church John; Hayden Michael R; Raymond Lynn A
Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13614-23.
2007: Parker J Alex; Metzler Martina; Georgiou John; Mage Marilyne; Roder John C; Rose Ann M; Hayden Michael R; Néri Christian
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):11056-64.
2007: Ross Colin J D; Carleton Bruce; Warn Dana G; Stenton Sunita B; Rassekh Shahrad Rod; Hayden Michael R
Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children.
Annals of the New York Academy of Sciences 2007;1110():177-92.
2007: Valenza Marta; Carroll Jeffrey B; Leoni Valerio; Bertram Lisa N; Björkhem Ingeman; Singaraja Roshni R; Di Donato Stefano; Lutjohann Dieter; Hayden Michael R; Cattaneo Elena
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.
Human molecular genetics 2007;16(18):2187-98.
2007: Kuhn Alexandre; Goldstein Darlene R; Hodges Angela; Strand Andrew D; Sengstag Thierry; Kooperberg Charles; Becanovic Kristina; Pouladi Mahmoud A; Sathasivam Kirupa; Cha Jang-Ho J; Hannan Anthony J; Hayden Michael R; Leavitt Blair R; Dunnett Stephen B; Ferrante Robert J; Albin Roger; Shelbourne Peggy; Delorenzi Mauro; Augood Sarah J; Faull Richard L M; Olson James M; Bates Gillian P; Jones Lesley; Luthi-Carter Ruth
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Human molecular genetics 2007;16(15):1845-61.
2007: Johnson Shannon A; Stout Julie C; Solomon Andrea C; Langbehn Douglas R; Aylward Elizabeth H; Cruce Christina B; Ross Christopher A; Nance Martha; Kayson Elise; Julian-Baros Elaine; Hayden Michael R; Kieburtz Karl; Guttman Mark; Oakes David; Shoulson Ira; Beglinger Leigh; Duff Kevin; Penziner Elizabeth; Paulsen Jane S;
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease.
Brain : a journal of neurology 2007;130(Pt 7):1732-44.
2007: Benn C L; Slow E J; Farrell L A; Graham R; Deng Y; Hayden M R; Cha J-H J
Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.
Neuroscience 2007;147(2):354-72.
2007: Van Raamsdonk Jeremy M; Murphy Zoe; Selva David M; Hamidizadeh Reza; Pearson Jacqueline; Petersén Asa; Björkqvist Maria; Muir Cameron; Mackenzie Ian R; Hammond Geoffrey L; Vogl A Wayne; Hayden Michael R; Leavitt Blair R
Testicular degeneration in Huntington disease.
Neurobiology of disease 2007;26(3):512-20.
2007: Goldberg Y P; MacFarlane J; MacDonald M L; Thompson J; Dube M-P; Mattice M; Fraser R; Young C; Hossain S; Pape T; Payne B; Radomski C; Donaldson G; Ives E; Cox J; Younghusband H B; Green R; Duff A; Boltshauser E; Grinspan G A; Dimon J H; Sibley B G; Andria G; Toscano E; Kerdraon J; Bowsher D; Pimstone S N; Samuels M E; Sherrington R; Hayden M R
Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations.
Clinical genetics 2007;71(4):311-9.
2007: Fan Mannie M Y; Fernandes Herman B; Zhang Lily Y J; Hayden Michael R; Raymond Lynn A
Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3768-79.
2007: Van Raamsdonk Jeremy M; Warby Simon C; Hayden Michael R
Selective degeneration in YAC mouse models of Huntington disease.
Brain research bulletin 2007;72(2-3):124-31.
2007: Solomon Andrea C; Stout Julie C; Johnson Shannon A; Langbehn Douglas R; Aylward Elizabeth H; Brandt Jason; Ross Christopher A; Beglinger Leigh; Hayden Michael R; Kieburtz Karl; Kayson Elise; Julian-Baros Elaine; Duff Kevin; Guttman Mark; Nance Martha; Oakes David; Shoulson Ira; Penziner Elizabeth; Paulsen Jane S;
Verbal episodic memory declines prior to diagnosis in Huntington's disease.
Neuropsychologia 2007;45(8):1767-76.
2007: Van Raamsdonk Jeremy M; Metzler Martina; Slow Elizabeth; Pearson Jacqueline; Schwab Claudia; Carroll Jeffrey; Graham Rona K; Leavitt Blair R; Hayden Michael R
Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.
Neurobiology of disease 2007;26(1):189-200.
2007: Hirsch-Reinshagen Veronica; Chan Jennifer Y; Wilkinson Anna; Tanaka Tracie; Fan Jianjia; Ou George; Maia Luis F; Singaraja Roshni R; Hayden Michael R; Wellington Cheryl L
Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.
Journal of lipid research 2007;48(4):914-23.
2007: Ross Colin J D; Katzov Hagit; Carleton Bruce; Hayden Michael R
Pharmacogenomics and its implications for autoimmune disease.
Journal of autoimmunity 2007;28(2-3):122-8.
2007: Brunham Liam R; Kruit Janine K; Pape Terry D; Timmins Jenelle M; Reuwer Anne Q; Vasanji Zainisha; Marsh Brad J; Rodrigues Brian; Johnson James D; Parks John S; Verchere C Bruce; Hayden Michael R
Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Nature medicine 2007;13(3):340-7.
2007: Bombard Y; Penziner E; Decolongon J; Klimek M L N; Creighton S; Suchowersky O; Guttman M; Paulsen J S; Bottorff J L; Hayden M R
Managing genetic discrimination: strategies used by individuals found to have the Huntington disease mutation.
Clinical genetics 2007;71(3):220-31.
2007: Khatchadourian Karine; Smith Charles E; Metzler Martina; Gregory Mary; Hayden Michael R; Cyr Daniel G; Hermo Louis
Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice.
Molecular reproduction and development 2007;74(3):341-59.
2007: Metzler Martina; Gan Lu; Wong Tak Pan; Liu Lidong; Helm Jeffrey; Liu Lili; Georgiou John; Wang Yushan; Bissada Nagat; Cheng Kevin; Roder John C; Wang Yu Tian; Hayden Michael R
NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(9):2298-308.
2007: Wang Jinyu; Xian Xunde; Huang Wei; Chen Li; Wu Liling; Zhu Yi; Fan Jianglin; Ross Colin; Hayden Michael R; Liu George
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):197-203.
2007: Orban Paul; Devon Rebecca S; Hayden Michael R; Leavitt Blair R
Chapter 15 Juvenile amyotrophic lateral sclerosis.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2007;82():301-12.
2007: Butland Stefanie L; Devon Rebecca S; Huang Yong; Mead Carri-Lyn; Meynert Alison M; Neal Scott J; Lee Soo Sen; Wilkinson Anna; Yang George S; Yuen Macaire M S; Hayden Michael R; Holt Robert A; Leavitt Blair R; Ouellette B F Francis
CAG-encoded polyglutamine length polymorphism in the human genome.
BMC genomics 2007;8():126.
2006: Zhang Yu; Leavitt Blair R; van Raamsdonk Jeremy M; Dragatsis Ioannis; Goldowitz Dan; MacDonald Marcy E; Hayden Michael R; Friedlander Robert M
Huntingtin inhibits caspase-3 activation.
The EMBO journal 2006;25(24):5896-906.
2006: Houde Caroline; Dickinson Robin J; Houtzager Vicky M; Cullum Rebecca; Montpetit Rachel; Metzler Martina; Simpson Elizabeth M; Roy Sophie; Hayden Michael R; Hoodless Pamela A; Nicholson Donald W
Hippi is essential for node cilia assembly and Sonic hedgehog signaling.
Developmental biology 2006;300(2):523-33.
2006: Leavitt Blair R; Hayden Michael R
Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?
Nature clinical practice. Neurology 2006;2(10):536-7.
2006: Semaka A; Creighton S; Warby S; Hayden M R
Predictive testing for Huntington disease: interpretation and significance of intermediate alleles.
Clinical genetics 2006;70(4):283-94.
2006: Burgess Braydon L; McIsaac Sean A; Naus Kathryn E; Chan Jeniffer Y; Tansley Gavin H K; Yang Jing; Miao Fudan; Ross Colin J D; van Eck Miranda; Hayden Michael R; van Nostrand William; St George-Hyslop Peter; Westaway David; Wellington Cheryl L
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Neurobiology of disease 2006;24(1):114-27.
2006: Brunham Liam R; Kruit Janine K; Pape Terry D; Parks John S; Kuipers Folkert; Hayden Michael R
Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Circulation research 2006;99(7):672-4.
2006: Singaraja Roshni R; Van Eck Miranda; Bissada Nagat; Zimetti Francesca; Collins Heidi L; Hildebrand Reeni B; Hayden Anna; Brunham Liam R; Kang Martin H; Fruchart Jean-Charles; Van Berkel Theo J C; Parks John S; Staels Bart; Rothblat George H; Fiévet Catherine; Hayden Michael R
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Circulation 2006;114(12):1301-9.
2006: Singaraja Roshni R; Visscher Henk; James Erick R; Chroni Angeliki; Coutinho Jonathan M; Brunham Liam R; Kang Martin H; Zannis Vassilis I; Chimini Giovanna; Hayden Michael R
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
Circulation research 2006;99(4):389-97.
2006: Slow Elizabeth J; Graham Rona K; Hayden Michael R
To be or not to be toxic: aggregations in Huntington and Alzheimer disease.
Trends in genetics : TIG 2006;22(8):408-11.
2006: Singaraja Roshni R; Stahmer Bjorn; Brundert May; Merkel Martin; Heeren Joerg; Bissada Nagat; Kang Martin; Timmins Jenelle M; Ramakrishnan Rajasekhar; Parks John S; Hayden Michael R; Rinninger Franz
Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1821-7.
2006: Guidetti Paolo; Bates Gillian P; Graham Rona K; Hayden Michael R; Leavitt Blair R; MacDonald Marcy E; Slow Elizabeth J; Wheeler Vanessa C; Woodman Ben; Schwarcz Robert
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Neurobiology of disease 2006;23(1):190-7.
2006: Graham Rona K; Deng Yu; Slow Elizabeth J; Haigh Brendan; Bissada Nagat; Lu Ge; Pearson Jacqueline; Shehadeh Jacqueline; Bertram Lisa; Murphy Zoe; Warby Simon C; Doty Crystal N; Roy Sophie; Wellington Cheryl L; Leavitt Blair R; Raymond Lynn A; Nicholson Donald W; Hayden Michael R
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Cell 2006;125(6):1179-91.
2006: Devon R S; Orban P C; Gerrow K; Barbieri M A; Schwab C; Cao L P; Helm J R; Bissada N; Cruz-Aguado R; Davidson T-L; Witmer J; Metzler M; Lam C K; Tetzlaff W; Simpson E M; McCaffery J M; El-Husseini A E; Leavitt B R; Hayden M R
Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9595-600.
2006: Yanai Anat; Huang Kun; Kang Rujun; Singaraja Roshni R; Arstikaitis Pamela; Gan Lu; Orban Paul C; Mullard Asher; Cowan Catherine M; Raymond Lynn A; Drisdel Renaldo C; Green William N; Ravikumar Brinda; Rubinsztein David C; El-Husseini Alaa; Hayden Michael R
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nature neuroscience 2006;9(6):824-31.
2006: Rip Jaap; Nierman Melchior C; Ross Colin J; Jukema Jan Wouter; Hayden Michael R; Kastelein John J P; Stroes Erik S G; Kuivenhoven Jan Albert
Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):1236-45.
2006: Ross Colin J D; Twisk Jaap; Bakker Andrew C; Miao Fudan; Verbart Dennis; Rip Jaap; Godbey Tamara; Dijkhuizen Paul; Hermens Wim T J M C; Kastelein John J P; Kuivenhoven Jan Albert; Meulenberg Janneke M; Hayden Michael R
Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation.
Human gene therapy 2006;17(5):487-99.
2006: Van Raamsdonk Jeremy M; Gibson William T; Pearson Jacqueline; Murphy Zoe; Lu Ge; Leavitt Blair R; Hayden Michael R
Body weight is modulated by levels of full-length huntingtin.
Human molecular genetics 2006;15(9):1513-23.
2006: Brunham Liam R; Kruit Janine K; Iqbal Jahangir; Fievet Catherine; Timmins Jenelle M; Pape Terry D; Coburn Bryan A; Bissada Nagat; Staels Bart; Groen Albert K; Hussain M Mahmood; Parks John S; Kuipers Folkert; Hayden Michael R
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
The Journal of clinical investigation 2006;116(4):1052-62.
2006: Van Eck Miranda; Singaraja Roshni R; Ye Dan; Hildebrand Reeni B; James Erick R; Hayden Michael R; Van Berkel Theo J C
Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):929-34.
2006: Zhao Tieqiang; Guo Jun; Li Hui; Huang Wei; Xian Xunde; Ross Colin J D; Hayden Michael R; Wen Zongyao; Liu George
Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia.
Biochemical and biophysical research communications 2006;341(4):1066-71.
2006: Bae Byoung-Il; Hara Makoto R; Cascio Matthew B; Wellington Cheryl L; Hayden Michael R; Ross Christopher A; Ha Hyo Chol; Li Xiao-Jiang; Snyder Solomon H; Sawa Akira
Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3405-9.
2006: Leavitt Blair R; van Raamsdonk Jeremy M; Shehadeh Jacqueline; Fernandes Herman; Murphy Zoe; Graham Rona K; Wellington Cheryl L; Raymond Lynn A; Hayden Michael R
Wild-type huntingtin protects neurons from excitotoxicity.
Journal of neurochemistry 2006;96(4):1121-9.
2006: van Leuven Sander I; Kastelein John J P; Allison Anthony C; Hayden Michael R; Stroes Erik S G
Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles?
Cardiovascular research 2006;69(2):341-7.
2006: Graham Rona K; Slow Elizabeth J; Deng Yu; Bissada Nagat; Lu Ge; Pearson Jacqueline; Shehadeh Jacqueline; Leavitt Blair R; Raymond Lynn A; Hayden Michael R
Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.
Neurobiology of disease 2006;21(2):444-55.
2006: Shehadeh Jacqueline; Fernandes Herman B; Zeron Mullins Melinda M; Graham Rona K; Leavitt Blair R; Hayden Michael R; Raymond Lynn A
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease.
Neurobiology of disease 2006;21(2):392-403.
2006: Van Raamsdonk Jeremy M; Pearson Jacqueline; Murphy Zoe; Hayden Michael R; Leavitt Blair R
Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.
BMC neuroscience 2006;7():80.
2006: Brunham Liam R; Singaraja Roshni R; Hayden Michael R
Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis.
Annual review of nutrition 2006;26():105-29.
2005: Brunham Liam R; Singaraja Roshni R; Pape Terry D; Kejariwal Anish; Thomas Paul D; Hayden Michael R
Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene.
PLoS genetics 2005;1(6):e83.
2005: Van Raamsdonk Jeremy M; Murphy Zoe; Slow Elizabeth J; Leavitt Blair R; Hayden Michael R
Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.
Human molecular genetics 2005;14(24):3823-35.
2005: Hirsch-Reinshagen Veronica; Maia Luis F; Burgess Braydon L; Blain Jean-Francois; Naus Kathryn E; McIsaac Sean A; Parkinson Pamela F; Chan Jennifer Y; Tansley Gavin H; Hayden Michael R; Poirier Judes; Van Nostrand William; Wellington Cheryl L
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
The Journal of biological chemistry 2005;280(52):43243-56.
2005: Van Raamsdonk Jeremy M; Pearson Jacqueline; Rogers Daniel A; Lu Ge; Barakauskas Vilte E; Barr Alasdair M; Honer William G; Hayden Michael R; Leavitt Blair R
Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.
Experimental neurology 2005;196(2):266-72.
2005: Rip Jaap; Nierman Melchior C; Sierts Jeroen A; Petersen Wilma; Van den Oever Karin; Van Raalte Daniel; Ross Colin J D; Hayden Michael R; Bakker Andrew C; Dijkhuizen Paul; Hermens Wim T; Twisk Jaap; Stroes Erik; Kastelein John J P; Kuivenhoven Jan Albert; Meulenberg Janneke M
Gene therapy for lipoprotein lipase deficiency: working toward clinical application.
Human gene therapy 2005;16(11):1276-86.
2005: Van Raamsdonk Jeremy M; Pearson Jacqueline; Bailey Craig D C; Rogers Daniel A; Johnson Gail V W; Hayden Michael R; Leavitt Blair R
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.
Journal of neurochemistry 2005;95(1):210-20.
2005: van Leuven Sander I; Kastelein John J P; Hayden Michael R; d'Cruz David; Hughes Graham R; Stroes Erik S
Cardiovascular disease in systemic lupus erythematosus: has the time for action come?
Current opinion in lipidology 2005;16(5):501-6.
2005: Kegel Kimberly B; Sapp Ellen; Yoder Jennifer; Cuiffo Benjamin; Sobin Lindsay; Kim Yun J; Qin Zheng-Hong; Hayden Michael R; Aronin Neil; Scott David L; Isenberg Gerhard; Goldmann Wolfgang H; DiFiglia Marian
Huntingtin associates with acidic phospholipids at the plasma membrane.
The Journal of biological chemistry 2005;280(43):36464-73.
2005: Singaraja Roshni R; James Erick R; Crim Jennifer; Visscher Henk; Chatterjee Alu; Hayden Michael R
Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1.
Journal of lipid research 2005;46(10):2061-71.
2005: Ross Colin J D; Liu Guoqing; Kuivenhoven Jan Albert; Twisk Jaap; Rip Jaap; van Dop Willemijn; Excoffon Katherine J D Ashbourne; Lewis Suzanne M E; Kastelein John J; Hayden Michael R
Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2143-50.
2005: Slow Elizabeth J; Graham Rona K; Osmand Alexander P; Devon Rebecca S; Lu Ge; Deng Yu; Pearson Jacqui; Vaid Kuljeet; Bissada Nagat; Wetzel Ronald; Leavitt Blair R; Hayden Michael R
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11402-7.
2005: Pinto John T; Van Raamsdonk Jeremy M; Leavitt Blair R; Hayden Michael R; Jeitner Thomas M; Thaler Howard T; Krasnikov Boris F; Cooper Arthur J L
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
Journal of neurochemistry 2005;94(4):1087-101.
2005: Warby Simon C; Chan Edmond Y; Metzler Martina; Gan Lu; Singaraja Roshni R; Crocker Susan F; Robertson Harold A; Hayden Michael R
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.
Human molecular genetics 2005;14(11):1569-77.
2005: Coutinho Jonathan M; Singaraja Roshni R; Kang Martin; Arenillas David J; Bertram Lisa N; Bissada Nagat; Staels Bart; Fruchart Jean-Charles; Fievet Catherine; Joseph-George Ann M; Wasserman Wyeth W; Hayden Michael R
Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis.
Journal of lipid research 2005;46(6):1113-23.
2005: Timmins Jenelle M; Lee Ji-Young; Boudyguina Elena; Kluckman Kimberly D; Brunham Liam R; Mulya Anny; Gebre Abraham K; Coutinho Jonathan M; Colvin Perry L; Smith Thomas L; Hayden Michael R; Maeda Nobuyo; Parks John S
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.
The Journal of clinical investigation 2005;115(5):1333-42.
2005: Van Raamsdonk Jeremy M; Pearson Jacqueline; Rogers Daniel A; Bissada Nagat; Vogl A Wayne; Hayden Michael R; Leavitt Blair R
Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.
Human molecular genetics 2005;14(10):1379-92.
2005: Van Raamsdonk Jeremy M; Pearson Jacqueline; Slow Elizabeth J; Hossain Sazzad M; Leavitt Blair R; Hayden Michael R
Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(16):4169-80.
2005: Devon Rebecca S; Schwab Claudia; Topp Justin D; Orban Paul C; Yang Yu-Zhou; Pape Terry D; Helm Jeffrey R; Davidson Tara-Lynne; Rogers Daniel A; Gros-Louis Francois; Rouleau Guy; Horazdovsky Bruce F; Leavitt Blair R; Hayden Michael R
Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood.
Neurobiology of disease 2005;18(2):243-57.
2005: Tang Tie-Shan; Slow Elizabeth; Lupu Vitalie; Stavrovskaya Irina G; Sugimori Mutsuyuki; Llinás Rodolfo; Kristal Bruce S; Hayden Michael R; Bezprozvanny Ilya
Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2602-7.
2005: Legendre-Guillemin Valerie; Metzler Martina; Lemaire Jean-Francois; Philie Jacynthe; Gan Lu; Hayden Michael R; McPherson Peter S
Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.
The Journal of biological chemistry 2005;280(7):6101-8.
2005: Hayden Michael R; Bombard Yvonne
Psychosocial effects of predictive testing for Huntington's disease.
Advances in neurology 2005;96():226-39.
2004: Huang Kun; Yanai Anat; Kang Rujun; Arstikaitis Pamela; Singaraja Roshni R; Metzler Martina; Mullard Asher; Haigh Brendan; Gauthier-Campbell Catherine; Gutekunst Claire-Anne; Hayden Michael R; El-Husseini Alaa
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Neuron 2004;44(6):977-86.
2004: Guan Jing-Zhi; Tamasawa Naoki; Brunham Liam R; Matsui Jun; Murakami Hiroshi; Suda Toshihiro; Ochiai Shigeru; Tsutsui Masahiro; Kudou Kenji; Satoh Kei; Hayden Michael R
A case of Tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1.
American journal of medical genetics. Part A 2004;130A(4):398-401.
2004: Li Lijun; Murphy Timothy H; Hayden Michael R; Raymond Lynn A
Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease.
Journal of neurophysiology 2004;92(5):2738-46.
2004: Hovingh G Kees; Brownlie Alison; Bisoendial Radjesh J; Dube Marie Pierre; Levels Johannes H M; Petersen Wilma; Dullaart Robin P F; Stroes Erik S G; Zwinderman Aeilko H; de Groot Eric; Hayden Michael R; Kuivenhoven Jan Albert; Kastelein John J P
A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease.
Journal of the American College of Cardiology 2004;44(7):1429-35.
2004: Tang Tie-Shan; Tu Huiping; Orban Paul C; Chan Edmond Y W; Hayden Michael R; Bezprozvanny Ilya
HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons.
The European journal of neuroscience 2004;20(7):1779-87.
2004: Bezprozvanny Ilya; Hayden Michael R
Deranged neuronal calcium signaling and Huntington disease.
Biochemical and biophysical research communications 2004;322(4):1310-7.
2004: Ross Colin J D; Twisk Jaap; Meulenberg Janneke M; Liu Guoqing; van den Oever Karin; Moraal Ewoud; Hermens Wim T; Rip Jaap; Kastelein John J P; Kuivenhoven Jan Albert; Hayden Michael R
Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL(S447X) beneficial mutation.
Human gene therapy 2004;15(9):906-19.
2004: Hirsch-Reinshagen Veronica; Zhou Steven; Burgess Braydon L; Bernier Lise; McIsaac Sean A; Chan Jeniffer Y; Tansley Gavin H; Cohn Jeffrey S; Hayden Michael R; Wellington Cheryl L
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.
The Journal of biological chemistry 2004;279(39):41197-207.
2004: Djoussé Luc; Knowlton Beth; Hayden Michael R; Almqvist Elisabeth W; Brinkman Ryan R; Ross Christopher A; Margolis Russel L; Rosenblatt Adam; Durr Alexandra; Dode Catherine; Morrison Patrick J; Novelletto Andrea; Frontali Marina; Trent Ronald J A; McCusker Elizabeth; Gómez-Tortosa Estrella; Mayo Cabrero David; Jones Randi; Zanko Andrea; Nance Martha; Abramson Ruth K; Suchowersky Oksana; Paulsen Jane S; Harrison Madaline B; Yang Qiong; Cupples L Adrienne; Mysore Jayalakshmi; Gusella James F; MacDonald Marcy E; Myers Richard H
Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.
Neurogenetics 2004;5(2):109-14.
2004: Selva David M; Hirsch-Reinshagen Veronica; Burgess Braydon; Zhou Steven; Chan Jeniffer; McIsaac Sean; Hayden Michael R; Hammond Geoffrey L; Vogl A Wayne; Wellington Cheryl L
The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.
Journal of lipid research 2004;45(6):1040-50.
2004: Saleh Maya; Vaillancourt John P; Graham Rona K; Huyck Matthew; Srinivasula Srinivasa M; Alnemri Emad S; Steinberg Martin H; Nolan Vikki; Baldwin Clinton T; Hotchkiss Richard S; Buchman Timothy G; Zehnbauer Barbara A; Hayden Michael R; Farrer Lindsay A; Roy Sophie; Nicholson Donald W
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2004: Delatycki M B; Allen K J; Gow P; MacFarlane J; Radomski C; Thompson J; Hayden M R; Goldberg Y P; Samuels M E
A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis.
Clinical genetics 2004;65(5):378-83.
2004: Lafreniere Ronald G; MacDonald Marcia L E; Dube Marie-Pierre; MacFarlane Julie; O'Driscoll Mary; Brais Bernard; Meilleur Sebastien; Brinkman Ryan R; Dadivas Owen; Pape Terry; Platon Christele; Radomski Chris; Risler Jenni; Thompson Jay; Guerra-Escobio Ana-Maria; Davar Gudarz; Breakefield Xandra O; Pimstone Simon N; Green Roger; Pryse-Phillips William; Goldberg Y Paul; Younghusband H Banfield; Hayden Michael R; Sherrington Robin; Rouleau Guy A; Samuels Mark E;
Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates.
American journal of human genetics 2004;74(5):1064-73.
2004: Gafni Juliette; Hermel Evan; Young Jessica E; Wellington Cheryl L; Hayden Michael R; Ellerby Lisa M
Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
The Journal of biological chemistry 2004;279(19):20211-20.
2004: Harper Peter S; Gevers Sjef; de Wert Guido; Creighton Susan; Bombard Yvonne; Hayden Michael R
Genetic testing and Huntington's disease: issues of employment.
Lancet neurology 2004;3(4):249-52.
2004: Langbehn D R; Brinkman R R; Falush D; Paulsen J S; Hayden M R;
A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.
Clinical genetics 2004;65(4):267-77.
2004: Hermel E; Gafni J; Propp S S; Leavitt B R; Wellington C L; Young J E; Hackam A S; Logvinova A V; Peel A L; Chen S F; Hook V; Singaraja R; Krajewski S; Goldsmith P C; Ellerby H M; Hayden M R; Bredesen D E; Ellerby L M
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Cell death and differentiation 2004;11(4):424-38.
2004: Zeron Melinda M; Fernandes Herman B; Krebs Claudia; Shehadeh Jacqueline; Wellington Cheryl L; Leavitt Blair R; Baimbridge Kenneth G; Hayden Michael R; Raymond Lynn A
Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease.
Molecular and cellular neurosciences 2004;25(3):469-79.
2004: Hovingh G K; Kuivenhoven J A; Bisoendial R J; Groen A K; van Dam M; van Tol A; Wellington C; Hayden M R; Smelt A H M; Kastelein J J P
HDL deficiency and atherosclerosis: lessons from Tangier disease.
Journal of internal medicine 2004;255(2):299-301.
2004: Qin Zheng-Hong; Wang Yumei; Sapp Ellen; Cuiffo Benjamin; Wanker Erich; Hayden Michael R; Kegel Kimberly B; Aronin Neil; DiFiglia Marian
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(1):269-81.
2004: Papanikolaou George; Samuels Mark E; Ludwig Erwin H; MacDonald Marcia L E; Franchini Patrick L; Dubé Marie-Pierre; Andres Lisa; MacFarlane Julie; Sakellaropoulos Nikos; Politou Marianna; Nemeth Elizabeta; Thompson Jay; Risler Jenni K; Zaborowska Catherine; Babakaiff Ryan; Radomski Christopher C; Pape Terry D; Davidas Owen; Christakis John; Brissot Pierre; Lockitch Gillian; Ganz Tomas; Hayden Michael R; Goldberg Y Paul
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.
Nature genetics 2004;36(1):77-82.
2003: Hand Collette K; Devon Rebecca S; Gros-Louis Francois; Rochefort Daniel; Khoris Jawad; Meininger Vincent; Bouchard Jean-Pierre; Camu William; Hayden Michael R; Rouleau Guy A
Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis.
Archives of neurology 2003;60(12):1768-71.
2003: Kuivenhoven J A; Hovingh G K; van Tol A; Jauhiainen M; Ehnholm C; Fruchart J C; Brinton E A; Otvos J D; Smelt A H M; Brownlee A; Zwinderman A H; Hayden M R; Kastelein J J P
Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size.
Atherosclerosis 2003;171(2):311-9.
2003: Li Lijun; Fan Mannie; Icton Carolyn D; Chen Nansheng; Leavitt Blair R; Hayden Michael R; Murphy Tim H; Raymond Lynn A
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.
Neurobiology of aging 2003;24(8):1113-21.
2003: Brunham Liam R; Hayden Michael R
Clarity is essential when using nucleotide number systems.
Atherosclerosis 2003;170(2):349.
2003: Almqvist E W; Brinkman R R; Wiggins S; Hayden M R;
Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease.
Clinical genetics 2003;64(4):300-9.
2003: Zhang Yu; Li Mingwei; Drozda Martin; Chen Minghua; Ren Shengjun; Mejia Sanchez Rene O; Leavitt Blair R; Cattaneo Elena; Ferrante Robert J; Hayden Michael R; Friedlander Robert M
Depletion of wild-type huntingtin in mouse models of neurologic diseases.
Journal of neurochemistry 2003;87(1):101-6.
2003: Devon R S; Helm J R; Rouleau G A; Leitner Y; Lerman-Sagie T; Lev D; Hayden M R
The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings.
Clinical genetics 2003;64(3):210-5.
2003: Zuccato Chiara; Tartari Marzia; Crotti Andrea; Goffredo Donato; Valenza Marta; Conti Luciano; Cataudella Tiziana; Leavitt Blair R; Hayden Michael R; Timmusk Tõnis; Rigamonti Dorotea; Cattaneo Elena
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Nature genetics 2003;35(1):76-83.
2003: Hoogendijk C F; Scholtz C L; Pimstone S M; Ehrenborg E; Kastelein J J P; Defesche J C; Thiart R; du Plessis L; de Villiers J N P; Zaahl M G; Delport R; Rubinsztein D C; Raffel L J; Grim C E; Mediene-Benchekor S; Amouyel P; Brousseau T; Steyn K; Lombard C J; Hayden M R; Kotze M J
Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element.
Molecular and cellular probes 2003;17(4):175-81.
2003: Singaraja Roshni R; Brunham Liam R; Visscher Henk; Kastelein John J P; Hayden Michael R
Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1322-32.
2003: Hussain Natasha K; Yamabhai Montarop; Bhakar Asha L; Metzler Martina; Ferguson Stephen S G; Hayden Michael R; McPherson Peter S; Kay Brian K
A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding.
The Journal of biological chemistry 2003;278(31):28823-30.
2003: Wellington Cheryl L; Brunham Liam R; Zhou Steven; Singaraja Roshni R; Visscher Henk; Gelfer Allison; Ross Colin; James Erick; Liu Guoqing; Huber Mary T; Yang Yu-Zhou; Parks Robin J; Groen Albert; Fruchart-Najib Jamila; Hayden Michael R
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.
Journal of lipid research 2003;44(8):1470-80.
2003: Tang Tie-Shan; Tu Huiping; Chan Edmond Y W; Maximov Anton; Wang Zhengnan; Wellington Cheryl L; Hayden Michael R; Bezprozvanny Ilya
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.
Neuron 2003;39(2):227-39.
2003: Metzler Martina; Li Bo; Gan Lu; Georgiou John; Gutekunst Claire-Anne; Wang Yushan; Torre Enrique; Devon Rebecca S; Oh Rosemary; Legendre-Guillemin Valerie; Rich Mark; Alvarez Christine; Gertsenstein Marina; McPherson Peter S; Nagy Andras; Wang Yu Tian; Roder John C; Raymond Lynn A; Hayden Michael R
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
The EMBO journal 2003;22(13):3254-66.
2003: Slow Elizabeth J; van Raamsdonk Jeremy; Rogers Daniel; Coleman Sarah H; Graham Rona K; Deng Yu; Oh Rosemary; Bissada Nagat; Hossain Sazzad M; Yang Yu-Zhou; Li Xiao-Jiang; Simpson Elizabeth M; Gutekunst Claire-Anne; Leavitt Blair R; Hayden Michael R
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Human molecular genetics 2003;12(13):1555-67.
2003: Creighton S; Almqvist E W; MacGregor D; Fernandez B; Hogg H; Beis J; Welch J P; Riddell C; Lokkesmoe R; Khalifa M; MacKenzie J; Sajoo A; Farrell S; Robert F; Shugar A; Summers A; Meschino W; Allingham-Hawkins D; Chiu T; Hunter A; Allanson J; Hare H; Schween J; Collins L; Sanders S; Greenberg C; Cardwell S; Lemire E; MacLeod P; Hayden M R
Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000.
Clinical genetics 2003;63(6):462-75.
2003: Bisoendial Radjesh J; Hovingh G Kees; Levels Johannes H M; Lerch Peter G; Andresen Irmgard; Hayden Michael R; Kastelein John J P; Stroes Erik S G
Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein.
Circulation 2003;107(23):2944-8.
2003: Hovingh G Kees; Van Wijland Michel J A; Brownlie Alison; Bisoendial Radjesh J; Hayden Michael R; Kastelein John J P; Groen Albert K
The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia.
Journal of lipid research 2003;44(6):1251-5.
2003: Mulligan Jacob D; Flowers Matthew T; Tebon Angie; Bitgood J James; Wellington Cheryl; Hayden Michael R; Attie Alan D
ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens.
The Journal of biological chemistry 2003;278(15):13356-66.
2003: Nucifora Frederick C; Ellerby Lisa M; Wellington Cheryl L; Wood Jon D; Herring William J; Sawa Akira; Hayden Michael R; Dawson Valina L; Dawson Ted M; Ross Christopher A
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.
The Journal of biological chemistry 2003;278(15):13047-55.
2003: Hayden Michael R
Predictive testing for Huntington's disease: a universal model?
Lancet neurology 2003;2(3):141-2.
2003: Gros-Louis François; Meijer Inge A; Hand Collette K; Dubé Marie-Pierre; MacGregor Daune L; Seni Marie-Hélène; Devon Rebecca S; Hayden Michael R; Andermann Frederick; Andermann Eva; Rouleau Guy A
An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred.
Annals of neurology 2003;53(1):144-5.
2002: Wellington Cheryl L; Yang Yu-Zhou; Zhou Stephen; Clee Susanne M; Tan Bing; Hirano Kenichi; Zwarts Karin; Kwok Anita; Gelfer Allison; Marcil Michel; Newman Scott; Roomp Kirsten; Singaraja Roshni; Collins Jennifer; Zhang Lin-Hua; Groen Albert K; Hovingh Kees; Brownlie Alison; Tafuri Sherrie; Genest Jacques; Kastelein John J P; Hayden Michael R
Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.
Journal of lipid research 2002;43(11):1939-49.
2002: Attie Alan D; Krauss Ronald M; Gray-Keller Mark P; Brownlie Alison; Miyazaki Makoto; Kastelein John J; Lusis Aldons J; Stalenhoef Anton F H; Stoehr Jonathan P; Hayden Michael R; Ntambi James M
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia.
Journal of lipid research 2002;43(11):1899-907.
2002: Singaraja Roshni R; Hadano Shinji; Metzler Martina; Givan Scott; Wellington Cheryl L; Warby Simon; Yanai Anat; Gutekunst Claire-Anne; Leavitt Blair R; Yi Hong; Fichter Keith; Gan Lu; McCutcheon Krista; Chopra Vikramjit; Michel Jennifer; Hersch Steven M; Ikeda Joh-E; Hayden Michael R
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Human molecular genetics 2002;11(23):2815-28.
2002: See Raymond H; Caday-Malcolm Rosalinda A; Singaraja Roshni R; Zhou Steven; Silverston Anthony; Huber Mary T; Moran Josh; James Erick R; Janoo Rozmin; Savill Jane M; Rigot Veronique; Zhang Lin-Hua; Wang Minghan; Chimini Giovanna; Wellington Cheryl L; Tafuri Sherrie R; Hayden Michael R
Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
The Journal of biological chemistry 2002;277(44):41835-42.
2002: Attie Alan D; Hamon Yannick; Brooks-Wilson Angela R; Gray-Keller Mark P; MacDonald Marcia L E; Rigot Veronique; Tebon Angie; Zhang Lin-Hua; Mulligan Jacob D; Singaraja Roshni R; Bitgood J James; Cook Mark E; Kastelein John J P; Chimini Giovanna; Hayden Michael R
Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.
Journal of lipid research 2002;43(10):1610-7.
2002: Robitaille Johane; MacDonald Marcia L E; Kaykas Ajamete; Sheldahl Laird C; Zeisler Jutta; Dubé Marie-Pierre; Zhang Lin-Hua; Singaraja Roshni R; Guernsey Duane L; Zheng Binyou; Siebert Lee F; Hoskin-Mott Ann; Trese Michael T; Pimstone Simon N; Shastry Barkur S; Moon Randall T; Hayden Michael R; Goldberg Y Paul; Samuels Mark E
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.
Nature genetics 2002;32(2):326-30.
2002: Wellington Cheryl L; Ellerby Lisa M; Gutekunst Claire-Anne; Rogers Danny; Warby Simon; Graham Rona K; Loubser Odell; van Raamsdonk Jeremy; Singaraja Roshni; Yang Yu-Zhou; Gafni Juliette; Bredesen Dale; Hersch Steven M; Leavitt Blair R; Roy Sophie; Nicholson Donald W; Hayden Michael R
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7862-72.
2002: Chan Edmond Y W; Luthi-Carter Ruth; Strand Andrew; Solano Steven M; Hanson Sarah A; DeJohn Molly M; Kooperberg Charles; Chase Kathryn O; DiFiglia Marian; Young Anne B; Leavitt Blair R; Cha Jang-Ho J; Aronin Neil; Hayden Michael R; Olson James M
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Human molecular genetics 2002;11(17):1939-51.
2002: Singaraja Roshni R; Fievet Catherine; Castro Graciela; James Erick R; Hennuyer Nathalie; Clee Susanne M; Bissada Nagat; Choy Jonathan C; Fruchart Jean-Charles; McManus Bruce M; Staels Bart; Hayden Michael R
Increased ABCA1 activity protects against atherosclerosis.
The Journal of clinical investigation 2002;110(1):35-42.
2002: Legendre-Guillemin Valerie; Metzler Martina; Charbonneau Martine; Gan Lu; Chopra Vikramjit; Philie Jacynthe; Hayden Michael R; McPherson Peter S
HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
The Journal of biological chemistry 2002;277(22):19897-904.
2002: Chan Edmond Y W; Nasir Jamal; Gutekunst Claire-Anne; Coleman Sarah; Maclean Alan; Maas Alex; Metzler Martina; Gertsenstein Marina; Ross Christopher A; Nagy Andràs; Hayden Michael R
Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior.
Human molecular genetics 2002;11(8):945-59.
2002: Zeron Melinda M; Hansson Oskar; Chen Nansheng; Wellington Cheryl L; Leavitt Blair R; Brundin Patrik; Hayden Michael R; Raymond Lynn A
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease.
Neuron 2002;33(6):849-60.
2002: Wellington Cheryl L; Walker Elizabeth K Y; Suarez Agripina; Kwok Anita; Bissada Nagat; Singaraja Roshni; Yang Yu-Zhou; Zhang Lin-Hua; James Erick; Wilson Janet E; Francone Omar; McManus Bruce M; Hayden Michael R
ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation.
Laboratory investigation; a journal of technical methods and pathology 2002;82(3):273-83.
2002: Zwarts K Y; Clee S M; Zwinderman A H; Engert J C; Singaraja R; Loubser O; James E; Roomp K; Hudson T J; Jukema J W; Kastelein J J P; Hayden M R
ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.
Clinical genetics 2002;61(2):115-25.
2002: Gervais François G; Singaraja Roshni; Xanthoudakis Steven; Gutekunst Claire-Anne; Leavitt Blair R; Metzler Martina; Hackam Abigail S; Tam John; Vaillancourt John P; Houtzager Vicky; Rasper Dita M; Roy Sophie; Hayden Michael R; Nicholson Donald W
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nature cell biology 2002;4(2):95-105.
2002: van Dam Marjel J; de Groot Eric; Clee Susanne M; Hovingh G Kees; Roelants Roosje; Brooks-Wilson Angie; Zwinderman Aeilko H; Smit Andries J; Smelt August H M; Groen Albert K; Hayden Michael R; Kastelein John J P
Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study.
Lancet 2002;359(9300):37-42.
2002: Nishida Yoshiharu; Hirano Kenichi; Tsukamoto Kosuke; Nagano Makoto; Ikegami Chiaki; Roomp Kirsten; Ishihara Mitsuaki; Sakane Naoki; Zhang Zhongyan; Tsujii Ki Ken-ichi; Matsuyama Akifumi; Ohama Tohru; Matsuura Fumihiko; Ishigami Masato; Sakai Naohiko; Hiraoka Hisatoyo; Hattori Hiroaki; Wellington Cheryl; Yoshida Yoshihide; Misugi Susumu; Hayden Michael R; Egashira Toru; Yamashita Shizuya; Matsuzawa Yuji
Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency.
Biochemical and biophysical research communications 2002;290(2):713-21.
2001: Attie A D; Kastelein J P; Hayden M R
Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis.
Journal of lipid research 2001;42(11):1717-26.
2001: Clee S M; Loubser O; Collins J; Kastelein J J; Hayden M R
The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.
Clinical genetics 2001;60(4):293-300.
2001: Hadano S; Hand C K; Osuga H; Yanagisawa Y; Otomo A; Devon R S; Miyamoto N; Showguchi-Miyata J; Okada Y; Singaraja R; Figlewicz D A; Kwiatkowski T; Hosler B A; Sagie T; Skaug J; Nasir J; Brown R H; Scherer S W; Rouleau G A; Hayden M R; Ikeda J E
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Nature genetics 2001;29(2):166-73.
2001: Metzler M; Legendre-Guillemin V; Gan L; Chopra V; Kwok A; McPherson P S; Hayden M R
HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.
The Journal of biological chemistry 2001;276(42):39271-6.
2001: Almqvist E W; Elterman D S; MacLeod P M; Hayden M R
High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia.
Clinical genetics 2001;60(3):198-205.
2001: Singaraja R R; Bocher V; James E R; Clee S M; Zhang L H; Leavitt B R; Tan B; Brooks-Wilson A; Kwok A; Bissada N; Yang Y Z; Liu G; Tafuri S R; Fievet C; Wellington C L; Staels B; Hayden M R
Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.
The Journal of biological chemistry 2001;276(36):33969-79.
2001: Paulsen J S; Zhao H; Stout J C; Brinkman R R; Guttman M; Ross C A; Como P; Manning C; Hayden M R; Shoulson I;
Clinical markers of early disease in persons near onset of Huntington's disease.
Neurology 2001;57(4):658-62.
2001: Peel A L; Rao R V; Cottrell B A; Hayden M R; Ellerby L M; Bredesen D E
Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.
Human molecular genetics 2001;10(15):1531-8.
2001: Rosenblatt A; Brinkman R R; Liang K Y; Almqvist E W; Margolis R L; Huang C Y; Sherr M; Franz M L; Abbott M H; Hayden M R; Ross C A
Familial influence on age of onset among siblings with Huntington disease.
American journal of medical genetics 2001;105(5):399-403.
2001: Zuccato C; Ciammola A; Rigamonti D; Leavitt B R; Goffredo D; Conti L; MacDonald M E; Friedlander R M; Silani V; Hayden M R; Timmusk T; Sipione S; Cattaneo E
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
Science (New York, N.Y.) 2001;293(5529):493-8.
2001: McGladdery S H; Pimstone S N; Clee S M; Bowden J F; Hayden M R; Frohlich J J
Common mutations in the lipoprotein lipase gene (LPL): effects on HDL-cholesterol levels in a Chinese Canadian population.
Atherosclerosis 2001;156(2):401-7.
2001: Emsley R A; Niehaus D J; Mbanga N I; Oosthuizen P P; Stein D J; Maritz J S; Pimstone S N; Hayden M R; Laurent C; Deleuze J F; Mallet J
The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia.
Schizophrenia research 2001;47(2-3):149-57.
2001: Clee S M; Zwinderman A H; Engert J C; Zwarts K Y; Molhuizen H O; Roomp K; Jukema J W; van Wijland M; van Dam M; Hudson T J; Brooks-Wilson A; Genest J; Kastelein J J; Hayden M R
Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease.
Circulation 2001;103(9):1198-205.
2001: Otto C J; Almqvist E; Hayden M R; Andrew S E
The "flap" endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease.
Clinical genetics 2001;59(2):122-7.
2001: Backus R C; Ginzinger D G; Ashbourne Excoffon K J; Clee S M; Hayden M R; Eckel R H; Hickman M A; Rogers Q R
Maternal expression of functional lipoprotein lipase and effects on body fat mass and body condition scores of mature cats with lipoprotein lipase deficiency.
American journal of veterinary research 2001;62(2):264-9.
2001: Holbert S; Denghien I; Kiechle T; Rosenblatt A; Wellington C; Hayden M R; Margolis R L; Ross C A; Dausset J; Ferrante R J; Néri C
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1811-6.
2001: Leavitt B R; Guttman J A; Hodgson J G; Kimel G H; Singaraja R; Vogl A W; Hayden M R
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
American journal of human genetics 2001;68(2):313-24.
2001: Hadano S; Yanagisawa Y; Skaug J; Fichter K; Nasir J; Martindale D; Koop B F; Scherer S W; Nicholson D W; Rouleau G A; Ikeda J; Hayden M R
Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.
Genomics 2001;71(2):200-13.
2001: Zeron M M; Chen N; Moshaver A; Lee A T; Wellington C L; Hayden M R; Raymond L A
Mutant huntingtin enhances excitotoxic cell death.
Molecular and cellular neurosciences 2001;17(1):41-53.
2000: Hayden M R
Predictive testing for Huntington's disease: the calm after the storm.
Lancet 2000;356(9246):1944-5.
2000: Hackam A S; Yassa A S; Singaraja R; Metzler M; Gutekunst C A; Gan L; Warby S; Wellington C L; Vaillancourt J; Chen N; Gervais F G; Raymond L; Nicholson D W; Hayden M R
Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
The Journal of biological chemistry 2000;275(52):41299-308.
2000: Clee S M; Kastelein J J; van Dam M; Marcil M; Roomp K; Zwarts K Y; Collins J A; Roelants R; Tamasawa N; Stulc T; Suda T; Ceska R; Boucher B; Rondeau C; DeSouich C; Brooks-Wilson A; Molhuizen H O; Frohlich J; Genest J; Hayden M R
Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.
The Journal of clinical investigation 2000;106(10):1263-70.
2000: Chopra V S; Metzler M; Rasper D M; Engqvist-Goldstein A E; Singaraja R; Gan L; Fichter K M; McCutcheon K; Drubin D; Nicholson D W; Hayden M R
HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):1006-15.
2000: Kastelein J J; Jukema J W; Zwinderman A H; Clee S; van Boven A J; Jansen H; Rabelink T J; Peters R J; Lie K I; Liu G; Bruschke A V; Hayden M R
Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group.
Circulation 2000;102(14):1629-33.
2000: Clarke G; Collins R A; Leavitt B R; Andrews D F; Hayden M R; Lumsden C J; McInnes R R
A one-hit model of cell death in inherited neuronal degenerations.
Nature 2000;406(6792):195-9.
2000: Wellington C L; Singaraja R; Ellerby L; Savill J; Roy S; Leavitt B; Cattaneo E; Hackam A; Sharp A; Thornberry N; Nicholson D W; Bredesen D E; Hayden M R
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
The Journal of biological chemistry 2000;275(26):19831-8.
2000: Rigamonti D; Bauer J H; De-Fraja C; Conti L; Sipione S; Sciorati C; Clementi E; Hackam A; Hayden M R; Li Y; Cooper J K; Ross C A; Govoni S; Vincenz C; Cattaneo E
Wild-type huntingtin protects from apoptosis upstream of caspase-3.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3705-13.
2000: Hayden M R; Clee S M; Brooks-Wilson A; Genest J; Attie A; Kastelein J J
Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency.
Current opinion in lipidology 2000;11(2):117-22.
2000: Clee S M; Bissada N; Miao F; Miao L; Marais A D; Henderson H E; Steures P; McManus J; McManus B; LeBoeuf R C; Kastelein J J; Hayden M R
Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis.
Journal of lipid research 2000;41(4):521-31.
2000: Metzler M; Helgason C D; Dragatsis I; Zhang T; Gan L; Pineault N; Zeitlin S O; Humphries R K; Hayden M R
Huntingtin is required for normal hematopoiesis.
Human molecular genetics 2000;9(3):387-94.
2000: Wellington C L; Hayden M R
Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.
Clinical genetics 2000;57(1):1-10.
2000: Liu G; Ashbourne Excoffon K J; Wilson J E; McManus B M; Rogers Q R; Miao L; Kastelein J J; Lewis M E; Hayden M R
Phenotypic correction of feline lipoprotein lipase deficiency by adenoviral gene transfer.
Human gene therapy 2000;11(1):21-32.
2000: Wellington C L; Leavitt B R; Hayden M R
Huntington disease: new insights on the role of huntingtin cleavage.
Journal of neural transmission. Supplementum 2000;(58):1-17.
1999: Engqvist-Goldstein A E; Kessels M M; Chopra V S; Hayden M R; Drubin D G
An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles.
The Journal of cell biology 1999;147(7):1503-18.
1999: Wittekoek M E; Moll E; Pimstone S N; Trip M D; Lansberg P J; Defesche J C; van Doormaal J J; Hayden M R; Kastelein J J
A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2708-13.
1999: Kastelein J J; Ordovas J M; Wittekoek M E; Pimstone S N; Wilson W F; Gagné S E; Larson M G; Schaefer E J; Boer J M; Gerdes C; Hayden M R
Two common mutations (D9N, N291S) in lipoprotein lipase: a cumulative analysis of their influence on plasma lipids and lipoproteins in men and women.
Clinical genetics 1999;56(4):297-305.
1999: Marcil M; Brooks-Wilson A; Clee S M; Roomp K; Zhang L H; Yu L; Collins J A; van Dam M; Molhuizen H O; Loubster O; Ouellette B F; Sensen C W; Fichter K; Mott S; Denis M; Boucher B; Pimstone S; Genest J; Kastelein J J; Hayden M R
Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux.
Lancet 1999;354(9187):1341-6.
1999: Kremer B; Clark C M; Almqvist E W; Raymond L A; Graf P; Jacova C; Mezei M; Hardy M A; Snow B; Martin W; Hayden M R
Influence of lamotrigine on progression of early Huntington disease: a randomized clinical trial.
Neurology 1999;53(5):1000-11.
1999: Brooks-Wilson A; Marcil M; Clee S M; Zhang L H; Roomp K; van Dam M; Yu L; Brewer C; Collins J A; Molhuizen H O; Loubser O; Ouelette B F; Fichter K; Ashbourne-Excoffon K J; Sensen C W; Scherer S; Mott S; Denis M; Martindale D; Frohlich J; Morgan K; Koop B; Pimstone S; Kastelein J J; Genest J; Hayden M R
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency.
Nature genetics 1999;22(4):336-45.
1999: Hadano S; Nasir J; Nichol K; Rasper D M; Vaillancourt J P; Sherer S W; Beatty B G; Ikeda J E; Nicholson D W; Hayden M R
Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(7):757-60.
1999: Gagné S E; Larson M G; Pimstone S N; Schaefer E J; Kastelein J J; Wilson P W; Ordovas J M; Hayden M R
A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study.
Clinical genetics 1999;55(6):450-4.
1999: Hackam A S; Hodgson J G; Singaraja R; Zhang T; Gan L; Gutekunst C A; Hersch S M; Hayden M R
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1047-55.
1999: Hodgson J G; Agopyan N; Gutekunst C A; Leavitt B R; LePiane F; Singaraja R; Smith D J; Bissada N; McCutcheon K; Nasir J; Jamot L; Li X J; Stevens M E; Rosemond E; Roder J C; Phillips A G; Rubin E M; Hersch S M; Hayden M R
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Neuron 1999;23(1):181-92.
1999: Chen N; Luo T; Wellington C; Metzler M; McCutcheon K; Hayden M R; Raymond L A
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.
Journal of neurochemistry 1999;72(5):1890-8.
1999: Almqvist E W; Bloch M; Brinkman R; Craufurd D; Hayden M R
A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease.
American journal of human genetics 1999;64(5):1293-304.
1999: Henderson H E; Kastelein J J; Zwinderman A H; Gagné E; Jukema J W; Reymer P W; Groenemeyer B E; Lie K I; Bruschke A V; Hayden M R; Jansen H
Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins.
Journal of lipid research 1999;40(4):735-43.
1999: Nasir J; Maclean A; Engelender S; Duan K; Margolis R L; Kleiderlein J J; Ross C A; Hayden M R
Chromosomal localization of the Huntingtin associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):397-8.
1999: Bruland O; Almqvist E W; Goldberg Y P; Boman H; Hayden M R; Knappskog P M
Accurate determination of the number of CAG repeats in the Huntington disease gene using a sequence-specific internal DNA standard.
Clinical genetics 1999;55(3):198-202.
1999: Ellerby L M; Andrusiak R L; Wellington C L; Hackam A S; Propp S S; Wood J D; Sharp A H; Margolis R L; Ross C A; Salvesen G S; Hayden M R; Bredesen D E
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
The Journal of biological chemistry 1999;274(13):8730-6.
1999: Metzler M; Chen N; Helgason C D; Graham R K; Nichol K; McCutcheon K; Nasir J; Humphries R K; Raymond L A; Hayden M R
Life without huntingtin: normal differentiation into functional neurons.
Journal of neurochemistry 1999;72(3):1009-18.
1999: O'Kusky J R; Nasir J; Cicchetti F; Parent A; Hayden M R
Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene.
Brain research 1999;818(2):468-79.
1999: Ginzinger D G; Clee S M; Dallongeville J; Lewis M E; Henderson H E; Bauje E; Rogers Q R; Jensen D R; Eckel R H; Dyer R; Innis S; Jones B; Fruchart J C; Hayden M R
Lipid and lipoprotein analysis of cats with lipoprotein lipase deficiency.
European journal of clinical investigation 1999;29(1):17-26.
1999: Hadano S; Nichol K; Brinkman R R; Nasir J; Martindale D; Koop B F; Nicholson D W; Scherer S W; Ikeda J E; Hayden M R
A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
Genomics 1999;55(1):106-12.
1999: Hackam A S; Singaraja R; Zhang T; Gan L; Hayden M R
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
Human molecular genetics 1999;8(1):25-33.
1999: Ellerby L M; Hackam A S; Propp S S; Ellerby H M; Rabizadeh S; Cashman N R; Trifiro M A; Pinsky L; Wellington C L; Salvesen G S; Hayden M R; Bredesen D E
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
Journal of neurochemistry 1999;72(1):185-95.
1999: Leavitt B R; Wellington C L; Hayden M R
Recent insights into the molecular pathogenesis of Huntington disease.
Seminars in neurology 1999;19(4):385-95.
1999: Kim M; Velier J; Chase K; Laforet G; Kalchman M A; Hayden M R; Won L; Heller A; Aronin N; Difiglia M
Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.
Neuroscience 1999;89(4):1159-67.
1998: Hayden M R
In vitro and in vivo models for Huntington disease: lessons for the polyglutamine expansion disorders.
Pathologie-biologie 1998;46(9):695-6.
1998: Liu G; Excoffon K J; Wilson J E; McManus B M; Miao L; Benoit P; Duverger N; Branellec D; Denefle P; Hayden M R; Lewis M E
Enhanced lipolysis in normal mice expressing liver-derived human lipoprotein lipase after adenoviral gene transfer.
Clinical and investigative medicine. Médecine clinique et experimentale 1998;21(4-5):172-85.
1998: Henderson H E; Bijvoet S M; Mannens M A; Bruin T; Erkelens D W; Hayden M R; Kastelein J J
Ile225Thr loop mutation in the lipoprotein lipase (LPL) gene is a de novo event.
American journal of medical genetics 1998;78(4):313-6.
1998: Nasir J; Duan K; Nichol K; Engelender S; Ashworth R; Colomer V; Thomas S; Disteche C M; Hayden M R; Ross C A
Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(7):565-70.
1998: Hackam A S; Singaraja R; Wellington C L; Metzler M; McCutcheon K; Zhang T; Kalchman M; Hayden M R
The influence of huntingtin protein size on nuclear localization and cellular toxicity.
The Journal of cell biology 1998;141(5):1097-105.
1998: Rasper D M; Vaillancourt J P; Hadano S; Houtzager V M; Seiden I; Keen S L; Tawa P; Xanthoudakis S; Nasir J; Martindale D; Koop B F; Peterson E P; Thornberry N A; Huang J; MacPherson D P; Black S C; Hornung F; Lenardo M J; Hayden M R; Roy S; Nicholson D W
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
Cell death and differentiation 1998;5(4):271-88.
1998: Hackam A S; Wellington C L; Hayden M R
The fatal attraction of polyglutamine-containing proteins.
Clinical genetics 1998;53(4):233-42.
1998: Wellington C L; Ellerby L M; Hackam A S; Margolis R L; Trifiro M A; Singaraja R; McCutcheon K; Salvesen G S; Propp S S; Bromm M; Rowland K J; Zhang T; Rasper D; Roy S; Thornberry N; Pinsky L; Kakizuka A; Ross C A; Nicholson D W; Bredesen D E; Hayden M R
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
1998: Wittekoek M E; Pimstone S N; Reymer P W; Feuth L; Botma G J; Defesche J C; Prins M; Hayden M R; Kastelein J J
A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia.
Circulation 1998;97(8):729-35.
1998: Pimstone S N; Sun X M; du Souich C; Frohlich J J; Hayden M R; Soutar A K
Phenotypic variation in heterozygous familial hypercholesterolemia: a comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):309-15.
1998: Martindale D; Hackam A; Wieczorek A; Ellerby L; Wellington C; McCutcheon K; Singaraja R; Kazemi-Esfarjani P; Devon R; Kim S U; Bredesen D E; Tufaro F; Hayden M R
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.
Nature genetics 1998;18(2):150-4.
1998: Kastelein J J; Groenemeyer B E; Hallman D M; Henderson H; Reymer P W; Gagné S E; Jansen H; Seidell J C; Kromhout D; Jukema J W; Bruschke A V; Boerwinkle E; Hayden M R
The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group.
Clinical genetics 1998;53(1):27-33.
1998: Foubert L; De Gennes J L; Benlian P; Truffert J; Miao L; Hayden M R
Compound heterozygosity for frameshift mutations in the gene for lipoprotein lipase in a patient with early-onset chylomicronemia.
Human mutation 1998;Suppl 1():S141-4.
1997: Abdel-Wareth L O; Pimstone S N; Lagarde J P; Raisonnier A; Benlian P; Pritchard H; Hayden M R; Frohlich J J
Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: identification of a unique haplotype of the apolipoprotein B-100 allele.
Atherosclerosis 1997;135(2):181-5.
1997: Ehrenborg E; Clee S M; Pimstone S N; Reymer P W; Benlian P; Hoogendijk C F; Davis H J; Bissada N; Miao L; Gagné S E; Greenberg L J; Henry R; Henderson H; Ordovas J M; Schaefer E J; Kastelein J J; Kotze M J; Hayden M R
Ethnic variation and in vivo effects of the -93t-->g promoter variant in the lipoprotein lipase gene.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2672-8.
1997: Excoffon K J; Liu G; Miao L; Wilson J E; McManus B M; Semenkovich C F; Coleman T; Benoit P; Duverger N; Branellec D; Denefle P; Hayden M R; Lewis M E
Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2532-9.
1997: Ginzinger D G; Wilson J E; Redenbach D; Lewis M E; Clee S M; Excoffon K J; Rogers Q R; Hayden M R; McManus B M
Diet-induced atherosclerosis in the domestic cat.
Laboratory investigation; a journal of technical methods and pathology 1997;77(5):409-19.
1997: Andrew S E; Goldberg Y P; Hayden M R
Rethinking genotype and phenotype correlations in polyglutamine expansion disorders.
Human molecular genetics 1997;6(12):2005-10.
1997: Almqvist E; Adam S; Bloch M; Fuller A; Welch P; Eisenberg D; Whelan D; Macgregor D; Meschino W; Hayden M R
Risk reversals in predictive testing for Huntington disease.
American journal of human genetics 1997;61(4):945-52.
1997: Clee S M; Zhang H; Bissada N; Miao L; Ehrenborg E; Benlian P; Shen G X; Angel A; LeBoeuf R C; Hayden M R
Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: modulation by cholesteryl ester transfer protein and dietary status.
Journal of lipid research 1997;38(10):2079-89.
1997: Foubert L; De Gennes J L; Lagarde J P; Ehrenborg E; Raisonnier A; Girardet J P; Hayden M R; Benlian P
Assessment of French patients with LPL deficiency for French Canadian mutations.
Journal of medical genetics 1997;34(8):672-5.
1997: Wellington C L; Hayden M R
Of molecular interactions, mice and mechanisms: new insights into Huntington's disease.
Current opinion in neurology 1997;10(4):291-8.
1997: Nasir J; Theilmann J L; Vaillancourt J P; Munday N A; Ali A; Scherer S; Beatty B; Nicholson D W; Hayden M R
Interleukin-1beta-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(8):611-3.
1997: Burgess M M; Adam S; Bloch M; Hayden M R
Dilemmas of anonymous predictive testing for Huntington disease: privacy vs. optimal care.
American journal of medical genetics 1997;71(2):197-201.
1997: Wellington C L; Brinkman R R; O'Kusky J R; Hayden M R
Toward understanding the molecular pathology of Huntington's disease.
Brain pathology (Zurich, Switzerland) 1997;7(3):979-1002.
1997: Groenemeijer B E; Hallman M D; Reymer P W; Gagné E; Kuivenhoven J A; Bruin T; Jansen H; Lie K I; Bruschke A V; Boerwinkle E; Hayden M R; Kastelein J J
Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. REGRESS Study Group.
Circulation 1997;95(12):2628-35.
1997: Pimstone S N; Defesche J C; Clee S M; Bakker H D; Hayden M R; Kastelein J J
Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(5):826-33.
1997: Brinkman R R; Mezei M M; Theilmann J; Almqvist E; Hayden M R
The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size.
American journal of human genetics 1997;60(5):1202-10.
1997: Kalchman M A; Koide H B; McCutcheon K; Graham R K; Nichol K; Nishiyama K; Kazemi-Esfarjani P; Lynn F C; Wellington C; Metzler M; Goldberg Y P; Kanazawa I; Gietz R D; Hayden M R
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.
Nature genetics 1997;16(1):44-53.
1997: Goellner G M; Tester D; Thibodeau S; Almqvist E; Goldberg Y P; Hayden M R; McMurray C T
Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer.
American journal of human genetics 1997;60(4):879-90.
1997: Chong S S; Almqvist E; Telenius H; LaTray L; Nichol K; Bourdelat-Parks B; Goldberg Y P; Haddad B R; Richards F; Sillence D; Greenberg C R; Ives E; Van den Engh G; Hughes M R; Hayden M R
Contribution of DNA sequence and CAG size to mutation frequencies of intermediate alleles for Huntington disease: evidence from single sperm analyses.
Human molecular genetics 1997;6(2):301-9.
1997: Nasir J; Theilmann J L; Chopra V; Jones A M; Walker D; Rasper D M; Vaillancourt J P; Hewitt J E; Nicholson D W; Hayden M R
Localization of the cell death genes CPP32 and Mch-2 to human chromosome 4q.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(1):56-9.
1997: Liu G; Excoffon K J; Benoit P; Ginzinger D G; Miao L; Ehrenborg E; Duverger N; Denefle P P; Hayden M R; Lewis M E
Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells.
Human gene therapy 1997;8(2):205-14.
1996: Hodgson J G; Smith D J; McCutcheon K; Koide H B; Nishiyama K; Dinulos M B; Stevens M E; Bissada N; Nasir J; Kanazawa I; Disteche C M; Rubin E M; Hayden M R
Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype.
Human molecular genetics 1996;5(12):1875-85.
1996: Bijvoet S M; Wiebusch H; Ma Y; Reymer P W; Bruin T; Bakker H D; Funke H; Assmann G; Hayden M R; Kastelein J J
Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency.
The Netherlands journal of medicine 1996;49(5):189-95.
1996: Wiggins S; Green T; Adam S; Hayden M R
A long term (ca 5 years) prospective assessment of psychological consequences of predictive testing for Huntington disease (HD)
American journal of human genetics 1996;59(4):A7.
1996: Lawson K; Wiggins S; Green T; Adam S; Bloch M; Hayden M R
Adverse psychological events occurring in the first year after predictive testing for Huntington's disease. The Canadian Collaborative Study Predictive Testing.
Journal of medical genetics 1996;33(10):856-62.
1996: Jukema J W; van Boven A J; Groenemeijer B; Zwinderman A H; Reiber J H; Bruschke A V; Henneman J A; Molhoek G P; Bruin T; Jansen H; Gagné E; Hayden M R; Kastelein J J
The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study.
Circulation 1996;94(8):1913-8.
1996: Henderson H E; Hassan F; Marais D; Hayden M R
A new mutation destroying disulphide bridging in the C-terminal domain of lipoprotein lipase.
Biochemical and biophysical research communications 1996;227(1):189-94.
1996: Pimstone S N; Clee S M; Gagné S E; Miao L; Zhang H; Stein E A; Hayden M R
A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers.
Journal of lipid research 1996;37(8):1675-84.
1996: Kalchman M A; Graham R K; Xia G; Koide H B; Hodgson J G; Graham K C; Goldberg Y P; Gietz R D; Pickart C M; Hayden M R
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.
The Journal of biological chemistry 1996;271(32):19385-94.
1996: Goldberg Y P; Nicholson D W; Rasper D M; Kalchman M A; Koide H B; Graham R K; Bromm M; Kazemi-Esfarjani P; Thornberry N A; Vaillancourt J P; Hayden M R
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.
Nature genetics 1996;13(4):442-9.
1996: Zhang H; Henderson H; Gagne S E; Clee S M; Miao L; Liu G; Hayden M R
Common sequence variants of lipoprotein lipase: standardized studies of in vitro expression and catalytic function.
Biochimica et biophysica acta 1996;1302(2):159-66.
1996: Defesche J C; Van Diermen D E; Hayden M R; Kastelein J P
Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia.
Gene geography : a computerized bulletin on human gene frequencies 1996;10(1):1-10.
1996: Bijvoet S; Gagné S E; Moorjani S; Gagné C; Henderson H E; Fruchart J C; Dallongeville J; Alaupovic P; Prins M; Kastelein J J; Hayden M R
Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency.
Journal of lipid research 1996;37(3):640-50.
1996: Goldberg Y P; Kalchman M A; Metzler M; Nasir J; Zeisler J; Graham R; Koide H B; O'Kusky J; Sharp A H; Ross C A; Jirik F; Hayden M R
Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript.
Human molecular genetics 1996;5(2):177-85.
1996: Nasir J; Goldberg Y P; Hayden M R
Huntington disease: new insights into the relationship between CAG expansion and disease.
Human molecular genetics 1996;5 Spec No():1431-5.
1995: Krapp A; Zhang H; Ginzinger D; Liu M S; Lindberg A; Olivecrona G; Hayden M R; Beisiegel U
Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells.
Journal of lipid research 1995;36(11):2362-73.
1995: Goldberg Y P; McMurray C T; Zeisler J; Almqvist E; Sillence D; Richards F; Gacy A M; Buchanan J; Telenius H; Hayden M R
Increased instability of intermediate alleles in families with sporadic Huntington disease compared to similar sized intermediate alleles in the general population.
Human molecular genetics 1995;4(10):1911-8.
1995: Zhang H; Reymer P W; Liu M S; Forsythe I J; Groenemeyer B E; Frohlich J; Brunzell J D; Kastelein J J; Hayden M R; Ma Y
Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291-->Ser mutation in the human LPL gene.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1695-703.
1995: Andrew S E; Hayden M R
Origins and evolution of Huntington disease chromosomes.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1995;4(3):239-44.
1995: Kremer B; Almqvist E; Theilmann J; Spence N; Telenius H; Goldberg Y P; Hayden M R
Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes.
American journal of human genetics 1995;57(2):343-50.
1995: Lewis M E; Forsythe I J; Marth J D; Brunzell J D; Hayden M R; Humphries R K
Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells.
Human gene therapy 1995;6(7):853-63.
1995: Copley T T; Wiggins S; Dufrasne S; Bloch M; Adam S; McKellin W; Hayden M R
Are we all of one mind? Clinicians' and patients' opinions regarding the development of a service protocol for predictive testing for Huntington disease. Canadian Collaborative Study for Predictive Testing for Huntington Disease.
American journal of medical genetics 1995;58(1):59-69.
1995: Nasir J; Floresco S B; O'Kusky J R; Diewert V M; Richman J M; Zeisler J; Borowski A; Marth J D; Phillips A G; Hayden M R
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
Cell 1995;81(5):811-23.
1995: Leung P C; Squire J; Peng C; Fan N; Hayden M R; Olofsson J I
Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(4):309-10.
1995: Lin B; Nasir J; Kalchman M A; McDonald H; Zeisler J; Goldberg Y P; Hayden M R
Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms.
Genomics 1995;25(3):707-15.
1995: Lin B; Nasir J; McDonald H; Graham R; Rommens J M; Goldberg Y P; Hayden M R
Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms.
Genomics 1995;25(1):93-9.
1995: Hayden M R; Reidy M
Many roads lead to atheroma.
Nature medicine 1995;1(1):22-3.
1995: Hayden M R; Bloch M; Wiggins S
Psychological effects of predictive testing for Huntington's disease.
Advances in neurology 1995;65():201-10.
1994: Shinotoh H; Calne D B; Snow B; Hayward M; Kremer B; Theilmann J; Hayden M R
Normal CAG repeat length in the Huntington's disease gene in senile chorea.
Neurology 1994;44(11):2183-4.
1994: Ma Y; Henderson H E; Liu M S; Zhang H; Forsythe I J; Clarke-Lewis I; Hayden M R; Brunzell J D
Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase.
Journal of lipid research 1994;35(11):2049-59.
1994: Clarke L A; Nasir J; Zhang H; McDonald H; Applegarth D A; Hayden M R; Toone J
Murine alpha-L-iduronidase: cDNA isolation and expression.
Genomics 1994;24(2):311-6.
1994: Gagné E; Genest J; Zhang H; Clarke L A; Hayden M R
Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1250-7.
1994: Goldberg Y P; Telenius H; Hayden M R
The molecular genetics of Huntington's disease.
Current opinion in neurology 1994;7(4):325-32.
1994: Tuzgöl S; Bijvoet S M; Bruin T; Kastelein J J; Hayden M R
Apolipoprotein CII-Padova (Tyr37-->stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana.
Journal of medical genetics 1994;31(8):622-6.
1994: Hayden M R; Liu M S; Ma Y
Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase.
Clinical genetics 1994;46(1 Spec No):15-8.
1994: Nasir J; Lin B; Bucan M; Koizumi T; Nadeau J H; Hayden M R
The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3.
Genomics 1994;22(1):198-201.
1994: Ma Y; Ooi T C; Liu M S; Zhang H; McPherson R; Edwards A L; Forsythe I J; Frohlich J; Brunzell J D; Hayden M R
High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: possible association with apolipoprotein E2 isoform.
Journal of lipid research 1994;35(6):1066-75.
1994: Bijvoet S M; Bruin T; Tuzgöl S; Bakker H D; Hayden M R; Kastelein J J
Homozygosity for a mutation in the lipoprotein lipase gene (Gly139-->Ser) causes chylomicronaemia in a boy of Spanish descent.
Human genetics 1994;93(3):339-43.
1994: Bruin T; Tuzgöl S; Mulder W J; van den Ende A E; Jansen H; Hayden M R; Kastelein J J
A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression.
Journal of lipid research 1994;35(3):438-45.
1994: Davignon J; Roederer G; Montigny M; Hayden M R; Tan M H; Connelly P W; Hegele R; McPherson R; Lupien P J; Gagné C
Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia.
The American journal of cardiology 1994;73(5):339-45.
1994: Lin B; Nasir J; MacDonald H; Hutchinson G; Graham R K; Rommens J M; Hayden M R
Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat [corrected]
Human molecular genetics 1994;3(1):85-92.
1994: Andrew S E; Goldberg Y P; Theilmann J; Zeisler J; Hayden M R
A CCG repeat polymorphism adjacent to the CAG repeat in the Huntington disease gene: implications for diagnostic accuracy and predictive testing.
Human molecular genetics 1994;3(1):65-7.
1994: Karlinsky H; Sadovnick A D; Burgess M M; Langlois S; Hayden M R; Berg J M
Issues in molecular genetic testing of individuals with suspected early-onset familial Alzheimer's disease.
Alzheimer disease and associated disorders 1994;8(2):116-25.
1993: Bruin T; Tuzgöl S; van Diermen D E; Hoogerbrugge-van der Linden N; Brunzell J D; Hayden M R; Kastelein J J
Recurrent pancreatitis and chylomicronemia in an extended Dutch kindred is caused by a Gly154-->Ser substitution in lipoprotein lipase.
Journal of lipid research 1993;34(12):2109-19.
1993: Kremer B; Squitieri F; Telenius H; Andrew S E; Theilmann J; Spence N; Goldberg Y P; Hayden M R
Molecular analysis of late onset Huntington's disease.
Journal of medical genetics 1993;30(12):991-5.
1993: Goldberg Y P; Andrew S E; Theilmann J; Kremer B; Squitieri F; Telenius H; Brown J D; Hayden M R
Familial predisposition to recurrent mutations causing Huntington's disease: genetic risk to sibs of sporadic cases.
Journal of medical genetics 1993;30(12):987-90.
1993: Defesche J C; van Diermen D E; Lansberg P J; Lamping R J; Reymer P W; Hayden M R; Kastelein J J
South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population.
Human genetics 1993;92(6):567-70.
1993: Babul R; Adam S; Kremer B; Dufrasne S; Wiggins S; Huggins M; Theilmann J; Bloch M; Hayden M R
Attitudes toward direct predictive testing for the Huntington disease gene. Relevance for other adult-onset disorders. The Canadian Collaborative Group on Predictive Testing for Huntington Disease.
JAMA : the journal of the American Medical Association 1993;270(19):2321-5.
1993: Defesche J C; Pricker K L; Hayden M R; van der Ende B E; Kastelein J J
Familial defective apolipoprotein B-100 is clinically indistinguishable from familial hypercholesterolemia.
Archives of internal medicine 1993;153(20):2349-56.
1993: Lin B; Rommens J M; Graham R K; Kalchman M; MacDonald H; Nasir J; Delaney A; Goldberg Y P; Hayden M R
Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression.
Human molecular genetics 1993;2(10):1541-5.
1993: Henderson H E; Ma Y; Liu M S; Clark-Lewis I; Maeder D L; Kastelein J J; Brunzell J D; Hayden M R
Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region.
Journal of lipid research 1993;34(9):1593-602.
1993: Hayden M R; Josephson R
Development of a program for identification of patients with familial hypercholesterolemia in British Columbia: a model for prevention of coronary disease.
The American journal of cardiology 1993;72(10):25D-29D.
1993: Bloch M; Adam S; Fuller A; Kremer B; Welch J P; Wiggins S; Whyte P; Huggins M; Theilmann J; Hayden M R
Diagnosis of Huntington disease: a model for the stages of psychological response based on experience of a predictive testing program.
American journal of medical genetics 1993;47(3):368-74.
1993: Collins C; Duff C; Duncan A M; Planells-Cases R; Sun W; Norremolle A; Michaelis E; Montal M; Worton R; Hayden M R
Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively.
Genomics 1993;17(1):237-9.
1993: Hutchinson G B; Andrew S E; McDonald H; Goldberg Y P; Graham R; Rommens J M; Hayden M R
An Alu element retroposition in two families with Huntington disease defines a new active Alu subfamily.
Nucleic acids research 1993;21(15):3379-83.
1993: Ma Y; Liu M S; Zhang H; Forsythe I J; Brunzell J D; Hayden M R
A 4 basepair deletion in exon 4 of the human lipoprotein lipase gene results in type I hyperlipoproteinemia.
Human molecular genetics 1993;2(7):1049-50.
1993: Weber B; Riess O; Daneshvar H; Graham R; Hayden M R
(CA)n-dinucleotide repeat at the PDEB locus in 4p16.3.
Human molecular genetics 1993;2(6):827.
1993: Andrew S; Theilmann J; Almqvist E; Norremolle A; Lucotte G; Anvret M; Sorensen S A; Turpin J C; Hayden M R
DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease.
Clinical genetics 1993;43(6):286-94.
1993: Goldberg Y P; Andrew S E; Clarke L A; Hayden M R
A PCR method for accurate assessment of trinucleotide repeat expansion in Huntington disease.
Human molecular genetics 1993;2(6):635-6.
1993: Ma Y; Liu M S; Ginzinger D; Frohlich J; Brunzell J D; Hayden M R
Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene.
The Journal of clinical investigation 1993;91(5):1953-8.
1993: Hayden M R
On planting alfalfa and growing orchids: the cloning of the gene causing Huntington disease.
Clinical genetics 1993;43(5):217-22.
1993: Hayden M R; Kastelein J J; Funke H; Brunzell J D; Ma Y
Phenotypic variation of mutations in the human lipoprotein-lipase gene.
Biochemical Society transactions 1993;21(2):506-9.
1993: Durbach N; Hayden M R
George Huntington: the man behind the eponym.
Journal of medical genetics 1993;30(5):406-9.
1993: Zambon A; Torres A; Bijvoet S; Gagne C; Moorjani S; Lupien P J; Hayden M R; Brunzell J D
Prevention of raised low-density lipoprotein cholesterol in a patient with familial hypercholesterolaemia and lipoprotein lipase deficiency.
Lancet 1993;341(8853):1119-21.
1993: McGeer E G; Kremer B; Hayden M R
Monoamines and their metabolites in Huntington's disease brain: evidence for decreased catechol-O-methyltransferase activity.
Biological psychiatry 1993;33(7):551-3.
1993: Tooyama I; Kremer H P; Hayden M R; Kimura H; McGeer E G; McGeer P L
Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease.
Brain research 1993;610(1):1-7.
1992: Defesche J C; van de Ree M A; Kastelein J J; van Diermen D E; Janssens N W; van Doormaal J J; Hayden M R
Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada.
Clinical genetics 1992;42(6):273-80.
1992: Collins C; Schappert K; Hayden M R
The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates.
Human molecular genetics 1992;1(9):727-33.
1992: Wiggins S; Whyte P; Huggins M; Adam S; Theilmann J; Bloch M; Sheps S B; Schechter M T; Hayden M R
The psychological consequences of predictive testing for Huntington's disease. Canadian Collaborative Study of Predictive Testing.
The New England journal of medicine 1992;327(20):1401-5.
1992: Weber B; Riess O; Wolff G; Andrew S; Collins C; Graham R; Theilmann J; Hayden M R
Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.
Nature genetics 1992;2(3):216-22.
1992: Kremer B; Weber B; Hayden M R
New insights into the clinical features, pathogenesis and molecular genetics of Huntington disease.
Brain pathology (Zurich, Switzerland) 1992;2(4):321-35.
1992: Riess O; Noerremoelle A; Weber B; Musarella M A; Hayden M R
The search for mutations in the gene for the beta subunit of the cGMP phosphodiesterase (PDEB) in patients with autosomal recessive retinitis pigmentosa.
American journal of human genetics 1992;51(4):755-62.
1992: Bijvoet S M; Hayden M R
Mismatch PCR: a rapid method to screen for the Pro207-->Leu mutation in the lipoprotein lipase (LPL) gene.
Human molecular genetics 1992;1(7):541.
1992: Bruin T; Kastelein J J; Van Diermen D E; Ma Y; Henderson H E; Stuyt P M; Stalenhoef A F; Sturk A; Brunzell J D; Hayden M R
A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity.
European journal of biochemistry / FEBS 1992;208(2):267-72.
1992: Liu M S; Ma Y; Hayden M R; Brunzell J D
Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activity.
Biochimica et biophysica acta 1992;1128(1):113-5.
1992: Riess O; Weber B; Hayden M R
(CA)n-dinucleotide repeat polymorphism at the locus for the alpha2C adrenergic receptor (ADRA2C) on 4p16.
Human molecular genetics 1992;1(6):452.
1992: Hayden M R; Ma Y
Molecular genetics of human lipoprotein lipase deficiency.
Molecular and cellular biochemistry 1992;113(2):171-6.
1992: Collins C; Hutchinson G; Kowbel D; Riess O; Weber B; Hayden M R
The human beta-subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal cDNA sequence and evidence for expression in brain.
Genomics 1992;13(3):698-704.
1992: Hutchinson G B; Hayden M R
The prediction of exons through an analysis of spliceable open reading frames.
Nucleic acids research 1992;20(13):3453-62.
1992: Andrew S; Theilmann J; Hedrick A; Mah D; Weber B; Hayden M R
Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.
Genomics 1992;13(2):301-11.
1992: Riess O; Noerremoelle A; Collins C; Mah D; Weber B; Hayden M R
Exclusion of DNA changes in the beta-subunit of the c-GMP phosphodiesterase gene as the cause for Huntington's disease.
Nature genetics 1992;1(2):104-8.
1992: Bloch M; Adam S; Wiggins S; Huggins M; Hayden M R
Predictive testing for Huntington disease in Canada: the experience of those receiving an increased risk.
American journal of medical genetics 1992;42(4):499-507.
1992: Henderson H E; Hassan F; Berger G M; Hayden M R
The lipoprotein lipase Gly188----Glu mutation in South Africans of Indian descent: evidence suggesting common origins and an increased frequency.
Journal of medical genetics 1992;29(2):119-22.
1992: Weber B; Hedrick A; Andrew S; Riess O; Collins C; Kowbel D; Hayden M R
Isolation and characterization of new highly polymorphic DNA markers from the Huntington disease region.
American journal of human genetics 1992;50(2):382-93.
1992: Ma Y H; Bruin T; Tuzgol S; Wilson B I; Roederer G; Liu M S; Davignon J; Kastelein J J; Brunzell J D; Hayden M R
Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis.
The Journal of biological chemistry 1992;267(3):1918-23.
1992: Martin W R; Clark C; Ammann W; Stoessl A J; Shtybel W; Hayden M R
Cortical glucose metabolism in Huntington's disease.
Neurology 1992;42(1):223-9.
1992: Dionne C; Gagné C; Julien P; Murthy M R; Lambert M; Roederer G; Davignon J; Hayden M R; Lupien P J; de Braekeleer M
Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Québec, Canada).
Annales de génétique 1992;35(2):89-92.
1992: Riess O; Weber B; Noeremolle A; Shaikh R A; Hayden M R; Musarella M A
Linkage studies and mutation analysis of the PDEB gene in 23 families with Leber congenital amaurosis.
Human mutation 1992;1(6):478-85.
1991: Weber B; Collins C; Kowbel D; Riess O; Hayden M R
Identification of multiple CpG islands and associated conserved sequences in a candidate region for the Huntington disease gene.
Genomics 1991;11(4):1113-24.
1991: Weber B; Riess O; Hutchinson G; Collins C; Lin B Y; Kowbel D; Andrew S; Schappert K; Hayden M R
Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3.
Nucleic acids research 1991;19(22):6263-8.
1991: Greenberg L J; Martell R W; Theilman J; Hayden M R; Joubert J
Genetic linkage between Huntington disease and the D4S10 locus in South African families: further evidence against non-allelic heterogeneity.
Human genetics 1991;87(6):701-8.
1991: Henderson H E; Ma Y; Hassan M F; Monsalve M V; Marais A D; Winkler F; Gubernator K; Peterson J; Brunzell J D; Hayden M R
Amino acid substitution (Ile194----Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands. Support for a multicentric origin.
The Journal of clinical investigation 1991;87(6):2005-11.
1991: Weber B; Riess O; Kreklywich C N; Wood S; Hayden M R
A polymorphic DNA marker at the D8S131 locus.
Nucleic acids research 1991;19(7):1725.
1991: Weber B; Riess O; Hayden M R
A polymorphic DNA marker at the D10S106 locus.
Nucleic acids research 1991;19(7):1725.
1991: Hill J S; Hayden M R; Frohlich J; Pritchard P H
Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(2):290-7.
1991: Clark C M; Ammann W; Martin W R; Ty P; Hayden M R
The FDG/PET methodology for early detection of disease onset: a statistical model.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(2):A96-102.
1991: Weber B; Allen L; Magenis R E; Goodfellow P J; Smith L; Hayden M R
Intrachromosomal location of the telomeric repeat (TTAGGG)n.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(4):211-6.
1991: Weber B; Allen L; Magenis R E; Hayden M R
A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini.
Cytogenetics and cell genetics 1991;57(4):179-83.
1990: Henderson H E; Devlin R; Peterson J; Brunzell J D; Hayden M R
Frameshift mutation in exon 3 of the lipoprotein lipase gene causes a premature stop codon and lipoprotein lipase deficiency.
Molecular biology & medicine 1990;7(6):511-7.
1990: Peritz L N; Brunzell J D; Harvey-Clarke C; Pritchard P H; Jones B R; Hayden M R
Characterization of a lipoprotein lipase class III type defect in hypertriglyceridemic cats.
Clinical and investigative medicine. Médecine clinique et experimentale 1990;13(5):259-63.
1990: Weber B; Collins C; Robbins C; Magenis R E; Delaney A D; Gray J W; Hayden M R
Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n.
Nucleic acids research 1990;18(11):3353-61.
1990: Kastelein J J; Haines J L; Hayden M R
The gene causing familial hypoalphalipoproteinemia is not caused by a defect in the apo AI-CIII-AIV gene cluster in a Spanish family.
Human genetics 1990;84(5):396-400.
1990: Devlin R H; Deeb S; Brunzell J; Hayden M R
Partial gene duplication involving exon-Alu interchange results in lipoprotein lipase deficiency.
American journal of human genetics 1990;46(1):112-9.
1990: Bloch M; Hayden M R
Opinion: predictive testing for Huntington disease in childhood: challenges and implications.
American journal of human genetics 1990;46(1):1-4.
1989: Lowry R B; Wood B J; Cox T A; Hayden M R
Epiphyseal dysplasia, microcephaly, nystagmus, and retinitis pigmentosa.
American journal of medical genetics 1989;33(3):341-5.
1989: Fahy M; Robbins C; Bloch M; Turnell R W; Hayden M R
Different options for prenatal testing for Huntington's disease using DNA probes.
Journal of medical genetics 1989;26(6):353-7.
1989: Chitayat D; Davis E B; McGillivray B C; Hayden M R; Hall J G
Perinatal and first year follow-up of patients with Prader-Willi syndrome: normal size of hands and feet.
Clinical genetics 1989;35(3):161-6.
1989: Robbins C; Theilmann J; Youngman S; Haines J; Altherr M J; Harper P S; Payne C; Junker A; Wasmuth J; Hayden M R
Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.
American journal of human genetics 1989;44(3):422-5.
1989: Langlois S; Deeb S; Brunzell J D; Kastelein J J; Hayden M R
A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):948-52.
1989: Bloch M; Fahy M; Fox S; Hayden M R
Predictive testing for Huntington disease: II. Demographic characteristics, life-style patterns, attitudes, and psychosocial assessments of the first fifty-one test candidates.
American journal of medical genetics 1989;32(2):217-24.
1989: Fox S; Bloch M; Fahy M; Hayden M R
Predictive testing for Huntington disease: I. Description of a pilot project in British Columbia.
American journal of medical genetics 1989;32(2):211-6.
1988: Hayden M R; Robbins C; Allard D; Haines J; Fox S; Wasmuth J; Fahy M; Bloch M
Improved predictive testing for Huntington disease by using three linked DNA markers.
American journal of human genetics 1988;43(5):689-94.
1988: Lam R W; Bloch M; Jones B D; Marcus A M; Fox S; Amman W; Hayden M R
Psychiatric morbidity associated with early clinical diagnosis of Huntington disease in a predictive testing program.
The Journal of clinical psychiatry 1988;49(11):444-7.
1988: Hayden M R; Bloch M; Fahy M
Predictive testing for Huntington's disease using linked DNA markers.
The New England journal of medicine 1988;319(9):583-4.
1988: Jason G W; Pajurkova E M; Suchowersky O; Hewitt J; Hilbert C; Reed J; Hayden M R
Presymptomatic neuropsychological impairment in Huntington's disease.
Archives of neurology 1988;45(7):769-73.
1988: Langlois S; Kastelein J J; Hayden M R
Characterization of six partial deletions in the low-density-lipoprotein (LDL) receptor gene causing familial hypercholesterolemia (FH).
American journal of human genetics 1988;43(1):60-8.
1988: Hayden M R; Hewitt J; Wasmuth J J; Kastelein J J; Langlois S; Conneally M; Haines J; Smith B; Hilbert C; Allard D
A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene.
American journal of human genetics 1988;42(1):125-31.
1987: Hayden M R; Hewitt J; Stoessl A J; Clark C; Ammann W; Martin W R
The combined use of positron emission tomography and DNA polymorphisms for preclinical detection of Huntington's disease.
Neurology 1987;37(9):1441-7.
1987: Martin W R; Hayden M R
Cerebral glucose and dopa metabolism in movement disorders.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1987;14(3 Suppl):448-51.
1986: Hayden M R; Martin W R; Stoessl A J; Clark C; Hollenberg S; Adam M J; Ammann W; Harrop R; Rogers J; Ruth T
Positron emission tomography in the early diagnosis of Huntington's disease.
Neurology 1986;36(7):888-94.
1986: Suchowersky O; Hayden M R; Martin W R; Stoessl A J; Hildebrand A M; Pate B D
Cerebral metabolism of glucose in benign hereditary chorea.
Movement disorders : official journal of the Movement Disorder Society 1986;1(1):33-44.

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