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Stephen Haydock

Research Profile

Genes & Molecular Sequences

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Gene Deletion

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Publications

TOP 3
David H Kwan; Yuhui Sun; Frank Schulz; Hui Hong; Bojana Popovic; Joalice C C Sim-Stark; Stephen F Haydock; Peter F Leadlay
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.
Barbara M Harvey; Tatiana Mironenko; Yuhui Sun; Hui Hong; Zixin Deng; Peter F Leadlay; Kira J Weissman; Stephen F Haydock
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.
Markiyan Oliynyk; Markiyan Samborskyy; John B Lester; Tatiana Mironenko; Nataliya Scott; Shilo Dickens; Stephen F Haydock; Peter F Leadlay
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.

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All Publications

2008: David H Kwan; Yuhui Sun; Frank Schulz; Hui Hong; Bojana Popovic; Joalice C C Sim-Stark; Stephen F Haydock; Peter F Leadlay
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases.
Chemistry & biology 2008;15(11):1231-40.
2007: Barbara M Harvey; Tatiana Mironenko; Yuhui Sun; Hui Hong; Zixin Deng; Peter F Leadlay; Kira J Weissman; Stephen F Haydock
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.
Chemistry & biology 2007;14(6):703-14.
2007: Markiyan Oliynyk; Markiyan Samborskyy; John B Lester; Tatiana Mironenko; Nataliya Scott; Shilo Dickens; Stephen F Haydock; Peter F Leadlay
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.
Nature biotechnology 2007;25(4):447-53.
2006: Yuhui Sun; Hui Hong; Markiyan Samborskyy; Markiyan Samboskyy; Tatiana Mironenko; Peter F Leadlay; Stephen F Haydock
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.
Microbiology (Reading, England) 2006;152(Pt 12):3507-15.
2006: Fanglu Huang; Stephen F Haydock; Dieter Spiteller; Tatiana Mironenko; Tsung-Lin Li; David O'Hagan; Peter F Leadlay; Jonathan B Spencer
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.
Chemistry & biology 2006;13(5):475-84.
2005: Stephen F Haydock; Antony appleyard; Tatiana Mironenko; John Lester; Natasha Scott; Peter F Leadlay
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
Microbiology (Reading, England) 2005;151(Pt 10):3161-9.
2005: Fanglu Huang; Stephen F Haydock; Tatiana Mironenko; Dieter Spiteller; Yanyan Li; Jonathan B Spencer
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.
Organic & biomolecular chemistry 2005;3(8):1410-8.
2004: Stephen F Haydock; Tatiana Mironenko; Haroun I Ghoorahoo; Peter F Leadlay
The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin.
Journal of biotechnology 2004;113(1-3):55-68.
2004: Timothy P Stinear; Armand Mve-Obiang; Pamela L C Small; Wafa Frigui; Melinda J Pryor; Roland Brosch; Grant A Jenkin; Paul Johnson; John K Davies; Richard E Lee; Sarojini Adusumilli; Thierry Garnier; Stephen F Haydock; Peter F Leadlay; Stewart T Cole
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1345-9.
2004: Tsung-Lin Li; Fanglu Huang; Stephen F Haydock; Tatiana Mironenko; Peter F Leadlay; Jonathan B Spencer
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.
Chemistry & biology 2004;11(1):107-19.
2000: M J Brown; Stephen F Haydock
Pathoaetiology, epidemiology and diagnosis of hypertension.
Drugs 2000;59 Suppl 2():1-12; discussion 39-40.
1998: K Salah-Bey; M Doumith; JM Michel; Stephen F Haydock; Jesús Cortés; Peter F Leadlay; MC Raynal
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea.
Molecular & general genetics : MGG 1998;257(5):542-53.