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John Hayes

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Hongyan Wang; Xiu Jun Wang; Xiaoyuan Wu; Peng Gao; Miao Geng; Yan Hai; John D Hayes; Yangxia Li; Yulong Li; Kaihua Liu; Lin Luo; Xiuwen Tang
RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2.
K Gupta; Giles E Hardingham; John D Hayes; R Patani; R A Pedersen; A Serio; D Story; T Tsujita; P Baxter; Siddharthan Chandran
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.
Larry G Higgins; John D Hayes
The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

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2013: Hongyan Wang; Xiu Jun Wang; Xiaoyuan Wu; Peng Gao; Miao Geng; Yan Hai; John D Hayes; Yangxia Li; Yulong Li; Kaihua Liu; Lin Luo; Xiuwen Tang
RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2.
Cancer research 2013;73(10):3097-108.
2012: K Gupta; Giles E Hardingham; John D Hayes; R Patani; R A Pedersen; A Serio; D Story; T Tsujita; P Baxter; Siddharthan Chandran
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.
Cell death and differentiation 2012;19(5):779-87.
2011: Larry G Higgins; John D Hayes
The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.
Chemico-biological interactions 2011;192(1-2):37-45.
2011: Larry G Higgins; John D Hayes
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Drug metabolism reviews 2011;43(2):92-137.
2011: Karen F Bell; Bashayer Al-Mubarak; Jill H Fowler; Paul S Baxter; Kunal Gupta; Tadayuki Tsujita; Sudhir Chowdhry; Rickie Patani; Siddharthan Chandran; Karen Horsburgh; John D Hayes; Giles E Hardingham
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):E1-2; author reply E3-4.
2010: John D Hayes; Michael McMahon; Sudhir Chowdhry; Albena T Dinkova-Kostova
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
Antioxidants & redox signaling 2010;13(11):1713-48.
2010: Michael McMahon; Douglas J Lamont; Kenneth A Beattie; John D Hayes
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18838-43.
2010: Jane E Weber; Aaron J Oakley; Angelika N Christ; Alan G Clark; John D Hayes; Rhonda Hall; David A Hume; Philip G Board; Mark L Smythe; Jack U Flanagan
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
European journal of medicinal chemistry 2010;45(2):447-54.
2010: A Kenneth MacLeod; Vincent P Kelly; Larry G Higgins; Michael O Kelleher; Sally A Price; Alison L Bigley; Graham R Betton; John D Hayes
Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(2):341-6.
2010: Xiu Jun Wang; John D Hayes; Larry G Higgins; C Roland Wolf; Albena T Dinkova-Kostova
Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.
Chemistry & biology 2010;17(1):75-85.
2010: Sudhir Chowdhry; Maiiada H Nazmy; Paul Meakin; Albena T Dinkova-Kostova; Shaun V Walsh; Tadayuki Tsujita; John F Dillon; Michael L J Ashford; John D Hayes
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
Free radical biology & medicine 2010;48(2):357-71.
2009: Michael O Kelleher; Michael McMahon; Ian M Eggleston; Mark J Dixon; Keiko Taguchi; Masayuki Yamamoto; John D Hayes
1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.
Carcinogenesis 2009;30(10):1754-62.
2009: John D Hayes; Albena T Dinkova-Kostova; Michael McMahon
Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):199-201.
2009: A Kenneth MacLeod; Michael McMahon; Simon M Plummer; Larry G Higgins; Trevor M Penning; Kazuhiko Igarashi; John D Hayes
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
Carcinogenesis 2009;30(9):1571-80.
2009: Larry G Higgins; Michael O Kelleher; Ian M Eggleston; Ken Itoh; Masayuki Yamamoto; John D Hayes
Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.
Toxicology and applied pharmacology 2009;237(3):267-80.
2009: John D Hayes; Michael McMahon
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
Trends in biochemical sciences 2009;34(4):176-88.
2009: Yiguo Zhang; John M Lucocq; John D Hayes
The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors.
The Biochemical journal 2009;418(2):293-310.
2009: Yiguo Zhang; Akira Kobayashi; Masayuki Yamamoto; John D Hayes
The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.
The Journal of biological chemistry 2009;284(5):3195-210.
2008: Francesc X Soriano; Frédéric Léveillé; Sofia Papadia; Larry G Higgins; James Varley; Paul Baxter; John D Hayes; Giles E Hardingham
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.
Journal of neurochemistry 2008;107(2):533-43.
2008: John D Hayes; Michael O Kelleher; Ian M Eggleston
The cancer chemopreventive actions of phytochemicals derived from glucosinolates.
European journal of nutrition 2008;47 Suppl 2():73-88.
2008: Larry G Higgins; Christophe Cavin; Ken Itoh; Masayuki Yamamoto; John D Hayes
Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.
Toxicology and applied pharmacology 2008;226(3):328-37.
2007: Xiu Jun Wang; John D Hayes; Colin Henderson; C Roland Wolf
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19589-94.
2007: Yiguo Zhang; John M Lucocq; Masayuki Yamamoto; John D Hayes
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.
The Biochemical journal 2007;408(2):161-72.
2007: Christophe Cavin; Thierry Delatour; Maricel Marin-Kuan; Daisy Holzhäuser; Larry Higgins; Claudine Bezençon; Gabriela Guignard; Sylviane Junod; Janique Richoz-Payot; Eric Gremaud; John D Hayes; Sandra Nestler; Peter G Mantle; Benoît Schilter
Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;96(1):30-9.
2006: Xiu Jun Wang; John D Hayes; C Roland Wolf
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.
Cancer research 2006;66(22):10983-94.
2006: Yiguo Zhang; Dorothy H Crouch; Masayuki Yamamoto; John D Hayes
Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
The Biochemical journal 2006;399(3):373-85.
2006: Michael McMahon; Nerys Thomas; Ken Itoh; Masayuki Yamamoto; John D Hayes
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
The Journal of biological chemistry 2006;281(34):24756-68.
2006: John D Hayes; Michael McMahon
The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.
Molecular cell 2006;21(6):732-4.
2005: Tim W P Devling; Christopher D Lindsay; Lesley I McLellan; Michael McMahon; John D Hayes
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7280-7285A.
2005: John D Hayes; Jack U Flanagan; Ian R Jowsey
Glutathione transferases.
Annual review of pharmacology and toxicology 2005;45():51-88.
2004: Gail K McWalter; Larry G Higgins; Lesley I McLellan; Colin Henderson; Lijiang Song; Paul J Thornalley; Ken Itoh; Masayuki Yamamoto; John D Hayes
Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.
The Journal of nutrition 2004;134(12 Suppl):3499S-3506S.
2004: Paul Nioi; John D Hayes
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors.
Mutation research 2004;555(1-2):149-71.
2004: Michael McMahon; Nerys Thomas; Ken Itoh; Masayuki Yamamoto; John D Hayes
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
The Journal of biological chemistry 2004;279(30):31556-67.
2004: Rachel E Thomson; Alison L Bigley; John R Foster; Ian R Jowsey; Clifford R Elcombe; Terry C Orton; John D Hayes
Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(5):653-62.
2004: Joanne Mathers; Jennifer A Fraser; Michael McMahon; Robert D C Saunders; John D Hayes; Lesley I McLellan
Antioxidant and cytoprotective responses to redox stress.
Biochemical Society symposium 2004;(71):157-76.
2003: Ian R Jowsey; Stephen A Smith; John D Hayes
Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.
Biochemical and biophysical research communications 2003;312(4):1226-35.
2003: Ian R Jowsey; Qing Jiang; Ken Itoh; Masayuki Yamamoto; John D Hayes
Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.
Molecular pharmacology 2003;64(5):1018-28.
2003: Paul Nioi; Michael McMahon; Ken Itoh; Masayuki Yamamoto; John D Hayes
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.
The Biochemical journal 2003;374(Pt 2):337-48.
2003: Ian R Jowsey; Rachel E Thomson; Terry C Orton; Clifford R Elcombe; John D Hayes
Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase.
The Biochemical journal 2003;373(Pt 2):559-69.
2003: Philip J Sherratt; Lesley I McLellan; John D Hayes
Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents.
Biochemical pharmacology 2003;66(1):51-61.
2003: Michael McMahon; Ken Itoh; Masayuki Yamamoto; John D Hayes
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
The Journal of biological chemistry 2003;278(24):21592-600.
2003: Elizabeth M Ellis; Cara M Slattery; John D Hayes
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter.
Carcinogenesis 2003;24(4):727-37.
2003: Ian R Jowsey; Paul R Murdock; Gary B T Moore; Gregory J Murphy; Stephen A Smith; John D Hayes
Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues.
Prostaglandins & other lipid mediators 2003;70(3-4):267-84.
2003: Sarah C Cobbe; Gillian C Scobie; Elizabeth Pohler; John D Hayes; Neil M Kernohan; John F Dillon
Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium.
European journal of gastroenterology & hepatology 2003;15(1):41-7.
2002: Vincent P Kelly; Philip J Sherratt; Dorothy H Crouch; John D Hayes
Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.
The Biochemical journal 2002;366(Pt 3):847-61.
2002: Simon A Chanas; Qing Jiang; Michael McMahon; Gail K McWalter; Lesley I McLellan; Clifford R Elcombe; Colin Henderson; C Roland Wolf; Graeme J Moffat; Ken Itoh; Masayuki Yamamoto; John D Hayes
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
The Biochemical journal 2002;365(Pt 2):405-16.
2002: Philip J Sherratt; Sally Williams; John Foster; Neil M Kernohan; Trevor Green; John D Hayes
Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity.
Toxicology and applied pharmacology 2002;179(2):89-97.
2001: John D Hayes; Michael McMahon
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention.
Cancer letters 2001;174(2):103-13.
2001: A Grant; L Staffas; L Mancowitz; Vincent P Kelly; Margaret M Manson; Joseph W DePierre; John D Hayes; Elizabeth M Ellis; L Mancowiz
Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility.
Biochemical pharmacology 2001;62(11):1511-9.
2001: Ian R Jowsey; AM Thomson; Jack U Flanagan; Paul R Murdock; Gary B T Moore; D J Meyer; Gregory J Murphy; Stephen A Smith; John D Hayes
Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases.
The Biochemical journal 2001;359(Pt 3):507-16.
2001: Matthew J Picklo; Sandra J Olson; John D Hayes; William R Markesbery; Thomas J Montine
Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease.
Brain research 2001;916(1-2):229-38.
2001: C Bonnesen; I M Eggleston; John D Hayes
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.
Cancer research 2001;61(16):6120-30.
2001: F Peter Guengerich; H Cai; M McMahon; John D Hayes; Thomas R Sutter; John Groopman; Zhengwu Deng; Thomas Harris
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.
Chemical research in toxicology 2001;14(6):727-37.
2001: Michael McMahon; Ken Itoh; Masayuki Yamamoto; Simon A Chanas; Colin Henderson; Lesley I McLellan; C Roland Wolf; Christophe Cavin; John D Hayes
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
Cancer research 2001;61(8):3299-307.
2000: Vincent P Kelly; LS Ireland; Elizabeth M Ellis; John D Hayes
Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues.
The Biochemical journal 2000;348 Pt 2():389-400.
2000: Vincent P Kelly; Elizabeth M Ellis; Margaret M Manson; Simon A Chanas; Graeme J Moffat; R McLeod; David J Judah; GE Neal; John D Hayes
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.
Cancer research 2000;60(4):957-69.
2000: John D Hayes; Simon A Chanas; Colin Henderson; Michael McMahon; C Sun; Graeme J Moffat; C Roland Wolf; Masayuki Yamamoto
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
Biochemical Society transactions 2000;28(2):33-41.
1999: T O'connor; LS Ireland; DJ Harrison; John D Hayes
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.
The Biochemical journal 1999;343 Pt 2():487-504.
1999: John D Hayes; Lesley I McLellan
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.
Free radical research 1999;31(4):273-300.
1999: PD McDonagh; David J Judah; John D Hayes; Lu-Yun Lian; GE Neal; C Roland Wolf; Gordon Roberts
Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.
The Biochemical journal 1999;339 ( Pt 1)():95-101.
1999: John D Hayes; Elizabeth M Ellis; GE Neal; DJ Harrison; Margaret M Manson
Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress.
Biochemical Society symposium 1999;64():141-68.
1998: Philip J Sherratt; Margaret M Manson; AM Thomson; E A Hissink; GE Neal; Peter J van Bladeren; Trevor Green; John D Hayes
Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1.
The Biochemical journal 1998;335 ( Pt 3)():619-30.
1998: AM Thomson; D J Meyer; John D Hayes
Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase.
The Biochemical journal 1998;333 ( Pt 2)():317-25.
1998: L Staffas; Elizabeth M Ellis; John D Hayes; B Lundgren; Joseph W DePierre; Louise Mankowitz
Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver.
The Biochemical journal 1998;332 ( Pt 3)():763-8.
1998: LS Ireland; DJ Harrison; GE Neal; John D Hayes
Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.
The Biochemical journal 1998;332 ( Pt 1)():21-34.
1998: John D Hayes; D J Pulford; Elizabeth M Ellis; R McLeod; R F James; J Seidegård; E Mosialou; B Jernström; GE Neal
Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1.
Chemico-biological interactions 1998;111-112():51-67.
1997: R McLeod; Elizabeth M Ellis; J R Arthur; GE Neal; David J Judah; Margaret M Manson; John D Hayes
Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin.
Cancer research 1997;57(19):4257-66.
1997: Philip J Sherratt; D J Pulford; DJ Harrison; Trevor Green; John D Hayes
Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in human.
The Biochemical journal 1997;326 ( Pt 3)():837-46.
1997: William W Johnson; YF Ueng; M Widersten; B Mannervik; John D Hayes; Philip J Sherratt; B Ketterer; F Peter Guengerich
Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters.
Biochemistry 1997;36(11):3056-60.
1996: D J Pulford; John D Hayes
Characterization of the rat glutathione S-transferase Yc2 subunit gene, GSTA5: identification of a putative antioxidant-responsive element in the 5'-flanking region of rat GSTA5 that may mediate chemoprotection against aflatoxin B1.
The Biochemical journal 1996;318 ( Pt 1)():75-84.
1996: Elizabeth M Ellis; David J Judah; GE Neal; T O'Connor; John D Hayes
Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.
Cancer research 1996;56(12):2758-66.
1996: John D Hayes; R McLeod; Elizabeth M Ellis; D J Pulford; L S Ireland; Lesley I McLellan; David J Judah; Margaret M Manson; GE Neal
Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1.
IARC scientific publications 1996;(139):175-87.
1995: Elizabeth M Ellis; John D Hayes
Substrate specificity of an aflatoxin-metabolizing aldehyde reductase.
The Biochemical journal 1995;312 ( Pt 2)():535-41.
1995: John D Hayes; R C Strange
Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress.
Free radical research 1995;22(3):193-207.
1995: John D Hayes; D J Pulford
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
Critical reviews in biochemistry and molecular biology 1995;30(6):445-600.
1994: John D Hayes; T Nguyen; David J Judah; D G Petersson; GE Neal
Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1.
The Journal of biological chemistry 1994;269(32):20707-17.
1994: Lesley I McLellan; David J Judah; GE Neal; John D Hayes
Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.
The Biochemical journal 1994;300 ( Pt 1)():117-24.
1994: David J Judah; R Davies; John D Hayes; Lesley I McLellan; GE Neal
The primary and secondary metabolism of aflatoxin B1 by rat hepatocytes cultured on matrigel.
Toxicology and applied pharmacology 1994;125(1):27-33.
1993: Elizabeth M Ellis; David J Judah; GE Neal; John D Hayes
An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10350-4.
1993: C J Wareing; Stephen Matthew Black; John D Hayes; C Roland Wolf
Increased levels of alpha-class and pi-class glutathione S-transferases in cell lines resistant to 1-chloro-2,4-dinitrobenzene.
European journal of biochemistry / FEBS 1993;217(2):671-6.
1993: John D Hayes; David J Judah; GE Neal
Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin.
Cancer research 1993;53(17):3887-94.
1992: Lesley I McLellan; David J Harrison; John D Hayes
Modulation of glutathione S-transferases and glutathione peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs.
Carcinogenesis 1992;13(12):2255-61.
1991: Peter C Hayes; L May; John D Hayes; David J Harrison
Glutathione S-transferases in human liver cancer.
Gut 1991;32(12):1546-9.
1991: John D Hayes; David J Judah; Lesley I McLellan; L A Kerr; S D Peacock; GE Neal
Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.
The Biochemical journal 1991;279 ( Pt 2)():385-98.
1991: John D Hayes; L A Kerr; S D Peacock; A D Cronshaw; Lesley I McLellan
Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix.
The Biochemical journal 1991;277 ( Pt 2)():501-12.
1991: Lesley I McLellan; L A Kerr; A D Cronshaw; John D Hayes
Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver.
The Biochemical journal 1991;276 ( Pt 2)():461-9.
1991: A J Hussey; L A Kerr; A D Cronshaw; David J Harrison; John D Hayes
Variation in the expression of Mu-class glutathione S-transferase isoenzymes from human skeletal muscle. Evidence for the existence of heterodimers.
The Biochemical journal 1991;273(Pt 2)():323-32.
1991: M Moorghen; J Cairns; Lesley Forrester; John D Hayes; A Hall; A R Cattan; C Roland Wolf; Adrian L Harris
Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa.
Carcinogenesis 1991;12(1):13-7.
1991: R J Dominey; I A Nimmo; A D Cronshaw; John D Hayes
The major glutathione S-transferase in salmonid fish livers is homologous to the mammalian pi-class GST.
Comparative biochemistry and physiology. B, Comparative biochemistry 1991;100(1):93-8.
1991: John D Hayes; David J Judah; Lesley I McLellan; GE Neal
Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1.
Pharmacology & therapeutics 1991;50(3):443-72.
1990: Lesley Forrester; John D Hayes; R Millis; D Barnes; Adrian L Harris; J J Schlager; Garth Powis; C Roland Wolf
Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue.
Carcinogenesis 1990;11(12):2163-70.
1990: John D Hayes; C R Wolf
Molecular mechanisms of drug resistance.
The Biochemical journal 1990;272(2):281-95.
1990: David J Harrison; L May; Peter C Hayes; M M Haque; John D Hayes
Glutathione S-transferases in alcoholic liver disease.
Gut 1990;31(8):909-12.
1990: John D Hayes; L A Kerr; David J Harrison; A D Cronshaw; A G Ross; GE Neal
Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Comparison of the primary structures of Ya1 and Ya2 with cloned class alpha glutathione S-transferase cDNA sequences.
The Biochemical journal 1990;268(2):295-302.
1990: Stephen Matthew Black; J D Beggs; John D Hayes; A Bartoszek; M Muramatsu; M Sakai; C Roland Wolf
Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil.
The Biochemical journal 1990;268(2):309-15.
1990: David J Harrison; L May; John D Hayes; GE Neal
Glutathione S-transferase localization in aflatoxin B1-treated rat livers.
Carcinogenesis 1990;11(6):927-31.
1990: A Forbes Howie; Lesley Forrester; M J Glancey; J J Schlager; Garth Powis; Geoffrey J Beckett; John D Hayes; C Roland Wolf
Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues.
Carcinogenesis 1990;11(3):451-8.
1990: A Forbes Howie; D Bell; P C Hayes; John D Hayes; Geoffrey J Beckett
Glutathione S-transferase isoenzymes in human bronchoalveolar lavage: a possible early marker for the detection of lung cancer.
Carcinogenesis 1990;11(2):295-300.
1989: John D Hayes; L A Kerr; A D Cronshaw
Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other Alpha class glutathione S-transferases.
The Biochemical journal 1989;264(2):437-45.
1989: Lesley I McLellan; John D Hayes
Differential induction of class alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant butylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1.
The Biochemical journal 1989;263(2):393-402.
1989: P C Hayes; C Roland Wolf; John D Hayes
Blotting techniques for the study of DNA, RNA, and proteins.
BMJ (Clinical research ed.) 1989;299(6705):965-8.
1989: John D Hayes; P K Stockman
Electrophoresis of proteins and nucleic acids: II--Techniques and applications.
BMJ (Clinical research ed.) 1989;299(6704):907-10.
1989: John D Hayes; P K Stockman
Electrophoresis of proteins and nucleic acids: I--Theory.
BMJ (Clinical research ed.) 1989;299(6703):843-6.
1989: A D Lewis; Lesley Forrester; John D Hayes; C J Wareing; J Carmichael; Adrian L Harris; M Mooghen; C Roland Wolf
Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines.
British journal of cancer 1989;60(3):327-31.
1989: David J Harrison; R Kharbanda; D Bishop; L I McLelland; John D Hayes
Glutathione S-transferase isoenzymes in human renal carcinoma demonstrated by immunohistochemistry.
Carcinogenesis 1989;10(7):1257-60.
1989: David J Harrison; R Kharbanda; D S Cunningham; Lesley I McLellan; John D Hayes
Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury.
Journal of clinical pathology 1989;42(6):624-8.
1989: Lesley I McLellan; C R Wolf; John D Hayes
Human microsomal glutathione S-transferase. Its involvement in the conjugation of hexachlorobuta-1,3-diene with glutathione.
The Biochemical journal 1989;258(1):87-93.
1989: John D Hayes; S W Milner; Simon W Walker
Expression of glyoxalase, glutathione peroxidase and glutathione S-transferase isoenzymes in different bovine tissues.
Biochimica et biophysica acta 1989;994(1):21-9.
1988: John D Hayes
Selective elution of rodent glutathione S-transferases and glyoxalase I from the S-hexyglutathione-Sepharose affinity matrix.
The Biochemical journal 1988;255(3):913-22.
1988: A D Lewis; Ian D Hickson; C N Robson; Adrian L Harris; John D Hayes; S A Griffiths; Margaret M Manson; A E Hall; J E Moss; C Roland Wolf
Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8511-5.
1988: J Carmichael; Lesley Forrester; A D Lewis; John D Hayes; P C Hayes; C Roland Wolf
Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung.
Carcinogenesis 1988;9(9):1617-21.
1987: Craig N Robson; A D Lewis; C Roland Wolf; John D Hayes; A Hall; Stephen J Proctor; Adrian L Harris; Ian D Hickson
Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.
Cancer research 1987;47(22):6022-7.
1987: John D Hayes; Lesley I McLellan; P K Stockman; J Chalmers; G J Beckett
Glutathione S-transferases in man: the relationship between rat and human enzymes.
Biochemical Society transactions 1987;15(4):721-5.
1987: Lesley I McLellan; John D Hayes
Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver.
The Biochemical journal 1987;245(2):399-406.
1987: P K Stockman; Lesley I McLellan; John D Hayes
Characterization of the basic glutathione S-transferase B1 and B2 subunits from human liver.
The Biochemical journal 1987;244(1):55-61.