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Tapas Hazra

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Attila Bacsi; LEOPOLDO AGUILERA-AGUIRRE; Xueqing Ba; Tapas K Hazra; Zsolt Radák; Sanjiv Sur; Bartosz Szczesny; Istvan Boldogh
Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation.
Muralidhar Hegde; Pavana Hegde; Srijita Banerjee; Larry J Bellot; Istvan Boldogh; Tapas K Hazra; Sankar Mitra
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction.
Istvan Boldogh; Gyorgy Hajas; Tapas K Hazra; Muralidhar L Hegde; LEOPOLDO AGUILERA-AGUIRRE; Attila Bacsi; Zsolt Radák; Sanjiv Sur; Sankar Mitra
Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine.

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All Publications

2013: Attila Bacsi; LEOPOLDO AGUILERA-AGUIRRE; Xueqing Ba; Tapas K Hazra; Zsolt Radák; Sanjiv Sur; Bartosz Szczesny; Istvan Boldogh
Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation.
DNA repair 2013;12(1):18-26.
2012: Muralidhar Hegde; Pavana Hegde; Srijita Banerjee; Larry J Bellot; Istvan Boldogh; Tapas K Hazra; Sankar Mitra
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction.
The Journal of biological chemistry 2012;287(41):34202-11.
2012: Istvan Boldogh; Gyorgy Hajas; Tapas K Hazra; Muralidhar L Hegde; LEOPOLDO AGUILERA-AGUIRRE; Attila Bacsi; Zsolt Radák; Sanjiv Sur; Sankar Mitra
Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine.
The Journal of biological chemistry 2012;287(25):20769-73.
2012: Sanjib Dey; Bo Hang; Sherif Z Abdel-Rahman; Istvan Boldogh; Victor Cardenas; Muralidhar Hegde; Pavana Hegde; Dongxin Lin; Amit K Maiti; Partha S Sarkar; Altaf H Sarker; Binghui Shen; Alan E Tomkinson; Guanghai Wang; Chen Wu; Jingwu Xie; Dianke Yu; Mian Zhou; Tapas K Hazra
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
DNA repair 2012;11(6):570-8.
2012: Muralidhar Hegde; Anil K Mantha; Sankar Mitra; Kishor K Bhakat; Tapas K Hazra; Bartosz Szczesny
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.
Mechanisms of ageing and development 2012;133(4):157-68.
2012: Gyorgy Hajas; Tapas K Hazra; Zsolt Radák; Sanjiv Sur; Leopoldo Aguilerra-Aguirre; Attila Bacsi; Peter German; Istvan Boldogh
Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base.
Free radical biology & medicine 2012;52(4):749-56.
2012: Mandal Santi; Partha S Sarkar; Bartosz Szczesny; Muralidhar Hegde; Pavana Hegde; Dibyendu Banerjee; Istvan Boldogh; Arpita Chatterjee; Maria Falkenberg; Rui Gao; Claes M Gustafsson; Tapas K Hazra
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.
The Journal of biological chemistry 2012;287(4):2819-29.
2010: Muralidhar Hegde; Tapas K Hazra; Sankar Mitra
Functions of disordered regions in mammalian early base excision repair proteins.
Cellular and molecular life sciences : CMLS 2010;67(21):3573-87.
2010: Corey A Theriot; Muralidhar Hegde; Tapas K Hazra; Sankar Mitra
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures.
DNA repair 2010;9(6):643-52.
2009: Grzegorz Chodaczek; Attila Bacsi; Nilesh Dharajiya; Sanjiv Sur; Tapas K Hazra; Istvan Boldogh
Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction.
Molecular immunology 2009;46(13):2505-14.
2008: Ranajoy Chattopadhyay; Soumita Das; Amit K Maiti; Istvan Boldogh; Jingwu Xie; Tapas K Hazra; Kimitoshi Kohno; Sankar Mitra; Kishor K Bhakat
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.
Molecular and cellular biology 2008;28(23):7066-80.
2008: Muralidhar Hegde; Corey A Theriot; Aditi Das; Pavana Hegde; Zhigang Guo; Ronald K Gary; Tapas K Hazra; Binghui Shen; Sankar Mitra
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.
The Journal of biological chemistry 2008;283(40):27028-37.
2008: Amit K Maiti; Istvan Boldogh; Heidi Spratt; Sankar Mitra; Tapas K Hazra
Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme.
DNA repair 2008;7(8):1213-20.
2008: Varatharasa Thiviyanathan; Anoma Somasunderam; David Volk; Tapas K Hazra; Sankar Mitra; David Gorenstein
Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil.
Biochemical and biophysical research communications 2008;366(3):752-7.
2008: Hong Dou; Corey A Theriot; Aditi Das; Muralidhar Hegde; Yoshihiro Matsumoto; Istvan Boldogh; Tapas K Hazra; Kishor K Bhakat; Sankar Mitra
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.
The Journal of biological chemistry 2008;283(6):3130-40.
2008: Muralidhar Hegde; Tapas K Hazra; Sankar Mitra
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.
Cell research 2008;18(1):27-47.
2007: Attila Bacsi; Grzegorz Chodaczek; Tapas K Hazra; David Konkel; Istvan Boldogh
Increased ROS generation in subsets of OGG1 knockout fibroblast cells.
Mechanisms of ageing and development 2007;128(11-12):637-49.
2007: Soumita Das; Ranajoy Chattopadhyay; Kishor K Bhakat; Istvan Boldogh; Kimitoshi Kohno; Rajendra Prasad; Samuel H Wilson; Tapas K Hazra
Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress.
The Journal of biological chemistry 2007;282(39):28474-84.
2007: Aditi Das; Istvan Boldogh; Jae Wan Lee; Jeanine A Harrigan; Muralidhar Hegde; Jason Piotrowski; Nadja C de Souza-Pinto; William Ramos; Marc M Greenberg; Tapas K Hazra; Sankar Mitra; Vilhelm A Bohr
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1.
The Journal of biological chemistry 2007;282(36):26591-602.
2007: Tapas K Hazra; Aditi Das; Soumita Das; Sujata Choudhury; Yoke W Kow; Rabindra Roy
Oxidative DNA damage repair in mammalian cells: a new perspective.
DNA repair 2007;6(4):470-80.
2007: Xin Guan; Haibo Bai; Guoli Shi; Corey A Theriot; Tapas K Hazra; Sankar Mitra; A-Lien Lu-Chang
The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase.
Nucleic acids research 2007;35(8):2463-72.
2006: Aditi Das; Lee Wiederhold; John B Leppard; Padmini Kedar; Rajendra Prasad; Huxian Wang; Istvan Boldogh; Feridoun Karimi-Busheri; Michael Weinfeld; Alan E Tomkinson; Samuel H Wilson; Sankar Mitra; Tapas K Hazra
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells.
DNA repair 2006;5(12):1439-48.
2006: Gokul C Das; Attila Bacsi; Meena Shrivastav; Tapas K Hazra; Istvan Boldogh
Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity.
Molecular carcinogenesis 2006;45(9):635-47.
2006: Kishor K Bhakat; Sanath K Mokkapati; Istvan Boldogh; Tapas K Hazra; Sankar Mitra
Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo.
Molecular and cellular biology 2006;26(5):1654-65.
2006: Tapas K Hazra; Sankar Mitra
Purification and characterization of NEIL1 and NEIL2, members of a distinct family of mammalian DNA glycosylases for repair of oxidized bases.
Methods in enzymology 2006;408():33-48.
2006: Ranajoy Chattopadhyay; Lee Wiederhold; Bartosz Szczesny; Istvan Boldogh; Tapas K Hazra; Tadahide Izumi; Sankar Mitra
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.
Nucleic acids research 2006;34(7):2067-76.
2005: Attila Bacsi; Subbaraj Kannan; Myung Soog Lee; Tapas K Hazra; Istvan Boldogh
Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells.
Free radical biology & medicine 2005;39(12):1650-9.
2005: Aditi Das; Tapas K Hazra; Istvan Boldogh; Sankar Mitra; Kishor K Bhakat
Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species.
The Journal of biological chemistry 2005;280(42):35272-80.
2005: Istvan Boldogh; Attila Bacsi; Barun K Choudhury; Nilesh Dharajiya; Rafeul Alam; Tapas K Hazra; Sankar Mitra; Randall M Goldblum; Sanjiv Sur
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation.
The Journal of clinical investigation 2005;115(8):2169-79.
2005: Mohsin M Ali; Tapas K Hazra; Dou Hong; Yoke W Kow
Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil.
DNA repair 2005;4(6):679-86.
2004: Aditi Das; Lavanya Rajagopalan; Venkatarajan S Mathura; Samuel J Rigby; Sankar Mitra; Tapas K Hazra
Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein.
The Journal of biological chemistry 2004;279(45):47132-8.
2004: Sanath K Mokkapati; Lee Wiederhold; Tapas K Hazra; Sankar Mitra
Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases.
Biochemistry 2004;43(36):11596-604.
2004: Lee Wiederhold; John B Leppard; Padmini Kedar; Feridoun Karimi-Busheri; Aghdass Rasouli-Nia; Michael Weinfeld; Alan E Tomkinson; Tadahide Izumi; Rajendra Prasad; Samuel H Wilson; Sankar Mitra; Tapas K Hazra
AP endonuclease-independent DNA base excision repair in human cells.
Molecular cell 2004;15(2):209-20.
2004: Kishor K Bhakat; Tapas K Hazra; Sankar Mitra
Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.
Nucleic acids research 2004;32(10):3033-9.
2003: Hong Dou; Sankar Mitra; Tapas K Hazra
Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.
The Journal of biological chemistry 2003;278(50):49679-84.
2003: Kishor K Bhakat; Tadahide Izumi; Suk-Hoon Yang; Tapas K Hazra; Sankar Mitra
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
The EMBO journal 2003;22(23):6299-309.
2003: Istvan Boldogh; Gargi Roy; Myung Soog Lee; Attila Bacsi; Tapas K Hazra; Kishor K Bhakat; Gokul C Das; Sankar Mitra
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.
Toxicology 2003;193(1-2):137-52.
2003: Tadahide Izumi; Lee Wiederhold; Gargi Roy; Rabindra Roy; Arun Jaiswal; Kishor K Bhakat; Sankar Mitra; Tapas K Hazra
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage.
Toxicology 2003;193(1-2):43-65.
2003: Bartosz Szczesny; Tapas K Hazra; John Papaconstantinou; Sankar Mitra; Istvan Boldogh
Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10670-5.
2003: Tapas K Hazra; Tadahide Izumi; Yoke W Kow; Sankar Mitra
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications.
Carcinogenesis 2003;24(2):155-7.
2003: Varatharasa Thiviyanathan; Anoma Somasunderam; Tapas K Hazra; Sankar Mitra; David Gorenstein
Solution structure of a DNA duplex containing 8-hydroxy-2'-deoxyguanosine opposite deoxyguanosine.
Journal of molecular biology 2003;325(3):433-42.
2002: Tapas K Hazra; Yoke W Kow; Zafer Hatahet; Barry Imhoff; Istvan Boldogh; Sanath K Mokkapati; Sankar Mitra; Tadahide Izumi
Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.
The Journal of biological chemistry 2002;277(34):30417-20.
2002: Sankar Mitra; Tadahide Izumi; Istvan Boldogh; Kishor K Bhakat; Jeff W Hill; Tapas K Hazra
Choreography of oxidative damage repair in mammalian genomes.
Free radical biology & medicine 2002;33(1):15-28.
2002: Tapas K Hazra; Tadahide Izumi; Istvan Boldogh; Barry Imhoff; Yoke W Kow; Pawel Jaruga; Miral Dizdaroglu; Sankar Mitra
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3523-8.
2001: Miral Dizdaroglu; S M Burgess; Pawel Jaruga; Tapas K Hazra; Henry Rodriguez; R Stephen Lloyd
Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals.
Biochemistry 2001;40(40):12150-6.
2001: Tapas K Hazra; James G Muller; Raymond C Manuel; Cynthia J Burrows; R Stephen Lloyd; Sankar Mitra
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli.
Nucleic acids research 2001;29(9):1967-74.
2001: Enrico Cappelli; Tapas K Hazra; J W Hill; G Slupphaug; Massimo Bogliolo; Guido Frosina
Rates of base excision repair are not solely dependent on levels of initiating enzymes.
Carcinogenesis 2001;22(3):387-93.
2001: Jeff W Hill; Tapas K Hazra; Tadahide Izumi; Sankar Mitra
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.
Nucleic acids research 2001;29(2):430-8.
2001: S Mitra; I Boldogh; T Izumi; Tapas K Hazra
Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage.
Environmental and molecular mutagenesis 2001;38(2-3):180-90.
2001: Tapas K Hazra; Jeff W Hill; Tadahide Izumi; Sankar Mitra
Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.
Progress in nucleic acid research and molecular biology 2001;68():193-205.
2000: Tapas K Hazra; Tadahide Izumi; R Venkataraman; Yoke W Kow; Miral Dizdaroglu; Sankar Mitra
Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII.
The Journal of biological chemistry 2000;275(36):27762-7.
2000: Tadahide Izumi; Tapas K Hazra; Istvan Boldogh; Alan E Tomkinson; M S Park; S Ikeda; Sankar Mitra
Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species.
Carcinogenesis 2000;21(7):1329-34.
2000: G Wang; Tapas K Hazra; Sankar Mitra; Heung-Man Lee; Ella W Englander
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Nucleic acids research 2000;28(10):2135-40.
1999: Tapan Biswas; chilakamarti ramana; G Srinivasan; Istvan Boldogh; Tapas K Hazra; Z Chen; K Tano; E Brad Thompson; Sankar Mitra
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone.
Oncogene 1999;18(2):525-32.
1998: Tapas K Hazra; Tadahide Izumi; L Maidt; R A Floyd; Sankar Mitra
The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.
Nucleic acids research 1998;26(22):5116-22.
1998: Istvan Boldogh; chilakamarti ramana; Z Chen; Tapan Biswas; Tapas K Hazra; S Grösch; T Grombacher; Sankar Mitra; B Kaina
Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling.
Cancer research 1998;58(17):3950-6.
1998: Rabindra Roy; Tapan Biswas; Tapas K Hazra; G Roy; D T Grabowski; Tadahide Izumi; G Srinivasan; Sankar Mitra
Specific interaction of wild-type and truncated mouse N-methylpurine-DNA glycosylase with ethenoadenine-containing DNA.
Biochemistry 1998;37(2):580-9.
1997: Sankar Mitra; Tapas K Hazra; Rabindra Roy; S Ikeda; Tapan Biswas; J Lock; Istvan Boldogh; Tadahide Izumi
Complexities of DNA base excision repair in mammalian cells.
Molecules and cells 1997;7(3):305-12.
1997: Tapas K Hazra; Rabindra Roy; Tapan Biswas; D T Grabowski; A E Pegg; Sankar Mitra
Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.
Biochemistry 1997;36(19):5769-76.