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David Haynes

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Falciparum Malaria

Living Beings

Genes & Molecular Sequences

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Enzyme-Linked Immunosorbent Assay

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Publications

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Prakash Srinivasan; Jessica S Tyler; J Kathleen Moch; David Narum; Susan K Pierce; Xavier Ambroggio; Wandy L Beatty; John C Boothroyd; Ababacar Diouf; J David Haynes; Raul Herrera; Louis H Miller
Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.
Babita Mahajan; Jay A Berzofsky; Robert A Boykins; Victoria Majam; Hong Zheng; Rana Chattopadhyay; Patricia de la Vega; J Kathleen Moch; J David Haynes; Igor M Belyakov; Hira L Nakhasi; Sanjai Kumar
Multiple antigen peptide vaccines against Plasmodium falciparum malaria.
Sheetij Dutta; Lisa S Dlugosz; Joshua W Clayton; Christopher D Pool; J David Haynes; Robert A Gasser; Adrian H Batchelor
Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1.

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All Publications

2011: Prakash Srinivasan; Jessica S Tyler; J Kathleen Moch; David Narum; Susan K Pierce; Xavier Ambroggio; Wandy L Beatty; John C Boothroyd; Ababacar Diouf; J David Haynes; Raul Herrera; Louis H Miller
Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13275-80.
2010: Babita Mahajan; Jay A Berzofsky; Robert A Boykins; Victoria Majam; Hong Zheng; Rana Chattopadhyay; Patricia de la Vega; J Kathleen Moch; J David Haynes; Igor M Belyakov; Hira L Nakhasi; Sanjai Kumar
Multiple antigen peptide vaccines against Plasmodium falciparum malaria.
Infection and immunity 2010;78(11):4613-24.
2010: Sheetij Dutta; Lisa S Dlugosz; Joshua W Clayton; Christopher D Pool; J David Haynes; Robert A Gasser; Adrian H Batchelor
Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1.
Infection and immunity 2010;78(2):661-71.
2009: Sheetij Dutta; JoAnn S Sullivan; Katharine K Grady; J David Haynes; Jack Komisar; Adrian H Batchelor; Lorraine Soisson; Carter L Diggs; Donald Heppner; David Lanar; William E Collins; John W Barnwell
High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model.
PloS one 2009;4(12):e8138.
2007: Mark E Polhemus; Alan J Magill; James F Cummings; Kent Kester; Christian F Ockenhouse; David Lanar; Sheetij Dutta; Arnoldo Barbosa; Lorraine Soisson; Carter L Diggs; Sally A Robinson; J David Haynes; V Ann Stewart; Lisa A Ware; Clara Brando; Urszula Krzych; Robert A Bowden; Joe D Cohen; Marie-Claude Dubois; Opokua Ofori-Anyinam; Els De-Kock; W Ripley Ballou; Donald Heppner
Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.
Vaccine 2007;25(21):4203-12.
2007: Miranda S M Oakley; Sanjai Kumar; Vivek Anantharaman; Hong Zheng; Babita Mahajan; J David Haynes; J Kathleen Moch; Rick Fairhurst; Thomas F McCutchan; L Aravind
Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites.
Infection and immunity 2007;75(4):2012-25.
2006: Babita Mahajan; Robert Noiva; Anjali Yadava; Hong Zheng; Victoria Majam; K V K Mohan; J Kathleen Moch; J David Haynes; Hira L Nakhasi; Sanjai Kumar
Protein disulfide isomerase assisted protein folding in malaria parasites.
International journal for parasitology 2006;36(9):1037-48.
2005: Sheetij Dutta; J David Haynes; Arnoldo Barbosa; Lisa A Ware; Jeffrey D Snavely; J Kathleen Moch; Alan Thomas; David Lanar
Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum.
Infection and immunity 2005;73(4):2116-22.
2004: P V Lalitha; Lisa A Ware; Arnoldo Barbosa; Sheetij Dutta; J Kathleen Moch; J David Haynes; Bader B Fileta; Charles E White; David Lanar
Production of the subdomains of the Plasmodium falciparum apical membrane antigen 1 ectodomain and analysis of the immune response.
Infection and immunity 2004;72(8):4464-70.
2003: Sheetij Dutta; J David Haynes; J Kathleen Moch; Arnoldo Barbosa; David Lanar
Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12295-300.
2003: Karine G Le Roch; Yingyao Zhou; Peter L Blair; Munira Grainger; J Kathleen Moch; J David Haynes; Patricia de la Vega; Anthony A Holder; Serge Batalov; Daniel J Carucci; Elizabeth A Winzeler
Discovery of gene function by expression profiling of the malaria parasite life cycle.
Science (New York, N.Y.) 2003;301(5639):1503-8.
2003: Evelina Angov; Barbara M Aufiero; Ann Marie Turgeon; Michel Van Handenhove; Christian F Ockenhouse; Kent Kester; Douglas S Walsh; Jana S McBride; Marie-Claude Dubois; Joe Cohen; J David Haynes; Kenneth H Eckels; Donald Heppner; W Ripley Ballou; Carter L Diggs; Jeffrey A Lyon
Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-1(42) malaria vaccine.
Molecular and biochemical parasitology 2003;128(2):195-204.
2002: Laurence Florens; Michael Washburn; J Dale Raine; Robert M Anthony; Munira Grainger; J David Haynes; J Kathleen Moch; Nemone Muster; John B Sacci; David L Tabb; Adam A Witney; Dirk Wolters; Yimin Wu; Malcolm J Gardner; Anthony A Holder; Robert E Sinden; John R Yates; Daniel J Carucci
A proteomic view of the Plasmodium falciparum life cycle.
Nature 2002;419(6906):520-6.
2002: Sheetij Dutta; P V Lalitha; Lisa A Ware; Arnoldo Barbosa; J Kathleen Moch; Meredith A Vassell; Bader B Fileta; Svetlana Kitov; Nelly Kolodny; Donald Heppner; J David Haynes; David Lanar
Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli.
Infection and immunity 2002;70(6):3101-10.
2002: Peter L Blair; Adam A Witney; J David Haynes; J Kathleen Moch; Daniel J Carucci; John H Adams
Transcripts of developmentally regulated Plasmodium falciparum genes quantified by real-time RT-PCR.
Nucleic acids research 2002;30(10):2224-31.
2002: J David Haynes; J Kathleen Moch; Douglas S Smoot
Erythrocytic malaria growth or invasion inhibition assays with emphasis on suspension culture GIA.
Methods in molecular medicine 2002;72():535-54.
2002: J David Haynes; J Kathleen Moch
Automated synchronization of Plasmodium falciparum parasites by culture in a temperature-cycling incubator.
Methods in molecular medicine 2002;72():489-97.
2001: B Kim Lee Sim; David Narum; H Liang; Steven R Fuhrmann; Nicanor Obaldia; Robert A Gramzinski; Joao C Aguiar; J David Haynes; J Kathleen Moch; Stephen L Hoffman
Induction of biologically active antibodies in mice, rabbits, and monkeys by Plasmodium falciparum EBA-175 region II DNA vaccine.
Molecular medicine (Cambridge, Mass.) 2001;7(4):247-54.
2001: Trevor R Jones; David Narum; Alfonso S Gozalo; Joao C Aguiar; Steven R Fuhrmann; H Liang; J David Haynes; J Kathleen Moch; Carmen Lucas; Tin Luu; Alan J Magill; Stephen L Hoffman; B Kim Lee Sim
Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen.
The Journal of infectious diseases 2001;183(2):303-312.
2000: David Narum; J David Haynes; Steven R Fuhrmann; K Moch; H Liang; Stephen L Hoffman; B Kim Lee Sim
Antibodies against the Plasmodium falciparum receptor binding domain of EBA-175 block invasion pathways that do not involve sialic acids.
Infection and immunity 2000;68(4):1964-6.
1998: Alfonso S Gozalo; Carmen Lucas; MI Cachay; Bruce T Wellde; T Hall; B Bell; J Wood; D Watts; MT Wooster; Jeffrey A Lyon; J Kathleen Moch; J David Haynes; J S Williams; Carolyn Holland; E Watson; Kent Kester; David C Kaslow; W Ripley Ballou
Passive transfer of growth-inhibitory antibodies raised against yeast-expressed recombinant Plasmodium falciparum merozoite surface protein-1(19).
The American journal of tropical medicine and hygiene 1998;59(6):991-7.