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Stanley Hazen

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Bruce Levison; Zeneng Wang; Renliang Zhang; Joseph A DiDonato; Xiaoming Fu; Stanley L Hazen
Quantification of fatty acid oxidation products using online high-performance liquid chromatography tandem mass spectrometry.
Robert A Koeth; Ronald M Krauss; Bruce Levison; James D Lewis; Hongzhe Li; Lin Li; Aldons J Lusis; Elin Org; Brendan T Sheehy; Jonathan D Smith; W H Wilson Tang; Zeneng Wang; Manya Warrier; Gary D Wu; Yuping Wu; Earl B Britt; J Mark Brown; Jennifer A Buffa; Frederic D Bushman; Jun Chen; Joseph A DiDonato; Xiaoming Fu; Stanley L Hazen
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis.
Gang Zhou; W H Wilson Tang; Hooman Allayee; Jaana Hartiala; Stanley L Hazen; Gopal K Marathe; Thomas M McIntyre
Aspirin Hydrolysis in Plasma Is a Variable Function of Butyrylcholinesterase and Platelet-activating Factor Acetylhydrolase 1b2 (PAFAH1b2).

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2013: Bruce Levison; Zeneng Wang; Renliang Zhang; Joseph A DiDonato; Xiaoming Fu; Stanley L Hazen
Quantification of fatty acid oxidation products using online high-performance liquid chromatography tandem mass spectrometry.
Free radical biology & medicine 2013;59():2-13.
2013: Robert A Koeth; Ronald M Krauss; Bruce Levison; James D Lewis; Hongzhe Li; Lin Li; Aldons J Lusis; Elin Org; Brendan T Sheehy; Jonathan D Smith; W H Wilson Tang; Zeneng Wang; Manya Warrier; Gary D Wu; Yuping Wu; Earl B Britt; J Mark Brown; Jennifer A Buffa; Frederic D Bushman; Jun Chen; Joseph A DiDonato; Xiaoming Fu; Stanley L Hazen
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis.
Nature medicine 2013;19(5):576-85.
2013: Gang Zhou; W H Wilson Tang; Hooman Allayee; Jaana Hartiala; Stanley L Hazen; Gopal K Marathe; Thomas M McIntyre
Aspirin Hydrolysis in Plasma Is a Variable Function of Butyrylcholinesterase and Platelet-activating Factor Acetylhydrolase 1b2 (PAFAH1b2).
The Journal of biological chemistry 2013;288(17):11940-8.
2013: W H Wilson Tang; Zeneng Wang; Yuping Wu; Earl B Britt; Xiaoming Fu; Robert A Koeth; Bruce S Levison; Stanley L Hazen
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
The New England journal of medicine 2013;368(17):1575-84.
2013: W H Wilson Tang; Richard W Troughton; Zeneng Wang; Allen Borowski; Allan L Klein; Kevin Shrestha; Stanley L Hazen
Protein carbamylation in chronic systolic heart failure: relationship with renal impairment and adverse long-term outcomes.
Journal of cardiac failure 2013;19(4):219-24.
2013: David J Kennedy; Shirley Mann; Michael Pepoy; W H Wilson Tang; Yuping Wu; Yiying Fan; Stanley L Hazen
Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease.
Journal of the American Heart Association 2013;2(2):e000104.
2013: Robert A Koeth; W H Wilson Tang; Zeneng Wang; Xiaoming Fu; Kamyar Kalantar-Zadeh; Stanley L Hazen
Protein carbamylation predicts mortality in ESRD.
Journal of the American Society of Nephrology : JASN 2013;24(5):853-61.
2013: Valentin Gogonea; Philip Callow; Joseph A DiDonato; Gary S Gerstenecker; Xavier Lee; Hélène Malet; Vitaliy Pipich; Guy Schoehn; Jonathan D Smith; Thomas C Tallant; Celalettin Topbas; Matthew A Wagner; Zhiping Wu; Stanley L Hazen
The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.
Journal of lipid research 2013;54(4):966-83.
2013: W H Wilson Tang; Yuping Wu; Naveed Iqbal; Stanley L Hazen
Usefulness of cardiac biomarker score for risk stratification in stable patients undergoing elective cardiac evaluation across glycemic status.
The American journal of cardiology 2013;111(4):465-70.
2013: W H Wilson Tang; Richard W Troughton; Zeneng Wang; Allan L Klein; Kevin Shrestha; Stanley L Hazen
Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure.
Journal of cardiac failure 2013;19(2):87-93.
2013: Bakytzhan Bakhautdin; Erin Patricia Childers; Carol de la Motte; Maria Febbraio; Esen Goksoy; Muhammet Fatih Gulen; Stanley L Hazen; Xiaoxia Li; Paul L Fox
Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease.
Gut 2013;62(2):209-19.
2013: Brian J Bennett; Rosanne Crooke; Peter A Edwards; Mark Graham; Jill Gregory; Stanley L Hazen; Richard Lee; Yonghong Meng; Diana M Shih; Zeneng Wang; Thomas Q de Aguiar Vallim; Hooman Allayee; Aldons J Lusis
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Cell metabolism 2013;17(1):49-60.
2012: Edward A Fisher; Stanley L Hazen; Bernd Hewing; Jonathan E Feig; Jonathan D Smith
High-density lipoprotein function, dysfunction, and reverse cholesterol transport.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(12):2813-20.
2012: Leonor Thomson; Epida Tsika; Yuping Wu; Paschalis-Thomas Doulias; Todd M Greco; Stanley L Hazen; Richard Lightfoot; Marissa Martinez; Ioannis Parastatidis; W H Wilson Tang; Margarita Tenopoulou; Harry Ischiropoulos
Immunoglobulins against tyrosine-nitrated epitopes in coronary artery disease.
Circulation 2012;126(20):2392-401.
2012: W H Wilson Tang; Yuping Wu; Hooman Allayee; Jeanette Erdmann; Yiying Fan; Jaana Hartiala; Sekar Kathiresan; Ruth McPherson; Robert Roberts; Alexandre Stewart; Stanley L Hazen
Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(11):2803-12.
2012: Jia Qiu; Kamini Singh; Samjhana Thapalaya; Cynthia Tsien; Conrad Chris Weihl; George Dubyak; Bijan Eghtesad; Xiaoming Fu; Stanley L Hazen; Christine McDonald; Sathyamangla V Naga Prasad; Arvind Narayanan; alex almasan; James K Ching; Srinivasan Dasarathy
Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis.
American journal of physiology. Endocrinology and metabolism 2012;303(8):E983-93.
2012: Claudia O Zein; Xiaoming Fu; Stanley L Hazen; John P Kirwan; Rocio Lopez; Arthur J McCullough; Lisa M Yerian; Ariel E Feldstein
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism.
Hepatology (Baltimore, Md.) 2012;56(4):1291-9.
2012: Stanley L Hazen; Jonathan D Smith
An antiatherosclerotic signaling cascade involving intestinal microbiota, microRNA-10b, and ABCA1/ABCG1-mediated reverse cholesterol transport.
Circulation research 2012;111(8):948-50.
2012: Matthias Dupont; Stanley L Hazen; Yuping Wu; W H Wilson Tang
Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events.
Circulation. Heart failure 2012;5(5):602-9.
2012: Stanley L Hazen
New lipid and lipoprotein targets for the treatment of cardiometabolic diseases.
Journal of lipid research 2012;53(9):1719-21.
2012: Jie Jia; Jonathan D Smith; Dennis J Stuehr; Belinda Willard; Abul Arif; Stanley L Hazen; Paul L Fox
Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation.
Molecular cell 2012;47(4):656-63.
2012: Rajan S Patel; Hooman Allayee; Jaana Hartiala; Stanley L Hazen; Ying X Liu; Ronak Patel; S Tanveer Rab; Ayaz Rahman; Habib Samady; Salman Sher; Shaoyong Su; Yan V Sun; W H Wilson Tang; Viola Vaccarino; Emir Veledar; A Maziar Zafari; Arshed A Quyyumi
Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography.
Circulation. Cardiovascular genetics 2012;5(4):441-9.
2012: Zhili Shao; Kevin Shrestha; Wendy Sweet; Allen Borowski; Stanley L Hazen; Christine S Moravec; Akanksha Thakur; James D Thomas; Zeneng Wang; W H Wilson Tang
Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1.
Journal of the American College of Cardiology 2012;59(13):1150-8.
2012: W H Wilson Tang; Yuping Wu; Ruth McPherson; Robert Roberts; Alexandre Stewart; Hooman Allayee; Yiying Fan; Paul L Fox; Jaana Hartiala; Stanley L Hazen
Clinical and genetic association of serum ceruloplasmin with cardiovascular risk.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):516-22.
2011: Jaana Hartiala; Dalin Li; David V Conti; Susanna Vikman; Yesha Patel; W H Wilson Tang; Marie-Louise Brennan; John William Newman; Charles B Stephensen; Patrice Armstrong; Stanley L Hazen; Hooman Allayee
Genetic contribution of the leukotriene pathway to coronary artery disease.
Human genetics 2011;129(6):617-27.
2011: Zhiping Wu; Valentin Gogonea; Xavier Lee; Roland P May; Vitaliy Pipich; Matthew A Wagner; Arundhati Undurti; Thomas C Tallant; Camelia Baleanu-Gogonea; Francesca Charlton; Alexander Ioffe; Joseph A DiDonato; Kerry-Anne Rye; Stanley L Hazen
The low resolution structure of ApoA1 in spherical high density lipoprotein revealed by small angle neutron scattering.
The Journal of biological chemistry 2011;286(14):12495-508.
2011: Zeneng Wang; Elizabeth Klipfell; Brian J Bennett; Robert Koeth; Bruce Levison; Brandon Dugar; Ariel E Feldstein; Earl B Britt; Xiaoming Fu; Yoon-Mi Chung; Yuping Wu; Phil Schauer; Jonathan D Smith; Hooman Allayee; W H Wilson Tang; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Nature 2011;472(7341):57-63.
2011: Richard C Becker; Kenneth W Mahaffey; Hongqiu Yang; A J Marian; Mark I Furman; A Michael Lincoff; Stanley L Hazen; John L Petersen; Craig J Reist; Neal S Kleiman
Heparin-associated anti-Xa activity and platelet-derived prothrombotic and proinflammatory biomarkers in moderate to high-risk patients with acute coronary syndrome.
Journal of thrombosis and thrombolysis 2011;31(2):146-53.
2011: Suzy A A Comhair; Douglas Curran-Everett; Raed A Dweik; Serpil C Erzurum; Benjamin Gaston; Jeffrey Hammel; Stanley L Hazen; Elliot Israel; W Nizar Jarjour; Deborah Meyers; Wendy Moore; Stephen P Peters; Kristin S Ricci; W Gerald Teague; Sally Wenzel; Elizabeth J Ampleford; Eugene R Bleecker; William W Busse; William J Calhoun; Mario Castro; Kian Fan Chung
Detrimental effects of environmental tobacco smoke in relation to asthma severity.
PloS one 2011;6(5):e18574.
2011: W H Wilson Tang; Yuping Wu; Shirley Mann; Michael Pepoy; Kevin Shrestha; Allen Borowski; Stanley L Hazen
Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure.
Circulation. Heart failure 2011;4(1):59-64.
2011: W H Wilson Tang; Yuping Wu; Stephen J Nicholls; Stanley L Hazen
Plasma myeloperoxidase predicts incident cardiovascular risks in stable patients undergoing medical management for coronary artery disease.
Clinical chemistry 2011;57(1):33-9.
2010: Thomas M McIntyre; Stanley L Hazen
Lipid oxidation and cardiovascular disease: introduction to a review series.
Circulation research 2010;107(10):1167-9.
2010: Stanley L Hazen
Neutrophils, hypercholesterolemia, and atherogenesis.
Circulation 2010;122(18):1786-8.
2010: Peggy Robinet; Zeneng Wang; Stanley L Hazen; Jonathan D Smith
A simple and sensitive enzymatic method for cholesterol quantification in macrophages and foam cells.
Journal of lipid research 2010;51(11):3364-9.
2010: Ariel E Feldstein; Rocio Lopez; Tarek Abu-Rajab Tamimi; Lisa Yerian; Yoon-Mi Chung; Michael Berk; Renliang Zhang; Thomas M McIntyre; Stanley L Hazen
Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Journal of lipid research 2010;51(10):3046-54.
2010: Stephen J Nicholls; W H Wilson Tang; Heather Scoffone; Danielle M Brennan; Jaana Hartiala; Hooman Allayee; Stanley L Hazen
Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy.
Journal of lipid research 2010;51(10):3055-61.
2010: Valentin Gogonea; Zhiping Wu; Xavier Lee; Vitaliy Pipich; Xin-Min Li; Alexander I Ioffe; Joseph A Didonato; Stanley L Hazen
Congruency between biophysical data from multiple platforms and molecular dynamics simulation of the double-super helix model of nascent high-density lipoprotein.
Biochemistry 2010;49(34):7323-43.
2010: Marie-Luise Brennan; Anupama Reddy; W H Wilson Tang; Yuping Wu; Danielle M Brennan; Amy Hsu; Shirley A Mann; Peter L Hammer; Stanley L Hazen
Comprehensive peroxidase-based hematologic profiling for the prediction of 1-year myocardial infarction and death.
Circulation 2010;122(1):70-9.
2010: W H Wilson Tang; Yuping Wu; Stephen J Nicholls; Danielle M Brennan; Michael Pepoy; Shirley Mann; Alan Pratt; Frederick Van Lente; Stanley L Hazen
Subclinical myocardial necrosis and cardiovascular risk in stable patients undergoing elective cardiac evaluation.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):634-40.
2009: Zhiping Wu; Valentin Gogonea; Xavier Lee; Matthew A Wagner; Xin-Min Li; Ying Huang; Arundhati Undurti; Roland P May; Michael Haertlein; Martine Moulin; Irina Gutsche; Giuseppe Zaccai; Joseph A DiDonato; Stanley L Hazen
Double superhelix model of high density lipoprotein.
The Journal of biological chemistry 2009;284(52):36605-19.
2009: Arundhati Undurti; Ying Huang; Joseph A Lupica; Jonathan D Smith; Joseph A DiDonato; Stanley L Hazen
Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle.
The Journal of biological chemistry 2009;284(45):30825-35.
2009: Zeneng Wang; W H Wilson Tang; Leslie Cho; Danielle M Brennan; Stanley L Hazen
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1383-91.
2009: Sangeeta R Kashyap; Dima L Diab; Allison R Baker; Lisa Yerian; Harpreet Bajaj; Courtney Gray-McGuire; Philip R Schauer; Manjula Gupta; Ariel E Feldstein; Stanley L Hazen; Catherine M Stein
Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort.
Obesity (Silver Spring, Md.) 2009;17(9):1696-701.
2009: W H Wilson Tang; Zeneng Wang; Leslie Cho; Danielle M Brennan; Stanley L Hazen
Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk.
Journal of the American College of Cardiology 2009;53(22):2061-7.
2009: W H Wilson Tang; Ronit Katz; Marie-Luise Brennan; Ronnier J Aviles; Russell P Tracy; Bruce M Psaty; Stanley L Hazen
Usefulness of myeloperoxidase levels in healthy elderly subjects to predict risk of developing heart failure.
The American journal of cardiology 2009;103(9):1269-74.
2009: Xiaobo Zhou; Honghui Wang; Jun Wang; Yuan Wang; Gerard Hoehn; Joseph Azok; Marie-Luise Brennan; Stanley L Hazen; King Li; Shih-Fu Chang; Stephen Wong
Identification of biomarkers for risk stratification of cardiovascular events using genetic algorithm with recursive local floating search.
Proteomics 2009;9(8):2286-94.
2009: Stephen J Nicholls; Stanley L Hazen
Myeloperoxidase, modified lipoproteins, and atherogenesis.
Journal of lipid research 2009;50 Suppl():S346-51.
2009: Mehdi H Shishehbor; Stanley L Hazen
Jupiter to earth: a statin helps people with normal LDL-C and high hs-CRP, but what does it mean?
Cleveland Clinic journal of medicine 2009;76(1):37-44.
2008: Dima L Diab; Lisa Yerian; Philip Schauer; Sangeeta R Kashyap; Rocio Lopez; Stanley L Hazen; Ariel E Feldstein
Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(11):1249-54.
2008: Dao-Quan Peng; Gregory Brubaker; Zhiping Wu; Lemin Zheng; Belinda Willard; Michael Kinter; Stanley L Hazen; Jonathan D. Smith
Apolipoprotein A-I tryptophan substitution leads to resistance to myeloperoxidase-mediated loss of function.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(11):2063-70.
2008: Wai Hong Wilson Tang; Wilson Tong; Kevin Shrestha; Zeneng Wang; Bruce S Levison; Brian Delfraino; Bo Hu; Richard W Troughton; Allan L Klein; Stanley L Hazen
Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure.
European heart journal 2008;29(20):2506-13.
2008: Abigail Lara; Sumita B Khatri; Zeneng Wang; Suzy A A Comhair; Weiling Xu; raed dweik; Melanie Bodine; Bruce S Levison; Jeffrey Hammel; Eugene R Bleecker; William Busse; William J Calhoun; Mario Castro; Kian Fan Chung; Douglas Curran-Everett; Benjamin Gaston; Elliot Israel; Nizar Jarjour; Wendy Moore; Stephen P Peters; W Gerald Teague; Sally E Wenzel; Stanley L Hazen; Serpil C Erzurum
Alterations of the arginine metabolome in asthma.
American journal of respiratory and critical care medicine 2008;178(7):673-81.
2008: Viola Vaccarino; Marie-Luise Brennan; Andrew H Miller; J Douglas Bremner; James C Ritchie; Frauke Lindau; Emir Veledar; Shaoyong Su; Nancy V Murrah; Linda Jones; Farhan Jawed; Jun Dai; Jack Goldberg; Stanley L Hazen
Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study.
Biological psychiatry 2008;64(6):476-83.
2008: Tuan D Pham; Honghui Wang; Xiaobo Zhou; Dominik Beck; Miriam Brandl; Gerard Hoehn; Joseph Azok; Marie-Luise Brennan; Stanley L Hazen; King Li; Stephen Wong
Computational prediction models for early detection of risk of cardiovascular events using mass spectrometry data.
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society 2008;12(5):636-43.
2008: Guangxu Jin; Xiaobo Zhou; Honghui Wang; Hong Zhao; Kemi Cui; Xiang-Sun Zhang; Luonan Chen; Stanley L Hazen; King Li; Stephen Wong
The knowledge-integrated network biomarkers discovery for major adverse cardiac events.
Journal of proteome research 2008;7(9):4013-21.
2008: Viktor Brovkovych; Xiao-Pei Gao; Evan Ong; Svitlana Brovkovych; Marie-Luise Brennan; Xiao Su; Stanley L Hazen; Asrar B Malik; Randal A Skidgel
Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.
American journal of physiology. Lung cellular and molecular physiology 2008;295(1):L96-103.
2008: Ephraim Sehayek; Stanley L Hazen
Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1296-7.
2008: Mehdi H Shishehbor; Leonardo P J Oliveira; Michael Lauer; Dennis L Sprecher; Kathy Wolski; Leslie Cho; Byron J Hoogwerf; Stanley L Hazen
Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney disease.
The American journal of cardiology 2008;101(12):1741-6.
2008: Stanley L Hazen
Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity.
The Journal of biological chemistry 2008;283(23):15527-31.
2008: Dalia El-Bejjani; Stanley L Hazen; Wilma Mackay; Nina E Glass; Todd Hulgan; Marisa Tungsiripat; Grace A McComsey
Higher plasma myeloperoxidase levels are not associated with an increased risk for cardiovascular events in HIV-infected adults.
HIV clinical trials 2008;9(3):207-11.
2008: Leslie Cho; Byron J Hoogwerf; Julie Huang; Danielle M Brennan; Stanley L Hazen
Gender differences in utilization of effective cardiovascular secondary prevention: a Cleveland clinic prevention database study.
Journal of women's health (2002) 2008;17(4):515-21.
2008: David A Morrow; Marc S Sabatine; Marie-Luise Brennan; James A de Lemos; Sabina A Murphy; Christian T Ruff; Nader Rifai; Christopher P Cannon; Stanley L Hazen
Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18.
European heart journal 2008;29(9):1096-102.
2008: Xi Chen; Wujuan Zhang; James Laird; Stanley L Hazen; Robert G Salomon
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids.
Journal of lipid research 2008;49(4):832-46.
2008: Tamali Bhattacharyya; Stephen J Nicholls; Eric J Topol; Renliang Zhang; Xia Yang; David Schmitt; Xiaoming Fu; Mingyuan Shao; Danielle M Brennan; Stephen G Ellis; Marie-Luise Brennan; Hooman Allayee; Aldons J Lusis; Stanley L Hazen
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.
JAMA : the journal of the American Medical Association 2008;299(11):1265-76.
2008: Jean-Claude Tardif; Jean Grégoire; Philippe L L'Allier; Reda Ibrahim; Todd J Anderson; François Reeves; Lawrence M Title; Erick Schampaert; Michel LeMay; Jacques Lespérance; Rob Scott; Marie-Claude Guertin; Marie-Luise Brennan; Stanley L Hazen; Olivier Bertrand
Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial.
Atherosclerosis 2008;197(1):480-6.
2008: Adriana G Ioachimescu; Danielle M Brennan; Brian M Hoar; Stanley L Hazen; Byron J Hoogwerf
Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study.
Arthritis and rheumatism 2008;58(2):623-30.
2008: Michael E Greenberg; Xin-Min Li; Bogdan G Gugiu; Xiaodong Gu; Jun Qin; Robert G Salomon; Stanley L Hazen
The lipid whisker model of the structure of oxidized cell membranes.
The Journal of biological chemistry 2008;283(4):2385-96.
2008: Gong-Qing Shen; Shaoqi Rao; Nicola Martinelli; Lin Li; Oliviero Olivieri; Roberto Corrocher; Kalil Abdullah; Stanley L Hazen; Jonathan D. Smith; John Barnard; Edward F Plow; Domenico Girelli; Qing K Wang
Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population.
Journal of human genetics 2008;53(2):144-50.
2007: Steven B Cannady; Pete S Batra; Rachel Leahy; Martin J Citardi; Allison J Janocha; Kristin Ricci; Suzy A A Comhair; Melanie Bodine; Zeneng Wang; Stanley L Hazen; Serpil C Erzurum
Signal transduction and oxidative processes in sinonasal polyposis.
The Journal of allergy and clinical immunology 2007;120(6):1346-53.
2007: Stephen J Nicholls; Zeneng Wang; Robert Koeth; Bruce Levison; Brian DelFraino; Vladimir Dzavik; Owen W Griffith; David Hathaway; Julio A Panza; Steven E Nissen; Judith S Hochman; Stanley L Hazen
Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction.
Circulation 2007;116(20):2315-24.
2007: Gong-Qing Shen; Lin Li; Domenico Girelli; Sara Seidelmann; Shaoqi Rao; Chun Fan; Jeong Euy Park; Quansheng Xi; Jing Li; Ying Hu; Oliviero Olivieri; Kandice Marchant; John Barnard; Roberto Corrocher; Robert Elston; June Cassano; Susan Henderson; Stanley L Hazen; Edward F Plow; Eric J Topol; Qing K Wang
An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.
American journal of human genetics 2007;81(4):780-91.
2007: Zeneng Wang; Stephen J Nicholls; E Rene Rodriguez; Outi Kummu; Sohvi Hörkkö; John Barnard; Wanda F Reynolds; Eric J Topol; Joseph A DiDonato; Stanley L Hazen
Protein carbamylation links inflammation, smoking, uremia and atherogenesis.
Nature medicine 2007;13(10):1176-84.
2007: Jenny C Lee; Daphna Weissglas-Volkov; Mira Kyttälä; Janet S Sinsheimer; Anne Jokiaho; Tjerk W A de Bruin; Aldons J Lusis; Marie-Luise Brennan; Marleen M J van Greevenbroek; Carla J H van der Kallen; Stanley L Hazen; Päivi Pajukanta
USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2222-7.
2007: Eugene A Podrez; Tatiana V Byzova; Maria Febbraio; Robert G Salomon; Yi Ma; Manojkumar Valiyaveettil; Eugenia Poliakov; Mingjiang Sun; Paula J Finton; Brian Curtis; Juhua Chen; Renliang Zhang; Roy L Silverstein; Stanley L Hazen
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.
Nature medicine 2007;13(9):1086-95.
2007: Zhiping Wu; Matthew A Wagner; Lemin Zheng; John S Parks; Jacinto M Shy; Jonathan D. Smith; Valentin Gogonea; Stanley L Hazen
The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction.
Nature structural & molecular biology 2007;14(9):861-8.
2007: Ioannis Parastatidis; Leonor Thomson; Diana M Fries; Ryan E Moore; Junichiro Tohyama; Xiaoming Fu; Stanley L Hazen; Harry F G Heijnen; Michelle K Dennehy; Daniel C Liebler; Daniel J Rader; Harry Ischiropoulos
Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.
Circulation research 2007;101(4):368-76.
2007: Marijn C Meuwese; Erik S G Stroes; Stanley L Hazen; Joram N I van Miert; Jan Albert Kuivenhoven; Robert G Schaub; Nicholas J Wareham; Robert Luben; John J P Kastelein; Kay-Tee Khaw; S Matthijs Boekholdt
Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study.
Journal of the American College of Cardiology 2007;50(2):159-65.
2007: Deepak L Bhatt; Derek P Chew; Cindy L Grines; Debabrata Mukherjee; Massoud A Leesar; Ian C Gilchrist; John C Corbelli; James C Blankenship; Avichai Eres; Steven R Steinhubl; Walter Tan; Jon R Resar; Amjad Almahameed; Ahmed Abdel-Latif; W H Wilson Tang; H Wilson Tang; Danielle Brennan; Ellen McErlean; Stanley L Hazen; Eric J Topol
Peroxisome proliferator-activated receptor gamma agonists for the Prevention of Adverse events following percutaneous coronary Revascularization--results of the PPAR study.
American heart journal 2007;154(1):137-43.
2007: W H Wilson Tang; Wilson Tong; Richard W Troughton; Maureen G Martin; Kevin Shrestha; Allen Borowski; Susan E Jasper; Stanley L Hazen; Allan L Klein
Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure.
Journal of the American College of Cardiology 2007;49(24):2364-70.
2007: Grace A McComsey; Maryann O'Riordan; Stanley L Hazen; Dalia El-Bejjani; Shweta Bhatt; Marie-Luise Brennan; Norma Storer; Jerome Adell; Dean A Nakamoto; Vikram S Dogra
Increased carotid intima media thickness and cardiac biomarkers in HIV infected children.
AIDS (London, England) 2007;21(8):921-7.
2007: Vladimir Dzavík; Gad Cotter; Harmony R Reynolds; John H Alexander; Krishnan Ramanathan; Amanda L Stebbins; David Hathaway; Michael E Farkouh; Erik Ohman; David A Baran; Roland Prondzinsky; Julio A Panza; Warren J Cantor; Zvi Vered; Christopher E Buller; Neal S Kleiman; John G Webb; David R Holmes; Joseph E Parrillo; Stanley L Hazen; Steven S Gross; Robert A Harrington; Judith S Hochman
Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.
European heart journal 2007;28(9):1109-16.
2007: Xin-Min Li; Robert G Salomon; Jun Qin; Stanley L Hazen
Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36.
Biochemistry 2007;46(17):5009-17.
2007: Stephen J Nicholls; Kathy Wolski; Ilke Sipahi; Paul Schoenhagen; Tim Crowe; Samir R Kapadia; Stanley L Hazen; E Murat Tuzcu; Steven E Nissen
Rate of progression of coronary atherosclerotic plaque in women.
Journal of the American College of Cardiology 2007;49(14):1546-51.
2007: Stephen J Nicholls; E Murat Tuzcu; Amy Hsu; Kathy Wolski; Ilke Sipahi; Paul Schoenhagen; Tim Crowe; Samir R Kapadia; Stanley L Hazen; Steven E Nissen
Comparison of coronary atherosclerotic volume in patients with glomerular filtration rates < or = 60 versus > 60 ml/min/1.73 m(2): a meta-analysis of intravascular ultrasound studies.
The American journal of cardiology 2007;99(6):813-6.
2007: Tzung K Hsiai; Juliana Hwang; Mark L Barr; Adria Correa; Ryan Hamilton; Mohammad Alavi; Mahsa Rouhanizadeh; Enrique Cadenas; Stanley L Hazen
Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration.
Free radical biology & medicine 2007;42(4):519-29.
2007: Stephen J Nicholls; E Murat Tuzcu; Ilke Sipahi; Adam W Grasso; Paul Schoenhagen; Tingfei Hu; Kathy Wolski; Tim Crowe; Milind Y Desai; Stanley L Hazen; Samir R Kapadia; Steven E Nissen
Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis.
JAMA : the journal of the American Medical Association 2007;297(5):499-508.
2007: Leonor Thomson; Jason Christie; Caryn Vadseth; Paul N Lanken; Xiaoming Fu; Stanley L Hazen; Harry Ischiropoulos
Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with acute lung injury after major trauma.
American journal of respiratory cell and molecular biology 2007;36(2):152-7.
2007: Stephen J Nicholls; E Murat Tuzcu; Kathy Wolski; Ilke Sipahi; Paul Schoenhagen; Tim Crowe; Samir R Kapadia; Stanley L Hazen; Steven E Nissen
Coronary artery calcification and changes in atheroma burden in response to established medical therapies.
Journal of the American College of Cardiology 2007;49(2):263-70.
2007: Shany Blum; Roy Asaf; Julia Guetta; Rachel Miller-Lotan; Rabea Asleh; Ran Kremer; Nina S Levy; Franklin G Berger; Doron Aronson; Xiaoming Fu; Renliang Zhang; Stanley L Hazen; Andrew P Levy
Haptoglobin genotype determines myocardial infarct size in diabetic mice.
Journal of the American College of Cardiology 2007;49(1):82-7.
2006: Mehdi H Shishehbor; Renliang Zhang; Hector Medina; Marie-Luise Brennan; Danielle M Brennan; Stephen G Ellis; Eric J Topol; Stanley L Hazen
Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease.
Free radical biology & medicine 2006;41(11):1678-83.
2006: Michael E Greenberg; Mingjiang Sun; Renliang Zhang; Maria Febbraio; Roy L Silverstein; Stanley L Hazen
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells.
The Journal of experimental medicine 2006;203(12):2613-25.
2006: Shengqiang Gao; Renliang Zhang; Michael E Greenberg; Mingjiang Sun; Xi Chen; Bruce Levison; Robert G Salomon; Stanley L Hazen
Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo.
The Journal of biological chemistry 2006;281(42):31298-308.
2006: W H Wilson Tang; Marie-Luise Brennan; Kiran Philip; Wilson Tong; Shirley Mann; Frederick Van Lente; Stanley L Hazen
Plasma myeloperoxidase levels in patients with chronic heart failure.
The American journal of cardiology 2006;98(6):796-9.
2006: S Ohidar Rahaman; David J Lennon; Maria Febbraio; Eugene A Podrez; Stanley L Hazen; Roy L Silverstein
A CD36-dependent signaling cascade is necessary for macrophage foam cell formation.
Cell metabolism 2006;4(3):211-21.
2006: Kamyar Kalantar-Zadeh; Marie-Luise Brennan; Stanley L Hazen
Serum myeloperoxidase and mortality in maintenance hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2006;48(1):59-68.
2006: Béatrice Blanchard-Fillion; Delphine Prou; Manuela Polydoro; David Spielberg; Elpida Tsika; Zeneng Wang; Stanley L Hazen; Michael Koval; Serge Przedborski; Harry Ischiropoulos
Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(23):6124-30.
2006: Samuel F Lockwood; Marc S Penn; Stanley L Hazen; Zsolt Bikádi; Ferenc Zsila
The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo.
Life sciences 2006;79(2):162-74.
2006: Stephen J Nicholls; E Murat Tuzcu; Ilke Sipahi; Paul Schoenhagen; Stanley L Hazen; Fady Ntanios; Chuan-Chuan Wun; Steven E Nissen
Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study).
The American journal of cardiology 2006;97(11):1553-7.
2006: Stephen J Nicholls; E Murat Tuzcu; Tim Crowe; Ilke Sipahi; Paul Schoenhagen; Samir Kapadia; Stanley L Hazen; Chuan-Chuan Wun; Michele Norton; Fady Ntanios; Steven E Nissen
Relationship between cardiovascular risk factors and atherosclerotic disease burden measured by intravascular ultrasound.
Journal of the American College of Cardiology 2006;47(10):1967-75.
2006: Martin J Citardi; Wei Song; Pete S Batra; Donald C Lanza; Stanley L Hazen
Characterization of oxidative pathways in chronic rhinosinusitis and sinonasal polyposis.
American journal of rhinology 2006;20(3):353-9.
2006: Sudakshina Ghosh; Allison J Janocha; Mark A Aronica; Shadi Swaidani; Suzy A A Comhair; Weiling Xu; Lemin Zheng; Suma Kaveti; Michael Kinter; Stanley L Hazen; Serpil C Erzurum
Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5587-97.
2006: Mingjiang Sun; Silvia C Finnemann; Maria Febbraio; Lian Shan; Suresh Annangudi; Eugene A Podrez; George Hoppe; Ruth M Darrow; Daniel T Organisciak; Robert G Salomon; Roy L Silverstein; Stanley L Hazen
Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.
The Journal of biological chemistry 2006;281(7):4222-30.
2006: Eitan Gross; Dao-Quan Peng; Stanley L Hazen; Jonathan D. Smith
A novel folding intermediate state for apolipoprotein A-I: role of the amino and carboxy termini.
Biophysical journal 2006;90(4):1362-70.
2006: Garrett J Gross; Stanley L Hazen; Samuel F Lockwood
Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats.
Molecular and cellular biochemistry 2006;283(1-2):23-30.
2006: Semira Galijasevic; Ghassan M Saed; Stanley L Hazen; Husam M Abu-Soud
Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.
Biochemistry 2006;45(4):1255-62.
2005: David A Munson; Peter H Grubb; Jay D Kerecman; Donald C McCurnin; Bradley A Yoder; Stanley L Hazen; Philip W Shaul; Harry Ischiropoulos
Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease.
American journal of respiratory cell and molecular biology 2005;33(6):582-8.
2005: Nikolay V Vasilyev; Timothy Williams; Marie-Luise Brennan; Samuel Unzek; Xiaorong Zhou; Jay W Heinecke; Douglas R Spitz; Eric J Topol; Stanley L Hazen; Marc S Penn
Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction.
Circulation 2005;112(18):2812-20.
2005: Astrid Haegens; Albert van der Vliet; Kelly J Butnor; Nicholas H Heintz; Douglas J Taatjes; David Hemenway; Pamela M Vacek; Bruce Freeman; Stanley L Hazen; Marie Luise Brennan; Brooke T Mossman
Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice.
Cancer research 2005;65(21):9670-7.
2005: Dao-Quan Peng; Zhiping Wu; Gregory Brubaker; Lemin Zheng; Megan Settle; Eitan Gross; Michael Kinter; Stanley L Hazen; Jonathan D. Smith
Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities.
The Journal of biological chemistry 2005;280(40):33775-84.
2005: Gregory Kato ; Sabrina Martyr; William C Blackwelder; James S Nichols; Wynona A Coles; Lori A Hunter; Marie-Luise Brennan; Stanley L Hazen; Mark T Gladwin
Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality.
British journal of haematology 2005;130(6):943-53.
2005: Stephen J Nicholls; Lemin Zheng; Stanley L Hazen
Formation of dysfunctional high-density lipoprotein by myeloperoxidase.
Trends in cardiovascular medicine 2005;15(6):212-9.
2005: Suzy A A Comhair; Kristin S Ricci; Mercedes E Arroliga; Abigail R Lara; raed dweik; Wei Song; Stanley L Hazen; Eugene R Bleecker; William W Busse; K Fan Chung; Benjamin Gaston; Annette Hastie; Mark Hew; Nizar N Jarjour; Wendy Moore; Stephen Peters; W Gerald Teague; Sally E Wenzel; Serpil C Erzurum
Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma.
American journal of respiratory and critical care medicine 2005;172(3):306-13.
2005: Claudia R Morris; Gregory Kato ; Mirjana Poljakovic; Xunde Wang; William C Blackwelder; Vandana Sachdev; Stanley L Hazen; Elliott P Vichinsky; Sidney Morris; Mark T Gladwin
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
JAMA : the journal of the American Medical Association 2005;294(1):81-90.
2005: Elena A Komarova; Vadim I Krivokrysenko; Kaihua Wang; Nickolay Neznanov; Mikhail V Chernov; Pavel G Komarov; Marie-Luise Brennan; Tatyana V Golovkina; Oskar W Rokhlin; Dmitry V Kuprash; Sergei A Nedospasov; Stanley L Hazen; Elena Feinstein; Andrei V Gudkov
p53 is a suppressor of inflammatory response in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):1030-2.
2005: Stephen J Nicholls; Stanley L Hazen
Myeloperoxidase and cardiovascular disease.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(6):1102-11.
2005: Suzy A A Comhair; Weiling Xu; Sudakshina Ghosh; Frederik B J M Thunnissen; alex almasan; William J Calhoun; Allison J Janocha; Lemin Zheng; Stanley L Hazen; Serpil C Erzurum
Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity.
The American journal of pathology 2005;166(3):663-74.
2005: Peter B Anning; Barbara Coles; Alexandra Bermudez-Fajardo; Patricia E M Martin; Bruce S Levison; Stanley L Hazen; Colin D Funk; Hartmut Kühn; Valerie B O'Donnell
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
The American journal of pathology 2005;166(3):653-62.
2005: Lemin Zheng; Megan Settle; Gregory Brubaker; Dave Schmitt; Stanley L Hazen; Jonathan D. Smith; Michael Kinter
Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages.
The Journal of biological chemistry 2005;280(1):38-47.
2005: Stephen J Nicholls; Zhongzhou Shen; Xiaoming Fu; Bruce Levison; Stanley L Hazen
Quantification of 3-nitrotyrosine levels using a benchtop ion trap mass spectrometry method.
Methods in enzymology 2005;396():245-66.
2005: W H Wilson Tang; Kiran Philip; Stanley L Hazen; Cindy E Stevenson; Michael Pepoy; Sarah Neale; Gary S Francis; Frederick Van Lente; Andrew Smith; Alan H B Wu
Comparative sensitivities between different plasma B-type natriuretic peptide assays in patients with minimally symptomatic heart failure.
Clinical cornerstone 2005;7 Suppl 1():S18-24.
2004: Benedicta N Nukuna; Marc S Penn; Vernon E Anderson; Stanley L Hazen
Latency and substrate binding globally reduce solvent accessibility of plasminogen activator inhibitor type 1 (PAI-1). An adaptation of PAI-1 conformer crystal structures by hydrogen-deuterium exchange.
The Journal of biological chemistry 2004;279(48):50132-41.
2004: Weiling Xu; F Takao Kaneko; Shuo Zheng; Suzy A A Comhair; Allison J Janocha; Tannishia Goggans; Frederik B J M Thunnissen; Carol Farver; Stanley L Hazen; Constance Jennings; raed dweik; Alejandro C Arroliga; Serpil C Erzurum
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1746-8.
2004: Stephen J Nicholls; Stanley L Hazen
The role of myeloperoxidase in the pathogenesis of coronary artery disease.
Japanese journal of infectious diseases 2004;57(5):S21-2.
2004: David F Moore; Frank Ye; Marie-Luise Brennan; Surya Gupta; Bruce A Barshop; Robert D Steiner; William J Rhead; Roscoe O Brady; Stanley L Hazen; Raphael Schiffmann
Ascorbate decreases Fabry cerebral hyperperfusion suggesting a reactive oxygen species abnormality: an arterial spin tagging study.
Journal of magnetic resonance imaging : JMRI 2004;20(4):674-83.
2004: Carlos Milla; Shuxia Yang; David N Cornfield; Marie-Luise Brennan; Stanley L Hazen; Angela Panoskaltsis-Mortari; Bruce R Blazar; Imad Y Haddad
Myeloperoxidase deficiency enhances inflammation after allogeneic marrow transplantation.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L706-14.
2004: Husam M Abu-Soud; Frank M Raushel; Stanley L Hazen
A novel multistep mechanism for oxygen binding to ferrous hemoproteins: rapid kinetic analysis of ferrous-dioxy myeloperoxidase (compound III) formation.
Biochemistry 2004;43(36):11589-95.
2004: Joseph A Vita; Marie-Luise Brennan; Noyan Gokce; Shirley A Mann; Marlene Goormastic; Mehdi H Shishehbor; Marc S Penn; John F Keaney; Stanley L Hazen
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans.
Circulation 2004;110(9):1134-9.
2004: Zhiping Chen; John F Keaney; Eberhard Schulz; Bruce Levison; Lian Shan; Masashi Sakuma; Xiaobin Zhang; Can Shi; Stanley L Hazen; Daniel I Simon
Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13014-9.
2004: Lemin Zheng; Benedicta Nukuna; Marie-Luise Brennan; Mingjiang Sun; Marlene Goormastic; Megan Settle; Dave Schmitt; Xiaoming Fu; Leonor Thomson; Paul L Fox; Harry Ischiropoulos; Jonathan D. Smith; Michael Kinter; Stanley L Hazen
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.
The Journal of clinical investigation 2004;114(4):529-41.
2004: John L Petersen; Kenneth W Mahaffey; Richard C Becker; Shaun G Goodman; Neal S Kleiman; A J Marian; Gregg W Stone; Alexandra J Lansky; A Michael Lincoff; Stanley L Hazen; Christopher C. Nessel; Luis Toro-Figueroa; Lynn Tate; Craig J Reist; Marc Cohen; Robert M Califf; James J Ferguson
Coordinated series of studies to evaluate characteristics and mechanisms of acute coronary syndromes in high-risk patients randomly assigned to enoxaparin or unfractionated heparin: design and rationale of the SYNERGY Library.
American heart journal 2004;148(2):269-76.
2004: Stanley L Hazen
Myeloperoxidase and plaque vulnerability.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(7):1143-6.
2004: Thomas Koeck; Xiaoming Fu; Stanley L Hazen; John W Crabb; Dennis J Stuehr; kulwant aulak
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria.
The Journal of biological chemistry 2004;279(26):27257-62.
2004: Thomas Koeck; Bruce Levison; Stanley L Hazen; John W Crabb; Dennis J Stuehr; kulwant aulak
Tyrosine nitration impairs mammalian aldolase A activity.
Molecular & cellular proteomics : MCP 2004;3(6):548-57.
2004: Mehdi H Shishehbor; Stanley L Hazen
Inflammatory and oxidative markers in atherosclerosis: relationship to outcome.
Current atherosclerosis reports 2004;6(3):243-50.
2004: Mehdi H Shishehbor; Stanley L Hazen
Antioxidant studies need a change of direction.
Cleveland Clinic journal of medicine 2004;71(4):285-8.
2004: Caryn Vadseth; José M Souza; Leonor Thomson; Amy Seagraves; Chandrasekaran Nagaswami; Tomas Scheiner; Jim Torbet; Gaston Vilaire; Joel S Bennett; Juan-Carlos Murciano; Vladimir R Muzykantov; Marc S Penn; Stanley L Hazen; John W Weisel; Harry Ischiropoulos
Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species.
The Journal of biological chemistry 2004;279(10):8820-6.
2003: Arun K Thukkani; Jane McHowat; Fong-Fu Hsu; Marie-Luise Brennan; Stanley L Hazen; David A Ford
Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions.
Circulation 2003;108(25):3128-33.
2003: Marie-Luise Brennan; Stanley L Hazen
Amino acid and protein oxidation in cardiovascular disease.
Amino acids 2003;25(3-4):365-74.
2003: Eugenia Poliakov; Marie-Luise Brennan; Jennifer Macpherson; Renliang Zhang; Wei Sha; Laura Narine; Robert G Salomon; Stanley L Hazen
Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2209-20.
2003: Brian McElhinney; Matthew E Poynter; Punya Shrivastava; Stanley L Hazen; Yvonne M W Janssen-Heininger
Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner.
Journal of leukocyte biology 2003;74(5):897-907.
2003: Marie-Luise Brennan; Marc S Penn; Frederick Van Lente; Vijay Nambi; Mehdi H Shishehbor; Ronnier J Aviles; Marlene Goormastic; Michael L Pepoy; Ellen McErlean; Eric J Topol; Steven E Nissen; Stanley L Hazen
Prognostic value of myeloperoxidase in patients with chest pain.
The New England journal of medicine 2003;349(17):1595-604.
2003: Athena A Andreadis; Stanley L Hazen; Suzy A A Comhair; Serpil C Erzurum
Oxidative and nitrosative events in asthma.
Free radical biology & medicine 2003;35(3):213-25.
2003: Marie-Luise Brennan; Stanley L Hazen
Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment.
Current opinion in lipidology 2003;14(4):353-9.
2003: Mehdi H Shishehbor; Marie-Luise Brennan; Ronnier J Aviles; Xiaoming Fu; Marc S Penn; Dennis L Sprecher; Stanley L Hazen
Statins promote potent systemic antioxidant effects through specific inflammatory pathways.
Circulation 2003;108(4):426-31.
2003: Diana M Fries; Evgenia Paxinou; Marios Themistocleous; Eric Swanberg; Kathy K Griendling; Daniela Salvemini; Jan W Slot; Harry F G Heijnen; Stanley L Hazen; Harry Ischiropoulos
Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species.
The Journal of biological chemistry 2003;278(25):22901-7.
2003: Michael Samoszuk; Mark Corwin; Stanley L Hazen
Effects of human mast cell tryptase and eosinophil granule proteins on the kinetics of blood clotting.
American journal of hematology 2003;73(1):18-25.
2003: Mehdi H Shishehbor; Ronnier J Aviles; Marie-Luise Brennan; Xiaoming Fu; Marlene Goormastic; Gregory Pearce; Noyan Gokce; John F Keaney; Marc S Penn; Dennis L Sprecher; Joseph A Vita; Stanley L Hazen
Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy.
JAMA : the journal of the American Medical Association 2003;289(13):1675-80.
2003: Carolyn Albert; Arun K Thukkani; Rita M Heuertz; Arne Slungaard; Stanley L Hazen; David A Ford
Eosinophil peroxidase-derived reactive brominating species target the vinyl ether bond of plasmalogens generating a novel chemoattractant, alpha-bromo fatty aldehyde.
The Journal of biological chemistry 2003;278(11):8942-50.
2003: Arman T Askari; Marie-Luise Brennan; Xiaorong Zhou; Jeanne K Drinko; Annitta J Morehead; James David Thomas; Eric J Topol; Stanley L Hazen; Marc S Penn
Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction.
The Journal of experimental medicine 2003;197(5):615-24.
2003: Michael Samoszuk; Mark Corwin; Stanley L Hazen
Effects of human mast cell tryptase on the kinetics of blood clotting.
Thrombosis research 2003;109(2-3):153-6.
2002: Renliang Zhang; Marie-Luise Brennan; Zhongzhou Shen; Jennifer C MacPherson; Dave Schmitt; Cheryl E Molenda; Stanley L Hazen
Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation.
The Journal of biological chemistry 2002;277(48):46116-22.
2002: Eugene A Podrez; Eugenia Poliakov; Zhongzhou Shen; Renliang Zhang; Yijun Deng; Mingjiang Sun; Paula J Finton; Lian Shan; Maria Febbraio; David P Hajjar; Roy L Silverstein; Henry F Hoff; Robert G Salomon; Stanley L Hazen
A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.
The Journal of biological chemistry 2002;277(41):38517-23.
2002: Eugene A Podrez; Eugenia Poliakov; Zhongzhou Shen; Renliang Zhang; Yijun Deng; Mingjiang Sun; Paula J Finton; Lian Shan; Bogdan G Gugiu; Paul L Fox; Henry F Hoff; Robert G Salomon; Stanley L Hazen
Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36.
The Journal of biological chemistry 2002;277(41):38503-16.
2002: Stanley L Hazen; Guy M Chisolm
Oxidized phosphatidylcholines: pattern recognition ligands for multiple pathways of the innate immune response.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12515-7.
2002: Michael Samoszu; Marie-Luise Brennan; Vu To; Leonard Leonor; Lemin Zheng; Xiaoming Fu; Stanley L Hazen
Association between nitrotyrosine levels and microvascular density in human breast cancer.
Breast cancer research and treatment 2002;74(3):271-8.
2002: Marie-Luise Brennan; Weijia Wu; Xiaoming Fu; Zhongzhu Shen; Wei Song; Heather Frost; Caryn Vadseth; Laura Narine; Elizabeth Lenkiewicz; Michael T Borchers; Aldons J Lusis; James J Lee; Nancy A Lee; Husam M Abu-Soud; Harry Ischiropoulos; Stanley L Hazen
A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species.
The Journal of biological chemistry 2002;277(20):17415-27.
2002: Renliang Zhang; Zhongzhou Shen; William M Nauseef; Stanley L Hazen
Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma.
Blood 2002;99(5):1802-10.
2001: R Zhang; Marie-Luise Brennan; Xiaoming Fu; Ronnier J Aviles; Gregory Pearce; Marc S Penn; Eric J Topol; Dennis L Sprecher; Stanley L Hazen
Association between myeloperoxidase levels and risk of coronary artery disease.
JAMA : the journal of the American Medical Association 2001;286(17):2136-42.
2001: Husam M Abu-Soud; M Y Khassawneh; Ju-Tae Sohn; P Murray; M A Haxhiu; Stanley L Hazen
Peroxidases inhibit nitric oxide (NO) dependent bronchodilation: development of a model describing NO-peroxidase interactions.
Biochemistry 2001;40(39):11866-75.
2001: Husam M Abu-Soud; Stanley L Hazen
Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands.
Biochemistry 2001;40(36):10747-55.
2001: KL Denzler; Michael T Borchers; Jeffrey R Crosby; Grzegorz Cieslewicz; Edith M Hines; J Paul Justice; Stephania A Cormier; K A Lindenberger; W Song; W Wu; Stanley L Hazen; G J Gleich; James J Lee; Nancy A Lee
Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1672-82.
2001: J C MacPherson; Suzy A A Comhair; Serpil C Erzurum; donald klein; M F Lipscomb; mani kavuru; M K Samoszuk; Stanley L Hazen
Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5763-72.
2001: Z Shen; SN Mitra; Weijia Wu; Yishi Chen; Yanwu Yang; Jun Qin; Stanley L Hazen
Eosinophil peroxidase catalyzes bromination of free nucleosides and double-stranded DNA.
Biochemistry 2001;40(7):2041-51.
2001: Marie-Luise Brennan; Martin M Anderson; D M Shih; XD Qu; Xuping Wang; A C Mehta; L L Lim; W Shi; Stanley L Hazen; J S Jacob; Jan R Crowley; Jay W Heinecke; Aldons J Lusis
Increased atherosclerosis in myeloperoxidase-deficient mice.
The Journal of clinical investigation 2001;107(4):419-30.
2001: M Arlandson; T Decker; VA Roongta; L Bonilla; Kevin H Mayo; J C MacPherson; Stanley L Hazen; Arne Slungaard
Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system.
The Journal of biological chemistry 2001;276(1):215-24.
2000: Stanley L Hazen; Joseph P Gaut; JR Crowley; Fong-Fu Hsu; Jay W Heinecke
Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions.
The Biochemical journal 2000;352 Pt 3():693-9.
2000: Husam M Abu-Soud; Stanley L Hazen
Nitric oxide is a physiological substrate for mammalian peroxidases.
The Journal of biological chemistry 2000;275(48):37524-32.
2000: Eugene A Podrez; Husam M Abu-Soud; Stanley L Hazen
Myeloperoxidase-generated oxidants and atherosclerosis.
Free radical biology & medicine 2000;28(12):1717-25.
2000: Robert G Salomon; Eugenia Batyreva; K Kaur; D L Sprecher; Martin J Schreiber; J W Crabb; M S Penn; A M DiCorletoe; Stanley L Hazen; Eugene A Podrez
Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway.
Biochimica et biophysica acta 2000;1485(2-3):225-35.
2000: Z Shen; Weijia Wu; Stanley L Hazen
Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical.
Biochemistry 2000;39(18):5474-82.
2000: Weijia Wu; M K Samoszuk; Suzy A A Comhair; Mary Jane Thomassen; Carol Farver; raed dweik; mani kavuru; Serpil C Erzurum; Stanley L Hazen
Eosinophils generate brominating oxidants in allergen-induced asthma.
The Journal of clinical investigation 2000;105(10):1455-63.
2000: J I Heller; JR Crowley; Stanley L Hazen; D M Salvay; P Wagner; Subramaniam Pennathur; Jay W Heinecke
p-hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima.
The Journal of biological chemistry 2000;275(14):9957-62.
2000: Eugene A Podrez; Maria Febbraio; Nader Sheibani; Dave Schmitt; Roy L Silverstein; David P Hajjar; P A Cohen; William A Frazier; Henry F Hoff; Stanley L Hazen
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species.
The Journal of clinical investigation 2000;105(8):1095-108.
2000: Maria Febbraio; Eugene A Podrez; Jonathan D. Smith; David P Hajjar; Stanley L Hazen; Henry F Hoff; K Sharma; Roy L Silverstein
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.
The Journal of clinical investigation 2000;105(8):1049-56.
2000: Husam M Abu-Soud; Stanley L Hazen
Nitric oxide modulates the catalytic activity of myeloperoxidase.
The Journal of biological chemistry 2000;275(8):5425-30.
2000: SN Mitra; A Slungaard; Stanley L Hazen
Role of eosinophil peroxidase in the origins of protein oxidation in asthma.
Redox report : communications in free radical research 2000;5(4):215-24.
1999: D Schmitt; Z Shen; R Zhang; Scott M Colles; Weijia Wu; Robert G Salomon; Yishi Chen; Guy M Chisolm; Stanley L Hazen
Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum.
Biochemistry 1999;38(51):16904-15.
1999: Stanley L Hazen; R Zhang; Z Shen; Weijia Wu; Eugene A Podrez; J C MacPherson; Dave Schmitt; SN Mitra; C Mukhopadhyay; Yishi Chen; P A Cohen; Henry F Hoff; Husam M Abu-Soud
Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo.
Circulation research 1999;85(10):950-8.
1999: Guy M Chisolm; Stanley L Hazen; Paul L Fox; Martha K Cathcart
The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms.
The Journal of biological chemistry 1999;274(37):25959-62.
1999: Weijia Wu; Yishi Chen; Stanley L Hazen
Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders.
The Journal of biological chemistry 1999;274(36):25933-44.
1999: Eugene A Podrez; Dave Schmitt; Henry F Hoff; Stanley L Hazen
Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro.
The Journal of clinical investigation 1999;103(11):1547-60.
1999: Weijia Wu; Yishi Chen; A d'Avignon; Stanley L Hazen
3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo.
Biochemistry 1999;38(12):3538-48.
1999: Jay W Heinecke; Fong-Fu Hsu; JR Crowley; Stanley L Hazen; C Leeuwenburgh; Dianne M Mueller; J E Rasmussen; J Turk
Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues.
Methods in enzymology 1999;300():124-44.
1999: Stanley L Hazen; Fong-Fu Hsu; Joseph P Gaut; JR Crowley; Jay W Heinecke
Modification of proteins and lipids by myeloperoxidase.
Methods in enzymology 1999;300():88-105.
1999: Stanley L Hazen; J Heller; Fong-Fu Hsu; A d'Avignon; Jay W Heinecke
Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenylacetaldehyde with the amino headgroup of phosphatidylethanolamine and phosphatidylserine.
Chemical research in toxicology 1999;12(1):19-27.
1998: Stanley L Hazen; Fong-Fu Hsu; A d'Avignon; Jay W Heinecke
Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation.
Biochemistry 1998;37(19):6864-73.
1998: Stanley L Hazen; A d'Avignon; M M Anderson; Fong-Fu Hsu; Jay W Heinecke
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of reactive aldehydes. Mechanistic studies identifying labile intermediates along the reaction pathway.
The Journal of biological chemistry 1998;273(9):4997-5005.
1997: Stanley L Hazen; Joseph P Gaut; Fong-Fu Hsu; JR Crowley; A d'Avignon; Jay W Heinecke
p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues.
The Journal of biological chemistry 1997;272(27):16990-8.
1997: Stanley L Hazen; Jay W Heinecke
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
The Journal of clinical investigation 1997;99(9):2075-81.
1997: M M Anderson; Stanley L Hazen; Fong-Fu Hsu; Jay W Heinecke
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.
The Journal of clinical investigation 1997;99(3):424-32.
1997: C Leeuwenburgh; M M Hardy; Stanley L Hazen; P Wagner; S Oh-ishi; U P Steinbrecher; Jay W Heinecke
Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima.
The Journal of biological chemistry 1997;272(3):1433-6.
1997: Stanley L Hazen; JR Crowley; Dianne M Mueller; Jay W Heinecke
Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation.
Free radical biology & medicine 1997;23(6):909-16.
1996: Stanley L Hazen; F F Hsu; K Duffin; Jay W Heinecke
Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols.
The Journal of biological chemistry 1996;271(38):23080-8.
1996: Stanley L Hazen; F F Hsu; Dianne M Mueller; JR Crowley; Jay W Heinecke
Human neutrophils employ chlorine gas as an oxidant during phagocytosis.
The Journal of clinical investigation 1996;98(6):1283-9.
1996: J S Jacob; David Cistola; F F Hsu; S Muzaffar; Dianne M Mueller; Stanley L Hazen; Jay W Heinecke
Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway.
The Journal of biological chemistry 1996;271(33):19950-6.
1996: Stanley L Hazen; F F Hsu; Jay W Heinecke
p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes. A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase.
The Journal of biological chemistry 1996;271(4):1861-7.
1993: Stanley L Hazen; Richard W Gross
The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis.
The Journal of biological chemistry 1993;268(13):9892-900.